495 results on '"Rau, T."'
Search Results
2. MRI-guided active surveillance without re-biopsy in patients with ISUP 1 and 2 prostate cancer – results of radical prostatectomy and mid-term follow up of the prospective PROMM-AS study
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Radtke, J.P., primary, Al-Monajjed, R., additional, Arsov, C., additional, Valentin, B., additional, Ullrich, T., additional, Boschheidgen, M., additional, Hadaschik, B., additional, Giganti, F., additional, Giessing, M., additional, Lopez-Cotarelo, C., additional, Rau, T., additional, Esposito, I., additional, Antoch, G., additional, Schimmöller, L., additional, and Albers, P., additional
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- 2024
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3. MRI-guided active surveillance in patients with ISUP 1 prostate cancer – A multi-institutional validation of the discrimination of the PRECISE Score
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Sushentsev, N., primary, Wiesenfarth, M., additional, Dixius, M., additional, Kastner, C., additional, Borkowetz, A., additional, Platzek, I., additional, Thomas, C., additional, Kesch, C., additional, Umutlu, L., additional, Reis, H., additional, Rau, T., additional, Lenders, L., additional, Spahn, M., additional, Boschheidgen, M., additional, Antoch, G., additional, Albers, P., additional, Barrett, T., additional, Schimmöller, L., additional, Hadaschik, B., additional, and Radtke, J.P., additional
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- 2024
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4. MRI-guided active surveillance in patients with ISUP 1 prostate cancer - a multi-institutional validation of the discrimination of the PRECISE score
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Radtke, JP, Sushentsev, N, Wiesenfarth, M, Dixius, M, Kastner, C, Borkowetz, A, Thomas, C, Platzke, I, Kesch, C, Umutlu, L, Reis, H, Rau, T, Lenders, L, Spahn, M, Boschheidgen, M, Antoch, G, Barrett, T, Schimmöller, L, Hadaschik, B, Radtke, JP, Sushentsev, N, Wiesenfarth, M, Dixius, M, Kastner, C, Borkowetz, A, Thomas, C, Platzke, I, Kesch, C, Umutlu, L, Reis, H, Rau, T, Lenders, L, Spahn, M, Boschheidgen, M, Antoch, G, Barrett, T, Schimmöller, L, and Hadaschik, B
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- 2024
5. MRI-guided active surveillance in patients with ISUP 1 and 2 prostate cancer - results of radical prostatectomy and follow up of the PROMM-AS study
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Radtke, JP, Al-Monajjed, R, Arsov, C, Valentin, B, Ullrich, T, Boschheidgen, M, Hadaschik, B, Giganti, F, Gießing, M, Lopez-Cotarelo, C, Rau, T, Esposito, I, Antoch, G, Schimmöller, L, Albers, P, Radtke, JP, Al-Monajjed, R, Arsov, C, Valentin, B, Ullrich, T, Boschheidgen, M, Hadaschik, B, Giganti, F, Gießing, M, Lopez-Cotarelo, C, Rau, T, Esposito, I, Antoch, G, Schimmöller, L, and Albers, P
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- 2024
6. Broken Symmetry Groups, Tables, and Structural Images in the Computer Experiment
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Rau, V. G., Lomtev, L. A., and Rau, T. F.
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- 2019
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7. Broken Symmetry Group in the Octahedral [Me(urea)6]2+, 3+ Cation With Chelate Hydrogen Bonds
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Rau, V. G., Rau, T. F., Lomtev, L. A., and Nikitin, O. R.
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- 2018
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8. Time to first recurrence, pattern of recurrence, and survival after recurrence in endometrial cancer according to the molecular classification
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Siegenthaler, F, Lindemann, K, Epstein, E, Rau, T T, Nastic, D, Ghaderi, M, Rydberg, F, Mueller, M D, Carlson, J, and Imboden, S
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Cohort Studies ,Oncology ,Humans ,570 Life sciences ,biology ,Obstetrics and Gynecology ,Female ,610 Medicine & health ,Neoplasm Recurrence, Local ,Tumor Suppressor Protein p53 ,Prognosis ,Endometrial Neoplasms ,Retrospective Studies - Abstract
OBJECTIVE Despite its generally favorable prognosis at primary diagnosis, recurrence of endometrial cancer remains an important clinical challenge. The aim of this study was to analyze the value of molecular classification in recurrent endometrial cancer. METHODS This study included patients with recurrent endometrial cancer who underwent primary surgical treatment between 2004 and 2015 at the Karolinska University Hospital, Sweden and the Bern University Hospital, Switzerland (KImBer cohort) with molecular classification of the primary tumor. RESULTS Out of 594 molecularly classified endometrial cancer patients, 101 patients experienced recurrence, consisting of 2 POLEmut, 33 MMRd, 30 p53abn, and 36 NSMP tumors. Mean age at recurrence was 71 years and mean follow-up was 54 months. Overall, median time to first recurrence was 16 months (95% CI 12-20); with the shortest median time in MMRd patients, with 13 months (95% CI 5-21). The pattern of recurrence was distinct among molecular subgroups: MMRd tumors experienced more locoregional, while p53abn cases showed more abdominal recurrences (P = .042). Median survival after recurrence was best for MMRd cases (43 months, 95% CI 11-76), compared to 39 months (95% CI 21-57) and 10 months (95% CI 7-13) for the NSMP and p53abn cases respectively (log-rank, P = .001). CONCLUSION Molecular classification is a significant indicator of survival after recurrence in endometrial cancer patients, and patterns of recurrence differ by molecular subgroups. While MMRd endometrial cancer show more locoregional recurrence and the best survival rates after recurrence, p53abn patients experience abdominal recurrence more often and had the worst prognosis of all recurrent patients.
