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16. Air sampling and determination of vapours and aerosols of bitumen and polycyclic aromatic hydrocarbons in the Human Bitumen Study

Author

Breuer, Dietmar, Hahn, Jens-Uwe, Höber, Dieter, Emmel, Christoph, Musanke, Uwe, Rühl, Reinhold, Spickenheuer, Anne, Raulf-Heimsoth, Monika, Bramer, Rainer, Seidel, Albrecht, Schilling, Bernd, Heinze, Evelyn, Kendzia, Benjamin, Marczynski, Boleslaw, Welge, Peter, Angerer, Jürgen, Brüning, Thomas, and Pesch, Beate

Published
2011
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20. Influence of Welding Fume on Systemic Iron Status

Author

Casjens, Swaantje, Henry, Jana, Rihs, Hans-Peter, Lehnert, Martin, Raulf-Heimsoth, Monika, Welge, Peter, Lotz, Anne, Van Gelder, Rainer, Hahn, Jens-Uwe, Stiegler, Hugo, Eisele, Lewin, Weiss, Tobias, Hartwig, Andrea, Brüning, Thomas, and Pesch, Beate

Published
2014
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31. An Official American Thoracic Society Workshop Report: Presentations and Discussion of the Sixth Jack Pepys Workshop on Asthma in the Workplace

Author

Tarlo, Susan M, Malo, Jean-Luc, de Blay, Frédéric, Le Moual, Nicole, Henneberger, Paul K, Heederik, Dick, Raulf-Heimsoth, Monika, Carlsten, Christopher, Cartier, André, ATS Assembly on Environmental, Occupational, and Population Health, Dep IRAS, LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-I&I RA, Dep IRAS, LS IRAS EEPI GRA (Gezh.risico-analyse), and dIRAS RA-I&I RA

Subjects
Pulmonary and Respiratory Medicine, Occupational therapy, medicine.medical_specialty, Population, MEDLINE, Pulmonary disease, Article, Toxicology, Pulmonary Disease, Chronic Obstructive, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Occupational Exposure, Epidemiology, medicine, Humans, 030212 general & internal medicine, Asthma, Occupational, education, Societies, Medical, Asthma, education.field_of_study, business.industry, Allergens, medicine.disease, Causality, United States, respiratory tract diseases, 030228 respiratory system, Family medicine, Practice Guidelines as Topic, Irritants, business, Occupational asthma
Abstract

The Sixth Jack Pepys Workshop on Asthma in the Workplace focused on six key themes regarding the recognition and assessment of work-related asthma and airway diseases: (1) cleaning agents and disinfectants (including in swimming pools) as irritants and sensitizers: how to evaluate types of bronchial reactions and reduce risks; (2) population-based studies of occupational obstructive diseases: use of databanks, advantages and pitfalls, what strategies to deal with biases and confounding?; (3) damp environments, dilapidated buildings, recycling processes, and molds, an increasing problem: mechanisms, how to assess causality and diagnosis; (4) diagnosis of occupational asthma and rhinitis: how useful are recombinant allergens (component-resolved diagnosis), metabolomics, and other new tests?; (5) how does exposure to gas, dust, and fumes enhance sensitization and asthma?; and (6) how to determine probability of occupational causality in chronic obstructive pulmonary disease: epidemiological and clinical, confirmation, and compensation aspects. A summary of the presentations and discussion is provided in this proceedings document. Increased knowledge has been gained in each topic over the past few years, but there remain aspects of controversy and uncertainty requiring further research.

