Search

Background: Treatment with hyaluronic acid (HA) fillers as a strategy for rejuvenation has experienced a significant growth in recent years, accompanied by a parallel increase in its complications, the treatment of which, such as hyaluronidase, we must be aware of., Patients/methods: 14 patients (28 eyes) had indication for upper blepharoplasty surgery in the Hospital Universitario y Politécnico La Fe. After surgery, periocular skin of one eye of each patient was infiltrated with 300 U of hyaluronidase (14 cases) while the skin of the fellow eye was preserved untreated (14 controls). All samples were studied by the Pathology department, and finally, 6 variables (skin structure alteration, degeneration of elastic fibers, deposits, collagen fibers destructuring, inflammation, and other findings) were analyzed., Results: No differences in skin structure, elastic fibers, and collagen dermal fibers were found between hyaluronidase-treated skin and controls. A significant association between ex vivo application of hyaluronidase in periocular skin and the presence of amorphous extracellular deposits within the dermis was found., Conclusions: Hyaluronidase applied ex vivo to periocular skin led to presence of deposits within the extracellular matrix compared to control eyelid skin but elastin and collagen dermis structure remained unaltered., (© 2022 Wiley Periodicals LLC.)

Objectives: Mesonephric adenocarcinoma is a rare clinical entity, predominantly appearing in women, involved in great controversy about its histogenesis. Reported cases to date were not diagnosed in their initial stages and they were treated by radical surgery with poor results., Methods: We report the case of a 71-year-old male with previous diagnosis of nephrogenic adenoma two years before., Results: After the diagnosis of mesonephric adenocarcinoma was established, patient underwent radical surgery despite its poor prognosis., Conclusions: Differential diagnosis between these tumors should be made with primary or metastatic adenocarcinoma and nephrogenic adenoma. We highlight the ongoing controversy in the literature in relation to malignant evolution of the nephrogenic adenoma as etiology of the rare mesonephric adenocarcinoma. In this case, previous finding of a nephrogenic adenoma would support that theory.

Fifteen cases of nasosinusal inverted papilloma treated in our department from 1994 to 2000 are reported. The most frequent initial symptom was unilateral nasal obstruction. Some others symptoms were rhinorrea, facial pain and self limited epistaxis. The most frequent surgical procedure performed was the paralateral rhinotomy with medial maxillectomy. The median average for the follow up was 28 months, being diagnosed one recurrence. The paralateral rhinotomy with a medial maxillectomy, under functional endoscopic nasosinusal techniques are being more and more used, decreasing the indications of open techniques.