Search

Your search keyword '"Ratti, F"' showing total 1,018 results
Start Over Author "Ratti, F"
1,018 results on '"Ratti, F"'

1. Architecture of TOI-561 planetary system

Author

Piotto, G., Zingales, T., Borsato, L., Egger, J. A., Correia, A. C. M., Simon, A. E., Florén, H. G., Sousa, S. G., Maxted, P. F. L., Nardiello, D., Malavolta, L., Wilson, T. G., Alibert, Y., Adibekyan, V., Bonfanti, A., Luque, R., Santos, N. C., Hooton, M. J., Fossati, L., Smith, A. M. S., Salmon, S., Lacedelli, G., Alonso, R., Bárczy, T., Navascues, D. Barrado, Barros, S. C. C., Baumjohann, W., Beck, T., Benz, W., Billot, N., Brandeker, A., Broeg, C., Buder, M., Cameron, A. Collier, Csizmadia, Sz., Cubillos, P. E., Davies, M. B., Deleuil, M., Deline, A., Demangeon, O. D. S., Demory, B. O., Derekas, A., Edwards, B., Ehrenreich, D., Erikson, A., Fortier, A., Fridlund, M., Gandolfi, D., Gazeas, K., Gillon, M., Güdel, M., Günther, M. N., Heitzmann, A., Helling, Ch., Isaak, K. G., Kiss, L. L., Korth, J., Lam, K. W. F., Laskar, J., Etangs, A. Lecavelier des, Lendl, M., Leonardi, P., Magrin, D., Mantovan, G., Mordasini, C., Nascimbeni, V., Olofsson, G., Ottensamer, R., Pagano, I., Pallé, E., Peter, G., Pollacco, D., Queloz, D., Ragazzoni, R., Rando, N., Ratti, F., Rauer, H., Ribas, I., Scandariato, G., Ségransan, D., Sicilia, D., Stalport, M., Sulis, S., Szabó, Gy. M., Udry, S., Ulmer-Moll, S., Van Grootel, V., Venturini, J., Villaver, E., Walton, N. A., Winn, J. N., and Wolf, S.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

We present new observations from CHEOPS and TESS to clarify the architecture of the planetary system hosted by the old Galactic thick disk star TOI-561. Our global analysis, which also includes previously published photometric and radial velocity data, incontrovertibly proves that TOI-561 is hosting at least four transiting planets with periods of 0.44 days (TOI-561 b), 10.8 days (TOI-561 c), 25.7 days (TOI-561 d), and 77.1 days (TOI-561 e) and a fifth non-transiting candidate, TOI-561f with a period of 433 days. The precise characterisation of TOI-561's orbital architecture is interesting since old and metal-poor thick disk stars are less likely to host ultra-short period Super-Earths like TOI-561 b. The new period of planet -e is consistent with the value obtained using radial velocity alone and is now known to be $77.14399\pm0.00025$ days, thanks to the new CHEOPS and TESS transits. The new data allowed us to improve its radius ($R_p = 2.517 \pm 0.045 R_{\oplus}$ from 5$\%$ to 2$\%$ precision) and mass ($M_p = 12.4 \pm 1.4 M_{\oplus}$) estimates, implying a density of $\rho_p = 0.778 \pm 0.097 \rho_{\oplus}$. Thanks to recent TESS observations and the focused CHEOPS visit of the transit of TOI-561 e, a good candidate for exomoon searches, the planet's period is finally constrained, allowing us to predict transit times through 2030 with 20-minute accuracy. We present an updated version of the internal structure of the four transiting planets. We finally performed a detailed stability analysis, which confirmed the long-term stability of the outer planet TOI-561 f., Comment: 13 pages, 10 Figures. Accepted on MNRAS. Updated the author list

Published
2024

2. Characterisation of the Warm-Jupiter TOI-1130 system with CHEOPS and photo-dynamical approach

Author

Borsato, L., Degen, D., Leleu, A., Hooton, M. J., Egger, J. A., Bekkelien, A., Brandeker, A., Cameron, A. Collier, Günther, M. N., Nascimbeni, V., Persson, C. M., Bonfanti, A., Wilson, T. G., Correia, A. C. M., Zingales, T., Guillot, T., Triaud, A. H. M. J., Piotto, G., Gandolfi, D., Abe, L., Alibert, Y., Alonso, R., Bárczy, T., Navascues, D. Barrado, Barros, S. C. C., Baumjohann, W., Beck, T., Bendjoya, P., Benz, W., Billot, N., Broeg, C., Busch, M. -D., Csizmadia, Sz., Cubillos, P. E., Davies, M. B., Deleuil, M., Deline, A., Delrez, L., Demangeon, O. D. S., Demory, B. -O., Derekas, A., Edwards, B., Ehrenreich, D., Erikson, A., Fortier, A., Fossati, L., Fridlund, M., Gazeas, K., Gillon, M., Güdel, M., Heitzmann, A., Helling, Ch., Hoyer, S., Isaak, K. G., Kiss, L. L., Korth, J., Lam, K. W. F., Laskar, J., Etangs, A. Lecavelier des, Lendl, M., Magrin, D., Marafatto, L., Maxted, P. F. L., Mecina, M., Mékarnia, D., Mordasini, C., Mura, D., Olofsson, G., Ottensamer, R., Pagano, I., Pallé, E., Peter, G., Pollacco, D., Queloz, D., Ragazzoni, R., Rando, N., Ratti, F., Rauer, H., Ribas, I., Salmon, S., Santos, N. C., Scandariato, G., Ségransan, D., Simon, A. E., Smith, A. M. S., Sousa, S. G., Stalport, M., Suarez, O., Sulis, S., Szabó, Gy. M., Udry, S., Van Grootel, V., Venturini, J., Villaver, E., Walton, N. A., and Wolter, D.

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract

Among the thousands of exoplanets discovered to date, approximately a few hundred gas giants on short-period orbits are classified as "lonely" and only a few are in a multi-planet system with a smaller companion on a close orbit. The processes that formed multi-planet systems hosting gas giants on close orbits are poorly understood, and only a few examples of this kind of system have been observed and well characterised. Within the contest of multi-planet system hosting gas-giant on short orbits, we characterise TOI-1130 system by measuring masses and orbital parameters. This is a 2-transiting planet system with a Jupiter-like planet (c) on a 8.35 days orbit and a Neptune-like planet (b) on an inner (4.07 days) orbit. Both planets show strong anti-correlated transit timing variations (TTVs). Furthermore, radial velocity (RV) analysis showed an additional linear trend, a possible hint of a non-transiting candidate planet on a far outer orbit. Since 2019, extensive transit and radial velocity observations of the TOI-1130 have been acquired using TESS and various ground-based facilities. We present a new photo-dynamical analysis of all available transit and RV data, with the addition of new CHEOPS and ASTEP+ data that achieve the best precision to date on the planetary radii and masses and on the timings of each transit. We were able to model interior structure of planet b constraining the presence of a gaseous envelope of H/He, while it was not possible to assess the possible water content. Furthermore, we analysed the resonant state of the two transiting planets, and we found that they lie just outside the resonant region. This could be the result of the tidal evolution that the system underwent. We obtained both masses of the planets with a precision less than 1.5%, and radii with a precision of about 1% and 3% for planet b and c, respectively., Comment: 22 pages, 10 figures, Accepted for publication by Astronomy and Astrophysics

Published
2024
Full Text
View/download PDF

3. Detailed cool star flare morphology with CHEOPS and TESS

Author

Bruno, G., Pagano, I., Scandariato, G., Florén, H. -G., Brandeker, A., Olofsson, G., Maxted, P. F. L., Fortier, A., Sousa, S. G., Sulis, S., Van Grootel, V., Garai, Z., Boldog, A., Kriskovics, L., Szabó, M. Gy., Gandolfi, D., Alibert, Y., Alonso, R., Bárczy, T., Navascues, D. Barrado, Barros, S. C. C., Baumjohann, W., Beck, M., Beck, T., Benz, W., Billot, N., Borsato, L., Broeg, C., Cameron, A. Collier, Csizmadia, Sz., Cubillos, P. E., Davies, M. B., Deleuil, M., Deline, A., Delrez, L., Demangeon, O. D. S., Demory, B. -O., Ehrenreich, D., Erikson, A., Farinato, J., Fossati, L., Fridlund, M., Gillon, M., Güdel, M., Günther, M. N., Heitzmann, A., Helling, Ch., Hoyer, S., Isaak, K. G., Kiss, L., Lam, K. W. F., Laskar, J., Etangs, A. Lecavelier des, Lendl, M., Magrin, D., Mordasini, C., Nascimbeni, V., Ottensamer, R., Pallé, E., Peter, G., Piotto, G., Pollacco, D., Queloz, D., Ragazzoni, R., Rando, N., Ratti, F., Rauer, H., Ribas, I., Santos, N. C., Sarajlic, M., Ségransan, D., Simon, A. E., Singh, V., Smith, A. M. S., Stalport, M., Thomas, N., Udry, S., Ulmer, B., Venturini, J., Villaver, E., Walton, N. A., and Wilson, T. G.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Earth and Planetary Astrophysics
Abstract

Context. White-light stellar flares are proxies for some of the most energetic types of flares, but their triggering mechanism is still poorly understood. As they are associated with strong X and UV emission, their study is particularly relevant to estimate the amount of high-energy irradiation onto the atmospheres of exoplanets, especially those in their stars' habitable zone. Aims. We used the high-cadence, high-photometric capabilities of the CHEOPS and TESS space telescopes to study the detailed morphology of white-light flares occurring in a sample of 130 late-K and M stars, and compared our findings with results obtained at a lower cadence. We developed dedicated software for this purpose. Results. Multi-peak flares represent a significant percentage ($\gtrsim 30$\%) of the detected outburst events. Our findings suggest that high-impulse flares are more frequent than suspected from lower-cadence data, so that the most impactful flux levels that hit close-in exoplanets might be more time-limited than expected. We found significant differences in the duration distributions of single-peak and complex flare components, but not in their peak luminosity. A statistical analysis of the flare parameter distributions provides marginal support for their description with a log-normal instead of a power-law function, leaving the door open to several flare formation scenarios. We tentatively confirmed previous results about quasi-periodic pulsations in high-cadence photometry, report the possible detection of a pre-flare dip, and did not find hints of photometric variability due to an undetected flare background. Conclusions. The high-cadence study of stellar hosts might be crucial to evaluate the impact of their flares on close-in exoplanets, as their impulsive phase emission might otherwise be incorrectly estimated. Future telescopes such as PLATO and Ariel will help in this respect., Comment: 28 pages, 25 figures, 4 tables, to be published in Astronomy & Astrophysics

Published
2024

4. CHEOPS and TESS view of the ultra-short period super-Earth TOI-561 b

Author

Patel, J. A., Egger, J. A., Wilson, T. G., Bourrier, V., Carone, L., Beck, M., Ehrenreich, D., Sousa, S. G., Benz, W., Brandeker, A., Deline, A., Alibert, Y., Lam, K. W. F., Lendl, M., Alonso, R., Anglada, G., Bárczy, T., Barrado, D., Barros, S. C. C., Baumjohann, W., Beck, T., Billot, N., Bonfils, X., Broeg, C., Busch, M. -D., Cabrera, J., Charnoz, S., Cameron, A. Collier, Csizmadia, Sz., Davies, M. B., Deleuil, M., Delrez, L., Demangeon, O. D. S., Demory, B. -O., Erikson, A., Fortier, A., Fossati, L., Fridlund, M., Gandolfi, D., Gillon, M., Güdel, M., Heng, K., Hoyer, S., Isaak, K. G., Kiss, L. L., Kopp, E., Laskar, J., Etangs, A. Lecavelier des, Lovis, C., Magrin, D., Maxted, P. F. L., Nascimbeni, V., Olofsson, G., Ottensamer, R., Pagano, I., Pallé, E., Peter, G., Piotto, G., Pollacco, D., Queloz, D., Ragazzoni, R., Rando, N., Ratti, F., Rauer, H., Ribas, I., Santos, N. C., Scandariato, G., Ségransan, D., Simon, A. E., Smith, A. M. S., Steller, M., Szabó, Gy. M., Thomas, N., Udry, S., Ulmer, B., Van Grootel, V., Viotto, V., and Walton, N. A.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Ultra-short period planets (USPs) are a unique class of super-Earths with an orbital period of less than a day and hence subject to intense radiation from their host star. While most of them are consistent with bare rocks, some show evidence of a heavyweight envelope, which could be a water layer or a secondary metal-rich atmosphere sustained by an outgassing surface. Much remains to be learned about the nature of USPs. The prime goal of the present work is to study the bulk planetary properties and atmosphere of TOI-561b, through the study of its transits and occultations. We obtained ultra-precise transit photometry of TOI-561b with CHEOPS and performed a joint analysis of this data with four TESS sectors. Our analysis of TOI-561b transit photometry put strong constraints on its properties, especially on its radius, Rp=1.42 +/- 0.02 R_Earth (at ~2% error). The internal structure modelling of the planet shows that the observations are consistent with negligible H/He atmosphere, however requiring other lighter materials, in addition to pure iron core and silicate mantle to explain the observed density. We find that this can be explained by the inclusion of a water layer in our model. We searched for variability in the measured Rp/R* over time to trace changes in the structure of the planetary envelope but none found within the data precision. In addition to the transit event, we tentatively detect occultation signal in the TESS data with an eclipse depth of ~27 +/- 11 ppm. Using the models of outgassed atmospheres from the literature we find that the thermal emission from the planet can mostly explain the observation. Based on this, we predict that NIR/MIR observations with JWST should be able to detect silicate species in the atmosphere of the planet. This could also reveal important clues about the planetary interior and help disentangle planet formation and evolution models., Comment: 17 pages, 10 + 3 figures, 4 tables, accepted for publication in A&A (abstract abbreviated)

Published
2023
Full Text
View/download PDF

6. A new dynamical modeling of the WASP-47 system with CHEOPS observations

Author

Nascimbeni, V., Borsato, L., Zingales, T., Piotto, G., Pagano, I., Beck, M., Broeg, C., Ehrenreich, D., Hoyer, S., Majidi, F. Z., Granata, V., Sousa, S. G., Wilson, T. G., Van Grootel, V., Bonfanti, A., Salmon, S., Mustill, A. J., Delrez, L., Alibert, Y., Alonso, R., Anglada, G., Bárczy, T., Barrado, D., Barros, S. C. C., Baumjohann, W., Beck, T., Benz, W., Bergomi, M., Billot, N., Bonfils, X., Brandeker, A., Cabrera, J., Charnoz, S., Cameron, A. Collier, Csizmadia, Sz., Cubillos, P. E., Davies, M. B., Deleuil, M., Deline, A., Demangeon, O. D. S., Demory, B. -O., Erikson, A., Fortier, A., Fossati, L., Fridlund, M., Gandolfi, D., Gillon, M., Güdel, M., Isaak, K. G., Kiss, L. L., Laskar, J., Etangs, A. Lecavelier des, Lendl, M., Lovis, C., Luque, R., Magrin, D., Maxted, P. F. L., Mordasini, C., Olofsson, G., Ottensamer, R., Pallé, E., Peter, G., Piazza, D., Pollacco, D., Queloz, D., Ragazzoni, R., Rando, N., Ratti, F., Rauer, H., Ribas, I., Santos, N. C., Scandariato, G., Ségransan, D., Simon, A. E., Smith, A. M. S., Steinberger, M., Steller, M., Szabó, Gy. M., Thomas, N., Udry, S., Venturini, J., Walton, N. A., and Wolter, D.

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract

Among the hundreds of known hot Jupiters (HJs), only five have been found to have companions on short-period orbits. Within this rare class of multiple planetary systems, the architecture of WASP-47 is unique, hosting an HJ (planet -b) with both an inner and an outer sub-Neptunian mass companion (-e and -d, respectively) as well as an additional non-transiting, long-period giant (-c). The small period ratio between planets -b and -d boosts the transit time variation (TTV) signal, making it possible to reliably measure the masses of these planets in synergy with the radial velocity (RV) technique. In this paper, we present new space- and ground-based photometric data of WASP-47b and WASP-47-d, including 11 unpublished light curves from the ESA mission CHEOPS. We analyzed the light curves in a homogeneous way together with all the publicly available data to carry out a global $N$-body dynamical modeling of the TTV and RV signals. We retrieved, among other parameters, a mass and density for planet -d of $M_\mathrm{d}=15.5\pm 0.8$ $M_\oplus$ and $\rho_\mathrm{d}=1.69\pm 0.22$ g\,cm$^{-3}$, which is in good agreement with the literature and consistent with a Neptune-like composition. For the inner planet (-e), we found a mass and density of $M_\mathrm{e}=9.0\pm 0.5$ $M_\oplus$ and $\rho_\mathrm{e}=8.1\pm 0.5$ g\,cm$^{-3}$, suggesting an Earth-like composition close to other ultra-hot planets at similar irradiation levels. Though this result is in agreement with previous RV+TTV studies, it is not in agreement with the most recent RV analysis (at 2.8$\sigma$), which yielded a lower density compatible with a pure silicate composition. This discrepancy highlights the still unresolved issue of suspected systematic offsets between RV and TTV measurements. In this paper, we also significantly improve the orbital ephemerides of all transiting planets, which will be crucial for any future follow-up., Comment: 17 pages, 8 figures, 10 tables, A&A in press. Typos corrected

Published
2023
Full Text
View/download PDF

7. Hint of an exocomet transit in the CHEOPS lightcurve of HD 172555

Author

Kiefer, F., Van Grootel, V., Etangs, A. Lecavelier des, Szabó, Gy. M., Brandeker, A., Broeg, C., Cameron, A. Collier, Deline, A., Olofsson, G., Wilson, T. G., Sousa, S. G., Gandolfi, D., Hébrard, G., Alibert, Y., Alonso, R., Anglada, G., Bárczy, T., Barrado, D., Barros, S. C. C., Baumjohann, W., Beck, M., Beck, T., Benz, W., Billot, N., Bonfils, X., Cabrera, J., Charnoz, S., Csizmadia, Sz., Davies, M. B., Deleuil, M., Delrez, L., Demangeon, O. D. S., Demory, B. -O., Ehrenreich, D., Erikson, A., Fortier, A., Fossati, L., Fridlund, M., Gillon, M., Güdel, M., Heng, K., Hoyer, S., Isaak, K. G., Kiss, L. L., Laskar, J., Lendl, M., Lovis, C., Magrin, D., Maxted, P. F. L., Munari, M., Nascimbeni, V., Ottensamer, R., Pagano, I., Pallé, E., Peter, G., Piazza, D., Piotto, G., Pollacco, D., Queloz, D., Ragazzoni, R., Rando, N., Ratti, F., Rauer, H., Reimers, C., Ribas, I., Santos, N. C., Scandariato, G., Ségransan, D., Simon, A. E., Smith, A. M. S., Steller, M., Thomas, N., Udry, S., Walter, I., and Walton, N. A.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

HD$\,$172555 is a young ($\sim$20$\,$Myr) A7V star surrounded by a 10$\,$au wide debris disk suspected to be replenished partly by collisions between large planetesimals. Small evaporating transiting bodies, exocomets, have also been detected in this system by spectroscopy. After $\beta\,$Pictoris, this is another example of a system possibly witnessing a phase of heavy bombardment of planetesimals. In such system, small bodies trace dynamical evolution processes. We aim at constraining their dust content by using transit photometry. We performed a 2-day-long photometric monitoring of HD$\,$172555 with the CHEOPS space telescope in order to detect shallow transits of exocomets with a typical expected duration of a few hours. The large oscillations in the lightcurve indicate that HD$\,$172555 is a $\delta\,$Scuti pulsating star. Once removing those dominating oscillations, we find a hint for a transient absorption. If fitted with an exocomet transit model, it corresponds to an evaporating body passing near the star at a distance of $6.8\pm1.4\,$R$_\star$ (or $0.05\pm 0.01\,$au) with a radius of 2.5 km. These properties are comparable to those of the exocomets already found in this system using spectroscopy, as well as those found in the $\beta\,$Pic system. The nuclei of solar system's Jupiter family comets, with radii of 2-6$\,$km, are also comparable in size. This is the first evidence for an exocomet photometric transit detection in the young system of HD$\,$172555., Comment: 12 pages, 10 figures, 5 tables, accepted for publication in A&A

Published
2023
Full Text
View/download PDF

8. 55 Cancri e's occultation captured with CHEOPS

Author

Demory, B. -O., Sulis, S., Valdes, E. Meier, Delrez, L., Brandeker, A., Billot, N., Fortier, A., Hoyer, S., Sousa, S. G., Heng, K., Lendl, M., Krenn, A., Morris, B. M., Patel, J. A., Alibert, Y., Alonso, R., Anglada, G., Barczy, T., Barrado, D., Barros, S. C. C., Baumjohann, W., Beck, M., Beck, T., Benz, W., Bonfils, X., Broeg, C., Buder, M., Cabrera, J., Charnoz, S., Cameron, A. Collier, Cottard, H., Csizmadia, Sz., Davies, M. B., Deleuil, M., Demangeon, O. D. S., Ehrenreich, D., Erikson, A., Fossati, L., Fridlund, M., Gandolfi, D., Gillon, M., Gudel, M., Isaak, K. G., Kiss, L. L., Laskar, J., Etangs, A. Lecavelier des, Lovis, C., Luntzer, A., Magrin, D., Marafatto, L., Maxted, P. F. L., Nascimbeni, V., Olofsson, G., Ottensamer, R., Pagano, I., Palle, E., Peter, G., Piotto, G., Pollacco, D., Queloz, D., Ragazzoni, R., Rando, N., Ratti, F., Rauer, H., Ribas, I., Santos, N. C., Scandariato, G., Segransan, D., Simon, A. E., Smith, A. M. S., Steller, M., Szabo, Gy. M., Thomas, N., Udry, S., Van Grootel, V., and Walton, N. A.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Past occultation and phase-curve observations of the ultra-short period super-Earth 55 Cnc e obtained at visible and infrared wavelengths have been challenging to reconcile with a planetary reflection and emission model. In this study, we analyse a set of 41 occultations obtained over a two-year timespan with the CHEOPS satellite. We report the detection of 55 Cnc e's occultation with an average depth of $12\pm3$ ppm. We derive a corresponding 2-$\sigma$ upper limit on the geometric albedo of $A_g < 0.55$ once decontaminated from the thermal emission measured by Spitzer at 4.5$\mu$m. CHEOPS's photometric performance enables, for the first time, the detection of individual occultations of this super-Earth in the visible and identifies short-timescale photometric corrugations likely induced by stellar granulation. We also find a clear 47.3-day sinusoidal pattern in the time-dependent occultation depths that we are unable to relate to stellar noise, nor instrumental systematics, but whose planetary origin could be tested with upcoming JWST occultation observations of this iconic super-Earth., Comment: In press. Accepted for publication in Astronomy and Astrophysics on 13 October 2022. 10 pages, 7 figures and 3 tables

Published
2022
Full Text
View/download PDF

9. A CHEOPS-enhanced view of the HD3167 system

Author

Bourrier, V., Deline, A., Krenn, A., Egger, J. A., Petit, A. C., Malavolta, L., Cretignier, M., Billot, N., Broeg, C., Florén, H. -G., Queloz, D., Alibert, Y., Bonfanti, A., Bonomo, A. S., Delisle, J. -B., Demangeon, O. D. S., Demory, B. -O., Dumusque, X., Ehrenreich, D., Haywood, R. D., Howell, S. B, Lendl, M., Mortier, A., Nigro, G., Salmon, S., Sousa, S. G., Wilson, T. G., Adibekyan, V., Alonso, R., Anglada, G., Bárczy, T., Navascues, D. Barrado y, Barros, S. C. C., Baumjohann, W., Beck, M., Benz, W., Biondi, F., Bonfils, X., Brandeker, A., Cabrera, J., Charnoz, S., Csizmadia, Sz., Cameron, A. Collier, Damasso, M., Davies, M. B., Deleuil, M., Delrez, L., Di Fabrizio, L., Erikson, A., Fortier, A., Fossati, L., Fridlund, M., Gandolfi, D., Gillon, M., Güdel, M., Heng, K., Hoyer, S., Isaak, K. G., Kiss, L. L., Laskar, J., Etangs, A. Lecavelier des, Lorenzi, V., Lovis, C., Magrin, D., Massa, A., Maxted, P. F. L., Nascimbeni, V., Olofsson, G., Ottensamer, R., Pagano, I., Pallé, E., Peter, G., Piotto, G., Pollacco, D., Ragazzoni, R., Rando, N., Rauer, H., Ribas, I., Santos, N. C., Scandariato, G., Ségransan, D., Simon, A. E., Smith, A. M. S., Steller, M., Szabó, Gy. M., Thomas, N., Udry, S., Van Grootel, V., Verrecchia, F., Walton, N., Beck, T., Buder, M., Ratti, F., Ulmer, B., and Viotto, V.

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract

Much remains to be understood about the nature of exoplanets smaller than Neptune, most of which have been discovered in compact multi-planet systems. With its inner ultra-short period planet b aligned with the star and two larger outer planets d-c on polar orbits, the multi-planet system HD 3167 features a peculiar architecture and offers the possibility to investigate both dynamical and atmospheric evolution processes. To this purpose we combined multiple datasets of transit photometry and radial velocimetry (RV) to revise the properties of the system and inform models of its planets. This effort was spearheaded by CHEOPS observations of HD 3167b, which appear inconsistent with a purely rocky composition despite its extreme irradiation. Overall the precision on the planetary orbital periods are improved by an order of magnitude, and the uncertainties on the densities of the transiting planets b and c are decreased by a factor of 3. Internal structure and atmospheric simulations draw a contrasting picture between HD 3167d, likely a rocky super-Earth that lost its atmosphere through photo-evaporation, and HD 3167c, a mini-Neptune that kept a substantial primordial gaseous envelope. We detect a fourth, more massive planet on a larger orbit, likely coplanar with HD 3167d-c. Dynamical simulations indeed show that the outer planetary system d-c-e was tilted, as a whole, early in the system history, when HD 3167b was still dominated by the star influence and maintained its aligned orbit. RV data and direct imaging rule out that the companion that could be responsible for the present-day architecture is still bound to the HD\,3167 system. Similar global studies of multi-planet systems will tell how many share the peculiar properties of the HD3167 system, which remains a target of choice for follow-up observations and simulations., Comment: 22 pages, 23 pages, accepted for publication in A&A (18 August 2022). Updated author list in new version

Published
2022
Full Text
View/download PDF

10. A stellar occultation by the transneptunian object (50000) Quaoar observed by CHEOPS

Author

Morgado, B. E., Bruno, G., Gomes-Júnior, A. R., Pagano, I., Sicardy, B., Fortier, A., Desmars, J., Maxted, P. F. L., Braga-Ribas, F., Queloz, D., Sousa, S. G., Ortiz, J. L., Brandeker, A., Cameron, A. Collier, Pereira, C. L., Florén, H. G., Hara, N., Souami, D., Isaak, K. G., Olofsson, G., Santos-Sanz, P., Wilson, T. G., Broughton, J., Alibert, Y., Alonso, R., Anglada, G., Bárczy, T., Barrado, D., Barros, S. C. C., Baumjohann, W., Beck, M., Beck, T., Benz, W., Billot, N., Bonfils, X., Broeg, C., Cabrera, J., Charnoz, S., Csizmadia, S., Davies, M. B., Deleuil, M., Delrez, L., Demangeon, O. D. S., Demory, B. O., Ehrenreich, D., Erikson, A., Fossati, L., Fridlund, M., Gandolfi, D., Gillon, M., Güdel, M., Heng, K., Hoyer, S., Kiss, L. L., Laskar, J., Etangs, A. Lecavelier des, Lendl, M., Lovis, C., Magrin, D., Marafatto, L., Nascimbeni, V., Ottensamer, R., Pallé, E., Peter, G., Piazza, D., Piotto, G., Pollacco, D., Ragazzoni, R., Rando, N., Ratti, F., Rauer, H., Reimers, C., Ribas, I., Santos, N. C., Scandariato, G., Ségransan, D., Simon, A. E., Smith, A. M. S., Steller, M., Szabó, G. M., Thomas, N., Udry, S., Van Grootel, V., Walton, N. A., and Westerdorff, K.

