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223 results on '"Re, T."'

1. An Automated Brain Metastasis Detection and Segmentation System from MRI with a Large Multi-Institutional Dataset

Author

Yoo, Y., primary, Gibson, E., additional, Zhao, G., additional, Sandu, A., additional, Re, T., additional, Das, J., additional, Hesheng, W., additional, Kim, M.M., additional, Shen, C., additional, Lee, Y.Z., additional, Kondziolka, D., additional, Ibrahim, M., additional, Lian, J., additional, Jain, R., additional, Zhu, T., additional, Parmar, H., additional, Comaniciu, D., additional, Balter, J., additional, and Cao, Y., additional

Published
2023
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2. Dysmetabolism, Diabetes and Clinical Outcomes in Patients Cured of Chronic Hepatitis C: A Real-Life Cohort Study

Author

Valenti, L, Pelusi, S, Aghemo, A, Gritti, S, Pasulo, L, Bianco, C, Iegri, C, Cologni, G, Degasperi, E, D'Ambrosio, R, del Poggio, P, Soria, A, Puoti, M, Carderi, I, Pigozzi, M, Carriero, C, Spinetti, A, Zuccaro, V, Memoli, M, Giorgini, A, Vigano, M, Rumi, M, Re, T, Spinelli, O, Colombo, M, Quirino, T, Menzaghi, B, Lorini, G, Pan, A, D'Arminio Monforte, A, Buscarini, E, Autolitano, A, Bonfanti, P, Terreni, N, Aimo, G, Mendeni, M, Prati, D, Lampertico, P, Fagiuoli, S, Valenti L., Pelusi S., Aghemo A., Gritti S., Pasulo L., Bianco C., Iegri C., Cologni G., Degasperi E., D'Ambrosio R., del Poggio P., Soria A., Puoti M., Carderi I., Pigozzi M. G., Carriero C., Spinetti A., Zuccaro V., Memoli M., Giorgini A., Vigano M., Rumi M. G., Re T., Spinelli O., Colombo M. C., Quirino T., Menzaghi B., Lorini G., Pan A., D'Arminio Monforte A., Buscarini E., Autolitano A., Bonfanti P., Terreni N., Aimo G., Mendeni M., Prati D., Lampertico P., Colombo M., Fagiuoli S., Valenti, L, Pelusi, S, Aghemo, A, Gritti, S, Pasulo, L, Bianco, C, Iegri, C, Cologni, G, Degasperi, E, D'Ambrosio, R, del Poggio, P, Soria, A, Puoti, M, Carderi, I, Pigozzi, M, Carriero, C, Spinetti, A, Zuccaro, V, Memoli, M, Giorgini, A, Vigano, M, Rumi, M, Re, T, Spinelli, O, Colombo, M, Quirino, T, Menzaghi, B, Lorini, G, Pan, A, D'Arminio Monforte, A, Buscarini, E, Autolitano, A, Bonfanti, P, Terreni, N, Aimo, G, Mendeni, M, Prati, D, Lampertico, P, Fagiuoli, S, Valenti L., Pelusi S., Aghemo A., Gritti S., Pasulo L., Bianco C., Iegri C., Cologni G., Degasperi E., D'Ambrosio R., del Poggio P., Soria A., Puoti M., Carderi I., Pigozzi M. G., Carriero C., Spinetti A., Zuccaro V., Memoli M., Giorgini A., Vigano M., Rumi M. G., Re T., Spinelli O., Colombo M. C., Quirino T., Menzaghi B., Lorini G., Pan A., D'Arminio Monforte A., Buscarini E., Autolitano A., Bonfanti P., Terreni N., Aimo G., Mendeni M., Prati D., Lampertico P., Colombo M., and Fagiuoli S.

Abstract

The aim of this study was to examine the impact of features of dysmetabolism on liver disease severity, evolution, and clinical outcomes in a real-life cohort of patients treated with direct acting antivirals for chronic hepatitis C virus (HCV) infection. To this end, we considered 7,007 patients treated between 2014 and 2018, 65.3% with advanced fibrosis, of whom 97.7% achieved viral eradication (NAVIGATORE-Lombardia registry). In a subset (n = 748), liver stiffness measurement (LSM) was available at baseline and follow-up. Higher body mass index (BMI; odds ratio [OR] 1.06 per kg/m2, 1.03-1.09) and diabetes (OR 2.01 [1.65-2.46]) were independently associated with advanced fibrosis at baseline, whereas statin use was protective (OR 0.46 [0.35-0.60]; P < 0.0001 for all). The impact of BMI was greater in those without diabetes (P = 0.003). Diabetes was independently associated with less pronounced LSM improvement after viral eradication (P = 0.001) and in patients with advanced fibrosis was an independent predictor of the most frequent clinical events, namely de novo hepatocellular carcinoma (HCC; hazard ratio [HR] 2.09 [1.20-3.63]; P = 0.009) and cardiovascular events (HR 2.73 [1.16-6.43]; P = 0.021). Metformin showed a protective association against HCC (HR 0.32 [0.11-0.96]; P = 0.043), which was confirmed after adjustment for propensity score (P = 0.038). Diabetes diagnosis further refined HCC prediction in patients with compensated advanced chronic liver disease at high baseline risk (P = 0.024). Conclusion: Metabolic comorbidities were associated with advanced liver fibrosis at baseline, whereas statins were protective. In patients with advanced fibrosis, diabetes increased the risk of de novo HCC and of cardiovascular events. Optimization of metabolic comorbidities treatment by a multi-disciplinary management approach may improve cardiovascular and possibly liver-related

Published
2022

4. Pegylated interferon α plus ribavirin for the treatment of chronic hepatitis C: A multicentre independent study supported by the Italian Drug Agency

Author

Mascolo, M.C., Cursaro, C., Scuteri, A., Ranieri, J., Monti, M., Bellentani, S., Gasbarrini, A., Pompili, M., Puoti, C., Bellis, L., Regazzetti, A., Maffezzini, E., Pietrangelo, A., Abbati, G., Raimondo, G., Scribano, L., Martines, D., Baroni, G. Svegliati, Faraci, G., Schianchi, S., Fornaciari, G., Fabris, P., Madonia, S., Civitavecchia, G., Pirisi, M., Smirne, C., Borghi, A., Sardini, C., Andreoletti, M., Morisco, F., Caporaso, N., Fargion, S., Fatta, E., Masutti, F., Bonaventura, M.E., Autolitano, A., Russello, M., Bellia, A., Toniutto, P., Bitetto, D., Mecenate, F., Pasulo, L., Lucà, M.G., Picardi, A., Vespasiani, U., Grattagliano, I., Palasciano, G., Romagno, D., Crespi, C., Gianstefani, A., Gobbo, G., Monti, V., Giannelli, G., Napoli, N., Nosotti, Raspanti, A., Cuccorese, Colombo, A.E., Floridia, Plattella, M.S., Cassano, P., Gentile, I., Blanc, P.L., Messina, V., Bonfante, S., Bellissima, P., Toti, M., Vecchiet, J., Falasca, K., Portelli, V., De Stefano, G., Pietromatera, G., Viganò, P., Re, T., Andreoni, M., Raineri, G., Massari, M., Grossi, P.A., Caputo, S., Cassola, G., Feasi, M., Foti, G., Kunkar, A., Corti, G., Baragli, F., Caterini, L., Migliorini, D., Chiodera, A., Calleri, G., Spezia, C., Baiguera, C., Puoti, M., Brancaccio, G., Gaeta, G.B., Vento, S., Di Biagio, A., Nicolini, L., Liberti, A., Iannece, M.D., Contini, C., Tacconi, D., Caremani, M., Almi, P., Chimenti, M., Cosco, Messeri, D., Esperti, F.C., Paffetti, A., Mastropietro, C., Moretti, A., Spagnolo, A.L., Lomonaco, L., Calì, A., Mandelli, G., Spinzi, G.C., Framarin, L., Berrutti, M., Boccia, S., Simone, L., Pazzi, P., Fornari, F., Comparato, G., Casetti, T., Foschi, F.G., Bertin, T., Salvagnini, M., Samori, A., Ferretti, E., Casiraghi, M.A., Marin, R., Ciancio, A., Campo, N., Testa, R., Rocco, A., Federico, A., Loguercio, C., Rizzo, S., Giannini, E.G., Corbo, M., Riegler, G., Esposito, P., Ricci, G.L., Rosina, Floriano, Tosti, Maria Elena, Borghesio, Elisabetta, Masocco, Maria, Mele, Alfonso, Coppola, Carmine, Milella, Michele, Borgia, Guglielmo, Andreone, Pietro, Koch, Maurizio, Zignego, Anna Linda, Romano, Mario, Carrara, Maurizio, Almasio, Piero Luigi, Azzola, Emilio, Nardone, Gerardo, Benedetti, Antonio, Carosi, Giampiero, Mazzotta, Francesco, Sagnelli, Evangelista, and Rizzetto, Mario

Published
2014
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5. High rates of sustained virological response despite premature discontinuation of directly acting antivirals in HCV-infected patients treated in a real-life setting

Author

Fabbiani, M, Lombardi, A, Colaneri, M, Del Poggio, P, Perini, P, D'Ambrosio, R, Degasperi, E, Dibenedetto, C, Giorgini, A, Pasulo, L, Maggiolo, F, Castelli, F, Brambilla, P, Spinelli, O, Re, T, Lleo, A, Rumi, M, Uberti-Foppa, C, Soria, A, Aghemo, A, Lampertico, P, Baiguera, C, Schiavini, M, Fagiuoli, S, Bruno, R, Borghi, M, Soffredini, R, Perbellini, R, Gori, A, Ferroni, V, Colpani, M, Manini, M, Cologni, G, Lazzaroni, S, Vinci, M, De Nicola, S, Mazzarelli, C, Angelini Zucchetti, T, Picciotto, V, Puoti, M, Rossotti, R, Landonio, S, Magni, C, Rizzardini, G, Colella, E, Columpsi, P, Gambaro, A, Spolti, A, Magnani, C, Vigano, P, Mena, M, Villa, M, Caramma, I, Basilico, C, Capelli, F, Biagiotti, S, Mazzone, A, Saladino, V, Baldacci, M, Gatti, F, Varalli, L, Morini, L, Menzaghi, B, Farinazzo, M, Meli, R, Plaz Torres, M, Fanetti, I, Orellana, D, Zermiani, P, Zuin, M, De Bona, A, D'Arminio Monforte, A, Capretti, A, Taddei, M, Soncini, M, Spinetti, A, Zaltron, S, Pigozzi, M, Rossini, A, Pan, A, Dal Zoppo, S, Zoncada, A, Memoli, M, Salpietro, S, Hamid, H, Messina, E, Colombo, A, Giglio, O, Bonfanti, P, Molteni, C, Terreni, N, Spinzi, G, Conforti, S, Clerici, E, Menozzi, F, Buscarini, E, Centenaro, R, Corbellini, A, Noventa, F, Gritti, S, Giani, P, Fabbiani M., Lombardi A., Colaneri M., Del Poggio P., Perini P., D'Ambrosio R., Degasperi E., Dibenedetto C., Giorgini A., Pasulo L., Maggiolo F., Castelli F., Brambilla P., Spinelli O., Re T., Lleo A., Rumi M., Uberti-Foppa C., Soria A., Aghemo A., Lampertico P., Baiguera C., Schiavini M., Fagiuoli S., Bruno R., Borghi M., Soffredini R., Perbellini R., Gori A., Ferroni V., Colpani M., Manini M., Cologni G., Lazzaroni S., Vinci M., De Nicola S., Mazzarelli C., Angelini Zucchetti T., Picciotto V., Puoti M., Rossotti R., Landonio S., Magni C. F., Rizzardini G., Colella E., Columpsi P., Gambaro A., Spolti A., Magnani C., Vigano P., Mena M., Villa M., Caramma I., Basilico C., Capelli F., Biagiotti S., Mazzone A., Saladino V., Baldacci M. P., Gatti F., Varalli L., Morini L., Menzaghi B., Farinazzo M., Meli R., Plaz Torres M. C., Fanetti I., Orellana D., Zermiani P., Zuin M., De Bona A., D'Arminio Monforte A., Capretti A., Taddei M. T., Soncini M., Spinetti A., Zaltron S., Pigozzi M. G., Rossini A., Pan A., Dal Zoppo S., Zoncada A., Memoli M., Salpietro S., Hamid H., Messina E., Colombo A. E., Giglio O., Bonfanti P., Molteni C., Terreni N., Spinzi G., Conforti S., Clerici E., Menozzi F., Buscarini E., Centenaro R., Corbellini A., Noventa F., Gritti S., Giani P., Fabbiani, M, Lombardi, A, Colaneri, M, Del Poggio, P, Perini, P, D'Ambrosio, R, Degasperi, E, Dibenedetto, C, Giorgini, A, Pasulo, L, Maggiolo, F, Castelli, F, Brambilla, P, Spinelli, O, Re, T, Lleo, A, Rumi, M, Uberti-Foppa, C, Soria, A, Aghemo, A, Lampertico, P, Baiguera, C, Schiavini, M, Fagiuoli, S, Bruno, R, Borghi, M, Soffredini, R, Perbellini, R, Gori, A, Ferroni, V, Colpani, M, Manini, M, Cologni, G, Lazzaroni, S, Vinci, M, De Nicola, S, Mazzarelli, C, Angelini Zucchetti, T, Picciotto, V, Puoti, M, Rossotti, R, Landonio, S, Magni, C, Rizzardini, G, Colella, E, Columpsi, P, Gambaro, A, Spolti, A, Magnani, C, Vigano, P, Mena, M, Villa, M, Caramma, I, Basilico, C, Capelli, F, Biagiotti, S, Mazzone, A, Saladino, V, Baldacci, M, Gatti, F, Varalli, L, Morini, L, Menzaghi, B, Farinazzo, M, Meli, R, Plaz Torres, M, Fanetti, I, Orellana, D, Zermiani, P, Zuin, M, De Bona, A, D'Arminio Monforte, A, Capretti, A, Taddei, M, Soncini, M, Spinetti, A, Zaltron, S, Pigozzi, M, Rossini, A, Pan, A, Dal Zoppo, S, Zoncada, A, Memoli, M, Salpietro, S, Hamid, H, Messina, E, Colombo, A, Giglio, O, Bonfanti, P, Molteni, C, Terreni, N, Spinzi, G, Conforti, S, Clerici, E, Menozzi, F, Buscarini, E, Centenaro, R, Corbellini, A, Noventa, F, Gritti, S, Giani, P, Fabbiani M., Lombardi A., Colaneri M., Del Poggio P., Perini P., D'Ambrosio R., Degasperi E., Dibenedetto C., Giorgini A., Pasulo L., Maggiolo F., Castelli F., Brambilla P., Spinelli O., Re T., Lleo A., Rumi M., Uberti-Foppa C., Soria A., Aghemo A., Lampertico P., Baiguera C., Schiavini M., Fagiuoli S., Bruno R., Borghi M., Soffredini R., Perbellini R., Gori A., Ferroni V., Colpani M., Manini M., Cologni G., Lazzaroni S., Vinci M., De Nicola S., Mazzarelli C., Angelini Zucchetti T., Picciotto V., Puoti M., Rossotti R., Landonio S., Magni C. F., Rizzardini G., Colella E., Columpsi P., Gambaro A., Spolti A., Magnani C., Vigano P., Mena M., Villa M., Caramma I., Basilico C., Capelli F., Biagiotti S., Mazzone A., Saladino V., Baldacci M. P., Gatti F., Varalli L., Morini L., Menzaghi B., Farinazzo M., Meli R., Plaz Torres M. C., Fanetti I., Orellana D., Zermiani P., Zuin M., De Bona A., D'Arminio Monforte A., Capretti A., Taddei M. T., Soncini M., Spinetti A., Zaltron S., Pigozzi M. G., Rossini A., Pan A., Dal Zoppo S., Zoncada A., Memoli M., Salpietro S., Hamid H., Messina E., Colombo A. E., Giglio O., Bonfanti P., Molteni C., Terreni N., Spinzi G., Conforti S., Clerici E., Menozzi F., Buscarini E., Centenaro R., Corbellini A., Noventa F., Gritti S., and Giani P.

