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2. Automatic Detection of Optic Disc and Fovea from Colour Fundus Images

Author

Martinez-Perez, M. Elena, Elze, Tobias, Rauscher, Franziska G., Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, and Arai, Kohei, editor

Published
2024
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5. Association of Systemic Medication Use with Glaucoma and Intraocular Pressure: The European Eye Epidemiology Consortium

Author

Vergroesen, Joëlle E., Schuster, Alexander K., Stuart, Kelsey V., Asefa, Nigus G., Cougnard-Grégoire, Audrey, Delcourt, Cécile, Schweitzer, Cédric, Barreto, Patrícia, Coimbra, Rita, Foster, Paul J., Luben, Robert N., Pfeiffer, Norbert, Stingl, Julia V., Kirsten, Toralf, Rauscher, Franziska G., Wirkner, Kerstin, Jansonius, Nomdo M., Arnould, Louis, Creuzot-Garcher, Catherine P., Stricker, Bruno H., Keskini, Christina, Topouzis, Fotis, Bertelsen, Geir, Eggen, Anne E., Bikbov, Mukharram M., Jonas, Jost B., Klaver, Caroline C.W., Ramdas, Wishal D., and Khawaja, Anthony P.

Published
2023
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9. Robust Automatic Montaging of Adaptive Optics Flood Illumination Retinal Images

Author

Valterova, Eva, Rauscher, Franziska G., Kolar, Radim, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Papież, Bartłomiej W., editor, Yaqub, Mohammad, editor, Jiao, Jianbo, editor, Namburete, Ana I. L., editor, and Noble, J. Alison, editor

Published
2021
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16. Phenome- and genome-wide analyses of retinal optical coherence tomography images identify links between ocular and systemic health.

Author

Zekavat, Seyedeh Maryam, Jorshery, Saman Doroodgar, Rauscher, Franziska G., Horn, Katrin, Sekimitsu, Sayuri, Koyama, Satoshi, Nguyen, Trang T., Costanzo, Maria C., Jang, Dongkeun, Burtt, Noël P., Kühnapfel, Andreas, Shweikh, Yusrah, Ye, Yixuan, Raghu, Vineet, Zhao, Hongyu, Ghassemi, Marzyeh, Elze, Tobias, Segrè, Ayellet V., Wiggs, Janey L., and Del Priore, Lucian

Subjects
OPTICAL coherence tomography, MACULAR degeneration, GENOME-wide association studies, GENETIC markers, EYE care
Abstract

The human retina is a multilayered tissue that offers a unique window into systemic health. Optical coherence tomography (OCT) is widely used in eye care and allows the noninvasive, rapid capture of retinal anatomy in exquisite detail. We conducted genotypic and phenotypic analyses of retinal layer thicknesses using macular OCT images from 44,823 UK Biobank participants. We performed OCT layer cross-phenotype association analyses (OCT-XWAS), associating retinal thicknesses with 1866 incident conditions (median 10-year follow-up) and 88 quantitative traits and blood biomarkers. We performed genome-wide association studies (GWASs), identifying inherited genetic markers that influence retinal layer thicknesses and replicated our associations among the LIFE-Adult Study (N = 6313). Last, we performed a comparative analysis of phenome- and genome-wide associations to identify putative causal links between retinal layer thicknesses and both ocular and systemic conditions. Independent associations with incident mortality were detected for thinner photoreceptor segments (PSs) and, separately, ganglion cell complex layers. Phenotypic associations were detected between thinner retinal layers and ocular, neuropsychiatric, cardiometabolic, and pulmonary conditions. A GWAS of retinal layer thicknesses yielded 259 unique loci. Consistency between epidemiologic and genetic associations suggested links between a thinner retinal nerve fiber layer with glaucoma, thinner PS with age-related macular degeneration, and poor cardiometabolic and pulmonary function with a thinner PS. In conclusion, we identified multiple inherited genetic loci and acquired systemic cardio-metabolic-pulmonary conditions associated with thinner retinal layers and identify retinal layers wherein thinning is predictive of future ocular and systemic conditions. Editor's summary: Changes in retinal thickness are thought to be linked to systemic diseases. Zekavat and colleagues performed a cross-phenotype analysis using retinal optical coherence tomography (OCT) images from the UK Biobank and identified associations between retinal layer thickness and incident ocular, neuropsychiatric, and cardiometabolic diseases during a median 10-year follow-up. Genome-wide associations identified 259 loci linked to retinal layer thickness and revealed concordant genetic and phenotypic associations between OCT retinal layer thickness and certain ocular and systemic conditions. These results suggest that OCT imaging might be used to derive retinal markers for systemic and ocular health, but further validation of clinical utility is needed. —Daniela Neuhofer [ABSTRACT FROM AUTHOR]