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Stellar occultation is a powerful technique that allows the determination of some physical parameters of the occulting object. The result depends on the photometric accuracy, the temporal resolution, and the number of chords obtained. Space telescopes can achieve high photometric accuracy as they are not affected by atmospheric scintillation. Using ESA's CHEOPS space telescope, we observed a stellar occultation by the Transneptunian object (50000) Quaoar. We compare the obtained chord with previous occultations by this object and determine its astrometry with sub-milliarcsecond precision. Also, we determine upper limits to the presence of a global methane atmosphere on the occulting body. We predicted and observed a stellar occultation by Quaoar using the CHEOPS space telescope. We measured the occultation light curve from this data-set and determined the dis- and re-appearance of the star behind the occulting body. Furthermore, a ground-based telescope in Australia was used to constrain Quaoar's limb. Combined with results from previous works, these measurements allow us to obtain a precise position of Quaoar at the occultation time. We present results obtained from the first stellar occultation by a Transneptunian object (TNO) using space telescope orbiting Earth. It was the occultation by Quaoar observed on 2020 June 11. We used the CHEOPS light curve to obtain a surface pressure upper limit of 85 nbar for the detection of a global methane atmosphere. Also, combining this observation with a ground-based observation we fit Quaoar's limb to determine its astrometric position with an uncertainty below 1.0 mas. This observation is a first of its kind, and it shall be considered as a proof of concept of stellar occultation observations of Transneptunian objects with space telescopes orbiting Earth. Moreover, it shows significant prospects for the James Webb Space Telescope., Comment: 9 pages, 10 figures

Published
2022
Full Text
View/download PDF

11. The stable climate of KELT-9b

Author

Jones, K. D., Morris, B. M., Demory, B. -O., Heng, K., Hooton, M. J., Billot, N., Ehrenreich, D., Hoyer, S., Simon, A. E., Lendl, M., Demangeon, O. D. S., Sousa, S. G., Bonfanti, A., Wilson, T. G., Salmon, S., Csizmadia, Sz., Parviainen, H., Bruno, G., Alibert, Y., Alonso, R., Anglada, G., Bárczy, T., Navascues, D. Barrado y, Barros, S. C. C., Baumjohann, W., Beck, M., Beck, T., Benz, W., Bonfils, X., Brandeker, A., Broeg, C., Cabrera, J., Charnoz, S., Cameron, A. Collier, Davies, M. B., Deleuil, M., Deline, A., Delrez, L., Erikson, A., Fortier, A., Fossati, L., Fridlund, M., Gandolfi, D., Gillon, M., Güdel, M., Isaak, K. G., Kiss, L. L., Laskar, J., Etangs, A. Lecavelier des, Lovis, C., Magrin, D., Maxted, P. F. L., Nascimbeni, V., Olofsson, G., Ottensamer, R., Pagano, I., Pallé, E., Peter, G., Piotto, G., Pollacco, D., Queloz, D., Ragazzoni, R., Rando, N., Ratti, F., Rauer, H., Reimers, C., Ribas, I., Santos, N. C., Scandariato, G., Ségransan, D., Smith, A. M. S., Steller, M., Szabó, Gy. M., Thomas, N., Udry, S., Van Grootel, V., Walter, I., Walton, N. A., and Jungo, W. Wang

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Even among the most irradiated gas giants, so-called ultra-hot Jupiters, KELT-9b stands out as the hottest planet thus far discovered with a dayside temperature of over 4500K. At these extreme irradiation levels, we expect an increase in heat redistribution efficiency and a low Bond albedo owed to an extended atmosphere with molecular hydrogen dissociation occurring on the planetary dayside. We present new photometric observations of the KELT-9 system throughout 4 full orbits and 9 separate occultations obtained by the 30cm space telescope CHEOPS. The CHEOPS bandpass, located at optical wavelengths, captures the peak of the thermal emission spectrum of KELT-9b. In this work we simultaneously analyse CHEOPS phase curves along with public phase curves from TESS and Spitzer to infer joint constraints on the phase curve variation, gravity-darkened transits, and occultation depth in three bandpasses, as well as derive 2D temperature maps of the atmosphere at three different depths. We find a day-night heat redistribution efficiency of $\sim$0.3 which confirms expectations of enhanced energy transfer to the planetary nightside due to dissociation and recombination of molecular hydrogen. We also calculate a Bond albedo consistent with zero. We find no evidence of variability of the brightness temperature of the planet, excluding variability greater than 1% (1$\sigma$)., Comment: 21 pages, 9 figures, accepted for publication in A&A

Published
2022
Full Text
View/download PDF

12. The HD 93963 A transiting system: A 1.04d super-Earth and a 3.65 d sub-Neptune discovered by TESS and CHEOPS

Author

Serrano, L. M., Gandolfi, D., Hoyer, S., Brandeker, A., Hooton, M. J., Sousa, S., Murgas, F., Ciardi, D. R., Howell, S. B., Benz, W., Billot, N., Florén, H. -G., Bekkelien, A., Bonfanti, A., Krenn, A., Mustill, A. J., Wilson, T. G., Osborn, H., Parviainen, H., Heidari, N., Pallé, E., Fridlund, M., Adibekyan, V., Fossati, L., Deleuil, M., Knudstrup, E., Collins, K. A., Lam, K. W. F., Grziwa, S., Salmon, S., Albrecht, S. H., Alibert, Y., Alonso, R., Anglada-Escudé, G., Bárczy, T., Navascues, D. Barrado y, Barros, S. C. C., Baumjohann, W., Beck, M., Beck, T., Bieryla, A., Bonfils, X., Boyd, P. T., Broeg, C., Cabrera, J., Charnoz, S., Chazelas, B., Christiansen, J. L., Cameron, A. Collier, Cortés-Zuleta, P., Csizmadia, Sz., Davies, M. B., Deline, A., Delrez, L., Demangeon, O. D. S., Demory, B. -O., Dunlavey, A., Ehrenreich, D., Erikson, A., Fortier, A., Fukui, A., Garai, Z., Gillon, M., Güdel, M., Hébrard, G., Heng, K., Huang, C. X., Isaak, K. G., Jenkins, J. M., Kiss, L. L., Laskar, J., Latham, D. W., Etangs, A. Lecavelier des, Lendl, M., Levine, A. M., Lovis, C., Lund, M. B., Magrin, D., Maxted, P. F. L., Narita, N., Nascimbeni, V., Olofsson, G., Ottensamer, R., Pagano, I., Pessanha, A. C. S. V., Peter, G., Piotto, G., Pollacco, D., Queloz, D., Ragazzoni, R., Rando, N., Ratti, F., Rauer, H., Ribas, I., Ricker, G., Rowden, P., Santos, N. C., Scandariato, G., Seager, S., Ségransan, D., Simon, A. E., Smith, A. M. S., Steller, M., Szabó, Gy. M., Thomas, N., Twicken, J. D., Udry, S., Ulmer, B., Van Grootel, V., Vanderspek, R., Viotto, V., and Walton, N.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

We present the discovery of two small planets transiting HD 93963A (TOI-1797), a G0\,V star (M$_*$=1.109\,$\pm$\,0.043\,M$_\odot$, R$_*$=1.043\,$\pm$\,0.009\,R$_\odot$) in a visual binary system. We combined TESS and CHEOPS space-borne photometry with data from MuSCAT 2, `Alopeke, PHARO, TRES, FIES, and SOPHIE. We validated and spectroscopically confirmed the outer transiting planet HD 93963 Ac, a sub-Neptune with an orbital period of P$_c \approx$ 3.65 d, reported as a TESS object of interest (TOI) shortly after the release of Sector 22 data. HD 93963 Ac has a mass of M$_c = 19.2 \pm 4.1$ M$_{\oplus}$ and a radius of R$_c = 3.228 \pm 0.059$ R$_{\oplus}$, implying a mean density of $\rho_c=3.1\pm0.7$ gcm$^{-3}$. The inner object, HD 93963 Ab, is a validated 1.04 d ultra-short period (USP) transiting super-Earth that we discovered in the TESS light curve and that was not listed as a TOI, owing to the low significance of its signal (TESS signal-to-noise ratio $\approx$ 6.7, TESS $+$ CHEOPS combined transit depth D$_b=141.5 \pm 8.5$ ppm). We intensively monitored the star with CHEOPS by performing nine transit observations to confirm the presence of the inner planet and validate the system. HD 93963 Ab is the first small (R$_b = 1.35 \pm 0.042$ R$_{\oplus}$) USP planet discovered and validated by TESS and CHEOPS. Unlike planet c, HD 93963 Ab is not significantly detected in our radial velocities (M$_b = 7.8 \pm 3.2$ M$_{\oplus}$). We also discovered a linear trend in our Doppler measurements, suggesting the possible presence of a long-period outer planet. With a V-band magnitude of 9.2, HD 93963 A is among the brightest stars known to host a USP planet, making it one of the most favourable targets for precise mass measurement via Doppler spectroscopy and an important laboratory to test formation, evolution, and migration models of planetary systems hosting ultra-short period planets., Comment: Accepted in Astronomy & Astrophysics

Published
2022
Full Text
View/download PDF

13. Investigating the architecture and internal structure of the TOI-561 system planets with CHEOPS, HARPS-N and TESS

Author

Lacedelli, G., Wilson, T. G., Malavolta, L., Hooton, M. J., Cameron, A. Collier, Alibert, Y., Mortier, A., Bonfanti, A., Haywood, R. D., Hoyer, S., Piotto, G., Bekkelien, A., Vanderburg, A. M., Benz, W., Dumusque, X., Deline, A., López-Morales, M., Borsato, L., Rice, K., Fossati, L., Latham, D. W., Brandeker, A., Poretti, E., Sousa, S. G., Sozzetti, A., Salmon, S., Burke, C. J., Van Grootel, V., Fausnaugh, M. M., Adibekyan, V., Huang, C. X., Osborn, H. P., Mustill, A. J., Pallé, E., Bourrier, V., Nascimbeni, V., Alonso, R., Anglada, G., Bárczy, T., Navascues, D. Barrado y, Barros, S. C. C., Baumjohann, W., Beck, M., Beck, T., Billot, N., Bonfils, X., Broeg, C., Buchhave, L. A., Cabrera, J., Charnoz, S., Cosentino, R., Csizmadia, Sz., Davies, M. B., Deleuil, M., Delrez, L., Demangeon, O., Demory, B. -O., Ehrenreich, D., Erikson, A., Esparza-Borges, E., Florén, H. -G., Fortier, A., Fridlund, M., Futyan, D., Gandolfi, D., Ghedina, A., Gillon, M., Güdel, M., Gutermann, P., Harutyunyan, A., Heng, K., Isaak, K. G., Jenkins, J. M., Kiss, L., Laskar, J., Etangs, A. Lecavelier des, Lendl, M., Lovis, C., Magrin, D., Marafatto, L., Fiorenzano, A. F. Martinez, Maxted, P. F. L., Mayor, M., Micela, G., Molinari, E., Murgas, F., Narita, N., Olofsson, G., Ottensamer, R., Pagano, I., Pasetti, A., Pedani, M., Pepe, F. A., Peter, G., Phillips, D. F., Pollacco, D., Queloz, D., Ragazzoni, R., Rando, N., Ratti, F., Rauer, H., Ribas, I., Santos, N. C., Sasselov, D., Scandariato, G., Seager, S., Ségransan, D., Serrano, L. M., Simon, A. E., Smith, A. M. S., Steinberger, M., Steller, M., Szabó, Gy., Thomas, N., Twicken, J. D., Udry, S., Walton, N., and Winn, J. N.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

We present a precise characterization of the TOI-561 planetary system obtained by combining previously published data with TESS and CHEOPS photometry, and a new set of $62$ HARPS-N radial velocities (RVs). Our joint analysis confirms the presence of four transiting planets, namely TOI-561 b ($P = 0.45$ d, $R = 1.42$ R$_\oplus$, $M = 2.0$ M$_\oplus$), c ($P = 10.78$ d, $R = 2.91$ R$_\oplus$, $M = 5.4$ M$_\oplus$), d ($P = 25.7$ d, $R = 2.82$ R$_\oplus$, $M = 13.2$ M$_\oplus$) and e ($P = 77$ d, $R = 2.55$ R$_\oplus$, $M = 12.6$ M$_\oplus$). Moreover, we identify an additional, long-period signal ($>450$ d) in the RVs, which could be due to either an external planetary companion or to stellar magnetic activity. The precise masses and radii obtained for the four planets allowed us to conduct interior structure and atmospheric escape modelling. TOI-561 b is confirmed to be the lowest density ($\rho_{\rm b} = 3.8 \pm 0.5$ g cm$^{-3}$) ultra-short period (USP) planet known to date, and the low metallicity of the host star makes it consistent with the general bulk density-stellar metallicity trend. According to our interior structure modelling, planet b has basically no gas envelope, and it could host a certain amount of water. In contrast, TOI-561 c, d, and e likely retained an H/He envelope, in addition to a possibly large water layer. The inferred planetary compositions suggest different atmospheric evolutionary paths, with planets b and c having experienced significant gas loss, and planets d and e showing an atmospheric content consistent with the original one. The uniqueness of the USP planet, the presence of the long-period planet TOI-561 e, and the complex architecture make this system an appealing target for follow-up studies., Comment: 22 pages, 19 figures. Accepted for publication in MNRAS

Published
2022
Full Text
View/download PDF

14. A resonant sextuplet of sub-Neptunes transiting the bright star HD 110067

Author

Luque, R., Osborn, H. P., Leleu, A., Pallé, E., Bonfanti, A., Barragán, O., Wilson, T. G., Broeg, C., Cameron, A. Collier, Lendl, M., Maxted, P. F. L., Alibert, Y., Gandolfi, D., Delisle, J.-B., Hooton, M. J., Egger, J. A., Nowak, G., Lafarga, M., Rapetti, D., Twicken, J. D., Morales, J. C., Carleo, I., Orell-Miquel, J., Adibekyan, V., Alonso, R., Alqasim, A., Amado, P. J., Anderson, D. R., Anglada-Escudé, G., Bandy, T., Bárczy, T., Barrado Navascues, D., Barros, S. C. C., Baumjohann, W., Bayliss, D., Bean, J. L., Beck, M., Beck, T., Benz, W., Billot, N., Bonfils, X., Borsato, L., Boyle, A. W., Brandeker, A., Bryant, E. M., Cabrera, J., Carrazco-Gaxiola, S., Charbonneau, D., Charnoz, S., Ciardi, D. R., Cochran, W. D., Collins, K. A., Crossfield, I. J. M., Csizmadia, Sz., Cubillos, P. E., Dai, F., Davies, M. B., Deeg, H. J., Deleuil, M., Deline, A., Delrez, L., Demangeon, O. D. S., Demory, B.-O., Ehrenreich, D., Erikson, A., Esparza-Borges, E., Falk, B., Fortier, A., Fossati, L., Fridlund, M., Fukui, A., Garcia-Mejia, J., Gill, S., Gillon, M., Goffo, E., Gómez Maqueo Chew, Y., Güdel, M., Guenther, E. W., Günther, M. N., Hatzes, A. P., Helling, Ch., Hesse, K. M., Howell, S. B., Hoyer, S., Ikuta, K., Isaak, K. G., Jenkins, J. M., Kagetani, T., Kiss, L. L., Kodama, T., Korth, J., Lam, K. W. F., Laskar, J., Latham, D. W., Lecavelier des Etangs, A., Leon, J. P. D., Livingston, J. H., Magrin, D., Matson, R. A., Matthews, E. C., Mordasini, C., Mori, M., Moyano, M., Munari, M., Murgas, F., Narita, N., Nascimbeni, V., Olofsson, G., Osborne, H. L. M., Ottensamer, R., Pagano, I., Parviainen, H., Peter, G., Piotto, G., Pollacco, D., Queloz, D., Quinn, S. N., Quirrenbach, A., Ragazzoni, R., Rando, N., Ratti, F., Rauer, H., Redfield, S., Ribas, I., Ricker, G. R., Rudat, A., Sabin, L., Salmon, S., Santos, N. C., Scandariato, G., Schanche, N., Schlieder, J. E., Seager, S., Ségransan, D., Shporer, A., Simon, A. E., Smith, A. M. S., Sousa, S. G., Stalport, M., Szabó, Gy. M., Thomas, N., Tuson, A., Udry, S., Vanderburg, A. M., Van Eylen, V., Van Grootel, V., Venturini, J., Walter, I., Walton, N. A., Watanabe, N., Winn, J. N., and Zingales, T.

Published
2023
Full Text
View/download PDF

15. Spi-OPS: Spitzer and CHEOPS confirm the near-polar orbit of MASCARA-1 b and reveal a hint of dayside reflection

Author

Hooton, M. J., Hoyer, S., Kitzmann, D., Morris, B. M., Smith, A. M. S., Cameron, A. Collier, Futyan, D., Maxted, P. F. L., Queloz, D., Demory, B. -O., Heng, K., Lendl, M., Cabrera, J., Csizmadia, Sz., Deline, A., Parviainen, H., Salmon, S., Sulis, S., Wilson, T. G., Bonfanti, A., Brandeker, A., Demangeon, O. D. S., Oshagh, M., Persson, C. M., Scandariato, G., Alibert, Y., Alonso, R., Escudé, G. Anglada, Bárczy, T., Barrado, D., Barros, S. C. C., Baumjohann, W., Beck, M., Beck, T., Benz, W., Billot, N., Bonfils, X., Bourrier, V., Broeg, C., Busch, M. -D., Charnoz, S., Davies, M. B., Deleuil, M., Delrez, L., Ehrenreich, D., Erikson, A., Farinato, J., Fortier, A., Fossati, L., Fridlund, M., Gandolfi, D., Gillon, M., Güdel, M., Isaak, K. G., Jones, K., Kiss, L., Laskar, J., Etangs, A. Lecavelier des, Lovis, C., Luntzer, A., Magrin, D., Nascimbeni, V., Olofsson, G., Ottensamer, R., Pagano, I., Pallé, E., Peter, G., Piotto, G., Pollacco, D., Ragazzoni, R., Rando, N., Ratti, F., Rauer, H., Ribas, I., Santos, N. C., Ségransan, D., Simon, A. E., Sousa, S. G., Steller, M., Szabó, Gy. M., Thomas, N., Udry, S., Ulmer, B., Van Grootel, V., and Walton, N. A.

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The light curves of tidally locked hot Jupiters transiting fast-rotating, early-type stars are a rich source of information about both the planet and star, with full-phase coverage enabling a detailed atmospheric characterisation of the planet. Although it is possible to determine the true spin-orbit angle $\Psi$, a notoriously difficult parameter to measure, from any transit asymmetry resulting from gravity darkening induced by the stellar rotation, the correlations that exist between the transit parameters have led to large disagreements in published values of $\Psi$ for some systems. We aimed to study these phenomena in the light curves of the ultra-hot Jupiter MASCARA-1 b. We obtained optical CHEOPS transit and occultation light curves of MASCARA-1 b, and analysed them jointly with a Spitzer/IRAC 4.5 $\mu$m full-phase curve. When fitting the CHEOPS and Spitzer transits together, the degeneracies are greatly diminished and return results consistent with previously published Doppler tomography. Placing priors informed by the tomography achieves even better precision, allowing a determination of $\Psi=72.1^{+2.5}_{-2.4}$ deg. From the occultations and phase variations, we derived dayside and nightside temperatures of $3062^{+66}_{-68}$ K and $1720\pm330$ K, respectively. In addition, we could separately derive geometric albedo $A_g=0.171^{+0.066}_{-0.068}$ and spherical albedo $A_s=0.266^{+0.097}_{-0.100}$ from the CHEOPS data, and Bond albedo $A_B=0.057^{+0.083}_{-0.101}$ from the Spitzer phase curve. Where possible, priors informed by Doppler tomography should be used when fitting transits of fast-rotating stars, though multi-colour photometry may also unlock an accurate measurement of $\Psi$. Our approach to modelling the phase variations at different wavelengths provides a template for how to separate thermal emission from reflected light in spectrally resolved JWST phase curves., Comment: 26 pages, 16 figures. Accepted in A&A

Published
2021
Full Text
View/download PDF

16. Six transiting planets and a chain of Laplace resonances in TOI-178

Author

Leleu, A., Alibert, Y., Hara, N. C., Hooton, M. J., Wilson, T. G., Robutel, P., Delisle, J. -B., Laskar, J., Hoyer, S., Lovis, C., Bryant, E. M., Ducrot, E., Cabrera, J., Delrez, L., Acton, J. S., Adibekyan, V., Allart, R., Prieto, C. Allende, Alonso, R., Alves, D., Anderson, D. R., Angerhausen, D., Escudé, G. Anglada, Asquier, J., Barrado, D., Barros, S. C. C., Baumjohann, W., Bayliss, D., Beck, M., Beck, T., Bekkelien, A., Benz, W., Billot, N., Bonfanti, A., Bonfils, X., Bouchy, F., Bourrier, V., Boué, G., Brandeker, A., Broeg, C., Buder, M., Burdanov, A., Burleigh, M. R., Bárczy, T., Cameron, A. C., Chamberlain, S., Charnoz, S., Cooke, B. F., Van Damme, C. Corral, Correia, A. C. M., Cristiani, S., Damasso, M., Davies, M. B., Deleuil, M., Demangeon, O. D. S., Demory, B. -O., Di Marcantonio, P., Di Persio, G., Dumusque, X., Ehrenreich, D., Erikson, A., Figueira, P., Fortier, A., Fossati, L., Fridlund, M., Futyan, D., Gandolfi, D., Muñoz, A. García, Garcia, L. J., Gill, S., Gillen, E., Gillon, M., Goad, M. R., Hernández, J. I. González, Guedel, M., Günther, M. N., Haldemann, J., Henderson, B., Heng, K., Hogan, A. E., Isaak, K., Jehin, E., Jenkins, J. S., Jordán, A., Kiss, L., Kristiansen, M. H., Lam, K., Lavie, B., Etangs, A. Lecavelier des, Lendl, M., Lillo-Box, J., Curto, G. Lo, Magrin, D., Martins, C. J. A. P., Maxted, P. F. L., McCormac, J., Mehner, A., Micela, G., Molaro, P., Moyano, M., Murray, C. A., Nascimbeni, V., Nunes, N. J., Olofsson, G., Osborn, H. P., Oshagh, M., Ottensamer, R., Pagano, I., Pallé, E., Pedersen, P. P., Pepe, F. A., Persson, C. M., Peter, G., Piotto, G., Polenta, G., Pollacco, D., Poretti, E., Pozuelos, F. J., Queloz, D., Ragazzoni, R., Rando, N., Ratti, F., Rauer, H., Raynard, L., Rebolo, R., Reimers, C., Ribas, I., Santos, N. C., Scandariato, G., Schneider, J., Sebastian, D., Sestovic, M., Simon, A. E., Smith, A. M. S., Sousa, S. G., Sozzetti, A., Steller, M., Mascareño, A. Suárez, Szabó, Gy. M., Ségransan, D., Thomas, N., Thompson, S., Tilbrook, R. H., Triaud, A., Turner, O., Udry, S., Van Grootel, V., Venus, H., Verrecchia, F., Vines, J. I., Walton, N. A., West, R. G., Wheatley, P. J., Wolter, D., and Osorio, M. R. Zapatero

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Determining the architecture of multi-planetary systems is one of the cornerstones of understanding planet formation and evolution. Resonant systems are especially important as the fragility of their orbital configuration ensures that no significant scattering or collisional event has taken place since the earliest formation phase when the parent protoplanetary disc was still present. In this context, TOI-178 has been the subject of particular attention since the first TESS observations hinted at a 2:3:3 resonant chain. Here we report the results of observations from CHEOPS, ESPRESSO, NGTS, and SPECULOOS with the aim of deciphering the peculiar orbital architecture of the system. We show that TOI-178 harbours at least six planets in the super-Earth to mini-Neptune regimes, with radii ranging from 1.152(-0.070/+0.073) to 2.87(-0.13/+0.14) Earth radii and periods of 1.91, 3.24, 6.56, 9.96, 15.23, and 20.71 days. All planets but the innermost one form a 2:4:6:9:12 chain of Laplace resonances, and the planetary densities show important variations from planet to planet, jumping from 1.02(+0.28/-0.23) to 0.177(+0.055/-0.061) times the Earth's density between planets c and d. Using Bayesian interior structure retrieval models, we show that the amount of gas in the planets does not vary in a monotonous way, contrary to what one would expect from simple formation and evolution models and unlike other known systems in a chain of Laplace resonances. The brightness of TOI-178 allows for a precise characterisation of its orbital architecture as well as of the physical nature of the six presently known transiting planets it harbours. The peculiar orbital configuration and the diversity in average density among the planets in the system will enable the study of interior planetary structures and atmospheric evolution, providing important clues on the formation of super-Earths and mini-Neptunes.

Published
2021
Full Text
View/download PDF

17. CHEOPS observations of the HD 108236 planetary system: A fifth planet, improved ephemerides, and planetary radii

Author

Bonfanti, A., Delrez, L., Hooton, M. J., Wilson, T. G., Fossati, L., Alibert, Y., Hoyer, S., Mustill, A. J., Osborn, H. P., Adibekyan, V., Gandolfi, D., Salmon, S., Sousa, S. G., Tuson, A., Van Grootel, V., Cabrera, J., Nascimbeni, V., Maxted, P. F. L., Barros, S. C. C., Billot, N., Bonfils, X., Borsato, L., Broeg, C., Davies, M. B., Deleuil, M., Demangeon, O. D. S., Fridlund, M., Lacedelli, G., Lendl, M., Persson, C., Santos, N. C., Scandariato, G., Szabó, Gy. M., Cameron, A. Collier, Udry, S., Benz, W., Beck, M., Ehrenreich, D., Fortier, A., Isaak, K. G., Queloz, D., Alonso, R., Asquier, J., Bandy, T., Bárczy, T., Barrado, D., Barragán, O., Baumjohann, W., Beck, T., Bekkelien, A., Bergomi, M., Busch, M-D., Brandeker, A., Cessa, V., Charnoz, S., Chazelas, B., Van Damme, C. Corral, Demory, B. -O., Erikson, A., Farinato, J., Futyan, D., Muñoz, A. Garcia, Gillon, M., Guedel, M., Guterman, P., Hasiba, J., Heng, K., Hernandez, E., Kiss, L., Kuntzer, T., Laskar, J., Etangs, A. Lecavelier des, Lovis, C., Magrin, D., Malvasio, L., Marafatto, L., Michaelis, H., Munari, M., Olofsson, G., Ottacher, H., Ottensamer, R., Pagano, I., Pallé, E., Peter, G., Piazza, D., Piotto, G., Pollacco, D., Ragazzoni, R., Rando, N., Ratti, F., Rauer, H., Ribas, I., Rieder, M., Rohlfs, R., Safa, F., Salatti, M., Ségransan, D., Simon, A. E., Smith, A. M. S., Sordet, M., Steller, M., Thomas, N., Tschentscher, M., Van Eylen, V., Viotto, V., Walter, I., Walton, N. A., Wildi, F., and Wolter, D.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

The detection of a super-Earth and three mini-Neptunes transiting the bright ($V$ = 9.2 mag) star HD 108236 (also known as TOI-1233) was recently reported on the basis of TESS and ground-based light curves. We perform a first characterisation of the HD 108236 planetary system through high-precision CHEOPS photometry and improve the transit ephemerides and system parameters. We characterise the host star through spectroscopic analysis and derive the radius with the infrared flux method. We constrain the stellar mass and age by combining the results obtained from two sets of stellar evolutionary tracks. We analyse the available TESS light curves and one CHEOPS transit light curve for each known planet in the system. We find that HD 108236 is a Sun-like star with $R_{\star}=0.877\pm0.008 R_{\odot}$, $M_{\star}=0.869^{+0.050}_{-0.048} M_{\odot}$, and an age of $6.7_{-5.1}^{+4.0}$ Gyr. We report the serendipitous detection of an additional planet, HD 108236 f, in one of the CHEOPS light curves. For this planet, the combined analysis of the TESS and CHEOPS light curves leads to a tentative orbital period of about 29.5 days. From the light curve analysis, we obtain radii of $1.615\pm0.051$, $2.071\pm0.052$, $2.539_{-0.065}^{+0.062}$, $3.083\pm0.052$, and $2.017_{-0.057}^{+0.052}$ $R_{\oplus}$ for planets HD 108236 b to HD 108236 f, respectively. These values are in agreement with previous TESS-based estimates, but with an improved precision of about a factor of two. We perform a stability analysis of the system, concluding that the planetary orbits most likely have eccentricities smaller than 0.1. We also employ a planetary atmospheric evolution framework to constrain the masses of the five planets, concluding that HD 108236 b and HD 108236 c should have an Earth-like density, while the outer planets should host a low mean molecular weight envelope., Comment: 20 pages, 14 figures, accepted for publication by A&A

Published
2021
Full Text
View/download PDF

18. The hot dayside and asymmetric transit of WASP-189b seen by CHEOPS

Author

Lendl, M., Csizmadia, Sz., Deline, A., Fossati, L., Kitzmann, D., Heng, K., Hoyer, S., Salmon, S., Benz, W., Broeg, C., Ehrenreich, D., Fortier, A., Queloz, D., Bonfanti, A., Brandeker, A., Cameron, A. Collier, Delrez, L., Muñoz, A. Garcia, Hooton, M. J., Maxted, P. F. L., Morris, B. M., Van Grootel, V., Wilson, T. G., Alibert, Y., Alonso, R., Asquier, J., Bárczy, T. Bandy T., Barrado, D., Barros, S. C. C, Baumjohann, W., Beck, M., Beck, T., Bekkelien, A., Bergomi, M., Billot, N., Biondi, F., Bonfils, X., Bourrier, V., Busch, M-D., Cabrera, J., Cessa, V., Charnoz, S., Chazelas, B., Van Damme, C. Corral, Davies, M. B., Deleuil, M., Demangeon, O. D. S, Demory, B. -O., Erikson, A., Farinato, J., Fridlund, M., Futyan, D., Gandolfi, D., Gillon, M., Guterman, P., Hasiba, J., Hernandez, E., Isaak, K. G., Kiss, L., Kuntzer, T., Etangs, A. Lecavelier des, Lüftinger, T., Laskar, J., Lovis, C., Magrin, D., Malvasio, L., Marafatto, L., Michaelis, H., Munari, M., Nascimbeni, V., Olofsson, G., Ottacher, H., Ottensamer, R., Pagano, I., Pallé, E., Peter, G., Piazza, D., Piotto, G., Pollacco, D., Ratti, F., Rauer, H., Ragazzoni, R., Rando, N., Ribas, I., Rieder, M., Rohlfs, R., Safa, F., Santos, N. C., Scandariato, G., Ségransan, D., Simon, A. E., Singh, V., Smith, A. M. S., Sordet, M., Sousa, S. G., Steller, M., Szabó, Gy. M., Thomas, N., Tschentscher, M., Udry, S., Viotto, V., Walter, I., Walton, N. A., Wildi, F., and Wolter, D.

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract

The CHEOPS space mission dedicated to exoplanet follow-up was launched in December 2019, equipped with the capacity to perform photometric measurements at the 20 ppm level. As CHEOPS carries out its observations in a broad optical passband, it can provide insights into the reflected light from exoplanets and constrain the short-wavelength thermal emission for the hottest of planets by observing occultations and phase curves. Here, we report the first CHEOPS observation of an occultation, namely, that of the hot Jupiter WASP-189b, a $M_P \approx 2 M_J$ planet orbiting an A-type star. We detected the occultation of WASP-189 b at high significance in individual measurements and derived an occultation depth of $dF = 87.9 \pm 4.3$ppm based on four occultations. We compared these measurements to model predictions and we find that they are consistent with an unreflective atmosphere heated to a temperature of $3435 \pm 27$K, when assuming inefficient heat redistribution. Furthermore, we present two transits of WASP-189b observed by CHEOPS. These transits have an asymmetric shape that we attribute to gravity darkening of the host star caused by its high rotation rate. We used these measurements to refine the planetary parameters, finding a $\sim25\%$ deeper transit compared to the discovery paper and updating the radius of WASP-189b to $1.619\pm0.021 R_J$. We further measured the projected orbital obliquity to be $\lambda = 86.4^{+2.9}_{-4.4}$deg, a value that is in good agreement with a previous measurement from spectroscopic observations, and derived a true obliquity of $\Psi = 85.4\pm4.3$deg. Finally, we provide reference values for the photometric precision attained by the CHEOPS satellite: for the V=6.6 mag star, and using a one-hour binning, we obtain a residual RMS between 10 and 17ppm on the individual light curves, and 5.7ppm when combining the four visits., Comment: In press at Astronomy and Astrophysics

Published
2020
Full Text
View/download PDF

19. Dragon 1 Protocol Manuscript: Training, Accreditation, Implementation and Safety Evaluation of Portal and Hepatic Vein Embolization (PVE/HVE) to Accelerate Future Liver Remnant (FLR) Hypertrophy

Author

Korenblik, R., Olij, B., Aldrighetti, L. A., Hilal, M. Abu, Ahle, M., Arslan, B., van Baardewijk, L. J., Baclija, I., Bent, C., Bertrand, C. L., Björnsson, B., de Boer, M. T., de Boer, S. W., Bokkers, R. P. H., Rinkes, I. H. M. Borel, Breitenstein, S., Bruijnen, R. C. G., Bruners, P., Büchler, M. W., Camacho, J. C., Cappelli, A., Carling, U., Chan, B. K. Y., Chang, D. H., choi, J., Font, J. Codina, Crawford, M., Croagh, D., Cugat, E., Davis, R., De Boo, D. W., De Cobelli, F., De Wispelaere, J. F., van Delden, O. M., Delle, M., Detry, O., Díaz-Nieto, R., Dili, A., Erdmann, J. I., Fisher, O., Fondevila, C., Fretland, Å., Borobia, F. Garcia, Gelabert, A., Gérard, L., Giuliante, F., Gobardhan, P. D., Gómez, F., Grünberger, T., Grünhagen, D. J., Guitart, J., Hagendoorn, J., Heil, J., Heise, D., Herrero, E., Hess, G. F., Hoffmann, M. H., Iezzi, R., Imani, F., Nguyen, J., Jovine, E., Kalff, J. C., Kazemier, G., Kingham, T. P., Kleeff, J., Kollmar, O., Leclercq, W. K. G., Ben, S. Lopez, Lucidi, V., MacDonald, A., Madoff, D. C., Manekeller, S., Martel, G., Mehrabi, A., Mehrzad, H., Meijerink, M. R., Menon, K., Metrakos, P., Meyer, C., Moelker, A., Modi, S., Montanari, N., Navines, J., Neumann, U. P., Peddu, P., Primrose, J. N., Qu, X., Raptis, D., Ratti, F., Ridouani, F., Rogan, C., Ronellenfitsch, U., Ryan, S., Sallemi, C., Moragues, J. Sampere, Sandström, P., Sarriá, L., Schnitzbauer, A., Serenari, M., Serrablo, A., Smits, M. L. J., Sparrelid, E., Spüntrup, E., Stavrou, G. A., Sutcliffe, R. P., Tancredi, I., Tasse, J. C., Udupa, V., Valenti, D., Fundora, Y., Vogl, T. J., Wang, X., White, S. A., Wohlgemuth, W. A., Yu, D., Zijlstra, I. A. J., Binkert, C. A., Bemelmans, M. H. A., van der Leij, C., Schadde, E., and van Dam, R. M.