Abstract

In routine clinical practice, hepatitis C virus-infected patients can prematurely discontinue the prescribed regimen for several reasons. The aim of our study was to investigate sustained virological response (SVR12) rates in patients who prematurely discontinued directly acting antiviral (DAA) regimens and to assess the shortest effective duration of DAA able to lead to SVR12. We retrospectively collected the SVR rates of patients, registered in the NAVIGATORE-Lombardia Network database from January 2015, who discontinued DAAs before the predefined end of treatment. Overall, we included 365 patients, males were the majority (213, 58.4%), mean age was 60.5 years, and 53 (14.5%) patients were HIV-co-infected. Liver cirrhosis was observed in 251 (68.8%) subjects, and the most represented genotypes were 1b (n = 168, 46%) and 3 (n = 59, 16.2%). DAA was discontinued a median of 1 (IQR 1–4) weeks before the predefined EOT, with 164 (44.9%) patients stopping DAAs at least 2 weeks before the planned schedule. In patients with F0–F3 liver fibrosis, lower rates of SVR12 were observed in patients treated for <4 weeks: 50% (n = 2/4) vs. 99.1% (n = 109/110) for ≥4 weeks, p = 0.003. In patients with liver cirrhosis, lower rates of SVR12 were observed in patients treated <8 weeks: 83.3% (n = 25/30) vs. 94.6% (n = 209/221) for ≥8 weeks, p = 0.038. Despite premature discontinuation of DAA, high SVR12 rates were observed in a real-life setting for treatment lasting at least 4 weeks in patients with liver fibrosis F0–F3 and 8 weeks in those with liver cirrhosis. On this basis, feasibility of reducing DAA treatment duration should be explored in randomized clinical trials.

Published
2021

6. The diagnostic contribution of CT volumetric rendering techniques in routine practice

Author

Perandini Simone, Faccioli N, Zaccarella A, Re T, and Mucelli R

Subjects
Computed tomography, CT, volume rendering, VR, MIP, MinIP, shaded surface display, virtual endoscopy, curved plane reconstructions, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Computed tomography (CT) volumetric rendering techniques such as maximum intensity projection (MIP), minimum intensity projection (MinIP), shaded surface display (SSD), volume rendering (VR), and virtual endoscopy (VE) provide added diagnostic capabilities. The diagnostic value of such reconstruction techniques is well documented in literature. These techniques permit the exploration of fine anatomical detail that would be difficult to evaluate using axial reconstructions alone. Although these techniques are now widely available, many radiologists are either unfamiliar with them or do not fully utilize their potential in daily clinical practice. This paper is intended to provide an overview of the most common CT volumetric rendering techniques and their practical use in everyday diagnostics.

Published
2010

8. FAKTOR-FAKTOR YANG MEMPENGARUHI KINERJA KARYAWAN PADA PT. TIMURJAYA DAYATAMA (WINGS) CABANG SONDER DIKABUPATEN MINAHASA

Author

Lontoh, Ersita T., Tewal, Bernhard, and Saerang, Re T.

Abstract

Karyawan adalah satu aset yang terpenting bagi Perusahaan dan Kinerja hasil kerja secara kauntitas dan kualitas yang dicapai sesuai dengan tanggung jawab yang diberikan kepadanya oleh sebab itu Kinerja Karyawan merupakan hal yang sangat penting dalam upaya perusahaan untuk mencapai tujuannya. Tujuan penelitian ini untuk mengetahui pengaruh Lingkungan Kerja, Motivasi Kerja dan Budaya Organisasi terhadap Kinerja Karyawan pada PT. Timurjaya Dayatamata (Wings) Cabang Sonder. Sampel dalam penelitian ini berjumlah 60 orang. Pengambilan data melalui Kuesioner. Analisis yang digunakan dalam penelitian ini adalah analisis regresi linier berganda. Hasil penelitian menunjukkan bahwa ada pengaruh signifikan dari Lingkungan Kerja terhadap Kinerja Karyawan, Motivasi Kerja terhadap Kinerja Karyawan, Budaya Organisasi terhadap Kinerja Karyawan. Bagi PT. Timurjaya Dayatama (WINGS) Cabang Sonder sebaiknya lebih meningkatkan Lingkungan Kerja, Motivasi Kerja dan Budaya Organisasi yang menjadi faktor determinan Kinerja Karyawan. Kata Kunci: Lingkungan kerja, motivasi kerja, budaya organisasi, kinerja karyawan

Published
2022

9. A QUALITATIVE ANALYSIS OF CONSUMER REPEATED PURCHASE BEHAVIOUR OF GRILL HOUSE MDC

Author

Hutadjulu, Revandro, Kindangen, Paulus, and Saerang, Re T.

Abstract

A repeat purchase is the act of repurchasing the same product or brand purchased earlier. These are often based on routine, habitual buying decisions, where the search for information around these purchases becomes limited over time. Consumer repeat purchase behavior can be influence by many factors whether it is because internal factors or external factors, it takes process to the company or some business to have a customer who purchase product repeatedly, especially for food business industry or those who wants or have a business of selling food. This research aims to know how is the Consumer Repeated Purchase Behavior of Grill House Mdc? What are the factors that drive Consumer Repeated Purchased Behavior on Customers of Grill House Mdc. In order to know this research using qualitative method, in-depth interview with 20 informants. To analyze the data this research uses several indicators which are Relationship Intimacy & Trust, Consumer Satisfaction, Quality of Service, Quality of Product, Pricing, and Consumer Needs. The results shows that Repeated purchased behavior comes and occur naturally when the customer of Grill House Mdc and Grill House Mdc having a very good relationship and the service and the product, all the responses from the informants is positive, all the informant 1-20 are very satisfy with the existence of Grill House Mdc..Keywords: repeat purchase, customer satisfaction

Published
2022

10. High rates of sustained virological response despite premature discontinuation of directly acting antivirals in HCV-infected patients treated in a real-life setting

Author

Fabbiani M., Lombardi A., Colaneri M., Del Poggio P., Perini P., D'Ambrosio R., Degasperi E., Dibenedetto C., Giorgini A., Pasulo L., Maggiolo F., Castelli F., Brambilla P., Spinelli O., Re T., Lleo A., Rumi M., Uberti-Foppa C., Soria A., Aghemo A., Lampertico P., Baiguera C., Schiavini M., Fagiuoli S., Bruno R., Borghi M., Soffredini R., Perbellini R., Gori A., Ferroni V., Colpani M., Manini M., Cologni G., Lazzaroni S., Vinci M., De Nicola S., Mazzarelli C., Angelini Zucchetti T., Picciotto V., Puoti M., Rossotti R., Landonio S., Magni C. F., Rizzardini G., Colella E., Columpsi P., Gambaro A., Spolti A., Magnani C., Vigano P., Mena M., Villa M., Caramma I., Basilico C., Capelli F., Biagiotti S., Mazzone A., Saladino V., Baldacci M. P., Gatti F., Varalli L., Morini L., Menzaghi B., Farinazzo M., Meli R., Plaz Torres M. C., Fanetti I., Orellana D., Zermiani P., Zuin M., De Bona A., D'Arminio Monforte A., Capretti A., Taddei M. T., Soncini M., Spinetti A., Zaltron S., Pigozzi M. G., Rossini A., Pan A., Dal Zoppo S., Zoncada A., Memoli M., Salpietro S., Hamid H., Messina E., Colombo A. E., Giglio O., Bonfanti P., Molteni C., Terreni N., Spinzi G., Conforti S., Clerici E., Menozzi F., Buscarini E., Centenaro R., Corbellini A., Noventa F., Gritti S., Giani P., Fabbiani, Massimiliano, Lombardi, Andrea, Colaneri, Marta, Del Poggio, Paolo, Perini, Paolo, D'Ambrosio, Roberta, Degasperi, Elisabetta, Dibenedetto, Clara, Giorgini, Alessia, Pasulo, Luisa, Maggiolo, Franco, Castelli, Francesco, Brambilla, Paola, Spinelli, Ombretta, Tiziana, Re, Lleo, Ana, Rumi, Mariagrazia, Uberti-Foppa, Caterina, Soria, Alessandro, Aghemo, Alessio, Lampertico, Pietro, Baiguera, Chiara, Schiavini, Monica, Fagiuoli, Stefano, Bruno, Raffaele, Fabbiani, M, Lombardi, A, Colaneri, M, Del Poggio, P, Perini, P, D'Ambrosio, R, Degasperi, E, Dibenedetto, C, Giorgini, A, Pasulo, L, Maggiolo, F, Castelli, F, Brambilla, P, Spinelli, O, Re, T, Lleo, A, Rumi, M, Uberti-Foppa, C, Soria, A, Aghemo, A, Lampertico, P, Baiguera, C, Schiavini, M, Fagiuoli, S, Bruno, R, Borghi, M, Soffredini, R, Perbellini, R, Gori, A, Ferroni, V, Colpani, M, Manini, M, Cologni, G, Lazzaroni, S, Vinci, M, De Nicola, S, Mazzarelli, C, Angelini Zucchetti, T, Picciotto, V, Puoti, M, Rossotti, R, Landonio, S, Magni, C, Rizzardini, G, Colella, E, Columpsi, P, Gambaro, A, Spolti, A, Magnani, C, Vigano, P, Mena, M, Villa, M, Caramma, I, Basilico, C, Capelli, F, Biagiotti, S, Mazzone, A, Saladino, V, Baldacci, M, Gatti, F, Varalli, L, Morini, L, Menzaghi, B, Farinazzo, M, Meli, R, Plaz Torres, M, Fanetti, I, Orellana, D, Zermiani, P, Zuin, M, De Bona, A, D'Arminio Monforte, A, Capretti, A, Taddei, M, Soncini, M, Spinetti, A, Zaltron, S, Pigozzi, M, Rossini, A, Pan, A, Dal Zoppo, S, Zoncada, A, Memoli, M, Salpietro, S, Hamid, H, Messina, E, Colombo, A, Giglio, O, Bonfanti, P, Molteni, C, Terreni, N, Spinzi, G, Conforti, S, Clerici, E, Menozzi, F, Buscarini, E, Centenaro, R, Corbellini, A, Noventa, F, Gritti, S, and Giani, P

Subjects
Simeprevir, Male, medicine.medical_specialty, Cirrhosis, SVR, Sofosbuvir, Sustained Virologic Response, liver cirrhosis, antiviral treatment, Hepacivirus, Antiviral Agents, law.invention, Randomized controlled trial, law, Virology, Internal medicine, Medicine, Humans, chronic hepatitis C, Prospective cohort study, DAA, Retrospective Studies, Hepatology, liver cirrhosi, business.industry, Hepatitis C, Hepatitis C, Chronic, Middle Aged, medicine.disease, Discontinuation, Regimen, Infectious Diseases, Treatment Outcome, business, medicine.drug
Abstract

In routine clinical practice, hepatitis C virus-infected patients can prematurely discontinue the prescribed regimen for several reasons. The aim of our study was to investigate sustained virological response (SVR12) rates in patients who prematurely discontinued directly acting antiviral (DAA) regimens and to assess the shortest effective duration of DAA able to lead to SVR12. We retrospectively collected the SVR rates of patients, registered in the NAVIGATORE-Lombardia Network database from January 2015, who discontinued DAAs before the predefined end of treatment. Overall, we included 365 patients, males were the majority (213, 58.4%), mean age was 60.5years, and 53 (14.5%) patients were HIV-co-infected. Liver cirrhosis was observed in 251 (68.8%) subjects, and the most represented genotypes were 1b (n=168, 46%) and 3 (n=59, 16.2%). DAA was discontinued a median of 1 (IQR 1–4) weeks before the predefined EOT, with 164 (44.9%) patients stopping DAAs at least 2weeks before the planned schedule. In patients with F0–F3 liver fibrosis, lower rates of SVR12 were observed in patients treated for

Published
2021

13. Rayleigh-Taylor instability during impact cratering experiments

Author

Lherm, V., Deguen, R., Alboussi��re, T., and Landeau, M.

Subjects
Physics::Fluid Dynamics, Physics - Geophysics, Fluid Dynamics (physics.flu-dyn), FOS: Physical sciences, Astrophysics::Earth and Planetary Astrophysics, Physics - Fluid Dynamics, Geophysics (physics.geo-ph)
Abstract

When a liquid drop strikes a deep pool of a second liquid, an impact crater opens while the liquid of the drop decelerates and spreads on the surface of the crater. If the density of the drop is larger than the surrounding, the interface between the drop liquid layer and its surrounding becomes unstable, producing mushroom-shaped plumes growing radially outward. We interpret this instability as a spherical Rayleigh-Taylor instability associated with the deceleration of the interface between the drop and its surrounding, which significantly exceeds the ambient vertical gravity. We investigate experimentally how changing the density contrast and the impact Froude number affects the instability and the resulting mixing layer. Using backlighting and planar laser-induced fluorescence methods, the position of the air-liquid interface, the thickness of the mixing layer, and an estimate of the instability wavelength are obtained. First, the evolution of the mean crater radius is derived from an energy conservation model. The observed mixing layer dynamics is then explained by a model involving a competition between the geometrical expansion of the crater tending to decrease its thickness, and mixing produced by the Rayleigh-Taylor instability tending to increase its thickness. The estimated instability wavelength is finally compared to an approximate linear stability analysis of a radially accelerated fluid sphere into a less dense fluid. Mixing properties of this impact-related instability have geophysical implications regarding the differentiation of terrestrial planets, in particular by estimating the mass of magma ocean silicates that equilibrates with the metal core of the impacting planetesimals.

