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The era of big data has witnessed an increasing availability of observational data from mobile and social networking, online advertising, web mining, healthcare, education, public policy, marketing campaigns, and so on, which facilitates the development of causal effect estimation. Although significant advances have been made to overcome the challenges in the academic area, such as missing counterfactual outcomes and selection bias, they only focus on source-specific and stationary observational data, which is unrealistic in most industrial applications. In this paper, we investigate a new industrial problem of causal effect estimation from incrementally available observational data and present three new evaluation criteria accordingly, including extensibility, adaptability, and accessibility. We propose a Continual Causal Effect Representation Learning method for estimating causal effects with observational data, which are incrementally available from non-stationary data distributions. Instead of having access to all seen observational data, our method only stores a limited subset of feature representations learned from previous data. Combining selective and balanced representation learning, feature representation distillation, and feature transformation, our method achieves the continual causal effect estimation for new data without compromising the estimation capability for original data. Extensive experiments demonstrate the significance of continual causal effect estimation and the effectiveness of our method., Comment: The 39th IEEE International Conference on Data Engineering (ICDE 2023). arXiv admin note: text overlap with arXiv:2301.01026

Estimating treatment effects from observational data provides insights about causality guiding many real-world applications such as different clinical study designs, which are the formulations of trials, experiments, and observational studies in medical, clinical, and other types of research. In this paper, we describe causal inference for application in a novel clinical design called basket trial that tests how well a new drug works in patients who have different types of cancer that all have the same mutation. We propose a multi-task adversarial learning (MTAL) method, which incorporates feature selection multi-task representation learning and adversarial learning to estimate potential outcomes across different tumor types for patients sharing the same genetic mutation but having different tumor types. In our paper, the basket trial is employed as an intuitive example to present this new causal inference setting. This new causal inference setting includes, but is not limited to basket trials. This setting has the same challenges as the traditional causal inference problem, i.e., missing counterfactual outcomes under different subgroups and treatment selection bias due to confounders. We present the practical advantages of our MTAL method for the analysis of synthetic basket trial data and evaluate the proposed estimator on two benchmarks, IHDP and News. The results demonstrate the superiority of our MTAL method over the competing state-of-the-art methods., Comment: Proceedings of Machine Learning Research (PMLR); Conference on Health, Inference, and Learning (CHIL) 2022

The foremost challenge to causal inference with real-world data is to handle the imbalance in the covariates with respect to different treatment options, caused by treatment selection bias. To address this issue, recent literature has explored domain-invariant representation learning based on different domain divergence metrics (e.g., Wasserstein distance, maximum mean discrepancy, position-dependent metric, and domain overlap). In this paper, we reveal the weaknesses of these strategies, i.e., they lead to the loss of predictive information when enforcing the domain invariance; and the treatment effect estimation performance is unstable, which heavily relies on the characteristics of the domain distributions and the choice of domain divergence metrics. Motivated by information theory, we propose to learn the Infomax and Domain-Independent Representations to solve the above puzzles. Our method utilizes the mutual information between the global feature representations and individual feature representations, and the mutual information between feature representations and treatment assignment predictions, in order to maximally capture the common predictive information for both treatment and control groups. Moreover, our method filters out the influence of instrumental and irrelevant variables, and thus it effectively increases the predictive ability of potential outcomes. Experimental results on both the synthetic and real-world datasets show that our method achieves state-of-the-art performance on causal effect inference. Moreover, our method exhibits reliable prediction performances when facing data with different characteristics of data distributions, complicated variable types, and severe covariate imbalance., Comment: SIAM International Conference on Data Mining (SDM22)

Treatment effect estimation from observational data is a critical research topic across many domains. The foremost challenge in treatment effect estimation is how to capture hidden confounders. Recently, the growing availability of networked observational data offers a new opportunity to deal with the issue of hidden confounders. Unlike networked data in traditional graph learning tasks, such as node classification and link detection, the networked data under the causal inference problem has its particularity, i.e., imbalanced network structure. In this paper, we propose a Graph Infomax Adversarial Learning (GIAL) model for treatment effect estimation, which makes full use of the network structure to capture more information by recognizing the imbalance in network structure. We evaluate the performance of our GIAL model on two benchmark datasets, and the results demonstrate superiority over the state-of-the-art methods., Comment: Proceedings of the 27th ACM SIGKDD Conference on Knowledge Discovery and Data Mining (KDD '21), August 14--18, 2021, Virtual Event, Singapore

The dramatically growing availability of observational data is being witnessed in various domains of science and technology, which facilitates the study of causal inference. However, estimating treatment effects from observational data is faced with two major challenges, missing counterfactual outcomes and treatment selection bias. Matching methods are among the most widely used and fundamental approaches to estimating treatment effects, but existing matching methods have poor performance when facing data with high dimensional and complicated variables. We propose a feature selection representation matching (FSRM) method based on deep representation learning and matching, which maps the original covariate space into a selective, nonlinear, and balanced representation space, and then conducts matching in the learned representation space. FSRM adopts deep feature selection to minimize the influence of irrelevant variables for estimating treatment effects and incorporates a regularizer based on the Wasserstein distance to learn balanced representations. We evaluate the performance of our FSRM method on three datasets, and the results demonstrate superiority over the state-of-the-art methods., Comment: Proceedings of the 29th ACM International Conference on Information and Knowledge Management (CIKM '20)