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- 2022
9. Comparison of immediate and intermediate-term results of intravascular ultrasound versus angiography-guided Palmaz-Schatz stent implantation in matched lesions.
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Albiero, R, Rau, T, Schlüter, M, Di Mario, C, Reimers, B, Mathey, DG, Tobis, JM, Schofer, J, and Colombo, A
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Coronary Vessels ,Humans ,Coronary Disease ,Recurrence ,Coronary Angiography ,Ultrasonography ,Retrospective Studies ,Stents ,Adult ,Aged ,Middle Aged ,Female ,Male ,stents ,coronary disease ,ultrasonics ,angiography ,restenosis ,Cardiovascular System & Hematology ,Clinical Sciences ,Cardiorespiratory Medicine and Haematology ,Public Health and Health Services - Abstract
BackgroundIntravascular ultrasound (IVUS) provides more precise information than angiography about vascular dimensions. This information is used by some centers to optimize intracoronary stent implantation. There are no direct comparisons of the effects on restenosis of optimal IVUS-guided versus angiography-directed high-pressure stenting.Methods and resultsLesions of patients who had a 6-month angiographic follow-up study were eligible for matching. From 445 consecutive lesions treated by Palmaz-Schatz (P-S) stenting guided by IVUS (IVUS group) in Milan, 173 lesions were individually matched with 173 of 476 consecutive lesions treated by P-S stenting directed by angiography (Angio group) in Hamburg. Lesions were selected by a computerized program according to baseline clinical, angiographic, and procedural variables. Immediate and 6-month angiographic results were retrospectively compared, distinguishing an "early phase" from a "late phase." This distinction was based on the more aggressive dilation strategy with larger balloons and more demanding IVUS criteria for optimal stent expansion used in Milan in the early phase. In both phases, a larger minimum lumen diameter (MLD) immediately after stenting and after 6 months was achieved in the IVUS group than in the Angio group. In the early phase, the dichotomous restenosis rate was lower in the IVUS group than in the Angio group (9.2% versus 22.3%; P=.04). In the late phase, there was no difference in restenosis between the groups (22.7% versus 23.7%; P=1.0).ConclusionsIn matched lesions treated with high-pressure stenting, IVUS guidance achieved a larger MLD than angiographic guidance. However, in the IVUS group, the restenosis rate was lower only in the early phase, when balloons larger than currently used were selected to maximize the stent lumen area.
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- 1997
10. Hereditäres Dickdarmkarzinom: Ein Update zu Genetik und Entitäten aus differenzialdiagnostischer Sicht
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Rau, T. T., Dawson, H., Hartmann, A., and Rüschoff, J.
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- 2017
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11. Pathogenetische Aspekte bei Vorläuferläsionen gastrointestinaler Tumoren
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Rau, T.
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- 2016
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12. Multi-colour FISH in oesophageal adenocarcinoma—predictors of prognosis independent of stage and grade
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Geppert, C-I, Rümmele, P, Sarbia, M, Langer, R, Feith, M, Morrison, L, Pestova, E, Schneider-Stock, R, Hartmann, A, Rau, T T, Geppert, C-I, Rümmele, P, Sarbia, M, Langer, R, Feith, M, Morrison, L, Pestova, E, Schneider-Stock, R, Hartmann, A, and Rau, T T
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- 2022
13. Transfection studies using a new cardiac 3D gel system
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Eschenhagen, T., Fink, C., Rau, T., Remmers, U., Weil, J., Zimmermann, W. H., Aigner, S., Eppenberger, H. M., Wakatsuki, T., Elson, E. L., Hasenfuss, Gerd, editor, and Marbán, Eduardo, editor
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- 2000
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14. 76. Comparing the effect of disinfectants on pork abattoir surface hygiene after sanitation
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D'Souza, D.N., primary, Vandewinkel, P., additional, Hewitt, R.J.E., additional, and Rau, T., additional
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- 2021
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15. 836 Implementation of the 2021 molecular ESGO/ESTRO/ESP risk groups in endometrial cancer
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Imboden, S, primary, Nastic, D, additional, Ghaderi, M, additional, Siegenthaler, F, additional, Mueller, M, additional, Rau, T, additional, Epstein, E, additional, and Carlson, J, additional
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- 2021
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16. Differenzialdiagnostik erblicher Dickdarmkarzinomsyndrome: Der Beitrag der Pathologie
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Rüschoff, J., Heinmöller, E., Hartmann, A., Büttner, R., and Rau, T.