Published
2020

21. Long-term efficacy of dolutegravir in treatment-experienced subjects failing therapy with HIV-1 integrase strand inhibitor-resistant virus

Author

Castagna, A., Ferrara, M., Galli, L., Comi, L., Sterrantino, G., Cenderello, G., Zaccarelli, M., Focà, E., Roncadori, A., Lazzarin, A., Chichino, G., Mantia, E., Butini, L., Costantini, A., Giacometti, A., Tavio, M., Grassini, M., Valle, M., Vaccher, E., Martellotta, F., Schioppa, O., Maggiolo, F., Viale, P., Borderi, M., Calza, L., Moratello, L., Magistrelli, E., Castelli, F., Festa, E., Quirino, T., Campus, M., Businco, F., Celesia, B. M., La Rosa, R., Pan, A., Fornabaio, C., Mazzotta, F., Di Pietro, M., Bartoloni, A., Ferrara, S., Mastroianni, A., Di Cesare, S., Viscoli, C., Di Biagio, A., Cassola, G., Penco, G., Cericola, A, Nencioni, C., Carli, T., Viganò, P., Re, T., Del Fiorentino, A., Gattuso, G., Palvarini, L., Taurozzi, M., Gianotti, N., Galizzi, N., Poli, A., Rusconi, S., Salvaggio, S. E., Galli, M., Rizzardini, G., Mussini, C., Menozzi, M., Gori, A., Muscatello, A., Cappelletti, E., Gargiulo, M., Garavelli, P. L., Bargiacchi, O., Prestileo, T., Di Lorenzo, F., Bonanno, S., Ferrari, C., degli Antoni, A. M., Cattelan, A. M., Gulminetti, R., Pagnucco, L., Menichetti, F., Iapoce, R., Baldelli, F., Schiaroli, E., Italiani, F., Aquilini, D., Magnani, G., Corsini, R., Barchi, E., Ferrari, E., Antinori, A., Cristaudo, A., Latini, A., Cauda, R., Vullo, V., Maffongelli, G., Andreoni, M., Sassett, L., Viviani, F., De Luca, A., Rossetti, B., Franco, A., Resta, F., Di Perri, G., Bonora, S., Bassetti, M., Londero, A., Malena, M., Luzzati, Roberto, Castagna, A., Ferrara, M., Galli, L., Comi, L., Sterrantino, G., Cenderello, G., Zaccarelli, M., Focà, E., Roncadori, A., Lazzarin, A., Chichino, G., Mantia, E., Butini, L., Costantini, A., Giacometti, A., Tavio, M., Grassini, M., Valle, M., Vaccher, E., Martellotta, F., Schioppa, O., Maggiolo, F., Viale, P., Borderi, M., Calza, L., Moratello, L., Magistrelli, E., Castelli, F., Festa, E., Quirino, T., Campus, M., Businco, F., Celesia, B. M., La Rosa, R., Pan, A., Fornabaio, C., Mazzotta, F., Di Pietro, M., Bartoloni, A., Ferrara, S., Mastroianni, A., Di Cesare, S., Viscoli, C., Di Biagio, A., Cassola, G., Penco, G., Cericola, A, Nencioni, C., Carli, T., Viganò, P., Re, T., Del Fiorentino, A., Gattuso, G., Palvarini, L., Taurozzi, M., Gianotti, N., Galizzi, N., Poli, A., Rusconi, S., Salvaggio, S. E., Galli, M., Rizzardini, G., Mussini, C., Menozzi, M., Gori, A., Muscatello, A., Cappelletti, E., Gargiulo, M., Garavelli, P. L., Bargiacchi, O., Prestileo, T., Di Lorenzo, F., Bonanno, S., Ferrari, C., degli Antoni, A. M., Cattelan, A. M., Gulminetti, R., Pagnucco, L., Menichetti, F., Iapoce, R., Baldelli, F., Schiaroli, E., Italiani, F., Aquilini, D., Magnani, G., Corsini, R., Barchi, E., Ferrari, E., Antinori, A., Cristaudo, A., Latini, A., Cauda, R., Vullo, V., Maffongelli, G., Andreoni, M., Sassett, L., Viviani, F., De Luca, A., Rossetti, B., Franco, A., Resta, F., Di Perri, G., Bonora, S., Bassetti, M., Londero, A., Malena, M., and Luzzati, Roberto

Subjects
HIV, dolutegravir, efficacy, Male, Anti-HIV Agents, Pyridones, Drug Resistance, HIV Infections, HIV Integrase, 3-Ring, Piperazines, Coinfection, Drug Resistance, Viral, Drug Therapy, Combination, Female, HIV Integrase Inhibitors, HIV-1, Hepatitis C, Chronic, Heterocyclic Compounds, 3-Ring, Humans, Middle Aged, Treatment Outcome, Viral Load, Drug Therapy, Heterocyclic Compounds, Oxazines, Pharmacology (medical), Viral, Chronic, Pharmacology, Pharmacology, Pharmacology (medical), Infectious Diseases, Hepatitis C, Infectious Diseases, Combination
Abstract

OBJECTIVES: This study evaluated the virological efficacy of dolutegravir 50 mg twice daily in 190 HIV-1 failing antiretroviral-experienced patients with previous exposure to first-generation integrase strand transfer inhibitor (INSTI) over a 5 year follow-up using data from clinical practice. PATIENTS AND METHODS: This analysis included HIV-1-infected patients who were ≥18 years of age, treatment experienced, had HIV-1 RNA >50 copies/mL, with INSTI-resistant virus, who started dolutegravir 50 mg twice daily plus optimized background therapy (OBT), recorded in the national prospective database PRESTIGIO (www.progettoprestigio.it). Follow-up accrued from the start of dolutegravir 50 mg twice daily + OBT until virological failure (VF) or dolutegravir discontinuation for any reason or the last treatment visit on dolutegravir 50 mg twice daily treatment. VF was defined by the lack of achievement of HIV-1 RNA 100000 copies/mL (adjusted HR = 4.73, 95% CI = 1.33-16.78, P = 0.016) and with ≥1 INSTI mutations plus Q148H/K/R/N and the G140S/A/C as compared with other subjects (adjusted HR = 4.18, 95% CI = 1.32-13.23, P = 0.015). CONCLUSIONS: Our data showed a favourable long-term efficacy of dolutegravir 50 mg twice daily in association with OBT in treatment-experienced failing subjects, with INSTI-resistant virus, in the real world. A close monitoring of adherence is crucial for maintenance of virological response in this fragile subgroup of subjects.

Published
2018

22. Impact of HBV infection in HCV/HBV coinfected patients treated with DAAs IN Northern Italy

Author

Fabris, P., primary, Noventa, F., additional, Pasulo, L., additional, Farina, F., additional, Carollo, G., additional, Carlotto, A., additional, Rovere, P., additional, Cavinato, S., additional, Romano, A., additional, Vario, A., additional, Fraceschet, I., additional, Panese, S., additional, Bertin, T., additional, Zappalà, F., additional, Alberti, A., additional, Lobello, S., additional, Aghemo, A., additional, Bruno, R., additional, Puoti, M., additional, Rizzardini, G., additional, Spinelli, O., additional, Pigozzi, MG., additional, Spinetti, A., additional, Menzaghi, B., additional, Pan, A., additional, Bella, D., additional, Re, T., additional, Borghi, M., additional, Lombardi, A., additional, Viganò, M., additional, Salpietro, S., additional, Lleo, A., additional, and Fagiuoli, S., additional

Published
2020
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24. HIV clinical pathway: A new approach to combine guidelines and sustainability of anti-retroviral treatment in Italy

Author

Croce, D, Lazzarin, A, Rizzardini, G, Gianotti, N, Scolari, F, Foglia, E, Garagiola, E, Ricci, E, Bini, T, Quirino, T, Vigano, P, Re, T, Monforte, A, Bonfanti, P, Croce D., Lazzarin A., Rizzardini G., Gianotti N., Scolari F., Foglia E., Garagiola E., Ricci E., Bini T., Quirino T., Vigano P., Re T., Monforte A. D., Bonfanti P., Croce, D, Lazzarin, A, Rizzardini, G, Gianotti, N, Scolari, F, Foglia, E, Garagiola, E, Ricci, E, Bini, T, Quirino, T, Vigano, P, Re, T, Monforte, A, Bonfanti, P, Croce D., Lazzarin A., Rizzardini G., Gianotti N., Scolari F., Foglia E., Garagiola E., Ricci E., Bini T., Quirino T., Vigano P., Re T., Monforte A. D., and Bonfanti P.

Abstract

The present article describes the case study of a "real world" HIV practice within the debate concerning the strategic role of Clinical Governance (CG) tools in the management of a National Healthcare System's sustainability. The study aimed at assessing the impact of a Clinical Pathway (CP) implementation, required by the Regional Healthcare Service, in terms of effectiveness (virological and immunological conditions) and efficiency (economic resources absorption), from the budget holder perspective. Data derived from a multi-centre cohort of patients treated in 6 Hospitals that provided care to approximately 42% of the total HIV+ patients, in Lombardy Region, Italy. Two phases were compared: Pre-CP (2009-2010) vs. Post-CP implementation (2011-2012). All HIV infected adults, observed in the participating hospitals during the study periods, were enrolled and stratified into the 3 categories defined by the Regional CP: first-line, switch for toxicity/other, and switch for failure. The study population was composed of 1,284 patients (Pre-CP phase) and 1,135 patients (Post-CP phase). The results showed that the same level of virological and immunological effectiveness was guaranteed to HIV+ patients: 81.2% of Pre-CP phase population and 83.2% of Post-CP phase population had undetectable HIV-RNA (defined as <50 copies/mL) at 12-month follow up. CD4+ cell counts increased by 28 ± 4 cells/mm3 in Pre-CP Phase and 39 ± 5 cells/mm3 in Post-CP Phase. From an economic point of view, the CP implementation led to a substantial advantage: the mean total costs related to the management of the HIV disease (ART, hospital admission and laboratory tests) decreased (-8.60%) in the Post-CP phase (p-value < 0.0001). Results confirmed that the CP provided appropriateness and quality of care, with a cost reduction for the budget holder.

Published
2016

25. Storage of RF photons in minimal conditions

Author

Cromi��res, J. -P., Chaneli��re, T., Laboratoire Aimé Cotton (LAC), and Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-École normale supérieure - Cachan (ENS Cachan)

Subjects
[PHYS.PHYS.PHYS-CLASS-PH]Physics [physics]/Physics [physics]/Classical Physics [physics.class-ph], Quantum Physics, [PHYS.PHYS]Physics [physics]/Physics [physics], Atomic Physics (physics.atom-ph), Classical Physics (physics.class-ph), FOS: Physical sciences, Physics - Classical Physics, Quantum Physics (quant-ph), ComputingMilieux_MISCELLANEOUS, Physics - Atomic Physics
Abstract

We investigate the minimal conditions to store coherently a RF pulse in a material medium. We choose a commercial quartz as memory support because it is a widely available component with a high Q-factor. Pulse storage is obtained by varying dynamically the light-matter coupling with an analog switch. This parametric driving of the quartz dynamics can be alternatively interpreted as a stopped light experiment. We obtain an efficiency of 26%, a storage time of 209$\mu$s and a time-to-bandwidth product of 98 by optimizing the pulse temporal shape. The coherent character of the storage is demonstrated. Our goal is to connect different types of memories in the RF and optical domain for quantum information processing. Our motivation is essentially fundamental.

Published
2018
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26. Neurotheology of islam and higher consciousness states

Author

Bragazzi, N. L., Khabbache Hicham, Vecchio, I., Martini, M., Zerbetto, R., and Re, T. S.

Subjects
Consciousness states, Islam, Neurotheology, Sufism, Philosophy, Consciousness states, Philosophy, Sufism, Islam, Neurotheology
Published
2018

27. HCV infection is a risk factor for gallstone disease in liver cirrhosis: an Italian epidemiological survey

Author

Stroffolini, T., Sagnelli, E., Mele, A., Cottone, C., Almasio, P. L., Traverso, A., Arrigoni, A., Torchio, M., Garbagnoli, P., Del Mastro, B., Romano, P., Vanni, R., Brusita, D., Meucci, P., Cassola, G., Borzio, M., Bellobuono, A., De Bona, A., Re, T., Del Poggio, P., Baisini, O., Colombo, A., Attolini, C., Daria, S., MINOLI, MARIA LAURA, Gazzaniga, V., Segato, S., ORIOLO, MARIA, Parlotto, A., Ghersetti, M., CAPRA, FRANCESCA, Muratori, R., Sama, C., BOCCIA, SARA, Verdianelli, G., PRATICO', ANTONIO, GRANDI, MARIO, VENTURA, ELISA, Cantoni, F., Vincenti, A., Nerli Alessandro, A., Galeazzi, L., SOLINAS, ALICE, Paroli, M., De Sanctis, G. M., Sereno, S., Clementi, C., Visco Comandino, U., Gallo, A. I., Festi, D., Sabusco, G., Coppola, N., Scolastico, C., Onofrio, M., Imparato, M., Filippini, P., Morisco, F., Liberti, A., BORGIA, GIULIO CESARE, Scarpellino, F., Persico, M., Sagnelli, C., COPPOLA, CLAUDIO, Caserta, L., Elia, A., De Vita, G., Lanzotti, A., Pizzolante, L., Messina, V., Fiore, G., Agostinacchio, E., Santantonio, T., Mazzola, M., Vinelli, F., Campagna, A., Cataldini, S., Monelli, I., Lascaro, M., Polimeri, N., Frugiuele, P., Ferraro, M., Prestileo, T., Alessandri, A., Russello Maurizio, M., Bellissima, P., Orifici, G., Pisani, G., Angioini, S., Lai, M., Spanneda, M., Stroffolini, T., Sagnelli, E., Mele, A., Cottone, C., Almasio, P.L., Traverso, A., Arrigoni, A., Torchio, M., Garbagnoli, P., Del Mastro, B., Romano, P., Vanni, R., Brusita, D., Meucci, P., Cassola, G., Borzio, M., Bellobuono, A., De Bona, A., Re, T., Del Poggio, P., Baisini, O., Colombo, A., Attolini, C., Daria, S., Minoli, L., Gazzaniga, V., Segato, S., Oriolo, M., Parlotto, A., Ghersetti, M., Capra, F., Muratori, R., Sama, C., Boccia, S., Verdianelli, G., Praticò, A., Grandi, M., Ventura, E., Cantoni, F., Vincenti, A., Nerli Alessandro, A., Galeazzi, L., Solinas, A., Paroli, M., De Sanctis, G.M., Sereno, S., Clementi, C., Visco Comandino, U., Gallo, A.I., Festi, D., Sabusco, G., Coppola, N., Scolastico, C., Onofrio, M., Imparato, M., Filippini, P., Morisco, F., Liberti, A., Borgia, G., Scarpellino, F., Persico, M., Sagnelli, C., Coppola, C., Caserta, L., Elia, A., De Vita, G., Lanzotti, A., Pizzolante, L., Messina, V., Fiore, G., Agostinacchio, E., Santantonio, T., Mazzola, M., Vinelli, F., Campagna, A., Cataldini, S., Monelli, I., Lascaro, M., Polimeri, N., Frugiuele, P., Ferraro, M., Prestileo, T., Alessandri, A., Russello Maurizio, M., Bellissima, P., Orifici, G., Pisani, G., Angioini, S., Lai, M., and Spanneda, M.