Published
2024
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18. Automated detection of genetic relatedness from fundus photographs using Siamese Neural Networks

Author

Bhandari, Sakshi Manoj, primary, Singh, Praveer, additional, Arun, Nishanth, additional, Sekimitsu, Sayuri, additional, Raghu, Vineet, additional, Rauscher, Franziska G., additional, Elze, Tobias, additional, Horn, Katrin, additional, Kirsten, Toralf, additional, Scholz, Markus, additional, Segre, Ayellet V., additional, Wiggs, Janey L., additional, Kalpathy-Cramer, Jayashree, additional, and Zebardast, Nazlee, additional

Published
2023
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19. The LIFE Child study: a population-based perinatal and pediatric cohort in Germany

Author

the LIFE Child study team, Poulain, Tanja, Baber, Ronny, Vogel, Mandy, Pietzner, Diana, Kirsten, Toralf, Jurkutat, Anne, Hiemisch, Andreas, Hilbert, Anja, Kratzsch, Jürgen, Thiery, Joachim, Fuchs, Michael, Hirsch, Christian, Rauscher, Franziska G., Loeffler, Markus, Körner, Antje, Nüchter, Matthias, and Kiess, Wieland

Published
2017

20. Insights into human health from phenome- and genome-wide analyses of UK Biobank retinal optical coherence tomography phenotypes

Author

Zekavat, Seyedeh Maryam, primary, Doroodgar Jorshery, Saman, additional, Shweikh, Yusrah, additional, Rauscher, Franziska G., additional, Sekimitsu, Sayuri, additional, Kayoma, Satoshi, additional, Ye, Yixuan, additional, Raghu, Vineet, additional, Zhao, Hongyu, additional, Ghassemi, Marzyeh, additional, Elze, Tobias, additional, Segre, Ayellet V., additional, Wiggs, Janey L., additional, Scholz, Markus, additional, Del Priore, Lucian, additional, Wang, Jay C., additional, Natarajan, Pradeep, additional, and Zebardast, Nazlee, additional

Published
2023
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23. Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease

Author

Winkler, Thomas W., Grassmann, Felix, Brandl, Caroline, Kiel, Christina, Günther, Felix, Strunz, Tobias, Weidner, Lorraine, Zimmermann, Martina E., Korb, Christina A., Poplawski, Alicia, Schuster, Alexander K., Müller-Nurasyid, Martina, Peters, Annette, Rauscher, Franziska G., Elze, Tobias, Horn, Katrin, Scholz, Markus, Cañadas-Garre, Marisa, McKnight, Amy Jayne, Quinn, Nicola, Hogg, Ruth E., Küchenhoff, Helmut, Heid, Iris M., Stark, Klaus J., and Weber, Bernhard H. F.

Published
2020
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24. Association of lipid-lowering drugs and antidiabetic drugs with age-related macular degeneration: a meta-analysis in Europeans.

