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181 results on '"Rashbass, Jem"'

1. Learning Dynamic and Personalized Comorbidity Networks from Event Data using Deep Diffusion Processes

Author

Qian, Zhaozhi, Alaa, Ahmed M., Bellot, Alexis, Rashbass, Jem, and van der Schaar, Mihaela

Subjects
Computer Science - Machine Learning, Statistics - Machine Learning
Abstract

Comorbid diseases co-occur and progress via complex temporal patterns that vary among individuals. In electronic health records we can observe the different diseases a patient has, but can only infer the temporal relationship between each co-morbid condition. Learning such temporal patterns from event data is crucial for understanding disease pathology and predicting prognoses. To this end, we develop deep diffusion processes (DDP) to model "dynamic comorbidity networks", i.e., the temporal relationships between comorbid disease onsets expressed through a dynamic graph. A DDP comprises events modelled as a multi-dimensional point process, with an intensity function parameterized by the edges of a dynamic weighted graph. The graph structure is modulated by a neural network that maps patient history to edge weights, enabling rich temporal representations for disease trajectories. The DDP parameters decouple into clinically meaningful components, which enables serving the dual purpose of accurate risk prediction and intelligible representation of disease pathology. We illustrate these features in experiments using cancer registry data.

Published
2020

2. BRCA Challenge: BRCA Exchange as a global resource for variants in BRCA1 and BRCA2.

Author

Cline, Melissa S, Liao, Rachel G, Parsons, Michael T, Paten, Benedict, Alquaddoomi, Faisal, Antoniou, Antonis, Baxter, Samantha, Brody, Larry, Cook-Deegan, Robert, Coffin, Amy, Couch, Fergus J, Craft, Brian, Currie, Robert, Dlott, Chloe C, Dolman, Lena, den Dunnen, Johan T, Dyke, Stephanie OM, Domchek, Susan M, Easton, Douglas, Fischmann, Zachary, Foulkes, William D, Garber, Judy, Goldgar, David, Goldman, Mary J, Goodhand, Peter, Harrison, Steven, Haussler, David, Kato, Kazuto, Knoppers, Bartha, Markello, Charles, Nussbaum, Robert, Offit, Kenneth, Plon, Sharon E, Rashbass, Jem, Rehm, Heidi L, Robson, Mark, Rubinstein, Wendy S, Stoppa-Lyonnet, Dominique, Tavtigian, Sean, Thorogood, Adrian, Zhang, Can, Zimmermann, Marc, BRCA Challenge Authors, Burn, John, Chanock, Stephen, Rätsch, Gunnar, and Spurdle, Amanda B

Subjects
BRCA Challenge Authors, Humans, Breast Neoplasms, Ovarian Neoplasms, Genetic Predisposition to Disease, Risk Factors, Information Dissemination, Gene Frequency, Phenotype, Penetrance, Mutation, Alleles, Genes, BRCA1, Genes, BRCA2, Databases, Genetic, Female, Male, Genetic Variation, Breast Cancer, Cancer, Genetics, Human Genome, 2.6 Resources and infrastructure (aetiology), Developmental Biology
Abstract

The BRCA Challenge is a long-term data-sharing project initiated within the Global Alliance for Genomics and Health (GA4GH) to aggregate BRCA1 and BRCA2 data to support highly collaborative research activities. Its goal is to generate an informed and current understanding of the impact of genetic variation on cancer risk across the iconic cancer predisposition genes, BRCA1 and BRCA2. Initially, reported variants in BRCA1 and BRCA2 available from public databases were integrated into a single, newly created site, www.brcaexchange.org. The purpose of the BRCA Exchange is to provide the community with a reliable and easily accessible record of variants interpreted for a high-penetrance phenotype. More than 20,000 variants have been aggregated, three times the number found in the next-largest public database at the project's outset, of which approximately 7,250 have expert classifications. The data set is based on shared information from existing clinical databases-Breast Cancer Information Core (BIC), ClinVar, and the Leiden Open Variation Database (LOVD)-as well as population databases, all linked to a single point of access. The BRCA Challenge has brought together the existing international Evidence-based Network for the Interpretation of Germline Mutant Alleles (ENIGMA) consortium expert panel, along with expert clinicians, diagnosticians, researchers, and database providers, all with a common goal of advancing our understanding of BRCA1 and BRCA2 variation. Ongoing work includes direct contact with national centers with access to BRCA1 and BRCA2 diagnostic data to encourage data sharing, development of methods suitable for extraction of genetic variation at the level of individual laboratory reports, and engagement with participant communities to enable a more comprehensive understanding of the clinical significance of genetic variation in BRCA1 and BRCA2.

Published
2018

3. Impact of the COVID-19 pandemic on the detection and management of colorectal cancer in England: a population-based study

Author

Morris, Eva J A, Goldacre, Raphael, Spata, Enti, Mafham, Marion, Finan, Paul J, Shelton, Jon, Richards, Mike, Spencer, Katie, Emberson, Jonathan, Hollings, Sam, Curnow, Paula, Gair, Dominic, Sebag-Montefiore, David, Cunningham, Chris, Rutter, Matthew D, Nicholson, Brian D, Rashbass, Jem, Landray, Martin, Collins, Rory, Casadei, Barbara, and Baigent, Colin

Published
2021
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5. Identification of Patient Prescribing Predicting Cancer Diagnosis Using Boosted Decision Trees

Author

French, Josephine, Chen, Cong, Henson, Katherine, Shand, Brian, Ferris, Patrick, Pencheon, Josh, Vernon, Sally, Rafiq, Meena, Howe, David, Lyratzopoulos, Georgios, Rashbass, Jem, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Riaño, David, editor, Wilk, Szymon, editor, and ten Teije, Annette, editor

Published
2019
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6. Impact of variation in cancer registration practice on observed international cancer survival differences between International Cancer Benchmarking Partnership (ICBP) jurisdictions

Author

Eden, Michael, Harrison, Samantha, Griffin, Michelle, Lambe, Mats, Pettersson, David, Gavin, Anna, Brewster, David H., Lin, Yulan, Johannesen, Tom B., Milne, Roger L., Farrugia, Helen, Nishri, Diane, King, Mary-Jane, Huws, Dyfed W, Warlow, Janet, Turner, Donna, Earle, Craig C., Peake, Michael, and Rashbass, Jem

Published
2019
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7. Treatment challenges in and outside a network setting: Head and neck cancers

Author

Hackl, Monika, Eycken, Elizabeth Van, Henau, Kris, Dimitrova, Nadya, Sekerija, Mario, Dušek, Ladislav, Mägi, Margit, Malila, Nea, Leinonen, Maarit, Velten, Michel, Troussard, Xavier, Bouvier, Veronique, Guizard, Anne-Valérie, Bouvier, Anne-Marie, Arveux, Patrick, Maynadié, Marc, Woronoff, Anne-Sophie, Robaszkiewic, Michel, Baldi, Isabelle, Monnereau, Alain, Tretarre, Brigitte, Colonna, Marc, Molinié, Florence, Bara, Simona, Schvartz, Claire, Lapôtre-Ledoux, Bénédicte, Grosclaude, Pascale, Stabenow, Roland, Luttmann, Sabine, Nennecke, Alice, Engel, Jutta, Schubert-Fritschle, Gabriele, Heidrich, Jan, Holleczek, Bernd, Jónasson, Jón Gunnlaugur, Clough-Gorr, Kerri, Comber, Harry, Mazzoleni, Guido, Giacomin, Adriano, Sutera Sardo, Antonella, Barchielli, Alessandr, Serraino, Diego, De Angelis, Roberta, Mallone, Sandra, Tavilla, Andrea, Pierannunzio, Daniela, Rossi, Silvia, Santaquilani, Mariano, Knijn, Arnold, Pannozzo, Fabio, Gennaro, Valerio, Benfatto, Lucia, Ricci, Paolo, Autelitano, Mariangela, Spagnoli, Gianbattista, Fusco, Mario, Usala, Mario, Vitale, Francesco, Michiara, Maria, Tumino, Rosario, Mangone, Lucia, Falcini, Fabio, Ferretti, Stefano, Filiberti, Rosa Angela, Marani, Enza, Iannelli, Arturo, Sensi, Flavio, Piffer, Silvano, Gentilini, Maria, Madeddu, Anselmo, Ziino, Antonio, Maspero, Sergio, Candela, Pina, Stracci, Fabrizio, Tagliabue, Giovanna, Rugge, Massimo, Trama, Annalisa, Gatta, Gemma, Botta, Laura, Capocaccia, Riccardo, Pildava, Santa, Smailyte, Giedre, Calleja, Neville, Johannesen, Tom Børge, Rachtan, Jadwiga, Góźdź, Stanisław, Błaszczyk, Jerzy, Kępska, Kamila, de Lacerda, Gonçalo Forjaz, Bento, Maria José, Miranda, Ana, Diba, Chakameh Safaei, Almar, Enrique, Larrañaga, Nerea, de Munain, Arantza Lopez, Torrella-Ramos, Ana, Díaz García, José María, Marcos-Gragera, Rafael, Sanchez, Maria Josè, Navarro, Carmen, Salmeron, Diego, Moreno-Iribas, Conchi, Galceran, Jaume, Carulla, Marià, Mousavi, Mohsen, Bouchardy, Christine, Ess, Silvia M., Bordoni, Andrea, Konzelmann, Isabelle, Rashbass, Jem, Gavin, Anna, Brewster, David H., Huws, Dyfed Wyn, Visser, Otto, Bielska-Lasota, Magdalena, Primic-Zakelj, Maja, Kunkler, Ian, Benhamou, Ellen, Orlandi, Ester, Alfieri, Salvatore, Simon, Christian, and Licitra, Lisa

Published
2019
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8. Testicular germ-cell tumours and penile squamous cell carcinoma: Appropriate management makes the difference

Author

Hackl, Monika, Eycken, Elizabeth Van, Henau, Kris, Dimitrova, Nadya, Sekerija, Mario, Dušek, Ladislav, Mägi, Margit, Malila, Nea, Leinonen, Maarit, Velten, Michel, Troussard, Xavier, Bouvier, Veronique, Guizard, Anne-Valérie, Bouvier, Anne-Marie, Arveux, Patrick, Maynadié, Marc, Woronoff, Anne-Sophie, Robaszkiewic, Michel, Baldi, Isabelle, Monnereau, Alain, Tretarre, Brigitte, Colonna, Marc, Molinié, Florence, Bara, Simona, Schvartz, Claire, Lapôtre-Ledoux, Bénédicte, Grosclaude, Pascale, Stabenow, Roland, Luttmann, Sabine, Nennecke, Alice, Engel, Jutta, Schubert-Fritschle, Gabriele, Heidrich, Jan, Holleczek, Bernd, Jónasson, Jón Gunnlaugur, Clough-Gorr, Kerri, Comber, Harry, Mazzoleni, Guido, Giacomin, Adriano, Sutera Sardo, Antonella, Barchielli, Alessandr, Serraino, Diego, De Angelis, Roberta, Mallone, Sandra, Tavilla, Andrea, Pierannunzio, Daniela, Rossi, Silvia, Santaquilani, Mariano, Knijn, Arnold, Pannozzo, Fabio, Gennaro, Valerio, Benfatto, Lucia, Ricci, Paolo, Autelitano, Mariangela, Spagnoli, Gianbattista, Fusco, Mario, Usala, Mario, Vitale, Francesco, Michiara, Maria, Tumino, Rosario, Mangone, Lucia, Falcini, Fabio, Ferretti, Stefano, Filiberti, Rosa Angela, Marani, Enza, Iannelli, Arturo, Sensi, Flavio, Piffer, Silvano, Gentilini, Maria, Madeddu, Anselmo, Ziino, Antonio, Maspero, Sergio, Candela, Pina, Stracci, Fabrizio, Tagliabue, Giovanna, Rugge, Massimo, Trama, Annalisa, Gatta, Gemma, Botta, Laura, Capocaccia, Riccardo, Pildava, Santa, Smailyte, Giedre, Calleja, Neville, Johannesen, Tom Børge, Rachtan, Jadwiga, Góźdź, Stanisław, Błaszczyk, Jerzy, Kępska, Kamila, de Lacerda, Gonçalo Forjaz, Bento, Maria José, Miranda, Ana, Diba, Chakameh Safaei, Almar, Enrique, Larrañaga, Nerea, de Munain, Arantza Lopez, Torrella-Ramos, Ana, Díaz García, José María, Marcos-Gragera, Rafael, Sanchez, Maria Josè, Navarro, Carmen, Salmeron, Diego, Moreno-Iribas, Conchi, Galceran, Jaume, Carulla, Marià, Mousavi, Mohsen, Bouchardy, Christine, M. Ess, Silvia, Bordoni, Andrea, Konzelmann, Isabelle, Rashbass, Jem, Gavin, Anna, Brewster, David H., Huws, Dyfed Wyn, Visser, Otto, Bielska-Lasota, Magdalena, Primic-Zakelj, Maja, Kunkler, Ian, Benhamou, Ellen, Nicolai, Nicola, Biasoni, Davide, Catanzaro, Mario A., and Colecchia, Maurizio