Published
2022
Full Text
View/download PDF

20. Dynamic surgical anatomy using 3D reconstruction technology in complex hepato-biliary surgery with vascular involvement. Results from an international multicentric survey

Author

Cotsoglou, C, Granieri, S, Bassetto, S, Bagnardi, V, Pugliese, R, Grazi, G, Guglielmi, A, Ruzzenente, A, Aldrighetti, L, Ratti, F, De Carlis, L, De Carlis, R, Centonze, L, De Angelis, N, Memeo, R, Delvecchio, A, Felli, E, Izzo, F, Belli, A, Patrone, R, Ettorre, G, Berardi, G, Di Benedetto, F, Di Sandro, S, Romano, F, Garancini, M, Scotti, M, Bianchi, G, Germini, A, Gjoni, E, Bonomi, A, Bruno, F, Paleino, S, Pugliese, G, Cotsoglou C., Granieri S., Bassetto S., Bagnardi V., Pugliese R., Grazi G. L., Guglielmi A., Ruzzenente A., Aldrighetti L., Ratti F., De Carlis L., De Carlis R., Centonze L., De Angelis N., Memeo R., Delvecchio A., Felli E., Izzo F., Belli A., Patrone R., Ettorre G. M., Berardi G., Di Benedetto F., Di Sandro S., Romano F., Garancini M., Scotti M. A., Bianchi G., Germini A., Gjoni E., Bonomi A., Bruno F., Paleino S., Pugliese G., Cotsoglou, C, Granieri, S, Bassetto, S, Bagnardi, V, Pugliese, R, Grazi, G, Guglielmi, A, Ruzzenente, A, Aldrighetti, L, Ratti, F, De Carlis, L, De Carlis, R, Centonze, L, De Angelis, N, Memeo, R, Delvecchio, A, Felli, E, Izzo, F, Belli, A, Patrone, R, Ettorre, G, Berardi, G, Di Benedetto, F, Di Sandro, S, Romano, F, Garancini, M, Scotti, M, Bianchi, G, Germini, A, Gjoni, E, Bonomi, A, Bruno, F, Paleino, S, Pugliese, G, Cotsoglou C., Granieri S., Bassetto S., Bagnardi V., Pugliese R., Grazi G. L., Guglielmi A., Ruzzenente A., Aldrighetti L., Ratti F., De Carlis L., De Carlis R., Centonze L., De Angelis N., Memeo R., Delvecchio A., Felli E., Izzo F., Belli A., Patrone R., Ettorre G. M., Berardi G., Di Benedetto F., Di Sandro S., Romano F., Garancini M., Scotti M. A., Bianchi G., Germini A., Gjoni E., Bonomi A., Bruno F., Paleino S., and Pugliese G.

Abstract

Introduction: Three-dimensional liver modeling can lead to substantial changes in choosing the type and extension of liver resection. This study aimed to explore whether 3D reconstruction helps to better understand the relationship between liver tumors and neighboring vascular structures compared to standard 2D CT scan images. Methods: Contrast-enhanced CT scan images of 11 patients suffering from primary and secondary hepatic tumors were selected. Twenty-three experienced HBP surgeons participated to the survey. A standardized questionnaire outlining 16 different vascular structures (items) having a potential relationship with the tumor was provided. Intraoperative and histopathological findings were used as the reference standard. The proper hypothesis was that 3D accuracy is greater than 2D. As a secondary endpoint, inter-raters’ agreement was explored. Results: The mean difference between 3D and 2D, was 2.6 points (SE: 0.40; 95 % CI: 1.7–3.5; p < 0.0001). After sensitivity analysis, the results favored 3D visualization as well (mean difference 1.7 points; SE: 0.32; 95 % CI: 1.0–2.5; p = 0.0004). The inter-raters’ agreement was moderate for both methods (2D: W = 0.45; 3D: W = 0.44). Conclusion: 3D reconstruction may give a significant contribution to better understanding liver vascular anatomy and the precise relationship between the tumor and the neighboring structures.

Published
2024

21. Atezolizumab plus bevacizumab versus lenvatinib or sorafenib in non-viral unresectable hepatocellular carcinoma: an international propensity score matching analysis

Author

Rimini, M., Rimassa, L., Ueshima, K., Burgio, V., Shigeo, S., Tada, T., Suda, G., Yoo, C., Cheon, J., Pinato, D.J., Lonardi, S., Scartozzi, M., Iavarone, M., Di Costanzo, G.G., Marra, F., Soldà, C., Tamburini, E., Piscaglia, F., Masi, G., Cabibbo, G., Foschi, F.G., Silletta, M., Pressiani, T., Nishida, N., Iwamoto, H., Sakamoto, N., Ryoo, B.-Y., Chon, H.J., Claudia, F., Niizeki, T., Sho, T., Kang, B., D’Alessio, A., Kumada, T., Hiraoka, A., Hirooka, M., Kariyama, K., Tani, J., Atsukawa, M., Takaguchi, K., Itobayashi, E., Fukunishi, S., Tsuji, K., Ishikawa, T., Tajiri, K., Ochi, H., Yasuda, S., Toyoda, H., Ogawa, C., Nishimur, T., Hatanaka, T., Kakizaki, S., Shimada, N., Kawata, K., Tanaka, T., Ohama, H., Nouso, K., Morishita, A., Tsutsui, A., Nagano, T., Itokawa, N., Okubo, T., Arai, T., Imai, M., Naganuma, A., Koizumi, Y., Nakamura, S., Joko, K., Iijima, H., Hiasa, Y., Pedica, F., De Cobelli, F., Ratti, F., Aldrighetti, L., Kudo, M., Cascinu, S., and Casadei-Gardini, A.

Published
2022
Full Text
View/download PDF

22. Real-Life Clinical Data of Lenvatinib versus Sorafenib for Unresectable Hepatocellular Carcinoma in Italy

Author

Burgio V, Iavarone M, Di Costanzo GG, Marra F, Lonardi S, Tamburini E, Piscaglia F, Masi G, Celsa C, Foschi FG, Silletta M, Amoruso DC, Rimini M, Bruccoleri M, Tortora R, Campani C, Soldà C, Viola MG, Forgione A, Conti F, Salani F, Catanese S, Giacchetto CM, Fulgenzi C, Coppola C, Lampertico P, Pellino A, Rancatore G, Cabibbo G, Ratti F, Pedica F, Della Corte A, Colombo M, De Cobelli F, Aldrighetti L, Cascinu S, and Casadei-Gardini A

Subjects
hepatocarcinoma, sorafenib, lenvatinib, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Valentina Burgio,1 Massimo Iavarone,2 Giovanni Giuseppe Di Costanzo,3 Fabio Marra,4 Sara Lonardi,5,6 Emiliano Tamburini,7 Fabio Piscaglia,8 Gianluca Masi,9,10 Ciro Celsa,11 Francesco Giuseppe Foschi,12 Marianna Silletta,13 Daniela Caterina Amoruso,14 Margherita Rimini,15 Mariangela Bruccoleri,2 Raffaella Tortora,3 Claudia Campani,4 Caterina Soldà,6 Massimo Giuseppe Viola,16 Antonella Forgione,8 Fabio Conti,12 Francesca Salani,9,10 Silvia Catanese,9,10 Carmelo Marco Giacchetto,17 Claudia Fulgenzi,13 Carmine Coppola,14 Pietro Lampertico,18 Antonio Pellino,6,19 Gabriele Rancatore,17 Giuseppe Cabibbo,17 Francesca Ratti,20 Federica Pedica,21 Angelo Della Corte,22 Massimo Colombo,18 Francesco De Cobelli,23 Luca Aldrighetti,20 Stefano Cascinu,1,23 Andrea Casadei-Gardini1,23 1Department of Medical Oncology, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan, 20132, Italy; 2Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Division of Gastroenterology and Hepatology, Milan, Italy; 3Department of Hepatology, Naples, 80131, Italy; 4Dipartimento di Medicina Sperimentale e Clinica, Università di Firenze, Firenze, Italy; 5Early Phase Clinical Trial Unit, Department of Oncology, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy; 6Medical Oncology Unit 1, Department of Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy; 7Department of Oncology and Palliative Care, Cardinale Hospital, Naples, Italy; 8Division of Internal Medicine, Hepatobiliary and Immunoallergic Disease, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 9Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy; 10Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; 11Department of Surgical, Oncological and Oral Sciences (Di.Chir.On.S.), University of Palermo, Palermo, 90127, Italy; 12Internal Medicine, Infermi Hospital, Faenza (AUSL ROMAGNA), Ravenna, Italy; 13Department of Oncology, Campus Bio Medico, Roma, Italy; 14Hepatology Unit, Internal Medicine, Area Stabiese Hospital, Naples, Italy; 15Department of Oncology and Hematology, Division of Oncology, University of Modena and Reggio Emilia, Modena, 4121, Italy; 16Department of General Surgery and Emergency Surgery, Cardinale Hospital, Tricase, Italy; 17Section of Gastroenterology & Hepatology, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, PROMISE, University of Palermo, Palermo, 90127, Italy; 18Liver Center, IRCCS San Raffaele Scientific Institute, Milan, 20132, Italy; 19Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy; 20Hepatobiliary Surgery Division, Liver Center, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan, 20132, Italy; 21Department of Experimental Oncology, Pathology Unit, IRCCS San Raffaele Scientific Institute, Milan, 20132, Italy; 22Department of Radiology, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan, 20132, Italy; 23School of Medicine, Vita-Salute San Raffaele University, Milan, 20132, ItalyCorrespondence: Andrea Casadei-GardiniDepartment of Medical Oncology, IRCCS San Raffaele Hospital, Via Olgettina n. 60, Milan, ItalyEmail casadeigardini@gmail.comBackground: Lenvatinib has been approved in Italy since October 2019 as a first-line therapy for advanced hepatocellular carcinoma (HCC) and to date data on effectiveness and safety of lenvatinib are not available in our region. To fill this gap, we performed a multicentric analysis of the real-world treatment outcomes with the propensity score matching in a cohort of Italian patients with unresectable HCC who were treated with either sorafenib or lenvatinib.Aims and Methods: To evaluate the effectiveness of sorafenib and lenvatinib as primary treatment of advanced HCC in clinical practice we performed a multicentric analysis of the treatment outcomes of 288 such patients recruited in 11 centers in Italy. A propensity score was used to mitigate confounding due to referral biases in the assessment of mortality and progression-free survival.Results: Over a follow-up period of 11 months the Cox regression model showed 48% reduction of death risk for patients treated with lenvatinib (95% CI: 0.34– 0.81; p = 0.0034), compared with those treated with sorafenib. The median PFS was 9.0 and 4.9 months for lenvatinib and sorafenib arm, respectively. Patients treated with lenvatinib showed a higher percentage of response rate (29.4% vs 2.8%; p < 0.00001) compared with patients treated with sorafenib. Sorafenib was shown to be correlated with more HFSR, diarrhea and fatigue, while lenvatinib with more hypertension and fatigue.Conclusion: Our study highlighted for the first time the efficacy and safety of lenvatinib in an Italian cohort of patients.Keywords: hepatocarcinoma, sorafenib, lenvatinib

Published
2021

23. Nonalcoholic steatohepatitis in hepatocarcinoma: new insights about its prognostic role in patients treated with lenvatinib

Author

Rimini, M., Kudo, M., Tada, T., Shigeo, S., Kang, W., Suda, G., Jefremow, A., Burgio, V., Iavarone, M., Tortora, R., Marra, F., Lonardi, S., Tamburini, E., Piscaglia, F., Masi, G., Cabibbo, G., Foschi, F.G., Silletta, M., Kumada, T., Iwamoto, H., Aoki, T., Goh, M.J., Sakamoto, N., Siebler, J., Hiraoka, A., Niizeki, T., Ueshima, K., Sho, T., Atsukawa, M., Hirooka, M., Tsuji, K., Ishikawa, T., Takaguchi, K., Kariyama, K., Itobayashi, E., Tajiri, K., Shimada, N., Shibata, H., Ochi, H., Yasuda, S., Toyoda, H., Fukunishi, S., Ohama, H., Kawata, K., Tani, J., Nakamura, S., Nouso, K., Tsutsui, A., Nagano, T., Takaaki, T., Itokawa, N., Okubo, T., Arai, T., Imai, M., Joko, K., Koizumi, Y., Hiasa, Y., Cucchetti, A., Ratti, F., Aldrighetti, L., Cascinu, S., and Casadei-Gardini, A.

Published
2021
Full Text
View/download PDF

24. Outcome after resection for perihilar cholangiocarcinoma in patients with primary sclerosing cholangitis: an international multicentre study

Author

Andreou, A., Bartsch, F., Benzing, C., Buettner, S., Capobianco, I., Charco, R., de Reuver, P.R., de Savornin Lohman, E., Dejong, C.H.C., Efanov, M., Erdmann, J.I., Franken, L.C., Giglio, M.C., Gomez-Gavara, C., Hagendoorn, J., Heid, F., IJzermans, J.N.M., Kazemier, G., Maithel, S.K., Malago, M., Malik, H.Z., Molenaar, Q.I., Muiesan, P., Nooijen, L.E., Nota, C.L.M., Olde Damink, S.W.M., Pratschke, J., Quinn, L.M., Ratti, F., Ravaioli, M., Roberts, K.J., Rolinger, J., Ruzzenente, A., Schadde, E., Schmelzle, M., Serenari, M., Sultana, A., van Laarhoven, S., van Vugt, J.L.A., Zonderhuis, B.M., Jansson, Hannes, Olthof, Pim B., Bergquist, Annika, Ligthart, Marjolein A.P., Nadalin, Silvio, Troisi, Roberto I., Groot Koerkamp, Bas, Alikhanov, Ruslan, Lang, Hauke, Guglielmi, Alfredo, Cescon, Matteo, Jarnagin, William R., Aldrighetti, Luca, van Gulik, Thomas M., and Sparrelid, Ernesto

Published
2021
Full Text
View/download PDF

27. The CHEOPS mission

Author

Benz, W., Broeg, C., Fortier, A., Rando, N., Beck, T., Beck, M., Queloz, D., Ehrenreich, D., Maxted, P. F. L., Isaak, K. G., Billot, N., Alibert, Y., Alonso, R., António, C., Asquier, J., Bandy, T., Bárczy, T., Barrado, D., Barros, S. C. C., Baumjohann, W., Bekkelien, A., Bergomi, M., Biondi, F., Bonfils, X., Borsato, L., Brandeker, A., Busch, M.-D., Cabrera, J., Cessa, V., Charnoz, S., Chazelas, B., Collier Cameron, A., Corral Van Damme, C., Cortes, D., Davies, M. B., Deleuil, M., Deline, A., Delrez, L., Demangeon, O., Demory, B. O., Erikson, A., Farinato, J., Fossati, L., Fridlund, M., Futyan, D., Gandolfi, D., Garcia Munoz, A., Gillon, M., Guterman, P., Gutierrez, A., Hasiba, J., Heng, K., Hernandez, E., Hoyer, S., Kiss, L. L., Kovacs, Z., Kuntzer, T., Laskar, J., Lecavelier des Etangs, A., Lendl, M., López, A., Lora, I., Lovis, C., Lüftinger, T., Magrin, D., Malvasio, L., Marafatto, L., Michaelis, H., de Miguel, D., Modrego, D., Munari, M., Nascimbeni, V., Olofsson, G., Ottacher, H., Ottensamer, R., Pagano, I., Palacios, R., Pallé, E., Peter, G., Piazza, D., Piotto, G., Pizarro, A., Pollaco, D., Ragazzoni, R., Ratti, F., Rauer, H., Ribas, I., Rieder, M., Rohlfs, R., Safa, F., Salatti, M., Santos, N. C., Scandariato, G., Ségransan, D., Simon, A. E., Smith, A. M. S., Sordet, M., Sousa, S. G., Steller, M., Szabó, G. M., Szoke, J., Thomas, N., Tschentscher, M., Udry, S., Van Grootel, V., Viotto, V., Walter, I., Walton, N. A., Wildi, F., and Wolter, D.

