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1. Daring to Feel: Emotion-Focused Psychotherapy Increases Amygdala Activation and Connectivity in Euthymic Bipolar Disorder—A Randomized Controlled Trial

Author

Meyer, Kristina, Hindi Attar, Catherine, Fiebig, Jana, Stamm, Thomas, Bassett, Tyler R., Bauer, Michael, Dannlowski, Udo, Ethofer, Thomas, Falkenberg, Irina, Jansen, Andreas, Juckel, Georg, Kircher, Tilo, Mulert, Christoph, Leicht, Gregor, Rau, Anne, Rauh, Jonas, Ritter, Dirk, Ritter, Philipp, Trost, Sarah, Vogelbacher, Christoph, Walter, Henrik, Wolter, Sarah, Hautzinger, Martin, and Bermpohl, Felix

Published
2023
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2. Boosting the Theory of Mind Network: Specific Psychotherapy Increases Neural Correlates of Affective Theory of Mind in Euthymic Bipolar Disorder

Author

Meyer, Kristina, Hindi Attar, Catherine, Fiebig, Jana, Stamm, Thomas, Bassett, Tyler R., Bauer, Michael, Dannlowski, Udo, Ethofer, Thomas, Falkenberg, Irina, Jansen, Andreas, Juckel, Georg, Kircher, Tilo, Mulert, Christoph, Leicht, Gregor, Rau, Anne, Ritter, Dirk, Ritter, Philipp, Trost, Sarah, Vogelbacher, Christoph, Walter, Henrik, Wolter, Sarah, Hautzinger, Martin, and Bermpohl, Felix

Published
2023
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3. Individuals at increased risk for development of bipolar disorder display structural alterations similar to people with manifest disease

Author

Mikolas, Pavol, Bröckel, Kyra, Vogelbacher, Christoph, Müller, Dirk K., Marxen, Michael, Berndt, Christina, Sauer, Cathrin, Jung, Stine, Fröhner, Juliane Hilde, Fallgatter, Andreas J., Ethofer, Thomas, Rau, Anne, Kircher, Tilo, Falkenberg, Irina, Lambert, Martin, Kraft, Vivien, Leopold, Karolina, Bechdolf, Andreas, Reif, Andreas, Matura, Silke, Stamm, Thomas, Bermpohl, Felix, Fiebig, Jana, Juckel, Georg, Flasbeck, Vera, Correll, Christoph U., Ritter, Philipp, Bauer, Michael, Jansen, Andreas, and Pfennig, Andrea

Published
2021
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5. Prediction of estimated risk for bipolar disorder using machine learning and structural MRI features.

Author

Mikolas, Pavol, Marxen, Michael, Riedel, Philipp, Bröckel, Kyra, Martini, Julia, Huth, Fabian, Berndt, Christina, Vogelbacher, Christoph, Jansen, Andreas, Kircher, Tilo, Falkenberg, Irina, Lambert, Martin, Kraft, Vivien, Leicht, Gregor, Mulert, Christoph, Fallgatter, Andreas J., Ethofer, Thomas, Rau, Anne, Leopold, Karolina, and Bechdolf, Andreas

Subjects
BIPOLAR disorder, RISK assessment, RECOGNITION (Psychology), BRAIN, MAGNETIC resonance imaging, HELP-seeking behavior, DESCRIPTIVE statistics, SUPPORT vector machines, RESEARCH, MACHINE learning, BRAIN cortical thickness, COMPARATIVE studies, CONFIDENCE intervals, ECONOMIC aspects of diseases, BRAIN mapping
Abstract

Background: Individuals with bipolar disorder are commonly correctly diagnosed a decade after symptom onset. Machine learning techniques may aid in early recognition and reduce the disease burden. As both individuals at risk and those with a manifest disease display structural brain markers, structural magnetic resonance imaging may provide relevant classification features. Methods: Following a pre-registered protocol, we trained linear support vector machine (SVM) to classify individuals according to their estimated risk for bipolar disorder using regional cortical thickness of help-seeking individuals from seven study sites (N = 276). We estimated the risk using three state-of-the-art assessment instruments (BPSS-P, BARS, EPI bipolar). Results: For BPSS-P, SVM achieved a fair performance of Cohen's κ of 0.235 (95% CI 0.11–0.361) and a balanced accuracy of 63.1% (95% CI 55.9–70.3) in the 10-fold cross-validation. In the leave-one-site-out cross-validation, the model performed with a Cohen's κ of 0.128 (95% CI −0.069 to 0.325) and a balanced accuracy of 56.2% (95% CI 44.6–67.8). BARS and EPI bipolar could not be predicted. In post hoc analyses, regional surface area, subcortical volumes as well as hyperparameter optimization did not improve the performance. Conclusions: Individuals at risk for bipolar disorder, as assessed by BPSS-P, display brain structural alterations that can be detected using machine learning. The achieved performance is comparable to previous studies which attempted to classify patients with manifest disease and healthy controls. Unlike previous studies of bipolar risk, our multicenter design permitted a leave-one-site-out cross-validation. Whole-brain cortical thickness seems to be superior to other structural brain features. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Same Same, but Different: Word and Sentence Reading in German and English