Author

Mauschitz, Matthias M., Verzijden, Timo, Schuster, Alexander K., Elbaz, Hisham, Pfeiffer, Norbert, Khawaja, Anthony, Luben, Robert N., Foster, Paul J., Rauscher, Franziska G., Wirkner, Kerstin, Kirsten, Toralf, Jonas, Jost B., Bikbov, Mukharram M., Hogg, Ruth, Peto, Tunde, Cougnard-Grégoire, Audrey, Bertelsen, Geir, Erke, Maja Gran, Topouzis, Fotis, and Giannoulis, Dimitrios A.

Abstract

Background/aims To investigate the association of commonly used systemic medications with prevalent age-related macular degeneration (AMD) in the general population. Methods We included 38 694 adults from 14 population-based and hospital-based studies from the European Eye Epidemiology consortium. We examined associations between the use of systemic medications and any prevalent AMD as well as any late AMD using multivariable logistic regression modelling per study and pooled results using random effects meta-analysis. Results Between studies, mean age ranged from 61.5±7.1 to 82.6±3.8 years and prevalence ranged from 12.1% to 64.5% and from 0.5% to 35.5% for any and late AMD, respectively. In the meta-analysis of fully adjusted multivariable models, lipid-lowering drugs (LLD) and antidiabetic drugs were associated with lower prevalent any AMD (OR 0.85, 95% CI=0.79 to 0.91 and OR 0.78, 95% CI=0.66 to 0.91). We found no association with late AMD or with any other medication. Conclusion Our study indicates a potential beneficial effect of LLD and antidiabetic drug use on prevalence of AMD across multiple European cohorts. Our findings support the importance of metabolic processes in the multifactorial aetiology of AMD. [ABSTRACT FROM AUTHOR]

Published
2023
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28. Comprehensive automatic processing and analysis of adaptive optics flood illumination retinal images on healthy subjects

Author

Valterova, Eva, Unterlauft, Jan D, Francke, Mike, Kirsten, Toralf, Kolar, Radim, and Rauscher, Franziska G

Subjects
retinal imaging, image procesing, 610 Medizin und Gesundheit, cone detection, Atomic and Molecular Physics, and Optics, Article, Biotechnology, adaptive optics
Abstract

This work presents a novel fully automated method for retinal analysis in images acquired with a flood illuminated adaptive optics retinal camera (AO-FIO). The proposed processing pipeline consists of several steps: First, we register single AO-FIO images in a montage image capturing a larger retinal area. The registration is performed by combination of phase correlation and the scale-invariant feature transform method. A set of 200 AO-FIO images from 10 healthy subjects (10 images from left eye and 10 images from right eye) is processed into 20 montage images and mutually aligned according to the automatically detected fovea center. As a second step, the photoreceptors in the montage images are detected using a method based on regional maxima localization, where the detector parameters were determined with Bayesian optimization according to manually labeled photoreceptors by three evaluators. The detection assessment, based on Dice coefficient, ranges from 0.72 to 0.8. In the next step, the corresponding density maps are generated for each of the montage images. As a final step, representative averaged photoreceptor density maps are created for the left and right eye and thus enabling comprehensive analysis across the montage images and a straightforward comparison with available histological data and other published studies. Our proposed method and software thus enable us to generate AO-based photoreceptor density maps for all measured locations fully automatically, and thus it is suitable for large studies, as those are in pressing need for automated approaches. In addition, the application MATADOR (MATlab ADaptive Optics Retinal Image Analysis) that implements the described pipeline and the dataset with photoreceptor labels are made publicly available.

