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620 results on '"Rashid, Imran"'

8. An Ensemble Based Deep Learning Framework to Detect and Deceive XSS and SQL Injection Attacks

Author

Bin Shahid, Waleed, Aslam, Baber, Abbas, Haider, Afzal, Hammad, Rashid, Imran, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Nguyen, Ngoc Thanh, editor, Tran, Tien Khoa, editor, Tukayev, Ualsher, editor, Hong, Tzung-Pei, editor, Trawiński, Bogdan, editor, and Szczerbicki, Edward, editor

Published
2022
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20. Molecular Imaging in Ischemic Heart Disease

Author

Lavín Plaza, Begoña, Theodoulou, Iakovos, Rashid, Imran, Hajhosseiny, Reza, Phinikaridou, Alkystis, Botnar, Rene M., Lavín Plaza, Begoña, Theodoulou, Iakovos, Rashid, Imran, Hajhosseiny, Reza, Phinikaridou, Alkystis, and Botnar, Rene M.

Abstract

Depto. de Bioquímica y Biología Molecular, Fac. de Ciencias Químicas, TRUE, pub

Published
2024

21. Sustained Focal Vascular Inflammation Accelerates Atherosclerosis in Remote Arteries

Author

Lavín Plaza, Begoña, Phinikaridou, Alkystis, Andia, Marcelo E., Potter, Myles, Lorrio, Silvia, Rashid, Imran, Botnar, Rene M., Lavín Plaza, Begoña, Phinikaridou, Alkystis, Andia, Marcelo E., Potter, Myles, Lorrio, Silvia, Rashid, Imran, and Botnar, Rene M.

Abstract

OBJECTIVE: Evidence from preclinical and clinical studies has demonstrated that myocardial infarction promotes atherosclerosis progression. The impact of focal vascular inflammation on the progression and phenotype of remote atherosclerosis remains unknown. APPROACH AND RESULTS: We used a novel ApoE−/− knockout mouse model of sustained arterial inflammation, initiated by mechanical injury in the abdominal aorta. Using serial in vivo molecular MRI and ex vivo histology and flow cytometry, we demonstrate that focal arterial inflammation triggered by aortic injury, accelerates atherosclerosis in the remote brachiocephalic artery. The brachiocephalic artery atheroma had distinct histological features including increased plaque size, plaque permeability, necrotic core to collagen ratio, infiltration of more inflammatory monocyte subsets, and reduced collagen content. We also found that arterial inflammation following focal vascular injury evoked a prolonged systemic inflammatory response manifested as a persistent increase in serum IL-6 (interleukin 6). Finally, we demonstrate that 2 therapeutic interventions—pravastatin and minocycline—had distinct anti-inflammatory effects at the plaque and systemic level. CONCLUSIONS: We show for the first time that focal arterial inflammation in response to vascular injury enhances systemic vascular inflammation, accelerates remote atheroma progression and induces plaques more inflamed, lipid-rich, and collagenpoor in the absence of ischemic myocardial injury. This inflammatory cascade is modulated by pravastatin and minocycline treatments, which have anti-inflammatory effects at both plaque and systemic levels that mitigate atheroma progression., Engineering and Physical Sciences Research Council (EPSRC), British Heart Foundation (BHF), King’s BHF Centre for Research Excellence, EPSRC Centre for Medical Engineering, Depto. de Bioquímica y Biología Molecular, Fac. de Ciencias Químicas, TRUE, pub

Published
2024

22. Tropoelastin: an in vivo imaging marker of dysfunctional matrix turnover during abdominal aortic dilation

Author

Lavín Plaza, Begoña, Lacerda, Sara, Andia, Marcelo E., Lorrio, Silvia, Bakewell, Robert, Smith, Alberto, Rashid, Imran, Botnar, René M., Phinikaridou, Alkystis, Lavín Plaza, Begoña, Lacerda, Sara, Andia, Marcelo E., Lorrio, Silvia, Bakewell, Robert, Smith, Alberto, Rashid, Imran, Botnar, René M., and Phinikaridou, Alkystis