Published
2019
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9. Mesothelioma and thymic tumors: Treatment challenges in (outside) a network setting

Author

Hackl, Monika, Eycken, Elizabeth Van, Henau, Kris, Dimitrova, Nadya, Sekerija, Mario, Dušek, Ladislav, Mägi, Margit, Malila, Nea, Leinonen, Maarit, Velten, Michel, Troussard, Xavier, Bouvier, Veronique, Guizard, Anne-Valérie, Bouvier, Anne-Marie, Arveux, Patrick, Maynadié, Marc, Woronoff, Anne-Sophie, Robaszkiewicz, Michel, Baldi, Isabelle, Monnereau, Alain, Tretarre, Brigitte, Colonna, Marc, Molinié, Florence, Bara, Simona, Schvartz, Claire, Lapôtre-Ledoux, Bénédicte, Grosclaude, Pascale, Stabenow, Roland, Luttmann, Sabine, Nennecke, Alice, Engel, Jutta, Schubert-Fritschle, Gabriele, Heidrich, Jan, Holleczek, Bernd, Jónasson, Jón Gunnlaugur, Clough-Gorr, Kerri, Comber, Harry, Mazzoleni, Guido, Giacomin, Adriano, Sardo, Antonella Sutera, Barchielli, Alessandro, Serraino, Diego, De Angelis, Roberta, Mallone, Sandra, Tavilla, Andrea, Pierannunzio, Daniela, Rossi, Silvia, Santaquilani, Mariano, Knijn, Arnold, Pannozzo, Fabio, Gennaro, Valerio, Benfatto, Lucia, Ricci, Paolo, Autelitano, Mariangela, Spagnoli, Gianbattista, Fusco, Mario, Usala, Mario, Vitale, Francesco, Michiara, Maria, Tumino, Rosario, Mangone, Lucia, Falcini, Fabio, Ferretti, Stefano, Angela Filiberti, Rosa, Marani, Enza, Iannelli, Arturo, Sensi, Flavio, Piffer, Silvano, Gentilini, Maria, Madeddu, Anselmo, Ziino, Antonio, Maspero, Sergio, Candela, Pina, Stracci, Fabrizio, Tagliabue, Giovanna, Rugge, Massimo, Trama, Annalisa, Gatta, Gemma, Botta, Laura, Capocaccia, Riccardo, Pildava, Santa, Smailyte, Giedre, Calleja, Neville, Johannesen, Tom Børge, Rachtan, Jadwiga, Góźdź, Stanisław, Błaszczyk, Jerzy, Kępska, Kamila, de Lacerda, Gonçalo Forjaz, Bento, Maria José, Miranda, Ana, Diba, Chakameh Safaei, Almar, Enrique, Larrañaga, Nerea, de Munain, Arantza Lopez, Torrella-Ramos, Ana, Díaz García, José María, Marcos-Gragera, Rafael, Sanchez, Maria Josè, Navarro, Carmen, Salmeron, Diego, Moreno-Iribas, Conchi, Galceran, Jaume, Carulla, Marià, Mousavi, Mohsen, Bouchardy, Christine, Ess, Silvia M., Bordoni, Andrea, Konzelmann, Isabelle, Rashbass, Jem, Gavin, Anna, Brewster, David H., Huws, Dyfed Wyn, Visser, Otto, Bielska-Lasota, Magdalena, Primic-Zakelj, Maja, Kunkler, Ian, Benhamou, Ellen, Imbimbo, Martina, Maury, Jean-Michel, Garassino, Marina, and Girard, Nicolas

Published
2019
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10. Treatment challenges in and outside a specialist network setting: Pancreatic neuroendocrine tumours

Author

Hackl, Monika, Van Eycken, Elizabeth, Henau, Kris, Dimitrova, Nadya, Sekerija, Mario, Dušek, Ladislav, Mägi, Margit, Malila, Nea, Leinonen, Maarit, Velten, Michel, Troussard, Xavier, Bouvier, Veronique, Guizard, Anne-Valérie, Bouvier, Anne-Marie, Arveux, Patrick, Maynadié, Marc, Woronoff, Anne-Sophie, Robaszkiewicz, Michel, Baldi, Isabelle, Monnereau, Alain, Tretarre, Brigitte, Colonna, Marc, Molinié, Florence, Bara, Simona, Schvartz, Claire, Lapôtre-Ledoux, Bénédicte, Grosclaude, Pascale, Stabenow, Roland, Luttmann, Sabine, Nennecke, Alice, Engel, Jutta, Schubert-Fritschle, Gabriele, Heidrich, Jan, Holleczek, Bernd, Jónasson, Jón Gunnlaugur, Clough-Gorr, Kerri, Comber, Harry, Mazzoleni, Guido, Giacomin, Adriano, Sardo, Antonella Sutera, Barchielli, Alessandro, Serraino, Diego, De Angelis, Roberta, Mallone, Sandra, Tavilla, Andrea, Pierannunzio, Daniela, Rossi, Silvia, Santaquilani, Mariano, Knijn, Arnold, Pannozzo, Fabio, Gennaro, Valerio, Benfatto, Lucia, Ricci, Paolo, Autelitano, Mariangela, Spagnoli, Gianbattista, Fusco, Mario, Usala, Mario, Vitale, Francesco, Michiara, Maria, Tumino, Rosario, Mangone, Lucia, Falcini, Fabio, Ferretti, Stefano, Filiberti, Rosa Angela, Marani, Enza, Iannelli, Arturo, Sensi, Flavio, Piffer, Silvano, Gentilini, Maria, Madeddu, Anselmo, Ziino, Antonio, Maspero, Sergio, Candela, Pina, Stracci, Fabrizio, Tagliabue, Giovanna, Rugge, Massimo, Trama, Annalisa, Gatta, Gemma, Botta, Laura, Capocaccia, Riccardo, Pildava, Santa, Smailyte, Giedre, Calleja, Neville, Johannesen, Tom Børge, Rachtan, Jadwiga, Góźdź, Stanisław, Błaszczyk, Jerzy, Kępska, Kamila, de Lacerda, Gonçalo Forjaz, Bento, Maria José, Miranda, Ana, Diba, Chakameh Safaei, Almar, Enrique, Larrañaga, Nerea, de Munain, Arantza Lopez, Torrella-Ramos, Ana, Díaz García, José María, Marcos-Gragera, Rafael, Sanchez, Maria Josè, Navarro, Carmen, Salmeron, Diego, Moreno-Iribas, Conchi, Galceran, Jaume, Carulla, Marià, Mousavi, Mohsen, Bouchardy, Christine, Ess, Silvia M., Bordoni, Andrea, Konzelmann, Isabelle, Rashbass, Jem, Gavin, Anna, Brewster, David H., Huws, Dyfed Wyn, Visser, Otto, Bielska-Lasota, Magdalena, Primic-Zakelj, Maja, Kunkler, Ian, Benhamou, Ellen, Lykoudis, Panagis M., Partelli, Stefano, Muffatti, Francesca, Caplin, Martyn, Falconi, Massimo, and Fusai, Giuseppe K.

Published
2019
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11. Rare ovarian tumours: Epidemiology, treatment challenges in and outside a network setting

Author

Hackl, Monika, Van Eycken, Elizabeth, Henau, Kris, Dimitrova, Nadya, Sekerija, Mario, Dušek, Ladislav, Mägi, Margit, Malila, Nea, Leinonen, Maarit, Velten, Michel, Troussard, Xavier, Bouvier, Veronique, Guizard, Anne-Valérie, Bouvier, Anne-Marie, Arveux, Patrick, Maynadié, Marc, Woronoff, Anne-Sophie, Robaszkiewicz, Michel, Baldi, Isabelle, Monnereau, Alain, Tretarre, Brigitte, Colonna, Marc, Molinié, Florence, Bara, Simona, Schvartz, Claire, Lapôtre-Ledoux, Bénédicte, Grosclaude, Pascale, Stabenow, Roland, Luttmann, Sabine, Nennecke, Alice, Engel, Jutta, Schubert-Fritschle, Gabriele, Heidrich, Jan, Holleczek, Bernd, Jónasson, Jón Gunnlaugur, Clough-Gorr, Kerri, Comber, Harry, Mazzoleni, Guido, Giacomin, Adriano, Sardo, Antonella Sutera, Barchielli, Alessandro, Serraino, Diego, De Angelis, Roberta, Mallone, Sandra, Tavilla, Andrea, Pierannunzio, Daniela, Rossi, Silvia, Santaquilani, Mariano, Knijn, Arnold, Pannozzo, Fabio, Gennaro, Valerio, Benfatto, Lucia, Ricci, Paolo, Autelitano, Mariangela, Spagnoli, Gianbattista, Fusco, Mario, Usala, Mario, Vitale, Francesco, Michiara, Maria, Tumino, Rosario, Mangone, Lucia, Falcini, Fabio, Ferretti, Stefano, Filiberti, Rosa Angela, Marani, Enza, Iannelli, Arturo, Sensi, Flavio, Piffer, Silvano, Gentilini, Maria, Madeddu, Anselmo, Ziino, Antonio, Maspero, Sergio, Candela, Pina, Stracci, Fabrizio, Tagliabue, Giovanna, Rugge, Massimo, Trama, Annalisa, Gatta, Gemma, Botta, Laura, Capocaccia, Riccardo, Pildava, Santa, Smailyte, Giedre, Calleja, Neville, Johannesen, Tom Børge, Rachtan, Jadwiga, Góźdź, Stanisław, Błaszczyk, Jerzy, Kępska, Kamila, de Lacerda, Gonçalo Forjaz, José Bento, Maria, Miranda, Ana, Safaei Diba, Chakameh, Almar, Enrique, Larrañaga, Nerea, de Munain, Arantza Lopez, Torrella-Ramos, Ana, Díaz García, José María, Marcos-Gragera, Rafael, Josè Sanchez, Maria, Navarro, Carmen, Salmeron, Diego, Moreno-Iribas, Conchi, Galceran, Jaume, Carulla, Marià, Mousavi, Mohsen, Bouchardy, Christine, Ess, Silvia M., Bordoni, Andrea, Konzelmann, Isabelle, Rashbass, Jem, Gavin, Anna, Brewster, David H., Huws, Dyfed Wyn, Visser, Otto, Bielska-Lasota, Magdalena, Primic-Zakelj, Maja, Kunkler, Ian, Benhamou, Ellen, Ray-Coquard, I., Trama, AnnaLisa, Seckl, M.J., Fotopoulou, C., Pautier, P., Pignata, S., Kristensen, G., Mangili, G., Falconer, H., Massuger, L., Sehouli, J., Pujade-Lauraine, E., Lorusso, D., Amant, F., Rokkones, E., Vergote, I., and Ledermann, J.A.