Published
2023

30. Association of retinal fibre layer thickness with cognition in a population‐based study

Author

Rauscher, Franziska G., primary, Girbardt, Johanna, additional, Luck, Tobias, additional, Kynast, Jana, additional, Rodriguez, Francisca S., additional, Witte, A. Veronica, additional, Wang, Mengyu, additional, Engel, Christoph, additional, Loeffler, Markus, additional, Villringer, Arno, additional, Riedel‐Heller, Steffi G., additional, Schroeter, Matthias L., additional, and Elze, Tobias, additional

Published
2022
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31. Association of lipid-lowering drugs and antidiabetic drugs with age-related macular degeneration: a meta-analysis in Europeans

Author

Mauschitz, Matthias M, primary, Verzijden, Timo, additional, Schuster, Alexander K, additional, Elbaz, Hisham, additional, Pfeiffer, Norbert, additional, Khawaja, Anthony, additional, Luben, Robert N, additional, Foster, Paul J, additional, Rauscher, Franziska G, additional, Wirkner, Kerstin, additional, Kirsten, Toralf, additional, Jonas, Jost B, additional, Bikbov, Mukharram M, additional, Hogg, Ruth, additional, Peto, Tunde, additional, Cougnard-Grégoire, Audrey, additional, Bertelsen, Geir, additional, Erke, Maja Gran, additional, Topouzis, Fotis, additional, Giannoulis, Dimitrios A, additional, Brandl, Caroline, additional, Heid, Iris M, additional, Creuzot-Garcher, Catherine P, additional, Gabrielle, Pierre-Henry, additional, Hense, Hans-Werner, additional, Pauleikhoff, Daniel, additional, Barreto, Patricia, additional, Coimbra, Rita, additional, Piermarocchi, Stefano, additional, Daien, Vincent, additional, Holz, Frank G, additional, Delcourt, Cecile, additional, and Finger, Robert P, additional

Published
2022
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33. Association of lipid-lowering drugs, anti-diabetic drugs, non-steroidal anti-inflammatory drugs, and levodopa with age-related macular degeneration in Europeans: A meta-analysis of the European Eye Epidemiology (E3) - consortium

Author

Mauschitz, Matthias M., Schuster, Alexander Karl-Georg, Khawaja, Anthony P., Bikbov, Mukharram, Hogg, Ruth E., Rauscher, Franziska G., Erke, Maja Gran, Topouzis, Fotis, Brandl, Caroline, Creuzot‐Garcher, Catherine, Delcourt, Cecile, Hense, Hans-Werner, Silva, Rufino, Piermarocchi, Stefano, Ritchie, Karen, Finger, Robert, and Julien, Sabine

Subjects
[SDV] Life Sciences [q-bio], [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, [SDV.MHEP.OS] Life Sciences [q-bio]/Human health and pathology/Sensory Organs
Abstract

Purpose : Changes in lipid metabolism, chronic inflammation and increased oxidative stress have been discussed as patho-etiogenetic drivers in age-related macular degeneration (AMD). Systemic medication, such as lipid-lowering drugs (LLD) and anti-diabetic drugs, affect these pathways and may therefore also play a role in AMD pathogenesis. We aimed to investigate associations of commonly used systemic drugs with AMD prevalence in the European population.Methods : We included 38,694 adults from 14 population-based studies from the European Eye Epidemiology (E3) consortium. We performed multivariable logistic regression modelling to examine medication use association with prevalence of AMD as well as late AMD. Analyses were carried out separately by study and results pooled using random effects meta-analysis. We conducted these analyses separately for LLD, anti-diabetic drugs, non-steroidal anti-inflammatory drugs (NSAID), and L-Dopa.Results : Between studies, mean age ranged from 61.5 ± 7.1 to 82.6 ± 3.8 years and prevalence ranged from 12.1% to 64.5% and from 0.5% to 35.5% for any and any late AMD, respectively. In the meta-analysis of our multivariable models, LLD and anti-diabetic drugs were associated with lower AMD prevalence (OR 0.85, 95% confidence interval (CI)=0.79 - 0.91 and OR 0.78, 95% CI=0.66 - 0.91). We found no association with late AMD or with any other medication.Conclusions : Our study shows an association of LLD and anti-diabetic drug use with lower AMD prevalence across multiple European cohorts. Our findings support the importance of metabolic processes in the complex etiology of AMD.