Published
2021
Full Text
View/download PDF

28. Antihypertensive treatment changes and related clinical outcomes in older hospitalized patients

Author

Cicco, S, D'Abbondanza, M, Proietti, M, Zaccone, V, Pes, C, Caradio, F, Mattioli, M, Piano, S, Marra, A, Nobili, A, Mannucci, P, Pietrangelo, A, Sesti, G, Buzzetti, E, Salzano, A, Cimellaro, A, Perticone, F, Violi, F, Corazza, G, Corrao, S, Marengoni, A, Salerno, F, Cesari, M, Tettamanti, M, Pasina, L, Franchi, C, Novella, A, Miglio, G, Galbussera, A, Ardoino, I, Prisco, D, Silvestri, E, Emmi, G, Bettiol, A, Mattioli, I, Biolo, G, Zanetti, M, Bartelloni, G, Zaccari, M, Chiuch, M, Vanoli, M, Grignani, G, Pulixi, E, Pirro, M, Lupattelli, G, Bianconi, V, Alcidi, R, Giotta, A, Mannarino, M, Girelli, D, Busti, F, Marchi, G, Barbagallo, M, Dominguez, L, Beneduce, V, Cacioppo, F, Natoli, G, Mularo, S, Raspanti, M, Argano, C, Cavallaro, F, Zoli, M, Matacena, M, Orio, G, Magnolfi, E, Serafini, G, Simili, A, Brunori, M, Lazzari, I, Cappellini, M, Fabio, G, De Amicis, M, De Luca, G, Scaramellini, N, Di Stefano, V, Leoni, S, Seghezzi, S, Di Mauro, A, Maira, D, Mancarella, M, Lucchi, T, Rossi, P, Clerici, M, Bonini, G, Conti, F, Prolo, S, Fabrizi, M, Martelengo, M, Vigani, G, Di Sabatino, A, Miceli, E, Lenti, M, Pisati, M, Pitotti, L, Padula, D, Antoci, V, Cambie, G, Pontremoli, R, Beccati, V, Nobili, G, Leoncini, G, Alberto, J, Cattaneo, F, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Guagnano, M, Rossi, I, Valeriani, E, D'Ardes, D, Esposito, L, Sestili, S, Angelucci, E, Mancuso, G, Calipari, D, Bartone, M, Delitala, G, Berria, M, Delitala, A, Muscaritoli, M, Molfino, A, Petrillo, E, Giorgi, A, Gracin, C, Imbimbo, G, Zuccala, G, D'Aurizio, G, Romanelli, G, Volpini, A, Lucente, D, Manzoni, F, Pirozzi, A, Zucchelli, A, Picardi, A, Gentilucci, U, Gallo, P, Dell'Unto, C, Bellelli, G, Corsi, M, Antonucci, C, Sidoli, C, Principato, G, Bonfanti, A, Szabo, H, Mazzola, P, Piazzoli, A, Arturi, F, Succurro, E, Tassone, B, Giofre, F, Serra, M, Bleve, M, Brucato, A, De Falco, T, Negro, E, Brenna, M, Trotta, L, Squintani, G, Randi, M, Fabris, F, Bertozzi, I, Bogoni, G, Rabuini, M, Prandini, T, Ratti, F, Zurlo, C, Cerruti, L, Cosi, E, Manfredini, R, Fabbian, F, Boari, B, De Giorgi, A, Tiseo, R, Paolisso, G, Rizzo, M, Catalano, C, Di Meo, I, Borghi, C, Strocchi, E, Ianniello, E, Soldati, M, Schiavone, S, Bragagni, A, Leoni, F, De Sando, V, Scarduelli, S, Cammarosano, M, Pareo, I, Sabba, C, Vella, F, Suppressa, P, De Vincenzo, G, Comitangelo, A, Amoruso, E, Custodero, C, Re, G, Schilardi, A, Loparco, F, Fenoglio, L, Falcetta, A, Giraudo, A, D'Aniano, S, Fracanzani, A, Tiraboschi, S, Cespiati, A, Oberti, G, Sigon, G, Cinque, F, Peyvandi, F, Rossio, R, Colombo, G, Agosti, P, Pagliaro, E, Semproni, E, Ciro, C, Monzani, V, Savojardo, V, Ceriani, G, Folli, C, Pallini, G, Montecucco, F, Ottonello, L, Caserza, L, Vischi, G, Kassem, S, Liberale, L, Liberato, N, Tognin, T, Purrello, F, Di Pino, A, Piro, S, Rozzini, R, Falanga, L, Pisciotta, M, Bellucci, F, Buffelli, S, Ferrandina, C, Mazzeo, F, Spazzini, E, Cono, G, Cesaroni, G, Montrucchio, G, Peasso, P, Favale, E, Poletto, C, Margaria, C, Sanino, M, Perri, L, Guasti, L, Rotunno, F, Castiglioni, L, Maresca, A, Squizzato, A, Campiotti, L, Grossi, A, Diprizio, R, Dentali, F, Bertolotti, M, Mussi, C, Lancellotti, G, Libbra, M, Galassi, M, Grassi, Y, Greco, A, Bigi, E, Pellegrini, E, Orlandi, L, Dondi, G, Carulli, L, Sciacqua, A, Perticone, M, Battaglia, R, Maio, R, Scozzafava, A, Condoleo, V, Falbo, T, Colangelo, L, Filice, M, Clausi, E, Stanghellini, V, Ruggeri, E, del Vecchio, S, Benzoni, I, Salvi, A, Leonardi, R, Damiani, G, Moroncini, G, Capeci, W, Martino, G, Biondi, L, Pettinari, P, Ormas, M, Filippini, E, Benfaremo, D, Romiti, R, Ghio, R, Col, A, Minisola, S, Cilli, M, Labbadia, G, Afeltra, A, Marigliano, B, Pipita, M, Castellino, P, Zanoli, L, Gennaro, A, Gaudio, A, Pignataro, S, Mete, F, Gino, M, Moreo, G, Pina, G, Ballestrero, A, Ferrando, F, Gonella, R, Cerminara, D, Setti, P, Traversa, C, Scarsi, C, Graziella, B, Baldassarre, S, Fragapani, S, Gruden, G, Berti, F, Famularo, G, Tarsitani, P, Castello, R, Pasino, M, Maggio, M, Ceda, G, Morganti, S, Artoni, A, Grossi, M, Del Giacco, S, Firinu, D, Costanzo, G, Argiolas, G, Paoletti, G, Losa, F, Montalto, G, Licata, A, Montalto, F, Corica, F, Basile, G, Catalano, A, Bellone, F, Principato, C, Malatino, L, Stancanelli, B, Terranova, V, Di Marca, S, Di Quattro, R, La Malfa, L, Caruso, R, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Ticinesi, A, Nouvenne, A, Minuz, P, Fondrieschi, L, Imperiale, G, Morellini, S, Pirisi, M, Fra, G, Sola, D, Bellan, M, Quadri, R, Larovere, E, Novelli, M, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Napoli, F, Aiello, I, Salvatore, T, Monaco, L, Ricozzi, C, Pilotto, A, Indiano, I, Gandolfo, F, Pasini, F, Capecchi, P, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Bernardi, M, Bassi, S, Santi, L, Zaccherini, G, Durante, V, Tirotta, D, Eusebi, G, Cattaneo, M, Amoruso, M, Fracasso, P, Fasolino, C, Tresoldi, M, Bozzolo, E, Damanti, S, Porta, M, Armentaro, G, Arnone, M, Barone, M, Bertolino, L, Bianco, S, Binello, N, Brancati, S, Buonauro, A, Cordeddu, W, Curcio, R, Dalbeni, A, D'Agnano, S, De Feo, M, Donnarumma, E, Fei, M, Gambino, C, Giorgini, P, Lombardi, R, Miceli, G, Naccarato, P, Noviello, S, Olivieri, G, Parente, R, Pignataro, F, Poma, S, Porceddu, E, Pucci, G, Ricchio, M, Sabena, A, Salice, M, Santarossa, C, Savona, A, Savrie, C, Scicali, R, Stabile, M, Talerico, G, Talia, M, Tassone, E, Teatini, T, Tombolini, E, Traversa, M, Vettore, E, Vignal, A, Vilardi, L, Villani, R, Vitale, F, Cicco S., D'Abbondanza M., Proietti M., Zaccone V., Pes C., Caradio F., Mattioli M., Piano S., Marra A. M., Nobili A., Mannucci P. M., Pietrangelo A., Sesti G., Buzzetti E., Salzano A., Cimellaro A., Perticone F., Violi F., Corazza G. R., Corrao S., Marengoni A., Salerno F., Cesari M., Tettamanti M., Pasina L., Franchi C., Novella A., Miglio G., Galbussera A. A., Ardoino I., Prisco D., Silvestri E., Emmi G., Bettiol A., Mattioli I., Biolo G., Zanetti M., Bartelloni G., Zaccari M., Chiuch M., Vanoli M., Grignani G., Pulixi E. A., Pirro M., Lupattelli G., Bianconi V., Alcidi R., Giotta A., Mannarino M. R., Girelli D., Busti F., Marchi G., Barbagallo M., Dominguez L., Beneduce V., Cacioppo F., Natoli G., Mularo S., Raspanti M., Argano C., Cavallaro F., Zoli M., Matacena M. L., Orio G., Magnolfi E., Serafini G., Simili A., Brunori M., Lazzari I., Cappellini M. D., Fabio G., De Amicis M. M., De Luca G., Scaramellini N., Di Stefano V., Leoni S., Seghezzi S., Di Mauro A. D., Maira D., Mancarella M., Lucchi T., Rossi P. D., Clerici M., Bonini G., Conti F., Prolo S., Fabrizi M., Martelengo M., Vigani G., Di Sabatino A., Miceli E., Lenti M. V., Pisati M., Pitotti L., Padula D., Antoci V., Cambie G., Pontremoli R., Beccati V., Nobili G., Leoncini G., Alberto J., Cattaneo F., Anastasio L., Sofia L., Carbone M., Cipollone F., Guagnano M. T., Rossi I., Valeriani E., D'Ardes D., Esposito L., Sestili S., Angelucci E., Mancuso G., Calipari D., Bartone M., Delitala G., Berria M., Delitala A., Muscaritoli M., Molfino A., Petrillo E., Giorgi A., Gracin C., Imbimbo G., Zuccala G., D'Aurizio G., Romanelli G., Volpini A., Lucente D., Manzoni F., Pirozzi A., Zucchelli A., Picardi A., Gentilucci U. V., Gallo P., Dell'Unto C., Bellelli G., Corsi M., Antonucci C., Sidoli C., Principato G., Bonfanti A., Szabo H., Mazzola P., Piazzoli A., Arturi F., Succurro E., Tassone B., Giofre F., Serra M. G., Bleve M. A., Brucato A., De Falco T., Negro E., Brenna M., Trotta L., Squintani G. L., Randi M. L., Fabris F., Bertozzi I., Bogoni G., Rabuini M. V., Prandini T., Ratti F., Zurlo C., Cerruti L., Cosi E., Manfredini R., Fabbian F., Boari B., De Giorgi A., Tiseo R., Paolisso G., Rizzo M. R., Catalano C., Di Meo I., Borghi C., Strocchi E., Ianniello E., Soldati M., Schiavone S., Bragagni A., Leoni F. G., De Sando V., Scarduelli S., Cammarosano M., Pareo I., Sabba C., Vella F. S., Suppressa P., De Vincenzo G. M., Comitangelo A., Amoruso E., Custodero C., Re G., Schilardi A., Loparco F., Fenoglio L., Falcetta A., Giraudo A. V., D'Aniano S., Fracanzani A. L., Tiraboschi S., Cespiati A., Oberti G., Sigon G., Cinque F., Peyvandi F., Rossio R., Colombo G., Agosti P., Pagliaro E., Semproni E., Ciro C., Monzani V., Savojardo V., Ceriani G., Folli C., Pallini G., Montecucco F., Ottonello L., Caserza L., Vischi G., Kassem S., Liberale L., Liberato N. L., Tognin T., Purrello F., Di Pino A., Piro S., Rozzini R., Falanga L., Pisciotta M. S., Bellucci F. B., Buffelli S., Ferrandina C., Mazzeo F., Spazzini E., Cono G., Cesaroni G., Montrucchio G., Peasso P., Favale E., Poletto C., Margaria C., Sanino M., Perri L., Guasti L., Rotunno F., Castiglioni L., Maresca A., Squizzato A., Campiotti L., Grossi A., Diprizio R. D., Dentali F., Bertolotti M., Mussi C., Lancellotti G., Libbra M. V., Galassi M., Grassi Y., Greco A., Bigi E., Pellegrini E., Orlandi L., Dondi G., Carulli L., Sciacqua A., Perticone M., Battaglia R., Maio R., Scozzafava A., Condoleo V., Falbo T., Colangelo L., Filice M., Clausi E., Stanghellini V., Ruggeri E., del Vecchio S., Benzoni I., Salvi A., Leonardi R., Damiani G., Moroncini G., Capeci W., Martino G. P., Biondi L., Pettinari P., Ormas M., Filippini E., Benfaremo D., Romiti R., Ghio R., Col A. D., Minisola S., Cilli M., Labbadia G., Afeltra A., Marigliano B., Pipita M. E., Castellino P., Zanoli L., Gennaro A., Gaudio A., Pignataro S., Mete F., Gino M., Moreo G., Pina G., Ballestrero A., Ferrando F., Gonella R., Cerminara D., Setti P., Traversa C., Scarsi C., Graziella B., Baldassarre S., Fragapani S., Gruden G., Berti F., Famularo G., Tarsitani P., Castello R., Pasino M., Maggio M. G., Ceda G. P., Morganti S., Artoni A., Grossi M., Del Giacco S., Firinu D., Costanzo G., Argiolas G., Paoletti G., Losa F., Montalto G., Licata A., Montalto F. A., Corica F., Basile G., Catalano A., Bellone F., Principato C., Malatino L., Stancanelli B., Terranova V., Di Marca S., Di Quattro R., La Malfa L., Caruso R., Mecocci P., Ruggiero C., Boccardi V., Meschi T., Ticinesi A., Nouvenne A., Minuz P., Fondrieschi L., Imperiale G. N., Morellini S., Pirisi M., Fra G. P., Sola D., Bellan M., Quadri R., Larovere E., Novelli M., Simeone E., Scurti R., Tolloso F., Tarquini R., Valoriani A., Dolenti S., Vannini G., Volpi R., Bocchi P., Vignali A., Harari S., Lonati C., Napoli F., Aiello I., Salvatore T., Monaco L., Ricozzi C., Pilotto A., Indiano I., Gandolfo F., Pasini F. L., Capecchi P. L., Nuti R., Valenti R., Ruvio M., Cappelli S., Palazzuoli A., Bernardi M., Bassi S. L., Santi L., Zaccherini G., Durante V., Tirotta D., Eusebi G., Cattaneo M., Amoruso M. V., Fracasso P., Fasolino C., Tresoldi M., Bozzolo E., Damanti S., Porta M., Armentaro G., Arnone M. I., Barone M., Bertolino L., Bianco S., Binello N., Brancati S., Buonauro A., Cordeddu W., Curcio R., Dalbeni A., D'Agnano S., De Feo M., Donnarumma E., Fei M., Gambino C. G., Giorgini P., Lombardi R., Miceli G., Naccarato P., Noviello S., Olivieri G., Parente R., Pignataro F. S., Poma S., Porceddu E., Pucci G., Ricchio M., Sabena A., Salice M., Santarossa C., Savona A., Savrie C., Scicali R., Stabile M., Talerico G., Talia M., Tassone E. J., Teatini T., Tombolini E., Traversa M., Vettore E., Vignal A., Vilardi L., Villani R., Vitale F., Cicco, S, D'Abbondanza, M, Proietti, M, Zaccone, V, Pes, C, Caradio, F, Mattioli, M, Piano, S, Marra, A, Nobili, A, Mannucci, P, Pietrangelo, A, Sesti, G, Buzzetti, E, Salzano, A, Cimellaro, A, Perticone, F, Violi, F, Corazza, G, Corrao, S, Marengoni, A, Salerno, F, Cesari, M, Tettamanti, M, Pasina, L, Franchi, C, Novella, A, Miglio, G, Galbussera, A, Ardoino, I, Prisco, D, Silvestri, E, Emmi, G, Bettiol, A, Mattioli, I, Biolo, G, Zanetti, M, Bartelloni, G, Zaccari, M, Chiuch, M, Vanoli, M, Grignani, G, Pulixi, E, Pirro, M, Lupattelli, G, Bianconi, V, Alcidi, R, Giotta, A, Mannarino, M, Girelli, D, Busti, F, Marchi, G, Barbagallo, M, Dominguez, L, Beneduce, V, Cacioppo, F, Natoli, G, Mularo, S, Raspanti, M, Argano, C, Cavallaro, F, Zoli, M, Matacena, M, Orio, G, Magnolfi, E, Serafini, G, Simili, A, Brunori, M, Lazzari, I, Cappellini, M, Fabio, G, De Amicis, M, De Luca, G, Scaramellini, N, Di Stefano, V, Leoni, S, Seghezzi, S, Di Mauro, A, Maira, D, Mancarella, M, Lucchi, T, Rossi, P, Clerici, M, Bonini, G, Conti, F, Prolo, S, Fabrizi, M, Martelengo, M, Vigani, G, Di Sabatino, A, Miceli, E, Lenti, M, Pisati, M, Pitotti, L, Padula, D, Antoci, V, Cambie, G, Pontremoli, R, Beccati, V, Nobili, G, Leoncini, G, Alberto, J, Cattaneo, F, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Guagnano, M, Rossi, I, Valeriani, E, D'Ardes, D, Esposito, L, Sestili, S, Angelucci, E, Mancuso, G, Calipari, D, Bartone, M, Delitala, G, Berria, M, Delitala, A, Muscaritoli, M, Molfino, A, Petrillo, E, Giorgi, A, Gracin, C, Imbimbo, G, Zuccala, G, D'Aurizio, G, Romanelli, G, Volpini, A, Lucente, D, Manzoni, F, Pirozzi, A, Zucchelli, A, Picardi, A, Gentilucci, U, Gallo, P, Dell'Unto, C, Bellelli, G, Corsi, M, Antonucci, C, Sidoli, C, Principato, G, Bonfanti, A, Szabo, H, Mazzola, P, Piazzoli, A, Arturi, F, Succurro, E, Tassone, B, Giofre, F, Serra, M, Bleve, M, Brucato, A, De Falco, T, Negro, E, Brenna, M, Trotta, L, Squintani, G, Randi, M, Fabris, F, Bertozzi, I, Bogoni, G, Rabuini, M, Prandini, T, Ratti, F, Zurlo, C, Cerruti, L, Cosi, E, Manfredini, R, Fabbian, F, Boari, B, De Giorgi, A, Tiseo, R, Paolisso, G, Rizzo, M, Catalano, C, Di Meo, I, Borghi, C, Strocchi, E, Ianniello, E, Soldati, M, Schiavone, S, Bragagni, A, Leoni, F, De Sando, V, Scarduelli, S, Cammarosano, M, Pareo, I, Sabba, C, Vella, F, Suppressa, P, De Vincenzo, G, Comitangelo, A, Amoruso, E, Custodero, C, Re, G, Schilardi, A, Loparco, F, Fenoglio, L, Falcetta, A, Giraudo, A, D'Aniano, S, Fracanzani, A, Tiraboschi, S, Cespiati, A, Oberti, G, Sigon, G, Cinque, F, Peyvandi, F, Rossio, R, Colombo, G, Agosti, P, Pagliaro, E, Semproni, E, Ciro, C, Monzani, V, Savojardo, V, Ceriani, G, Folli, C, Pallini, G, Montecucco, F, Ottonello, L, Caserza, L, Vischi, G, Kassem, S, Liberale, L, Liberato, N, Tognin, T, Purrello, F, Di Pino, A, Piro, S, Rozzini, R, Falanga, L, Pisciotta, M, Bellucci, F, Buffelli, S, Ferrandina, C, Mazzeo, F, Spazzini, E, Cono, G, Cesaroni, G, Montrucchio, G, Peasso, P, Favale, E, Poletto, C, Margaria, C, Sanino, M, Perri, L, Guasti, L, Rotunno, F, Castiglioni, L, Maresca, A, Squizzato, A, Campiotti, L, Grossi, A, Diprizio, R, Dentali, F, Bertolotti, M, Mussi, C, Lancellotti, G, Libbra, M, Galassi, M, Grassi, Y, Greco, A, Bigi, E, Pellegrini, E, Orlandi, L, Dondi, G, Carulli, L, Sciacqua, A, Perticone, M, Battaglia, R, Maio, R, Scozzafava, A, Condoleo, V, Falbo, T, Colangelo, L, Filice, M, Clausi, E, Stanghellini, V, Ruggeri, E, del Vecchio, S, Benzoni, I, Salvi, A, Leonardi, R, Damiani, G, Moroncini, G, Capeci, W, Martino, G, Biondi, L, Pettinari, P, Ormas, M, Filippini, E, Benfaremo, D, Romiti, R, Ghio, R, Col, A, Minisola, S, Cilli, M, Labbadia, G, Afeltra, A, Marigliano, B, Pipita, M, Castellino, P, Zanoli, L, Gennaro, A, Gaudio, A, Pignataro, S, Mete, F, Gino, M, Moreo, G, Pina, G, Ballestrero, A, Ferrando, F, Gonella, R, Cerminara, D, Setti, P, Traversa, C, Scarsi, C, Graziella, B, Baldassarre, S, Fragapani, S, Gruden, G, Berti, F, Famularo, G, Tarsitani, P, Castello, R, Pasino, M, Maggio, M, Ceda, G, Morganti, S, Artoni, A, Grossi, M, Del Giacco, S, Firinu, D, Costanzo, G, Argiolas, G, Paoletti, G, Losa, F, Montalto, G, Licata, A, Montalto, F, Corica, F, Basile, G, Catalano, A, Bellone, F, Principato, C, Malatino, L, Stancanelli, B, Terranova, V, Di Marca, S, Di Quattro, R, La Malfa, L, Caruso, R, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Ticinesi, A, Nouvenne, A, Minuz, P, Fondrieschi, L, Imperiale, G, Morellini, S, Pirisi, M, Fra, G, Sola, D, Bellan, M, Quadri, R, Larovere, E, Novelli, M, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Napoli, F, Aiello, I, Salvatore, T, Monaco, L, Ricozzi, C, Pilotto, A, Indiano, I, Gandolfo, F, Pasini, F, Capecchi, P, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Bernardi, M, Bassi, S, Santi, L, Zaccherini, G, Durante, V, Tirotta, D, Eusebi, G, Cattaneo, M, Amoruso, M, Fracasso, P, Fasolino, C, Tresoldi, M, Bozzolo, E, Damanti, S, Porta, M, Armentaro, G, Arnone, M, Barone, M, Bertolino, L, Bianco, S, Binello, N, Brancati, S, Buonauro, A, Cordeddu, W, Curcio, R, Dalbeni, A, D'Agnano, S, De Feo, M, Donnarumma, E, Fei, M, Gambino, C, Giorgini, P, Lombardi, R, Miceli, G, Naccarato, P, Noviello, S, Olivieri, G, Parente, R, Pignataro, F, Poma, S, Porceddu, E, Pucci, G, Ricchio, M, Sabena, A, Salice, M, Santarossa, C, Savona, A, Savrie, C, Scicali, R, Stabile, M, Talerico, G, Talia, M, Tassone, E, Teatini, T, Tombolini, E, Traversa, M, Vettore, E, Vignal, A, Vilardi, L, Villani, R, Vitale, F, Cicco S., D'Abbondanza M., Proietti M., Zaccone V., Pes C., Caradio F., Mattioli M., Piano S., Marra A. M., Nobili A., Mannucci P. M., Pietrangelo A., Sesti G., Buzzetti E., Salzano A., Cimellaro A., Perticone F., Violi F., Corazza G. R., Corrao S., Marengoni A., Salerno F., Cesari M., Tettamanti M., Pasina L., Franchi C., Novella A., Miglio G., Galbussera A. A., Ardoino I., Prisco D., Silvestri E., Emmi G., Bettiol A., Mattioli I., Biolo G., Zanetti M., Bartelloni G., Zaccari M., Chiuch M., Vanoli M., Grignani G., Pulixi E. A., Pirro M., Lupattelli G., Bianconi V., Alcidi R., Giotta A., Mannarino M. R., Girelli D., Busti F., Marchi G., Barbagallo M., Dominguez L., Beneduce V., Cacioppo F., Natoli G., Mularo S., Raspanti M., Argano C., Cavallaro F., Zoli M., Matacena M. L., Orio G., Magnolfi E., Serafini G., Simili A., Brunori M., Lazzari I., Cappellini M. D., Fabio G., De Amicis M. M., De Luca G., Scaramellini N., Di Stefano V., Leoni S., Seghezzi S., Di Mauro A. D., Maira D., Mancarella M., Lucchi T., Rossi P. D., Clerici M., Bonini G., Conti F., Prolo S., Fabrizi M., Martelengo M., Vigani G., Di Sabatino A., Miceli E., Lenti M. V., Pisati M., Pitotti L., Padula D., Antoci V., Cambie G., Pontremoli R., Beccati V., Nobili G., Leoncini G., Alberto J., Cattaneo F., Anastasio L., Sofia L., Carbone M., Cipollone F., Guagnano M. T., Rossi I., Valeriani E., D'Ardes D., Esposito L., Sestili S., Angelucci E., Mancuso G., Calipari D., Bartone M., Delitala G., Berria M., Delitala A., Muscaritoli M., Molfino A., Petrillo E., Giorgi A., Gracin C., Imbimbo G., Zuccala G., D'Aurizio G., Romanelli G., Volpini A., Lucente D., Manzoni F., Pirozzi A., Zucchelli A., Picardi A., Gentilucci U. V., Gallo P., Dell'Unto C., Bellelli G., Corsi M., Antonucci C., Sidoli C., Principato G., Bonfanti A., Szabo H., Mazzola P., Piazzoli A., Arturi F., Succurro E., Tassone B., Giofre F., Serra M. G., Bleve M. A., Brucato A., De Falco T., Negro E., Brenna M., Trotta L., Squintani G. L., Randi M. L., Fabris F., Bertozzi I., Bogoni G., Rabuini M. V., Prandini T., Ratti F., Zurlo C., Cerruti L., Cosi E., Manfredini R., Fabbian F., Boari B., De Giorgi A., Tiseo R., Paolisso G., Rizzo M. R., Catalano C., Di Meo I., Borghi C., Strocchi E., Ianniello E., Soldati M., Schiavone S., Bragagni A., Leoni F. G., De Sando V., Scarduelli S., Cammarosano M., Pareo I., Sabba C., Vella F. S., Suppressa P., De Vincenzo G. M., Comitangelo A., Amoruso E., Custodero C., Re G., Schilardi A., Loparco F., Fenoglio L., Falcetta A., Giraudo A. V., D'Aniano S., Fracanzani A. L., Tiraboschi S., Cespiati A., Oberti G., Sigon G., Cinque F., Peyvandi F., Rossio R., Colombo G., Agosti P., Pagliaro E., Semproni E., Ciro C., Monzani V., Savojardo V., Ceriani G., Folli C., Pallini G., Montecucco F., Ottonello L., Caserza L., Vischi G., Kassem S., Liberale L., Liberato N. L., Tognin T., Purrello F., Di Pino A., Piro S., Rozzini R., Falanga L., Pisciotta M. S., Bellucci F. B., Buffelli S., Ferrandina C., Mazzeo F., Spazzini E., Cono G., Cesaroni G., Montrucchio G., Peasso P., Favale E., Poletto C., Margaria C., Sanino M., Perri L., Guasti L., Rotunno F., Castiglioni L., Maresca A., Squizzato A., Campiotti L., Grossi A., Diprizio R. D., Dentali F., Bertolotti M., Mussi C., Lancellotti G., Libbra M. V., Galassi M., Grassi Y., Greco A., Bigi E., Pellegrini E., Orlandi L., Dondi G., Carulli L., Sciacqua A., Perticone M., Battaglia R., Maio R., Scozzafava A., Condoleo V., Falbo T., Colangelo L., Filice M., Clausi E., Stanghellini V., Ruggeri E., del Vecchio S., Benzoni I., Salvi A., Leonardi R., Damiani G., Moroncini G., Capeci W., Martino G. P., Biondi L., Pettinari P., Ormas M., Filippini E., Benfaremo D., Romiti R., Ghio R., Col A. D., Minisola S., Cilli M., Labbadia G., Afeltra A., Marigliano B., Pipita M. E., Castellino P., Zanoli L., Gennaro A., Gaudio A., Pignataro S., Mete F., Gino M., Moreo G., Pina G., Ballestrero A., Ferrando F., Gonella R., Cerminara D., Setti P., Traversa C., Scarsi C., Graziella B., Baldassarre S., Fragapani S., Gruden G., Berti F., Famularo G., Tarsitani P., Castello R., Pasino M., Maggio M. G., Ceda G. P., Morganti S., Artoni A., Grossi M., Del Giacco S., Firinu D., Costanzo G., Argiolas G., Paoletti G., Losa F., Montalto G., Licata A., Montalto F. A., Corica F., Basile G., Catalano A., Bellone F., Principato C., Malatino L., Stancanelli B., Terranova V., Di Marca S., Di Quattro R., La Malfa L., Caruso R., Mecocci P., Ruggiero C., Boccardi V., Meschi T., Ticinesi A., Nouvenne A., Minuz P., Fondrieschi L., Imperiale G. N., Morellini S., Pirisi M., Fra G. P., Sola D., Bellan M., Quadri R., Larovere E., Novelli M., Simeone E., Scurti R., Tolloso F., Tarquini R., Valoriani A., Dolenti S., Vannini G., Volpi R., Bocchi P., Vignali A., Harari S., Lonati C., Napoli F., Aiello I., Salvatore T., Monaco L., Ricozzi C., Pilotto A., Indiano I., Gandolfo F., Pasini F. L., Capecchi P. L., Nuti R., Valenti R., Ruvio M., Cappelli S., Palazzuoli A., Bernardi M., Bassi S. L., Santi L., Zaccherini G., Durante V., Tirotta D., Eusebi G., Cattaneo M., Amoruso M. V., Fracasso P., Fasolino C., Tresoldi M., Bozzolo E., Damanti S., Porta M., Armentaro G., Arnone M. I., Barone M., Bertolino L., Bianco S., Binello N., Brancati S., Buonauro A., Cordeddu W., Curcio R., Dalbeni A., D'Agnano S., De Feo M., Donnarumma E., Fei M., Gambino C. G., Giorgini P., Lombardi R., Miceli G., Naccarato P., Noviello S., Olivieri G., Parente R., Pignataro F. S., Poma S., Porceddu E., Pucci G., Ricchio M., Sabena A., Salice M., Santarossa C., Savona A., Savrie C., Scicali R., Stabile M., Talerico G., Talia M., Tassone E. J., Teatini T., Tombolini E., Traversa M., Vettore E., Vignal A., Vilardi L., Villani R., and Vitale F.

Abstract

Background: Hypertension management in older patients represents a challenge, particularly when hospitalized. Objective: The objective of this study is to investigate the determinants and related outcomes of antihypertensive drug prescription in a cohort of older hospitalized patients. Methods: A total of 5671 patients from REPOSI (a prospective multicentre observational register of older Italian in-patients from internal medicine or geriatric wards) were considered; 4377 (77.2%) were hypertensive. Minimum treatment (MT) for hypertension was defined according to the 2018 ESC guidelines [an angiotensin-converting-enzyme-inhibitor (ACE-I) or an angiotensin-receptor-blocker (ARB) with a calcium-channel-blocker (CCB) and/or a thiazide diuretic; if >80 years old, an ACE-I or ARB or CCB or thiazide diuretic]. Determinants of MT discontinuation at discharge were assessed. Study outcomes were any cause rehospitalization/all cause death, all-cause death, cardiovascular (CV) hospitalization/death, CV death, non-CV death, evaluated according to the presence of MT at discharge. Results: Hypertensive patients were older than normotensives, with a more impaired functional status, higher burden of comorbidity and polypharmacy. A total of 2233 patients were on MT at admission, 1766 were on MT at discharge. Discontinuation of MT was associated with the presence of comorbidities (lower odds for diabetes, higher odds for chronic kidney disease and dementia). An adjusted multivariable logistic regression analysis showed that MT for hypertension at discharge was associated with lower risk of all-cause death, all-cause death/hospitalization, CV death, CV death/hospitalization and non-CV death. Conclusions: Guidelines-suggested MT for hypertension at discharge is associated with a lower risk of adverse clinical outcomes. Nevertheless, changes in antihypertensive treatment still occur in a significant proportion of older hospitalized patients.

Published
2023

29. Clinical features and outcomes of elderly hospitalised patients with chronic obstructive pulmonary disease, heart failure or both