Published
2019
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12. Epidemiology of rare cancers and inequalities in oncologic outcomes

Author

Hackl, Monika, Eycken, Elizabeth Van, Henau, Kris, Dimitrova, Nadya, Sekerija, Mario, Dušek, Ladislav, Mägi, Margit, Malila, Nea, Leinonen, Maarit, Velten, Michel, Troussard, Xavier, Bouvier, Veronique, Guizard, Anne-Valérie, Bouvier, Anne-Marie, Arveux, Patrick, Maynadié, Marc, Woronoff, Anne-Sophie, Robaszkiewicz, Michel, Baldi, Isabelle, Monnereau, Alain, Tretarre, Brigitte, Colonna, Marc, Molinié, Florence, Bara, Simona, Schvartz, Claire, Lapôtre-Ledoux, Bénédicte, Grosclaude, Pascale, Stabenow, Roland, Luttmann, Sabine, Nennecke, Alice, Engel, Jutta, Schubert-Fritschle, Gabriele, Heidrich, Jan, Holleczek, Bernd, Jónasson, Jón Gunnlaugur, Clough-Gorr, Kerri, Comber, Harry, Mazzoleni, Guido, Giacomin, Adriano, Sardo, Antonella Sutera, Barchielli, Alessandro, Serraino, Diego, De Angelis, Roberta, Mallone, Sandra, Tavilla, Andrea, Pierannunzio, Daniela, Rossi, Silvia, Santaquilani, Mariano, Knijn, Arnold, Pannozzo, Fabio, Gennaro, Valerio, Benfatto, Lucia, Ricci, Paolo, Autelitano, Mariangela, Spagnoli, Gianbattista, Fusco, Mario, Usala, Mario, Vitale, Francesco, Michiara, Maria, Tumino, Rosario, Mangone, Lucia, Falcini, Fabio, Ferretti, Stefano, Filiberti, Rosa Angela, Marani, Enza, Iannelli, Arturo, Sensi, Flavio, Piffer, Silvano, Gentilini, Maria, Madeddu, Anselmo, Ziino, Antonio, Maspero, Sergio, Candela, Pina, Stracci, Fabrizio, Tagliabue, Giovanna, Rugge, Massimo, Trama, Annalisa, Gatta, Gemma, Botta, Laura, Capocaccia, Riccardo, Pildava, Santa, Smailyte, Giedre, Calleja, Neville, Johannesen, Tom Børge, Rachtan, Jadwiga, Góźdź, Stanisław, Błaszczyk, Jerzy, Kępska, Kamila, de Lacerda, Forjaz, Bento, Maria José, Miranda, Ana, Diba, Chakameh Safaei, Almar, Enrique, Larrañaga, Nerea, de Munain, Arantza Lopez, Torrella-Ramos, Ana, Díaz García, José María, Marcos-Gragera, Rafael, Sanchez, Maria Josè, Navarro, Carmen, Salmeron, Diego, Moreno-Iribas, Conchi, Galceran, Jaume, Carulla, Marià, Mousavi, Mohsen, Bouchardy, Christine, Ess, Silvia M., Bordoni, Andrea, Konzelmann, Isabelle, Rashbass, Jem, Gavin, Anna, Brewster, David H., Huws, Dyfed Wyn, Visser, Otto, Bielska-Lasota, Magdalena, Primic-Zakelj, Maja, Kunkler, Ian, Benhamou, Ellen, Gatta, G., Trama, A., and Capocaccia, R.

Published
2019
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13. Treatment challenges in and outside a network setting: Soft tissue sarcomas

Author

Hackl, Monika, Van Eycken, Elizabeth, Henau, Kris, Dimitrova, Nadya, Sekerija, Mario, Dušek, Ladislav, Mägi, Margit, Malila, Nea, Leinonen, Maarit, Velten, Michel, Troussard, Xavier, Bouvier, Veronique, Guizard, Anne-Valérie, Bouvier, Anne-Marie, Arveux, Patrick, Maynadié, Marc, Woronoff, Anne-Sophie, Robaszkiewicz, Michel, Baldi, Isabelle, Monnereau, Alain, Tretarre, Brigitte, Colonna, Marc, Molinié, Florence, Bara, Simona, Schvartz, Claire, Lapôtre-Ledoux, Bénédicte, Grosclaude, Pascale, Stabenow, Roland, Luttmann, Sabine, Nennecke, Alice, Engel, Jutta, Schubert-Fritschle, Gabriele, Heidrich, Jan, Bernd Holleczek, Jónasson, Jón Gunnlaugur, Clough-Gorr, Kerri, Comber, Harry, Mazzoleni, Guido, Giacomin, Adriano, Sardo, Antonella Sutera, Barchielli, Alessandro, Serraino, Diego, De Angelis, Roberta, Mallone, Sandra, Tavilla, Andrea, Pierannunzio, Daniela, Rossi, Silvia, Santaquilani, Mariano, Knijn, Arnold, Pannozzo, Fabio, Gennaro, Valerio, Benfatto, Lucia, Ricci, Paolo, Autelitano, Mariangela, Spagnoli, Gianbattista, Fusco, Mario, Usala, Mario, Vitale, Francesco, Michiara, Maria, Tumino, Rosario, Mangone, Lucia, Falcini, Fabio, Ferretti, Stefano, Filiberti, Rosa Angela, Marani, Enza, Iannelli, Arturo, Sensi, Flavio, Piffer, Silvano, Gentilini, Maria, Madeddu, Anselmo, Ziino, Antonio, Maspero, Sergio, Candela, Pina, Stracci, Fabrizio, Tagliabue, Giovanna, Rugge, Massimo, Trama, Annalisa, Gatta, Gemma, Botta, Laura, Capocaccia, Riccardo, Pildava, Santa, Smailyte, Giedre, Calleja, Neville, Johannesen, Tom Børge, Rachtan, Jadwiga, Góźdź, Stanisław, Błaszczyk, Jerzy, Kępska, Kamila, de Lacerda, Gonçalo Forjaz, Bento, Maria José, Miranda, Ana, Diba, Chakameh Safaei, Almar, Enrique, Larrañaga, Nerea, de Munain, Arantza Lopez, Torrella-Ramos, Ana, Díaz García, José María, Marcos-Gragera, Rafael, Sanchez, Maria Josè, Navarro, Carmen, Salmeron, Diego, Moreno-Iribas, Conchi, Galceran, Jaume, Carulla, Marià, Mousavi, Mohsen, Bouchardy, Christine, Ess, Silvia M., Bordoni, Andrea, Konzelmann, Isabelle, Rashbass, Jem, Gavin, Anna, Brewster, David H., Huws, Dyfed Wyn, Visser, Otto, Bielska-Lasota, Magdalena, Primic-Zakelj, Maja, Kunkler, Ian, Benhamou, Ellen, Pasquali, Sandro, Bonvalot, Sylvie, Tzanis, Dimitri, Casali, Paolo G., and Gronchi, Alessandro

Published
2019
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17. Supplementary Figure from Cancer Prevention with Resistant Starch in Lynch Syndrome Patients in the CAPP2-Randomized Placebo Controlled Trial: Planned 10-Year Follow-up

Author

Mathers, John C., primary, Elliott, Faye, primary, Macrae, Finlay, primary, Mecklin, Jukka-Pekka, primary, Möslein, Gabriela, primary, McRonald, Fiona E., primary, Bertario, Lucio, primary, Evans, D. Gareth, primary, Gerdes, Anne-Marie, primary, Ho, Judy W.C., primary, Lindblom, Annika, primary, Morrison, Patrick J., primary, Rashbass, Jem, primary, Ramesar, Raj S., primary, Seppälä, Toni T., primary, Thomas, Huw J.W., primary, Sheth, Harsh J., primary, Pylvänäinen, Kirsi, primary, Reed, Lynn, primary, Borthwick, Gillian M., primary, Bishop, D. Timothy, primary, and Burn, John, primary

Published
2023
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18. Data from Cancer Prevention with Resistant Starch in Lynch Syndrome Patients in the CAPP2-Randomized Placebo Controlled Trial: Planned 10-Year Follow-up

Author

Mathers, John C., primary, Elliott, Faye, primary, Macrae, Finlay, primary, Mecklin, Jukka-Pekka, primary, Möslein, Gabriela, primary, McRonald, Fiona E., primary, Bertario, Lucio, primary, Evans, D. Gareth, primary, Gerdes, Anne-Marie, primary, Ho, Judy W.C., primary, Lindblom, Annika, primary, Morrison, Patrick J., primary, Rashbass, Jem, primary, Ramesar, Raj S., primary, Seppälä, Toni T., primary, Thomas, Huw J.W., primary, Sheth, Harsh J., primary, Pylvänäinen, Kirsi, primary, Reed, Lynn, primary, Borthwick, Gillian M., primary, Bishop, D. Timothy, primary, and Burn, John, primary

Published
2023
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20. Traceability and Timeliness in Messaging Middleware

Author

Shand, Brian, Rashbass, Jem, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Meersman, Robert, editor, Tari, Zahir, editor, and Herrero, Pilar, editor

Published
2006
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21. Worldwide trends in population-based survival for children, adolescents, and young adults diagnosed with leukaemia, by subtype, during 2000–14 (CONCORD-3): analysis of individual data from 258 cancer registries in 61 countries