Author

Rau, Anne K., Moll, Kristina, Moeller, Korbinian, Huber, Stefan, Snowling, Margaret J., and Landerl, Karin

Abstract

The current study compared eye fixation patterns during word and sentence processing in a consistent and an inconsistent alphabetic orthography. German and English children as well as adults matched on word reading ability read matched sentences while their eye fixation behavior was recorded. Results indicated that German children read in a more small-unit plodder-like style with more diligent first-pass reading and less rereading. In contrast, English children read in a more large-unit explorer-like style with a greater tendency to skip words, and more regressions. It is important that these cross-linguistic processing differences largely persisted in the adult readers. Orthographic consistency thus influences both local word recognition and global sentence processing in developing and skilled readers.

Published
2016
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7. Machine Learning Prediction of Estimated Risk for Bipolar Disorders Using Hippocampal Subfield and Amygdala Nuclei Volumes

Author

Huth, Fabian, primary, Tozzi, Leonardo, additional, Marxen, Michael, additional, Riedel, Philipp, additional, Bröckel, Kyra, additional, Martini, Julia, additional, Berndt, Christina, additional, Sauer, Cathrin, additional, Vogelbacher, Christoph, additional, Jansen, Andreas, additional, Kircher, Tilo, additional, Falkenberg, Irina, additional, Thomas-Odenthal, Florian, additional, Lambert, Martin, additional, Kraft, Vivien, additional, Leicht, Gregor, additional, Mulert, Christoph, additional, Fallgatter, Andreas J., additional, Ethofer, Thomas, additional, Rau, Anne, additional, Leopold, Karolina, additional, Bechdolf, Andreas, additional, Reif, Andreas, additional, Matura, Silke, additional, Biere, Silvia, additional, Bermpohl, Felix, additional, Fiebig, Jana, additional, Stamm, Thomas, additional, Correll, Christoph U., additional, Juckel, Georg, additional, Flasbeck, Vera, additional, Ritter, Philipp, additional, Bauer, Michael, additional, Pfennig, Andrea, additional, and Mikolas, Pavol, additional

Published
2023
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8. Prediction of estimated risk for bipolar disorder using machine learning and structural MRI features

Author

Mikolas, Pavol, primary, Marxen, Michael, additional, Riedel, Philipp, additional, Bröckel, Kyra, additional, Martini, Julia, additional, Huth, Fabian, additional, Berndt, Christina, additional, Vogelbacher, Christoph, additional, Jansen, Andreas, additional, Kircher, Tilo, additional, Falkenberg, Irina, additional, Lambert, Martin, additional, Kraft, Vivien, additional, Leicht, Gregor, additional, Mulert, Christoph, additional, Fallgatter, Andreas J., additional, Ethofer, Thomas, additional, Rau, Anne, additional, Leopold, Karolina, additional, Bechdolf, Andreas, additional, Reif, Andreas, additional, Matura, Silke, additional, Bermpohl, Felix, additional, Fiebig, Jana, additional, Stamm, Thomas, additional, Correll, Christoph U., additional, Juckel, Georg, additional, Flasbeck, Vera, additional, Ritter, Philipp, additional, Bauer, Michael, additional, and Pfennig, Andrea, additional

Published
2023
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10. Daring to feel: Emotion-focused psychotherapy increases amygdala activation and connectivity in euthymic bipolar disorder

