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7 results on '"Rayes, Nadine"'

1. Remotely Delivered Cancer Genetic Testing in the Making Genetic Testing Accessible (MAGENTA) Trial

Author

Swisher, Elizabeth M., primary, Rayes, Nadine, additional, Bowen, Deborah, additional, Peterson, Christine B., additional, Norquist, Barbara M., additional, Coffin, Tara, additional, Gavin, Kathleen, additional, Polinsky, Deborah, additional, Crase, Jamie, additional, Bakkum-Gamez, Jamie N., additional, Blank, Stephanie V., additional, Munsell, Mark F., additional, Nebgen, Denise, additional, Fleming, Gini F., additional, Olopade, Olufunmilayo I., additional, Law, Sherman, additional, Zhou, Alicia, additional, Levine, Douglas A., additional, D’Andrea, Alan, additional, and Lu, Karen H., additional

Published
2023
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2. Limited Independent Follow-Up with Germline Testing of Variants Detected in BRCA1 and BRCA2 by Tumor-Only Sequencing.

Author

Nowlen, Carol J., Daniels, Molly, Uzunparmak, Burak, Dumbrava, Ecaterina E. Ileana, Ying Yuan, Pate, Keyur P., Rayes, Nadine, Harkenrider, Jacqueline, Wathoo, Chetna, Veazie, Jennifer, Luna, Krystle A., Wanlin Wang, Horombe, Chacha, Javle, Milind, Ahnert, Jordi Rodon, Yap, Timothy A., Arun, Banu, Lu, Karen H., and Meric-Bernstam, Funda

Subjects
BRCA genes, HEREDITARY cancer syndromes, CANCER treatment, CANCER diagnosis, CANCER patients
Abstract

Introduction: Genomic profiling is performed in patients with advanced or metastatic cancer, in order to direct cancer treatment, often sequencing tumor-only, without a matched germline comparator. However, because many of the genes analyzed on tumor profiling overlap with those known to be associated with hereditary cancer predisposition syndromes (HCPS), tumor-only profiling can unknowingly uncover germline pathogenic (P) and likely pathogenic variants (LPV). In this study, we evaluated the number of patients with P/LPVs identified in BRCA1 and BRCA2 (BRCA1/2) via tumor-only profiling, then determined the germline testing outcomes for those patients. Methods: A retrospective chart review was performed to identify patients with BRCA1/2 variants on tumor-only genomic profiling, and whether they had germline testing. Results: This study found that of 2923 patients with 36 tumor types who underwent tumor-only testing, 554 had a variant in BRCA1/2 (19.0%); 119 of the 554 patients (21.5%) had a P/LP BRCA1/2 variant, representing 4.1% of the overall population who underwent genomic profiling. Seventy-three (61.3%) of 119 patients with BRCA1/2 P/LPV on tumor-only testing did not undergo germline testing, 34 (28.6%) had already had germline testing before tumor-only testing, and 12 (10.1%) underwent germline testing after tumor-only testing. Twenty-eight germline BRCA1/2 P/LPVs were detected, 24 in those who had prior germline testing, and 4 among the 12 patients who had germline testing after tumor-only testing. Conclusion: Tumor-only testing is likely to identify P/LPVs in BRCA1/2. Efforts to improve follow-up germline testing is needed to improve identification of germline BRCA1/2 alterations. [ABSTRACT FROM AUTHOR]

Published
2024
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3. An Accessible Communication System for Population-Based Genetic Testing: Development and Usability Study

Author

Coffin, Tara, primary, Bowen, Deborah, additional, Swisher, Elizabeth, additional, Lu, Karen, additional, Rayes, Nadine, additional, Norquist, Barbara, additional, Blank, Stephanie, additional, Levine, Douglas, additional, Bakkum-Gamez, Jamie, additional, Fleming, Gini, additional, Olopade, Olufunmilayo, additional, D’Andrea, Alan, additional, Nebgen, Denise, additional, Peterson, Christine, additional, Munsell, Mark, additional, Gavin, Kathleen, additional, Lechner, Rebecca, additional, Crase, Jamie, additional, Polinsky, Deborah, additional, and Romero, Iris, additional

Published
2022
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4. Using Social Media to Facilitate Communication About Women’s Testing: Tool Validation Study

Author

Coffin, Tara, primary, Bowen, Deborah, additional, Lu, Karen, additional, Swisher, Elizabeth M, additional, Rayes, Nadine, additional, Norquist, Barbara, additional, Blank, Stephanie V, additional, Levine, Douglas A, additional, Bakkum-Gamez, Jamie Nadine, additional, Fleming, Gini F, additional, I Olopade, Olufunmilayo, additional, Romero, Iris, additional, D'Andrea, Alan, additional, Nebgen, Denise R, additional, Peterson, Christine, additional, Munsell, Mark F, additional, Gavin, Kathleen, additional, Crase, Jamie, additional, Polinsky, Deborah, additional, and Lechner, Rebecca, additional

Published
2022
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5. Development and assessment of an accessible communication system for population-based genetic testing: Method/design (Preprint)

Author

Coffin, Tara, primary, Bowen, Deborah, additional, Swisher, Elizabeth, additional, Lu, Karen, additional, Rayes, Nadine, additional, Norquist, Barbara, additional, Blank, Stephanie, additional, Levine, Douglas, additional, Bakkum-Gamez, Jamie, additional, Fleming, Gini, additional, Olopade, Olofunmi, additional, D’Andrea, Alan, additional, Nebgen, Denise, additional, Peterson, Christine, additional, Munsell, Mark, additional, Gavin, Kathleen, additional, Lechner, Rebecca, additional, Crase, Jamie, additional, Polinsky, Deborah, additional, and Romero, Iris, additional

Published
2021
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6. Results from MAGENTA: A national randomized four-arm noninferiority trial evaluating pre- and post-test genetic counseling during online testing for breast and ovarian cancer genetic risk.

Author

Swisher, Elizabeth M., primary, Rayes, Nadine, additional, Bowen, Deborah, additional, Peterson, Christine B, additional, Coffin, Tara, additional, Norquist, Barbara, additional, Gavin, Kathleen, additional, Polinsky, Deborah, additional, Crase, Jamie, additional, Bakkum-Gamez, Jamie Nadine, additional, Blank, Stephanie V., additional, Munsell, Mark F, additional, Nebgen, Denise R, additional, Pradeep, Harsha, additional, Law, Sherman, additional, Olopade, Olufunmilayo I., additional, Zhou, Alicia, additional, Levine, Douglas A., additional, D'Andrea, Alan D., additional, and Lu, Karen H., additional

Published
2020
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7. MAGENTA (Making Genetic testing accessible): a prospective randomized controlled trial comparing online genetic education and telephone genetic counseling for hereditary cancer genetic testing

Author

Rayes, Nadine, primary, Bowen, Deborah J., additional, Coffin, Tara, additional, Nebgen, Denise, additional, Peterson, Christine, additional, Munsell, Mark F., additional, Gavin, Kathleen, additional, Lechner, Rebecca, additional, Crase, Jamie, additional, Polinsky, Deborah, additional, Romero, Iris, additional, Blank, Stephanie V., additional, Levine, Douglas A., additional, Norquist, Barbara M., additional, Swisher, Elizabeth M., additional, and Lu, Karen H., additional

Published
2019
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