Author

Crisafulli, E, Sartori, G, Vianello, A, Busti, F, Nobili, A, Mannucci, P, Girelli, D, Sesti, G, Pietrangelo, A, Perticone, F, Violi, F, Corrao, S, Marengoni, A, Tettamanti, M, Pasina, L, Franchi, C, Novella, A, Miglio, G, Galbussera, A, Ardoino, I, Prisco, D, Silvestri, E, Emmi, G, Bettiol, A, Mattioli, I, Biolo, G, Zanetti, M, Bartelloni, G, Zaccari, M, Chiuch, M, Vanoli, M, Grignani, G, Pulixi, E, Pirro, M, Lupattelli, G, Bianconi, V, Alcidi, R, Giotta, A, Mannarino, M, Marchi, G, Barbagallo, M, Dominguez, L, Beneduce, V, Cacioppo, F, Natoli, G, Mularo, S, Raspanti, M, Argano, C, Cavallaro, F, Zoli, M, Matacena, M, Orio, G, Magnolfi, E, Serafini, G, Simili, A, Brunori, M, Lazzari, I, Cappellini, M, Fabio, G, De Amicis, M, De Luca, G, Scaramellini, N, Di Stefano, V, Leoni, S, Seghezzi, S, Di Mauro, A, Maira, D, Mancarella, M, Lucchi, T, Rossi, P, Clerici, M, Bonini, G, Conti, F, Prolo, S, Fabrizi, M, Martelengo, M, Vigani, G, Nicolini, P, Di Sabatino, A, Miceli, E, Lenti, M, Pisati, M, Pitotti, L, Padula, D, Antoci, V, Cambie, G, Pontremoli, R, Beccati, V, Nobili, G, Leoncini, G, Alberto, J, Cattaneo, F, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Guagnano, M, Rossi, I, Valeriani, E, D'Ardes, D, Esposito, L, Sestili, S, Angelucci, E, Mancuso, G, Calipari, D, Bartone, M, Delitala, G, Berria, M, Delitala, A, Muscaritoli, M, Molfino, A, Petrillo, E, Giorgi, A, Gracin, C, Imbimbo, G, Zuccala, G, D'Aurizio, G, Romanelli, G, Volpini, A, Lucente, D, Manzoni, F, Pirozzi, A, Zucchelli, A, Picardi, A, Gentilucci, U, Gallo, P, Dell'Unto, C, Bellelli, G, Corsi, M, Antonucci, C, Sidoli, C, Principato, G, Bonfanti, A, Szabo, H, Mazzola, P, Piazzoli, A, Arturi, F, Succurro, E, Tassone, B, Giofre, F, Serra, M, Bleve, M, Brucato, A, De Falco, T, Negro, E, Brenna, M, Trotta, L, Squintani, G, Randi, M, Fabris, F, Bertozzi, I, Bogoni, G, Rabuini, M, Prandini, T, Ratti, F, Zurlo, C, Cerruti, L, Cosi, E, Manfredini, R, Boari, B, De Giorgi, A, Tiseo, R, Viglione, G, Savrie, C, Paolisso, G, Rizzo, M, Catalano, C, Di Meo, I, Borghi, C, Strocchi, E, Ianniello, E, Soldati, M, Schiavone, S, Bragagni, A, Leoni, F, De Sando, V, Scarduelli, S, Cammarosano, M, Pareo, I, Sabba, C, Vella, F, Suppressa, P, De Vincenzo, G, Comitangelo, A, Amoruso, E, Custodero, C, Re, G, Schilardi, A, Loparco, F, Fenoglio, L, Falcetta, A, Giraudo, A, D'Aniano, S, Fracanzani, A, Tiraboschi, S, Cespiati, A, Oberti, G, Sigon, G, Cinque, F, Peyvandi, F, Rossio, R, Colombo, G, Agosti, P, Pagliaro, E, Semproni, E, Ciro, C, Monzani, V, Savojardo, V, Ceriani, G, Folli, C, Salerno, F, Pallini, G, Montecucco, F, Ottonello, L, Caserza, L, Vischi, G, Kassem, S, Liberale, L, Liberato, N, Tognin, T, Purrello, F, Di Pino, A, Piro, S, Rozzini, R, Falanga, L, Pisciotta, M, Bellucci, F, Buffelli, S, Ferrandina, C, Mazzeo, F, Spazzini, E, Cono, G, Cesaroni, G, Montrucchio, G, Peasso, P, Favale, E, Poletto, C, Margaria, C, Sanino, M, Perri, L, Guasti, L, Rotunno, F, Castiglioni, L, Maresca, A, Squizzato, A, Campiotti, L, Grossi, A, Diprizio, R, Dentali, F, Bertolotti, M, Mussi, C, Lancellotti, G, Libbra, M, Galassi, M, Grassi, Y, Greco, A, Bigi, E, Pellegrini, E, Orlandi, L, Dondi, G, Carulli, L, Sciacqua, A, Perticone, M, Battaglia, R, Maio, R, Scozzafava, A, Condoleo, V, Falbo, T, Colangelo, L, Filice, M, Clausi, E, Stanghellini, V, Ruggeri, E, Del Vecchio, S, Benzoni, I, Salvi, A, Leonardi, R, Damiani, G, Moroncini, G, Capeci, W, Mattioli, M, Martino, G, Biondi, L, Pettinari, P, Ormas, M, Filippini, E, Benfaremo, D, Romiti, R, Ghio, R, Dal Col, A, Minisola, S, Cilli, M, Labbadia, G, Afeltra, A, Marigliano, B, Pipita, M, Castellino, P, Zanoli, L, Gennaro, A, Gaudio, A, Pignataro, S, Mete, F, Gino, M, Moreo, G, Pina, G, Ballestrero, A, Ferrando, F, Gonella, R, Cerminara, D, Setti, P, Traversa, C, Scarsi, C, Graziella, B, Baldassarre, S, Fragapani, S, Gruden, G, Berti, F, Famularo, G, Tarsitani, P, Castello, R, Pasino, M, Gian Paolo Ceda, M, Morganti, S, Artoni, A, Grossi, M, Del Giacco, S, Firinu, D, Costanzo, G, Argiolas, G, Paoletti, G, Losa, F, Montalto, G, Licata, A, Montalto, F, Rizzo, A, Corica, F, Basile, G, Catalano, A, Bellone, F, Principato, C, Malatino, L, Stancanelli, B, Terranova, V, Di Marca, S, Di Quattro, R, La Malfa, L, Caruso, R, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Ticinesi, A, Nouvenne, A, Minuz, P, Fondrieschi, L, Imperiale, G, Morellini, S, Pirisi, M, Fra, G, Sola, D, Bellan, M, Quadri, R, Larovere, E, Novelli, M, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Napoli, F, Aiello, I, Salvatore, T, Monaco, L, Ricozzi, C, Pilotto, A, Indiano, I, Gandolfo, F, Pasini, F, Capecchi, P, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Bernardi, M, Li Bassi, S, Santi, L, Zaccherini, G, Durante, V, Tirotta, D, Eusebi, G, Cattaneo, M, Amoruso, M, Fracasso, P, Fasolino, C, Tresoldi, M, Bozzolo, E, Damanti, S, Porta, M, Crisafulli E., Sartori G., Vianello A., Busti F., Nobili A., Mannucci P. M., Girelli D., Sesti G., Pietrangelo A., Perticone F., Violi F., Corrao S., Marengoni A., Tettamanti M., Pasina L., Franchi C., Novella A., Miglio G., Galbussera A. A., Ardoino I., Prisco D., Silvestri E., Emmi G., Bettiol A., Mattioli I., Biolo G., Zanetti M., Bartelloni G., Zaccari M., Chiuch M., Vanoli M., Grignani G., Pulixi E. A., Pirro M., Lupattelli G., Bianconi V., Alcidi R., Giotta A., Mannarino M. R., Marchi G., Barbagallo M., Dominguez L., Beneduce V., Cacioppo F., Natoli G., Mularo S., Raspanti M., Argano C., Cavallaro F., Zoli M., Matacena M. L., Orio G., Magnolfi E., Serafini G., Simili A., Brunori M., Lazzari I., Cappellini M. D., Fabio G., De Amicis M. M., De Luca G., Scaramellini N., Di Stefano V., Leoni S., Seghezzi S., Di Mauro A. D., Maira D., Mancarella M., Lucchi T., Rossi P. D., Clerici M., Bonini G., Conti F., Prolo S., Fabrizi M., Martelengo M., Vigani G., Nicolini P., Di Sabatino A., Miceli E., Lenti M. V., Pisati M., Pitotti L., Padula D., Antoci V., Cambie G., Pontremoli R., Beccati V., Nobili G., Leoncini G., Alberto J., Cattaneo F., Anastasio L., Sofia L., Carbone M., Cipollone F., Guagnano M. T., Rossi I., Valeriani E., D'Ardes D., Esposito L., Sestili S., Angelucci E., Mancuso G., Calipari D., Bartone M., Delitala G., Berria M., Delitala A., Muscaritoli M., Molfino A., Petrillo E., Giorgi A., Gracin C., Imbimbo G., Zuccala G., D'Aurizio G., Romanelli G., Volpini A., Lucente D., Manzoni F., Pirozzi A., Zucchelli A., Picardi A., Gentilucci U. V., Gallo P., Dell'Unto C., Bellelli G., Corsi M., Antonucci C., Sidoli C., Principato G., Bonfanti A., Szabo H., Mazzola P., Piazzoli A., Arturi F., Succurro E., Tassone B., Giofre F., Serra M. G., Bleve M. A., Brucato A., De Falco T., Negro E., Brenna M., Trotta L., Squintani G. L., Randi M. L., Fabris F., Bertozzi I., Bogoni G., Rabuini M. V., Prandini T., Ratti F., Zurlo C., Cerruti L., Cosi E., Manfredini R., Boari B., De Giorgi A., Tiseo R., Viglione G. M., Savrie C., Paolisso G., Rizzo M. R., Catalano C., Di Meo I., Borghi C., Strocchi E., Ianniello E., Soldati M., Schiavone S., Bragagni A., Leoni F. G., De Sando V., Scarduelli S., Cammarosano M., Pareo I., Sabba C., Vella F. S., Suppressa P., De Vincenzo G. M., Comitangelo A., Amoruso E., Custodero C., Re G., Schilardi A., Loparco F., Fenoglio L., Falcetta A., Giraudo A. V., D'Aniano S., Fracanzani A. L., Tiraboschi S., Cespiati A., Oberti G., Sigon G., Cinque F., Peyvandi F., Rossio R., Colombo G., Agosti P., Pagliaro E., Semproni E., Ciro C., Monzani V., Savojardo V., Ceriani G., Folli C., Salerno F., Pallini G., Montecucco F., Ottonello L., Caserza L., Vischi G., Kassem S., Liberale L., Liberato N. L., Tognin T., Purrello F., Di Pino A., Piro S., Rozzini R., Falanga L., Pisciotta M. S., Bellucci F. B., Buffelli S., Ferrandina C., Mazzeo F., Spazzini E., Cono G., Cesaroni G., Montrucchio G., Peasso P., Favale E., Poletto C., Margaria C., Sanino M., Perri L., Guasti L., Rotunno F., Castiglioni L., Maresca A., Squizzato A., Campiotti L., Grossi A., Diprizio R. D., Dentali F., Bertolotti M., Mussi C., Lancellotti G., Libbra M. V., Galassi M., Grassi Y., Greco A., Bigi E., Pellegrini E., Orlandi L., Dondi G., Carulli L., Sciacqua A., Perticone M., Battaglia R., Maio R., Scozzafava A., Condoleo V., Falbo T., Colangelo L., Filice M., Clausi E., Stanghellini V., Ruggeri E., Del Vecchio S., Benzoni I., Salvi A., Leonardi R., Damiani G., Moroncini G., Capeci W., Mattioli M., Martino G. P., Biondi L., Pettinari P., Ormas M., Filippini E., Benfaremo D., Romiti R., Ghio R., Dal Col A., Minisola S., Cilli M., Labbadia G., Afeltra A., Marigliano B., Pipita M. E., Castellino P., Zanoli L., Gennaro A., Gaudio A., Pignataro S., Mete F., Gino M., Moreo G., Pina G., Ballestrero A., Ferrando F., Gonella R., Cerminara D., Setti P., Traversa C., Scarsi C., Graziella B., Baldassarre S., Fragapani S., Gruden G., Berti F., Famularo G., Tarsitani P., Castello R., Pasino M., Gian Paolo Ceda M. G. M., Morganti S., Artoni A., Grossi M., Del Giacco S., Firinu D., Costanzo G., Argiolas G., Paoletti G., Losa F., Montalto G., Licata A., Montalto F. A., Rizzo A., Corica F., Basile G., Catalano A., Bellone F., Principato C., Malatino L., Stancanelli B., Terranova V., Di Marca S., Di Quattro R., La Malfa L., Caruso R., Mecocci P., Ruggiero C., Boccardi V., Meschi T., Ticinesi A., Nouvenne A., Minuz P., Fondrieschi L., Imperiale G. N., Morellini S., Pirisi M., Fra G. P., Sola D., Bellan M., Quadri R., Larovere E., Novelli M., Simeone E., Scurti R., Tolloso F., Tarquini R., Valoriani A., Dolenti S., Vannini G., Volpi R., Bocchi P., Vignali A., Harari S., Lonati C., Napoli F., Aiello I., Salvatore T., Monaco L., Ricozzi C., Pilotto A., Indiano I., Gandolfo F., Pasini F. L., Capecchi P. L., Nuti R., Valenti R., Ruvio M., Cappelli S., Palazzuoli A., Bernardi M., Li Bassi S., Santi L., Zaccherini G., Durante V., Tirotta D., Eusebi G., Cattaneo M., Amoruso M. V., Fracasso P., Fasolino C., Tresoldi M., Bozzolo E., Damanti S., Porta M., Crisafulli, E, Sartori, G, Vianello, A, Busti, F, Nobili, A, Mannucci, P, Girelli, D, Sesti, G, Pietrangelo, A, Perticone, F, Violi, F, Corrao, S, Marengoni, A, Tettamanti, M, Pasina, L, Franchi, C, Novella, A, Miglio, G, Galbussera, A, Ardoino, I, Prisco, D, Silvestri, E, Emmi, G, Bettiol, A, Mattioli, I, Biolo, G, Zanetti, M, Bartelloni, G, Zaccari, M, Chiuch, M, Vanoli, M, Grignani, G, Pulixi, E, Pirro, M, Lupattelli, G, Bianconi, V, Alcidi, R, Giotta, A, Mannarino, M, Marchi, G, Barbagallo, M, Dominguez, L, Beneduce, V, Cacioppo, F, Natoli, G, Mularo, S, Raspanti, M, Argano, C, Cavallaro, F, Zoli, M, Matacena, M, Orio, G, Magnolfi, E, Serafini, G, Simili, A, Brunori, M, Lazzari, I, Cappellini, M, Fabio, G, De Amicis, M, De Luca, G, Scaramellini, N, Di Stefano, V, Leoni, S, Seghezzi, S, Di Mauro, A, Maira, D, Mancarella, M, Lucchi, T, Rossi, P, Clerici, M, Bonini, G, Conti, F, Prolo, S, Fabrizi, M, Martelengo, M, Vigani, G, Nicolini, P, Di Sabatino, A, Miceli, E, Lenti, M, Pisati, M, Pitotti, L, Padula, D, Antoci, V, Cambie, G, Pontremoli, R, Beccati, V, Nobili, G, Leoncini, G, Alberto, J, Cattaneo, F, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Guagnano, M, Rossi, I, Valeriani, E, D'Ardes, D, Esposito, L, Sestili, S, Angelucci, E, Mancuso, G, Calipari, D, Bartone, M, Delitala, G, Berria, M, Delitala, A, Muscaritoli, M, Molfino, A, Petrillo, E, Giorgi, A, Gracin, C, Imbimbo, G, Zuccala, G, D'Aurizio, G, Romanelli, G, Volpini, A, Lucente, D, Manzoni, F, Pirozzi, A, Zucchelli, A, Picardi, A, Gentilucci, U, Gallo, P, Dell'Unto, C, Bellelli, G, Corsi, M, Antonucci, C, Sidoli, C, Principato, G, Bonfanti, A, Szabo, H, Mazzola, P, Piazzoli, A, Arturi, F, Succurro, E, Tassone, B, Giofre, F, Serra, M, Bleve, M, Brucato, A, De Falco, T, Negro, E, Brenna, M, Trotta, L, Squintani, G, Randi, M, Fabris, F, Bertozzi, I, Bogoni, G, Rabuini, M, Prandini, T, Ratti, F, Zurlo, C, Cerruti, L, Cosi, E, Manfredini, R, Boari, B, De Giorgi, A, Tiseo, R, Viglione, G, Savrie, C, Paolisso, G, Rizzo, M, Catalano, C, Di Meo, I, Borghi, C, Strocchi, E, Ianniello, E, Soldati, M, Schiavone, S, Bragagni, A, Leoni, F, De Sando, V, Scarduelli, S, Cammarosano, M, Pareo, I, Sabba, C, Vella, F, Suppressa, P, De Vincenzo, G, Comitangelo, A, Amoruso, E, Custodero, C, Re, G, Schilardi, A, Loparco, F, Fenoglio, L, Falcetta, A, Giraudo, A, D'Aniano, S, Fracanzani, A, Tiraboschi, S, Cespiati, A, Oberti, G, Sigon, G, Cinque, F, Peyvandi, F, Rossio, R, Colombo, G, Agosti, P, Pagliaro, E, Semproni, E, Ciro, C, Monzani, V, Savojardo, V, Ceriani, G, Folli, C, Salerno, F, Pallini, G, Montecucco, F, Ottonello, L, Caserza, L, Vischi, G, Kassem, S, Liberale, L, Liberato, N, Tognin, T, Purrello, F, Di Pino, A, Piro, S, Rozzini, R, Falanga, L, Pisciotta, M, Bellucci, F, Buffelli, S, Ferrandina, C, Mazzeo, F, Spazzini, E, Cono, G, Cesaroni, G, Montrucchio, G, Peasso, P, Favale, E, Poletto, C, Margaria, C, Sanino, M, Perri, L, Guasti, L, Rotunno, F, Castiglioni, L, Maresca, A, Squizzato, A, Campiotti, L, Grossi, A, Diprizio, R, Dentali, F, Bertolotti, M, Mussi, C, Lancellotti, G, Libbra, M, Galassi, M, Grassi, Y, Greco, A, Bigi, E, Pellegrini, E, Orlandi, L, Dondi, G, Carulli, L, Sciacqua, A, Perticone, M, Battaglia, R, Maio, R, Scozzafava, A, Condoleo, V, Falbo, T, Colangelo, L, Filice, M, Clausi, E, Stanghellini, V, Ruggeri, E, Del Vecchio, S, Benzoni, I, Salvi, A, Leonardi, R, Damiani, G, Moroncini, G, Capeci, W, Mattioli, M, Martino, G, Biondi, L, Pettinari, P, Ormas, M, Filippini, E, Benfaremo, D, Romiti, R, Ghio, R, Dal Col, A, Minisola, S, Cilli, M, Labbadia, G, Afeltra, A, Marigliano, B, Pipita, M, Castellino, P, Zanoli, L, Gennaro, A, Gaudio, A, Pignataro, S, Mete, F, Gino, M, Moreo, G, Pina, G, Ballestrero, A, Ferrando, F, Gonella, R, Cerminara, D, Setti, P, Traversa, C, Scarsi, C, Graziella, B, Baldassarre, S, Fragapani, S, Gruden, G, Berti, F, Famularo, G, Tarsitani, P, Castello, R, Pasino, M, Gian Paolo Ceda, M, Morganti, S, Artoni, A, Grossi, M, Del Giacco, S, Firinu, D, Costanzo, G, Argiolas, G, Paoletti, G, Losa, F, Montalto, G, Licata, A, Montalto, F, Rizzo, A, Corica, F, Basile, G, Catalano, A, Bellone, F, Principato, C, Malatino, L, Stancanelli, B, Terranova, V, Di Marca, S, Di Quattro, R, La Malfa, L, Caruso, R, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Ticinesi, A, Nouvenne, A, Minuz, P, Fondrieschi, L, Imperiale, G, Morellini, S, Pirisi, M, Fra, G, Sola, D, Bellan, M, Quadri, R, Larovere, E, Novelli, M, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Napoli, F, Aiello, I, Salvatore, T, Monaco, L, Ricozzi, C, Pilotto, A, Indiano, I, Gandolfo, F, Pasini, F, Capecchi, P, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Bernardi, M, Li Bassi, S, Santi, L, Zaccherini, G, Durante, V, Tirotta, D, Eusebi, G, Cattaneo, M, Amoruso, M, Fracasso, P, Fasolino, C, Tresoldi, M, Bozzolo, E, Damanti, S, Porta, M, Crisafulli E., Sartori G., Vianello A., Busti F., Nobili A., Mannucci P. M., Girelli D., Sesti G., Pietrangelo A., Perticone F., Violi F., Corrao S., Marengoni A., Tettamanti M., Pasina L., Franchi C., Novella A., Miglio G., Galbussera A. A., Ardoino I., Prisco D., Silvestri E., Emmi G., Bettiol A., Mattioli I., Biolo G., Zanetti M., Bartelloni G., Zaccari M., Chiuch M., Vanoli M., Grignani G., Pulixi E. A., Pirro M., Lupattelli G., Bianconi V., Alcidi R., Giotta A., Mannarino M. R., Marchi G., Barbagallo M., Dominguez L., Beneduce V., Cacioppo F., Natoli G., Mularo S., Raspanti M., Argano C., Cavallaro F., Zoli M., Matacena M. L., Orio G., Magnolfi E., Serafini G., Simili A., Brunori M., Lazzari I., Cappellini M. D., Fabio G., De Amicis M. M., De Luca G., Scaramellini N., Di Stefano V., Leoni S., Seghezzi S., Di Mauro A. D., Maira D., Mancarella M., Lucchi T., Rossi P. D., Clerici M., Bonini G., Conti F., Prolo S., Fabrizi M., Martelengo M., Vigani G., Nicolini P., Di Sabatino A., Miceli E., Lenti M. V., Pisati M., Pitotti L., Padula D., Antoci V., Cambie G., Pontremoli R., Beccati V., Nobili G., Leoncini G., Alberto J., Cattaneo F., Anastasio L., Sofia L., Carbone M., Cipollone F., Guagnano M. T., Rossi I., Valeriani E., D'Ardes D., Esposito L., Sestili S., Angelucci E., Mancuso G., Calipari D., Bartone M., Delitala G., Berria M., Delitala A., Muscaritoli M., Molfino A., Petrillo E., Giorgi A., Gracin C., Imbimbo G., Zuccala G., D'Aurizio G., Romanelli G., Volpini A., Lucente D., Manzoni F., Pirozzi A., Zucchelli A., Picardi A., Gentilucci U. V., Gallo P., Dell'Unto C., Bellelli G., Corsi M., Antonucci C., Sidoli C., Principato G., Bonfanti A., Szabo H., Mazzola P., Piazzoli A., Arturi F., Succurro E., Tassone B., Giofre F., Serra M. G., Bleve M. A., Brucato A., De Falco T., Negro E., Brenna M., Trotta L., Squintani G. L., Randi M. L., Fabris F., Bertozzi I., Bogoni G., Rabuini M. V., Prandini T., Ratti F., Zurlo C., Cerruti L., Cosi E., Manfredini R., Boari B., De Giorgi A., Tiseo R., Viglione G. M., Savrie C., Paolisso G., Rizzo M. R., Catalano C., Di Meo I., Borghi C., Strocchi E., Ianniello E., Soldati M., Schiavone S., Bragagni A., Leoni F. G., De Sando V., Scarduelli S., Cammarosano M., Pareo I., Sabba C., Vella F. S., Suppressa P., De Vincenzo G. M., Comitangelo A., Amoruso E., Custodero C., Re G., Schilardi A., Loparco F., Fenoglio L., Falcetta A., Giraudo A. V., D'Aniano S., Fracanzani A. L., Tiraboschi S., Cespiati A., Oberti G., Sigon G., Cinque F., Peyvandi F., Rossio R., Colombo G., Agosti P., Pagliaro E., Semproni E., Ciro C., Monzani V., Savojardo V., Ceriani G., Folli C., Salerno F., Pallini G., Montecucco F., Ottonello L., Caserza L., Vischi G., Kassem S., Liberale L., Liberato N. L., Tognin T., Purrello F., Di Pino A., Piro S., Rozzini R., Falanga L., Pisciotta M. S., Bellucci F. B., Buffelli S., Ferrandina C., Mazzeo F., Spazzini E., Cono G., Cesaroni G., Montrucchio G., Peasso P., Favale E., Poletto C., Margaria C., Sanino M., Perri L., Guasti L., Rotunno F., Castiglioni L., Maresca A., Squizzato A., Campiotti L., Grossi A., Diprizio R. D., Dentali F., Bertolotti M., Mussi C., Lancellotti G., Libbra M. V., Galassi M., Grassi Y., Greco A., Bigi E., Pellegrini E., Orlandi L., Dondi G., Carulli L., Sciacqua A., Perticone M., Battaglia R., Maio R., Scozzafava A., Condoleo V., Falbo T., Colangelo L., Filice M., Clausi E., Stanghellini V., Ruggeri E., Del Vecchio S., Benzoni I., Salvi A., Leonardi R., Damiani G., Moroncini G., Capeci W., Mattioli M., Martino G. P., Biondi L., Pettinari P., Ormas M., Filippini E., Benfaremo D., Romiti R., Ghio R., Dal Col A., Minisola S., Cilli M., Labbadia G., Afeltra A., Marigliano B., Pipita M. E., Castellino P., Zanoli L., Gennaro A., Gaudio A., Pignataro S., Mete F., Gino M., Moreo G., Pina G., Ballestrero A., Ferrando F., Gonella R., Cerminara D., Setti P., Traversa C., Scarsi C., Graziella B., Baldassarre S., Fragapani S., Gruden G., Berti F., Famularo G., Tarsitani P., Castello R., Pasino M., Gian Paolo Ceda M. G. M., Morganti S., Artoni A., Grossi M., Del Giacco S., Firinu D., Costanzo G., Argiolas G., Paoletti G., Losa F., Montalto G., Licata A., Montalto F. A., Rizzo A., Corica F., Basile G., Catalano A., Bellone F., Principato C., Malatino L., Stancanelli B., Terranova V., Di Marca S., Di Quattro R., La Malfa L., Caruso R., Mecocci P., Ruggiero C., Boccardi V., Meschi T., Ticinesi A., Nouvenne A., Minuz P., Fondrieschi L., Imperiale G. N., Morellini S., Pirisi M., Fra G. P., Sola D., Bellan M., Quadri R., Larovere E., Novelli M., Simeone E., Scurti R., Tolloso F., Tarquini R., Valoriani A., Dolenti S., Vannini G., Volpi R., Bocchi P., Vignali A., Harari S., Lonati C., Napoli F., Aiello I., Salvatore T., Monaco L., Ricozzi C., Pilotto A., Indiano I., Gandolfo F., Pasini F. L., Capecchi P. L., Nuti R., Valenti R., Ruvio M., Cappelli S., Palazzuoli A., Bernardi M., Li Bassi S., Santi L., Zaccherini G., Durante V., Tirotta D., Eusebi G., Cattaneo M., Amoruso M. V., Fracasso P., Fasolino C., Tresoldi M., Bozzolo E., Damanti S., and Porta M.

Abstract

Background and objective: Chronic obstructive pulmonary disease (COPD) and heart failure (HF) mutually increase the risk of being present in the same patient, especially if older. Whether or not this coexistence may be associated with a worse prognosis is debated. Therefore, employing data derived from the REPOSI register, we evaluated the clinical features and outcomes in a population of elderly patients admitted to internal medicine wards and having COPD, HF or COPD + HF. Methods: We measured socio-demographic and anthropometric characteristics, severity and prevalence of comorbidities, clinical and laboratory features during hospitalization, mood disorders, functional independence, drug prescriptions and discharge destination. The primary study outcome was the risk of death. Results: We considered 2,343 elderly hospitalized patients (median age 81 years), of whom 1,154 (49%) had COPD, 813 (35%) HF, and 376 (16%) COPD + HF. Patients with COPD + HF had different characteristics than those with COPD or HF, such as a higher prevalence of previous hospitalizations, comorbidities (especially chronic kidney disease), higher respiratory rate at admission and number of prescribed drugs. Patients with COPD + HF (hazard ratio HR 1.74, 95% confidence intervals CI 1.16–2.61) and patients with dementia (HR 1.75, 95% CI 1.06–2.90) had a higher risk of death at one year. The Kaplan–Meier curves showed a higher mortality risk in the group of patients with COPD + HF for all causes (p = 0.010), respiratory causes (p = 0.006), cardiovascular causes (p = 0.046) and respiratory plus cardiovascular causes (p = 0.009). Conclusion: In this real-life cohort of hospitalized elderly patients, the coexistence of COPD and HF significantly worsened prognosis at one year. This finding may help to better define the care needs of this population.

Published
2023

30. Correction to: Prescription appropriateness of anti-diabetes drugs in elderly patients hospitalized in a clinical setting: evidence from the REPOSI Register (Internal and Emergency Medicine, (2023), 18, 4, (1049-1063), 10.1007/s11739-023-03254-3)

Author

Succurro E., Succurro, E, Novella, A, Nobili, A, Giofre, F, Arturi, F, Sciacqua, A, Andreozzi, F, Pietrangelo, A, Sesti, G, Perticone, F, Violi, F, Corrao, S, Marengoni, A, Tettamanti, M, Pasina, L, Franchi, C, Miglio, G, Ardoino, I, Cantiero, S, Prisco, D, Silvestri, E, Emmi, G, Bettiol, A, Mattioli, I, Mazzetti, M, Biolo, G, Zanetti, M, Bartelloni, G, Zaccari, M, Chiuch, M, Martini, I, Pirro, M, Lupattelli, G, Bianconi, V, Alcidi, R, Giotta, A, Mannarino, M, Girelli, D, Busti, F, Marchi, G, Barbagallo, M, Dominguez, L, Beneduce, V, Cacioppo, F, Natoli, G, Mularo, S, Raspanti, M, Argano, C, Cavallaro, F, Zoli, M, Orio, G, Magnolfi, E, Serafini, G, Brunori, M, Lazzari, I, Simili, A, Fabio, G, De Amicis, M, Luca, G, Scaramellini, N, Stefano, V, Leoni, S, Seghezzi, S, Di Mauro, A, Maira, D, Mancarella, M, Lucchi, T, Clerici, M, Bonini, G, Conti, F, Prolo, S, Fabrizi, M, Martelengo, M, Vigani, G, Nicolini, P, Sabatino, A, Miceli, E, Pisati, M, Pitotti, L, Antoci, V, Cambie, G, Pontremoli, R, Beccati, V, Nobili, G, Leoncini, G, Alberto, J, Cattaneo, F, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Rossi, I, Valeriani, E, D'Ardes, D, Cipollone, A, Esposito, L, Sestili, S, Angelucci, E, Mancuso, G, Calipari, D, Bartone, M, Manetti, R, Sircana, M, Berria, M, Delitala, A, Muscaritoli, M, Molfino, A, Petrillo, E, Giorgi, A, Gracin, C, Imbimbo, G, Romanelli, G, Volpini, A, Lucente, D, Manzoni, F, Pirozzi, A, Zucchelli, A, Geneletti, T, Picardi, A, Bellelli, G, Corsi, M, Antonucci, C, Sidoli, C, Principato, G, Bonfanti, A, Szabo, H, Mazzola, P, Piazzoli, A, Tassone, B, De Falco, A, Negro, E, Brenna, M, Trotta, L, Fabris, F, Bertozzi, I, Bogoni, G, Prandini, T, Ratti, F, Zurlo, C, Cerruti, L, Cosi, E, Reni, E, Manfredini, R, Boari, B, Tiseo, R, Savrie, C, Fabbian, F, Paolisso, G, Catalano, C, Meo, I, Sabba, C, Suppressa, P, De Vincenzo, G, Comitangelo, A, Amoruso, E, Custodero, C, Re, G, Barnaba, I, Schilardi, A, Fenoglio, L, Falcetta, A, D'Aniano, S, Tiraboschi, S, Cespiati, A, Oberti, G, Sigon, G, Cinque, F, Colavolpe, L, Curra, J, Alletto, F, Benzoni, G, Peyvandi, F, Rossio, R, Colombo, G, Agosti, P, Pagliaro, E, Semproni, E, Canetta, C, Monzani, V, Savojardo, V, Ceriani, G, Folli, C, Tognin, T, Purrello, F, Pino, A, Piro, S, Rozzini, R, Falanga, L, Boffelli, S, Ferrandina, C, Mazzeo, F, Spazzini, E, Cono, G, Cesaroni, G, Perri, L, Guasti, L, Rotunno, F, Castiglioni, L, Maresca, A, Squizzato, A, Campiotti, L, Grossi, A, Dentali, F, Behnke, V, Perticone, M, Maio, R, Scozzafava, A, Condoleo, V, Clausi, E, Armentaro, G, Panza, A, Stanghellini, V, Ruggeri, E, Vecchio, S, Benzoni, I, Minisola, S, Colangelo, L, Cilli, M, Labbadia, G, Pepe, J, Castellino, P, Zanoli, L, Gaudio, A, Xourafa, A, Spichetti, C, Torre, S, Gennaro, A, Ballestrero, A, Ferrando, F, Gonella, R, Cerminara, D, Setti, P, Traversa, C, Scarsi, C, Famularo, G, Tarsitani, P, Morretti, T, Aglitti, A, Giacco, S, Firinu, D, Costanzo, G, Chessa, S, Montalto, G, Licata, A, Rizzo, A, Corica, F, Basile, G, Catalano, A, Bellone, F, Principato, C, Cocuzza, A, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Ticinesi, A, Nouvenne, A, Pirisi, M, Sola, D, Bellan, M, Quadri, R, Larovere, E, Novelli, M, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Napoli, F, Aiello, I, Salvatore, T, Monaco, L, Ricozzi, C, Coviello, F, Catalini, C, Pilotto, A, Indiano, I, Gandolfo, F, Gonella, D, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Durante, V, Tirotta, D, Eusebi, G, Tresoldi, M, Bozzolo, E, Damanti, S, Porta, M, Gino, M, Pari, B, Pace, E, Succurro E., Novella A., Nobili A., Giofre F., Arturi F., Sciacqua A., Andreozzi F., Pietrangelo A., Sesti G., Perticone F., Violi F., Corrao S., Marengoni A., Tettamanti M., Pasina L., Franchi C., Miglio G., Ardoino I., Cantiero S., Prisco D., Silvestri E., Emmi G., Bettiol A., Mattioli I., Mazzetti M., Biolo G., Zanetti M., Bartelloni G., Zaccari M., Chiuch M., Martini I., Pirro M., Lupattelli G., Bianconi V., Alcidi R., Giotta A., Mannarino M. R., Girelli D., Busti F., Marchi G., Barbagallo M., Dominguez L., Beneduce V., Cacioppo F., Natoli G., Mularo S., Raspanti M., Argano C., Cavallaro F., Zoli M., Orio G., Magnolfi E., Serafini G., Brunori M., Lazzari I., Simili A., Fabio G., De Amicis M. M., Luca G., Scaramellini N., Stefano V., Leoni S., Seghezzi S., Di Mauro A. D., Maira D., Mancarella M., Lucchi T., Clerici M., Bonini G., Conti F., Prolo S., Fabrizi M., Martelengo M., Vigani G., Nicolini P., Sabatino A., Miceli E., Pisati M., Pitotti L., Antoci V., Cambie G., Pontremoli R., Beccati V., Nobili G., Leoncini G., Alberto J., Cattaneo F., Anastasio L., Sofia L., Carbone M., Cipollone F., Rossi I., Valeriani E., D'Ardes D., Cipollone A., Esposito L., Sestili S., Angelucci E., Mancuso G., Calipari D., Bartone M., Manetti R., Sircana M., Berria M., Delitala A., Muscaritoli M., Molfino A., Petrillo E., Giorgi A., Gracin C., Imbimbo G., Romanelli G., Volpini A., Lucente D., Manzoni F., Pirozzi A., Zucchelli A., Geneletti T., Picardi A., Bellelli G., Corsi M., Antonucci C., Sidoli C., Principato G., Bonfanti A., Szabo H., Mazzola P., Piazzoli A., Tassone B., De Falco A. B. T., Negro E., Brenna M., Trotta L., Fabris F., Bertozzi I., Bogoni G., Prandini T., Ratti F., Zurlo C., Cerruti L., Cosi E., Reni E., Manfredini R., Boari B., Tiseo R., Savrie C., Fabbian F., Paolisso G., Catalano C., Meo I., Sabba C., Suppressa P., De Vincenzo G. M., Comitangelo A., Amoruso E., Custodero C., Re G., Barnaba I., Schilardi A., Fenoglio L., Falcetta A., D'Aniano S., Tiraboschi S., Cespiati A., Oberti G., Sigon G., Cinque F., Colavolpe L., Curra J., Alletto F., Benzoni G., Peyvandi F., Rossio R., Colombo G., Agosti P., Pagliaro E., Semproni E., Canetta C., Monzani V., Savojardo V., Ceriani G., Folli C., Tognin T., Purrello F., Pino A., Piro S., Rozzini R., Falanga L., Boffelli S., Ferrandina C., Mazzeo F., Spazzini E., Cono G., Cesaroni G., Perri L., Guasti L., Rotunno F., Castiglioni L., Maresca A., Squizzato A., Campiotti L., Grossi A., Dentali F., Behnke V., Perticone M., Maio R., Scozzafava A., Condoleo V., Clausi E., Armentaro G., Panza A., Stanghellini V., Ruggeri E., Vecchio S., Benzoni I., Minisola S., Colangelo L., Cilli M., Labbadia G., Pepe J., Castellino P., Zanoli L., Gaudio A., Xourafa A., Spichetti C., Torre S., Gennaro A., Ballestrero A., Ferrando F., Gonella R., Cerminara D., Setti P., Traversa C., Scarsi C., Famularo G., Tarsitani P., Morretti T., Aglitti A., Giacco S., Firinu D., Costanzo G., Chessa S., Montalto G., Licata A., Rizzo A., Corica F., Basile G., Catalano A., Bellone F., Principato C., Cocuzza A., Mecocci P., Ruggiero C., Boccardi V., Meschi T., Ticinesi A., Nouvenne A., Pirisi M., Sola D., Bellan M., Quadri R., Larovere E., Novelli M., Simeone E., Scurti R., Tolloso F., Tarquini R., Valoriani A., Dolenti S., Vannini G., Volpi R., Bocchi P., Vignali A., Harari S., Lonati C., Napoli F., Aiello I., Salvatore T., Monaco L., Ricozzi C., Coviello F., Catalini C., Pilotto A., Indiano I., Gandolfo F., Gonella D., Nuti R., Valenti R., Ruvio M., Cappelli S., Palazzuoli A., Durante V., Tirotta D., Eusebi G., Tresoldi M., Bozzolo E., Damanti S., Porta M., Gino M., Pari B., Pace E., Succurro E., Succurro, E, Novella, A, Nobili, A, Giofre, F, Arturi, F, Sciacqua, A, Andreozzi, F, Pietrangelo, A, Sesti, G, Perticone, F, Violi, F, Corrao, S, Marengoni, A, Tettamanti, M, Pasina, L, Franchi, C, Miglio, G, Ardoino, I, Cantiero, S, Prisco, D, Silvestri, E, Emmi, G, Bettiol, A, Mattioli, I, Mazzetti, M, Biolo, G, Zanetti, M, Bartelloni, G, Zaccari, M, Chiuch, M, Martini, I, Pirro, M, Lupattelli, G, Bianconi, V, Alcidi, R, Giotta, A, Mannarino, M, Girelli, D, Busti, F, Marchi, G, Barbagallo, M, Dominguez, L, Beneduce, V, Cacioppo, F, Natoli, G, Mularo, S, Raspanti, M, Argano, C, Cavallaro, F, Zoli, M, Orio, G, Magnolfi, E, Serafini, G, Brunori, M, Lazzari, I, Simili, A, Fabio, G, De Amicis, M, Luca, G, Scaramellini, N, Stefano, V, Leoni, S, Seghezzi, S, Di Mauro, A, Maira, D, Mancarella, M, Lucchi, T, Clerici, M, Bonini, G, Conti, F, Prolo, S, Fabrizi, M, Martelengo, M, Vigani, G, Nicolini, P, Sabatino, A, Miceli, E, Pisati, M, Pitotti, L, Antoci, V, Cambie, G, Pontremoli, R, Beccati, V, Nobili, G, Leoncini, G, Alberto, J, Cattaneo, F, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Rossi, I, Valeriani, E, D'Ardes, D, Cipollone, A, Esposito, L, Sestili, S, Angelucci, E, Mancuso, G, Calipari, D, Bartone, M, Manetti, R, Sircana, M, Berria, M, Delitala, A, Muscaritoli, M, Molfino, A, Petrillo, E, Giorgi, A, Gracin, C, Imbimbo, G, Romanelli, G, Volpini, A, Lucente, D, Manzoni, F, Pirozzi, A, Zucchelli, A, Geneletti, T, Picardi, A, Bellelli, G, Corsi, M, Antonucci, C, Sidoli, C, Principato, G, Bonfanti, A, Szabo, H, Mazzola, P, Piazzoli, A, Tassone, B, De Falco, A, Negro, E, Brenna, M, Trotta, L, Fabris, F, Bertozzi, I, Bogoni, G, Prandini, T, Ratti, F, Zurlo, C, Cerruti, L, Cosi, E, Reni, E, Manfredini, R, Boari, B, Tiseo, R, Savrie, C, Fabbian, F, Paolisso, G, Catalano, C, Meo, I, Sabba, C, Suppressa, P, De Vincenzo, G, Comitangelo, A, Amoruso, E, Custodero, C, Re, G, Barnaba, I, Schilardi, A, Fenoglio, L, Falcetta, A, D'Aniano, S, Tiraboschi, S, Cespiati, A, Oberti, G, Sigon, G, Cinque, F, Colavolpe, L, Curra, J, Alletto, F, Benzoni, G, Peyvandi, F, Rossio, R, Colombo, G, Agosti, P, Pagliaro, E, Semproni, E, Canetta, C, Monzani, V, Savojardo, V, Ceriani, G, Folli, C, Tognin, T, Purrello, F, Pino, A, Piro, S, Rozzini, R, Falanga, L, Boffelli, S, Ferrandina, C, Mazzeo, F, Spazzini, E, Cono, G, Cesaroni, G, Perri, L, Guasti, L, Rotunno, F, Castiglioni, L, Maresca, A, Squizzato, A, Campiotti, L, Grossi, A, Dentali, F, Behnke, V, Perticone, M, Maio, R, Scozzafava, A, Condoleo, V, Clausi, E, Armentaro, G, Panza, A, Stanghellini, V, Ruggeri, E, Vecchio, S, Benzoni, I, Minisola, S, Colangelo, L, Cilli, M, Labbadia, G, Pepe, J, Castellino, P, Zanoli, L, Gaudio, A, Xourafa, A, Spichetti, C, Torre, S, Gennaro, A, Ballestrero, A, Ferrando, F, Gonella, R, Cerminara, D, Setti, P, Traversa, C, Scarsi, C, Famularo, G, Tarsitani, P, Morretti, T, Aglitti, A, Giacco, S, Firinu, D, Costanzo, G, Chessa, S, Montalto, G, Licata, A, Rizzo, A, Corica, F, Basile, G, Catalano, A, Bellone, F, Principato, C, Cocuzza, A, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Ticinesi, A, Nouvenne, A, Pirisi, M, Sola, D, Bellan, M, Quadri, R, Larovere, E, Novelli, M, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Napoli, F, Aiello, I, Salvatore, T, Monaco, L, Ricozzi, C, Coviello, F, Catalini, C, Pilotto, A, Indiano, I, Gandolfo, F, Gonella, D, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Durante, V, Tirotta, D, Eusebi, G, Tresoldi, M, Bozzolo, E, Damanti, S, Porta, M, Gino, M, Pari, B, Pace, E, Succurro E., Novella A., Nobili A., Giofre F., Arturi F., Sciacqua A., Andreozzi F., Pietrangelo A., Sesti G., Perticone F., Violi F., Corrao S., Marengoni A., Tettamanti M., Pasina L., Franchi C., Miglio G., Ardoino I., Cantiero S., Prisco D., Silvestri E., Emmi G., Bettiol A., Mattioli I., Mazzetti M., Biolo G., Zanetti M., Bartelloni G., Zaccari M., Chiuch M., Martini I., Pirro M., Lupattelli G., Bianconi V., Alcidi R., Giotta A., Mannarino M. R., Girelli D., Busti F., Marchi G., Barbagallo M., Dominguez L., Beneduce V., Cacioppo F., Natoli G., Mularo S., Raspanti M., Argano C., Cavallaro F., Zoli M., Orio G., Magnolfi E., Serafini G., Brunori M., Lazzari I., Simili A., Fabio G., De Amicis M. M., Luca G., Scaramellini N., Stefano V., Leoni S., Seghezzi S., Di Mauro A. D., Maira D., Mancarella M., Lucchi T., Clerici M., Bonini G., Conti F., Prolo S., Fabrizi M., Martelengo M., Vigani G., Nicolini P., Sabatino A., Miceli E., Pisati M., Pitotti L., Antoci V., Cambie G., Pontremoli R., Beccati V., Nobili G., Leoncini G., Alberto J., Cattaneo F., Anastasio L., Sofia L., Carbone M., Cipollone F., Rossi I., Valeriani E., D'Ardes D., Cipollone A., Esposito L., Sestili S., Angelucci E., Mancuso G., Calipari D., Bartone M., Manetti R., Sircana M., Berria M., Delitala A., Muscaritoli M., Molfino A., Petrillo E., Giorgi A., Gracin C., Imbimbo G., Romanelli G., Volpini A., Lucente D., Manzoni F., Pirozzi A., Zucchelli A., Geneletti T., Picardi A., Bellelli G., Corsi M., Antonucci C., Sidoli C., Principato G., Bonfanti A., Szabo H., Mazzola P., Piazzoli A., Tassone B., De Falco A. B. T., Negro E., Brenna M., Trotta L., Fabris F., Bertozzi I., Bogoni G., Prandini T., Ratti F., Zurlo C., Cerruti L., Cosi E., Reni E., Manfredini R., Boari B., Tiseo R., Savrie C., Fabbian F., Paolisso G., Catalano C., Meo I., Sabba C., Suppressa P., De Vincenzo G. M., Comitangelo A., Amoruso E., Custodero C., Re G., Barnaba I., Schilardi A., Fenoglio L., Falcetta A., D'Aniano S., Tiraboschi S., Cespiati A., Oberti G., Sigon G., Cinque F., Colavolpe L., Curra J., Alletto F., Benzoni G., Peyvandi F., Rossio R., Colombo G., Agosti P., Pagliaro E., Semproni E., Canetta C., Monzani V., Savojardo V., Ceriani G., Folli C., Tognin T., Purrello F., Pino A., Piro S., Rozzini R., Falanga L., Boffelli S., Ferrandina C., Mazzeo F., Spazzini E., Cono G., Cesaroni G., Perri L., Guasti L., Rotunno F., Castiglioni L., Maresca A., Squizzato A., Campiotti L., Grossi A., Dentali F., Behnke V., Perticone M., Maio R., Scozzafava A., Condoleo V., Clausi E., Armentaro G., Panza A., Stanghellini V., Ruggeri E., Vecchio S., Benzoni I., Minisola S., Colangelo L., Cilli M., Labbadia G., Pepe J., Castellino P., Zanoli L., Gaudio A., Xourafa A., Spichetti C., Torre S., Gennaro A., Ballestrero A., Ferrando F., Gonella R., Cerminara D., Setti P., Traversa C., Scarsi C., Famularo G., Tarsitani P., Morretti T., Aglitti A., Giacco S., Firinu D., Costanzo G., Chessa S., Montalto G., Licata A., Rizzo A., Corica F., Basile G., Catalano A., Bellone F., Principato C., Cocuzza A., Mecocci P., Ruggiero C., Boccardi V., Meschi T., Ticinesi A., Nouvenne A., Pirisi M., Sola D., Bellan M., Quadri R., Larovere E., Novelli M., Simeone E., Scurti R., Tolloso F., Tarquini R., Valoriani A., Dolenti S., Vannini G., Volpi R., Bocchi P., Vignali A., Harari S., Lonati C., Napoli F., Aiello I., Salvatore T., Monaco L., Ricozzi C., Coviello F., Catalini C., Pilotto A., Indiano I., Gandolfo F., Gonella D., Nuti R., Valenti R., Ruvio M., Cappelli S., Palazzuoli A., Durante V., Tirotta D., Eusebi G., Tresoldi M., Bozzolo E., Damanti S., Porta M., Gino M., Pari B., and Pace E.