Published
2017
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46. Research needs in allergy: an EAACI position paper, in collaboration with EFA

Author

Papadopoulos Nikolaos G, Agache Ioana, Bavbek Sevim, Bilo Beatrice M, Braido Fulvio, Cardona Victoria, Custovic Adnan, deMonchy Jan, Demoly Pascal, Eigenmann Philippe, Gayraud Jacques, Grattan Clive, Heffler Enrico, Hellings Peter W, Jutel Marek, Knol Edward, Lötvall Jan, Muraro Antonella, Poulsen Lars K, Roberts Graham, Schmid-Grendelmeier Peter, Skevaki Chrysanthi, Triggiani Massimo, vanRee Ronald, Werfel Thomas, Flood Breda, Palkonen Susanna, Savli Roberta, Allegri Pia, Annesi-Maesano Isabella, Annunziato Francesco, Antolin-Amerigo Dario, Apfelbacher Christian, Blanca Miguel, Bogacka Ewa, Bonadonna Patrizia, Bonini Matteo, Boyman Onur, Brockow Knut, Burney Peter, Buters Jeroen, Butiene Indre, Calderon Moises, Cardell Lars, Caubet Jean-Christoph, Celenk Sevcan, Cichocka-Jarosz Ewa, Cingi Cemal, Couto Mariana, deJong Nicolette, Del Giacco Stefano, Douladiris Nikolaos, Fassio Filippo, Fauquert Jean-Luc, Fernandez Javier, Rivas Montserrat, Ferrer Marta, Flohr Carsten, Gardner James, Genuneit Jon, Gevaert Philippe, Groblewska Anna, Hamelmann Eckard, Hoffmann Hans, Hoffmann-Sommergruber Karin, Hovhannisyan Lilit, Hox Valérie, Jahnsen Frode L, Kalayci Ömer, Kalpaklioglu Ayse, Kleine-Tebbe Jörg, Konstantinou George, Kurowski Marcin, Lau Susanne, Lauener Roger, Lauerma Antti, Logan Kirsty, Magnan Antoine, Makowska Joanna, Makrinioti Heidi, Mangina Paraskevi, Manole Felicia, Mari Adriano, Mazon Angel, Mills Clare, Mingomataj ErvinÇ, Niggemann Bodo, Nilsson Gunnar, Ollert Markus, O'Mahony Liam, O'Neil Serena, Pala Gianni, Papi Alberto, Passalacqua Gianni, Perkin Michael, Pfaar Oliver, Pitsios Constantinos, Quirce Santiago, Raap Ulrike, Raulf-Heimsoth Monika, Rhyner Claudio, Robson-Ansley Paula, Alves Rodrigo, Roje Zeljka, Rondon Carmen, Rudzeviciene Odilija, Ruëff Franziska, Rukhadze Maia, Rumi Gabriele, Sackesen Cansin, Santos Alexandra F, Santucci Annalisa, Scharf Christian, Schmidt-Weber Carsten, Schnyder Benno, Schwarze Jürgen, Senna Gianenrico, Sergejeva Svetlana, Seys Sven, Siracusa Andrea, Skypala Isabel, Sokolowska Milena, Spertini Francois, Spiewak Radoslaw, Sprikkelman Aline, Sturm Gunter, Swoboda Ines, Terreehorst Ingrid, Toskala Elina, Traidl-Hoffmann Claudia, Venter Carina, Vlieg-Boerstra Berber, Whitacker Paul, Worm Margitta, Xepapadaki Paraskevi, and Akdis Cezmi A

Subjects
Allergy, Allergic diseases, Policy, Research needs, Research funding, Europe, Immunologic diseases. Allergy, RC581-607
Abstract