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- 2010
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17. Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
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Ridker PM, Everett BM, Thuren T, MacFadyen JG, Chang WH, Ballantyne C, Fonseca F, Nicolau J, Koenig W, Anker SD, Kastelein JJP, Cornel JH, Pais P, Pella D, Genest J, Cifkova R, Lorenzatti A, Forster T, Kobalava Z, Vida-Simiti L, Flather M, Shimokawa H, Ogawa H, Dellborg M, Rossi PRF, Troquay RPT, Libby P, Glynn RJ, Novo S, Krum H, Varigos J, Siostrzonek P, Sinnaeve P, Gotcheva N, Yong H, Urina-Triana M, Milicic D, Vettus R, Manolis AJ, Wyss F, Sigurdsson A, Fucili A, Veze I, Petrauskiene B, Salvador L, Klemsdal TO, Medina F, Budaj A, Otasevic P, Lainscak M, Seung KB, Commerford P, Donath M, Hwang JJ, Kultursay H, Bilazarian S, East C, Forgosh L, Harris B, Ligueros M, Bohula E, Charmarthi B, Cheng S, Chou S, Danik J, McMahon G, Maron B, Ning M, Olenchock B, Pande R, Perlstein T, Pradhan A, Rost N, Singhal A, Taqueti V, Wei N, Burris H, Cioffi A, Dalseg AM, Ghosh N, Gralow J, Mayer T, Rugo H, Fowler V, Limaye AP, Cosgrove S, Levine D, Lopes R, Scott J, Hilkert R, Tamesby G, Mickel C, Manning B, Woelcke J, Tan M, Manfreda S, Ponce T, Kam J, Saini R, Banker K, Salko T, Nandy P, Tawfik R, O’Neil G, Manne S, Jirvankar P, Lal S, Nema D, Jose J, Collins R, Bailey K, Blumenthal R, Colhoun H, Gersh B, Abreu M, Actis MV, Aiub J, Aiub F, Albisu J, Alvarisqueta A, Avalos V, Barreto M, Berli MA, Blumberg C, Bocanera M, Botta C, Bowen L, Budassi N, Buhlman S, Westberg JC, Carabajal T, Caruso G, Casala J, Cendali G, Coloma G, Berra FC, Cuneo C, Degennaro N, Dellasa M, Diaz M, Dos Santos P, Espinosa V, Facello A, Facello M, Farias E, Fernandez AA, Ferrari V, Pacora FF, Flores GS, Franco M, Gabito A, Viola HG, Garcia F, Garcia Duran R, Garcia Pinna J, Glenny J, Godoy Sanchez M, Grosse A, Guzman P, Hasbani E, Hominal M, Ibañez J, Jure H, Jure D, Vico ML, Liniado G, Luciardi H, Luquez H, Maehara G, Maffei L, Majul C, Mallagray M, Marinaro S, Martinez J, Massaccesi R, De Los Milagros Had M, Azize GM, Montana O, Montenegro E, Morell Y, Muntaner J, Navarrete S, Olmedo M, Paganini M, Paz S, Perez Manghi F, Piskorz D, Polato C, Recoaro R, Romano A, Salinger M, Sanchez A, Saravia MA, Sarjanovich R, Scaro G, Schiavi LB, Soler J, Tinnirello V, Tomassi A, Valle M, Vallejo MA, Venturini C, Marcela Wenetz LM, Yossen M, Zaidman C, Zalazar L, Zangroniz P, Amerena J, Brady L, Colquhoun D, Eccleston D, Ferreira-Jardim A, French J, Jayasinghe R, Mcintosh C, Ord M, Plotz M, Purnell P, Roberts-Thomson P, Schultz C, Shanahan T, Tan R, Taverner P, Turner F, Vibert J, Vorster M, William M, Youssef G, Bergler-Klein J, Brath H, Brodmann M, Fliesser-Goerzer E, Haider K, Heeren G, Hiden C, Mandic L, Paulweber B, Ploechl A, Prenner A, Steringer-Mascherbauer R, Strohner-Kaestenbauer H, Barbato E, Bouvy C, Briké C, Charlier F, Cools F, De Knijf K, De Wolf L, Delforge M, Deweerdt N, Gits F, Goffinet C, Hermans K, Hollanders G, Mestdagh I, Pirenne B, Servaes V, Simons N, Tahon S, Theunissen E, Van Genechten G, Vervoort G, Vissers C, Vranckx P, Vrolix M, Abib E Jr, Abrantes J, Araujo Fonseca M, Barbosa E, Barroso W, Barroso A, Bodanese L, Botelho R, Costa Amorim R, Da Costa F, Da Silva A, Da Silva O Jr, Da Silva D Jr, Ferreira Dos Santos T, Dos Santos F, Dos Santos A, Duda N, Feitosa G, Felario Junior GA, Ferraz R, Filho P, Fonseca A, Wanderley FF, Freitas E, Fucci F, Marengo Garcia De Carvalho L, Hernandez M, Hettwer Magedanz E, Julião K, Kormann A, Lameira A, Lima F, Lino E, Maia L, Manenti E, Marchi AL, Fischer SM, Michalaros Y, Moraes J Jr, Moreira L, Pagnan M, Pesce F, Pinheiro L, Rassi S, Reis G, Reis H, Resende I, Roel A, Ruschel K, Saporito W, Saraiva JF, Seroqui M, Silva R, Unterkircher B, Vicente C, Vieira N, Xavier JP, Zucchetti C, Angelova I, Dimitrov G, Genova D, Gospodinov K, Goudev A, Grigorova V, Hristova K, Makedonska JJ, Katova T, Kostov K, Lazov P, Manov E, Manukov I, Manukov D, Milanova M, Kabakchieva VM, Petrov D, Petrusheva T, Pramatarova I, Raev D, Runev N, Sirakova-Taseva A, Tisheva-Gospodinova S, Todorova