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11 results on '"Rastovic, Una"'

2. THU-320-YI The pan-cyclophilin inhibitor rencofilstat exhibits therapeutic anti-fibrotic effects in human relevant models of alcohol-related liver disease via extracellular matrix remodelling

Author

Rastovic, Una, primary, Campinoti, Sara, additional, Wei, Lai, additional, Almeida, Bruna, additional, Bozzano, Sergio, additional, Amiri, Ramin, additional, Harris, Nicola, additional, Ajayi, Omolola, additional, Koay, Tsin Shue, additional, Kerins, Caoimhe, additional, Kenny, Fiona, additional, Zamalloa, Ane, additional, Adofina, Lissette, additional, Miquel, Rosa, additional, Zen, Yoh, additional, Srinivasan, Parthi, additional, Menon, Krishna, additional, Heaton, Nigel, additional, Luni, Camilla, additional, Gentleman, Eileen, additional, Shaw, Tanya, additional, Ure, Daren, additional, Chokshi, Shilpa, additional, Urbani, Luca, additional, and Palma, Elena, additional

Published
2024
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3. Human Precision-Cut Liver Slices: A Potential Platform to Study Alcohol-Related Liver Disease

Author

Rastovic, Una, primary, Bozzano, Sergio Francesco, additional, Riva, Antonio, additional, Simoni-Nieves, Arturo, additional, Harris, Nicola, additional, Miquel, Rosa, additional, Lackner, Carolin, additional, Zen, Yoh, additional, Zamalloa, Ane, additional, Menon, Krishna, additional, Heaton, Nigel, additional, Chokshi, Shilpa, additional, and Palma, Elena, additional

Published
2023
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4. Cyclophilin inhibition exhibits preventive and curative antifibrotic effects via extracellular matrix remodelling

Author

Campinoti, Sara, primary, Rastovic, Una, additional, Wei, Lai, additional, Harris, Nicola, additional, Almeida, Bruna, additional, Ajayi, Omolola, additional, Kerins, Caoimhe, additional, Kenny, Fiona, additional, Phillips, Sandra, additional, Zamalloa, Ane, additional, Miquel, Rosa, additional, Zen, Yoh, additional, Menon, Krishna, additional, Gentleman, Eileen, additional, Shaw, Tanya, additional, Heaton, Nigel, additional, Ure, Daren, additional, Chokshi, Shilpa, additional, Urbani, Luca, additional, and Palma, Elena, additional

Published
2023
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5. Human Precision-Cut Liver Slices: A Potential Platform to Study Alcohol-Related Liver Disease.

Author

Rastovic, Una, Bozzano, Sergio Francesco, Riva, Antonio, Simoni-Nieves, Arturo, Harris, Nicola, Miquel, Rosa, Lackner, Carolin, Zen, Yoh, Zamalloa, Ane, Menon, Krishna, Heaton, Nigel, Chokshi, Shilpa, and Palma, Elena

Subjects
*ALCOHOL-induced disorders, *LIVER diseases, *DRUG discovery, *ADRENOLEUKODYSTROPHY, *LIVER, *ETHANOL, *LIPOPOLYSACCHARIDES
Abstract

Alcohol-related liver disease (ALD) encompasses a range of pathological conditions that are complex to study at the clinical and preclinical levels. Despite the global burden of ALD, there is a lack of effective treatments, and mortality is high. One of the reasons for the unsuccessful development of novel therapies is that experimental studies are hindered by the challenge of recapitulating this multifactorial disorder in vitro, including the contributions of hepatotoxicity, impaired lipid metabolism, fibrosis and inflammatory cytokine storm, which are critical drivers in the pathogenesis of ALD in patients and primary targets for drug development. Here, we present the unique characteristics of the culture of human precision-cut liver slices (PCLS) to replicate key disease processes in ALD. PCLS were prepared from human liver specimens and treated with ethanol alone or in combination with fatty acids and lipopolysaccharide (FA + LPS) for up to 5 days to induce hepatotoxic, inflammatory and fibrotic events associated with ALD. Alcohol insult induced hepatocyte death which was more pronounced with the addition of FA + LPS. This mixture showed a significant increase in the cytokines conventionally associated with the prototypical inflammatory response observed in severe ALD, and interestingly, alcohol alone exhibited a different effect. Profibrogenic activation was also observed in the slices and investigated in the context of slice preparation. These results support the versatility of this organotypic model to study different pathways involved in alcohol-induced liver damage and ALD progression and highlight the applicability of the PCLS for drug discovery, confirming their relevance as a bridge between preclinical and clinical studies. [ABSTRACT FROM AUTHOR]

Published
2024
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7. ISBRA Bulletin Vol 5 Issue 1 2023

Author

Riva, Antonio, Hio Lam Phoebe Tsou, Rastovic, Una, Winrich, Evan, Schneider, Victor J., Warner, Jeffrey, Wang, Yan, Palma, Elena, Perez, Maribel Rodriguez, Barey, Agostina, Salguero, Agustin, Marengo, Leonardo, Mujica, Victoria, Pautassi, Ricardo, Camarini, Rosana, and Sung-Gon Kim

Published
2023
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8. Cyclophilin inhibitor CRV431 as a potential therapy for alcohol-related liver disease

Author

Palma, Elena, primary, Campinoti, Sara, additional, Rastovic, Una, additional, Harris, Nicola, additional, Koay, Tsin Shue, additional, Ajayi, Lola, additional, Almeida, Bruna, additional, Phillips, Sandra, additional, Ure, Daren, additional, Preziosi, Melissa, additional, Yumol, Marjorie, additional, Miquel, Rosa, additional, Zen, Yoh, additional, Prachalias, Andreas, additional, Menon, Krishna, additional, Heaton, Nigel, additional, Urbani, Luca, additional, and Chokshi, Shilpa, additional

Published
2022
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9. Dynamic organotypic culture of primary liver cancer as a personalised immunocompetent drug screening platform for immuno-oncology

Author

Jagatia, Ravi, primary, Doornebal, Ewald, additional, Caciolli, Lorenzo, additional, Harris, Nicola, additional, Rastovic, Una, additional, Campinoti, Sara, additional, Preziosi, Melissa, additional, Yumol, Marjorie, additional, Miquel, Rosa, additional, Zen, Yoh, additional, Prachalias, Andreas, additional, Menon, Krishna, additional, Mantero, Sara, additional, Phillips, Sandra, additional, Heaton, Nigel, additional, Urbani, Luca, additional, Palma, Elena, additional, and Chokshi, Shilpa, additional

Published
2022
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10. Patient-Derived Precision Cut Tissue Slices from Primary Liver Cancer as a Suitable Platform for Preclinical Drug Testing

Author

Doornebal, Ewald Jan, primary, Jagatia, Ravi, additional, Rastovic, Una, additional, Harris, Nicola, additional, Martinez Lyons, Anabel, additional, Miquel, Rosa, additional, Zen, Yoh, additional, Zamalloa, Ane, additional, Malik, Farooq, additional, Prachalias, Andreas, additional, Menon, Krishna, additional, Boulter, Luke, additional, Eaton, Simon, additional, Heaton, Nigel, additional, Chokshi, Shilpa, additional, and Palma, Elena, additional

Published
2022
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