Abstract In less than half a century, allergy, originally perceived as a rare disease, has become a major public health threat, today affecting the lives of more than 60 million people in Europe, and probably close to one billion worldwide, thereby heavily impacting the budgets of public health systems. More disturbingly, its prevalence and impact are on the rise, a development that has been associated with environmental and lifestyle changes accompanying the continuous process of urbanization and globalization. Therefore, there is an urgent need to prioritize and concert research efforts in the field of allergy, in order to achieve sustainable results on prevention, diagnosis and treatment of this most prevalent chronic disease of the 21st century. The European Academy of Allergy and Clinical Immunology (EAACI) is the leading professional organization in the field of allergy, promoting excellence in clinical care, education, training and basic and translational research, all with the ultimate goal of improving the health of allergic patients. The European Federation of Allergy and Airways Diseases Patients’ Associations (EFA) is a non-profit network of allergy, asthma and Chronic Obstructive Pulmonary Disorder (COPD) patients’ organizations. In support of their missions, the present EAACI Position Paper, in collaboration with EFA, highlights the most important research needs in the field of allergy to serve as key recommendations for future research funding at the national and European levels. Although allergies may involve almost every organ of the body and an array of diverse external factors act as triggers, there are several common themes that need to be prioritized in research efforts. As in many other chronic diseases, effective prevention, curative treatment and accurate, rapid diagnosis represent major unmet needs. Detailed phenotyping/endotyping stands out as widely required in order to arrange or re-categorize clinical syndromes into more coherent, uniform and treatment-responsive groups. Research efforts to unveil the basic pathophysiologic pathways and mechanisms, thus leading to the comprehension and resolution of the pathophysiologic complexity of allergies will allow for the design of novel patient-oriented diagnostic and treatment protocols. Several allergic diseases require well-controlled epidemiological description and surveillance, using disease registries, pharmacoeconomic evaluation, as well as large biobanks. Additionally, there is a need for extensive studies to bring promising new biotechnological innovations, such as biological agents, vaccines of modified allergen molecules and engineered components for allergy diagnosis, closer to clinical practice. Finally, particular attention should be paid to the difficult-to-manage, precarious and costly severe disease forms and/or exacerbations. Nonetheless, currently arising treatments, mainly in the fields of immunotherapy and biologicals, hold great promise for targeted and causal management of allergic conditions. Active involvement of all stakeholders, including Patient Organizations and policy makers are necessary to achieve the aims emphasized herein.

Published
2012
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47. Bovine Allergens in a Ruminant Clinic and Dairy Barns: Exposure Levels, Determinants, and Variability

Author

Samadi, Sadegh, Heederik, Dick J J, Zahradnik, Eva, Rietbroek, Nancy N J, van Eerdenburg, Frank, Sander, Ingrid, Raulf-Heimsoth, Monika, Wouters, Inge M, dFAH AVR, dIRAS RA-I&I RA, One Health Microbieel, Dep IRAS, LS IRAS EEPI GRA (Gezh.risico-analyse), Sub Junior Docenten, and LS GZ Landbouwhuisdieren

Subjects
exposure, variability, bovine allergens, dairy barn, Coronacrisis-Taverne, ruminant clinic, allergy, determinant, sensitization
Abstract

Background: Dairy farmers may develop specific sensitization and allergic airway diseases due to bovine allergens. However, dose-response relationships are lacking, and as yet little is known on bovine allergen exposure levels. Objective: To investigate bovine allergen exposure levels in a ruminant clinic and dairy barns, and to assess exposure determinants and variability of exposure. Methods: Samples were collected using active and passive airborne dust measurements in a ruminant clinic and several dairy barns. Bovine allergen levels were determined by sandwich enzyme-linked immunosorbent assay. Linear mixed models were applied to explore the association between bovine allergen exposure levels and potential exposure determinants. Day-to-day within-worker and between-worker exposure variability was determined, as well as how exposure determinants affect exposure variability. Results: Bovine allergens were measureable in all samples. Personal bovine allergen exposure levels in the ruminant clinic ranged from 0.10 to 24.8 µg/m3, geometric mean (GM) 1.34 µg/m3. Exposure levels varied dependent on job titles. Personal exposure levels in dairy barns ranged from 0.10 to 46.8 µg/m3, GM 1.47 µg/m3. Type of bedding materials in the barns appeared to be a significant determinant of bovine allergen levels. Compost bedding, particularly, increased allergen levels. Milking by robot was the most important determinant explaining between-worker exposure variability, while bedding was important as well. Bovine allergen levels in stationary measurements were somewhat lower than personal measurements (GM ratio 0.47). Bovine allergens could be readily detected in electrostatic dust-fall collector measurements. Conclusion: This study provides insight in bovine allergen exposure levels and their determinants, which is a first step to investigate dose-response relationships between sensitization/allergy associated with exposure to bovine allergen levels in future studies.

Published
2018

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