Published
2022

34. E-Science-Tage 2021

Author

Heuveline, Vincent, Bisheh, Nina, Bauer, Theresia, Eitel, Bernhard, Jüptner, Patrick, Dalibor, Manuela, Trautwein-Bruns, Ute, Rumpe, Bernhard, Demleitner, Markus, Landwehr, Matthias, Schneider, Gabriel, Hofmann, Stefan, Razum, Matthias, Soltau, Kerstin, Peschel, Thomas, Wang, Mengyu, Kirsten, Toralf, Rauscher, Franziska G., Elze, Tobias, Kölzsch, Andrea, Safi, Kamran, Leipold, Luca, Straka, Janine, Yahosseini, Kyanoush S., Grönewald, Matthias, Mund, Patrick, Bodenbrenner, Matthias, Fuhrmans, Marc, Heinrichs, Benedikt, Müller, Matthias S., Pelz, Peter F., Politze, Marius, Preuß, Nils, Schmitt, Robert H., Stäcker, Thomas, Mozgova, Iryna, Jagusch, Gerald, Freund, Jens, Kraft, Angelina, Glück, Tobias, Herrmann, Kevin, Knöchelmann, Marvin, Lachmayer, Roland, Ganske, Anette, Voss, Vivien, Kaiser, Amandine, Heil, Angelika, Lammert, Andrea, Mühlhaus, Timo, Brillhaus, Dominik, Tschöpe, Marcel, Maus, Oliver, Grüning, Björn, Garth, Christoph, Martins Rodrigues, Cristina, Von Suchodoletz, Dirk, Claus, Florian, Curdt, Constanze, Kather, Jens, Rehwald, Stephanie, Sohmen, Lucia, Rack, Fabian, Schlesinger, Claus-Michael, Ulrich, Mona, Hein, Pascal, Blessing, André, Buck, Nina, Schembera, Björn, Kushnarenko, Volodymyr, Ganzenmüller, Andreas, Kiss, Lisa, Horvat, Julia, Nedostup, Oksana, Hartmann, Thomas, Martens, Claudia, Bensberg, Sarah, Barthel, Robert, Salk, Jürgen, Böker, Elisabeth, Langer, André, Tran, Bach, Gaedke, Martin, Niekamp, Rainer, Gutfleisch, Oliver, Schröder, Jörg, Naujoks, Julian, Droß, Patrick J., Cyra, Magdalene, Fingerhuth, Matthias, Hirsch, Markus, Iglezakis, Dorothea, Leymann, Frank, Zimmermann, Michael, Schimmler, Sonja, Bönisch, Thomas, Horsch, Martin Thomas, Petrenko, Taras, Wentzel, Bianca, Kirstein, Fabian, Viemann, Harald, Holeňa, Martin, Linke, David, Nestler, Britta, Berger, Marco, Dierend, Hauke, Farnbacher, Benjamin, Flemisch, Bernd, Gläser, Dennis, Heine, Ina, Hoppe, Nils, Lemmer, Jan, Linxweiler, Jan, Metzmacher, Amelie I., Richter, Manuela, Roski, Stefanie, Schlenz, Hartmut, Selzer, Michael, Stemmer, Christian, Baumann, Martin, Heß, Florian, Maylein, Leonhard, Mechler, Tatjana, Scherbaum, Benjamin, Volkmann, Eric, Hahn, Ulrich, Bauer, Jonathan, Glogowski, Kolja, Seifert, Mark, Herklotz, Markus, Oberländer, Lars, Gehrlein, Sabine, Schumm, Irene, Shigapov, Renat, Timm, Henning, Wittkamp, Anne, Beyer, Stefan, Schmolke, Lukas, Arnold, Denis, Lang, Christian, Schmidt, Christian, Ferrando-May, Elisa, Hess, Jan, Holz, Alexander, Jung, Kerstin, Kramski, Heinz Werner, Kaminski, Andreas, Kamzelak, Roland S., Kuhn, Jonas, Viehhauser, Gabriel, Gauza, Holger, Wannenmacher, Fabian, Werner, Johannes, Zajac, Thomas, Krüger, Jens, Jabeen, Hajira, Usadel, Björn, Lukasczyk, Jonas, Venn, Benedikt, Kraft, Sophie, Seitz-Moskaliuk, Hendrik, Sure-Vetter, York, Wössner, Elena, Bohmer, Nils, Eufinger, Jan, Fluck, Juliane, Koepler, Oliver, Korbel, Jan, Miller, Bernhard, Pittroff, Sarah, Schwetje, Thorsten, Weber, Judith Sophie, Bösert, Frauke, Siebler, Sven, Skopnik, Paul, Sundermann, Jan Erik, Blask, Katarina, Müller, Marie-Luise, Latz, Marc, Arnold, Valentin, Kraffert, Stephanie, Strobl, Marcus, Azmi, Elnaz, Hassler, Sibylle K., Mälicke, Mirko, Meyer, Jörg, Streit, Achim, Zehe, Erwin, Arendt, Thorsten, Koutsou, Achilleas, Mittal, Deepti, Sehara, Keisuke, Schuppner, Rike-Benjamin, Larkum, Matthew, Wachtler, Thomas, Colomb, Julien, Geßner, Hendrik, Blümm, Mirjam, Förstner, Konrad U., Lanczek, Marvin, Lindstädt, Birte, Müller, Rabea, Nickenig, Ulrike, Slowig, Benjamin, Stegemann, Jessica, Richling, Sabine, Balz, Alexander, and Kühl, Robert