Subjects
Liver Cirrhosis, Adult, Male, HBsAg, medicine.medical_specialty, Cirrhosis, Alcohol Drinking, Liver Cirrhosi, Gallbladder disease, Prevalence, Infectious Disease, Gallstones, Gastroenterology, Liver disease, Risk Factors, Virology, Internal medicine, HBV, medicine, Humans, Cholecystectomy, Risk factor, Aged, Cirrhosi, Hepatology, business.industry, Risk Factor, Hepatitis C, Hepatitis C, Chronic, Middle Aged, medicine.disease, Infectious Diseases, Italy, Gallstone, HCV, Chronic hepatiti, Female, business, Human
Abstract

We assessed the prevalence of gallbladder disease (i.e. gallstones plus cholecystectomy) among patients with liver disease and its association with the severity and aetiology of hepatic injury. Subjects, referred to 79 Italian hospitals, were enrolled in a 6-month period. The independent effect of the severity and aetiology of liver disease on gallstone disease prevalence was assessed by multiple logistic regression analysis. Overall, 4867 subjects tested anti-hepatitis C virus (HCV) positive alone, 839 were hepatitis B virus surface antigen (HBsAg) alone, and 652 had an excessive alcohol intake. The prevalence of gallstone disease was 23.3% in anti-HCV-positive patients, 12.4% in HBsAg positive and 24.2% in subjects reporting excessive alcohol intake, respectively. Gallstone disease prevalence increased by age in each aetiological category. The proportion of patients with gallstone disease who had a cholecystectomy was the highest in HCV+ subjects. After adjusting for the confounding effect of age and body mass index, compared with patients with less severe liver disease, subjects with HCV-related cirrhosis, but not those with alcohol-related cirrhosis, were more likely to have gallstone disease. Subjects with HCV-related cirrhosis (OR 2.13, 95% CI: 1.38-3.26) were more likely to have gallstone disease when compared with those with HBV-related cirrhosis. HCV infection is a risk factor for gallstone disease. In Italy, the high prevalence of HCV infection among cirrhotic patients has important implications, as cholecystectomy in these subjects is associated with high risk of morbidity and mortality. © 2007 The Authors.

Published
2007
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31. Clinical Features of Bacterial Meningitis in Italy: a Multicenter Prospective Observational Study

Author

Lazzarini, L., Toti, M., Fabris, P., Conti, E., Magni, G., Mazzotta, F., Lalla, F., Acone, N., Aquila, G., Pastore, G., Buongiorno, R., Francavilla, E., Granata, C., Maio, G., Sangiuolo, A., Andreoni, M., Bellissima, P., Russo, R., Tosto, S., Stagno, A., Beltrami, C., Brighi, S., Guaglianone, L., Luciani, F., Carnevale, G., Viganò, P., Re, T., Fiore, M., Ciao, V., Padovani, P., Ghinelli, F., Bicocchi, R., Leoncini, F., Pozzi, M., Gioacchino ANGARANO, Scotto, G., Palumbo, E., Cancellieri, C., Pagano, G., Camera, M., Cassola, G., Giomi, S., Iannessi, A., Cellini, A., Soscia, F., Salone, G., Rovere, P., Scasso, A., Chiodera, A., Todaro, G., Orifici, G., Moroni, M., Negri, C., Cargnel, A., Gubertini, G., Bisoffi, Z., Marocco, S., Sapienza, M., Benenati, P., Colucci, M., Giordano, G., Baldelli, F., Di Candilo, F., Alberici, F., Ratti, G., Zauli, T., Foti, G., Magnani, G., Rossi, G., Arlotti, M., Ortolani, P., Petrosillo, N., Renda, V., Iaiani, G., Narciso, P., Ghirga, P., Paffetti, A., Mannozzi, P., Vullo, V., Massetti, A. P., Carretta, M., Viviani, F., Frongillo, R. F., Palumbo, M., Caramello, P., Gaiottino, F., Viale, P., Crapis, M., Grossi, P., Dinatale, Poggio, A., and Mondino, V.

Subjects
Male, Time Factors, Neisseria meningitidis, medicine.disease_cause, Severity of Illness Index, Ampicillin, 80 and over, Pharmacology (medical), Prospective Studies, Antibacterial agent, Aged, 80 and over, ampicillin, ceftriaxone, italy, meningitis, steroids, Respiration, Ceftriaxone, Bacterial, Middle Aged, Anti-Bacterial Agents, Streptococcus pneumoniae, Infectious Diseases, Italy, Oncology, Combination, Artificial, Meningitis, Steroids, Adolescent, Adult, Aged, Drug Therapy, Combination, Female, Glucocorticoids, Humans, Length of Stay, Meningitis, Bacterial, Respiration, Artificial, Young Adult, Pharmacology, medicine.drug, Meningitides, medicine.medical_specialty, Drug Therapy, Internal medicine, medicine, business.industry, medicine.disease, Surgery, Adjunctive treatment, business
Abstract

We carried out a prospective observational study on clinical features of bacterial meningitis. Between October 2002 and June 2005, 322 adult bacterial meningitis cases in 49 infectious disease wards in Italy (MENTORE study group) were enrolled in the study. 133 cases were due to Streptococcus pneumoniae, 44 to Neisseria meningitidis and 145 to other microorganisms. A high SAPS score and coma on admission, as well as need for mechanical ventilation, were more frequent in the pneumococcal meningitis group. Neurological impairment was present in 151 out of 311 patients, and was more frequent in pneumococcal meningitis. A single antibiotic was employed in only 90 of 315 cases; a combination of ceftriaxone and ampicillin was the most frequently administered treatment. Ceftriaxone was also the single most used drug. Adjunctive treatment with steroids was administered in 210 out of 303 patients for a median duration of 7 days. Median duration of fever was 4 days, and median hospital stay was 16 days; hospitalization was significantly longer in the pneumococcal meningitis group. At discharge, neurological impairment was still present in 59 (21%) of 277 patients. Twenty (6.9%) out of 289 patients died during hospitalization. Distribution of adverse outcome (death and neurological impairment) in patients treated with or without steroids and within different time zones between onset of symptoms and commencement of antibiotics was studied; a trend toward a worse prognosis was seen in patients treated more than 24 hours after onset of the disease.In our study, infectious disease clinicians made extensive use of steroids as adjuvant therapy for bacterial meningitis, even in absence of detailed national and local guidelines. Mortality seemed to be lower in comparison with the literature.

Published
2008
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32. JUNO Conceptual Design Report

Author

Adam, T., An, F., An, G., An, Q., Anfimov, N., Antonelli, V., Baccolo, G., Baldoncini, M., Baussan, E., Bellato, M., Bezrukov, L., Bick, D., Blyth, S., Boarin, S., Brigatti, A., Brugi��re, T., Brugnera, R., Avanzini, M. Buizza, Busto, J., Cabrera, A., Cai, H., Cai, X., Cammi, A., Cao, D., Cao, G., Cao, J., Chang, J., Chang, Y., Chen, M., Chen, P., Chen, Q., Chen, S., Chen, X., Chen, Y., Cheng, Y., Chiesa, D., Chukanov, A., Clemenza, M., Clerbaux, B., D'Angelo, D., de Kerret, H., Deng, Z., Ding, X., Ding, Y., Djurcic, Z., Dmitrievsky, S., Dolgareva, M., Dornic, D., Doroshkevich, E., Dracos, M., Drapier, O., Dusini, S., D��az, M. A., Enqvist, T., Fan, D., Fang, C., Fang, J., Fang, X., Favart, L., Fedoseev, D., Fiorentini, G., Ford, R., Formozov, A., Gaigher, R., Gan, H., Garfagnini, A., Gaudiot, G., Genster, C., Giammarchi, M., Giuliani, F., Gonchar, M., Gong, G., Gong, H., Gonin, M., Gornushkin, Y., Grassi, M., Grewing, C., Gromov, V., Gu, M., Guan, M., Guarino, V., Guo, W., Guo, X., Guo, Y., G��ger-Neff, M., Hackspacher, P., Hagner, C., Han, R., Han, Z., Hao, J., He, M., Hellgartner, D., Heng, Y., Hong, D., Hou, S., Hsiung, Y., Hu, B., Hu, J., Hu, S., Hu, T., Hu, W., Huang, H., Huang, X., Huo, L., Huo, W., Ioannisian, A., Ioannisyan, D., Jeitler, M., Jen, K., Jetter, S., Ji, X., Jian, S., Jiang, D., Jiang, X., Jollet, C., Kaiser, M., Kan, B., Kang, L., Karagounis, M., Kazarian, N., Kettell, S., Korablev, D., Krasnoperov, A., Krokhaleva, S., Krumshteyn, Z., Kruth, A., Kuusiniemi, P., Lachenmaier, T., Lei, L., Lei, R., Lei, X., Leitner, R., Lenz, F., Li, C., Li, F., Li, J., Li, N., Li, S., Li, T., Li, W., Li, X., Li, Y., Li, Z., Liang, H., Liang, J., Licciardi, M., Lin, G., Lin, S., Lin, T., Lin, Y., Lippi, I., Liu, G., Liu, H., Liu, J., Liu, Q., Liu, S., Liu, Y., Lombardi, P., Long, Y., Lorenz, S., Lu, C., Lu, F., Lu, H., Lu, J., Lubsandorzhiev, B., Lubsandorzhiev, S., Ludhova, L., Luo, F., Luo, S., Lv, Z., Lyashuk, V., Ma, Q., Ma, S., Ma, X., Malyshkin, Y., Mantovani, F., Mao, Y., Mari, S., Mayilyan, D., McDonough, W., Meng, G., Meregaglia, A., Meroni, E., Mezzetto, M., Min, J., Miramonti, L., Montuschi, M., Morozov, N., Mueller, T., Muralidharan, P., Nastasi, M., Naumov, D., Naumova, E., Nemchenok, I., Ning, Z., Nunokawa, H., Oberauer, L., Ochoa-Ricoux, J. P., Olshevskiy, A., Ortica, F., Pan, H., Paoloni, A., Parkalian, N., Parmeggiano, S., Pec, V., Pelliccia, N., Peng, H., Poussot, P., Pozzi, S., Previtali, E., Prummer, S., Qi, F., Qi, M., Qian, S., Qian, X., Qiao, H., Qin, Z., Ranucci, G., Re, A., Ren, B., Ren, J., Rezinko, T., Ricci, B., Robens, M., Romani, A., Roskovec, B., Ruan, X., Rybnikov, A., Sadovsky, A., Saggese, P., Salamanna, G., Sawatzki, J., Schuler, J., Selyunin, A., Shi, G., Shi, J., Shi, Y., Sinev, V., Sirignano, C., Sisti, M., Smirnov, O., Soiron, M., Stahl, A., Stanco, L., Steinmann, J., Strati, V., Sun, G., Sun, X., Sun, Y., Taichenachev, D., Tang, J., Tietzsch, A., Tkachev, I., Trzaska, W. H., Tung, Y., van Waasen, S., Volpe, C., Vorobel, V., Votano, L., Wang, C., Wang, G., Wang, H., Wang, M., Wang, R., Wang, S., Wang, W., Wang, Y., Wang, Z., Wei, W., Wei, Y., Weifels, M., Wen, L., Wen, Y., Wiebusch, C., Wipperfurth, S., Wong, S. C., Wonsak, B., Wu, C., Wu, Q., Wu, Z., Wurm, M., Wurtz, J., Xi, Y., Xia, D., Xia, J., Xiao, M., Xie, Y., Xu, J., Xu, L., Xu, Y., Yan, B., Yan, X., Yang, C., Yang, H., Yang, L., Yang, M., Yang, Y., Yanovich, E., Yao, Y., Ye, M., Ye, X., Yegin, U., Yermia, F., You, Z., Yu, B., Yu, C., Yu, G., Yu, Z., Yuan, Y., Yuan, Z., Zanetti, M., Zeng, P., Zeng, S., Zeng, T., Zhan, L., Zhang, C., Zhang, F., Zhang, G., Zhang, H., Zhang, J., Zhang, K., Zhang, P., Zhang, Q., Zhang, T., Zhang, X., Zhang, Y., Zhang, Z., Zhao, J., Zhao, M., Zhao, T., Zhao, Y., Zheng, H., Zheng, M., Zheng, X., Zheng, Y., Zhong, W., Zhou, G., Zhou, J., Zhou, L., Zhou, N., Zhou, R., Zhou, S., Zhou, W., Zhou, X., Zhou, Y., Zhu, H., Zhu, K., Zhuang, H., Zong, L., and Zou, J.

Subjects
High Energy Physics - Experiment (hep-ex), Physics - Instrumentation and Detectors, hep-ex, Physics::Instrumentation and Detectors, FOS: Physical sciences, High Energy Physics::Experiment, Instrumentation and Detectors (physics.ins-det), physics.ins-det, High Energy Physics - Experiment
Abstract

The Jiangmen Underground Neutrino Observatory (JUNO) is proposed to determine the neutrino mass hierarchy using an underground liquid scintillator detector. It is located 53 km away from both Yangjiang and Taishan Nuclear Power Plants in Guangdong, China. The experimental hall, spanning more than 50 meters, is under a granite mountain of over 700 m overburden. Within six years of running, the detection of reactor antineutrinos can resolve the neutrino mass hierarchy at a confidence level of 3-4$\sigma$, and determine neutrino oscillation parameters $\sin^2\theta_{12}$, $\Delta m^2_{21}$, and $|\Delta m^2_{ee}|$ to an accuracy of better than 1%. The JUNO detector can be also used to study terrestrial and extra-terrestrial neutrinos and new physics beyond the Standard Model. The central detector contains 20,000 tons liquid scintillator with an acrylic sphere of 35 m in diameter. $\sim$17,000 508-mm diameter PMTs with high quantum efficiency provide $\sim$75% optical coverage. The current choice of the liquid scintillator is: linear alkyl benzene (LAB) as the solvent, plus PPO as the scintillation fluor and a wavelength-shifter (Bis-MSB). The number of detected photoelectrons per MeV is larger than 1,100 and the energy resolution is expected to be 3% at 1 MeV. The calibration system is designed to deploy multiple sources to cover the entire energy range of reactor antineutrinos, and to achieve a full-volume position coverage inside the detector. The veto system is used for muon detection, muon induced background study and reduction. It consists of a Water Cherenkov detector and a Top Tracker system. The readout system, the detector control system and the offline system insure efficient and stable data acquisition and processing., Comment: 328 pages, 211 figures

Published
2015

33. Measurement of $��_{13}$ in Double Chooz using neutron captures on hydrogen with novel background rejection techniques

Author

Abe, Y., Appel, S., Abrah��o, T., Almazan, H., Alt, C., Anjos, J. C. dos, Barriere, J. C., Baussan, E., Bekman, I., Bergevin, M., Bezerra, T. J. C., Bezrukov, L., Blucher, E., Brugi��re, T., Buck, C., Busenitz, J., Cabrera, A., Camilleri, L., Carr, R., Cerrada, M., Chauveau, E., Chimenti, P., Collin, A. P., Conrad, J. M., Crespo-Anad��n, J. I., Crum, K., Cucoanes, A. S., Damon, E., Dawson, J. V., Dhooghe, J., Dietrich, D., Djurcic, Z., Dracos, M., Etenko, A., Fallot, M., von Feilitzsch, F., Felde, J., Fernandes, S. M., Fischer, V., Franco, D., Franke, M., Furuta, H., Gil-Botella, I., Giot, L., G��ger-Neff, M., Gomez, H., Gonzalez, L. F. G., Goodenough, L., Goodman, M. C., Haag, N., Hara, T., Haser, J., Hellwig, D., Hofmann, M., Horton-Smith, G. A., Hourlier, A., Ishitsuka, M., Jochum, J., Jollet, C., Kaether, F., Kalousis, L. N., Kamyshkov, Y., Kaneda, M., Kaplan, D. M., Kawasaki, T., Kemp, E., de Kerret, H., Kryn, D., Kuze, M., Lachenmaier, T., Lane, C. E., Lasserre, T., Letourneau, A., Lhuillier, D., Lima, H. P., Lindner, M., L��pez-Casta��o, J. M., LoSecco, J. M., Lubsandorzhiev, B., Lucht, S., Maeda, J., Mariani, C., Maricic, J., Martino, J., Matsubara, T., Mention, G., Meregaglia, A., Miletic, T., Milincic, R., Minotti, A., Nagasaka, Y., Navas-Nicol��s, D., Novella, P., Oberauer, L., Obolensky, M., Onillon, A., Osborn, A., Palomares, C., Pepe, I. M., Perasso, S., Porta, A., Pronost, G., Reichenbacher, J., Reinhold, B., R��hling, M., Roncin, R., Rybolt, B., Sakamoto, Y., Santorelli, R., Schilithz, A. C., Sch��nert, S., Schoppmann, S., Shaevitz, M. H., Sharankova, R., Shrestha, D., Sibille, V., Sinev, V., Skorokhvatov, M., Smith, E., Soiron, M., Spitz, J., Stahl, A., Stancu, I., Stokes, L. F. F., Strait, M., Suekane, F., Sukhotin, S., Sumiyoshi, T., Sun, Y., Svoboda, R., Terao, K., Tonazzo, A., Thi, H. H. Trinh, Valdiviesso, G., Vassilopoulos, N., Veyssiere, C., Vivier, M., Wagner, S., Walsh, N., Watanabe, H., Wiebusch, C., Wurm, M., Yang, G., Yermia, F., and Zimmer, V.

