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Objective: Smoking cessation interventions are underutilized in the surgical setting. We aimed to systematically identify the barriers and facilitators to smoking cessation in the surgical setting. Methods: Following the Joanna Briggs Institute (JBI) framework for scoping reviews, we searched 5 databases (MEDLINE, Embase, Cochrane CENTRAL, CINAHL, and PsycINFO) for quantitative or qualitative studies published in English (since 2000) evaluating barriers and facilitators to perioperative smoking cessation interventions. Data were analyzed using thematic analysis and mapped to the theoretical domains framework (TDF). Results: From 31 studies, we identified 23 unique barriers and 13 facilitators mapped to 11 of the 14 TDF domains. The barriers were within the domains of knowledge (e.g., inadequate knowledge of smoking cessation interventions) in 23 (74.2%) studies; environmental context and resources (e.g., lack of time to deliver smoking cessation interventions) in 19 (61.3%) studies; beliefs about capabilities (e.g., belief that patients are nervous about surgery/diagnosis) in 14 (45.2%) studies; and social/professional role and identity (e.g., surgeons do not believe it is their role to provide smoking cessation interventions) in 8 (25.8%) studies. Facilitators were mainly within the domains of environmental context and resources (e.g., provision of quit smoking advice as routine surgical care) in 15 (48.4%) studies, reinforcement (e.g., surgery itself as a motivator to kickstart quit attempts) in 8 (25.8%) studies, and skills (e.g., smoking cessation training and awareness of guidelines) in 5 (16.2%) studies. Conclusion: The identified barriers and facilitators are actionable targets for future studies aimed at translating evidence informed smoking cessation interventions into practice in perioperative settings. More research is needed to evaluate how targeting these barriers and facilitators will impact smoking outcomes. [ABSTRACT FROM AUTHOR]

Background and Objectives Although the association between self-reported and capacity-based mobility outcomes is prominently researched, the pathways through which self-reported measures affect capacity-based measures remains poorly understood. Therefore, our study examines the association between self-reported and capacity-based mobility measures and explores which mobility determinants mediate the association in Nigerian community-dwelling older adults. Research Design and Methods This cross-sectional study included 169 older adults [mean age (SD) = 67.7 (7.0)]. Capacity-based mobility outcomes included the Short Physical Performance Battery (SPPB), the 6-Minute Walk Test (6MWT), and the 10-Meter Walk Test (10mWT), whereas the self-reported mobility outcomes included the Lower Extremity Functional scale (LEFS), the Life Space Questionnaire (LSQ), and the Mänty Preclinical Mobility scale (inability to walk 2 km, 0.5 km, or climb a flight of stairs). Spearman's correlations were conducted to examine the relationship between self-reported and capacity-based mobility measures, whereas structural equation modeling was used to determine the mediators. Results The correlation between SPPB and LEFS (rho = 0.284) and 0.5 km (rho = −0.251) were fair, whereas the correlation between SPPB and inability to walk 2 km (rho = −0.244) and inability to climb a flight of stairs (rho = −0.190) were poor. Similarly, correlations between 6MWT and the LEFS (rho = 0.286), inability to walk 2 km (rho = −0.269), and 0.5 km (rho = −0.303) were fair. The 6WMT was poorly correlated with inability to climb one flight of stairs (rho = −0.233). The LSQ was not correlated with SPPB or 10mWT. Age was the only significant mediator, whereas the number of chronic conditions and cognitive status were not. Discussion and Implications The correlation between self-reported and capacity-based mobility outcomes in older adults in Nigeria is lower than those in developed countries. Our analysis provides a foundation to explore mobility determinants that could be predictive mediators for mobility outcomes, making meaningful contributions to explaining mobility complexities. [ABSTRACT FROM AUTHOR]

Background and Objectives The United Nations has projected a 218% increase in older people in Sub-Saharan Africa (SSA) between 2019 and 2050, underscoring the need to explore changes that would occur over this time. Longitudinal studies are ideal for studying and proffering solutions to these changes. This review aims to understand the breadth and use of longitudinal studies on aging in the SSA regions, proffering recommendations in preparation for the projected aging population. Research Design and Methods This paper is the third of a four-part series paper of a previous systematic mapping review of aging studies in SSA. We updated the search (between 2021 and 2023) and screened the titles/abstracts and full-text articles by a pair of independent reviewers. Data were extracted using a standardized data-charting form, identifying longitudinal studies in SSA. Results We identified 193 studies leveraging 24 longitudinal study data sets conducted at 28 unique sites. The World Health Organization's Study on Global AGEing and Adult Health (WHO-SAGE) (n  = 59, 30.5%) and Health and Aging in Africa: A Longitudinal Study of an INDEPTH Community in South Africa (HAALSI) (n  = 51, 26.4%) were the most used longitudinal data sets. Four studies used more than one longitudinal study data set. Eighteen of the longitudinal study data sets were used only in 1–4 studies. Most (n  = 150, 77.7%) of the studies used a cross-sectional analytical approach. Discussion and Implications Longitudinal studies on aging are sparingly being utilized in SSA. Most analyses conducted across the longitudinal data set were cross-sectional, which hindered the understanding of aging changes that occurred over time that could better inform aging policy and interventions. We call for funding bodies, such as WHO-SAGE, to develop funding competitions that focus on conducting longitudinal analyses, such as structural equation modeling, highlighting changes occurring among the aging population in SSA. [ABSTRACT FROM AUTHOR]

