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32 results on '"Ravera, Alice"'

4. Differential biomarker expression in heart failure patients with and without mitral regurgitation: Insights from BIOSTAT-CHF

Author

Adamo, Marianna, primary, Pagnesi, Matteo, additional, Di Pasquale, Mattia, additional, Ravera, Alice, additional, Dickstein, Kenneth, additional, Ng, Leong L., additional, Anker, Stefan D., additional, Cleland, John G., additional, Filippatos, Gerasimos S., additional, Lang, Chim C., additional, Ponikowski, Piotr, additional, Samani, Nilesh J., additional, Zannad, Faiez, additional, van Veldhuisen, Dirk J., additional, Lipsic, Erik, additional, Voors, Adriaan, additional, and Metra, Marco, additional

Published
2023
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12. Distinct pathophysiological pathways in women and men with heart failure

Author

Ravera, Alice, primary, Santema, Bernadet T., additional, de Boer, Rudolf A., additional, Anker, Stefan D., additional, Samani, Nilesh J., additional, Lang, Chim C., additional, Ng, Leong, additional, Cleland, John G.F., additional, Dickstein, Kenneth, additional, Lam, Carolyn S.P., additional, Van Spall, Harriette G. C., additional, Filippatos, Gerasimos, additional, van Veldhuisen, Dirk J., additional, Metra, Marco, additional, Voors, Adriaan A., additional, and Sama, Iziah E., additional

Published
2022
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16. Impact of mitral regurgitation in patients with worsening heart failure: insights from BIOSTAT‐CHF

Author

Pagnesi, Matteo, primary, Adamo, Marianna, additional, Sama, Iziah E., additional, Anker, Stefan D., additional, Cleland, John G., additional, Dickstein, Kenneth, additional, Filippatos, Gerasimos S., additional, Lang, Chim C., additional, Ng, Leong L., additional, Ponikowski, Piotr, additional, Ravera, Alice, additional, Samani, Nilesh J., additional, Zannad, Faiez, additional, Veldhuisen, Dirk J., additional, Voors, Adriaan A., additional, and Metra, Marco, additional

Published
2021
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17. Impact of mitral regurgitation in patients with worsening heart failure: insights from BIOSTAT-CHF

Author

Pagnesi, Matteo Adamo, Marianna Sama, Iziah E. Anker, Stefan D. Cleland, John G. Dickstein, Kenneth Filippatos, Gerasimos S. Lang, Chim C. Ng, Leong L. Ponikowski, Piotr Ravera, Alice Samani, Nilesh J. Zannad, Faiez van Veldhuisen, Dirk J. Voors, Adriaan A. Metra, Marco

Abstract

Aims Few data regarding the prevalence and prognostic impact of mitral regurgitation (MR) in patients with worsening chronic or new-onset acute heart failure (HF) are available. We investigated the role of MR in the BIOlogy Study to TAilored Treatment in Chronic Heart Failure (BIOSTAT-CHF). Methods and results We performed a retrospective post-hoc analysis including patients from both the index and validation BIOSTAT-CHF cohorts with data regarding MR status. The primary endpoint was a composite of all-cause death or HF hospitalization. Among 4023 patients included, 1653 patients (41.1%) had moderate- severe MR. Compared to others, patients with moderate- severe MR were more likely to have atrial fibrillation and chronic kidney disease and had larger left ventricular (LV) dimensions, lower LV ejection fraction (LVEF), worse quality of life, and higher plasma concentrations of N-terminal pro-B-type natriuretic peptide (NT-proBNP). A primary outcome event occurred in 697 patients with, compared to 836 patients without, moderate- severe MR [Kaplan- Meier 2-year estimate: 42.2% vs. 35.3%; hazard ratio (HR) 1.28; 95% confidence interval (CI) 1.16- 1.41; log-rank P < 0.0001]. The association between MR and the primary endpoint remained significant after adjusting for baseline variables and the previously validated BIOSTAT-CHF risk score (adjusted HR 1.11; 95% CI 1.00- 1.23; P = 0.041). Subgroup analyses showed a numerically larger impact of MR on the primary endpoint in patients with lower LVEF, larger LV end-diastolic diameter, and higher plasma NT-proBNP. Conclusions Moderate- severe MR is common in patients with worsening chronic or new-onset acute HF and is strongly associated with outcome, independently of other features related to HF severity.

Published
2021

18. Quality of life in men and women with heart failure: association with outcome, and comparison between the Kansas City Cardiomyopathy Questionnaire and the EuroQol 5 dimensions questionnaire

Author

Ravera, Alice, primary, Santema, Bernadet T., additional, Sama, Iziah E., additional, Meyer, Sven, additional, Lombardi, Carlo M., additional, Carubelli, Valentina, additional, Ferreira, João Pedro, additional, Lang, Chim C., additional, Dickstein, Kenneth, additional, Anker, Stefan D., additional, Samani, Nilesh J., additional, Zannad, Faiez, additional, van Veldhuisen, Dirk J., additional, Teerlink, John R., additional, Metra, Marco, additional, and Voors, Adriaan A., additional

Published
2021
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19. In‐hospital and long‐term mortality for acute heart failure: analysis at the time of admission to the emergency department

