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This article examines the space-time fractional phi-four (PF) model which is an improvement of the Klein-Fock-Gordon (KFG) model that is relevant in quantum mechanics, transmission of ultra-short pulses in optical fibers, de Broglie wave duality, and compound particles in spinless relativistic systems. New solitary wave solutions of the fractional phi-four equation were found with the help of the Riccati-Bernoulli sub-ODE method together with the Bäcklund transformation. The conformable fractional derivative played the role of improving the modeling of the complex dynamical systems. The obtained solutions, which were illustrated by giving 2D, 3D MATLAB plots and contour illustrations, were s eful in nuclear, particle physics and fluid mechanics. Thus, the current work demonstrates the applicability of the proposed approach in handling the fractional order deviations and contributes to the investigation of the dynamic behavior of the PF model.

A new one-parameter unit model is developed and investigated. The new model is known as the unit moment exponential distribution. Some essential mathematical characteristics of the distribution are determined. The model parameter is estimated using five distinct estimation approaches, including maximum likelihood, Anderson Darling, Cramer-von Mises, Ordinary least squares, and weighted least squares. A detailed simulation study is used to evaluate the behavior of engendered estimators. Maximum likelihood approaches appear to be an effective estimation technique. A regression model based on a new distribution is also derived. The validity and applicability of the new distribution are evaluated using two datasets, one on the duration of renal dialysis and the other on pump failure. It is identified that the new model efficiently analyzes these considered datasets.

Background: End-Stage Renal Disease (ESRD) patients under maintenance hemodialysis are at higher risk for COVID-19 and severe outcomes. This study aimed to investigate the association between ESRD patients who underwent maintenance hemodialysis at 5th Azar and Sayad Shirazi Hospital in Golestan Province in 2019 and their risk of contracting and experiencing severe outcomes from COVID-19. Furthermore, this study aimed to provide insights into the epidemic status of COVID-19 in this specific population, contributing to better insight into the unique challenges faced by ESRD patients on hemodialysis during the pandemic. Methods: This retrospective descriptive cross-sectional study was performed on patients who underwent maintenance hemodialysis. The diagnosis was made based on diagnostic criteria and COVID-19 PCR test. Medical information of all participants was collected. Medical information including clinical, laboratory, and radiological data as well as morbidity and mortality were collected and analyzed by experts. Statistical analysis was performed using SPSS version 21. Normality was evaluated using Shapiro-Wilk test and comparison between groups was analyzed using student T-test and Mann-Whitney U tests (p 0.05). No significant difference was observed between the age and BMI of passed away and discharged patients. None of the laboratory parameters in the two groups of passed away and discharged patients with COVID-19 showed a significant difference (p> 0.05). Patients with COVID-19 who had a history of diabetes and hypertension, clinical symptoms, such as cough (p=0.049), weakness, and lethargy (p=0.05), indicated a significant difference in mortality compared to the group that was discharged (p

The upper limb plays a crucial role in daily life activities, self-care, work, leisure, and social activities. It enables a person to perform essential tasks, such as eating, drinking, writing and searching the environment, leading to increased cognition and intelligence in children. Various disorders in children (for instance, Erb palsy, cerebral palsy, hemiplegia, muscular dystrophy, neuropathy) and adults (such as stroke and central, and peripheral nerve damage) can affect the functioning of the upper limb. While mobility aids exist for individuals with lower limb disabilities, there is a lack of suitable technical solutions for those with upper limb disorders because of structural and joint complications. Minimum muscle strength, at level 3 or higher, is necessary for limb movement, and this strength can be affected by neurological and musculoskeletal disorders, resulting in a limited range of motion or no movement.

In this paper, the transport properties of a phosphorene nanoribbon with zigzag edges are investigated. Although phosphorene is a two-dimensional structure with gaps, each zigzag edge of phosphorene nanoribbon acts like a one-dimensional quantum wire, so a nanoribbon with two edges is similar to two parallel quantum wires. We also show that by adding an impurity line between the upper and lower edges, we can create an impurity strip that can connect the upper edge to the lower edge. In other words, different inputs can be coupled to different outputs. To calculate coupling coefficients between inputs and outputs, we use the Lippmann-Schwinger formulation. The final results show that depending on the energy of the input state and the corresponding standing wave in the impurity band, the phenomenon of resonance or anti-resonance can be created in the dispersion between inputs and outputs. Besides the theoretical aspect of the proposed scheme presented in this article, it can be applied to make nanoswitches in practice.