Abstract

In this article the names of a few collaborators and some data in Table 5 were missing. It has been corrected. The original article has been corrected.

Published
2023

31. The Effect of a Liver Transplant Program on the Outcomes of Resectable Hepatocellular Carcinoma: A Nationwide Multicenter Analysis

Author

Serenari, M, Lenzi, J, Cucchetti, A, Cipriani, F, Donadon, M, Ardito, F, Fazio, F, Nicolini, D, Iaria, M, Famularo, S, Perri, P, Ansaloni, L, Zanello, M, Lai, Q, Conci, S, Molfino, S, Ferrari, C, Germani, P, Zago, M, Romano, M, Zimmitti, G, Antonucci, A, Fumagalli, L, Troci, A, Ferraro, V, Memeo, R, Crespi, M, Chiarelli, M, Ercolani, G, Hilal, M, Zanus, G, Pinotti, E, Tarchi, P, Griseri, G, Baiocchi, G, Ruzzenente, A, Rossi, M, Jovine, E, Maestri, M, Grazi, G, Romano, F, Dalla Valle, R, Ravaioli, M, Vivarelli, M, Ferrero, A, Giuliante, F, Torzilli, G, Aldrighetti, L, Cescon, M, Gorgone, M, Ratti, F, Costa, G, Razionale, F, Russolillo, N, Marinelli, L, Giuffrida, M, Scotti, M, Garancini, M, De Peppo, V, De Stefano, F, Laureiro, Z, Marchitelli, I, Franceschi, A, Cosola, D, Corleone, P, Montuori, M, Salvador, L, Manzoni, A, La Barba, G, Calcagno, P, Pennacchi, L, Conticchio, M, Serenari M., Lenzi J., Cucchetti A., Cipriani F., Donadon M., Ardito F., Fazio F., Nicolini D., Iaria M., Famularo S., Perri P., Ansaloni L., Zanello M., Lai Q., Conci S., Molfino S., Ferrari C., Germani P., Zago M., Romano M., Zimmitti G., Antonucci A., Fumagalli L., Troci A., Ferraro V., Memeo R., Crespi M., Chiarelli M., Ercolani G., Hilal M. A., Zanus G., Pinotti E., Tarchi P., Griseri G., Baiocchi G. L., Ruzzenente A., Rossi M., Jovine E., Maestri M., Grazi G. L., Romano F., Dalla Valle R., Ravaioli M., Vivarelli M., Ferrero A., Giuliante F., Torzilli G., Aldrighetti L., Cescon M., Gorgone M., Ratti F., Costa G., Razionale F., Russolillo N., Marinelli L., Giuffrida M., Scotti M., Garancini M., De Peppo V., De Stefano F., Laureiro Z. L., Marchitelli I., Franceschi A., Cosola D., Corleone P., Montuori M., Salvador L., Manzoni A., La Barba G., Calcagno P., Pennacchi L., Conticchio M., Serenari, M, Lenzi, J, Cucchetti, A, Cipriani, F, Donadon, M, Ardito, F, Fazio, F, Nicolini, D, Iaria, M, Famularo, S, Perri, P, Ansaloni, L, Zanello, M, Lai, Q, Conci, S, Molfino, S, Ferrari, C, Germani, P, Zago, M, Romano, M, Zimmitti, G, Antonucci, A, Fumagalli, L, Troci, A, Ferraro, V, Memeo, R, Crespi, M, Chiarelli, M, Ercolani, G, Hilal, M, Zanus, G, Pinotti, E, Tarchi, P, Griseri, G, Baiocchi, G, Ruzzenente, A, Rossi, M, Jovine, E, Maestri, M, Grazi, G, Romano, F, Dalla Valle, R, Ravaioli, M, Vivarelli, M, Ferrero, A, Giuliante, F, Torzilli, G, Aldrighetti, L, Cescon, M, Gorgone, M, Ratti, F, Costa, G, Razionale, F, Russolillo, N, Marinelli, L, Giuffrida, M, Scotti, M, Garancini, M, De Peppo, V, De Stefano, F, Laureiro, Z, Marchitelli, I, Franceschi, A, Cosola, D, Corleone, P, Montuori, M, Salvador, L, Manzoni, A, La Barba, G, Calcagno, P, Pennacchi, L, Conticchio, M, Serenari M., Lenzi J., Cucchetti A., Cipriani F., Donadon M., Ardito F., Fazio F., Nicolini D., Iaria M., Famularo S., Perri P., Ansaloni L., Zanello M., Lai Q., Conci S., Molfino S., Ferrari C., Germani P., Zago M., Romano M., Zimmitti G., Antonucci A., Fumagalli L., Troci A., Ferraro V., Memeo R., Crespi M., Chiarelli M., Ercolani G., Hilal M. A., Zanus G., Pinotti E., Tarchi P., Griseri G., Baiocchi G. L., Ruzzenente A., Rossi M., Jovine E., Maestri M., Grazi G. L., Romano F., Dalla Valle R., Ravaioli M., Vivarelli M., Ferrero A., Giuliante F., Torzilli G., Aldrighetti L., Cescon M., Gorgone M., Ratti F., Costa G., Razionale F., Russolillo N., Marinelli L., Giuffrida M., Scotti M., Garancini M., De Peppo V., De Stefano F., Laureiro Z. L., Marchitelli I., Franceschi A., Cosola D., Corleone P., Montuori M., Salvador L., Manzoni A., La Barba G., Calcagno P., Pennacchi L., and Conticchio M.

Abstract

Objective: To evaluate the effect of a liver transplantation (LT) program on the outcomes of resectable hepatocellular carcinoma (HCC). Background: Surgical treatment of HCC includes both hepatic resection (HR) and LT. However, the presence of cirrhosis and the possibility of recurrence make the management of this disease complex and probably different according to the presence of a LT program. Methods: Patients undergoing HR for HCC between January 2005 and December 2019 were identified from a national database of HCC. The main study outcomes were major surgical complications according to the Comprehensive Complication Index, posthepatectomy liver failure (PHLF), 90-day mortality, overall survival, and disease-free survival. Secondary outcomes were salvage liver transplantation (SLT) and postrecurrence survival. Results: A total of 3202 patients were included from 25 hospitals over the study period. Three of 25 (12%) had an LT program. The presence of an LT program within a center was associated with a reduced probability of PHLF (odds ratio=0.38) but not with overall survival and disease-free survival. There was an increased probability of SLT when HR was performed in a transplant hospital (odds ratio=12.05). Among transplant-eligible patients, those who underwent LT had a significantly longer postrecurrence survival. Conclusions: This study showed that the presence of a LT program was associated with decreased PHLF rates and an increased probability to receive SLT in case of recurrence.

Published
2023

32. Prescription appropriateness of anti-diabetes drugs in elderly patients hospitalized in a clinical setting: evidence from the REPOSI Register

Author

Succurro, E, Novella, A, Nobili, A, Giofre, F, Arturi, F, Sciacqua, A, Andreozzi, F, Pietrangelo, A, Sesti, G, Perticone, F, Violi, F, Corrao, S, Marengoni, A, Tettamanti, M, Pasina, L, Franchi, C, Miglio, G, Ardoino, I, Cantiero, S, Prisco, D, Silvestri, E, Emmi, G, Bettiol, A, Mattioli, I, Mazzetti, M, Biolo, G, Zanetti, M, Bartelloni, G, Zaccari, M, Chiuch, M, Martini, I, Pirro, M, Lupattelli, G, Bianconi, V, Alcidi, R, Giotta, A, Mannarino, M, Girelli, D, Busti, F, Marchi, G, Barbagallo, M, Dominguez, L, Beneduce, V, Cacioppo, F, Natoli, G, Mularo, S, Raspanti, M, Argano, C, Cavallaro, F, Zoli, M, Orio, G, Magnolfi, E, Serafini, G, Brunori, M, Lazzari, I, Simili, A, Fabio, G, De Amicis, M, Luca, G, Scaramellini, N, Stefano, V, Leoni, S, Seghezzi, S, Di Mauro, A, Maira, D, Mancarella, M, Lucchi, T, Clerici, M, Bonini, G, Conti, F, Prolo, S, Fabrizi, M, Martelengo, M, Vigani, G, Nicolini, P, Sabatino, A, Miceli, E, Pisati, M, Pitotti, L, Antoci, V, Cambie, G, Pontremoli, R, Beccati, V, Nobili, G, Leoncini, G, Alberto, J, Cattaneo, F, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Rossi, I, Valeriani, E, D'Ardes, D, Cipollone, A, Esposito, L, Sestili, S, Angelucci, E, Mancuso, G, Calipari, D, Bartone, M, Manetti, R, Sircana, M, Berria, M, Delitala, A, Muscaritoli, M, Molfino, A, Petrillo, E, Giorgi, A, Gracin, C, Imbimbo, G, Romanelli, G, Volpini, A, Lucente, D, Manzoni, F, Pirozzi, A, Zucchelli, A, Geneletti, T, Picardi, A, Bellelli, G, Corsi, M, Antonucci, C, Sidoli, C, Principato, G, Bonfanti, A, Szabo, H, Mazzola, P, Piazzoli, A, Tassone, B, De Falco, A, Negro, E, Brenna, M, Trotta, L, Fabris, F, Bertozzi, I, Bogoni, G, Prandini, T, Ratti, F, Zurlo, C, Cerruti, L, Cosi, E, Reni, E, Manfredini, R, Boari, B, Tiseo, R, Savrie, C, Fabbian, F, Paolisso, G, Catalano, C, Meo, I, Sabba, C, Suppressa, P, De Vincenzo, G, Comitangelo, A, Amoruso, E, Custodero, C, Re, G, Barnaba, I, Schilardi, A, Fenoglio, L, Falcetta, A, D'Aniano, S, Tiraboschi, S, Cespiati, A, Oberti, G, Sigon, G, Cinque, F, Colavolpe, L, Curra, J, Alletto, F, Benzoni, G, Peyvandi, F, Rossio, R, Colombo, G, Agosti, P, Pagliaro, E, Semproni, E, Canetta, C, Monzani, V, Savojardo, V, Ceriani, G, Folli, C, Tognin, T, Purrello, F, Pino, A, Piro, S, Rozzini, R, Falanga, L, Boffelli, S, Ferrandina, C, Mazzeo, F, Spazzini, E, Cono, G, Cesaroni, G, Perri, L, Guasti, L, Rotunno, F, Castiglioni, L, Maresca, A, Squizzato, A, Campiotti, L, Grossi, A, Dentali, F, Behnke, V, Perticone, M, Maio, R, Scozzafava, A, Condoleo, V, Clausi, E, Armentaro, G, Panza, A, Stanghellini, V, Ruggeri, E, Vecchio, S, Benzoni, I, Minisola, S, Colangelo, L, Cilli, M, Labbadia, G, Pepe, J, Castellino, P, Zanoli, L, Gaudio, A, Xourafa, A, Spichetti, C, Torre, S, Gennaro, A, Ballestrero, A, Ferrando, F, Gonella, R, Cerminara, D, Setti, P, Traversa, C, Scarsi, C, Famularo, G, Tarsitani, P, Morretti, T, Aglitti, A, Giacco, S, Firinu, D, Costanzo, G, Chessa, S, Montalto, G, Licata, A, Rizzo, A, Corica, F, Basile, G, Catalano, A, Bellone, F, Principato, C, Cocuzza, A, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Ticinesi, A, Nouvenne, A, Pirisi, M, Sola, D, Bellan, M, Quadri, R, Larovere, E, Novelli, M, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Napoli, F, Aiello, I, Salvatore, T, Monaco, L, Ricozzi, C, Coviello, F, Catalini, C, Pilotto, A, Indiano, I, Gandolfo, F, Gonella, D, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Durante, V, Tirotta, D, Eusebi, G, Tresoldi, M, Bozzolo, E, Damanti, S, Porta, M, Gino, M, Pari, B, Pace, E, Succurro E., Novella A., Nobili A., Giofre F., Arturi F., Sciacqua A., Andreozzi F., Pietrangelo A., Sesti G., Perticone F., Violi F., Corrao S., Marengoni A., Tettamanti M., Pasina L., Franchi C., Miglio G., Ardoino I., Cantiero S., Prisco D., Silvestri E., Emmi G., Bettiol A., Mattioli I., Mazzetti M., Biolo G., Zanetti M., Bartelloni G., Zaccari M., Chiuch M., Martini I., Pirro M., Lupattelli G., Bianconi V., Alcidi R., Giotta A., Mannarino M. R., Girelli D., Busti F., Marchi G., Barbagallo M., Dominguez L., Beneduce V., Cacioppo F., Natoli G., Mularo S., Raspanti M., Argano C., Cavallaro F., Zoli M., Orio G., Magnolfi E., Serafini G., Brunori M., Lazzari I., Simili A., Fabio G., De Amicis M. M., Luca G., Scaramellini N., Stefano V., Leoni S., Seghezzi S., Di Mauro A. D., Maira D., Mancarella M., Lucchi T., Clerici M., Bonini G., Conti F., Prolo S., Fabrizi M., Martelengo M., Vigani G., Nicolini P., Sabatino A., Miceli E., Pisati M., Pitotti L., Antoci V., Cambie G., Pontremoli R., Beccati V., Nobili G., Leoncini G., Alberto J., Cattaneo F., Anastasio L., Sofia L., Carbone M., Cipollone F., Rossi I., Valeriani E., D'Ardes D., Cipollone A., Esposito L., Sestili S., Angelucci E., Mancuso G., Calipari D., Bartone M., Manetti R., Sircana M., Berria M., Delitala A., Muscaritoli M., Molfino A., Petrillo E., Giorgi A., Gracin C., Imbimbo G., Romanelli G., Volpini A., Lucente D., Manzoni F., Pirozzi A., Zucchelli A., Geneletti T., Picardi A., Bellelli G., Corsi M., Antonucci C., Sidoli C., Principato G., Bonfanti A., Szabo H., Mazzola P., Piazzoli A., Tassone B., De Falco A. B. T., Negro E., Brenna M., Trotta L., Fabris F., Bertozzi I., Bogoni G., Prandini T., Ratti F., Zurlo C., Cerruti L., Cosi E., Reni E., Manfredini R., Boari B., Tiseo R., Savrie C., Fabbian F., Paolisso G., Catalano C., Meo I., Sabba C., Suppressa P., De Vincenzo G. M., Comitangelo A., Amoruso E., Custodero C., Re G., Barnaba I., Schilardi A., Fenoglio L., Falcetta A., D'Aniano S., Tiraboschi S., Cespiati A., Oberti G., Sigon G., Cinque F., Colavolpe L., Curra J., Alletto F., Benzoni G., Peyvandi F., Rossio R., Colombo G., Agosti P., Pagliaro E., Semproni E., Canetta C., Monzani V., Savojardo V., Ceriani G., Folli C., Tognin T., Purrello F., Pino A., Piro S., Rozzini R., Falanga L., Boffelli S., Ferrandina C., Mazzeo F., Spazzini E., Cono G., Cesaroni G., Perri L., Guasti L., Rotunno F., Castiglioni L., Maresca A., Squizzato A., Campiotti L., Grossi A., Dentali F., Behnke V., Perticone M., Maio R., Scozzafava A., Condoleo V., Clausi E., Armentaro G., Panza A., Stanghellini V., Ruggeri E., Vecchio S., Benzoni I., Minisola S., Colangelo L., Cilli M., Labbadia G., Pepe J., Castellino P., Zanoli L., Gaudio A., Xourafa A., Spichetti C., Torre S., Gennaro A., Ballestrero A., Ferrando F., Gonella R., Cerminara D., Setti P., Traversa C., Scarsi C., Famularo G., Tarsitani P., Morretti T., Aglitti A., Giacco S., Firinu D., Costanzo G., Chessa S., Montalto G., Licata A., Rizzo A., Corica F., Basile G., Catalano A., Bellone F., Principato C., Cocuzza A., Mecocci P., Ruggiero C., Boccardi V., Meschi T., Ticinesi A., Nouvenne A., Pirisi M., Sola D., Bellan M., Quadri R., Larovere E., Novelli M., Simeone E., Scurti R., Tolloso F., Tarquini R., Valoriani A., Dolenti S., Vannini G., Volpi R., Bocchi P., Vignali A., Harari S., Lonati C., Napoli F., Aiello I., Salvatore T., Monaco L., Ricozzi C., Coviello F., Catalini C., Pilotto A., Indiano I., Gandolfo F., Gonella D., Nuti R., Valenti R., Ruvio M., Cappelli S., Palazzuoli A., Durante V., Tirotta D., Eusebi G., Tresoldi M., Bozzolo E., Damanti S., Porta M., Gino M., Pari B., Pace E., Succurro, E, Novella, A, Nobili, A, Giofre, F, Arturi, F, Sciacqua, A, Andreozzi, F, Pietrangelo, A, Sesti, G, Perticone, F, Violi, F, Corrao, S, Marengoni, A, Tettamanti, M, Pasina, L, Franchi, C, Miglio, G, Ardoino, I, Cantiero, S, Prisco, D, Silvestri, E, Emmi, G, Bettiol, A, Mattioli, I, Mazzetti, M, Biolo, G, Zanetti, M, Bartelloni, G, Zaccari, M, Chiuch, M, Martini, I, Pirro, M, Lupattelli, G, Bianconi, V, Alcidi, R, Giotta, A, Mannarino, M, Girelli, D, Busti, F, Marchi, G, Barbagallo, M, Dominguez, L, Beneduce, V, Cacioppo, F, Natoli, G, Mularo, S, Raspanti, M, Argano, C, Cavallaro, F, Zoli, M, Orio, G, Magnolfi, E, Serafini, G, Brunori, M, Lazzari, I, Simili, A, Fabio, G, De Amicis, M, Luca, G, Scaramellini, N, Stefano, V, Leoni, S, Seghezzi, S, Di Mauro, A, Maira, D, Mancarella, M, Lucchi, T, Clerici, M, Bonini, G, Conti, F, Prolo, S, Fabrizi, M, Martelengo, M, Vigani, G, Nicolini, P, Sabatino, A, Miceli, E, Pisati, M, Pitotti, L, Antoci, V, Cambie, G, Pontremoli, R, Beccati, V, Nobili, G, Leoncini, G, Alberto, J, Cattaneo, F, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Rossi, I, Valeriani, E, D'Ardes, D, Cipollone, A, Esposito, L, Sestili, S, Angelucci, E, Mancuso, G, Calipari, D, Bartone, M, Manetti, R, Sircana, M, Berria, M, Delitala, A, Muscaritoli, M, Molfino, A, Petrillo, E, Giorgi, A, Gracin, C, Imbimbo, G, Romanelli, G, Volpini, A, Lucente, D, Manzoni, F, Pirozzi, A, Zucchelli, A, Geneletti, T, Picardi, A, Bellelli, G, Corsi, M, Antonucci, C, Sidoli, C, Principato, G, Bonfanti, A, Szabo, H, Mazzola, P, Piazzoli, A, Tassone, B, De Falco, A, Negro, E, Brenna, M, Trotta, L, Fabris, F, Bertozzi, I, Bogoni, G, Prandini, T, Ratti, F, Zurlo, C, Cerruti, L, Cosi, E, Reni, E, Manfredini, R, Boari, B, Tiseo, R, Savrie, C, Fabbian, F, Paolisso, G, Catalano, C, Meo, I, Sabba, C, Suppressa, P, De Vincenzo, G, Comitangelo, A, Amoruso, E, Custodero, C, Re, G, Barnaba, I, Schilardi, A, Fenoglio, L, Falcetta, A, D'Aniano, S, Tiraboschi, S, Cespiati, A, Oberti, G, Sigon, G, Cinque, F, Colavolpe, L, Curra, J, Alletto, F, Benzoni, G, Peyvandi, F, Rossio, R, Colombo, G, Agosti, P, Pagliaro, E, Semproni, E, Canetta, C, Monzani, V, Savojardo, V, Ceriani, G, Folli, C, Tognin, T, Purrello, F, Pino, A, Piro, S, Rozzini, R, Falanga, L, Boffelli, S, Ferrandina, C, Mazzeo, F, Spazzini, E, Cono, G, Cesaroni, G, Perri, L, Guasti, L, Rotunno, F, Castiglioni, L, Maresca, A, Squizzato, A, Campiotti, L, Grossi, A, Dentali, F, Behnke, V, Perticone, M, Maio, R, Scozzafava, A, Condoleo, V, Clausi, E, Armentaro, G, Panza, A, Stanghellini, V, Ruggeri, E, Vecchio, S, Benzoni, I, Minisola, S, Colangelo, L, Cilli, M, Labbadia, G, Pepe, J, Castellino, P, Zanoli, L, Gaudio, A, Xourafa, A, Spichetti, C, Torre, S, Gennaro, A, Ballestrero, A, Ferrando, F, Gonella, R, Cerminara, D, Setti, P, Traversa, C, Scarsi, C, Famularo, G, Tarsitani, P, Morretti, T, Aglitti, A, Giacco, S, Firinu, D, Costanzo, G, Chessa, S, Montalto, G, Licata, A, Rizzo, A, Corica, F, Basile, G, Catalano, A, Bellone, F, Principato, C, Cocuzza, A, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Ticinesi, A, Nouvenne, A, Pirisi, M, Sola, D, Bellan, M, Quadri, R, Larovere, E, Novelli, M, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Napoli, F, Aiello, I, Salvatore, T, Monaco, L, Ricozzi, C, Coviello, F, Catalini, C, Pilotto, A, Indiano, I, Gandolfo, F, Gonella, D, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Durante, V, Tirotta, D, Eusebi, G, Tresoldi, M, Bozzolo, E, Damanti, S, Porta, M, Gino, M, Pari, B, Pace, E, Succurro E., Novella A., Nobili A., Giofre F., Arturi F., Sciacqua A., Andreozzi F., Pietrangelo A., Sesti G., Perticone F., Violi F., Corrao S., Marengoni A., Tettamanti M., Pasina L., Franchi C., Miglio G., Ardoino I., Cantiero S., Prisco D., Silvestri E., Emmi G., Bettiol A., Mattioli I., Mazzetti M., Biolo G., Zanetti M., Bartelloni G., Zaccari M., Chiuch M., Martini I., Pirro M., Lupattelli G., Bianconi V., Alcidi R., Giotta A., Mannarino M. R., Girelli D., Busti F., Marchi G., Barbagallo M., Dominguez L., Beneduce V., Cacioppo F., Natoli G., Mularo S., Raspanti M., Argano C., Cavallaro F., Zoli M., Orio G., Magnolfi E., Serafini G., Brunori M., Lazzari I., Simili A., Fabio G., De Amicis M. M., Luca G., Scaramellini N., Stefano V., Leoni S., Seghezzi S., Di Mauro A. D., Maira D., Mancarella M., Lucchi T., Clerici M., Bonini G., Conti F., Prolo S., Fabrizi M., Martelengo M., Vigani G., Nicolini P., Sabatino A., Miceli E., Pisati M., Pitotti L., Antoci V., Cambie G., Pontremoli R., Beccati V., Nobili G., Leoncini G., Alberto J., Cattaneo F., Anastasio L., Sofia L., Carbone M., Cipollone F., Rossi I., Valeriani E., D'Ardes D., Cipollone A., Esposito L., Sestili S., Angelucci E., Mancuso G., Calipari D., Bartone M., Manetti R., Sircana M., Berria M., Delitala A., Muscaritoli M., Molfino A., Petrillo E., Giorgi A., Gracin C., Imbimbo G., Romanelli G., Volpini A., Lucente D., Manzoni F., Pirozzi A., Zucchelli A., Geneletti T., Picardi A., Bellelli G., Corsi M., Antonucci C., Sidoli C., Principato G., Bonfanti A., Szabo H., Mazzola P., Piazzoli A., Tassone B., De Falco A. B. T., Negro E., Brenna M., Trotta L., Fabris F., Bertozzi I., Bogoni G., Prandini T., Ratti F., Zurlo C., Cerruti L., Cosi E., Reni E., Manfredini R., Boari B., Tiseo R., Savrie C., Fabbian F., Paolisso G., Catalano C., Meo I., Sabba C., Suppressa P., De Vincenzo G. M., Comitangelo A., Amoruso E., Custodero C., Re G., Barnaba I., Schilardi A., Fenoglio L., Falcetta A., D'Aniano S., Tiraboschi S., Cespiati A., Oberti G., Sigon G., Cinque F., Colavolpe L., Curra J., Alletto F., Benzoni G., Peyvandi F., Rossio R., Colombo G., Agosti P., Pagliaro E., Semproni E., Canetta C., Monzani V., Savojardo V., Ceriani G., Folli C., Tognin T., Purrello F., Pino A., Piro S., Rozzini R., Falanga L., Boffelli S., Ferrandina C., Mazzeo F., Spazzini E., Cono G., Cesaroni G., Perri L., Guasti L., Rotunno F., Castiglioni L., Maresca A., Squizzato A., Campiotti L., Grossi A., Dentali F., Behnke V., Perticone M., Maio R., Scozzafava A., Condoleo V., Clausi E., Armentaro G., Panza A., Stanghellini V., Ruggeri E., Vecchio S., Benzoni I., Minisola S., Colangelo L., Cilli M., Labbadia G., Pepe J., Castellino P., Zanoli L., Gaudio A., Xourafa A., Spichetti C., Torre S., Gennaro A., Ballestrero A., Ferrando F., Gonella R., Cerminara D., Setti P., Traversa C., Scarsi C., Famularo G., Tarsitani P., Morretti T., Aglitti A., Giacco S., Firinu D., Costanzo G., Chessa S., Montalto G., Licata A., Rizzo A., Corica F., Basile G., Catalano A., Bellone F., Principato C., Cocuzza A., Mecocci P., Ruggiero C., Boccardi V., Meschi T., Ticinesi A., Nouvenne A., Pirisi M., Sola D., Bellan M., Quadri R., Larovere E., Novelli M., Simeone E., Scurti R., Tolloso F., Tarquini R., Valoriani A., Dolenti S., Vannini G., Volpi R., Bocchi P., Vignali A., Harari S., Lonati C., Napoli F., Aiello I., Salvatore T., Monaco L., Ricozzi C., Coviello F., Catalini C., Pilotto A., Indiano I., Gandolfo F., Gonella D., Nuti R., Valenti R., Ruvio M., Cappelli S., Palazzuoli A., Durante V., Tirotta D., Eusebi G., Tresoldi M., Bozzolo E., Damanti S., Porta M., Gino M., Pari B., and Pace E.