Published
2022
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35. Additional file 3 of Renal function and lipid metabolism are major predictors of circumpapillary retinal nerve fiber layer thickness���the LIFE-Adult Study

Author

Rauscher, Franziska G., Wang, Mengyu, Francke, Mike, Wirkner, Kerstin, T��njes, Anke, Engel, Christoph, Thiery, Joachim, Stenvinkel, Peter, Stumvoll, Michael, Loeffler, Markus, Elze, Tobias, and Ebert, Thomas

Abstract

Additional file 3: Table S2. Sectoral analyses derived from cpRNFLT in all subjects with further adjustment for high sensitivity c-reactive protein (N = 8,952).

Published
2022
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36. Additional file 6 of Renal function and lipid metabolism are major predictors of circumpapillary retinal nerve fiber layer thickness���the LIFE-Adult Study

Author

Rauscher, Franziska G., Wang, Mengyu, Francke, Mike, Wirkner, Kerstin, T��njes, Anke, Engel, Christoph, Thiery, Joachim, Stenvinkel, Peter, Stumvoll, Michael, Loeffler, Markus, Elze, Tobias, and Ebert, Thomas

Subjects
lipids (amino acids, peptides, and proteins)
Abstract

Additional file 6: Table S5. Sectoral multivariable linear regression analyses for lipid markers and cpRNFLT in all subjects stratified by statin treatment.

Published
2022
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37. Additional file 2 of Renal function and lipid metabolism are major predictors of circumpapillary retinal nerve fiber layer thickness���the LIFE-Adult Study

Author

Rauscher, Franziska G., Wang, Mengyu, Francke, Mike, Wirkner, Kerstin, T��njes, Anke, Engel, Christoph, Thiery, Joachim, Stenvinkel, Peter, Stumvoll, Michael, Loeffler, Markus, Elze, Tobias, and Ebert, Thomas

Subjects
genetic structures, sense organs, eye diseases
Abstract

Additional file 2: Table S1. Sectoral multivariable linear regression analyses for cardiometabolic biomarkers and cpRNFLT in all subjects with further adjustment for SD-OCT-derived clinical and subclinical ONH abnormalities (including glaucoma and other ONH diseases), as well as patient-reported glaucoma diagnosis and medication (N = 8952).