Author

Meyer, Kristina, primary, Attar, Catherine Hindi, additional, Fiebig, Jana, additional, Stamm, Thomas, additional, Bassett, Tyler R., additional, Bauer, Michael, additional, Dannlowski, Udo, additional, Ethofer, Thomas, additional, Falkenberg, Irina, additional, Jansen, Andreas, additional, Juckel, Georg, additional, Kircher, Tilo, additional, Mulert, Christoph, additional, Leicht, Gregor, additional, Rau, Anne, additional, Rauh, Jonas, additional, Ritter, Dirk, additional, Ritter, Philipp, additional, Trost, Sarah, additional, Vogelbacher, Christoph, additional, Walter, Henrik, additional, Wolter, Sarah, additional, and Hautzinger, Martin, additional

Published
2022
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11. Boosting the Theory of Mind Network: Specific Psychotherapy Increases Neural Correlates of Affective Theory of Mind in Euthymic Bipolar Disorder

Author

Meyer, Kristina, primary, Hindi Attar, Catherine, additional, Fiebig, Jana, additional, Stamm, Thomas, additional, Bassett, Tyler R., additional, Bauer, Michael, additional, Dannlowski, Udo, additional, Ethofer, Thomas, additional, Falkenberg, Irina, additional, Jansen, Andreas, additional, Juckel, Georg, additional, Kircher, Tilo, additional, Mulert, Christoph, additional, Leicht, Gregor, additional, Rau, Anne, additional, Ritter, Dirk, additional, Ritter, Philipp, additional, Trost, Sarah, additional, Vogelbacher, Christoph, additional, Walter, Henrik, additional, Wolter, Sarah, additional, Hautzinger, Martin, additional, and Bermpohl, Felix, additional

Published
2022
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12. Prediction of estimated risk for bipolar disorder using machine learning and structural MRI features

Author

Mikolas, Pavol, primary, Marxen, Michael, additional, Riedel, Philipp, additional, Bröckel, Kyra, additional, Martini, Julia, additional, Huth, Fabian, additional, Berndt, Christina, additional, Vogelbacher, Christoph, additional, Jansesn, Andreas, additional, Kircher, Tilo, additional, Falkenberg, Irina, additional, Lambert, Martin, additional, Kraft, Vivien, additional, Leicht, Gregor, additional, Mulert, Christoph, additional, Fallgatter, Andreas, additional, Ethofer, Thomas, additional, Rau, Anne, additional, Leopold, Karolina, additional, Bechdolf, Andreas, additional, Reif, Andreas, additional, Matura, Silke, additional, Bermpohl, Felix, additional, Fiebig, Jana, additional, Stamm, Thomas, additional, Correll, Christoph, additional, Juckel, Georg, additional, Flasbeck, Vera, additional, ritter, philipp, additional, Bauer, Michael, additional, and Pfennig, Andrea, additional

Published
2022
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13. Boosting the ToM network: Specific psychotherapy increases neural correlates of affective theory of mind in euthymic bipolar disorder

Author

Meyer, Kristina, primary, Attar, Catherine Hindi, additional, Fiebig, Jana, additional, Stamm, Thomas, additional, Bassett, Tyler R., additional, Bauer, Michael, additional, Dannlowski, Udo, additional, Ethofer, Thomas, additional, Falkenberg, Irina, additional, Jansen, Andreas, additional, Juckel, Georg, additional, Kircher, Tilo, additional, Mulert, Christoph, additional, Leicht, Gregor, additional, Rau, Anne, additional, Ritter, Dirk, additional, Ritter, Philipp, additional, Trost, Sarah, additional, Vogelbacher, Christoph, additional, Walter, Henrik, additional, Wolter, Sarah, additional, Hautzinger, Martin, additional, and Bermpohl, Felix, additional

Published
2021
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14. Comparison and evaluation of methods for liver segmentation from CT datasets

Author

Heimann, Tobias, van Ginneken, Bram, Styner, Martin A., Arzhaeva, Yulia, Aurich, Volker, Bauer, Christian, Beck, Andreas, Becker, Christoph, Beichel, Reinhard, Bekes, Gyorgy, Bello, Fernando, Binnig, Gerd, Bischof, Horst, Bornik, Alexander, Cashman, Peter M.M., Chi, Ying, Cordova, Andres, Dawant, Benoit M., Fidrich, Marta, Furst, Jacob D., Furukawa, Daisuke, Grenacher, Lars, Hornegger, Joachim, Kainmuller, Dagmar, Kitney, Richard I., Kobatake, Hidefumi, Lamecker, Hans, Lange, Thomas, Lee, Jeongjin, Lennon, Brian, Li, Rui, Li, Senhu, Meinzer, Hans-Peter, Nemeth, Gabor, Raicu, Daniela S., Rau, Anne-Mareike, van Rikxoort, Eva M., Rousson, Mikael, Rusko, Laszlo, Saddi, Kinda A., Schmidt, Gunter, Seghers, Dieter, Shimizu, Akinobu, Slagmolen, Pieter, Sorantin, Erich, Soza, Grzegorz, Susomboon, Ruchaneewan, Waite, Jonathan M., Wimmer, Andreas, and Wolf, Ivo