Author

Ssenyonga, Naomi, primary, Stiller, Charles, additional, Nakata, Kayo, additional, Shalkow, Jaime, additional, Redmond, Shelagh, additional, Bulliard, Jean-Luc, additional, Girardi, Fabio, additional, Fowler, Christine, additional, Marcos-Gragera, Rafael, additional, Bonaventure, Audrey, additional, Saint-Jacques, Nathalie, additional, Minicozzi, Pamela, additional, De, Prithwish, additional, Rodríguez-Barranco, Miguel, additional, Larønningen, Siri, additional, Di Carlo, Veronica, additional, Mägi, Margit, additional, Valkov, Mikhail, additional, Seppä, Karri, additional, Wyn Huws, Dyfed, additional, Coleman, Michel P, additional, Allemani, Claudia, additional, Bouzbid, Sabiha, additional, Hamdi-Chérif, Mokhtar, additional, Kara, Lamia, additional, Meguenni, Kaouel, additional, Regagba, Derbali, additional, Bayo, Sine, additional, Cheick Bougadari, Traore, additional, Manraj, Shyam Shunker, additional, Bendahhou, Karima, additional, Ladipo, Akinade, additional, Ogunbiyi, Olufemi, additional, Somdyala, Nontuthuzelo, additional, Chaplin, María Agustina, additional, Moreno, Florencia, additional, Calabrano, Gladis, additional, Espinola, Silvia, additional, Carballo Quintero, Beatriz, additional, Fita, Rosalba, additional, Laspada, Walter, additional, Ibañez, Susana, additional, Lima, Carlos, additional, Mafra Da Costa, Allini, additional, De Souza, Paulo César, additional, Chaves, Juliana, additional, Laporte, Cyntia, additional, Curado, Maria Paula, additional, de Oliveira, Jose Carlos, additional, Veneziano, Claudia, additional, Veneziano, Donaldo, additional, Almeida, Ana Beatriz, additional, Latorre, Maria, additional, Azevedo e Silva, Gulnar, additional, Rebelo, Marise, additional, Santos, Marceli, additional, Galaz, Juan, additional, Aparicio Aravena, Mackarena, additional, Sanhueza Monsalve, Jocelyn, additional, Herrmann, Denise, additional, Vargas, Solange, additional, Herrera, Victor, additional, Uribe, Claudia, additional, Bravo, Luis Eduardo, additional, Garcia, Luz Stella, additional, Arias-Ortiz, Nelson, additional, Morantes, Daniela, additional, Jurado, Daniel, additional, Yépez Chamorro, María, additional, Delgado, Sandra, additional, Ramirez, Melissa, additional, Galán Alvarez, Yaima, additional, Torres, Priscila, additional, Martínez-Reyes, Fray, additional, Jaramillo, Leyda, additional, Quinto, Rina, additional, Castillo, Jhoanna, additional, Mendoza, Mariela, additional, Cueva, Patricia, additional, Yépez, José, additional, Bhakkan, Bernard, additional, Deloumeaux, Jacqueline, additional, Joachim, Clarisse, additional, Macni, Jonathan, additional, Carrillo, Rodolfo, additional, Shalkow Klincovstein, Jaime, additional, Rivera Gomez, Rebeca, additional, Perez, Patricia, additional, Poquioma, Ebert, additional, Tortolero-Luna, Guillermo, additional, Zavala, Diego, additional, Alonso, Rafael, additional, Barrios, Enrique, additional, Eckstrand, Angela, additional, Nikiforuk, Cindy, additional, Woods, Ryan, additional, Noonan, Gail, additional, Turner, Donna, additional, Kumar, Eshwar, additional, Zhang, Bin, additional, Dowden, Jeff, additional, Doyle, Gregory, additional, Walsh, Gordon, additional, Anam, Aniq, additional, McClure, Carol, additional, Vriends, Kim, additional, Bertrand, Christine, additional, Ramanakumar, Agnihotram, additional, Kozie, Serena, additional, Stuart-Panko, Heather, additional, Freeman, Tara, additional, George, Justin, additional, Avila, Rosa, additional, O'Brien, David, additional, Holt, Abby, additional, Almon, Lyn, additional, Ward, Kevin, additional, Kwong, Sandy, additional, Morris, Cyllene, additional, Rycroft, Randi, additional, Mueller, Lloyd, additional, Phillips, Cathryn, additional, Brown, Heather, additional, Cromartie, Betsy, additional, Ruterbusch, Julie, additional, Schwartz, Ann, additional, Levin, Gary, additional, Wohler, Brad, additional, Bayakly, Rana, additional, Gomez, Scarlett, additional, McKinley, Meg, additional, Cress, Rosemary, additional, Davis, Joni, additional, Hernandez, Brenda, additional, Johnson, Christopher, additional, Morawski, Bozena, additional, Ruppert, Laura, additional, Bentler, Suzanne, additional, Charlton, Mary, additional, Huang, Bin, additional, Tucker, Thomas, additional, Deapen, Dennis, additional, Liu, Lihua, additional, Hsieh, Mei-Chin, additional, Wu, Xiao-Cheng, additional, Schwenn, Molly, additional, Stern, Kimberly, additional, Gershman, Susan, additional, Knowlton, Richard, additional, Alverson, Georgetta, additional, Weaver, Tamara, additional, Desai, Jay, additional, Rogers, Deirdre, additional, Jackson-Thompson, Jeanette, additional, Lemons, Debbi, additional, Zimmerman, Heather, additional, Hood, Michelle, additional, Roberts-Johnson, Jenifer, additional, Hammond, Whitney, additional, Rees, Judith, additional, Pawlish, Karen, additional, Stroup, Antoinette, additional, Key, Charles, additional, Wiggins, Charles, additional, Kahn, Amy, additional, Schymura, Maria, additional, Radhakrishnan, Soundarya, additional, Rao, Chandrika, additional, Giljahn, Lynn, additional, Slocumb, Roberta, additional, Dabbs, Christy, additional, Espinoza, Raffaella, additional, Aird, Karen, additional, Beran, Todd, additional, Rubertone, Jim, additional, Slack, Stephen, additional, Oh, Junhie, additional, Janes, Tiffany, additional, Schwartz, Stephen, additional, Chiodini, Stephanie, additional, Hurley, Deborah, additional, Whiteside, Martin, additional, Rai, Saroj, additional, Williams, Melanie, additional, Herget, Kim, additional, Sweeney, Carol, additional, Johnson, Alison, additional, Keitheri Cheteri, Mahesh, additional, Migliore Santiago, Patti, additional, Blankenship, Steven, additional, Farley, Shawn, additional, Borchers, Robert, additional, Malicki, Robin, additional, Espinoza, Julia, additional, Grandpre, Joseph, additional, Edwards, Brenda, additional, Mariotto, Angela, additional, Weir, Hannah, additional, Wilson, Reda, additional, Wang, Ning, additional, Yang, Lei, additional, Chen, Jian-Shun, additional, He, Yu-Tong, additional, Song, Guo-Hui, additional, Gu, Xiao-Ping, additional, Mei, Dan, additional, Ge, Heng-Ming, additional, Wu, Tong-Hao, additional, Li, Yan-Yan, additional, Zhao, De-Li, additional, Jin, Feng, additional, Zhang, Jian-Hua, additional, Zhu, Feng-Dong, additional, Junhua, Qian, additional, Yang, Yan Lei, additional, Jiang, Chun-Xiao, additional, Biao, Wang, additional, Wang, Jian, additional, Li, Qi-Long, additional, Yi, He, additional, Zhou, Xin, additional, Dong, JianMei, additional, Li, WeiWei, additional, Fu, Fang-Xian, additional, Chen, Jian-Guo, additional, Zhu, Jian, additional, Li, Yan-Hua, additional, Lu, Yu-Qiang, additional, Fan, Min, additional, Huang, Su-Qin, additional, Guo, Guo-Ping, additional, Zhaolai, Hua, additional, Wei, Kuangrong, additional, Chen, Wan-Qing, additional, Wei, Wenqiang, additional, Zeng, Hongmei, additional, Demetriou, Anna, additional, Mang, Wai Kong, additional, Ngan, Kai Cheong, additional, Kataki, Amal, additional, Krishnatreya, Manigreeva, additional, Jayalekshmi, Padmavathi Amma, additional, Sebastian, Paul, additional, George, Preethi, additional, Mathew, Aleyamma, additional, Nandakumar, Ambakumar, additional, Malekzadeh, Reza, additional, Roshandel, Gholamreza, additional, Keinan-Boker, Lital, additional, Silverman, Barbara, additional, Ito, Hidemi, additional, Koyanagi, Yuriko, additional, Sato, Masako, additional, Tobori, Fumio, additional, Nakata, Ichiro, additional, Teramoto, Norihiro, additional, Hattori, Masakazu, additional, Kaizaki, Yasuharu, additional, Moki, Fumitaka, additional, Sugiyama, Hiromi, additional, Utada, Mai, additional, Nishimura, Makiko, additional, Yoshida, Keiichi, additional, Kurosawa, Katsuki, additional, Nemoto, Yuji, additional, Narimatsu, Hiroto, additional, Sakaguchi, Masahiko, additional, Kanemura, Seiki, additional, Naito, Michiko, additional, Narisawa, Rintaro, additional, Miyashiro, Isao, additional, Mori, Daisuke, additional, Yoshitake, Mayuko, additional, Oki, Izumi, additional, Fukushima, Norimasa, additional, Shibata, Akiko, additional, Iwasa, Keiichiro, additional, Ono, Chie, additional, Matsuda, Tomohiro, additional, Nimri, Omar, additional, Jung, Kyu-Won, additional, Won, Young-Joo, additional, Alawadhi, Eiman, additional, Elbasmi, Amani, additional, Ab Manan, Azizah, additional, Adam, Farzaana, additional, Nansalmaa, Erdenekhuu, additional, Tudev, Undarmaa, additional, Ochir, Chimedsuren, additional, Al Khater, Al Hareth, additional, El Mistiri, Mufid, additional, Lim, Gek Hsiang, additional, Teo, Yik Ying, additional, Chiang, Chun-Ju, additional, Lee, Wen-Chung, additional, Buasom, Rangsiya, additional, Sangrajrang, Suleeporn, additional, Suwanrungruang, Krittika, additional, Vatanasapt, Patravoot, additional, Daoprasert, Karnchana, additional, Pongnikorn, Donsuk, additional, Leklob, Atit, additional, Sangkitipaiboon, Somphob, additional, Geater, Sarayut, additional, Sriplung, Hutcha, additional, Ceylan, Okan, additional, Kög, Iskender, additional, Dirican, Oya, additional, Köse, Tülay, additional, Gurbuz, Tulın, additional, Karašahin, Füsun Emine, additional, Turhan, Duygu, additional, Aktaş, Umut, additional, Halat, Yakup, additional, Eser, Sultan, additional, Yakut, Cankut, additional, Altinisik, Merve, additional, Cavusoglu, Yasar, additional, Türkköylü, Ayşe, additional, Üçüncü, Nuršen, additional, Hackl, Monika, additional, Zborovskaya, Anna, additional, Aleinikova, Olga, additional, Henau, Kris, additional, Van Eycken, Liesbet, additional, Atanasov, Trayan, additional, Valerianova, Zdravka, additional, Šekerija, Mario, additional, Dušek, Ladislav, additional, Zvolský, Miroslav, additional, Steinrud Mørch, Lina, additional, Storm, Hans, additional, Wessel Skovlund, Charlotte, additional, Innos, Kaire, additional, Malila, Nea, additional, Jégu, Jérémie, additional, Velten, Michel, additional, Cornet, Edouard, additional, Troussard, Xavier, additional, Bouvier, Anne-Marie, additional, Guizard, Anne-Valérie, additional, Bouvier, Véronique, additional, Launoy, Guy, additional, Dabakuyo Yonli, Sandrine, additional, Poillot, Marie-Laure, additional, Maynadié, Marc, additional, Mounier, Morgane, additional, Vaconnet, Lina, additional, Woronoff, Anne-Sophie, additional, Daoulas, Mélanie, additional, Robaszkiewicz, Michel, additional, Clavel, Jacqueline, additional, Poulalhon, Claire, additional, Desandes, Emmanuel, additional, Lacour, Brigitte, additional, Baldi, Isabelle, additional, Pouchieu, Camille, additional, Amadeo, Brice, additional, Coureau, Gaëlle, additional, Monnereau, Alain, additional, Audoin, Magali, additional, D'Almeida, Tania, additional, Boyer, Séverine, additional, Hammas, Karima, additional, Trétarre, Brigitte, additional, Colonna, Marc, additional, Delafosse, Patricia, additional, Plouvier, Sandrine, additional, Cowppli-Bony, Anne, additional, Molinié, Florence, additional, Bara, Simona, additional, Ganry, Olivier, additional, Lapôtre-Ledoux, Bénédicte, additional, Daubisse-Marliac, Laetitia, additional, Bossard, Nadine, additional, Estève, Jacques, additional, Uhry, Zoé, additional, Stabenow, Roland, additional, Wilsdorf-Köhler, Heide, additional, Eberle, Andrea, additional, Luttmann, Sabine, additional, Löhden, Imma, additional, Nennecke, Alice, additional, Kieschke, Joachim, additional, Sirri, Eunice, additional, Justenhoven, Christina, additional, Zeissig, Sylke, additional, Holleczek, Bernd, additional, Eisemann, Nora, additional, Katalinic, Alexander, additional, Asquez, Rachelle, additional, Kumar, Vijay, additional, Petridou, Eleni, additional, Ólafsdóttir, Elínborg, additional, Tryggvadóttir, Laufey, additional, Murray, Deirdre, additional, Walsh, Paul, additional, Sundseth, Hildrun, additional, Mazzoleni, Guido, additional, Vittadello, Fabio, additional, Coviello, Enzo, additional, Cuccaro, Francesco, additional, Galasso, Rocco, additional, Sampietro, Giuseppe, additional, Magoni, Michele, additional, Ardizzone, Antonino, additional, D'Argenzio, Angelo, additional, Di Prima, Alessia Anna, additional, Ippolito, Antonella, additional, Lavecchia, Anna Maria, additional, Sutera Sardo, Antonella, additional, Gola, Gemma, additional, Ballotari, Paola, additional, Giacomazzi, Erica, additional, Ferretti, Stefano, additional, Dal Maso, Luigino, additional, Serraino, Diego, additional, Celesia, Maria Vittoria, additional, Filiberti, Rosa Angela, additional, Pannozzo, Fabio, additional, Melcarne, Anna, additional, Quarta, Fabrizio, additional, Andreano, Anita, additional, Russo, Antonio Giampiero, additional, Carrozzi, Giuliano, additional, Cirilli, Claudia, additional, Cavalieri d'Oro, Luca, additional, Rognoni, Magda, additional, Fusco, Mario, additional, Vitale, Maria Francesca, additional, Usala, Mario, additional, Cusimano, Rosanna, additional, Mazzucco, Walter, additional, Michiara, Maria, additional, Sgargi, Paolo, additional, Boschetti, Lorenza, additional, Chiaranda, Giorgio, additional, Seghini, Pietro, additional, Maule, Milena, additional, Merletti, Franco, additional, Spata, Eugenia, additional, Tumino, Rosario, additional, Mancuso, Pamela, additional, Vicentini, Massimo, additional, Cassetti, Tiziana, additional, Sassatelli, Romano, additional, Falcini, Fabio, additional, Giorgetti, Stefania, additional, Caiazzo, Anna Luisa, additional, Cavallo, Rossella, additional, Piras, Daniela, additional, Bella, Francesca, additional, Madeddu, Anselmo, additional, Fanetti, Anna Clara, additional, Maspero, Sergio, additional, Carone, Simona, additional, Mincuzzi, Antonia, additional, Candela, Giuseppa, additional, Scuderi, Tiziana, additional, Gentilini, Maria Adalgisa, additional, Rizzello, Roberto, additional, Rosso, Stefano, additional, Zanetti, Roberto, additional, Caldarella, Adele, additional, Intrieri, Teresa, additional, Bianconi, Fortunato, additional, Stracci, Fabrizio, additional, Contiero, Paolo, additional, Tagliabue, Giovanna, additional, Rugge, Massimo, additional, Zorzi, Manuel, additional, Beggiato, Simonetta, additional, Brustolin, Angelita, additional, De Angelis, Roberta, additional, Gatta, Gemma, additional, Maurina, Anita, additional, Oniščuka, Marija, additional, Mousavi, Mohsen, additional, Lipunova, Nadezda, additional, Vincerzevskienė, Ieva, additional, Agius, Dominic, additional, Calleja, Neville, additional, Siesling, Sabine, additional, Visser, Otto, additional, Johannesen, Tom, additional, Trojanowski, Maciej, additional, Mierzwa, Tomasz, additional, Rachtan, Jadwiga, additional, Kępska, Kamila, additional, Kościańska, Beata, additional, Wójcik-Tomaszewska, Joanna, additional, Motnyk, Marcin, additional, Gos, Anna, additional, Bielska-Lasota, Magdalena, additional, Didkowska, Joanna, additional, Wojciechowska, Urszula, additional, Forjaz de Lacerda, Gonçalo, additional, Rego, Raul, additional, Carrito, Branca, additional, Pais, Ana, additional, Bento, Maria José, additional, Rodrigues, Jessica, additional, Lourenço, Antonio, additional, Mayer-da-Silva, Alexandra, additional, Blaga, Luminita, additional, Coza, Daniela, additional, Gusenkova, Lubov, additional, Lazarevich, Olga, additional, Prudnikova, Olga, additional, Vjushkov, Dmitri Mikhailovich, additional, Egorova, Alla, additional, Orlov, Andrey, additional, Pikalova, Lidiya, additional, Zhuikova, Lilia, additional, Adamcik, Juraj, additional, Safaei Diba, Chakameh, additional, Zadnik, Vesna, additional, Zagar, Tina, additional, De-La-Cruz, Marta, additional, Lopez-de-Munain, Arantza, additional, Aleman, Araceli, additional, Rojas, Dolores, additional, Chillarón, Rosario Jiménez, additional, Navarro, Ana Isabel Marcos, additional, Puigdemont, Montse, additional, Sánchez Perez, María-José, additional, Franch Sureda, Paula, additional, Ramos Montserrat, Maria, additional, Chirlaque López, Maria Dolores, additional, Sánchez Gil, Antonia, additional, Ardanaz, Eva, additional, Guevara, Marcela, additional, Cañete-Nieto, Adela, additional, Peris-Bonet, Rafael, additional, Carulla, Marià, additional, Galceran, Jaume, additional, Almela, Fernando, additional, Sabater, Consol, additional, Khan, Staffan, additional, Pettersson, David, additional, Dickman, Paul, additional, Staehelin, Katharina, additional, Struchen, Benjamin, additional, Herrmann, Christian, additional, Mousavi, Seyed Mohsen, additional, Egger Hayoz, Céline, additional, Bouchardy, Christine, additional, Schaffar, Robin, additional, Went, Philip, additional, Maspoli-Conconi, Manuela, additional, Kuehni, Claudia, additional, Bordoni, Andrea, additional, Ortelli, Laura, additional, Chiolero, Arnaud, additional, Konzelmann, Isabelle, additional, Rohrmann, Sabine, additional, Wanner, Miriam, additional, Broggio, John, additional, Rashbass, Jem, additional, Fitzpatrick, Deirdre, additional, Gavin, Anna, additional, Morrison, David, additional, Thomson, Catherine, additional, Greene, Giles, additional, Huws, Dyfed, additional, Coleman, Michel, additional, Matz, Melissa, additional, Sanz, Natalia, additional, Ssenyonga, Naomi, additional, Stephens, Richard, additional, Chalker, Elizabeth, additional, Smith, Mirka, additional, Gugusheff, Jessica, additional, You, Hui, additional, Qin Li, Shu, additional, Dugdale, Sarah, additional, Moore, Julie, additional, Philpot, Shoni, additional, Pfeiffer, Rhonda, additional, Thomas, Helen, additional, Silva Ragaini, Bruna, additional, Venn, Alison, additional, Evans, Sue, additional, Te Marvelde, Luc, additional, Savietto, Vedrana, additional, Trevithick, Richard, additional, Currow, David, additional, and Lewis, Chris, additional