Aim: Multisystem inflammatory syndrome in children (MIS‐C) is a novel condition that can occur post‐SARS‐CoV‐2 infection in children and adolescents. There is a paucity of evidence on the prognostic factors associated with MIS‐C. The aim of this systematic review and meta‐analysis was to summarise the prognostic factors for MIS‐C development. Methods: Five databases were systematically searched from January 2020 to May 2023 for studies reporting on prognostic factors for MIS‐C using multivariable regression models. Random‐effects meta‐analyses were conducted to pool odds ratios for each prognostic factor. Risk of bias was rated using QUIPS and the GRADE framework was used to assess the certainty of evidence for each unique factor. Results: Twelve observational studies (N = 18 024) were included, and 13 unique prognostic factors were amenable to meta‐analysis. With moderate certainty, age <12 years, male sex and Black race probably increase the risk of MIS‐C. Malignancy and underlying respiratory disease probably decrease the risk of MIS‐C. Low‐certainty evidence suggests that Asian race may increase the risk of MIS‐C, and comorbidity may decrease the risk of MIS‐C. Conclusion: Current literature presents several prognostic factors related to MIS‐C following SARS‐CoV‐2 infection. Further research is necessary to elucidate the pathophysiologic mechanisms related to MIS‐C. [ABSTRACT FROM AUTHOR]

This systematic review and meta‐analysis of randomised controlled trials (RCTs) aimed to evaluate the efficacy, safety, and tolerability of fluvoxamine for the outpatient management of COVID‐19. We conducted this review in accordance with the PRISMA 2020 guidelines. Literature searches were conducted in MEDLINE, EMBASE, International Pharmaceutical Abstracts, CINAHL, Web of Science, and CENTRAL up to 14 September 2023. Outcomes included incidence of hospitalisation, healthcare utilization (emergency room visits and/or hospitalisation), mortality, supplemental oxygen and mechanical ventilation requirements, serious adverse events (SAEs) and non‐adherence. Fluvoxamine 100 mg twice a day was associated with reductions in the risk of hospitalisation (risk ratio [RR] 0.75, 95% confidence interval [CI] 0.58–0.97; I2 = 0%) and reductions in the risk of healthcare utilization (RR 0.68, 95% CI 0.53–0.86; I2 = 0%). While no increased SAEs were observed, fluvoxamine 100 mg twice a day was associated with higher treatment non‐adherence compared to placebo (RR 1.61, 95% CI 1.22–2.14; I2 = 53%). In subgroup analyses, fluvoxamine reduced healthcare utilization in outpatients with BMI ≥30 kg/m2, but not in those with lower BMIs. While fluvoxamine offers potential benefits in reducing healthcare utilization, its efficacy may be most pronounced in high‐risk patient populations. The observed non‐adherence rates highlight the need for better patient education and counselling. Future investigations should reassess trial endpoints to include outcomes relating to post‐COVID sequelaes. Registration: This review was prospectively registered on PROSPERO (CRD42023463829). [ABSTRACT FROM AUTHOR]

Objective: To synthesise the available evidence on physical factors, such as muscle strength and power, body mass index and their association with older adults' self-reported and performance-based mobility outcomes. Method: This review followed the Askey and O'Malley framework. We systematically searched PubMed, EMBASE, PsychINFO, Web of Science, AgeLine, Allied and Complementary Medicine Database, and Cumulative Index to Nursing and Allied Health Literature databases, from Jan. 2000 to Jan. 2022. Teams of two reviewers independently conducted title, abstract, full-text screening, and data extraction using predefined inclusion and exclusion criteria. Result: A total of 239 quantitative articles, mostly cross-sectional design, conducted in 32 countries were included in this review. We identified 18 physical factors significantly associated with mobility outcomes in the expected direction. Muscle strength, body composition, falls (number and history of), and chronic conditions (number of and type) were the most studied physical factors. Conclusion: Older adults with muscle weakness, weight concerns, history of falls, and chronic conditions had poorer mobility outcomes, such as slower gait speed, poor balance, limited community mobility and poor driving outcomes compared to their counterparts. Studies exploring the role of physical factors on the use of an assisted device, transportation, or driving, are limited. [ABSTRACT FROM AUTHOR]

Objectives: To describe the association between personality factors and mobility outcomes among community-dwelling older adults in Nigeria. Methods: This cross-sectional study included 136 older adults [mean age (SD) = 65.1 (5.4)]. The Five-Factor Model of personality was evaluated using the International Personality Item Pool. Participants' mobility was assessed using gait speed, life-space questionnaire, chair-stand and standing-balance tests. Data was analyzed using multiple linear regression. Results: Extraversion (β = 0.152, p = 0.049), conscientiousness (β = 0.238, p = 0.006), and neuroticism (β = −0.194, p = 0.016) were associated with lower extremity strength. Extraversion (β = 0.201, p = 0.021) and neuroticism (β = −0.201, p = 0.020) were associated with community mobility. No personality factor was a predictor of gait speed or balance. Conclusion: These findings may help clinicians understand the predictive power of personality and guide the development and refinement of personality-tailored interventions to improve older adults' mobility. [ABSTRACT FROM AUTHOR]