Subjects
High Energy Physics - Experiment (hep-ex), FOS: Physical sciences, High Energy Physics::Experiment, Instrumentation and Detectors (physics.ins-det)
Abstract

The Double Chooz collaboration presents a measurement of the neutrino mixing angle $��_{13}$ using reactor $\overline��_{e}$ observed via the inverse beta decay reaction in which the neutron is captured on hydrogen. This measurement is based on 462.72 live days data, approximately twice as much data as in the previous such analysis, collected with a detector positioned at an average distance of 1050m from two reactor cores. Several novel techniques have been developed to achieve significant reductions of the backgrounds and systematic uncertainties. Accidental coincidences, the dominant background in this analysis, are suppressed by more than an order of magnitude with respect to our previous publication by a multi-variate analysis. These improvements demonstrate the capability of precise measurement of reactor $\overline��_{e}$ without gadolinium loading. Spectral distortions from the $\overline��_{e}$ reactor flux predictions previously reported with the neutron capture on gadolinium events are confirmed in the independent data sample presented here. A value of $\sin^{2}2��_{13} = 0.095^{+0.038}_{-0.039}$(stat+syst) is obtained from a fit to the observed event rate as a function of the reactor power, a method insensitive to the energy spectrum shape. A simultaneous fit of the hydrogen capture events and of the gadolinium capture events yields a measurement of $\sin^{2}2��_{13} = 0.088\pm0.033$(stat+syst).

Published
2015
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34. Scintillating bolometers based on ZnMoO$_4$ and Zn$^{100}$MoO$_4$ crystals to search for 0$��$2$��$ decay of $^{100}$Mo (LUMINEU project): first tests at the Modane Underground Laboratory

Author

Poda, D. V., Armengaud, E., Arnaud, Q., Augier, C., Beno��t, A., Berg��, L., Boiko, R. S., Bergmann, T., Bl��mer, J., Broniatowski, A., Brudanin, V., Camus, P., Cazes, A., Censier, B., Chapellier, M., Charlieux, F., Chernyak, D. M., Coron, N., Coulter, P., Cox, G. A., Danevich, F. A., de Boissi��re, T., Decourt, R., De Jesus, M., Devoyon, L., Drillien, A. -A., Dumoulin, L., Eitel, K., Enss, C., Filosofov, D., Fleischmann, A., Fourches, N., Gascon, J., Gastaldo, L., Gerbier, G., Giuliani, A., Gros, M., Hehn, L., Henry, S., Herv��, S., Heuermann, G., Humbert, V., Ivanov, I. M., Juillard, A., K��f��lian, C., Kleifges, M., Kluck, H., Kobychev, V. V., Koskas, F., Kozlov, V., Kraus, H., Kudryavtsev, V. A., Sueur, H. Le, Loidl, M., Magnier, P., Makarov, E. P., Mancuso, M., de Marcillac, P., Marnieros, S., Marrache-Kikuchi, C., Menshikov, A., Nasonov, S. G., Navick, X-F., Nones, C., Olivieri, E., Pari, P., Paul, B., Penichot, Y., Pessina, G., Piro, M. C., Plantevin, O., Redon, T., Robinson, M., Rodrigues, M., Rozov, S., Sanglard, V., Schmidt, B., Shlegel, V. N., Siebenborn, B., Strazzer, O., Tcherniakhovski, D., Tenconi, M., Torres, L., Tretyak, V. I., Vagneron, L., Vasiliev, Ya. V., Velazquez, M., Viraphong, O., Walker, R. J., Weber, M., Yakushev, E., Zhang, X., and Zhdankov, V. N.

Subjects
FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), Nuclear Experiment (nucl-ex)
Abstract

The technology of scintillating bolometers based on zinc molybdate (ZnMoO$_4$) crystals is under development within the LUMINEU project to search for 0$��$2$��$ decay of $^{100}$Mo with the goal to set the basis for large scale experiments capable to explore the inverted hierarchy region of the neutrino mass pattern. Advanced ZnMoO$_4$ crystal scintillators with mass of $\sim$~0.3 kg were developed and Zn$^{100}$MoO$_4$ crystal from enriched $^{100}$Mo was produced for the first time by using the low-thermal-gradient Czochralski technique. One ZnMoO$_4$ scintillator and two samples (59 g and 63 g) cut from the enriched boule were tested aboveground at milli-Kelvin temperature as scintillating bolometers showing a high detection performance. The first results of the low background measurements with three ZnMoO$_4$ and two enriched detectors installed in the EDELWEISS set-up at the Modane Underground Laboratory (France) are presented., 7 pages, 5 figures, Contribution to the proceedings of the 37th International Conference on High Energy Physics (ICHEP 2014), Valencia, Spain, 2-9 July 2014

Published
2015
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35. Chronic hepatitis B in Italy: New features of an old disease - Approaching the universal prevalence of hepatitis B e antigen-negative cases and the eradication of hepatitis D infection

Author

Sagnelli, Evangelista, Stroffolini, Tommaso, Mele, Alfonso, Imparato, Michele, Almasio, Piero L., Traverso, A., Arrigoni, A., Torchio, M., Garbagnoli, P., Del Mastro, B., Romano, P., Vanni, R., Brusita, D., Meucci, P., Cassola, G., Borzio, M., Bellobuono, A., De Bona, A., Re, T., Del Poggio, P., Baisini, O., Colombo, A., Attolini, C., Sacchini, D., Minoli, L., Gazzaniga, V., Segato, S., Oriolo, M., Parlotto, A., Ghersetti, M., Capra, F., Muratori, R., Sama, C., Boccia, S., Verdianelli, G., Praticò, A., Grandi, M., Ventura, E., Cantoni, F., Vincenti, A., Nerli Alessandro, A., Galeazzi, L., Solinas, A., Paroli, M., De Sanctis, G. M., Sereno, S., Clementi, C., Visco Comandino, U., Gallo, A. I., Festi, D., Sabusco, G., Coppola, N., Scolastico, C., Onofrio, M., Filippini, P., Morisco, F., Liberti, A., Borgia, G., Scarpellino, F., Persico, M., Sagnelli, C., Coppola, C., Caserta, L., Elia, A., De Vita, G., Lanzotti, A., Pizzolante, L., Messina, V., Fiore, G., Agostinacchio, E., Santantonio, T., Mazzola, M., Vinelli, F., Campagna, A., Cataldini, S., Monelli, I., Lascaro, M., Polimeri, N., Frugiuele, P., Ferraro, M., Prestileo, T., Alessandri, A., Russello, M., Bellissima, P., Orifici, G., Pisani, G., Angioini, S., Lai, M., Spanneda, M., Sagnelli, Evangelista, Stroffolini, Tommaso, Mele, Alfonso, Imparato, Michele, Almasio, Piero L., Traverso, A., Arrigoni, A., Torchio, M., Garbagnoli, P., Del Mastro, B., Romano, P., Vanni, R., Brusita, D., Meucci, P., Cassola, G., Borzio, M., Bellobuono, A., De Bona, A., Re, T., Del Poggio, P., Baisini, O., Colombo, A., Attolini, C., Sacchini, D., Minoli, L., Gazzaniga, V., Segato, S., Oriolo, M., Parlotto, A., Ghersetti, M., Capra, F., Muratori, R., Sama, C., Boccia, S., Verdianelli, G., Praticò, A., Grandi, M., Ventura, E., Cantoni, F., Vincenti, A., Nerli Alessandro, A., Galeazzi, L., Solinas, A., Paroli, M., De Sanctis, G.M., Sereno, S., Clementi, C., Visco Comandino, U., Gallo, A.I., Festi, D., Sabusco, G., Coppola, N., Scolastico, C., Onofrio, M., Filippini, P., Morisco, F., Liberti, A., Borgia, G., Scarpellino, F., Persico, M., Sagnelli, C., Coppola, C., Caserta, L., Elia, A., De Vita, G., Lanzotti, A., Pizzolante, L., Messina, V., Fiore, G., Agostinacchio, E., Santantonio, T., Mazzola, M., Vinelli, F., Campagna, A., Cataldini, S., Monelli, I., Lascaro, M., Polimeri, N., Frugiuele, P., Ferraro, M., Prestileo, T., Alessandri, A., Russello, M., Bellissima, P., Orifici, G., Pisani, G., Angioini, S., Lai, M., and Spanneda, M.

Subjects
Liver Cirrhosis, Adult, Male, Microbiology (medical), medicine.medical_specialty, Cirrhosis, Adolescent, Hepatitis D, Chronic, Hepatitis C virus, Hepacivirus, Liver Cirrhosi, medicine.disease_cause, Gastroenterology, Virus, Flaviviridae, Hepatitis B, Chronic, Seroepidemiologic Studies, Internal medicine, medicine, Humans, Hepatitis B e Antigens, Aged, Aged, 80 and over, Cross-Sectional Studie, Hepaciviru, biology, business.industry, Seroepidemiologic Studie, Hepatitis Delta Viru, Hepatitis B, Middle Aged, medicine.disease, biology.organism_classification, Hepatitis D, Virology, Alcoholism, Cross-Sectional Studies, Infectious Diseases, Italy, Disease Progression, Female, Hepatitis B e Antigen, Hepatitis D virus, Hepatitis Delta Virus, business, Human
Abstract

We evaluated 1336 hepatitis B surface antigen-positive subjects consecutively observed in 79 Italian hospitals over a 6-month period. The proportion of hepatitis B e antigen-negative cases was 86.4%, that of patients coinfected with hepatitis D virus was 9.7%, and the rate of patients coinfected with hepatitis C virus was 16.8%. Multiple logistic regression analysis showed that age >49 years, alcohol abuse, and anti-hepatitis D virus and anti-hepatitis C virus positivity were independent predictors of progression to liver cirrhosis. © 2007 by the Infectious Diseases Society of America. All rights reserved.

Published
2008

36. The importance of HCV on the burden of chronic liver disease in Italy: a multicenter prevalence study of 9,997 cases

Author

Sagnelli, Evangelista, Stroffolini, Tommaso, Mele, Alfonso, Almasio, Piero, Coppola, Nicola, Ferrigno, Luigina, Scolastico, Carlo, Onofrio, Mirella, Imparato, Michele, Filippini, Pietro, Traverso, A., Arrigoni, A., Torchio, M., Garbagnoli, P., Del Mastro, B., Romano, P., Vanni, R., Brusita, D., Meucci, P., Cassola, G., Borzio, M., Bellobuono, A., De Bona, A., Re, T., Del Poggio, P., Baisini, O., Colombo, A., Attolini, C., Sacchini, D., Minoli, L., Gazzaniga, V., Segato, S., Oriolo, M., Parlotto, A., Ghersetti, M., Capra, F., Muratori, R., Sama, C., Boccia, S., Verdianelli, G., Praticò, A., Grandi, M., Ventura, E., Cantoni, F., Vincenti, A., Nerli, A., Galeazzi, L., Solinas, A., Paroli, M., De Sanctis, G. M., Sereno, S., Clementi, C., Comandino, U. Visco, Gallo, A. I., Festi, D., Sabusco, G., Morisco, F., Liberti, A., Borgia, G., Scarpellino, F., Persico, M., Sagnelli, C., Coppola, C., Caserta, L., Elia, A., De Vita, G., Lanzotti, A., Pizzolante, L., Messina, V., Fiore, G., Agostinacchio, E., Santantonio, T., Mazzola, M., Vinelli, F., Campagna, A., Cataldini, S., Monelli, I., Lascaro, M., Polimeri, N., Furgiuele, P. L., Ferraro, M., Prestileo, T., Alessandri, A., Russello, M., Bellissima, P., Orifici, G., Pisani, G., Angioni, S., Lai, M., Spanneda, M., SAGNELLI E, STROFFOLINI T, MELE A, ALMASIO PL, COPPOLA N, FERRIGNO L, SCOLASTICO C, ONOFRIO M, IMPARATO M, FILIPPINI P, Sagnelli, Evangelista, Stroffolini, Tommaso, Mele, Alfonso, Almasio, Piero, Coppola, Nicola, Ferrigno, Luigina, Scolastico, Carlo, Onofrio, Mirella, Imparato, Michele, Filippini, Pietro, Traverso, A., Arrigoni, A., Torchio, M., Garbagnoli, P., Del Mastro, B., Romano, P., Vanni, R., Brusita, D., Meucci, P., Cassola, G., Borzio, M., Bellobuono, A., De Bona, A., Re, T., Del Poggio, P., Baisini, O., Colombo, A., Attolini, C., Sacchini, D., Minoli, L., Gazzaniga, V., Segato, S., Oriolo, M., Parlotto, A., Ghersetti, M., Capra, F., Muratori, R., Sama, C., Boccia, S., Verdianelli, G., Praticò, A., Grandi, M., Ventura, E., Cantoni, F., Vincenti, A., Nerli, A., Galeazzi, L., Solinas, A., Paroli, M., De Sanctis, G.M., Sereno, S., Clementi, C., Comandino, U. Visco, Gallo, A.I., Festi, D., Sabusco, G., Morisco, F., Liberti, A., Borgia, G., Scarpellino, F., Persico, M., Sagnelli, C., Coppola, C., Caserta, L., Elia, A., De Vita, G., Lanzotti, A., Pizzolante, L., Messina, V., Fiore, G., Agostinacchio, E., Santantonio, T., Mazzola, M., Vinelli, F., Campagna, A., Cataldini, S., Monelli, I., Lascaro, M., Polimeri, N., Furgiuele, P.L., Ferraro, M., Prestileo, T., Alessandri, A., Russello, M., Bellissima, P., Orifici, G., Pisani, G., Angioni, S., Lai, M., and Spanneda, M.