Subjects
Algorithms -- Research, CT imaging -- Research, Liver -- Medical examination, Algorithm, Business, Electronics, Electronics and electrical industries, Health care industry
Published
2009

16. The Influence of Orthographic Consistency on Eye Movement Behaviour in Word and Sentence Processing

Author

Rau, Anne Katrin and Landerl, Karin (Prof. Dr.)

Subjects
Blickbewegungen, Wortverarbeitung, orthographic consistency, orthografische Konsistenz, Worthäufigkeitseffekt, word recognition, sentence processing, cross-linguistic, eye tracking, word length effect, eye movements, word processing, Wortlängeneffekt, word frequency effect, Satzverarbeitung, Leseforschung , Blickbewegung
Abstract

In reading science, studies carried out with English-speaking participants reading in their native language have traditionally formed the basis for most theories and models. From the 1990s, however, there was a continuously growing conviction that this English-based research agenda alone would not lead to a universal science of reading. A major reason why English is not a good basis for developing univerally applicable theories and models on reading and reading acquisition is that the English orthography is exceptionally inconsistent with regards to the relationship of letters and sounds (low grapheme-phoneme consistency). One consequence of this inconsistency is that for reading English linguistic processing rather relies on small lingusitic units, whereas for more consistent languages (such as German) large linguistic units are rather relied upon. (Psycholinguistic grain size theory (Ziegler & Goswami, 2005)) – for example ultimately leading to a relative delay regarding reading acquisition skills for children learning English. The research project presented here set out to deepen and broaden the understanding of this phenomenon. In three studies, both word processing and sentence processing in the consistent German and the inconsistent English orthography were investigated. Methodologically, I studied eye movement behaviour in both developing readers and adult readers. The studies reported here support the central claim of grain size theory. Study one investigated the transition in predominant reading strategy from serial sublexical decoding to more parallel lexical processing as a function of word frequency in the consistent German orthography. The least experienced readers of grade 2 were found to apply serial sublexical decoding as a default reading strategy to most items, largely independent of word frequency, whereas more experienced readers of grades 3 and 4, and adults, were increasingly relying on direct lexical access. Studies two and three investigated the influence of orthographic consistency on the time-course of word and sentence processing; now focusing on a cross-linguistic comparison. The two studies found evidence for more small-unit bottom-up processing on the part of the German, and more large-unit top-down processing on the part of the English readers, for both the local word level, and the global sentence level. The overall processing pattern differed between orthographies: while German readers showed a plodder-like reading style with more diligent first-pass reading and less re-reading, English readers showed an explorer-like reading style with more word skippings and more regressive eye movements. In sum, orthographic consistency impacts upon both local word recognition and global sentence processing, in both developing and skilled readers.

Published
2015

24. The Transition From Sublexical to Lexical Processing in a Consistent Orthography: An Eye-Tracking Study.

Author

Rau, Anne K., Moeller, Korbinian, and Landerl, Karin

Subjects
*LEXICAL access, *ORTHOGRAPHY & spelling, *READING strategies, *CHILDREN, *WORD recognition, *LEARNING strategies
Abstract

We studied the transition in predominant reading strategy from serial sublexical processing to more parallel lexical processing as a function of word familiarity in German children of Grades 2, 3, 4, and adults. High-frequency words, low-frequency words, and nonwords of differing length were embedded in sentences and presented in an eye-tracking paradigm. The size of the word length effect was used as an indicator of serial sublexical decoding. When controlling for the generally higher processing times in younger readers, the effect of length over reading development was not direct but modulated by familiarity: Length effects were comparable between items of differing familiarity for Grade 2, whereas from Grade 3, length effects increased with decreasing familiarity. These findings suggest that Grade 2 children apply serial sublexical decoding as a default reading strategy to most items, whereas reading by direct lexical access is increasingly dominant in more experienced readers. [ABSTRACT FROM PUBLISHER]

Published
2014
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