A, Tzekova M, Yakovova S, Yanev T, Abulencia K, Arora S, Baker A, Bata IR, Beaudry M, Belle Isle J, Bilodeau N, Boivin MC, Bolduc H, Bourgeois S, Brons S, Cantor W, Chaussé I, Chhabra A, Chouinard G, Cleveland T, Dattani D, Deslongchamps F, Diodati J, Drouin K, Duchesne L, Fontaine S, d'Amours DG, Gervais B, Gosselin G, Graham J, Grover A, Gupta A, Haldane H, Hartleib M, Hickey L, Huynh T, Johnston J, Julien VE, Lachance P, Lake J, Lamontagne C, Lauzon C, Lepage S, Maheux K, Manyari D, Martin E, McPherson C, Mehta S, Michaud N, Kouz SM, Murphy G, OKeefe D, Otis R, Ouimet F, Pandey S, Peck C, Perkins L, Richert L, Robbins K, Robinson S, Cabau JR, Ross B, Roy C, Roy M, Roy A, Rupka D, Affaki GS, Saunders K, Savard D, Soucy D, St Amour E, Thiessen S, Vertes G, Vezina M, Vincelli G, Weisnagel SJ, Zadra R, Chen J, Chen Y, Dong X, Feng Y, Feng Z, Fu G, Han B, Hao Y, He Y, He Z, Hong T, Jia Z, Jiang T, Jiang J, Jiang X, Ke Y, Li Y, Li Z, Li W, Li X, Liu P, Liu Y, Liu B, Liu S, Liu L, Lu Z, Lv Y, Ma C, Ma G, Peng L, Qing L, Ren L, Sang X, Song M, Sun Z, Wang J, Wang Y, Wei J, Wu W, Wu J, Xu H, Yan J, Yang P, Yang K, Yao Z, Yaoqing H, Yuan Z, Zhai Z, Zhang J, Zhang Y, Zhao R, Zhou H, Accini Mendoza JL, Aparicio CV, Castillo T, Chaverra I, Conrado Y, Coronel J, Cotes C, Cuentas I, Cuervo A, Dussan MA, Echeverria L, Hernandez E, Ibarra J, Isaza D, Jimenez D, Lopez P, Manzur F, Mejia I, Mendoza Y, Molina DI, Patino JM, Rodriguez D, Rodriguez LM, Rodriguez SM, Sanchez Vallejo G, Luz Serrano H, Sotomayor A, Urina M, Vesga B, Yupanqui H, Akrap B, Busic N, Ciglenecki N, Cmrecnjak J, Fucak E, Gabor M, Jeric M, Jutrisa N, Kordic K, Planinc I, Popovic Z, Radeljic V, Sesto I, Sutalo K, Tusek S, Belohlavek J, Budkova J, Busak L, Capova L, Cech V, Cermak O, Coufalova Z, Cyprian R, Dedek V, Dedkova S, Ferkl R, Hanak P, Hanustiakova A, Homza M, Horackova K, Houra M, Iveta H, Kaiserova L, Kala P, Karel I, Kellnerova I, Koleckar P, Kreckova M, Krupicka J, Lorenc Z, Machova V, Malik J, Masarikova L, Matyasek I, Mikus M, Mikusova T, Ondrasik J, Otava M, Palubova L, Pavlickova L, Peterka M, Petrova I, Pokorna B, Povolny P, Radvan M, Reznakova S, Rickova Z, Roszkowska P, Rotreklova M, Samkova D, Skalicka H, Slechticka A, Sternthal P, Telekes P, Tesak M, Vesely P, Vesely J, Vins P, Vitovec M, Vodnansky P, Zidova M, Keba E, Laane E, Pool T, Randvee L, Ratnik E, Reimand M, Reinmets S, Rivis L, Siemann M, Stern M, Toom M, Vahula V, Apel T, Axthelm C, Ayasse D, Ayasse M, Baar M, Baeumer A, Bagi ES, Becker B, Binder A, Blankenberg S, Braun P, Johansen BB, Contzen C, Delfonso F, Denecke C, Dengler T, Donaubauer T, Eichinger G, Englmann E, Erhard M, Faghih M, Foerster A, Frankenstein L, Fuchs R, Furch G, Gaeb-Strasas B, Germann H, Giese C, Goette A, Gravenhorst-Muenter U, Haege R, Haenel T, Hagemann D, Hagenow A, Hanefeld M, Heider J, Heisters J, Hennig D, Hielscher S, Himpel-Boenninghoff A, Holscher A, Hornig M, Jeserich M, Kaczmarek N, Kanitz S, Kara YD, Khariouzov A, Kiefer R, Kiroglu K, Klamm M, Klein C, Korth-Wiemann B, Krapivsky A, Kuenzler J, Kuntzsch A, Landers B, Lappo M, Laube S, Leggewie S, Lehmann D, Lepp H, Lierse T, Lindner C, Luecke-Uzar M, Luedemann J, Marschke T, Maruzzo S, Mauersberger K, Maus O, Meinrich M, Meissner A, Moehring B, Muehlhaus J, Mueller S, Muenter KC, Muenzel T, Naumann R, Nebel J, Neumann J, Nuding S, Overhoff U, Papke B, Pencz I, Peter Y, Peukert AM, Radde I, Rau T, Regner S, Reichenbach D, Reimer D, Rinke A, Roettges R, Romanski A, Rummel R, Samer H, Sanuri M, Sarnighausen HE, Schäfer B, Scheibner T, Schermaul KH, Schindler A, Schlundt C, Schmidt E, Schmidt K, Schnabel A, Schoen N, Schorn K, Schroeder T, Schulenburg D, Schulz M, Schulze U, Schulze J, Schumacher M, Schwerin G, Schwerin M, Stadelmeier S, Stahl HD, Stahl A, Stockhausen J, Stockhausen G, Stoessel J, Stolze K, Stratmann M, Szymanowski N, Teschner AB, Teske A, Uecker C, Veit S, Voeller H, Walter I, Walter J, Walther I, Weber HG, Weimer J, Wichterich K, Wiebusch A, Willmerdinger M, Willner C, Winkelmann B, Winkler J, Wistuba T, Woehrle J, Wohnlich T, Wolf S, Woyczak D, Wrage P, Zirlik A, Anadiotis A, Chachalis G, Dermitzakis A, Kafarakis P, Kaldara