Abstract

Aims Dysfunctional matrix turnover is present at sites of abdominal aortic aneurysm (AAA) and leads to the accumulation of monomeric tropoelastin rather than cross-linked elastin. We used a gadolinium-based tropoelastin-specific magnetic resonance contrast agent (Gd-TESMA) to test whether quantifying regional tropoelastin turnover correlates with aortic expansion in a murine model. The binding of Gd-TESMA to excised human AAA was also assessed. Methods and results We utilized the angiotensin II (Ang II)-infused apolipoprotein E gene knockout (ApoE−/−) murine model of aortic dilation and performed in vivo imaging of tropoelastin by administering Gd-TESMA followed by late gadolinium enhancement (LGE) magnetic resonance imaging (MRI) and T1 mapping at 3 T, with subsequent ex vivo validation. In a cross-sectional study (n = 66; control = 11, infused = 55) we found that Gd-TESMA enhanced MRI was elevated and confined to dilated aortic segments (control: LGE=0.13 ± 0.04 mm2, control R1= 1.1 ± 0.05 s−1 vs. dilated LGE =1.0 ± 0.4 mm2, dilated R1 =2.4 ± 0.9 s−1) and was greater in segments with medium (8.0 ± 3.8 mm3) and large (10.4 ± 4.1 mm3) compared to small (3.6 ± 2.1 mm3) vessel volume. Furthermore, a proof-of-principle longitudinal study (n = 19) using Gd-TESMA enhanced MRI demonstrated a greater proportion of tropoelastin: elastin expression in dilating compared to non-dilating aortas, which correlated with the rate of aortic expansion. Treatment with pravastatin and aspirin (n = 10) did not reduce tropoelastin turnover (0.87 ± 0.3 mm2 vs. 1.0 ± 0.44 mm2) or aortic dilation (4.86 ± 2.44 mm3 vs. 4.0 ± 3.6 mm3). Importantly, Gd-TESMA-enhanced MRI identified accumulation of tropoelastin in excised human aneurysmal tissue (n = 4), which was confirmed histologically. Conclusion Tropoelastin MRI identifies dysfunctional matrix remodelling that is specifically expressed in regions of aortic aneurysm or dissection and correlates with the development and rate of aortic expansi, British Heart Foundation, Chilean Agency of Technology and Science, Centre for Medical Engineering, Depto. de Bioquímica y Biología Molecular, Fac. de Ciencias Químicas, TRUE, pub

Published
2024

31. Clinical comparison of sub-mm high-resolution non-contrast coronary CMR angiography against coronary CT angiography in patients with low-intermediate risk of coronary artery disease: a single center trial

Author

Hajhosseiny, Reza, Rashid, Imran, Bustin, Aurélien, Munoz, Camila, Cruz, Gastao, Nazir, Muhummad Sohaib, Grigoryan, Karine, Ismail, Tevfik F., Preston, Rebecca, Neji, Radhouene, Kunze, Karl, Razavi, Reza, Chiribiri, Amedeo, Masci, Pier Giorgio, Rajani, Ronak, Prieto, Claudia, and Botnar, René M.

Published
2021
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34. Deep image prior cine MR fingerprinting with B1+ spin history correction.

Author

Hamilton, Jesse I., da Cruz, Gastão Lima, Rashid, Imran, Walker, Jonathan, Rajagopalan, Sanjay, and Seiberlich, Nicole

Subjects
MAGNETIC resonance imaging, CARDIAC magnetic resonance imaging, BLOOD flow
Abstract