Published
2022
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23. Cancer Prevention with Resistant Starch in Lynch Syndrome Patients in the CAPP2-Randomized Placebo Controlled Trial : Planned 10-Year Follow-up

Author

Mathers, John C., Elliott, Faye, Macrae, Finlay, Mecklin, Jukka-pekka, Möslein, Gabriela, Mcronald, Fiona E., Bertario, Lucio, Evans, D. Gareth, Gerdes, Anne-marie, Ho, Judy W.c., Lindblom, Annika, Morrison, Patrick J., Rashbass, Jem, Ramesar, Raj S., Seppälä, Toni T., Thomas, Huw J.w., Sheth, Harsh J., Pylvänäinen, Kirsi, Reed, Lynn, Borthwick, Gillian M., Bishop, D. Timothy, Burn, John, Eccles, Diana, Side, Lucy E., HUS Abdominal Center, and II kirurgian klinikka

Subjects
Cancer Research, LIVER, 3122 Cancers, tärkkelys, COLORECTAL-CANCER, BUTYRATE, SDG 3 - Good Health and Well-being, asetyylisalisyylihappo, Humans, Lynchin oireyhtymä, paksusuolisyöpä, RISK, Incidence, COLON-CANCER, Resistant Starch, Colorectal Neoplasms/drug therapy, CONSUMPTION, Colorectal Neoplasms, Hereditary Nonpolyposis, ASPIRIN, MICROBIOME, Oncology, Aspirin/therapeutic use, CELLS, DIETARY FIBER INTAKE, syöpätaudit, ennaltaehkäisy, seurantatutkimus, Colorectal Neoplasms, Hereditary Nonpolyposis/complications, Colorectal Neoplasms, ilmaantuvuus, Follow-Up Studies
Abstract

Abstract The CAPP2 trial investigated the long-term effects of aspirin and resistant starch on cancer incidence in patients with Lynch syndrome (LS). Participants with LS were randomized double-blind to 30 g resistant starch (RS) daily or placebo for up to 4 years. We present long-term cancer outcomes based on the planned 10-year follow-up from recruitment, supplemented by National Cancer Registry data to 20 years in England, Wales, and Finland. Overall, 463 participants received RS and 455 participants received placebo. After up to 20 years follow-up, there was no difference in colorectal cancer incidence (n = 52 diagnosed with colorectal cancer among those randomized to RS against n = 53 on placebo) but fewer participants had non-colorectal LS cancers in those randomized to RS (n = 27) compared with placebo (n = 48); intention-to-treat (ITT) analysis [HR, 0.54; 95% confidence interval (CI), 0.33–0.86; P = 0.010]. In ITT analysis, allowing for multiple primary cancer diagnoses among participants by calculating incidence rate ratios (IRR) confirmed the protective effect of RS against non–colorectal cancer LS cancers (IRR, 0.52; 95% CI, 0.32–0.84; P = 0.0075). These effects are particularly pronounced for cancers of the upper GI tract; 5 diagnoses in those on RS versus 21 diagnoses on placebo. The reduction in non–colorectal cancer LS cancers was detectable in the first 10 years and continued in the next decade. For colorectal cancer, ITT analysis showed no effect of RS on colorectal cancer risk (HR, 0.92; 95% CI, 0.62–1.34; P = 0.63). There was no interaction between aspirin and RS treatments. In conclusion, 30 g daily RS appears to have a substantial protective effect against non–colorectal cancer cancers for patients with LS. Prevention Relevance: Regular bowel screening and aspirin reduce colorectal cancer among patients with LS but extracolonic cancers are difficult to detect and manage. This study suggests that RS reduces morbidity associated with extracolonic cancers. See related Spotlight, p. 557

Published
2022

25. Harnessing national pan-laboratory data for accurate quantitation of PS4 in cancer susceptibility genes: Cancer Variant Interpretation Group UK (CanVIG-UK)

Author

Garrett, Alice, primary, Loveday, Chey, additional, Durkie, Miranda, additional, Burghel, George, additional, Drummond, James, additional, Robinson, Rachel, additional, Berry, Ian, additional, Wallace, Andrew, additional, King, Laura, additional, Choi, Subin, additional, Soufianopoulou, Eleni, additional, McRonald, Fiona, additional, Santaniello, Francesco, additional, Burn, John, additional, Rashbass, Jem, additional, Hardy, Steven, additional, Eccles, Diana, additional, Tischkowitz, Marc, additional, and Turnbull, Clare, additional