E, Kolokathis F, Kostakou P, Lekakis J, Manolis A, Mantas I, Megalou A, Milkas A, Nanas J, Olympios CD, Patsilinakos S, Perperis A, Poulimenos L, Saloustros I, Tsioufis K, Tsorbatzoglou K, Vardas P, Zarifis I, Aguilar M, Arango JL, Borrayo NA, Corona V, Guerrero A, Guzman I, Haase F, De Krumbach L, Montenegro P, Munoz R, Munoz N, Paniagua A, Solares A, Vogel M, Anita S, Blazsek Z, Decsi K, Fulop T, Hangyal T, Hegedus V, Kalina A, Karakai H, Katona A, Kiss RG, Kovacs A, Laszlo Z, Lupkovics G, Medvegy M, Merkely B, Mihaly N, Nagy AC, Dékány JN, Nikoletta P, Noori E, Penzes J, Poor F, Sarszegi Z, Simay A, Simon J, Szakal I, Szatmarine V, Szocs A, Zilahi Z, Karsai XZ, Andersen K, Sigurdadottir E, Skuladottir F, Abdullakutty J, Abhaichand R, Abhyankar A, Agarwal DK, Aggarwal RK, Ahire N, Awasthi AK, Babu R, Bai A, Bali HK, Banker D, Bhadade S, Bisne V, Bohra P, Raghu C, Chauhan D, Chauhan H, Chavada J, Chaware G, Chella S, Chintala P, Dash D, Desai D, Devasia T, Dhanak R, Dobariya H, Dudhatra N, Duhan S, Fulwani M, Ghondale N, Ghosh S, Gohel P, Govindaraj D, Goyal B, Goyal S, Gundala AK, Gupta M, Hardas S, Iby M, Jagtap P, Jain A, Joshi U, Karpuram M, Kaur H, Khan A, Khan R, Kodem DR, Koeitti P, Kulkarni L, Kullal P, Kumar KS, Kumbla M, Latheef K, Lohkare M, Santosh MJ, Makhe B, Mandati M, Mehta A, Minocha G, Mittal A, Modi R, Mohan K, Oomman A, Pai R, Pai V, Palaniswami N, Pansheriya A, Parekh N, Patel J, Patel R, Patole T, Praveen M, Radhakrishnan V, Rajan B A, Rajasekhar D, Rao M, Rao MB, Rao NM, Rathnavel S, Rathore A, Rathore SRS, Rawat S, Reddy NC, Sarma R, Sathe S, Shah J, Shaikh P, Sharma K, Sharma S, Sharma T, Shetty P, Sidhu G, Singh V, Sohi GS, Srinath VS, Raju SS, Taran A, Thakkar B, Velusamy K, Vijan V, Vora V, Vuriya AK, Agosta GF, Antonicelli R, Ardissino D, Argiolas G, Baldin MG, Benedetti G, Berti 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B, Mbulaiteye A, Mcalister R, Mccoy C, Mccrary D Jr, Mccullough-O'Brien H, Mcdonald M, Mcgill J, Mcgrew F, Mckenzie C, Mclaurin B, Mclellan BA, Mcneil D, Mcneill R, Mehrle A, Melbie K, Melliza T, Messina T, Meyer R, Michel K, Mikdadi G, Miller C, Miller R, Miller A, Miller G, Miller W, Mitchell J, Moats DJR, Mody F, Moffat J, Molk B, Molter D, Monroe T, Montero H, Montgomery R, Mookherjee D, Moran J, Moriarty P, Morrison J, Morton D, Moshayedi P, Mosley J, Moustafa M, Munshi K, Murray A, Mustafa J, Nadar V, Naidu R, Nalley J, Navy S, Neil L, Neutel JM, Niblack P, Nicely V, Nicolai M, Nijmeh G, Nikas A, Nikyar A, Nixon S, Norman L, Noto G, Nour K, Nugent A, Ocman B, Odegard A, Olsen S, Ortiz-Carrasquillo R, Ossino N, Paez H, Palchick B, Paliwal Y, Pannell R, Parfait V, Partridge J, Patel B, Patel R, Patel M, Patel S, Paysor C, Pena A, Pereira S, Perez M, Perez A, Perkins H, Perry B, Peters P, Phillippi C, Phillips A, Phillips A, Piacente R, Pintado M, Pish R, Pitt W, Poling T, Pomposini D, Poock J, Potts J, Poudrier R, Prior J, Pritchard C, Purighalla R, Quddusi K, Quinones J, Quinton D, Radin M, Radojcsics B, Rajput B, Rama B, Ramos M, Rauch R, Raynes K, Reber AM, Reddy J, Reeves M, Reilly K, Renaud K, Resnick H, Reyes R, Richardson M, Riethof M, Riser J, Rodero M, Rodriguez Araya E, Roper L, Rozeman P, Ruder D, Runquist L, Sack G, Saint-Jacques H, Salfity M, Sall N, Sam K, Samal A, Sanchez D, Santiago J Jr, Savignano C, Saylor R, Scheffel M, Schifferdecker B, Schindler E, Schneider P, Schneider R, Schnitzler R, Schrager B, Schwartz A, Scott R, Seals A, Shah AV, Shah A, Shatsky K, Shayani S, Shealy N, Sheets L, Shelley J, Shepard P, Shetty S, Silver K, Simon M, Singh K, Singh N, Sizemore BC, Skatrud L, Slayton C, Slimak V, Sloane G, Smallwood B, Smith P, Smith M, Smith T, Smith G, Smith B, Smith W, Smith M, Smith J, Smith J, Soca Y, Sofley C, Sopko K, Sosa-Padilla M, Sotolongo R, Sprinkle B, Srivastava S, Starzec M, Steinhoff J, Stelly L, Stinson J, Stoddard M, 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M., Everett, B. M., Thuren, T., Macfadyen, J. G., Chang, W. H., Ballantyne, C., FONSECA E PIRES, CARLOS EDUARDO, Nicolau, J., Koenig, W., Anker, S. D., Kastelein, J. J. P., Cornel, J. H., Pais, P., Pella, D., Genest, J., Cifkova, R., Lorenzatti, A., Forster, T., Kobalava, Z., Vida-Simiti, L., Flather, M., Shimokawa, H., Ogawa, H., Dellborg, M., Rossi, P. R. F., Troquay, R. P. T., Libby, P., Glynn R., J, CANTOS Trial, Group, Perrone, Filardi, P, ACS - Amsterdam Cardiovascular Sciences, Vascular Medicine, ACS - Pulmonary hypertension & thrombosis, and ACS - Atherosclerosis & ischemic syndromes