Author

Lombardi, Carlo, primary, Peveri, Giulia, additional, Cani, Dario, additional, Latta, Federica, additional, Bonelli, Andrea, additional, Tomasoni, Daniela, additional, Sbolli, Marco, additional, Ravera, Alice, additional, Carubelli, Valentina, additional, Saccani, Nicola, additional, Specchia, Claudia, additional, and Metra, Marco, additional

Published
2020
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20. Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin–angiotensin–aldosterone inhibitors

Author

Sama, Iziah E, primary, Ravera, Alice, additional, Santema, Bernadet T, additional, van Goor, Harry, additional, ter Maaten, Jozine M, additional, Cleland, John G F, additional, Rienstra, Michiel, additional, Friedrich, Alex W, additional, Samani, Nilesh J, additional, Ng, Leong L, additional, Dickstein, Kenneth, additional, Lang, Chim C, additional, Filippatos, Gerasimos, additional, Anker, Stefan D, additional, Ponikowski, Piotr, additional, Metra, Marco, additional, van Veldhuisen, Dirk J, additional, and Voors, Adriaan A, additional

Published
2020
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21. Identifying optimal doses of heart failure medications in men compared with women: a prospective, observational, cohort study

Author

Santema, Bernadet T, primary, Ouwerkerk, Wouter, additional, Tromp, Jasper, additional, Sama, Iziah E, additional, Ravera, Alice, additional, Regitz-Zagrosek, Vera, additional, Hillege, Hans, additional, Samani, Nilesh J, additional, Zannad, Faiez, additional, Dickstein, Kenneth, additional, Lang, Chim C, additional, Cleland, John G, additional, Ter Maaten, Jozine M, additional, Metra, Marco, additional, Anker, Stefan D, additional, van der Harst, Pim, additional, Ng, Leong L, additional, van der Meer, Peter, additional, van Veldhuisen, Dirk J, additional, Meyer, Sven, additional, Lam, Carolyn S P, additional, Voors, Adriaan A, additional, Richards, Arthur Mark, additional, Lam, Carolyn S.P., additional, Anand, Inder, additional, Hung, Chung-Lieh, additional, Ling, Lieng Hsi, additional, Liew, Houng Bang, additional, Narasimhan, Calambur, additional, Ngarmukos, Tachapong, additional, Park, Sang Weon, additional, Reyes, Eugenio, additional, Siswanto, Bambang Budi, additional, Shimizu, Wataru, additional, and Zhang, Shu, additional

Published
2019
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22. Right heart dysfunction

Author

Mercurio, Valentina, primary, Palazzuoli, Alberto, additional, Correale, Michele, additional, Lombardi, Carlo, additional, Passantino, Andrea, additional, Ravera, Alice, additional, Ruocco, Gaetano, additional, Sciatti, Edoardo, additional, Triggiani, Marco, additional, Lagioia, Rocco, additional, Scrutinio, Domenico, additional, Tocchetti, Carlo G., additional, and Nodari, Savina, additional

Published
2018
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26. Chemokines and Heart Disease: A Network Connecting Cardiovascular Biology to Immune and Autonomic Nervous Systems

Author

Dusi, Veronica, Ghidoni, Alice, Ravera, Alice, De Ferrari, Gaetano M., and Calvillo, Laura

Subjects
Article Subject
Abstract

Among the chemokines discovered to date, nineteen are presently considered to be relevant in heart disease and are involved in all stages of cardiovascular response to injury. Chemokines are interesting as biomarkers to predict risk of cardiovascular events in apparently healthy people and as possible therapeutic targets. Moreover, they could have a role as mediators of crosstalk between immune and cardiovascular system, since they seem to act as a “working-network” in deep linkage with the autonomic nervous system. In this paper we will describe the single chemokines more involved in heart diseases; then we will present a comprehensive perspective of them as a complex network connecting the cardiovascular system to both the immune and the autonomic nervous systems. Finally, some recent evidences indicating chemokines as a possible new tool to predict cardiovascular risk will be described.

Published
2016
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32. Rapid Recovery of Baroreceptor Reflexes in Acute Myocardial Infarction is a Marker of Effective Tissue Reperfusion.

Author

Ferrari, Gaetano, Sanzo, Antonio, Castelli, Grazia, Turco, Annalisa, Ravera, Alice, Badilini, Fabio, and Schwartz, Peter

Abstract

Baroreflex sensitivity (BRS) measured several days after myocardial infarction (MI) is a powerful predictor of cardiovascular mortality. No information is available on BRS in the early hours of MI. The possibility to reliably assess BRS in the acute phase of MI and its clinical correlates were evaluated in 45 patients treated with primary percutaneous coronary intervention (pPCI). BRS (sequence method) was assessed 1, 3, 6, and 12 h after PCI. ST resolution (STRes) was considered present if ST had decreased ≥70 % 3 h after PCI. BRS was 10.7 ± 6.2 1 h after PCI; at 12 h it was 15.4 ± 5.2 and 8.4 ± 4.8 ms/mmHg in patients with and without STRes, respectively ( p < 0.001). STRes was an independent predictor of 12 h BRS ( p = 0.005) and of 1-12 h BRS difference ( p = 0.002). BRS can be reliably assessed in the first hours of MI; it shows a rapid recovery in patients with STRes and a significant depression in patients without STres. [ABSTRACT FROM AUTHOR]

Published
2014
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