Purpose: To develop a deep image prior (DIP) reconstruction for B1+‐corrected 2D cine MR fingerprinting (MRF). Methods: The proposed method combines low‐rank (LR) modeling with a DIP to generate cardiac phase‐resolved parameter maps without motion correction, employing self‐supervised training to enforce consistency with undersampled spiral k‐space data. Two implementations were tested: one approach (DIP) for cine T1, T2, and M0 mapping, and a second approach (DIP with effective B1+ estimation [DIP‐B1]) that also generated an effective B1+ map to correct for errors due to RF transmit inhomogeneities, through‐plane motion, and blood flow. Cine MRF data were acquired in 14 healthy subjects and four reconstructions were compared: LR, low‐rank motion‐corrected (LRMC), DIP, and DIP‐B1. Results were compared to diastolic ECG‐triggered MRF, MOLLI, and T2‐prep bSSFP. Additionally, bright‐blood and dark‐blood images calculated from cine MRF maps were used to quantify ventricular function and compared to reference cine measurements. Results: DIP and DIP‐B1 outperformed other cine MRF reconstructions with improved noise suppression and delineation of high‐resolution details. Within‐segment variability in the myocardium (reported as the coefficient of variation for T1/T2) was lowest for DIP‐B1 (2.3/8.3%) followed by DIP (2.7/8.7%), LRMC (3.5/10.5%), and LR (15.3/39.6%). Spatial homogeneity improved with DIP‐B1 having the lowest intersegment variability (2.6/4.1%). The mean bias in ejection fraction was −1.1% compared to reference cine scans. Conclusion: A DIP reconstruction for 2D cine MRF enabled cardiac phase‐resolved mapping of T1, T2, M0, and the effective B1+ with improved noise suppression and precision compared to LR and LRMC. [ABSTRACT FROM AUTHOR]

Published
2024
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35. ImNN: Neural Networks for Predicting Volume of Forest Trees

Author

Jeelani, M. Iqbal, primary, Jeelani, Fehim, additional, Mir, Shakeel Ahmad, additional, Geelani, Syed Naseem, additional, Lone, Mushtaq Ahmad, additional, Pala, Nazir A., additional, Danish, Faizan, additional, Tabassum, Afshan, additional, Islam, Khalid Ul, additional, Rashid, Imran, additional, and Yeasin, Md, additional

Published
2023
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38. ImFoR: Non-Linear Height Diameter Models for Forestry

Author

Jeelani, M. Iqbal, primary, Jeelani, Fehim, additional, Mir, Shakeel Ahmad, additional, Geelani, Syed Naseem, additional, Lone, Mushtaq Ahmad, additional, Ali, Asif, additional, Tabassum, Afshan, additional, Islam, Khalid Ul, additional, Rashid, Imran, additional, and Yeasin, Md, additional

Published
2023
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43. MIMO multi-hop relay systems

Author

Rashid, Imran and So, Daniel

Subjects
621.382, MINO HARQ Relay Multi-hop
Abstract

Multiple Input Multiple Output (MIMO) systems use multiple transmit and receive antennas to achieve higher data rates by transmitting multiple independent data systems. Transmission errors can be reduced by using Hybrid Automatic Repeat request (HARQ) combining techniques with MIMO systems. In this thesis, the use of HARQ for MIMO multi-hop communication is studied. We propose two MIMO HARQ combining methods which are based on using pre-combiningonly and a joint pre and post combining techniques. In addition to conventional single-hop transmission, HARQ schemes for MIMO multi-hop relay systems are also investigated. A novel approach is proposed to deal with the parallel HARQ processes in MIMO relay scenario. An information theoretic throughput analysis is performed to evaluate the performance of the relay system by employing various transmission techniques for relay-destination link. Evaluation is carried out on the delay involved while employing the relay systems as compared to single hop systems. Simulation results show that the proposed system can enhance the overall throughput performance of MIMO single-hop and multi-hop relay systems. Considering the recent research interest in green radio and requirements of reduced energy consumption by the wireless networks, we evaluated the energy efficiency of existing and proposed MIMO HARQ techniques for sensor and cellular networks. The results show that the proposed scheme is more energy efficient compared to other schemes in single-hop as well as multi-hop scenarios.

Published
2011

48. Pivotal Protocol for Same-Day Discharge Using Cardiac Magnetic Resonance Pre-Procedural Planning for Left Atrial Appendage Closure

Author

Dallan, Luis Augusto Palma, primary, Yoon, Sung-Han, additional, Gabasha, Shayef, additional, Rana, Mohammad Atif, additional, Galo, Jason, additional, Feroze, Rafey, additional, Reed, Joseph, additional, Rajagopalan, Sanjay, additional, Rashid, Imran, additional, Al-Kindi, Sadeer, additional, and Filby, Steven J., additional

Published
2023
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