- Subjects
0301 basic medicine ,030204 cardiovascular system & hematology ,law.invention ,0302 clinical medicine ,c-reactive protein ,Randomized controlled trial ,law ,Cardiovascular Disease ,middle aged ,double-blind method ,antibodies ,Myocardial infarction ,humans ,Stroke ,interleukin-1beta ,biology ,Antibodies, Monoclonal ,drug ,General Medicine ,Lipid ,Aged ,anti-inflammatory agents ,monoclonal ,humanized ,atherosclerosis ,cardiovascular diseases ,dose-response relationship ,female ,incidence ,infections ,lipids ,male ,myocardial infarction ,neutropenia ,secondary prevention ,stroke ,Anti-Inflammatory Agent ,aged ,Editorial ,Atherosclerosi ,Monoclonal ,Human ,medicine.drug ,medicine.medical_specialty ,Neutropenia ,Antibodies, Monoclonal, Humanized ,Infections ,Placebo ,antibodies, monoclonal ,dose-response relationship, drug ,infection ,medicine (all) ,03 medical and health sciences ,Internal medicine ,medicine ,Dose-Response Relationship, Drug ,business.industry ,Antiinflammatory Therapy, Canakinumab, for Atherosclerotic Disease ,C-reactive protein ,medicine.disease ,Surgery ,Canakinumab ,030104 developmental biology ,biology.protein ,business - Abstract
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.)
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- 2017
18. Inflammatorische Angiogenesehemmung im kolorektalen Karzinom: Molekulare Mechanismen und prognostische Bedeutung
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Stürzl, M., Weinländer, K., Croner, R. S., Rau, T. T., Brückl, W. M., Hohenberger, W., Schellerer, V. S., Naschberger, E., Buhr, H. J., editor, Hölscher, A., editor, Izbicki, J. R., editor, Jauch, K. W., editor, Post, S., editor, Allgayer, H., editor, Bartsch, D. K., editor, Fries, H., editor, Ghadimi, B. M., editor, Habermann, J. K., editor, Kalthoff, H., editor, Schackert, H. K., editor, Bruns, C. J., editor, Duda, D. N., editor, Fändrich, F., editor, Heberer, M., editor, Nüssler, A. K., editor, Stark, G. B., editor, Brückner, U. B., editor, Ertel, W., editor, Faist, E., editor, Heidecke, C. D., editor, Kalff, J. C., editor, Menger, M. D., editor, Schade, U. F., editor, Vollmar, B., editor, Bechstein, W. O., editor, Klar, E., editor, Klempnauer, J., editor, Minor, T., editor, Neuhaus, P., editor, Schmidt, J., editor, Langer, S., editor, Laschke, M. W., editor, Machens, H. G., editor, Steinau, H. U., editor, Südkamp, N., editor, Vogt, P., editor, Berger, D., editor, Klinge, U., editor, Schachtrupp, A., editor, Schilling, M. K., editor, Schumpelick, V., editor, Altendorf-Hofmann, A., editor, Bollschweiler, E., editor, Bruch, H. -P., editor, Lehnert, T., editor, Lorenz, W., editor, Neugebauer, E., editor, Ohmann, C., editor, Seiler, C. M., editor, Becker, H., editor, Betzler, M., editor, Bittner, R., editor, Broelsch, C., editor, Büchler, M. W., editor, Bumm, R., editor, Dralle, H., editor, Friess, H., editor, Frilling, A., editor, Germer, C. T., editor, Hopt, U., editor, Jonas, S., editor, Jost, J., editor, Markus, B., editor, Raab, H. R., editor, Reith, H. B., editor, Schlag, P. M., editor, Teichmann, W., editor, Uhl, W., editor, Wenisch, H., editor, and Zornig, C., editor
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- 2009
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19. Geometrical aspect of solving the problem of real structure growth on the model of alkali metal halides of the NaCl type
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Rau, V. G., Pugaev, A. A., Rau, T. F., and Maleev, A. V.
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- 2009
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20. Assembly models for nanosized growth nuclei of crystal structures
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Rau, V. G., Pugaev, A. A., Rau, T. F., and Maleev, A. V.