Subjects
Adult, Liver Cirrhosis, Male, Hepatitis B virus, HBsAg, Carcinoma, Hepatocellular, Cirrhosis, alcohol abuse, Hepatitis C virus, Hepacivirus, Chronic liver disease, medicine.disease_cause, Risk Factors, Virology, Prevalence, medicine, HBV, Humans, Aged, business.industry, Incidence, Liver Diseases, Liver Neoplasms, Hepatitis C, Middle Aged, Hepatitis B, medicine.disease, Alcoholism, Infectious Diseases, Italy, Hepatocellular carcinoma, Chronic Disease, HCV, Female, Viral hepatitis, business
Abstract

Knowledge of the current epidemiology of chronic liver disease in Italy is mostly obsolete and fragmentary for the lack of up-to-date consistent data. In 2001, a 6-month prevalence study was undertaken in 79 hospitals to assess the characteristics of chronic liver disease in Italy. Both prevalent and incident cases were enrolled. A total of 9,997 patients were recruited, of whom 939 (9.4%) had normal liver biochemistry, 6,210 (62.1%) had chronic hepatitis, 1,940 (19.4%) had liver cirrhosis, and 341 (3.4%) had hepatocellular carcinoma (HCC). In 567 patients (5.7%) the diagnosis was not established. Hepatitis C virus (HCV) was found in 69.9% of the patients and was the only etiological factor in 56.3% of all the patients. Hepatitis B surface antigen (HBsAg) was present in the serum of 13.4% of the cases (in 10% it was the only etiological factor). A history of alcohol abuse was found in 23% of the cases (9.4% without viral infection). The prevalence of HCV-related cases was significantly lower in incident than in prevalent cases (44.9% vs. 59.9%, P < 0.0001), while the proportion of patients with alcohol abuse was much higher in incident than in prevalent cases (18.1% vs. 6.6%, P < 0.0001). These findings indicate that nearly one quarter of patients with chronic liver diseases in Italy have a severe disease such as liver cirrhosis and HCC represents a not negligible burden for the national health system. Hepatitis B fell in importance as an etiological factor. Hepatitis C is the important pathogenic factor for chronic liver disease in Italy. However, a comparison between the prevalent and incident cases suggests that in future HCV infection will also play a progressively decreasing role, in part as a consequence of treatment. © 2005 Wiley-Liss, Inc.

Published
2005

37. The aetiology of chronic hepatitis in Italy: results from a multicentre national study

Author

Stroffolini, T., Sagnelli, E., Mele, A., Craxi, A., Almasio, P., Traverso, A., Arrigoni, A., Torchio, M., Garbagnoli, P., Del Mastro, B., Romano, P., Vanni, R., Brusita, D., Meucci, P., Cassola, G., Borzio, M., Bellobuono, A., De Bona, A., Re, T., Del Poggio, P., Baisini, O., Colombo, A., Attolini, C., Daria, Sacchini, Minoli, L., Gazzaniga, V., Segato, S., Oriolo, M., Parlotto, A., Ghersetti, M., Capra, F., Muratori, R., Sama, C., Boccia, S., Verdianelli, G., Pratico, A., Grandi, M., Ventura, E., Cantoni, F., Vincenti, A., Nerli Alessandro, A., Galeazzi, L., Solinas, A., Paroli, Marino, De Sanctis, G. M., Sereno, S., Clementi, C., Visco Comandino, U., Gallo, A. I., Festi, D., Sabusco, G., Coppola, N., Scolastico, C., Onofrio, M., Imparato, M., Filippini, P., Morisco, F., Liberti, A., Borgia, G., Scarpellino, F., Persico, M., Sagnelli, C., Coppola, C., Caserta, L., Elia, A., De Vita, G., Lanzotti, A., Pizzolante, L., Messina, V., Fiore, G., Agostinacchio, E., Santantonio, T., Mazzola, M., Vinelli, F., Campagna, A., Cataldini, S., Monelli, I., Lascaro, M., Polimeri, N., Frigiuele, P., Ferraro, M., Prestileo, T., Alessandri, A., Russello Maurizio, M., Bellissima, P., Orifici, G., Pisani, G., Angioini, S., Lai, M., Spanneda, M., Stroffolini, T, Sagnelli, E, Mele, A, Crax, A, Almasio, P, Coppola, Nicola, Italian Hospitals Collaborating, Group, Filippini, Pietro, Sagnelli, Caterina, STROFFOLINI T, SAGNELLI E, MELE A, CRAXI A, ALMASIO PL, ITALIAN HOSPITALS, COLLABORATING GROUP, Stroffolini, T., Sagnelli, E., Mele, A., Craxì, A., Almasio, P., Traverso, A., Arrigoni, A., Torchio, M., Garbagnoli, P., Del Mastro, B., Romano, P., Vanni, R., Brusita, D., Meucci, P., Cassola, G., Borzio, M., Bellobuono, A., De Bona, A., Re, T., Del Poggio, P., Baisini, O., Colombo, A., Attolini, C., Daria, S., Minoli, L., Gazzaniga, V., Segato, S., Oriolo, M., Parlotto, A., Ghersetti, M., Capra, F., Muratori, R., Sama, C., Boccia, S., Verdianelli, G., Praticò, A., Grandi, M., Ventura, E., Cantoni, F., Vincenti, A., Nerli Alessandro, A., Galeazzi, L., Solinas, A., Paroli, M., De Sanctis, G.M., Sereno, S., Clementi, C., Visco Comandino, U., Gallo, A.I., Festi, D., Sabusco, G., Coppola, N., Scolastico, C., Onofrio, M., Imparato, M., Filippini, P., Morisco, F., Liberti, A., Borgia, G., Scarpellino, F., Persico, M., Sagnelli, C., Coppola, C., Caserta, L., Elia, A., De Vita, G., Lanzotti, A., Pizzolante, L., Messina, V., Fiore, G., Agostinacchio, E., Santantonio, T., Mazzola, M., Vinelli, F., Campagna, A., Cataldini, S., Monelli, I., Lascaro, M., Polimeri, N., Frigiuele, P., Ferraro, M., Prestileo, T., Alessandri, A., Russello Maurizio, M., Bellissima, P., Orifici, G., Pisani, G., Angioini, S., Lai, M., and Spanneda, M.

Subjects
Adult, Male, medicine.medical_specialty, HBsAg, Hepatitis D, Chronic, Epidemiology, Hepatitis C virus, Autoimmune hepatitis, medicine.disease_cause, Autoimmune Diseases, Hepatitis B, Chronic, Internal medicine, medicine, Prevalence, Humans, Hepatitis B virus, Hepatology, business.industry, Gastroenterology, Hepatitis C, Hepatitis B, Hepatitis C, Chronic, Middle Aged, medicine.disease, Hepatitis D, HBeAg, Italy, Immunology, Chronic hepatiti, Female, chronic hepatitis, epidemiology, italy, business
Abstract

Background: No recent national-level data on the aetiology of chronic hepatitis are available in Italy. Aim: To evaluate the current aetiology of chronic hepatitis in Italy. Patients: A total of 6210 chronic hepatitis patients (both prevalence and incident cases) consecutively admitted to 79 hospitals located throughout Italy were enrolled over a 6-month period in 2001. The hospitals were randomly selected through systematic cluster sampling. Results: The main agent associated with chronic hepatitis was hepatitis C virus, which was found in 76.5% of the patients (in 62.6% it was the only aetiologic factor). Hepatitis B surface antigen was present in the serum of 12.2% of the cases (in 9.2% it was the only aetiologic factor). Hepatitis B e antigen and hepatitis Delta were detected in 16.6% and 7.0%, respectively, of hepatitis B surface antigen-positive patients. A history of alcohol abuse was found in 19.2% of the cases (5.5% without viral infection). Autoimmune hepatitis and inborn metabolic disorders were extremely rare. The prevalence of hepatitis C virus-related cases was significantly lower in incident cases, compared to prevalent cases (55.1% versus 65.0%; p < 0.01). The mean alanine aminotransferase level was significantly higher in hepatitis B surface antigen-positive patients, compared to hepatitis B surface antigen-negative patients. The histology was less severe in non-viral-related cases. Conclusions: Hepatitis C virus is the most important pathogenic factor for chronic hepatitis in Italy; however, the comparison between prevalent and incident cases suggests that this infection will play a less important role in the future. A comparison with previous reports shows that both hepatitis B virus-related and hepatitis Delta virus-related cases are decreasing. © 2004 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

Published
2004

38. Pegylated interferon α plus ribavirin for the treatment of chronic hepatitis C: A multicentre independent study supported by the Italian Drug Agency

Author

Rosina, Floriano, Tosti, Maria Elena, Borghesio, Elisabetta, Masocco, Maria, Mele, Alfonso, Coppola, Carmine, Milella, Michele, Borgia, Guglielmo, Andreone, Pietro, Koch, Maurizio, Zignego, Anna Linda, Romano, Mario, Carrara, Maurizio, Almasio, Piero Luigi, Azzola, Emilio, Nardone, Gerardo, Benedetti, Antonio, Carosi, Giampiero, Mazzotta, Francesco, Sagnelli, Evangelista, Rizzetto, Mario, Mascolo, M. C., Cursaro, C., Scuteri, A., Crespi, C., Gianstefani, A., Ranieri, J., Monti, M., Corti, G., Blanc, P. L., Baragli, F., Bellentani, S., Gasbarrini, A., Pompili, M., Mecenate, F., Picardi, A., Vespasiani, U., Nosotti, Null, Null, A. Picardi, Ricci, G. L., Paffetti, A., Mastropietro, C., Moretti, A., Spagnolo, A. L., Puoti, C., Bellis, L., Regazzetti, A., Maffezzini, E., Pietrangelo, A., Abbati, G., Borghi, A., Sardini, C., Raimondo, G., Scribano, L., Martines, D., Svegliati Baroni, G., Faraci, G., Schi anchi, S., Fornaciari, G., Massari, M., Fabris, P., Bertin, T., Salvagnini, M., Madonia, S., Calì, A., Civitavecchia, G., Pirisi, M., Smirne, C., Andreoletti, M., Morisco, F., Caporaso, N., Gentile, I., Brancaccio, G., Gaeta, G. B., Liberti, A., Iannece, M. D., Rocco, A., Federico, A., Loguercio, C., Riegler, G., Esposito, P., Fargion, S., Fatta, E., Masutti, F., Bonaventura, M. E., Autolitano, A., Russello, M., Bellia, A., Toniutto, P., Bitetto, D., Pasulo, L., Lucà, M. G., Grattagliano, I., Palasciano, G., Romagno, D., Giannelli, G., Napoli, N., Plattella, M. S., Cassano, P., Gobbo, G., Monti, V., Raspanti, A., Cuccorese, Null, Colombo, A. E., Mandelli, G., Spinzi, G. C., Floridia, Null, Messina, V., Bonfante, S., Bellissima, P., Toti, M., Vecchiet, J., Falasca, K., Portelli, V., Stefano, G. De, Pietromatera, G., Viganò, P., Re, T., Andreoni, M., Null, G. Raineri, Grossi, P. A., Caputo, S., Cassola, G., Feasi, M., Biagio, A. Di, Nicolini, LAURA AMBRA, Giannini, EDOARDO GIOVANNI, Corbo, M., Foti, G., Kunkar, A., Caterini, L., Migliorini, D., Chiodera, A., Calleri, G., Spezia, C., Framarin, L., Null, M. Berrutti, Ciancio, A., Baiguera, C., Puoti, M., Vento, S., Contini, C., Boccia, S., Casiraghi, M. A., Simone, L., Tacconi, D., Caremani, M., Almi, P., Chimenti, M., Cosco, Null, Messeri, D., Esperti, F. C., Lomonaco, L., Pazzi, P., Fornari, F., Comparato, G., Casetti, T., Foschi, F. G., Samori, A., Ferretti, E., Marin, R., Campo, N., Testa, R., Rizzo, S., Rosina, F, Tosti, ME, Borghesio, E, Masocco, M, Mele, A, Coppola, C, Milella, M, Borgia, G, Andreone, P, Koch, M, Zignego, AL, Romano, M, Carrara, M, Almasio, PL, Azzola, E, Nardone, G, Benedetti, A, Carosi, G, Mazzotta, F, Sagnelli, E, Rizzetto, M, Rosina, F., Tosti, M. E., Borghesio, E., Masocco, M., Mele, A., Coppola, C., Milella, M., Borgia, Guglielmo, Andreone, P., Koch, M., Zignego, A. L., Romano, M., Carrara, M., Almasio, P. L., Azzola, E., Nardone, GERARDO ANTONIO PIO, Benedetti, A., Carosi, G., Mazzotta, F., Sagnelli, E., Rizzetto, M., Aifa, Aisf, Simit, Aigo, Sige, Gentile, Ivan, Morisco, Filomena, Et, Al, Floriano Rosina, Maria Elena Tosti, Elisabetta Borghesio, Maria Masocco, Alfonso Mele, Carmine Coppola, Michele Milella, Guglielmo Borgia, Pietro Andreone, Maurizio Koch, Anna Linda Zignego, Mario Romano, Maurizio Carrara, Piero Luigi Almasio, Emilio Azzola, Gerardo Nardone, Antonio Benedetti, Giampiero Carosi, Francesco Mazzotta, Evangelista Sagnelli, and Mario Rizzetto

Subjects
Registrie, Male, Cirrhosis, medicine.disease_cause, Polyethylene Glycol, Gastroenterology, Polyethylene Glycols, chemistry.chemical_compound, Hepatitis Viruses, Hepatitis Viruse, Prospective Studies, Viral, Registries, Chronic, Prospective cohort study, Drug Carrier, Drug Carriers, Settore MED/12 - Gastroenterologia, Medicine (all), Recombinant Protein, Middle Aged, Hepatitis C, Recombinant Proteins, Treatment Outcome, Italy, Combination, RNA, Viral, Population study, Drug Therapy, Combination, Female, Human, medicine.medical_specialty, Genotype, Hepatitis C virus, Alpha interferon, Ribavirin, Sustained virological response (SVR), Treatment, Antiviral Agents, Follow-Up Studie, Hepatology, Drug Therapy, Internal medicine, medicine, Humans, Antiviral Agent, business.industry, Interferon-alpha, HCV therapy, Hepatitis C, Chronic, medicine.disease, Clinical trial, Prospective Studie, chemistry, Immunology, RNA, Follow-Up Studies, business
Abstract

a b s t r a c t Background: Data on the efficacy of Peg-interferon/ribavirin therapy for chronic hepatitis C are mostly derived from treatment of selected patients enrolled in clinical trials. This study aimed to assess the effectiveness of Peg-interferon/ribavirin therapy in “real world” chronic hepatitis C patients in Italy. Methods: Independent observational multicentre study including consecutive patients receiving Peginterferon/ribavirin in the 18 months before (retrospective phase) and after (prospective phase) the start of the study. Results: 4176 patients were eligible. The final study population consisted of 2051 patients in the retrospective and 2073 in the prospective phase. Sustained virological response was achieved by 1036 patients (50.5%) during the retrospective phase: 325 were genotypes 1/4 (34.1%) and 684 were genotypes 2/3 (67.2%) and by 800 patients (38.6%) during the prospective phase: 300 were genotypes 1/4 (28.4%) and 473 were genotypes 2/3 (51.5%). During multivariate analysis genotypes 2/3 were significantly associated with higher sustained virological response rates; cirrhosis and -glutamil-transpeptidase >2 times the normal limit were associated with poorer response. Conclusions: The response to Peg-interferon/ribavirin therapy in “real world” clinical practice is distinctly lower than in registration trials. The difference in response rates was more pronounced among easy-totreat than among difficult-to-treat hepatitis C virus genotypes.