Mangosteen pericarp (MP) is abundant in bioactive compounds but is often discarded as waste, leading to environmental pollution. This study compared the extraction of dried MP using maceration and high-pressure processing (HPP). HPP at 10 min (500 MPa/20 °C) resulted in the highest ACNs, total phenolic content (TPC), total flavonoid content (TFC), and antioxidant activities. It also significantly reduced residual enzyme activities (REA) of polyphenol oxidase (PPO) and peroxidase (POD) by 33.90 % and 8.27 %, respectively. Fourier-transform infrared spectroscopy (FT-IR) analysis revealed a new wavelength at 2665.25 cm−1, and scanning electron microscopy (SEM) showed significant pore formation in MP cells, indicating cell damage. HPP-10 min enhanced the extraction of bioactive compounds, which significantly elevated the thermal stability of ACNs at 60 °C. This suggests that HPP is a promising method for extracting and preserving ACNs and other bioactive compounds from dried MP, with potential applications as natural colorants.

IntroductionGender dysphoria (GD) is associated with profound mental health challenges, including heightened suicide risk. This study aimed to explore the mental health status and attitudes toward suicide among individuals with GD in Iran.MethodsA comprehensive assessment was conducted using three validated tools: the General Health Questionnaire (GHQ-28) to gauge emotional distress and psychological well-being, the Beck Depression Inventory (BDI-II) to evaluate the severity of depressive symptoms, and the Predicament Questionnaire (PQ) to measure attitudes toward suicide in the context of social crises.ResultsAmong the 78 participants, 43 (55.1%) were identified as experiencing significant mental health issues, while 21 (26.9%) were found to suffer from severe depression. The average PQ score was 57.92, which aligns with findings from similar populations in previous studies, highlighting a concerning trend in suicide-related attitudes. Further statistical analysis revealed significant correlations between psychological distress (GHQ-28 scores) and attitudes toward suicide (PQ scores), as well as between depressive symptoms (BDI-II scores) and suicide-related attitudes.ConclusionsThese findings indicate a pervasive prevalence of psychological disorders, particularly depression, within this group, and underscore the strong association between depressive states and suicidal ideation. The study underscores the urgent need for targeted mental health interventions and comprehensive healthcare policies tailored to the specific needs of individuals with GD in Iran. Given the substantial mental health burden observed, particularly the risk of suicide, this research highlights the critical importance of integrating mental health care into broader support systems for this population.

Prostate-specific antigen (PSA) remains the cornerstone for prostate cancer diagnosis. This study presents a highly sensitive aptamer-based electrochemical biosensor for PSA detection utilizing a novel two-dimensional (2D):2D reduced graphene oxide (rGO)/graphitic carbon nitride (g-C3N4) composite decorated with gold nanoparticles (Au NPs). The aptamer chains were immobilized on a glassy carbon electrode (GCE) modified with the rGO/g-C3N4/Au NPs composite. The successful synthesis of the nanomaterial and electrode modification were confirmed using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and transmission electron microscopy (TEM). The electrochemical properties and selectivity of the modified GCE were characterized by cyclic voltammetry (CV), square wave voltammetry (SQW), and electrochemical impedance spectroscopy (EIS). The biosensor exhibited high selectivity towards PSA compared to potential interferents like carbohydrate antigen 15-3 (CA 15-3), bovine serum albumin (BSA), fetal bovine serum (FBS), and glucose (C6H12O6). Under optimized conditions, the biosensor achieved a rapid detection time of 30 min for PSA and a remarkable limit of detection (LOD) of 0.44 fM (femtomolar) using methylene blue (MB) as the redox mediator. The limit of quantification (LOQ) was also exceptionally low at 2.5 fM. The applicability of the developed biosensor was further validated by analyzing real serum samples, demonstrating its potential for clinical use.