Published
2022
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38. Additional file 8 of Renal function and lipid metabolism are major predictors of circumpapillary retinal nerve fiber layer thickness���the LIFE-Adult Study

Author

Rauscher, Franziska G., Wang, Mengyu, Francke, Mike, Wirkner, Kerstin, T��njes, Anke, Engel, Christoph, Thiery, Joachim, Stenvinkel, Peter, Stumvoll, Michael, Loeffler, Markus, Elze, Tobias, and Ebert, Thomas

Subjects
genetic structures, sense organs, eye diseases
Abstract

Additional file 8: Table S7. Sectoral analyses derived from cpRNFLT in patients with optic nerve head abnormalities, self-reported glaucoma diagnosis, and/or glaucoma medication (N = 1,180).

Published
2022
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39. Additional file 5 of Renal function and lipid metabolism are major predictors of circumpapillary retinal nerve fiber layer thickness���the LIFE-Adult Study

Author

Rauscher, Franziska G., Wang, Mengyu, Francke, Mike, Wirkner, Kerstin, T��njes, Anke, Engel, Christoph, Thiery, Joachim, Stenvinkel, Peter, Stumvoll, Michael, Loeffler, Markus, Elze, Tobias, and Ebert, Thomas

Abstract

Additional file 5: Table S4. Baseline characteristics of the entire study population stratified by statin treatment.

Published
2022
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40. Additional file 4 of Renal function and lipid metabolism are major predictors of circumpapillary retinal nerve fiber layer thickness���the LIFE-Adult Study

Author

Rauscher, Franziska G., Wang, Mengyu, Francke, Mike, Wirkner, Kerstin, T��njes, Anke, Engel, Christoph, Thiery, Joachim, Stenvinkel, Peter, Stumvoll, Michael, Loeffler, Markus, Elze, Tobias, and Ebert, Thomas

Subjects
urologic and male genital diseases, female genital diseases and pregnancy complications
Abstract

Additional file 4: Table S3. Baseline characteristics of the entire study population stratified by CKD risk status.

Published
2022
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42. Additional file 7 of Renal function and lipid metabolism are major predictors of circumpapillary retinal nerve fiber layer thickness���the LIFE-Adult Study

Author

Rauscher, Franziska G., Wang, Mengyu, Francke, Mike, Wirkner, Kerstin, T��njes, Anke, Engel, Christoph, Thiery, Joachim, Stenvinkel, Peter, Stumvoll, Michael, Loeffler, Markus, Elze, Tobias, and Ebert, Thomas

Abstract

Additional file 7: Table S6. Bayesian information criterion difference (��BIC) for the investigation of potential mediating effects of smoking status on the association between cpRNFLT and the lipid profile.

Published
2022
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43. Cohort Profile: The LIFE-Adult-Study.

Author

Engel, Christoph, Wirkner, Kerstin, Zeynalova, Samira, Baber, Ronny, Binder, Hans, Ceglarek, Uta, Enzenbach, Cornelia, Fuchs, Michael, Hagendorff, Andreas, Henger, Sylvia, Hinz, Andreas, Rauscher, Franziska G, Reusche, Matthias, Riedel-Heller, Steffi G, Röhr, Susanne, Sacher, Julia, Sander, Christian, Schroeter, Matthias L, Tarnok, Attila, and Treudler, Regina

Subjects
RETICULOCYTES, FERRITIN, THYROTROPIN receptors, CLINICAL neuropsychology, HDL cholesterol, LDL cholesterol, GENERAL practitioners, MEDICAL ethics, LIQUID chromatography-mass spectrometry
Abstract