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- 2009
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21. Pharmacogenetic characteristics of patients with complicated phenprocoumon dosing
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Werner, D., Werner, U., Wuerfel, A., Grosch, A., Lestin, H. G., Eschenhagen, T., and Rau, T.
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- 2009
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22. Geometrical aspect of the problem of model structure growth
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Rau, V. G., Bogatov, V. S., Rau, T. F., and Maleev, A. V.
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- 2009
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23. Zahlreiche Innovationen: Sind Sie up to date?: Pharmakologie
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Eschenhagen, Thomas and Rau, T.
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- 2008
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24. Preliminary time estimations using a novel and simple insertion tool for cochlear implant electrode arrays: observations toward clinical application
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Zuniga, M. Geraldine, additional, Lenarz, T, additional, and Rau, T, additional
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- 2021
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25. Do K-wires made from shape memory alloys increase pull-out forces? A preliminary experimental cadaver study in bovine bone
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Wiebking, U., Gösling, T., Monschizada, W., Rau, T., and Krettek, C.
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- 2007
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26. Aldosteron und Aldosteronrezeptorantagonisten in der Herzinsuffizienztherapie
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Rau, T. and Eschenhagen, T.
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- 2007
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27. Atraumatische Elektrodeninsertion der Zukunft
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Lenarz, T, Salcher, R, Prenzler, N, and Rau, T
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ddc: 610 ,610 Medical sciences ,Medicine - Abstract
Eine Hörerhaltung im Rahmen der Cochlea-Implantation ist heute bei einer großen Zahl der Patienten mit ausreichendem Restgehör möglich. Es zeigen ca. 70% der Patienten eine gute Erhaltung des Restgehörs (kleiner gleich 15 dB Hörschwellenverlust prä-/postoperativ).[zum vollständigen Text gelangen Sie über die oben angegebene URL], 23. Jahrestagung der Deutschen Gesellschaft für Audiologie
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- 2020
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28. Assessment of a Fuel Cell Powered Full Electric Subsystem Architecture for the Avacon Research Baseline Aircraft
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van Wensveen, J., Peter, F., Rau, T., and Hornung, M.
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fuel cell ,sub-systems - Abstract
powering a full electric subsystem architecture and replacing the conventional auxiliary power unit. The electrical subsystems power load calculations and the component sizing of the fuel cell system are performed with a mix of statistical, semi-empirical, and semi-analytical methods within the tool eFLOWpy. A 2% operational empty mass increase is assumed to account for the subsystem electrification mass change. The fuel cell system considered consists of six fuel cell stacks, a liquid hydrogen storage tank, a compressor to provide cabin air and a cooling loop with heat exchanger. The mass and volume of the fuel cell system is calculated on a main component basis. The overall sizing and analysis considers a standard mission trajectory including diversion. The results show a kerosene block fuel reduction of 1.2% compared to the AVACON research baseline aircraft with conventional subsystems, while further fuel cell system optimisation could potentially lead to a 3% reduction.
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- 2020
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29. Arterial stroke as an isolated manifestation of homocystinuria in an infant
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Mahale, Rohan, Mehta, Anish, Rau, T., Acharya, Purushottam, and Srinivasa, Rangasetty
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Health - Abstract
Byline: Rohan. Mahale, Anish. Mehta, T. Rau, Purushottam. Acharya, Rangasetty. Srinivasa Dear Sir, Pediatric stroke has remained an under-recognized nosological entity among pediatricians.[sup][1] The incidence of pediatric stroke is 1–6 [...]
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- 2017
30. Coordination sequences and coordination waves in matter
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Rau, V. G., Pugaev, A. A., and Rau, T. F.
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- 2006
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31. Discrete modeling of homometric and isovector divisions
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Rau, V. G. and Rau, T. F.
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- 2003
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32. Morphogenesis of crystal structures in the discrete modeling of packings
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Rau, V. G., Zhuravlev, V. G., Rau, T. F., and Maleev, A. V.
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- 2002
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33. 24-h Langendorff-perfused neonatal rat heart used to study the impact of adenoviral gene transfer
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Wiechert, S., El-Armouche, A., Rau, T., Zimmermann, W.-H, and Eschenhagen, T.
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Heart failure -- Research ,Genomics -- Research ,Biological sciences - Abstract
The human genome project has increased the demand for simple experimental systems that allow the impact of gene manipulations to be studied under controlled ex vivo conditions. We hypothesized that, in contrast to adult hearts, neonatal hearts allow long-term perfusion and efficient gene transfer ex vivo. A Langendorff perfusion system was modified to allow perfusion for >24 h with particular emphasis on uncompromised contractile activity, sterility, online measurement of force of contraction, inotropic response to [beta]-adrenergic stimulation, and efficient gene transfer. The hearts were perfused with serum-free medium (DMEM + medium 199, 4 + 1) supplemented with hydrocortisone, triiodothyronine, ascorbic acid, insulin, pyruvate, L-carnitine, creatine, taurine, L-glutamine, mannitol, and antibiotics recirculating (500 ml/2 hearts) at 1 ml/min. Hearts from 2 day-old rats beat constantly at 135-155 beats/ min and developed active force of 1-2 mN. During 24 h of perfusion, twitch tension increased to ~165% of initial values (P < 0.05), whereas the inotropic response to isoprenaline remained constant. A decrease in total protein content of 10% and histological examination indicated moderate edema, but actin and calsequestrin concentration remained unchanged and perfusion pressure remained constant at 7-11 mmHg. Perfusion with a LacZ-encoding adenovirus at 3 x [10.sup.8] active virus particles yielded homogeneous transfection of ~80% throughout the heart and did not affect heart rate, force of contraction, or response to isoprenaline compared with uninfected controls (n = 7 each). Taken together, the 24-h Langendorff-perfused neonatal rat heart is a relatively simple, inexpensive, and robust new heart model that appears feasible as a test bed for functional genomics. functional genomics; heart failure; molecular biology
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- 2003
34. Geometrical model of the structure of the heterocomplex compound [Cr(OCN2H4)6]3+[Co(DH)2(NO2)2]3− ⋅ 2H2O
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Rau, V. G., Rau, T. F., Lebedev, G. O., and Kurkutova, E. N.