Published
2021
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26. Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study : a double-blind, randomised, placebo-controlled trial

Author

Burn, John, Sheth, Harsh, Elliott, Faye, Reed, Lynn, Macrae, Finlay, Mecklin, Jukka-Pekka, Möslein, Gabriela, McRonald, Fiona E., Bertario, Lucio, Evans, D. Gareth, Gerdes, Anne-Marie, Ho, Judy W. C., Lindblom, Annika, Morrison, Patrick J., Rashbass, Jem, Ramesar, Raj, Seppälä, Toni, Thomas, Huw J. W., Pylvänäinen, Kirsi, Borthwick, Gillian M., Mathers, John C., and Bishop, D. Timothy

Subjects
asetyylisalisyylihappo, syöpätaudit, ennaltaehkäisy, suolistosyövät, Lynchin oireyhtymä
Abstract

Background: Lynch syndrome is associated with an increased risk of colorectal cancer and with a broader spectrum of cancers, especially endometrial cancer. In 2011, our group reported long-term cancer outcomes (mean follow-up 55·7 months [SD 31·4]) for participants with Lynch syndrome enrolled into a randomised trial of daily aspirin versus placebo. This report completes the planned 10-year follow-up to allow a longer-term assessment of the effect of taking regular aspirin in this high-risk population. Methods: In the double-blind, randomised CAPP2 trial, 861 patients from 43 international centres worldwide (707 [82%] from Europe, 112 [13%] from Australasia, 38 [4%] from Africa, and four [

Published
2020

27. Middleware Support for Monitoring: Privacy and Audit in Healthcare Applications

Author

Shand, Brian, Rashbass, Jem, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Meersman, Robert, editor, Tari, Zahir, editor, and Herrero, Pilar, editor

Published
2006
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28. Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study:a double-blind, randomised, placebo-controlled trial

Author

Burn, John, Sheth, Harsh, Elliott, Faye, Reed, Lynn, Macrae, Finlay, Mecklin, Jukka Pekka, Möslein, Gabriela, McRonald, Fiona E., Bertario, Lucio, Evans, D. Gareth, Gerdes, Anne Marie, Ho, Judy W.C., Lindblom, Annika, Morrison, Patrick J., Rashbass, Jem, Ramesar, Raj, Seppälä, Toni, Thomas, Huw J.W., Pylvänäinen, Kirsi, Borthwick, Gillian M., Mathers, John C., Bishop, D. Timothy, Boussioutas, Alex, Brewer, Carole, Cook, Jackie, Eccles, Diana, Ellis, Anthony, Hodgson, Shirley V., Lubinski, Jan, Maher, Eamonn R., Porteous, Mary EM, Sampson, Julian, Scott, Rodney J., Side, Lucy, Burn, John, Sheth, Harsh, Elliott, Faye, Reed, Lynn, Macrae, Finlay, Mecklin, Jukka Pekka, Möslein, Gabriela, McRonald, Fiona E., Bertario, Lucio, Evans, D. Gareth, Gerdes, Anne Marie, Ho, Judy W.C., Lindblom, Annika, Morrison, Patrick J., Rashbass, Jem, Ramesar, Raj, Seppälä, Toni, Thomas, Huw J.W., Pylvänäinen, Kirsi, Borthwick, Gillian M., Mathers, John C., Bishop, D. Timothy, Boussioutas, Alex, Brewer, Carole, Cook, Jackie, Eccles, Diana, Ellis, Anthony, Hodgson, Shirley V., Lubinski, Jan, Maher, Eamonn R., Porteous, Mary EM, Sampson, Julian, Scott, Rodney J., and Side, Lucy

Abstract

Background: Lynch syndrome is associated with an increased risk of colorectal cancer and with a broader spectrum of cancers, especially endometrial cancer. In 2011, our group reported long-term cancer outcomes (mean follow-up 55·7 months [SD 31·4]) for participants with Lynch syndrome enrolled into a randomised trial of daily aspirin versus placebo. This report completes the planned 10-year follow-up to allow a longer-term assessment of the effect of taking regular aspirin in this high-risk population. Methods: In the double-blind, randomised CAPP2 trial, 861 patients from 43 international centres worldwide (707 [82%] from Europe, 112 [13%] from Australasia, 38 [4%] from Africa, and four [<1%] from The Americas) with Lynch syndrome were randomly assigned to receive 600 mg aspirin daily or placebo. Cancer outcomes were monitored for at least 10 years from recruitment with English, Finnish, and Welsh participants being monitored for up to 20 years. The primary endpoint was development of colorectal cancer. Analysis was by intention to treat and per protocol. The trial is registered with the ISRCTN registry, number ISRCTN59521990. Findings: Between January, 1999, and March, 2005, 937 eligible patients with Lynch syndrome, mean age 45 years, commenced treatment, of whom 861 agreed to be randomly assigned to the aspirin group or placebo; 427 (50%) participants received aspirin and 434 (50%) placebo. Participants were followed for a mean of 10 years approximating 8500 person-years. 40 (9%) of 427 participants who received aspirin developed colorectal cancer compared with 58 (13%) of 434 who received placebo. Intention-to-treat Cox proportional hazards analysis revealed a significantly reduced hazard ratio (HR) of 0·65 (95% CI 0·43–0·97; p=0·035) for aspirin versus placebo. Negative binomial regression to account for multiple primary events gave an incidence rate ratio of 0·58 (0·39–0·87; p=0·0085). Per-protocol analyses restricted to 509 who achieved 2 years' interv

Published
2020

33. Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial

Author

Burn, John, primary, Sheth, Harsh, additional, Elliott, Faye, additional, Reed, Lynn, additional, Macrae, Finlay, additional, Mecklin, Jukka-Pekka, additional, Möslein, Gabriela, additional, McRonald, Fiona E, additional, Bertario, Lucio, additional, Evans, D Gareth, additional, Gerdes, Anne-Marie, additional, Ho, Judy W C, additional, Lindblom, Annika, additional, Morrison, Patrick J, additional, Rashbass, Jem, additional, Ramesar, Raj, additional, Seppälä, Toni, additional, Thomas, Huw J W, additional, Pylvänäinen, Kirsi, additional, Borthwick, Gillian M, additional, Mathers, John C, additional, Bishop, D Timothy, additional, Boussioutas, Alex, additional, Brewer, Carole, additional, Cook, Jackie, additional, Eccles, Diana, additional, Ellis, Anthony, additional, Hodgson, Shirley V, additional, Lubinski, Jan, additional, Maher, Eamonn R, additional, Porteous, Mary EM, additional, Sampson, Julian, additional, Scott, Rodney J, additional, and Side, Lucy, additional

Published
2020
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38. Diagnosing cancer in primary care: results from the National Cancer Diagnosis Audit

Author

Swann, Ruth, McPhail, Sean, Witt, Jana, Shand, Brian, Abel, Gary A, Hiom, Sara, Rashbass, Jem, Lyratzopoulos, Georgios, Rubin, Greg, National Cancer Diagnosis Audit Steering Group, Lyratzopoulos, Georgios [0000-0002-2873-7421], and Apollo - University of Cambridge Repository

Subjects
Male, Medical Audit, diagnosis, clinical audit, General Practice, morbidity, Middle Aged, Quality Improvement, investigations, primary care, England, Neoplasms, cancer, Humans, Female, Health Services Research, Delivery of Health Care, Referral and Consultation, Early Detection of Cancer, Aged
Abstract

BACKGROUND: Continual improvements in diagnostic processes are needed to minimise the proportion of patients with cancer who experience diagnostic delays. Clinical audit is a means of achieving this. AIM: To characterise key aspects of the diagnostic process for cancer and to generate baseline measures for future re-audit. DESIGN AND SETTING: Clinical audit of cancer diagnosis in general practices in England. METHOD: Information on patient and tumour characteristics held in the English National Cancer Registry was supplemented by information from GPs in participating practices. Data items included diagnostic timepoints, patient characteristics, and clinical management. RESULTS: Data were collected on 17 042 patients with a new diagnosis of cancer during 2014 from 439 practices. Participating practices were similar to non-participating ones, particularly regarding population age, urban/rural location, and practice-based patient experience measures. The median diagnostic interval for all patients was 40 days (interquartile range [IQR] 15-86 days). Most patients were referred promptly (median primary care interval 5 days [IQR 0-27 days]). Where GPs deemed diagnostic delays to have occurred (22% of cases), patient, clinician, or system factors were responsible in 26%, 28%, and 34% of instances, respectively. Safety netting was recorded for 44% of patients. At least one primary care-led investigation was carried out for 45% of patients. Most patients (76%) had at least one existing comorbid condition; 21% had three or more. CONCLUSION: The findings identify avenues for quality improvement activity and provide a baseline for future audit of the impact of 2015 National Institute for Health and Care Excellence guidance on management and referral of suspected cancer.

Published
2018
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39. Data resource description: Systemic Anti-Cancer Therapy (SACT) Dataset

Author

Bright, Chloe, primary, Lawton, Sarah, additional, Benson, Stephen, additional, Bomb, Martine, additional, Dodwell, David, additional, Henson, Katherine, additional, McPhail, Sean, additional, Miller, Louise, additional, Rashbass, Jem, additional, Turnball, Alice, additional, and Smittenaar, Rebecca, additional

Published
2019
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41. Data Resource Profile: The Systemic Anti-Cancer Therapy (SACT) dataset

Author

Bright, Chloe J, primary, Lawton, Sarah, additional, Benson, Stephen, additional, Bomb, Martine, additional, Dodwell, David, additional, Henson, Katherine E, additional, McPhail, Sean, additional, Miller, Louise, additional, Rashbass, Jem, additional, Turnbull, Alice, additional, and Smittenaar, Rebecca, additional

Published
2019
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43. Nationwide Incidence of Metastatic Cutaneous Squamous Cell Carcinoma in England

Author

Venables, Zoë C., primary, Autier, Philippe, additional, Nijsten, Tamar, additional, Wong, Kwok F., additional, Langan, Sinéad M., additional, Rous, Brian, additional, Broggio, John, additional, Harwood, Catherine, additional, Henson, Katherine, additional, Proby, Charlotte M., additional, Rashbass, Jem, additional, and Leigh, Irene M., additional

Published
2019
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44. Epidemiology of rare cancers and inequalities in oncologic outcomes