5-Fluorouracil (5FU) is a common chemotherapy drug for various cancers. It has exhibited large potentials for the treatment of both malignant and premalignant tumors. In the meantime, topical application of 5FU has been limited to surface pre-carcinogenic tumors. So far, a number of nano systems have been developed for encapsulation and targeted delivery of 5FU to improve its solubility, bioavailability, and functional characteristics, leading to the development of, for example, 5FU carriers in topical treatments. Due to their considerable advantages over ordinary therapies, nanotechnology-based drug delivery systems (DDSs), particularly polymeric nanocarriers (PNCs), have led to some sorts of evolution in many fields, including disease diagnosis and DDS. As a naturally occurring polymer, chitosan (CS) has long been regarded because of its biodegradability, biocompatibility, polycationic nature, non-toxicity, and non-allergenic nature. In addition, the pH-responsive nature of CS provides an exact drug dispersion in the cancer environment, converting it a promising carrier system. Utilization of 5-FU into carbon nanocarriers has indicated positive results such as targeted delivery to tumors and prevention of cancer activity. Researchers have successfully synthesized a handful of CS nanocarriers with distinctive characteristics for targeted delivery of 5FU; these come in different forms, including nano-sized particles (NPs), composites (NCs), emulsions (NEs), and fibers (NFs). This study reviews the mechanism of CS in different formulations by analyzing the physicochemical characteristics of the corresponding DDS in terms of morphology, surface charge, release profile, and encapsulation driving force. A more detailed analysis was performed on the most popular pharmaceutical applications of 5FU-loaded CS NPs. Effective facilitation of targeted delivery of 5FU and improvement of its therapeutic effects for various cancers by the CS were also indicated. Herein, the readers are introduced to nanoscale systems based on natural polymers like chitosan as promising platforms for cancer diagnosis and therapy. More recent discoveries on mechanistic anticancer behavior of 5FU-loaded CS NPs was further discussed.

In recent years, antibacterial wound dressings have gained considerable attention. Bacterial cellulose (BC) has received significant interest due to its unique physiochemical characteristics such as biocompatibility, high porosity, superior mechanical properties, water holding capacity, and nontoxicity. In this work, silver nanoparticles/graphitic carbon nitride/eucalyptus extract (Ag/gCN/EE) nanocomposite was synthesized as an antibacterial agent and incorporated into nanofibrous structures composed of BC. The BC/Ag/gCN/EE and polyvinyl alcohol/BC/Ag/gCN/EE (PVA/BC/Ag/gCN/EE) nanocomposites were synthesized using immersion and electrospinning methods, respectively. Then, the swelling ratio was optimized and the wound dressings were prepared based on the optimal formulation. The release profile, biodegradability and mechanical properties of the wound dressings were assessed. The antibacterial property of Ag/gCN/EE was studied demonstrating strong antibacterial activity on E. coli and S. aureus. MTT assay was carried out on NIH 3T3 fibroblast cells, and BC/Ag/gCN/EE and PVA/BC/Ag/gCN/EE nanocomposites showed 89 ± 2.31 % and 96 ± 3.28 % viability, respectively and no toxicity. To assess the effect of the composites on in vitro wound healing and cell migration, scratch wound assay was performed. The results indicated that after 24 h, BC/Ag/gCN/EE and PVA/BC/Ag/gCN/EE reduced 18.69 and 23.97 % of the scratch area compared to the control group. The prepared composites are promising wound dressings that could accelerate wound healing and kill bacteria simultaneously.

Background and Objective: Sexual self-disclosure plays an important role in couples' sexual performance and satisfaction. It is necessary to have a valid, reliable tool to measure this variable. A review of the literature shows that there is no tool with socio-cultural appropriateness for Iranian women in this field. Therefore, the purpose of this research was to design and evaluate the psychometric properties of a context-based female sexual self-disclosure questionnaire. Materials and Methods: This methodological study was conducted in Tehran city in 2020. In the first phase, the sexual self-disclosure of Iranian women and its dimensions was explored by reviewing the literature using the thematic analysis approach. Then, using the deductive-inductive approach, the first 25 items were compiled. In the second phase, psychometric assessment was done by examining face, content, construct, and criterion validity, as well as internal consistency and test-retest reliability. Results: According to the results, sexual self-disclosure of Iranian women was extracted as "talking about sexual relationships and factors affecting quantity and quality." Quantitative indicators for content validity index and content validity ratio were 0.95 and 0.79, respectively. The results of examining the construct validity of the tool by exploratory factor analysis led to the identification of four factors that explained 65.06 of the variances. The assessment of the convergent validity indicated the correlation coefficients between the total score of this questionnaire and the Larson Sexual Satisfaction Questionnaire in the range of 0.66 to 0.93. Conclusion: The results showed that women’s sexual self-disclosure questionnaire had optimal validity and reliability. Therefore, it is suggested to use this instrument in future studies to assess the level of Iranian female's sexual self-disclosure.