Abstract

Diabetes is an increasing global health burden with the highest prevalence (24.0%) observed in elderly people. Older diabetic adults have a greater risk of hospitalization and several geriatric syndromes than older nondiabetic adults. For these conditions, special care is required in prescribing therapies including anti- diabetes drugs. Aim of this study was to evaluate the appropriateness and the adherence to safety recommendations in the prescriptions of glucose-lowering drugs in hospitalized elderly patients with diabetes. Data for this cross-sectional study were obtained from the REgistro POliterapie–Società Italiana Medicina Interna (REPOSI) that collected clinical information on patients aged ≥ 65 years acutely admitted to Italian internal medicine and geriatric non-intensive care units (ICU) from 2010 up to 2019. Prescription appropriateness was assessed according to the 2019 AGS Beers Criteria and anti-diabetes drug data sheets.Among 5349 patients, 1624 (30.3%) had diagnosis of type 2 diabetes. At admission, 37.7% of diabetic patients received treatment with metformin, 37.3% insulin therapy, 16.4% sulfonylureas, and 11.4% glinides. Surprisingly, only 3.1% of diabetic patients were treated with new classes of anti- diabetes drugs. According to prescription criteria, at admission 15.4% of patients treated with metformin and 2.6% with sulfonylureas received inappropriately these treatments. At discharge, the inappropriateness of metformin therapy decreased (10.2%, P < 0.0001). According to Beers criteria, the inappropriate prescriptions of sulfonylureas raised to 29% both at admission and at discharge. This study shows a poor adherence to current guidelines on diabetes management in hospitalized elderly people with a high prevalence of inappropriate use of sulfonylureas according to the Beers criteria.

Published
2023

33. Survival benefit of second line therapies for recurrent hepatocellular carcinoma: repeated hepatectomy, thermoablation and second-line transplant referral in a real life national scenario

Author

Famularo, S, Cillo, U, Lauterio, A, Donadon, M, Vitale, A, Serenari, M, Cipriani, F, Fazio, F, Giuffrida, M, Ardito, F, Dominioni, T, Garancini, M, Lai, Q, Nicolini, D, Molfino, S, Perri, P, Pinotti, E, Conci, S, Ferrari, C, Zanello, M, Patauner, S, Zimmitti, G, Germani, P, Chiarelli, M, Romano, M, De Angelis, M, La Barba, G, Troci, A, Ferraro, V, Izzo, F, Antonucci, A, Belli, A, Memeo, R, Crespi, M, Ercolani, G, Boccia, L, Zanus, G, Tarchi, P, Hilal, M, Frena, A, Jovine, E, Griseri, G, Ruzzenente, A, Zago, M, Grazi, G, Baiocchi, G, Vivarelli, M, Rossi, M, Romano, F, Maestri, M, Giuliante, F, Valle, R, Ferrero, A, Aldrighetti, L, De Carlis, L, Cescon, M, Torzilli, G, Milana, F, Bertacco, A, De Carlis, R, Ratti, F, Russolillo, N, Iaria, M, Razionale, F, Tartaglia, G, Ciulli, C, Carissimi, F, Laureiro, Z, Marinelli, L, Depeppo, V, Montuori, M, Marchitelli, I, Franceschi, A, Notte, F, Manzoni, A, Cosola, D, Corleone, P, Fumagalli, L, Salvador, L, Mantovani, G, Cucchetti, A, Cammarata, F, Conticchio, M, Patrone, R, Bernasconi, D, Famularo S., Cillo U., Lauterio A., Donadon M., Vitale A., Serenari M., Cipriani F., Fazio F., Giuffrida M., Ardito F., Dominioni T., Garancini M., Lai Q., Nicolini D., Molfino S., Perri P., Pinotti E., Conci S., Ferrari C., Zanello M., Patauner S., Zimmitti G., Germani P., Chiarelli M., Romano M., De Angelis M., La Barba G., Troci A., Ferraro V., Izzo F., Antonucci A., Belli A., Memeo R., Crespi M., Ercolani G., Boccia L., Zanus G., Tarchi P., Hilal M. A., Frena A., Jovine E., Griseri G., Ruzzenente A., Zago M., Grazi G., Baiocchi G. L., Vivarelli M., Rossi M., Romano F., Maestri M., Giuliante F., Valle R. D., Ferrero A., Aldrighetti L., De Carlis L., Cescon M., Torzilli G., Milana F., Bertacco A., De Carlis R., Ratti F., Russolillo N., Iaria M., Razionale F., Tartaglia G., Ciulli C., Carissimi F., Laureiro Z. L., Marinelli L., DePeppo V., Montuori M., Marchitelli I., Franceschi A., Notte F., Manzoni A., Cosola D., Corleone P., Fumagalli L., Salvador L., Mantovani G., Cucchetti A., Cammarata F., Conticchio M., Patrone R., Bernasconi D. P., Famularo, S, Cillo, U, Lauterio, A, Donadon, M, Vitale, A, Serenari, M, Cipriani, F, Fazio, F, Giuffrida, M, Ardito, F, Dominioni, T, Garancini, M, Lai, Q, Nicolini, D, Molfino, S, Perri, P, Pinotti, E, Conci, S, Ferrari, C, Zanello, M, Patauner, S, Zimmitti, G, Germani, P, Chiarelli, M, Romano, M, De Angelis, M, La Barba, G, Troci, A, Ferraro, V, Izzo, F, Antonucci, A, Belli, A, Memeo, R, Crespi, M, Ercolani, G, Boccia, L, Zanus, G, Tarchi, P, Hilal, M, Frena, A, Jovine, E, Griseri, G, Ruzzenente, A, Zago, M, Grazi, G, Baiocchi, G, Vivarelli, M, Rossi, M, Romano, F, Maestri, M, Giuliante, F, Valle, R, Ferrero, A, Aldrighetti, L, De Carlis, L, Cescon, M, Torzilli, G, Milana, F, Bertacco, A, De Carlis, R, Ratti, F, Russolillo, N, Iaria, M, Razionale, F, Tartaglia, G, Ciulli, C, Carissimi, F, Laureiro, Z, Marinelli, L, Depeppo, V, Montuori, M, Marchitelli, I, Franceschi, A, Notte, F, Manzoni, A, Cosola, D, Corleone, P, Fumagalli, L, Salvador, L, Mantovani, G, Cucchetti, A, Cammarata, F, Conticchio, M, Patrone, R, Bernasconi, D, Famularo S., Cillo U., Lauterio A., Donadon M., Vitale A., Serenari M., Cipriani F., Fazio F., Giuffrida M., Ardito F., Dominioni T., Garancini M., Lai Q., Nicolini D., Molfino S., Perri P., Pinotti E., Conci S., Ferrari C., Zanello M., Patauner S., Zimmitti G., Germani P., Chiarelli M., Romano M., De Angelis M., La Barba G., Troci A., Ferraro V., Izzo F., Antonucci A., Belli A., Memeo R., Crespi M., Ercolani G., Boccia L., Zanus G., Tarchi P., Hilal M. A., Frena A., Jovine E., Griseri G., Ruzzenente A., Zago M., Grazi G., Baiocchi G. L., Vivarelli M., Rossi M., Romano F., Maestri M., Giuliante F., Valle R. D., Ferrero A., Aldrighetti L., De Carlis L., Cescon M., Torzilli G., Milana F., Bertacco A., De Carlis R., Ratti F., Russolillo N., Iaria M., Razionale F., Tartaglia G., Ciulli C., Carissimi F., Laureiro Z. L., Marinelli L., DePeppo V., Montuori M., Marchitelli I., Franceschi A., Notte F., Manzoni A., Cosola D., Corleone P., Fumagalli L., Salvador L., Mantovani G., Cucchetti A., Cammarata F., Conticchio M., Patrone R., and Bernasconi D. P.

Abstract

Background: Despite second-line transplant(SLT) for recurrent hepatocellular carcinoma(rHCC) leads to the longest survival after recurrence(SAR), its real applicability has never been reported. The aim was to compare the SAR of SLT versus repeated hepatectomy and thermoablation(CUR group). Methods: Patients were enrolled from the Italian register HE.RC.O.LE.S. between 2008 and 2021. Two groups were created: CUR versus SLT. A propensity score matching (PSM) was run to balance the groups. Results: 743 patients were enrolled, CUR = 611 and SLT = 132. Median age at recurrence was 71(IQR 6575) years old and 60(IQR 53-64, p < 0.001) for CUR and SLT respectively. After PSM, median SAR for CUR was 43 months(95%CI = 37 – 93) and not reached for SLT(p < 0.001). SLT patients gained a survival benefit of 9.4 months if compared with CUR. MilanCriteria(MC)-In patients were 82.7% of the CUR group. SLT(HR 0.386, 95%CI = 0.23 – 0.63, p < 0.001) and the MELD score(HR 1.169, 95%CI = 1.07 – 1.27, p < 0.001) were the only predictors of mortality. In case of MC-Out, the only predictor of mortality was the number of nodules at recurrence(HR 1.45, 95%CI= 1.09 – 1.93, p = 0.011). Conclusion: It emerged an important transplant under referral in favour of repeated hepatectomy or thermoablation. In patients with MC-Out relapse, the benefit of SLT over CUR was not observed.

Published
2023

34. Evolution of minimally invasive techniques and surgical outcomes of ALPPS in Italy: a comprehensive trend analysis over 10 years from a national prospective registry

Author

Serenari, M, Ratti, F, Guglielmo, N, Zanello, M, Mocchegiani, F, Lenzi, J, Colledan, M, Mazzaferro, V, Cillo, U, Ferrero, A, Cescon, M, Di Benedetto, F, Massani, M, Grazi, G, Valle, R, Vivarelli, M, Ettorre, G, Aldrighetti, L, Jovine, E, Serenari M., Ratti F., Guglielmo N., Zanello M., Mocchegiani F., Lenzi J., Colledan M., Mazzaferro V., Cillo U., Ferrero A., Cescon M., Di Benedetto F., Massani M., Grazi G., Valle R. D., Vivarelli M., Ettorre G. M., Aldrighetti L., Jovine E., Serenari, M, Ratti, F, Guglielmo, N, Zanello, M, Mocchegiani, F, Lenzi, J, Colledan, M, Mazzaferro, V, Cillo, U, Ferrero, A, Cescon, M, Di Benedetto, F, Massani, M, Grazi, G, Valle, R, Vivarelli, M, Ettorre, G, Aldrighetti, L, Jovine, E, Serenari M., Ratti F., Guglielmo N., Zanello M., Mocchegiani F., Lenzi J., Colledan M., Mazzaferro V., Cillo U., Ferrero A., Cescon M., Di Benedetto F., Massani M., Grazi G., Valle R. D., Vivarelli M., Ettorre G. M., Aldrighetti L., and Jovine E.

Abstract

Background: Since 2012, Associating Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS) has encountered several modifications of its original technique. The primary endpoint of this study was to analyze the trend of ALPPS in Italy over a 10-year period. The secondary endpoint was to evaluate factors affecting the risk of morbidity/mortality/post-hepatectomy liver failure (PHLF). Methods: Data of patients submitted to ALPPS between 2012 and 2021 were identified from the ALPPS Italian Registry and evaluation of time trends was performed. Results: From 2012 to 2021, a total of 268 ALPPS were performed within 17 centers. The number of ALPPS divided by the total number of liver resections performed by each center slightly declined (APC = - 2.0%, p = 0.111). Minimally invasive (MI) approach significantly increased over the years (APC = + 49.5%, p = 0.002). According to multivariable analysis, MI completion of stage 1 was protective against 90-day mortality (OR = 0.05, p = 0.040) as well as enrollment within high-volume centers for liver surgery (OR = 0.32, p = 0.009). Use of interstage hepatobiliary scintigraphy (HBS) and biliary tumors were independent predictors of PHLF. Conclusions: This national study showed that use of ALPPS only slightly declined over the years with an increased use of MI techniques, leading to lower 90-day mortality. PHLF still remains an open issue.

Published
2023

35. CHEOPS and TESS view of the ultra-short-period super-Earth TOI-561 b

Author

Patel, J. A., primary, Egger, J. A., additional, Wilson, T. G., additional, Bourrier, V., additional, Carone, L., additional, Beck, M., additional, Ehrenreich, D., additional, Sousa, S. G., additional, Benz, W., additional, Brandeker, A., additional, Deline, A., additional, Alibert, Y., additional, Lam, K. W. F., additional, Lendl, M., additional, Alonso, R., additional, Anglada, G., additional, Bárczy, T., additional, Barrado, D., additional, Barros, S. C. C., additional, Baumjohann, W., additional, Beck, T., additional, Billot, N., additional, Bonfils, X., additional, Broeg, C., additional, Busch, M.-D., additional, Cabrera, J., additional, Charnoz, S., additional, Collier Cameron, A., additional, Csizmadia, Sz., additional, Davies, M. B., additional, Deleuil, M., additional, Delrez, L., additional, Demangeon, O. D. S., additional, Demory, B.-O., additional, Erikson, A., additional, Fortier, A., additional, Fossati, L., additional, Fridlund, M., additional, Gandolfi, D., additional, Gillon, M., additional, Güdel, M., additional, Heng, K., additional, Hoyer, S., additional, Isaak, K. G., additional, Kiss, L. L., additional, Kopp, E., additional, Laskar, J., additional, Lecavelier des Etangs, A., additional, Lovis, C., additional, Magrin, D., additional, Maxted, P. F. L., additional, Nascimbeni, V., additional, Olofsson, G., additional, Ottensamer, R., additional, Pagano, I., additional, Pallé, E., additional, Peter, G., additional, Piotto, G., additional, Pollacco, D., additional, Queloz, D., additional, Ragazzoni, R., additional, Rando, N., additional, Ratti, F., additional, Rauer, H., additional, Ribas, I., additional, Santos, N. C., additional, Scandariato, G., additional, Ségransan, D., additional, Simon, A. E., additional, Smith, A. M. S., additional, Steller, M., additional, Szabó, Gy. M., additional, Thomas, N., additional, Udry, S., additional, Ulmer, B., additional, Van Grootel, V., additional, Viotto, V., additional, and Walton, N. A., additional

Published
2023
Full Text
View/download PDF

36. LHS 1903 provides evidence for gas-depleted formation of planets around M-dwarfs

Author

Wilson, Thomas, primary, Simpson, Anna, additional, Cameron, Andrew Collier, additional, Cloutier, Ryan, additional, Adibekyan, Vardan, additional, John, Ancy Anna, additional, Alibert, Y, additional, Stalport, Manu, additional, Egger, J, additional, Bonfanti, Andrea, additional, Billot, Nicolas, additional, Guterman, Pascal, additional, Maxted, Pierre, additional, Simon, Attila, additional, Sousa, Sergio, additional, Fridlund, Malcolm, additional, Beck, M, additional, Bekkelien, Anja, additional, Salmon, S, additional, Grootel, Valerie Van, additional, Fossati, Luca, additional, Mustill, Alexander, additional, Osborn, Hugh, additional, Zingales, Tiziano, additional, Hooton, M, additional, Affer, Laura, additional, Aigrain, Suzanne, additional, Alonso, Roi, additional, Anglada-Escude, G, additional, Antoniadis-Karnavas, Alexandros, additional, Barczy, T, additional, Barrado, David, additional, Barros, Susana, additional, Baumjohann, Wolfgang, additional, Beck, T, additional, Benz, W, additional, Biondi, Federico, additional, Bonfils, Xavier, additional, Borsato, Luca, additional, Brandeker, Alexis, additional, Broeg, Christopher, additional, Buchhave, Lars, additional, Buder, Maximilian, additional, Cabrera, Juan, additional, Gaxiola, S Carrazco, additional, Charnoz, Sébastien, additional, Ciardi, David, additional, Collins, Karen, additional, Collins, Kevin, additional, Cosentino, Rosario, additional, Csizmadia, Szilard, additional, Cubillos, P, additional, Dalal, Shweta, additional, Damasso, Mario, additional, Davenport, James, additional, Davies, Melvyn, additional, Deleuil, Magali, additional, Delrez, L, additional, Demangeon, Olivier, additional, Demory, Brice-Olivier, additional, DiTomasso, Victoria, additional, Dragomir, Diana, additional, Dressing, Courtney, additional, Dumusque, Xavier, additional, Ehrenreich, David, additional, Erikson, Anders, additional, Esparza-Borges, Emma, additional, Fortier, Andrea, additional, Fukuda, Izuru, additional, Fukui, Akihiko, additional, Gandolfi, Davide, additional, Ghedina, Adriano, additional, Giacalone, Steven, additional, Gill, Holden, additional, Gillon, Michaël, additional, Chew, Y Gomez Maqueo, additional, Güdel, Manuel, additional, Guerra, Pere, additional, Günther, Maximilian, additional, Hara, Nathan, additional, Harutyunyan, Avet, additional, Hayashi, Yuya, additional, Haywood, Raphaëlle, additional, Holcomb, Rae, additional, Horne, Keith, additional, Hoyer, S, additional, Huang, Chelsea, additional, Ikoma, Masahiro, additional, Isaak, K, additional, Jackman, James, additional, Jenkins, Jon, additional, Jensen, Eric, additional, Jontof-Hutter, Daniel, additional, Kawai, Yugo, additional, Kiss, Laszlo, additional, Lakeland, Ben, additional, Laskar, J, additional, Latham, David, additional, des Etangs, Alain Lecavelier, additional, Leleu, Adrien, additional, Lendl, Monika, additional, de Leon, J, additional, Lienhard, Florian, additional, López-Morales, Mercedes, additional, Lovis, Christophe, additional, Lund, Michael, additional, Luque, Rafael, additional, Magrin, D, additional, Malavolta, Luca, additional, Fiorenzano, Aldo, additional, Mayo, Andrew, additional, Mayor, Michel, additional, Mordasini, C, additional, Mortier, Annelies, additional, Murgas, Felipe, additional, Narita, Norio, additional, Nascimbeni, Valerio, additional, Nicholson, Belinda, additional, Olofsson, Göran, additional, Ottensamer, Roland, additional, Pagano, Isabella, additional, Palethorpe, Larissa, additional, Palle, Enric, additional, Parviainen, Hannu, additional, Pedani, Marco, additional, Pepe, Francesco, additional, Peter, Gisbert, additional, Pinamonti, Matteo, additional, Piotto, Giampaolo, additional, Pollacco, Don, additional, Poretti, Ennio, additional, Queloz, Didier, additional, Quinn, Sam, additional, Ragazzoni, R, additional, Rando, N, additional, Rapetti, David, additional, Ratti, F, additional, Rauer, Heike, additional, Rescigno, Federica, additional, Ribas, Ignasi, additional, Rice, William, additional, Ricker, George, additional, Robertson, Paul, additional, de Roche, Thierry, additional, Sabin, L, additional, Santos, Nuno, additional, Sasselov, Dimitar, additional, Savel, Arjun, additional, Scandariato, Gaetano, additional, Schanche, Nicole, additional, Schroffenegger, Urs, additional, Schwarz, Richard, additional, Seager, Sara, additional, Sefako, Ramotholo, additional, Ségransan, Damien, additional, Shporer, Avi, additional, Silva, André, additional, Smith, Alexis, additional, Sozzetti, Alessandro, additional, Steller, Manfred, additional, Szabo, Gyula, additional, Tamura, Motohide, additional, Thomas, Nicolas, additional, Tuson, Amy, additional, Udry, Stéphane, additional, Vanderburg, Andrew, additional, Vanderspek, Roland, additional, Venturini, J, additional, Verrecchia, Francesco, additional, Walton, Nicholas, additional, Watson, Christopher, additional, Wells, Robert, additional, Winn, Joshua, additional, Zambelli, Roberto, additional, and Ziegler, Carl, additional

Published
2023
Full Text
View/download PDF

41. TESS and CHEOPS discover two warm sub-Neptunes transiting the bright K-dwarf HD 15906

Author

Tuson, A, Queloz, D, Osborn, H P, Wilson, T G, Hooton, M J, Beck, M, Lendl, M, Olofsson, G, Fortier, A, Bonfanti, A, Brandeker, A, Buchhave, L A, Collier Cameron, A, Ciardi, D R, Collins, K A, Gandolfi, D, Garai, Z, Giacalone, S, Gomes da Silva, J, Howell, S B, Patel, J A, Persson, C M, Serrano, L M, Sousa, S G, Ulmer-Moll, S, Vanderburg, A, Ziegler, C, Alibert, Y, Alonso, R, Anglada, G, Bárczy, T, Barrado Navascues, D, Barros, S C C, Baumjohann, W, Beck, T, Benz, W, Billot, N, Bonfils, X, Borsato, L, Broeg, C, Cabrera, J, Charnoz, S, Conti, D M, Csizmadia, Sz, Cubillos, P E, Davies, M B, Deleuil, M, Delrez, L, Demangeon, O D S, Demory, B-O, Dragomir, D, Dressing, C D, Ehrenreich, D, Erikson, A, Essack, Z, Farinato, J, Fossati, L, Fridlund, M, Furlan, E, Gill, H, Gillon, M, Gnilka, C L, Gonzales, E, Güdel, M, Günther, M N, Hoyer, S, Isaak, K G, Jenkins, J M, Kiss, L L, Laskar, J, Latham, D W, Law, N, Lecavelier des Etangs, A, Curto, G Lo, Lovis, C, Luque, R, Magrin, D, Mann, A W, Maxted, P F L, Mayor, M, McDermott, S, Mecina, M, Mordasini, C, Mortier, A, Nascimbeni, V, Ottensamer, R, Pagano, I, Pallé, E, Peter, G, Piotto, G, Pollacco, D, Pritchard, T, Ragazzoni, R, Rando, N, Ratti, F, Rauer, H, Ribas, I, Ricker, G R, Rieder, M, Santos, N C, Savel, A B, Scandariato, G, Schwarz, R P, Seager, S, Ségransan, D, Shporer, A, Simon, A E, Smith, A M S, Steller, M, Stockdale, C, Szabó, Gy M, Thomas, N, Torres, G, Tronsgaard, R, Udry, S, Ulmer, B, Van Grootel, V, Vanderspek, R, Venturini, J, Walton, N A, Winn, J N, Wohler, B, University of St Andrews. School of Physics and Astronomy, and University of St Andrews. St Andrews Centre for Exoplanet Science

Subjects
MCP, DAS
Abstract

We report the discovery of two warm sub-Neptunes transiting the bright (G = 9.5 mag) K-dwarf HD 15906 (TOI 461, TIC 4646810). This star was observed by the Transiting Exoplanet Survey Satellite (TESS) in sectors 4 and 31, revealing two small transiting planets. The inner planet, HD 15906 b, was detected with an unambiguous period but the outer planet, HD 15906 c, showed only two transits separated by ∼ 734 d, leading to 36 possible values of its period. We performed follow-up observations with the CHaracterising ExOPlanet Satellite (CHEOPS) to confirm the true period of HD 15906 c and improve the radius precision of the two planets. From TESS, CHEOPS, and additional ground-based photometry, we find that HD 15906 b has a radius of 2.24 ± 0.08 R⊕ and a period of 10.924709 ± 0.000032 d, whilst HD 15906 c has a radius of 2.93$^{+0.07}_{-0.06}$ R⊕ and a period of 21.583298$^{+0.000052}_{-0.000055}$ d. Assuming zero bond albedo and full day-night heat redistribution, the inner and outer planet have equilibrium temperatures of 668 ± 13 K and 532 ± 10 K, respectively. The HD 15906 system has become one of only six multiplanet systems with two warm (≲ 700 K) sub-Neptune sized planets transiting a bright star (G ≤ 10 mag). It is an excellent target for detailed characterization studies to constrain the composition of sub-Neptune planets and test theories of planet formation and evolution. Publisher PDF

Published
2023

42. Evolution of minimally invasive techniques and surgical outcomes of ALPPS in Italy: a comprehensive trend analysis over 10 years from a national prospective registry

Author

Serenari M., Ratti F., Guglielmo N., Zanello M., Mocchegiani F., Lenzi J., Colledan M., Mazzaferro V., Cillo U., Ferrero A., Cescon M., Di Benedetto F., Massani M., Grazi G., Valle R. D., Vivarelli M., Ettorre G. M., Aldrighetti L., Jovine E., Serenari, M, Ratti, F, Guglielmo, N, Zanello, M, Mocchegiani, F, Lenzi, J, Colledan, M, Mazzaferro, V, Cillo, U, Ferrero, A, Cescon, M, Di Benedetto, F, Massani, M, Grazi, G, Valle, R, Vivarelli, M, Ettorre, G, Aldrighetti, L, and Jovine, E

Subjects
Hepatectomy, Laparoscopy, ALPPS, Minimally invasive, Outcome
Abstract

Background: Since 2012, Associating Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS) has encountered several modifications of its original technique. The primary endpoint of this study was to analyze the trend of ALPPS in Italy over a 10-year period. The secondary endpoint was to evaluate factors affecting the risk of morbidity/mortality/post-hepatectomy liver failure (PHLF). Methods: Data of patients submitted to ALPPS between 2012 and 2021 were identified from the ALPPS Italian Registry and evaluation of time trends was performed. Results: From 2012 to 2021, a total of 268 ALPPS were performed within 17 centers. The number of ALPPS divided by the total number of liver resections performed by each center slightly declined (APC = -2.0%, p = 0.111). Minimally invasive (MI) approach significantly increased over the years (APC = + 49.5%, p = 0.002). According to multivariable analysis, MI completion of stage 1 was protective against 90-day mortality (OR = 0.05, p = 0.040) as well as enrollment within high-volume centers for liver surgery (OR = 0.32, p = 0.009). Use of interstage hepatobiliary scintigraphy (HBS) and biliary tumors were independent predictors of PHLF. Conclusions: This national study showed that use of ALPPS only slightly declined over the years with an increased use of MI techniques, leading to lower 90-day mortality. PHLF still remains an open issue.

Published
2023

43. Is minimally invasive liver surgery a reasonable option in recurrent HCC? A snapshot from the I Go MILS registry

Author

Levi Sandri, G, Colasanti, M, Aldrighetti, L, Guglielmi, A, Cillo, U, Mazzaferro, V, Dalla Valle, R, De Carlis, L, Salvatore, G, Di Benedetto, F, Ferrero, A, Ettorre, G, Antonucci, A, Batignani, G, Belli, G, Belli, A, Berti, S, Boggi, U, Bonsignore, P, Brolese, A, Calise, F, Ceccarelli, G, Cecconi, S, Colledan, M, Coratti, A, Ercolani, G, Ferla, F, Filauro, M, Floridi, A, Frena, A, Giuliani, A, Giuliante, F, Grazi, G, Gringeri, E, Griseri, G, Guerriero, S, Jovine, E, Magistri, P, Maida, P, Massani, M, Mezzatesta, P, Morelli, L, Russolillo, N, Navarra, G, Parisi, A, Patriti, A, Ravaioli, M, Ratti, F, Romito, R, Reggiani, P, Ruzzenente, A, Santambrogio, R, Berardi, G, Sgroi, G, Slim, A, Spada, M, Sposito, C, Tedeschi, U, Tisone, G, Torzilli, G, Veneroni, L, Vincenti, L, Zamboni, F, Zimmitti, G, Levi Sandri G. B., Colasanti M., Aldrighetti L., Guglielmi A., Cillo U., Mazzaferro V., Dalla Valle R., De Carlis L., Salvatore G., Di Benedetto F., Ferrero A., Ettorre G. M., Antonucci A., Batignani G., Belli G., Belli A., Berti S., Boggi U., Bonsignore P., Brolese A., Calise F., Ceccarelli G., Cecconi S., Colledan M., Coratti A., Ercolani G., Ferla F., Filauro M., Floridi A., Frena A., Giuliani A., Giuliante F., Grazi G. L., Gringeri E., Griseri G., Guerriero S., Jovine E., Magistri P., Maida P., Massani M., Mezzatesta P., Morelli L., Russolillo N., Navarra G., Parisi A., Patriti A., Ravaioli M., Ratti F., Romito R., Reggiani P., Ruzzenente A., Santambrogio R., Berardi G., Sgroi G., Slim A., Spada M., Sposito C., Tedeschi U., Tisone G., Torzilli G., Veneroni L., Vincenti L., Zamboni F., Zimmitti G., Levi Sandri, G, Colasanti, M, Aldrighetti, L, Guglielmi, A, Cillo, U, Mazzaferro, V, Dalla Valle, R, De Carlis, L, Salvatore, G, Di Benedetto, F, Ferrero, A, Ettorre, G, Antonucci, A, Batignani, G, Belli, G, Belli, A, Berti, S, Boggi, U, Bonsignore, P, Brolese, A, Calise, F, Ceccarelli, G, Cecconi, S, Colledan, M, Coratti, A, Ercolani, G, Ferla, F, Filauro, M, Floridi, A, Frena, A, Giuliani, A, Giuliante, F, Grazi, G, Gringeri, E, Griseri, G, Guerriero, S, Jovine, E, Magistri, P, Maida, P, Massani, M, Mezzatesta, P, Morelli, L, Russolillo, N, Navarra, G, Parisi, A, Patriti, A, Ravaioli, M, Ratti, F, Romito, R, Reggiani, P, Ruzzenente, A, Santambrogio, R, Berardi, G, Sgroi, G, Slim, A, Spada, M, Sposito, C, Tedeschi, U, Tisone, G, Torzilli, G, Veneroni, L, Vincenti, L, Zamboni, F, Zimmitti, G, Levi Sandri G. B., Colasanti M., Aldrighetti L., Guglielmi A., Cillo U., Mazzaferro V., Dalla Valle R., De Carlis L., Salvatore G., Di Benedetto F., Ferrero A., Ettorre G. M., Antonucci A., Batignani G., Belli G., Belli A., Berti S., Boggi U., Bonsignore P., Brolese A., Calise F., Ceccarelli G., Cecconi S., Colledan M., Coratti A., Ercolani G., Ferla F., Filauro M., Floridi A., Frena A., Giuliani A., Giuliante F., Grazi G. L., Gringeri E., Griseri G., Guerriero S., Jovine E., Magistri P., Maida P., Massani M., Mezzatesta P., Morelli L., Russolillo N., Navarra G., Parisi A., Patriti A., Ravaioli M., Ratti F., Romito R., Reggiani P., Ruzzenente A., Santambrogio R., Berardi G., Sgroi G., Slim A., Spada M., Sposito C., Tedeschi U., Tisone G., Torzilli G., Veneroni L., Vincenti L., Zamboni F., and Zimmitti G.