Author

Gatta, G., primary, Trama, A., additional, Capocaccia, R., additional, Hackl, Monika, additional, Eycken, Elizabeth Van, additional, Henau, Kris, additional, Dimitrova, Nadya, additional, Sekerija, Mario, additional, Dušek, Ladislav, additional, Mägi, Margit, additional, Malila, Nea, additional, Leinonen, Maarit, additional, Velten, Michel, additional, Troussard, Xavier, additional, Bouvier, Veronique, additional, Guizard, Anne-Valérie, additional, Bouvier, Anne-Marie, additional, Arveux, Patrick, additional, Maynadié, Marc, additional, Woronoff, Anne-Sophie, additional, Robaszkiewicz, Michel, additional, Baldi, Isabelle, additional, Monnereau, Alain, additional, Tretarre, Brigitte, additional, Colonna, Marc, additional, Molinié, Florence, additional, Bara, Simona, additional, Schvartz, Claire, additional, Lapôtre-Ledoux, Bénédicte, additional, Grosclaude, Pascale, additional, Stabenow, Roland, additional, Luttmann, Sabine, additional, Nennecke, Alice, additional, Engel, Jutta, additional, Schubert-Fritschle, Gabriele, additional, Heidrich, Jan, additional, Holleczek, Bernd, additional, Jónasson, Jón Gunnlaugur, additional, Clough-Gorr, Kerri, additional, Comber, Harry, additional, Mazzoleni, Guido, additional, Giacomin, Adriano, additional, Sardo, Antonella Sutera, additional, Barchielli, Alessandro, additional, Serraino, Diego, additional, De Angelis, Roberta, additional, Mallone, Sandra, additional, Tavilla, Andrea, additional, Pierannunzio, Daniela, additional, Rossi, Silvia, additional, Santaquilani, Mariano, additional, Knijn, Arnold, additional, Pannozzo, Fabio, additional, Gennaro, Valerio, additional, Benfatto, Lucia, additional, Ricci, Paolo, additional, Autelitano, Mariangela, additional, Spagnoli, Gianbattista, additional, Fusco, Mario, additional, Usala, Mario, additional, Vitale, Francesco, additional, Michiara, Maria, additional, Tumino, Rosario, additional, Mangone, Lucia, additional, Falcini, Fabio, additional, Ferretti, Stefano, additional, Filiberti, Rosa Angela, additional, Marani, Enza, additional, Iannelli, Arturo, additional, Sensi, Flavio, additional, Piffer, Silvano, additional, Gentilini, Maria, additional, Madeddu, Anselmo, additional, Ziino, Antonio, additional, Maspero, Sergio, additional, Candela, Pina, additional, Stracci, Fabrizio, additional, Tagliabue, Giovanna, additional, Rugge, Massimo, additional, Trama, Annalisa, additional, Gatta, Gemma, additional, Botta, Laura, additional, Capocaccia, Riccardo, additional, Pildava, Santa, additional, Smailyte, Giedre, additional, Calleja, Neville, additional, Johannesen, Tom Børge, additional, Rachtan, Jadwiga, additional, Góźdź, Stanisław, additional, Błaszczyk, Jerzy, additional, Kępska, Kamila, additional, de Lacerda, Forjaz, additional, Bento, Maria José, additional, Miranda, Ana, additional, Diba, Chakameh Safaei, additional, Almar, Enrique, additional, Larrañaga, Nerea, additional, de Munain, Arantza Lopez, additional, Torrella-Ramos, Ana, additional, Díaz García, José María, additional, Marcos-Gragera, Rafael, additional, Sanchez, Maria Josè, additional, Navarro, Carmen, additional, Salmeron, Diego, additional, Moreno-Iribas, Conchi, additional, Galceran, Jaume, additional, Carulla, Marià, additional, Mousavi, Mohsen, additional, Bouchardy, Christine, additional, Ess, Silvia M., additional, Bordoni, Andrea, additional, Konzelmann, Isabelle, additional, Rashbass, Jem, additional, Gavin, Anna, additional, Brewster, David H., additional, Huws, Dyfed Wyn, additional, Visser, Otto, additional, Bielska-Lasota, Magdalena, additional, Primic-Zakelj, Maja, additional, Kunkler, Ian, additional, and Benhamou, Ellen, additional

Published
2019
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45. Treatment challenges in and outside a specialist network setting: Pancreatic neuroendocrine tumours

Author

Lykoudis, Panagis M., primary, Partelli, Stefano, additional, Muffatti, Francesca, additional, Caplin, Martyn, additional, Falconi, Massimo, additional, Fusai, Giuseppe K., additional, Hackl, Monika, additional, Van Eycken, Elizabeth, additional, Henau, Kris, additional, Dimitrova, Nadya, additional, Sekerija, Mario, additional, Dušek, Ladislav, additional, Mägi, Margit, additional, Malila, Nea, additional, Leinonen, Maarit, additional, Velten, Michel, additional, Troussard, Xavier, additional, Bouvier, Veronique, additional, Guizard, Anne-Valérie, additional, Bouvier, Anne-Marie, additional, Arveux, Patrick, additional, Maynadié, Marc, additional, Woronoff, Anne-Sophie, additional, Robaszkiewicz, Michel, additional, Baldi, Isabelle, additional, Monnereau, Alain, additional, Tretarre, Brigitte, additional, Colonna, Marc, additional, Molinié, Florence, additional, Bara, Simona, additional, Schvartz, Claire, additional, Lapôtre-Ledoux, Bénédicte, additional, Grosclaude, Pascale, additional, Stabenow, Roland, additional, Luttmann, Sabine, additional, Nennecke, Alice, additional, Engel, Jutta, additional, Schubert-Fritschle, Gabriele, additional, Heidrich, Jan, additional, Holleczek, Bernd, additional, Jónasson, Jón Gunnlaugur, additional, Clough-Gorr, Kerri, additional, Comber, Harry, additional, Mazzoleni, Guido, additional, Giacomin, Adriano, additional, Sardo, Antonella Sutera, additional, Barchielli, Alessandro, additional, Serraino, Diego, additional, De Angelis, Roberta, additional, Mallone, Sandra, additional, Tavilla, Andrea, additional, Pierannunzio, Daniela, additional, Rossi, Silvia, additional, Santaquilani, Mariano, additional, Knijn, Arnold, additional, Pannozzo, Fabio, additional, Gennaro, Valerio, additional, Benfatto, Lucia, additional, Ricci, Paolo, additional, Autelitano, Mariangela, additional, Spagnoli, Gianbattista, additional, Fusco, Mario, additional, Usala, Mario, additional, Vitale, Francesco, additional, Michiara, Maria, additional, Tumino, Rosario, additional, Mangone, Lucia, additional, Falcini, Fabio, additional, Ferretti, Stefano, additional, Filiberti, Rosa Angela, additional, Marani, Enza, additional, Iannelli, Arturo, additional, Sensi, Flavio, additional, Piffer, Silvano, additional, Gentilini, Maria, additional, Madeddu, Anselmo, additional, Ziino, Antonio, additional, Maspero, Sergio, additional, Candela, Pina, additional, Stracci, Fabrizio, additional, Tagliabue, Giovanna, additional, Rugge, Massimo, additional, Trama, Annalisa, additional, Gatta, Gemma, additional, Botta, Laura, additional, Capocaccia, Riccardo, additional, Pildava, Santa, additional, Smailyte, Giedre, additional, Calleja, Neville, additional, Johannesen, Tom Børge, additional, Rachtan, Jadwiga, additional, Góźdź, Stanisław, additional, Błaszczyk, Jerzy, additional, Kępska, Kamila, additional, de Lacerda, Gonçalo Forjaz, additional, Bento, Maria José, additional, Miranda, Ana, additional, Diba, Chakameh Safaei, additional, Almar, Enrique, additional, Larrañaga, Nerea, additional, de Munain, Arantza Lopez, additional, Torrella-Ramos, Ana, additional, Díaz García, José María, additional, Marcos-Gragera, Rafael, additional, Sanchez, Maria Josè, additional, Navarro, Carmen, additional, Salmeron, Diego, additional, Moreno-Iribas, Conchi, additional, Galceran, Jaume, additional, Carulla, Marià, additional, Mousavi, Mohsen, additional, Bouchardy, Christine, additional, Ess, Silvia M., additional, Bordoni, Andrea, additional, Konzelmann, Isabelle, additional, Rashbass, Jem, additional, Gavin, Anna, additional, Brewster, David H., additional, Huws, Dyfed Wyn, additional, Visser, Otto, additional, Bielska-Lasota, Magdalena, additional, Primic-Zakelj, Maja, additional, Kunkler, Ian, additional, and Benhamou, Ellen, additional

Published
2019
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46. Treatment challenges in and outside a network setting: Head and neck cancers

Author

Orlandi, Ester, primary, Alfieri, Salvatore, additional, Simon, Christian, additional, Trama, Annalisa, additional, Licitra, Lisa, additional, Hackl, Monika, additional, Eycken, Elizabeth Van, additional, Henau, Kris, additional, Dimitrova, Nadya, additional, Sekerija, Mario, additional, Dušek, Ladislav, additional, Mägi, Margit, additional, Malila, Nea, additional, Leinonen, Maarit, additional, Velten, Michel, additional, Troussard, Xavier, additional, Bouvier, Veronique, additional, Guizard, Anne-Valérie, additional, Bouvier, Anne-Marie, additional, Arveux, Patrick, additional, Maynadié, Marc, additional, Woronoff, Anne-Sophie, additional, Robaszkiewic, Michel, additional, Baldi, Isabelle, additional, Monnereau, Alain, additional, Tretarre, Brigitte, additional, Colonna, Marc, additional, Molinié, Florence, additional, Bara, Simona, additional, Schvartz, Claire, additional, Lapôtre-Ledoux, Bénédicte, additional, Grosclaude, Pascale, additional, Stabenow, Roland, additional, Luttmann, Sabine, additional, Nennecke, Alice, additional, Engel, Jutta, additional, Schubert-Fritschle, Gabriele, additional, Heidrich, Jan, additional, Holleczek, Bernd, additional, Jónasson, Jón Gunnlaugur, additional, Clough-Gorr, Kerri, additional, Comber, Harry, additional, Mazzoleni, Guido, additional, Giacomin, Adriano, additional, Sutera Sardo, Antonella, additional, Barchielli, Alessandr, additional, Serraino, Diego, additional, De Angelis, Roberta, additional, Mallone, Sandra, additional, Tavilla, Andrea, additional, Pierannunzio, Daniela, additional, Rossi, Silvia, additional, Santaquilani, Mariano, additional, Knijn, Arnold, additional, Pannozzo, Fabio, additional, Gennaro, Valerio, additional, Benfatto, Lucia, additional, Ricci, Paolo, additional, Autelitano, Mariangela, additional, Spagnoli, Gianbattista, additional, Fusco, Mario, additional, Usala, Mario, additional, Vitale, Francesco, additional, Michiara, Maria, additional, Tumino, Rosario, additional, Mangone, Lucia, additional, Falcini, Fabio, additional, Ferretti, Stefano, additional, Filiberti, Rosa Angela, additional, Marani, Enza, additional, Iannelli, Arturo, additional, Sensi, Flavio, additional, Piffer, Silvano, additional, Gentilini, Maria, additional, Madeddu, Anselmo, additional, Ziino, Antonio, additional, Maspero, Sergio, additional, Candela, Pina, additional, Stracci, Fabrizio, additional, Tagliabue, Giovanna, additional, Rugge, Massimo, additional, Gatta, Gemma, additional, Botta, Laura, additional, Capocaccia, Riccardo, additional, Pildava, Santa, additional, Smailyte, Giedre, additional, Calleja, Neville, additional, Johannesen, Tom Børge, additional, Rachtan, Jadwiga, additional, Góźdź, Stanisław, additional, Błaszczyk, Jerzy, additional, Kępska, Kamila, additional, de Lacerda, Gonçalo Forjaz, additional, Bento, Maria José, additional, Miranda, Ana, additional, Diba, Chakameh Safaei, additional, Almar, Enrique, additional, Larrañaga, Nerea, additional, de Munain, Arantza Lopez, additional, Torrella-Ramos, Ana, additional, Díaz García, José María, additional, Marcos-Gragera, Rafael, additional, Sanchez, Maria Josè, additional, Navarro, Carmen, additional, Salmeron, Diego, additional, Moreno-Iribas, Conchi, additional, Galceran, Jaume, additional, Carulla, Marià, additional, Mousavi, Mohsen, additional, Bouchardy, Christine, additional, Ess, Silvia M., additional, Bordoni, Andrea, additional, Konzelmann, Isabelle, additional, Rashbass, Jem, additional, Gavin, Anna, additional, Brewster, David H., additional, Huws, Dyfed Wyn, additional, Visser, Otto, additional, Bielska-Lasota, Magdalena, additional, Primic-Zakelj, Maja, additional, Kunkler, Ian, additional, and Benhamou, Ellen, additional