Published
2014

39. Measurement of the neutrino velocity with the OPERA detector in the CNGS beam using the 2012 dedicated data

Author

The OPERA Collaboration, Adam, T., Agafonova, N., Aleksandrov, A., Anokhina, A., Aoki, S., Ariga, A., Ariga, T., Autiero, D., Badertscher, A., Dhahbi, A. Ben, Beretta, M., Bertolin, A., Bozza, C., Brugi��re, T., Brugnera, R., Brunet, F., Brunetti, G., Buettner, B., Buontempo, S., Carlus, B., Cavanna, F., Cazes, A., Chaussard, L., Chernyavsky, M., Chiarella, V., Chukanov, A., D'Ambrosio, N., De Lellis, G., De Serio, M., Sanchez, P. del Amo, Di Crescenzo, A., Di Ferdinando, D., Di Marco, N., Dmitrievsky, S., Dracos, M., Duchesneau, D., Dusini, S., Dzhatdoev, T., Ebert, J., Ereditato, A., Esposito, L. S., Favier, J., Felici, G., Ferber, T., Fini, R. A., Fukuda, T., Garfagnini, A., Giacomelli, G., Girerd, C., Goellnitz, C., Goldberg, J., Golubkov, D., Gornushkin, Y., Grella, G., Grianti, F., Guerin, C., Guler, A. M., Gustavino, C., Hagner, C., Hamada, K., Hara, T., Hierholzer, M., Hollnagel, A., Ishida, H., Ishiguro, K., Jakovcic, K., Jollet, C., Kamiscioglu, C., Kamiscioglu, M., Kawada, J., Kim, J. H., Kim, S. H., Kimura, M., Kitagawa, N., Klicek, B., Kodama, K., Komatsu, M., Kose, U., Kreslo, I., Lauria, A., Lazzaro, C., Lenkeit, J., Ljubicic, A., Longhin, A., Mancini-Terracciano, C., Malgin, A., Mandrioli, G., Marteau, J., Matsuo, T., Matveev, V., Mauri, N., Medinaceli, E., Meregaglia, A., Migliozzi, P., Mikado, S., Monacelli, P., Montesi, M. C., Morishima, K., Moser, U., Muciaccia, M. T., Nakamura, M., Nakano, T., Nakatsuka, Y., Naumov, D., Nikitina, V., Ogawa, S., Olchevsky, A., Ozaki, K., Palamara, O., Paoloni, A., Park, B. D., Park, I. G., Pastore, A., Patrizii, L., Pennacchio, E., Pessard, H., Pistillo, C., Podgrudkov, D., Polukhina, N., Pozzato, M., Pretzl, K., Pupilli, F., Rescigno, R., Roda, M., Roganova, T., Rokujo, H., Rosa, G., Rostovtseva, I., Rubbia, A., Russo, A., Ryazhskaya, O., Sato, O., Sato, Y., Schembri, A., Schmidt-Parzefall, W., Schuler, J., Shakiryanova, I., Sheshukov, A., Shibuya, H., Shoziyoev, G., Simone, S., Sioli, M., Sirignano, C., Sirri, G., Song, J. S., Spinetti, M., Stanco, L., Starkov, N., Stellacci, S. M., Stipcevic, M., Strauss, T., Takahashi, S., Tenti, M., Terranova, F., Tioukov, V., Tolun, P., Tufanli, S., Vilain, P., Vladimirov, M., Votano, L., Vuilleumier, J. L., Wilquet, G., Wonsak, B., Wurtz, J., Yoon, C. S., Yoshida, J., Zaitsev, Y., Zemskova, S., Zghiche, A., Zimmermann, R., T. Adam, N. Agafonova, A. Aleksandrov, A. Anokhina, S. Aoki, A. Ariga, T. Ariga, D. Autiero, A. Badertscher, A. Ben Dhahbi, M. Beretta, A. Bertolin, C. Bozza, T. Brugière, R. Brugnera, F. Brunet, G. Brunetti, B. Buettner, S. Buontempo, B. Carlu, F. Cavanna, A. Caze, L. Chaussard, M. Chernyavsky, V. Chiarella, A. Chukanov, N. D’Ambrosio, G. Lelli, M. Serio, P. Amo Sanchez, A. Crescenzo, D. Ferdinando, N. Marco, S. Dmitrievsky, M. Draco, D. Duchesneau, S. Dusini, T. Dzhatdoev, J. Ebert, A. Ereditato, L. S. Esposito, J. Favier, G. Felici, T. Ferber, R. A. Fini, T. Fukuda, A. Garfagnini, G. Giacomelli, C. Girerd, C. Goellnitz, J. Goldberg, D. Golubkov, Y. Gornushkin, G. Grella, F. Grianti, C. Guerin, A. M. Guler, C. Gustavino, C. Hagner, K. Hamada, T. Hara, M. Hierholzer, A. Hollnagel, H. Ishida, K. Ishiguro, K. Jakovcic, C. Jollet, C. Kamiscioglu, M. Kamiscioglu, J. Kawada, J. H. Kim, S. H. Kim, M. Kimura, N. Kitagawa, B. Klicek, K. Kodama, M. Komatsu, U. Kose, I. Kreslo, A. Lauria, C. Lazzaro, J. Lenkeit, A. Ljubicic, A. Longhin, A. Malgin, C. Mancini-Terracciano, G. Mandrioli, J. Marteau, T. Matsuo, V. Matveev, N. Mauri, E. Medinaceli, A. Meregaglia, P. Migliozzi, S. Mikado, P. Monacelli, M. C. Montesi, K. Morishima, U. Moser, M. T. Muciaccia, M. Nakamura, T. Nakano, Y. Nakatsuka, D. Naumov, V. Nikitina, S. Ogawa, A. Olchevsky, K. Ozaki, O. Palamara, A. Paoloni, B. D. Park, I. G. Park, A. Pastore, L. Patrizii, E. Pennacchio, H. Pessard, C. Pistillo, D. Podgrudkov, N. Polukhina, M. Pozzato, K. Pretzl, F. Pupilli, R. Rescigno, M. Roda, T. Roganova, H. Rokujo, G. Rosa, I. Rostovtseva, A. Rubbia, A. Russo, O. Ryazhskaya, O. Sato, Y. Sato, A. Schembri, W. Schmidt-Parzefall, J. Schuler, I. Shakiryanova, A. Sheshukov, H. Shibuya, G. Shoziyoev, S. Simone, M. Sioli, C. Sirignano, G. Sirri, J. S. Song, M. Spinetti, L. Stanco, N. Starkov, S. M. Stellacci, M. Stipcevic, T. Strau, S. Takahashi, M. Tenti, F. Terranova, V. Tioukov, P. Tolun, S. Tufanli, P. Vilain, M. Vladimirov, L. Votano, J.-L. Vuilleumier, G. Wilquet, B. Wonsak, J. Wurtz, C. S. Yoon, J. Yoshida, Y. Zaitsev, S. Zemskova, A. Zghiche, R. Zimmermann, Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), OPERA, DE LELLIS, Giovanni, DI CRESCENZO, Antonia, M., Draco, Lauria, Adele, Montesi, MARIA CRISTINA, Adam, T, Agafonova, N, Aleksandrov, A, Anokhina, A, Aoki, S, Ariga, A, Ariga, T, Autiero, D, Badertscher, A, Ben Dhahbi, A, Beretta, M, Bertolin, A, Bozza, C, Brugière, T, Brugnera, R, Brunet, F, Brunetti, G, Buettner, B, Buontempo, S, Carlus, B, Cavanna, F, Cazes, A, Chaussard, L, Chernyavsky, M, Chiarella, V, Chukanov, A, D’Ambrosio, N, De Lellis, G, De Serio, M, del Amo Sanchez, P, Di Crescenzo, A, Di Ferdinando, D, Di Marco, N, Dmitrievsky, S, Dracos, M, Duchesneau, D, Dusini, S, Dzhatdoev, T, Ebert, J, Ereditato, A, Esposito, L, Favier, J, Felici, G, Ferber, T, Fini, R, Fukuda, T, Garfagnini, A, Giacomelli, G, Girerd, C, Goellnitz, C, Goldberg, J, Golubkov, D, Gornushkin, Y, Grella, G, Grianti, F, Guerin, C, Guler, A, Gustavino, C, Hagner, C, Hamada, K, Hara, T, Hierholzer, M, Hollnagel, A, Ishida, H, Ishiguro, K, Jakovcic, K, Jollet, C, Kamiscioglu, C, Kamiscioglu, M, Kawada, J, Kim, J, Kim, S, Kimura, M, Kitagawa, N, Klicek, B, Kodama, K, Komatsu, M, Kose, U, Kreslo, I, Lauria, A, Lazzaro, C, Lenkeit, J, Ljubicic, A, Longhin, A, Malgin, A, Mancini Terracciano, C, Mandrioli, G, Marteau, J, Matsuo, T, Matveev, V, Mauri, N, Medinaceli, E, Meregaglia, A, Migliozzi, P, Mikado, S, Monacelli, P, Montesi, M, Morishima, K, Moser, U, Muciaccia, M, Nakamura, M, Nakano, T, Nakatsuka, Y, Naumov, D, Nikitina, V, Ogawa, S, Olchevsky, A, Ozaki, K, Palamara, O, Paoloni, A, Park, B, Park, I, Pastore, A, Patrizii, L, Pennacchio, E, Pessard, H, Pistillo, C, Podgrudkov, D, Polukhina, N, Pozzato, M, Pretzl, K, Pupilli, F, Rescigno, R, Roda, M, Roganova, T, Rokujo, H, Rosa, G, Rostovtseva, I, Rubbia, A, Russo, A, Ryazhskaya, O, Sato, O, Sato, Y, Schembri, A, Schmidt Parzefall, W, Schuler, J, Shakiryanova, I, Sheshukov, A, Shibuya, H, Shoziyoev, G, Simone, S, Sioli, M, Sirignano, C, Sirri, G, Song, J, Spinetti, M, Stanco, L, Starkov, N, Stellacci, S, Stipcevic, M, Strauss, T, Takahashi, S, Tenti, M, Terranova, F, Tioukov, V, Tolun, P, Tufanli, S, Vilain, P, Vladimirov, M, Votano, L, Vuilleumier, J, Wilquet, G, Wonsak, B, Wurtz, J, Yoon, C, Yoshida, J, Zaitsev, Y, Zemskova, S, Zghiche, A, and Zimmermann, R

Subjects
Nuclear and High Energy Physics, Particle physics, Physics - Instrumentation and Detectors, Proton, 530 Physics, Physics::Instrumentation and Detectors, GPS, FOS: Physical sciences, 01 natural sciences, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Muon neutrino, neutrino detectors and telescopes, oscillation, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, Nuclear Experiment, Physics, Neutrino Detectors and Telescopes, Large Hadron Collider, 010308 nuclear & particles physics, Detector, RELATIVITÀ RISTRETTA, speed, Instrumentation and Detectors (physics.ins-det), Oscillation, oscillations, Physique des particules élémentaires, Speed of light, High Energy Physics::Experiment, RIVELATORI DI PARTICELLE ELEMENTARI, Neutrino, NEUTRINO, Beam (structure), Particle Physics - Experiment, Bar (unit)
Abstract

In spring 2012 CERN provided two weeks of a short bunch proton beam dedicated to the neutrino velocity measurement over a distance of 730 km. The OPERA neutrino experiment at the underground Gran Sasso Laboratory used an upgraded setup compared to the 2011 measurements, improving the measurement time accuracy. An independent timing system based on the Resistive Plate Chambers was exploited providing a time accuracy of ~1 ns. Neutrino and anti-neutrino contributions were separated using the information provided by the OPERA magnetic spectrometers. The new analysis profited from the precision geodesy measurements of the neutrino baseline and of the CNGS/LNGS clock synchronization. The neutrino arrival time with respect to the one computed assuming the speed of light in vacuum is found to be δt ν ≡ T OF c - T OF ν = (0.6±0.4 (stat.)±3.0 (syst.)) ns and δtν≡TOF c-TOFν = (1.7±1.4(stat.}±3.1(syst.) ns for νμ and νμ, respectively. This corresponds to a limit on the muon neutrino velocity with respect to the speed of light of -1.8 × 10-6 < (v ν - c)/c < 2.3 × 10-6 at 90% C.L. This new measurement confirms with higher accuracy the revised OPERA result. © 2013 SISSA., 0, OPERA Collaboration ;14 pp., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2012
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40. Highly multimode memory in a crystal

Author

Bonarota, M., Gou��t, J. -L. Le, and Chaneli��re, T.

Subjects
Quantum Physics, FOS: Physical sciences, Physics::Optics, Physics::Atomic Physics, Quantum Physics (quant-ph)
Abstract

We experimentally demonstrate the storage of 1060 temporal modes onto a thulium-doped crystal using an atomic frequency comb (AFC). The comb covers 0.93 GHz defining the storage bandwidth. As compared to previous AFC preparation methods (pulse sequences i.e. amplitude modulation), we only use frequency modulation to produce the desired optical pumping spectrum. To ensure an accurate spectrally selective optical pumping, the frequency modulated laser is self-locked on the atomic comb. Our approach is general and should be applicable to a wide range of rare-earth doped material in the context of multimode quantum memory.

Published
2010

42. Treatment of chronic hepatitis B: recommendations from an Italian workshop

Author

Carosi, G., Rizzetto, M., Andreone, P., Angelico, M., Ascione, A., Caporaso, N., Fagiuolim, S., Fattovich, G., Mondelli, M., Niro, G. A., Pontisso, P., Bonino, F., Perno, C. F., Prati, D., Andreoni, M., Angarano, G., Annicchiarico, E., Boncoraglio, R., Brustia, D., Calabrese, N., Carlotto, A., Cavalletto, L., Cavina, M., Chessa, L., Croce, G., De Sanctis, G., Di Candilo, F., Fabris, P., Fracassetti, O., Lanza, A. G., Giuberti, T., Guazzotti, G., Iacovazzi, T., Iovinella, V., Izzi, A., Loperfido, P., Magni, C. F., Marino, N., Messina, V., Michelone, G., Morante, R., Moretti, A., Nasta, P., Nauri, L., Paffetti, A., Pasino, M., Perboni, G., Petrelli, E., Picciotto, A., Pozzi, M., Purificato, F., Re, T., Rinaldi, R., Sani, S., Santoro, R., Schioppa, O., Scotto, G., Siciliano, M., Sorbello, O., Squadrito, G., Taddei, M. T., Traversa, A., Tundo, P., Venezia, G., Vilardo, L., Zignego, A. L., Zoncada, A., and Zuin, M.