Abstract

Laparoscopic liver resection (LLR) for Hepatocellular carcinoma (HCC) is a safe procedure. Repeat surgery is more often required, and the role of minimally invasive liver surgery (MILS) is not yet clearly defined. The present study analyzes data compiled by the Italian Group of Minimally Invasive Liver Surgery (IGoMILS) on LLR. To compare repeated LLR with the first LLR for HCC is the primary endpoint. The secondary endpoint was to evaluate the outcome of repeat LLR in the case of primary open versus primary MILS surgery. The data cohort is divided into two groups. Group 1: first liver resection and Group 2: Repeat LLR. To compare the two groups a 3:1 Propensity Score Matching is performed to analyze open versus MILS primary resection. Fifty-two centers were involved in the present study, and 1054 patients were enrolled. 80 patients underwent to a repeat LLR. The type of resection was different, with more major resections in the group 1 before matching the two groups. After propensity score matching 3:1, each group consisted of 222 and 74 patients. No difference between the two groups was observed. In the subgroup analysis, in 44 patients the first resection was performed by an open approach. The other 36 patients were resected with a MILS approach. We found no difference between these two subgroups of patients. The present study in repeat MILS for HCC using the IGoMILS Registry has observed the feasibility and safety of the MILS procedure.

Published
2022

44. The largest western experience on salvage hepatectomy for recurrent hepatocellular carcinoma: propensity score-matched analysis on behalf of He.RC.O.Le.Study Group

Author

Iaria, M, Bianchi, G, Fazio, F, Ardito, F, Perri, P, Pontarolo, N, Conci, S, Donadon, M, Zanello, M, Lai, Q, Famularo, S, Molfino, S, Sciannamea, I, Fumagalli, L, Germani, P, Floridi, A, Ferrari, C, Zimmitti, G, Troci, A, Zago, M, Ferraro, V, Cipriani, F, Patauner, S, La Barba, G, Romano, M, Zanus, G, Ercolani, G, Frena, A, Aldrighetti, L, Memeo, R, Pinotti, E, Crespi, M, Hilal, M, Griseri, G, Tarchi, P, Chiarelli, M, Antonucci, A, Baiocchi, G, Romano, F, Rossi, M, Jovine, E, Torzilli, G, Ruzzenente, A, Maestri, M, Grazi, G, Giuliante, F, Ferrero, A, Dalla Valle, R, Giuffrida, M, Russolillo, N, Razionale, F, De Peppo, V, Tomasoni, M, Marchitelli, I, Costa, G, Laureiro, Z, Scotti, M, Calcagno, P, Cosola, D, Franceschi, A, Manzoni, A, Pennacchi, L, Montuori, M, Conticchio, M, Ratti, F, Notte, F, Cucchetti, A, Salvador, L, Corleone, P, Garancini, M, Ciulli, C, Iaria M., Bianchi G., Fazio F., Ardito F., Perri P., Pontarolo N., Conci S., Donadon M., Zanello M., Lai Q., Famularo S., Molfino S., Sciannamea I., Fumagalli L., Germani P., Floridi A., Ferrari C., Zimmitti G., Troci A., Zago M., Ferraro V., Cipriani F., Patauner S., La Barba G., Romano M., Zanus G., Ercolani G., Frena A., Aldrighetti L., Memeo R., Pinotti E., Crespi M., Hilal M. A., Griseri G., Tarchi P., Chiarelli M., Antonucci A., Baiocchi G. L., Romano F., Rossi M., Jovine E., Torzilli G., Ruzzenente A., Maestri M., Grazi G. L., Giuliante F., Ferrero A., Dalla Valle R., Giuffrida M., Russolillo N., Razionale F., De Peppo V., Tomasoni M., Marchitelli I., Costa G., Laureiro Z. L., Scotti M., Calcagno P., Cosola D., Franceschi A., Manzoni A., Pennacchi L., Montuori M., Conticchio M., Ratti F., Notte F., Cucchetti A., Salvador L., Corleone P., Garancini M., Ciulli C., Iaria, M, Bianchi, G, Fazio, F, Ardito, F, Perri, P, Pontarolo, N, Conci, S, Donadon, M, Zanello, M, Lai, Q, Famularo, S, Molfino, S, Sciannamea, I, Fumagalli, L, Germani, P, Floridi, A, Ferrari, C, Zimmitti, G, Troci, A, Zago, M, Ferraro, V, Cipriani, F, Patauner, S, La Barba, G, Romano, M, Zanus, G, Ercolani, G, Frena, A, Aldrighetti, L, Memeo, R, Pinotti, E, Crespi, M, Hilal, M, Griseri, G, Tarchi, P, Chiarelli, M, Antonucci, A, Baiocchi, G, Romano, F, Rossi, M, Jovine, E, Torzilli, G, Ruzzenente, A, Maestri, M, Grazi, G, Giuliante, F, Ferrero, A, Dalla Valle, R, Giuffrida, M, Russolillo, N, Razionale, F, De Peppo, V, Tomasoni, M, Marchitelli, I, Costa, G, Laureiro, Z, Scotti, M, Calcagno, P, Cosola, D, Franceschi, A, Manzoni, A, Pennacchi, L, Montuori, M, Conticchio, M, Ratti, F, Notte, F, Cucchetti, A, Salvador, L, Corleone, P, Garancini, M, Ciulli, C, Iaria M., Bianchi G., Fazio F., Ardito F., Perri P., Pontarolo N., Conci S., Donadon M., Zanello M., Lai Q., Famularo S., Molfino S., Sciannamea I., Fumagalli L., Germani P., Floridi A., Ferrari C., Zimmitti G., Troci A., Zago M., Ferraro V., Cipriani F., Patauner S., La Barba G., Romano M., Zanus G., Ercolani G., Frena A., Aldrighetti L., Memeo R., Pinotti E., Crespi M., Hilal M. A., Griseri G., Tarchi P., Chiarelli M., Antonucci A., Baiocchi G. L., Romano F., Rossi M., Jovine E., Torzilli G., Ruzzenente A., Maestri M., Grazi G. L., Giuliante F., Ferrero A., Dalla Valle R., Giuffrida M., Russolillo N., Razionale F., De Peppo V., Tomasoni M., Marchitelli I., Costa G., Laureiro Z. L., Scotti M., Calcagno P., Cosola D., Franceschi A., Manzoni A., Pennacchi L., Montuori M., Conticchio M., Ratti F., Notte F., Cucchetti A., Salvador L., Corleone P., Garancini M., and Ciulli C.

Abstract

Background: We aimed to evaluate, in a large Western cohort, perioperative and long-term oncological outcomes of salvage hepatectomy (SH) for recurrent hepatocellular carcinoma (rHCC) after primary hepatectomy (PH) or locoregional treatments. Methods: Data were collected from the Hepatocarcinoma Recurrence on the Liver Study Group (He.RC.O.Le.S.) Italian Registry. After 1:1 propensity score-matched analysis (PSM), two groups were compared: the PH group (patients submitted to resection for a first HCC) and the SH group (patients resected for intrahepatic rHCC after previous HCC-related treatments). Results: 2689 patients were enrolled. PH included 2339 patients, SH 350. After PSM, 263 patients were selected in each group with major resected nodule median size, intraoperative blood loss and minimally invasive approach significantly lower in the SH group. Long-term outcomes were compared, with no difference in OS and DFS. Univariate and multivariate analyses revealed only microvascular invasion as an independent prognostic factor for OS. Conclusion: SH proved to be equivalent to PH in terms of safety, feasibility and long-term outcomes, consistent with data gathered from East Asia. In the awaiting of reliable treatment-allocating algorithms for rHCC, SH appears to be a suitable alternative in patients fit for surgery, regardless of the previous therapeutic modality implemented.

Published
2022

45. Correction to: Is minimally invasive liver surgery a reasonable option in recurrent HCC? A snapshot from the I Go MILS registry (Updates in Surgery, (2021), 10.1007/s13304-021-01161-w)

Author

Levi Sandri G. B., Levi Sandri, G, Colasanti, M, Aldrighetti, L, Guglielmi, A, Cillo, U, Mazzaferro, V, Dalla Valle, R, De Carlis, L, Gruttadauria, S, Di Benedetto, F, Ferrero, A, Ettorre, G, Antonucci, A, Batignani, G, Belli, G, Belli, A, Berti, S, Boggi, U, Bonsignore, P, Brolese, A, Calise, F, Ceccarelli, G, Cecconi, S, Colledan, M, Coratti, A, Ercolani, G, Ferla, F, Filauro, M, Floridi, A, Frena, A, Giuliani, A, Giuliante, F, Grazi, G, Gringeri, E, Griseri, G, Guerriero, S, Jovine, E, Magistri, P, Maida, P, Massani, M, Mezzatesta, P, Morelli, L, Russolillo, N, Navarra, G, Parisi, A, Patriti, A, Ravaioli, M, Ratti, F, Romito, R, Reggiani, P, Ruzzenente, A, Santambrogio, R, Berardi, G, Sgroi, G, Slim, A, Spada, M, Sposito, C, Tedeschi, U, Tisone, G, Torzilli, G, Veneroni, L, Vincenti, L, Zamboni, F, Zimmitti, G, Levi Sandri G. B., Colasanti M., Aldrighetti L., Guglielmi A., Cillo U., Mazzaferro V., Dalla Valle R., De Carlis L., Gruttadauria S., Di Benedetto F., Ferrero A., Ettorre G. M., Antonucci A., Batignani G., Belli G., Belli A., Berti S., Boggi U., Bonsignore P., Brolese A., Calise F., Ceccarelli G., Cecconi S., Colledan M., Coratti A., Ercolani G., Ferla F., Filauro M., Floridi A., Frena A., Giuliani A., Giuliante F., Grazi G. L., Gringeri E., Griseri G., Guerriero S., Jovine E., Magistri P., Maida P., Massani M., Mezzatesta P., Morelli L., Russolillo N., Navarra G., Parisi A., Patriti A., Ravaioli M., Ratti F., Romito R., Reggiani P., Ruzzenente A., Santambrogio R., Berardi G., Sgroi G., Slim A., Spada M., Sposito C., Tedeschi U., Tisone G., Torzilli G., Veneroni L., Vincenti L., Zamboni F., Zimmitti G., Levi Sandri G. B., Levi Sandri, G, Colasanti, M, Aldrighetti, L, Guglielmi, A, Cillo, U, Mazzaferro, V, Dalla Valle, R, De Carlis, L, Gruttadauria, S, Di Benedetto, F, Ferrero, A, Ettorre, G, Antonucci, A, Batignani, G, Belli, G, Belli, A, Berti, S, Boggi, U, Bonsignore, P, Brolese, A, Calise, F, Ceccarelli, G, Cecconi, S, Colledan, M, Coratti, A, Ercolani, G, Ferla, F, Filauro, M, Floridi, A, Frena, A, Giuliani, A, Giuliante, F, Grazi, G, Gringeri, E, Griseri, G, Guerriero, S, Jovine, E, Magistri, P, Maida, P, Massani, M, Mezzatesta, P, Morelli, L, Russolillo, N, Navarra, G, Parisi, A, Patriti, A, Ravaioli, M, Ratti, F, Romito, R, Reggiani, P, Ruzzenente, A, Santambrogio, R, Berardi, G, Sgroi, G, Slim, A, Spada, M, Sposito, C, Tedeschi, U, Tisone, G, Torzilli, G, Veneroni, L, Vincenti, L, Zamboni, F, Zimmitti, G, Levi Sandri G. B., Colasanti M., Aldrighetti L., Guglielmi A., Cillo U., Mazzaferro V., Dalla Valle R., De Carlis L., Gruttadauria S., Di Benedetto F., Ferrero A., Ettorre G. M., Antonucci A., Batignani G., Belli G., Belli A., Berti S., Boggi U., Bonsignore P., Brolese A., Calise F., Ceccarelli G., Cecconi S., Colledan M., Coratti A., Ercolani G., Ferla F., Filauro M., Floridi A., Frena A., Giuliani A., Giuliante F., Grazi G. L., Gringeri E., Griseri G., Guerriero S., Jovine E., Magistri P., Maida P., Massani M., Mezzatesta P., Morelli L., Russolillo N., Navarra G., Parisi A., Patriti A., Ravaioli M., Ratti F., Romito R., Reggiani P., Ruzzenente A., Santambrogio R., Berardi G., Sgroi G., Slim A., Spada M., Sposito C., Tedeschi U., Tisone G., Torzilli G., Veneroni L., Vincenti L., Zamboni F., and Zimmitti G.

Abstract

In the originally published article the co-author first name and last name was interchanged. The correct name is copied below Salvatore Gruttadauria The original article has been updated.

Published
2022

46. Variations in risk-adjusted outcomes following 4318 laparoscopic liver resections

Author

Cucchetti, A, Aldrighetti, L, Ratti, F, Ferrero, A, Guglielmi, A, Giuliante, F, Cillo, U, Mazzaferro, V, De Carlis, L, Ercolani, G, Ettorre, G, di Benedetto, F, Valle, R, Gruttadauria, S, Jovine, E, Boggi, U, Vincenti, L, Santambrogio, R, Giuliani, A, Torzilli, G, Zimmiti, G, Brolese, A, Belli, A, Ravaioli, M, Frena, A, Rossi, G, Grazi, G, Zamboni, F, Berti, S, Calise, F, Massani, M, Morelli, L, Filauro, M, Tisone, G, Coratti, A, Navarra, G, Romito, R, Ceccarelli, G, Belli, G, Griseri, G, Antonucci, A, Mezzatesta, P, Veneroni, L, Schiavo, M, Colledan, M, Parisi, A, Guerriero, S, Spada, M, Batignani, G, Sgroi, G, Floridi, P, Boni, L, Maida, P, Ribero, D, La Barba, G, Cucchetti A., Aldrighetti L., Ratti F., Ferrero A., Guglielmi A., Giuliante F., Cillo U., Mazzaferro V., De Carlis L., Ercolani G., Ettorre G. M., di Benedetto F., Valle R. D., Gruttadauria S., Jovine E., Boggi U., Vincenti L., Santambrogio R., Giuliani A., Torzilli G., Zimmiti G., Brolese A., Belli A., Ravaioli M., Frena A., Rossi G. E., Grazi G. L., Zamboni F., Berti S., Calise F., Massani M., Morelli L., Filauro M., Tisone G., Coratti A., Navarra G., Romito R., Ceccarelli G., Belli G., Griseri G., Antonucci A., Mezzatesta P., Veneroni L., Schiavo M., Colledan M., Parisi A., Guerriero S., Spada M., Batignani G., Sgroi G., Floridi P., Boni L., Maida P., Ribero D., La Barba G., Cucchetti, A, Aldrighetti, L, Ratti, F, Ferrero, A, Guglielmi, A, Giuliante, F, Cillo, U, Mazzaferro, V, De Carlis, L, Ercolani, G, Ettorre, G, di Benedetto, F, Valle, R, Gruttadauria, S, Jovine, E, Boggi, U, Vincenti, L, Santambrogio, R, Giuliani, A, Torzilli, G, Zimmiti, G, Brolese, A, Belli, A, Ravaioli, M, Frena, A, Rossi, G, Grazi, G, Zamboni, F, Berti, S, Calise, F, Massani, M, Morelli, L, Filauro, M, Tisone, G, Coratti, A, Navarra, G, Romito, R, Ceccarelli, G, Belli, G, Griseri, G, Antonucci, A, Mezzatesta, P, Veneroni, L, Schiavo, M, Colledan, M, Parisi, A, Guerriero, S, Spada, M, Batignani, G, Sgroi, G, Floridi, P, Boni, L, Maida, P, Ribero, D, La Barba, G, Cucchetti A., Aldrighetti L., Ratti F., Ferrero A., Guglielmi A., Giuliante F., Cillo U., Mazzaferro V., De Carlis L., Ercolani G., Ettorre G. M., di Benedetto F., Valle R. D., Gruttadauria S., Jovine E., Boggi U., Vincenti L., Santambrogio R., Giuliani A., Torzilli G., Zimmiti G., Brolese A., Belli A., Ravaioli M., Frena A., Rossi G. E., Grazi G. L., Zamboni F., Berti S., Calise F., Massani M., Morelli L., Filauro M., Tisone G., Coratti A., Navarra G., Romito R., Ceccarelli G., Belli G., Griseri G., Antonucci A., Mezzatesta P., Veneroni L., Schiavo M., Colledan M., Parisi A., Guerriero S., Spada M., Batignani G., Sgroi G., Floridi P., Boni L., Maida P., Ribero D., and La Barba G.

Abstract

Background/Purpose: Quality measures in surgery are important to establish appropriate levels of care and to develop improvement strategies. The purpose of this study was to provide risk-adjusted outcome measures after laparoscopic liver resection (LLR). Methods: Data from a prospective, multicenter database involving 4318 patients submitted to LLRs in 41 hospitals from an intention-to-treat approach (2014–2020) were used to analyze heterogeneity (I2) among centers and to develop a risk-adjustment model on outcome measures through multivariable mixed-effect models to account for confounding due to case-mix. Results: Involved hospitals operated on very different patients: the largest heterogeneity was observed for operating in the presence of previous abdominal surgery (I2:79.1%), in cirrhotic patients (I2:89.3%) suffering from hepatocellular carcinoma (I2:88.6%) or requiring associated intestinal resections (I2:82.8%) and in regard to technical complexity (I2 for the most complex LLRs: 84.1%). These aspects determined substantial or large heterogeneity in overall morbidity (I2:84.9%), in prolonged in-hospital stay (I2:86.9%) and in conversion rate (I2:73.4%). Major complication had medium heterogeneity (I2:46.5%). The heterogeneity of mortality was null. Risk-adjustment accounted for all of this variability and the final risk-standardized conversion rate was 8.9%, overall morbidity was 22.1%, major morbidity was 5.1% and prolonged in-hospital stay was 26.0%. There were no outliers among the 41 participating centers. An online tool was provided. Conclusions: A benchmark for LLRs including all eligible patients was provided, suggesting that surgeons can act accordingly in the interest of the patient, modifying their approach in relation to different indications and different experience, but finally providing the same quality of care.

Published
2022

47. Technical feasibility and short-term outcomes of laparoscopic isolated caudate lobe resection: an IgoMILS (Italian Group of Minimally Invasive Liver Surgery) registry-based study

Author

Ruzzenente, A, Ciangherotti, A, Aldrighetti, L, Ettorre, G, De Carlis, L, Ferrero, A, Dalla Valle, R, Tisone, G, Guglielmi, A, Ratti, F, Gringeri, E, Russolillo, N, Campagnaro, T, Conci, S, Sandri, G, Ardito, F, Boggi, U, Gruttadauria, S, Vigano, L, Di Benedetto, F, Rossi, G, Berti, S, Ceccarelli, G, Vincenti, L, Cillo, U, Giuliante, F, Mazzaferro, V, Jovine, E, Calise, F, Belli, G, Zamboni, F, Coratti, A, Mezzatesta, P, Santambrogio, R, Navarra, G, Giuliani, A, Ferla, F, Pinna, A, Parisi, A, Colledan, M, Slim, A, Antonucci, A, Grazi, G, Frena, A, Sgroi, G, Brolese, A, Morelli, L, Floridi, A, Patriti, A, Veneroni, L, Boni, L, Maida, P, Griseri, G, Filauro, M, Guerriero, S, Romito, R, Tedeschi, U, Zimmitti, G, Ruzzenente A., Ciangherotti A., Aldrighetti L., Ettorre G. M., De Carlis L., Ferrero A., Dalla Valle R., Tisone G., Guglielmi A., Ratti F., Gringeri E., Russolillo N., Campagnaro T., Conci S., Sandri G. B. L., Ardito F., Boggi U., Gruttadauria S., Vigano L., Di Benedetto F., Rossi G. E., Berti S., Ceccarelli G., Vincenti L., Cillo U., Giuliante F., Mazzaferro V., Jovine E., Calise F., Belli G., Zamboni F., Coratti A., Mezzatesta P., Santambrogio R., Navarra G., Giuliani A., Ferla F., Pinna A. D., Parisi A., Colledan M., Slim A., Antonucci A., Grazi G. L., Frena A., Sgroi G., Brolese A., Morelli L., Floridi A., Patriti A., Veneroni L., Boni L., Maida P., Griseri G., Filauro M., Guerriero S., Romito R., Tedeschi U., Zimmitti G., Ruzzenente, A, Ciangherotti, A, Aldrighetti, L, Ettorre, G, De Carlis, L, Ferrero, A, Dalla Valle, R, Tisone, G, Guglielmi, A, Ratti, F, Gringeri, E, Russolillo, N, Campagnaro, T, Conci, S, Sandri, G, Ardito, F, Boggi, U, Gruttadauria, S, Vigano, L, Di Benedetto, F, Rossi, G, Berti, S, Ceccarelli, G, Vincenti, L, Cillo, U, Giuliante, F, Mazzaferro, V, Jovine, E, Calise, F, Belli, G, Zamboni, F, Coratti, A, Mezzatesta, P, Santambrogio, R, Navarra, G, Giuliani, A, Ferla, F, Pinna, A, Parisi, A, Colledan, M, Slim, A, Antonucci, A, Grazi, G, Frena, A, Sgroi, G, Brolese, A, Morelli, L, Floridi, A, Patriti, A, Veneroni, L, Boni, L, Maida, P, Griseri, G, Filauro, M, Guerriero, S, Romito, R, Tedeschi, U, Zimmitti, G, Ruzzenente A., Ciangherotti A., Aldrighetti L., Ettorre G. M., De Carlis L., Ferrero A., Dalla Valle R., Tisone G., Guglielmi A., Ratti F., Gringeri E., Russolillo N., Campagnaro T., Conci S., Sandri G. B. L., Ardito F., Boggi U., Gruttadauria S., Vigano L., Di Benedetto F., Rossi G. E., Berti S., Ceccarelli G., Vincenti L., Cillo U., Giuliante F., Mazzaferro V., Jovine E., Calise F., Belli G., Zamboni F., Coratti A., Mezzatesta P., Santambrogio R., Navarra G., Giuliani A., Ferla F., Pinna A. D., Parisi A., Colledan M., Slim A., Antonucci A., Grazi G. L., Frena A., Sgroi G., Brolese A., Morelli L., Floridi A., Patriti A., Veneroni L., Boni L., Maida P., Griseri G., Filauro M., Guerriero S., Romito R., Tedeschi U., and Zimmitti G.

Abstract

Background: Although isolated caudate lobe (CL) liver resection is not a contraindication for minimally invasive liver surgery (MILS), feasibility and safety of the procedure are still poorly investigated. To address this gap, we evaluate data on the Italian prospective maintained database on laparoscopic liver surgery (IgoMILS) and compare outcomes between MILS and open group. Methods: Perioperative data of patients with malignancies, as colorectal liver metastases (CRLM), hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC), non-colorectal liver metastases (NCRLM) and benign liver disease, were retrospectively analyzed. A propensity score matching (PSM) analysis was performed to balance the potential selection bias for MILS and open group. Results: A total of 224 patients were included in the study, 47 and 177 patients underwent MILS and open isolated CL resection, respectively. The overall complication rate was comparable between the two groups; however, severe complication rate (Dindo–Clavien grade ≥ 3) was lower in the MILS group (0% versus 6.8%, P = ns). In-hospital mortality was 0% in both groups and mean hospital stay was significantly shorter in the MILS group (P = 0.01). After selection of 42 MILS and 43 open CL resections by PSM analysis, intraoperative and postoperative outcomes remained similar except for the hospital stay which was not significantly shorter in MILS group. Conclusions: This multi-institutional cohort study shows that MILS CL resection is feasible and safe. The surgical procedure can be technically demanding compared to open resection, whereas good perioperative outcomes can be achieved in highly selected patients.

Published
2022

49. TESS and CHEOPS discover two warm sub-Neptunes transiting the bright K-dwarf HD 15906

Author

Tuson, A, primary, Queloz, D, additional, Osborn, H P, additional, Wilson, T G, additional, Hooton, M J, additional, Beck, M, additional, Lendl, M, additional, Olofsson, G, additional, Fortier, A, additional, Bonfanti, A, additional, Brandeker, A, additional, Buchhave, L A, additional, Collier Cameron, A, additional, Ciardi, D R, additional, Collins, K A, additional, Gandolfi, D, additional, Garai, Z, additional, Giacalone, S, additional, Gomes da Silva, J, additional, Howell, S B, additional, Patel, J A, additional, Persson, C M, additional, Serrano, L M, additional, Sousa, S G, additional, Ulmer-Moll, S, additional, Vanderburg, A, additional, Ziegler, C, additional, Alibert, Y, additional, Alonso, R, additional, Anglada, G, additional, Bárczy, T, additional, Barrado Navascues, D, additional, Barros, S C C, additional, Baumjohann, W, additional, Beck, T, additional, Benz, W, additional, Billot, N, additional, Bonfils, X, additional, Borsato, L, additional, Broeg, C, additional, Cabrera, J, additional, Charnoz, S, additional, Conti, D M, additional, Csizmadia, Sz, additional, Cubillos, P E, additional, Davies, M B, additional, Deleuil, M, additional, Delrez, L, additional, Demangeon, O D S, additional, Demory, B-O, additional, Dragomir, D, additional, Dressing, C D, additional, Ehrenreich, D, additional, Erikson, A, additional, Essack, Z, additional, Farinato, J, additional, Fossati, L, additional, Fridlund, M, additional, Furlan, E, additional, Gill, H, additional, Gillon, M, additional, Gnilka, C L, additional, Gonzales, E, additional, Güdel, M, additional, Günther, M N, additional, Hoyer, S, additional, Isaak, K G, additional, Jenkins, J M, additional, Kiss, L L, additional, Laskar, J, additional, Latham, D W, additional, Law, N, additional, Lecavelier des Etangs, A, additional, Curto, G Lo, additional, Lovis, C, additional, Luque, R, additional, Magrin, D, additional, Mann, A W, additional, Maxted, P F L, additional, Mayor, M, additional, McDermott, S, additional, Mecina, M, additional, Mordasini, C, additional, Mortier, A, additional, Nascimbeni, V, additional, Ottensamer, R, additional, Pagano, I, additional, Pallé, E, additional, Peter, G, additional, Piotto, G, additional, Pollacco, D, additional, Pritchard, T, additional, Ragazzoni, R, additional, Rando, N, additional, Ratti, F, additional, Rauer, H, additional, Ribas, I, additional, Ricker, G R, additional, Rieder, M, additional, Santos, N C, additional, Savel, A B, additional, Scandariato, G, additional, Schwarz, R P, additional, Seager, S, additional, Ségransan, D, additional, Shporer, A, additional, Simon, A E, additional, Smith, A M S, additional, Steller, M, additional, Stockdale, C, additional, Szabó, Gy M, additional, Thomas, N, additional, Torres, G, additional, Tronsgaard, R, additional, Udry, S, additional, Ulmer, B, additional, Van Grootel, V, additional, Vanderspek, R, additional, Venturini, J, additional, Walton, N A, additional, Winn, J N, additional, and Wohler, B, additional

Published
2023
Full Text
View/download PDF

50. A new dynamical modeling of the WASP-47 system with CHEOPS observations

Author

Nascimbeni, V., primary, Borsato, L., additional, Zingales, T., additional, Piotto, G., additional, Pagano, I., additional, Beck, M., additional, Broeg, C., additional, Ehrenreich, D., additional, Hoyer, S., additional, Majidi, F. Z., additional, Granata, V., additional, Sousa, S. G., additional, Wilson, T. G., additional, Van Grootel, V., additional, Bonfanti, A., additional, Salmon, S., additional, Mustill, A. J., additional, Delrez, L., additional, Alibert, Y., additional, Alonso, R., additional, Anglada, G., additional, Bárczy, T., additional, Barrado, D., additional, Barros, S. C. C., additional, Baumjohann, W., additional, Beck, T., additional, Benz, W., additional, Bergomi, M., additional, Billot, N., additional, Bonfils, X., additional, Brandeker, A., additional, Cabrera, J., additional, Charnoz, S., additional, Collier Cameron, A., additional, Csizmadia, Sz., additional, Cubillos, P. E., additional, Davies, M. B., additional, Deleuil, M., additional, Deline, A., additional, Demangeon, O. D. S., additional, Demory, B.-O., additional, Erikson, A., additional, Fortier, A., additional, Fossati, L., additional, Fridlund, M., additional, Gandolfi, D., additional, Gillon, M., additional, Güdel, M., additional, Isaak, K. G., additional, Kiss, L. L., additional, Laskar, J., additional, Lecavelier des Etangs, A., additional, Lendl, M., additional, Lovis, C., additional, Luque, R., additional, Magrin, D., additional, Maxted, P. F. L., additional, Mordasini, C., additional, Olofsson, G., additional, Ottensamer, R., additional, Pallé, E., additional, Peter, G., additional, Piazza, D., additional, Pollacco, D., additional, Queloz, D., additional, Ragazzoni, R., additional, Rando, N., additional, Ratti, F., additional, Rauer, H., additional, Ribas, I., additional, Santos, N. C., additional, Scandariato, G., additional, Ségransan, D., additional, Simon, A. E., additional, Smith, A. M. S., additional, Steinberger, M., additional, Steller, M., additional, Szabó, Gy. M., additional, Thomas, N., additional, Udry, S., additional, Venturini, J., additional, Walton, N. A., additional, and Wolter, D., additional

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results