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Hemochromatosis or iron storage disease (ISD) refers to the excessive accumulation of iron within the liver, resulting in damage to hepatocytes due to excessive dietary iron intake or variations in iron metabolism. The disease is challenging to resolve and understanding its pathophysiology and natural history of affected birds is essential to developing an effective treatment plan. Diagnosis is reliant on hepatic biopsy using Prussian-blue staining, and the severity of the condition can be graded based on the number of affected hepatocytes per slide. Hematology, biochemistry, diagnostic imaging, and iron serum testing generally are inadequate to confirm the diagnosis but may assist in evaluating concurrent pathologies. Clinical management is dependent on the disease severity, and dietary review ensuring iron intake remains below 50 mg/kg of dry matter fed in susceptible species may be sufficient in mild cases. Severe ISD additionally requires treatment with iron chelators or serial phlebotomy, and control of concurrent conditions. Treatment of chronic cases can be challenging. A surveillance program was initiated in 2020 examining coelioscopic hepatic biopsies of the hornbills from Jurong Bird Park to evaluate case prevalence and severity in the collection. 20 species were sampled, comprising a total of 85 birds. 27.1% of birds had no evidence of ISD, 54.1% had mild (Grade 1-2) ISD, and 18.8% had severe (Grade 3-4) ISD with notable species differences in disease occurrence. This presentation reviews the management practices utilized at Jurong Bird Park, the outcomes of treatment and expected prognosis in a range of species. [ABSTRACT FROM AUTHOR]