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- 2000
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35. Inflammation-associated inhibition of angiogenesis in colorectal carcinoma: molecular mechanisms and prognostic impact
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Stürzl, M., primary, Weinländer, K., additional, Croner, R. S., additional, Rau, T. T., additional, Brückl, W. M., additional, Hohenberger, W., additional, Schellerer, V. S., additional, and Naschberger, E., additional
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- 2009
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36. ACCEPTANCE ANALYSIS AND PILOT TESTING OF A NEW ELECTRONIC BLOOD DONOR ID-CARD AT GERMAN RED CROSS BLOOD DONATION SERVICES: 5D-S46–03
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Knels, R, Gräulich, N, Rau, T, Gillert, F, and Stangenberg, W
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- 2012
37. Pathological work-up after neoadjuvant treatment in rectal carcinoma: An interlaboratory test measuring interobserver agreement in assessing tumor regression grade: PO121
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Oberschmid, B., Rau, T., and Wittekind, C.
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- 2010
38. Pluripotent parthenogenetic stem cells with a cardiogenic potential can be generated to express heterozygous and homozygous major histocompatibility complexes
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Didie, M, Christalla, P, Rau, T, Eschenhagen, T, Schumacher, U, Lin, Q, Zenke, M, and Zimmmermann, WH
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- 2010
39. INFLUENCE OF CYCLOOXYGENASE INHIBITORS ON THE FUNCTION OF THE PROSTAGLANDIN TRANSPORTER OATP2A1 EXPRESSED IN HUMAN GASTRIC MUCOSA: 55
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Mandery, K., Bujok, K., Schmidt, I., Rau, T. T., Fromm, M. F., and Glaeser, H.
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- 2009
40. Impact of the CYP2D6 Genotype on the Clinical Effects of Metoprolol: A Prospective Longitudinal Study
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Rau, T, Wuttke, H, Michels, L M, Werner, U, Bergmann, K, Kreft, M, Fromm, M F, and Eschenhagen, T
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- 2009
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41. Plexiform angiomyxoid myofibroblastic tumour: differential diagnosis of gastrointestinal stromal tumour in the stomach
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Rau, T T, Hartmann, A, Dietmaier, W, Schmitz, J, Hohenberger, W, Hofstaedter, F, and Katenkamp, K
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- 2008
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42. Enhanced expression of CTLA-4 (CD152) on CD4+ T cells in HIV infection
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STEINER, K., WAASE, I., RAU, T., DIETRICH, M., FLEISCHER, B., and BRÖKER, B. M.
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- 1999
43. On the way to minimally-invasive cochlear implantation: First results of a cadaver study
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Timm, M, additional, Stieghorst, J, additional, Kluge, M, additional, John, S, additional, Rau, T, additional, and Lenarz, T, additional
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- 2019
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44. Auf dem Weg zur minimal-invasiven Cochlea Implantation: Erste Ergebnisse einer Kadaverstudie
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Timm, M, additional, Stieghorst, J, additional, Kluge, M, additional, John, S, additional, Rau, T, additional, and Lenarz, T, additional
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- 2019
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45. WPSIII-3 Screening of traditional Chinese medicinal plants with antiviral potential.
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Rau, T, primary and Liu, J, additional
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- 2018
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46. Diagnostic challenge of atypical colorectal metastasis to the renal pelvis
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Bastian, Keck, Tilman, Rau T., Frens, Krause S., Bernhardt, Walter, Peter, Goebell J., Arndt, Hartmann, and Bernd, Wullich
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- 2011
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47. Antibiotic treatment of chronic endometritis seems to preserve pregnancy in women with recurrent miscarriages or recurrent implantation failure
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Meier, S, additional, Gillon, T, additional, Mitter, V, additional, Fink, A, additional, Mueller, M, additional, Rau, T, additional, Von Wolff, M, additional, and Kohl Schwartz, A, additional
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- 2018
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48. Klinische Beurteilung der Positioniergenauigkeit des RoboJig-Systems durch Vergleich mit anatomischen und chirurgischen Randbedingungen
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Majdani, O, additional, Kluge, M, additional, Kreul, D, additional, Lexow, J, additional, Lenarz, T, additional, and Rau, T, additional
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- 2018
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49. BDNF-producing human mesenchymal stem cells in an alginate-matrix: neuroprotection and cochlear implant coating stability in vitro
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Schwieger, J, additional, Hügl, S, additional, Hamm, A, additional, Lenarz, T, additional, Hoffmann, A, additional, Rau, T, additional, and Scheper, V, additional
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- 2018
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50. BDNF-produzierende humane mesenchymale Stammzellen in Alginat-Matrix: Neuroprotektion und Stabilität einer Cochlea-Implantat-Beschichtung in vitro
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Schwieger, J, additional, Hügl, S, additional, Hamm, A, additional, Lenarz, T, additional, Hoffmann, A, additional, Rau, T, additional, and Scheper, V, additional
- Published
- 2018
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