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The study was designed to determine the ameliorative potential of quercetin and catechin against the toxicity induced by co-exposure to Mancozeb (MZ) and arsenic in Wistar rats. Sixty-adult male Wistar rats were randomly divided into 10 groups (n=6). Group I served as control and group II was exposed to MZ [800 mg/kg, PO (per OS)]. Groups III, IV, and V were given drinking water containing sodium arsenite at the rate of 10, 50, and 100 ppb, respectively, for 28 days. Groups VI, VII, and VIII were treated with sodium arsenite in drinking water at 10, 50, and 100 ppb, respectively, along with MZ (800 mg/kg) for 28 days. Groups IX and X were given drinking water mixed with sodium arsenite at 100 ppb, MZ at 800 mg/kg, and quercetin (50 mg/kg) and catechin (50 mg/kg), respectively. Co-exposure to the toxicants (MZ and arsenic) significantly (P

Background: The present study aimed to determine the impact of the toxicological interaction between mancozeb (MZ) and arsenic (As) on oxidative injury to the kidney and to compare the ameliorative potential of quercetin and catechin against the induced toxicity. Methods: Sixty adult male Wistar rats were randomly and equally divided into 10 groups (n=6). Group I served as control and group II was treated with MZ [800 mg kg−1 body weight (BW), orally (PO)]. Groups III, IV, and V were exposed to As at the rate of 10, 50, and 100 ppb, respectively, in drinking water continuously for 28 days. Groups VI, VII, and VIII were provided drinking water with As at 10, 50, and 100 ppb, respectively, together with MZ for 28 days. Groups IX and X were given As in drinking water at 100 ppb and MZ at 800 mg kg−1, BW PO along with quercetin (50 mg kg−1) and catechin (50 mg kg−1), respectively. Results: Significant (P

This study aimed to determine the potential of quercetin and Zingiber officinale (ZO) Roscoe extract to alleviate the renal damage induced by dimethoate (DM) and fluoride (F-) alone and by their combined exposure in rats. A total of 54 adult Wistar rats were randomly allocated to nine groups (n = 6). A sub-lethal dose of DM (1/10th of the median lethal dose) was administered by oral gavage alone and along with F- (4.5 ppm, three-fold the permissible limit) in their drinking water continuously for 28 days. Chromatographical analysis revealed the presence of quercetin, curcumin, and other phytochemicals with strong antioxidant properties in ZO-rhizome extract. Severe changes were observed in the levels of the renal biomarkers and histoarchitecture after co-administration of the toxicants, indicating greater kidney damage. The administration of ZO extract (300 mg/kg) along with either or both toxicants led to a significant restoration of the biochemical markers and renal antioxidant profile and histology.