Subjects
Liver Cirrhosis, medicine.medical_specialty, Cirrhosis, Immune suppressed, Human immunodeficiency virus (HIV), HIV Infections, Disease, Antiviral therapy, medicine.disease_cause, Antiviral Agents, Immunocompromised Host, Hepatitis B, Chronic, Chronic hepatitis, Interferon, HDV, Internal medicine, Drug Resistance, Viral, HBV, medicine, Humans, Hepatitis B Antibodies, Liver histology, Hepatitis B virus, HCV, HIV, Hepatology, business.industry, Gastroenterology, Hepatitis B, medicine.disease, Hepatitis C, Hepatitis D, Italy, Immunology, business, medicine.drug
Abstract

The changing scenario of hepatitis B virus therapy has encouraged the organisation of a workshop, endorsed by three Italian scientific societies, aimed at defining the current recommendations for hepatitis B virus treatment. Liver histology and stage of disease remain fundamental for treatment decisions; interferon and nucleoside/nucleotide analogues-based therapy represent different strategies for different phases of the hepatitis B virus disease. The recommendations defined: new and lower cut-off of hepatitis B virus–DNA for eligibility to therapy according to disease stage, how to optimise the use of nucleoside/nucleotide analogues and to individualise the monitoring of response and what to do with treatment failures. Specific recommendations have also been given for cirrhosis patients, those immune suppressed and co-infected with HIV and other hepatitis viruses. © 2008 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

Published
2008

43. HCV infection is a risk factor for gallstone disease in liver cirrhosis: an Italian epidemiological survey. J Viral Hepat

Author

Stroffolini, T., Sagnelli, E., Mele, A., Cottone, C., Almasio, Pl, Traverso, ., Arrigoni, A., Torchio, M., Garbagnoli, P., Del Mastro, B., Romano, P., Vanni, R., Brusita, D., Meucci, P., Cassola, G., Borzio, M., Bellobuono, A., Bona, A., Re, T., Del Poggio, P., Baisini, O., Colombo, A., Attolini, C., Sacchini, D., Minoli, L., Gazzaniga, V., Segato, S., Oriolo, M., Parlotto, A., Ghersetti, M., Capra, F., Muratori, R., Sama, C., Boccia, S., Verdianelli, G., Praticò, A., Grandi, M., Ventura, E., Cantoni, F., Vincenti, A., Nerli Alessandro, A., Galeazzi, L., Solinas, A., Marino PAROLI, Sanctis, G. M., Sereno, S., Clementi, C., Visco Comandino, U., Gallo, A. I., Sabusco, D. G., Coppola, N., Scolastico, C., Onofrio, M., Filippini, P., Morisco, F., Liberti, A., Borgia, G., Scarpellino, F., Persico, M., Sagnelli, C., Coppola, C., Caserta, L., Elia, A., Vita, G., Lanzotti, A., Pizzolante, L., Messina, V., Fiore, G., Agostinacchio, E., Santantonio, T., Mazzola, M., Vinelli, F., Campagna, A., Cataldini, S., Monelli, I., Lascaro, M., Polimeri, N., Frugiuele, P., Ferraro, M., Prestileo, T., Alessandri, A., Russello, M., Bellissima, P., Orifici, G., Pisani, G., Angioini, S., Lai, M., and Spanneda, M.

Published
2007

44. Characteristics of HCV positive subjects referring to hospitals in Italy: a multicentre prevalence study on 6,999 cases

Author

Stroffolini, T., Sagnelli, E., Mariano, A., Craxí, A., Almasio, P., Traverso, ., Arrigoni, A., Torchio, M., Garbagnoli, P., Del Mastro, B., Romano, P., Vanni, R., Brusita, D., Meucci, P., Cassola, G., Borzio, M., Bellobuono, A., Bona, A., Re, T., Del Poggio, P., Baisini, O., Colombo, A., Attolini, C., Sacchini, D., Minoli, L., Gazzaniga, V., Segato, S., Oriolo, M., Parlotto, A., Ghersetti, M., Capra, F., Muratori, R., Sama, C., Boccia, S., Verdianelli, G., Praticò, A., Grandi, M., Ventura, E., Cantoni, F., Vincenti, A., Nerli Alessandro, A., Galeazzi, L., Solinas, A., Marino PAROLI, Sanctis, G. M., Sereno, S., Clementi, C., Visco Comandino, U., Gallo, A. I., Sabusco, D. G., Coppola, N., Scolastico, C., Onofrio, M., Filippini, P., Morisco, F., Liberti, A., Borgia, G., Scarpellino, F., Persico, M., Sagnelli, C., Coppola, C., Caserta, L., Elia, A., Vita, G., Lanzotti, A., Pizzolante, L., Messina, V., Fiore, G., Agostinacchio, E., Santantonio, T., Mazzola, M., Vinelli, F., Campagna, A., Cataldini, S., Monelli, I., Lascaro, M., Polimeri, N., Frugiuele, P., Ferraro, M., Prestileo, T., Alessandri, Nicola, Russello, M., Bellissima, P., Orifici, G., Pisani, G., Angioini, S., Lai, M., and Spanneda, M.

Published
2006

45. Search for gravitational wave bursts in LIGO's third science run

Author

Abbott, B., Abbott, R., Adhikari, R., Agresti, J., Allen, B., Amin, R., Anderson, S., Anderson, W., Araya, M., Armandula, H., Ashley, M., Ajith, P., Aulbert, C., Babak, S., Balasubramanian, R., Ballmer, S., Barish, B., Barker, D., Barker, C., Allen, J., Bantilan, H., Barton, M., Bayer, K., Belczynski, K., Betzwieser, J., Bhawal, B., Bilenko, I., Billingsley, G., Black, E., Blackburn, K., Blackburn, L., Bland, B., Bogue, L., Bork, R., Bose, S., Brady, P., Braginsky, V., Brau, J., Brown, D., Buonanno, A., Cannon, K., Busby, D., Butler, W., Cao, J., Cadonati, L., Cagnoli, G., Camp, J., Cannizzo, J., Cardenas, L., Carter, K., Casey, M., Charlton, P., Chatterji, S., Chen, Y., Chin, D., Christensen, N., Cokelaer, T., Colacino, C., Coldwell, R., Cook, D., Corbitt, T., Coyne, D., Creighton, J., Creighton, T., Dalrymple, J., D'Ambrosio, E., Danzmann, K., Davies, G., Desai, S., DeBra, D., Dergachev, V., DeSalvo, R., Dhurandhar, S., Diaz, M., Di Credico, A., Drever, R., Dupuis, R., Ehrens, P., Etzel, T., Evans, M., Evans, T., Fairhurst, S., Garofoli, J., Gholami, I., Finn, L., Franzen, K., Fyffe, M., Frey, R., Fritschel, P., Frolov, V., Ganezer, K., Giaime, J., Goggin, L., Goda, K., Gonzalez, G., Gray, C., Gretarsson, A., Grimmett, D., Grote, H., Grunewald, S., Guenther, M., Gustafson, R., Hamilton, W., Hanna, C., Hanson, J., Hardham, C., Harry, G., Heefner, J., Heng, I., Hewitson, M., Hindman, N., Hoang, P., Hough, J., Hua, W., Ito, M., Itoh, Y., Ivanov, A., Jones, D., Johnson, W., Johnson, B., Jones, G., Kalogera, V., Katsavounidis, E., Kawabe, K., Kawamura, S., Kells, W., Khan, A., Kim, C., King, P., Klimenko, S., Koranda, S., Kozak, D., Krishnan, B., Landry, M., Lantz, B., Lazzarini, A., Lei, M., Leonor, I., Libbrecht, K., Lindquist, P., Liu, S., Mitra, S., Lormand, M., Lubinski, M., Lück, H., Luna, M., Machenschalk, B., MacInnis, M., Mageswaran, M., Mailand, K., Mikhailov, E., Malec, M., Mandic, V., Messaritaki, E., Marka, S., Maros, E., Mason, J., Mercer, R., Melissinos, A., Matone, L., Mavalvala, N., McCarthy, R., McClelland, D., McHugh, M., McNabb, J., Mendell, G., Meshkov, S., Messenger, C., Mitrofanov, V., Mitselmakher, G., Mittleman, R., Miyakawa, O., Mohanty, S., Moreno, G., Mossavi, K., Myers, E., Müller, G., Mukherjee, S., Myers, J., Nash, T., Noel, J., Nocera, F., O'Shaughnessy, R., O'Reilly, B., Ottaway, D., Pan, Y., Overmier, H., Owen, B., Papa, M., Parameswariah, C., Parameswariah, V., Pedraza, M., Penn, S., Pitkin, M., Prix, R., Quetschke, V., Raab, F., Radkins, H., Rahkola, R., Rakhmanov, M., Rawlins, K., Ray-Majumder, S., Re, T., Regimbau, T., Reitze, D., Rivera, B., Riles, K., Rodriguez, A., Robertson, D., Robertson, N., Robinson, C., Roddy, S., Rollins, J., Romano, J., Romie, J., Sarin, P., Ruet, L., Rowan, S., Rüdiger, A., Russell, P., Ryan, K., Sandberg, V., Sanders, G., Sannibale, V., Sathyaprakash, B., Saulson, P., Savage, R., Sazonov, A., Schilling, R., Schofield, R., Seader, S., Schutz, B., Schwinberg, P., Scott, S., Searle, A., Sears, B., Sellers, D., Sengupta, A., Shawhan, P., Shoemaker, D., Sibley, A., Siemens, X., Sigg, D., Sintes, A., Smith, J., Smith, M., Spjeld, O., Strain, K., Strom, D., Stuver, A., Summerscales, T., Sung, M., Sutton, P., Tanner, D., Tarallo, M., Thorne, K., Taylor, R., Veitch, J., Tokmakov, K., Torres, C., Torrie, C., Ungarelli, C., Traylor, G., Tyler, W., Ugolini, D., Vallisneri, M., van Putten, M., Vass, S., Vecchio, A., Vorvick, C., Vyachanin, S., Wallace, L., Walther, H., Ward, H., Ward, R., Watts, K., Webber, D., Weiland, U., Weinstein, A., Weiss, R., Wiley, S., Wette, K., Wen, S., Whelan, J., Whitcomb, S., Whiting, B., Willems, P., Wilkinson, C., Willke, B., Wilson, A., Woods, D., Winkler, W., Wise, S., Wiseman, A., Woan, G., Wooley, R., Worden, J., Yakushin, I., Yamamoto, H., Yoshida, S., Zanolin, M., Zhang, L., Zotov, N., Zucker, M., Zweizig, J., and The LIGO Scientific Collaboration

Subjects
Physics, Physics and Astronomy (miscellaneous), 010308 nuclear & particles physics, Gravitational wave, Detector, FOS: Physical sciences, Astrophysics, General Relativity and Quantum Cosmology (gr-qc), 01 natural sciences, LIGO, General Relativity and Quantum Cosmology, Interferometry, Amplitude, 0103 physical sciences, Range (statistics), Waveform, 010306 general physics, Sensitivity (electronics)
Abstract

We report on a search for gravitational wave bursts in data from the three LIGO interferometric detectors during their third science run. The search targets subsecond bursts in the frequency range 100-1100 Hz for which no waveform model is assumed, and has a sensitivity in terms of the root-sum-square (rss) strain amplitude of hrss ~ 10^{-20} / sqrt(Hz). No gravitational wave signals were detected in the 8 days of analyzed data., Comment: 12 pages, 6 figures. Amaldi-6 conference proceedings to be published in Classical and Quantum Gravity

Published
2005
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47. TRANSCULTURAL PERSPECTIVE ON CONSCIOUSNESS: TRADITIONAL USE OF AYAHUASCA IN PSYCHOTHERAPY IN THE 21ST CENTURY IN WESTERN WORLD.

Author

Re, T., Palma, J., Martins, J. E., and Simões, M.

Subjects
CONSCIOUSNESS, AYAHUASCA, DRUG addiction
Abstract

New research on ayahuasca's potential applications in psychiatry have been undertaken in the last few years. It is relevant to start by pointing out that this south American brew has a very low potential for abuse, having no associated psychiatric or neuropsychological disorders. P.The most studied area in which ayahuasca may be applied is drug addiction. Interest for the understanding of ayahuasca's therapeutic potential in drug addiction is to determine by which mechanism the brew acts in order to promote behavioural and personality changes that allow freedom from addiction. Some authors consider that the benefits provided by ayahuasca may arise from a symbiotic action between pharmacology and altered consciousness state, with some volunteers reporting an understanding of how some life happenings may have contributed to their depression and an achievement of a blissful state, which continued throughout time. [ABSTRACT FROM AUTHOR]

Published
2016

48. Long-term results of treatment for craniopharyngioma in children

Author

Lorenzo Bello, Bruno Ambrosi, Roberto Villani, Giovanelli Barilari M, Giustino Tomei, Erik P. Sganzerla, and Re T

Subjects
medicine.medical_specialty, Time Factors, Dose, Adolescent, medicine.medical_treatment, Craniopharyngioma, Postoperative Complications, Endocrine system, Medicine, Humans, Neoplasm Invasiveness, Radical surgery, Child, Retrospective Studies, business.industry, Brain Neoplasms, General Medicine, Long term results, medicine.disease, Magnetic Resonance Imaging, Surgery, Radiation therapy, El Niño, Pediatrics, Perinatology and Child Health, Neurology (clinical), Neurosurgery, Neoplasm Recurrence, Local, business, Tomography, X-Ray Computed, Follow-Up Studies
Abstract

Results of the treatment of 27 children with craniopharyngioma are reported. A subfrontal pterional approach was used in 55.6% of cases, a transsphenoidal and a transcallosal or transcortical approach in 25.9% and 18.5% of cases, respectively. Radical removal was the goal of surgery and was achieved in 70.8% of cases treated as primary surgery. The operative mortality was 3.7% and was due to hypothalamic failure. Most (81.4%) patients were followed up, for a mean of 7 years. Patients were evaluated according to a functional evaluation scale and outcome categories proposed by us. The scale takes account of tumor (recurrences and their eventual evolution); visual functions; endocrine functions (mainly hypothalamic), attainment of endocrine balance and drug regimen; headache; and psychosocial function. Recurrences were observed in 17.6% of patients treated with radical surgery and in 42.8% of those treated with limited surgery plus radiotherapy. A progressive amelioration of visual, endocrine and neuropsychosocial functions from the intervention to follow-up was observed in the majority of patients. Complete tumor excision was associated in 85% of cases with a low score on the functional scale, reflecting a high functional performance. Adequate substitution therapy maintained endocrine balance in 81% of patients. Since the intervention a progressive decrease in the number and dosages of medications has been observed. The majority of patients were again able to lead a normal social life. Small stature, obesity, headache, and emotional and sexual disturbances were frequent cause of long-term disability even despite adequate drug regimens. The functional evaluation scale we propose is a simple and effective tool that can be easily used during routine evaluation of patients with craniopharyngioma.

Published
1997

50. Computation of high-speed flow fields with multidimensional solid heat conduction

Author

Y-KSquire, Chen, re, T H, G Molvik, and F Milos

Subjects
Hypersonic speed, Mathematical optimization, Boundary layer, Leading edge, Materials science, Flow (mathematics), Computation, Heat transfer, Mechanics, Relativistic heat conduction, Thermal conduction
Abstract

Two methods are presented for the computation of high-speed flow fields with simultaneous multidimensional heat transfer to and within a vehicle. The first method couples a heat conduction computation with a hypersonic boundary layer code through manual iteration. The second method employs a surface energy balance to couple a multidimensional, heat transfer code with a hypersonic computational fluid dynamic code. The flow field solution and material thermal response are obtained simultaneously, which allows for the computation of timeaccurate, transient behavior. Detailed results are presented for hypersonic flow past a sharp leading edge geometry made of an advanced diboride wamic-matrix composite material.

Published
1995
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