Google Scholar Crossref Search ADS PubMed WorldCat 7 Quante M, Hesse M, Dohnert M et al.; LIFE Child Study Investigators. Google Scholar Crossref Search ADS PubMed WorldCat 9 Enzenbach C, Wicklein B, Wirkner K, Loeffler M. Evaluating selection bias in a population-based cohort study with low baseline participation: the LIFE-Adult-Study. Google Scholar Crossref Search ADS PubMed WorldCat 2 Holle R, Happich M, Lowel H, Wichmann HE; MONICA/KORA Study Group. Key Features The LIFE-Adult-Study is a population-based cohort study investigating the prevalence and incidence of common diseases and subclinical disease phenotypes, the complex interactions between genetic and lifestyle factors regarding the co-occurrence and development of subclinical phenotypes and diseases, and the role of biomarkers to predict disease initiation and progression. [Extracted from the article]

Published
2023
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44. Reading cognition from the eyes—association of retinal nerve fiber layer thickness with cognitive performance in a population-based study

Author

Girbardt, Johanna, primary, Luck, Tobias, additional, Kynast, Jana, additional, Rodriguez, Francisca S, additional, Wicklein, Barbara, additional, Wirkner, Kerstin, additional, Engel, Christoph, additional, Girbardt, Christian, additional, Wang, Mengyu, additional, Polyakova, Maryna, additional, Witte, A Veronica, additional, Loeffler, Markus, additional, Villringer, Arno, additional, Riedel-Heller, Steffi G, additional, Schroeter, Matthias L, additional, Elze, Tobias, additional, and Rauscher, Franziska G, additional

Published
2021
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46. The Leipzig Health Atlas—An Open Platform to Present, Archive, and Share Biomedical Data, Analyses, and Models Online.

Author

Kirsten, Toralf, Meineke, Frank A., Loeffler-Wirth, Henry, Beger, Christoph, Uciteli, Alexandr, Stäubert, Sebastian, Löbe, Matthias, Hänsel, René, Rauscher, Franziska G., Schuster, Judith, Peschel, Thomas, Herre, Heinrich, Wagner, Jonas, Zachariae, Silke, Engel, Christoph, Scholz, Markus, Rahm, Erhard, Binder, Hans, and Loeffler, Markus

Abstract

Background Clinical trials, epidemiological studies, clinical registries, and other prospective research projects, together with patient care services, are main sources of data in the medical research domain. They serve often as a basis for secondary research in evidence-based medicine, prediction models for disease, and its progression. This data are often neither sufficiently described nor accessible. Related models are often not accessible as a functional program tool for interested users from the health care and biomedical domains. Objective The interdisciplinary project Leipzig Health Atlas (LHA) was developed to close this gap. LHA is an online platform that serves as a sustainable archive providing medical data, metadata, models, and novel phenotypes from clinical trials, epidemiological studies, and other medical research projects. Methods Data, models, and phenotypes are described by semantically rich metadata. The platform prefers to share data and models presented in original publications but is also open for nonpublished data. LHA provides and associates unique permanent identifiers for each dataset and model. Hence, the platform can be used to share prepared, quality-assured datasets and models while they are referenced in publications. All managed data, models, and phenotypes in LHA follow the FAIR principles, with public availability or restricted access for specific user groups. Results The LHA platform is in productive mode (). It is already used by a variety of clinical trial and research groups and is becoming increasingly popular also in the biomedical community. LHA is an integral part of the forthcoming initiative building a national research data infrastructure for health in Germany. [ABSTRACT FROM AUTHOR]

Published
2022
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48. Additional file 1 of Renal function and lipid metabolism are major predictors of circumpapillary retinal nerve fiber layer thickness���the LIFE-Adult Study

Author

Rauscher, Franziska G., Wang, Mengyu, Francke, Mike, Wirkner, Kerstin, T��njes, Anke, Engel, Christoph, Thiery, Joachim, Stenvinkel, Peter, Stumvoll, Michael, Loeffler, Markus, Elze, Tobias, and Ebert, Thomas

Abstract

Additional file 1: Figure S1. Scatterplots illustrating the relationship between global circumpapillary retinal nerve fiber layer thickness (cpRNFLT) and major clinical markers of renal function.

Published
2021
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