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16 results on '"Rayam P"'

1. Second-harmonic generation in periodically-poled thin film lithium niobate wafer-bonded on silicon

Author

Rao, Ashutosh, Malinowski, Marcin, Honardoost, Amirmahdi, Talukder, Javed Rouf, Rabiei, Rayam, Delfyett, Peter, and Fathpour, Sasan

Subjects
Physics - Optics
Abstract

Second-order optical nonlinear effects (second-harmonic and sum-frequency generation) are demonstrated in the telecommunication band by periodic poling of thin films of lithium niobate wafer-bonded on silicon substrates and rib-loaded with silicon nitride channels to attain ridge waveguide with cross-sections of ~ 2 {\mu}m2. The compactness of the waveguides results in efficient second-order nonlinear devices. A nonlinear conversion of 8% is obtained with a pulsed input in 4 mm long waveguides. The choice of silicon substrate makes the platform potentially compatible with silicon photonics, and therefore may pave the path towards on-chip nonlinear and quantum-optic applications.

Published
2016
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3. Classes are just what the non-doctor ordered.

Author

Rayam, Sheila

Abstract

Provides information on mini-med, a school program of the University of Colorado Medical School in Denver which offers information on several health topics.

Published
2001

4. More teens using Ecstasy.

Author

Rayam, Sheila

Abstract

Discusses a report which profiles the rise in the use of the drug Ecstasy among teenagers in the United States.

Published
2000

5. Scuba safety resurfaces.

Author

Rayam, Shiela

Abstract

Presents information on a study which explored the long-term effects of scuba diving on the brain.

Published
2000

6. UNICEF: Start kids off right.

Author

Rayam, Sheila

Abstract

Presents information on the report `State of the World's Children 2001,' of the United Nations Children's Fund (UNICEF) which is about childhood care.

Published
2000

7. Kids get hard cash, software.

Author

Rayam, Sheila

Abstract

Focuses on the software access initiative of Microsoft Corp. that will provide cash and computer software to Boys & Girls Club.

Published
2000

8. Nasal strips open path to cold market.

Author

Rayam, Sheila

Abstract

Reports that CNS, the maker of Breathe Right nasal strips, released a version with Vicks Mentholated Vapors, designed to ease cold congestion.

Published
2000

9. Teens pick up phones, drop smokes.

Author

Rayam, Sheila

Abstract

Reports on the increasing sales of cellular phones to teenagers in England, and decline teen smoking rates.

Published
2000

10. Most teens admit cheating on test, lying to parents.

Author

Rayam, Sheila

Abstract

Reports that a majority of United States high school students have cheated on an exam and lied to their parents, according to a 2000 report compiled by the Josephson Institute of Ethics.

Published
2000

11. Styles vary when coping with cancer.

Author

Rayam, Sheila

Abstract

Focuses on the different methods used by patients in coping with cancer in the United States.

Published
2000

12. Surviving prostate cancer.

Author

Rayam, Sheila

Abstract

Deals with the message that Denver, Colorado Mayor Wellington Webb is conveying regarding prostate cancer.

Published
2000

13. Girls precocious but unprepared.

Author

Rayam, Sheila

Abstract

Reports on the result of a survey conducted by Applied Research and Consulting LLC and commissioned by the Girls Scouts of America which found that young girls becoming more preoccupied with body image and relationships.

Published
2000

14. Growel Like a Tiger/Run Like a Rabbit.

Author

Turton, Rayam

Subjects
FICTION
Abstract

The article reviews the books "Growl Like a Tiger" and "Run Like a Rabbit," both by Alison Lester.

Published
2013

15. Synthesis, molecular properties prediction and anticancer, antioxidant evaluation of new edaravone derivatives.

Author

Polkam N, Ramaswamy VR, Rayam P, Allaka TR, Anantaraju HS, Dharmarajan S, Perumal Y, Gandamalla D, Yellu NR, Balasubramanian S, and Anireddy JS

Subjects
Administration, Oral, Antineoplastic Agents chemical synthesis, Antineoplastic Agents chemistry, Antioxidants chemical synthesis, Antipyrine chemistry, Antipyrine pharmacology, Biological Availability, Cell Line, Tumor, Chemistry Techniques, Synthetic, Computer Simulation, Crystallography, X-Ray, Edaravone, Humans, Magnetic Resonance Spectroscopy, Antineoplastic Agents pharmacology, Antioxidants chemistry, Antioxidants pharmacology, Antipyrine analogs & derivatives
Abstract

A series of new edaravone derivatives 3-7 have been synthesized, characterised using various spectroscopic techniques and screened for their in vitro anti-cancer, antioxidant activities. Structure of 5d was further substantiated through single crystal X-ray diffraction. Among the tested, 5l exhibited pronounced activity against PC3 cancer cells. Compounds 5i, 5l, 7c showed potent activity against A549 cancer cells. Products 5k, 6, 7c demonstrated good antioxidant activity with MIC values of 18.60, 16.27, 16.07μg/mL respectively. Further the reported analogues were also tested on normal HEK293T cells and displayed low to good safer profiles. Derivatives 5l and 7c have come out to be safer potent anticancer, antioxidant agents. Additionally, the target products were subjected to their molecular properties prediction and drug likeness by employing Molinspiration and Osiris property explorer toolkits. None of them violated Lipinski's boundaries classifying the title compounds as potential anticancer and antioxidant agents., (Copyright © 2016 Elsevier Ltd. All rights reserved.)

Published
2016
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16. Synthesis, in vitro anticancer and antimycobacterial evaluation of new 5-(2,5-dimethoxyphenyl)-1,3,4-thiadiazole-2-amino derivatives.

Author

Polkam N, Rayam P, Anireddy JS, Yennam S, Anantaraju HS, Dharmarajan S, Perumal Y, Kotapalli SS, Ummanni R, and Balasubramanian S

Subjects
Anti-Bacterial Agents chemical synthesis, Anti-Bacterial Agents chemistry, Antineoplastic Agents chemical synthesis, Antineoplastic Agents chemistry, Cell Line, Tumor, Cell Proliferation drug effects, Crystallography, X-Ray, Dose-Response Relationship, Drug, Drug Screening Assays, Antitumor, HEK293 Cells, HT29 Cells, Humans, Microbial Sensitivity Tests, Models, Molecular, Molecular Structure, Structure-Activity Relationship, Anti-Bacterial Agents pharmacology, Antineoplastic Agents pharmacology, Mycobacterium smegmatis drug effects
Abstract

A series of 2,5-disubstituted-1,3,4-thiadiazole derivatives 5a-5l, 7a-7e and 9 have been synthesised and screened for in vitro antimycobacterial activity against Mycobacterium smegmatis MC-155. In addition these compounds have also been screened for cytotoxic activity against cancer cell lines HT-29, MDA-MB-231 by MTT colorimetric assay. The compounds are well characterized by spectral analysis viz. (1)H NMR, (13)C NMR, FT-IR, mass and HRMS. Screening results indicate that compounds 5g, 7a possess good antitubercular activity with MIC value 65.74 and 40.86, respectively, compounds 5g, 7a, 7b, 7d, 7e and 9 displayed promising cytotoxic activity against the cell lines tested. 5g and 7a stand out to be potent antimycobacterial and anticancer agents among the tested series. Further the title compounds were also tested on human normal cells HEK293T and are found to be safer with lesser cytotoxicity. It is interesting to observe that compound 5g has come out to be safer, potent anticancer and antimycobacterial agent., (Copyright © 2015 Elsevier Ltd. All rights reserved.)

Published
2015
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