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Objective: To compare Open Appendectomy and Laparoscopic Appendectomy in the treatment of perforated Appendicitis. Study Design: Quasi-experimental study. Place and Duration of Study: Department of Surgery, Combined Military Hospital, Abbottabad Pakistan, from Dec 2016 to Jan 2022. Methodology: A total of 240 patients underwent either open (Group-A) or laparoscopic (Group-B) appendectomy. Patients of Perforated Appendicitis fulfilling inclusion criteria were included in the study after getting informed consent. Variables of operative time, hospital stays, surgical site infection and Intra-abdominal infection were recorded. Results: Mean operating time for the Open Appendectomy-Group (49.7±6.10 minutes) was significantly shorter than the time of Laparoscopic Surgery-Group (58.93±5.41 minutes; p<0.001). The mean hospitalization time was shorter (2.57±0.77 days) in Laparoscopic Appendectomy than Open Surgery-Group (3.23±0.62 days, p=0.001). Two port sites (6.7%) in the Laparoscopic Group and nine surgical sites (30.0%) in the Open Surgery-Group got infected (p=0.021). Two patients (6.7%) in Open Appendectomy-Group and three patients (10.0%) in Laparoscopic Appendectomy-Group had postoperative complication of intra-abdominal abscess (p=1.00). Conclusion: As compared to open approach, laparoscopic appendectomy had significantly lesser surgical site infections, shorter hospital stays and longer operating time. There was no statistically significant difference in the intra-abdominal infection in both techniques. [ABSTRACT FROM AUTHOR]

Background: Chronic respiratory diseases such as asthma are often caused by a variety of variables, and there is growing interest in the role of hormones, especially those related to the female menstrual cycle. Objective: The purpose of the study was to elucidate the relationship between the menstrual cycle and the symptoms of asthma in female patients. Methodology: The purpose of the cross-sectional research, which was carried out at Liaquat Memorial Hospital Kohat, Women and Children hospital Abbottabad, Khyber Teaching Hospital Peshawar and Poonch Medical College/ CMH Rawalakot AJK from January 2020 to March 2021, was to explore the impact of menstruation on asthma symptoms in female patients. According to the authorized research design, female patients who visited emergency department, gynae opd, were given a thorough health questionnaire to complete in order to prospectively gather data. Menstrual-Related Asthma (MLA) was self-identified by the subjects, who ranged in age from 14 to 45. Spirometric readings were taken after the questionnaire. Several health-related characteristics were taken into consideration while comparing participants with and without MLA using statistical analysis, which included chisquare tests and logistic regression. Results: In our study involving 240 female participants (76.19% response rate), 13.33% reported MLA. Pregnant women with MLA had substantially greater rates of asthma exacerbations (52.38% vs. 29.18%, p=0.032) and higher incidence of allergies (p<0.001). Although the frequencies of symptoms were similar in both groups, women with MLA reported greater doses of rescue medicine (53.33% vs. 37.29%, p=0.010) and more chest tightness (38.09% vs. 27.56%, p=0.101). MLA was linked to more urgent/emergent medical visits, especially to the emergency department (p=0.034), and asthma-related absenteeism (54.76% vs. 36.75%, p=0.003). In comparison to women without MLA, those with MLA also had greater rates of eczema (n=13; 30.95%), heart disease (n=5; 11.90%), and rheumatoid arthritis (n=5; 11.90%). Conclusion: The results of this thorough study highlight the need for customized interventions to meet the particular healthcare needs of women with MLA. They also show a significant correlation between MLA in female patients and distinct exacerbations, increased reliance on rescue medication, elevated asthma-related absenteeism, and a higher prevalence of comorbid health conditions. [ABSTRACT FROM AUTHOR]