Published
2019
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47. Rare ovarian tumours: Epidemiology, treatment challenges in and outside a network setting

Author

Ray-Coquard, I., primary, Trama, AnnaLisa, additional, Seckl, M.J., additional, Fotopoulou, C., additional, Pautier, P., additional, Pignata, S., additional, Kristensen, G., additional, Mangili, G., additional, Falconer, H., additional, Massuger, L., additional, Sehouli, J., additional, Pujade-Lauraine, E., additional, Lorusso, D., additional, Amant, F., additional, Rokkones, E., additional, Vergote, I., additional, Ledermann, J.A., additional, Hackl, Monika, additional, Van Eycken, Elizabeth, additional, Henau, Kris, additional, Dimitrova, Nadya, additional, Sekerija, Mario, additional, Dušek, Ladislav, additional, Mägi, Margit, additional, Malila, Nea, additional, Leinonen, Maarit, additional, Velten, Michel, additional, Troussard, Xavier, additional, Bouvier, Veronique, additional, Guizard, Anne-Valérie, additional, Bouvier, Anne-Marie, additional, Arveux, Patrick, additional, Maynadié, Marc, additional, Woronoff, Anne-Sophie, additional, Robaszkiewicz, Michel, additional, Baldi, Isabelle, additional, Monnereau, Alain, additional, Tretarre, Brigitte, additional, Colonna, Marc, additional, Molinié, Florence, additional, Bara, Simona, additional, Schvartz, Claire, additional, Lapôtre-Ledoux, Bénédicte, additional, Grosclaude, Pascale, additional, Stabenow, Roland, additional, Luttmann, Sabine, additional, Nennecke, Alice, additional, Engel, Jutta, additional, Schubert-Fritschle, Gabriele, additional, Heidrich, Jan, additional, Holleczek, Bernd, additional, Jónasson, Jón Gunnlaugur, additional, Clough-Gorr, Kerri, additional, Comber, Harry, additional, Mazzoleni, Guido, additional, Giacomin, Adriano, additional, Sardo, Antonella Sutera, additional, Barchielli, Alessandro, additional, Serraino, Diego, additional, De Angelis, Roberta, additional, Mallone, Sandra, additional, Tavilla, Andrea, additional, Pierannunzio, Daniela, additional, Rossi, Silvia, additional, Santaquilani, Mariano, additional, Knijn, Arnold, additional, Pannozzo, Fabio, additional, Gennaro, Valerio, additional, Benfatto, Lucia, additional, Ricci, Paolo, additional, Autelitano, Mariangela, additional, Spagnoli, Gianbattista, additional, Fusco, Mario, additional, Usala, Mario, additional, Vitale, Francesco, additional, Michiara, Maria, additional, Tumino, Rosario, additional, Mangone, Lucia, additional, Falcini, Fabio, additional, Ferretti, Stefano, additional, Filiberti, Rosa Angela, additional, Marani, Enza, additional, Iannelli, Arturo, additional, Sensi, Flavio, additional, Piffer, Silvano, additional, Gentilini, Maria, additional, Madeddu, Anselmo, additional, Ziino, Antonio, additional, Maspero, Sergio, additional, Candela, Pina, additional, Stracci, Fabrizio, additional, Tagliabue, Giovanna, additional, Rugge, Massimo, additional, Trama, Annalisa, additional, Gatta, Gemma, additional, Botta, Laura, additional, Capocaccia, Riccardo, additional, Pildava, Santa, additional, Smailyte, Giedre, additional, Calleja, Neville, additional, Johannesen, Tom Børge, additional, Rachtan, Jadwiga, additional, Góźdź, Stanisław, additional, Błaszczyk, Jerzy, additional, Kępska, Kamila, additional, de Lacerda, Gonçalo Forjaz, additional, José Bento, Maria, additional, Miranda, Ana, additional, Safaei Diba, Chakameh, additional, Almar, Enrique, additional, Larrañaga, Nerea, additional, de Munain, Arantza Lopez, additional, Torrella-Ramos, Ana, additional, Díaz García, José María, additional, Marcos-Gragera, Rafael, additional, Josè Sanchez, Maria, additional, Navarro, Carmen, additional, Salmeron, Diego, additional, Moreno-Iribas, Conchi, additional, Galceran, Jaume, additional, Carulla, Marià, additional, Mousavi, Mohsen, additional, Bouchardy, Christine, additional, Ess, Silvia M., additional, Bordoni, Andrea, additional, Konzelmann, Isabelle, additional, Rashbass, Jem, additional, Gavin, Anna, additional, Brewster, David H., additional, Huws, Dyfed Wyn, additional, Visser, Otto, additional, Bielska-Lasota, Magdalena, additional, Primic-Zakelj, Maja, additional, Kunkler, Ian, additional, and Benhamou, Ellen, additional

Published
2019
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48. Testicular germ-cell tumours and penile squamous cell carcinoma: Appropriate management makes the difference

Author

Nicolai, Nicola, primary, Biasoni, Davide, additional, Catanzaro, Mario A., additional, Colecchia, Maurizio, additional, Trama, Annalisa, additional, Hackl, Monika, additional, Eycken, Elizabeth Van, additional, Henau, Kris, additional, Dimitrova, Nadya, additional, Sekerija, Mario, additional, Dušek, Ladislav, additional, Mägi, Margit, additional, Malila, Nea, additional, Leinonen, Maarit, additional, Velten, Michel, additional, Troussard, Xavier, additional, Bouvier, Veronique, additional, Guizard, Anne-Valérie, additional, Bouvier, Anne-Marie, additional, Arveux, Patrick, additional, Maynadié, Marc, additional, Woronoff, Anne-Sophie, additional, Robaszkiewic, Michel, additional, Baldi, Isabelle, additional, Monnereau, Alain, additional, Tretarre, Brigitte, additional, Colonna, Marc, additional, Molinié, Florence, additional, Bara, Simona, additional, Schvartz, Claire, additional, Lapôtre-Ledoux, Bénédicte, additional, Grosclaude, Pascale, additional, Stabenow, Roland, additional, Luttmann, Sabine, additional, Nennecke, Alice, additional, Engel, Jutta, additional, Schubert-Fritschle, Gabriele, additional, Heidrich, Jan, additional, Holleczek, Bernd, additional, Jónasson, Jón Gunnlaugur, additional, Clough-Gorr, Kerri, additional, Comber, Harry, additional, Mazzoleni, Guido, additional, Giacomin, Adriano, additional, Sutera Sardo, Antonella, additional, Barchielli, Alessandr, additional, Serraino, Diego, additional, De Angelis, Roberta, additional, Mallone, Sandra, additional, Tavilla, Andrea, additional, Pierannunzio, Daniela, additional, Rossi, Silvia, additional, Santaquilani, Mariano, additional, Knijn, Arnold, additional, Pannozzo, Fabio, additional, Gennaro, Valerio, additional, Benfatto, Lucia, additional, Ricci, Paolo, additional, Autelitano, Mariangela, additional, Spagnoli, Gianbattista, additional, Fusco, Mario, additional, Usala, Mario, additional, Vitale, Francesco, additional, Michiara, Maria, additional, Tumino, Rosario, additional, Mangone, Lucia, additional, Falcini, Fabio, additional, Ferretti, Stefano, additional, Filiberti, Rosa Angela, additional, Marani, Enza, additional, Iannelli, Arturo, additional, Sensi, Flavio, additional, Piffer, Silvano, additional, Gentilini, Maria, additional, Madeddu, Anselmo, additional, Ziino, Antonio, additional, Maspero, Sergio, additional, Candela, Pina, additional, Stracci, Fabrizio, additional, Tagliabue, Giovanna, additional, Rugge, Massimo, additional, Gatta, Gemma, additional, Botta, Laura, additional, Capocaccia, Riccardo, additional, Pildava, Santa, additional, Smailyte, Giedre, additional, Calleja, Neville, additional, Johannesen, Tom Børge, additional, Rachtan, Jadwiga, additional, Góźdź, Stanisław, additional, Błaszczyk, Jerzy, additional, Kępska, Kamila, additional, de Lacerda, Gonçalo Forjaz, additional, Bento, Maria José, additional, Miranda, Ana, additional, Diba, Chakameh Safaei, additional, Almar, Enrique, additional, Larrañaga, Nerea, additional, de Munain, Arantza Lopez, additional, Torrella-Ramos, Ana, additional, Díaz García, José María, additional, Marcos-Gragera, Rafael, additional, Sanchez, Maria Josè, additional, Navarro, Carmen, additional, Salmeron, Diego, additional, Moreno-Iribas, Conchi, additional, Galceran, Jaume, additional, Carulla, Marià, additional, Mousavi, Mohsen, additional, Bouchardy, Christine, additional, M. Ess, Silvia, additional, Bordoni, Andrea, additional, Konzelmann, Isabelle, additional, Rashbass, Jem, additional, Gavin, Anna, additional, Brewster, David H., additional, Huws, Dyfed Wyn, additional, Visser, Otto, additional, Bielska-Lasota, Magdalena, additional, Primic-Zakelj, Maja, additional, Kunkler, Ian, additional, and Benhamou, Ellen, additional

Published
2019
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49. Mesothelioma and thymic tumors: Treatment challenges in (outside) a network setting

Author

Imbimbo, Martina, primary, Maury, Jean-Michel, additional, Garassino, Marina, additional, Girard, Nicolas, additional, Hackl, Monika, additional, Eycken, Elizabeth Van, additional, Henau, Kris, additional, Dimitrova, Nadya, additional, Sekerija, Mario, additional, Dušek, Ladislav, additional, Mägi, Margit, additional, Malila, Nea, additional, Leinonen, Maarit, additional, Velten, Michel, additional, Troussard, Xavier, additional, Bouvier, Veronique, additional, Guizard, Anne-Valérie, additional, Bouvier, Anne-Marie, additional, Arveux, Patrick, additional, Maynadié, Marc, additional, Woronoff, Anne-Sophie, additional, Robaszkiewicz, Michel, additional, Baldi, Isabelle, additional, Monnereau, Alain, additional, Tretarre, Brigitte, additional, Colonna, Marc, additional, Molinié, Florence, additional, Bara, Simona, additional, Schvartz, Claire, additional, Lapôtre-Ledoux, Bénédicte, additional, Grosclaude, Pascale, additional, Stabenow, Roland, additional, Luttmann, Sabine, additional, Nennecke, Alice, additional, Engel, Jutta, additional, Schubert-Fritschle, Gabriele, additional, Heidrich, Jan, additional, Holleczek, Bernd, additional, Jónasson, Jón Gunnlaugur, additional, Clough-Gorr, Kerri, additional, Comber, Harry, additional, Mazzoleni, Guido, additional, Giacomin, Adriano, additional, Sardo, Antonella Sutera, additional, Barchielli, Alessandro, additional, Serraino, Diego, additional, De Angelis, Roberta, additional, Mallone, Sandra, additional, Tavilla, Andrea, additional, Pierannunzio, Daniela, additional, Rossi, Silvia, additional, Santaquilani, Mariano, additional, Knijn, Arnold, additional, Pannozzo, Fabio, additional, Gennaro, Valerio, additional, Benfatto, Lucia, additional, Ricci, Paolo, additional, Autelitano, Mariangela, additional, Spagnoli, Gianbattista, additional, Fusco, Mario, additional, Usala, Mario, additional, Vitale, Francesco, additional, Michiara, Maria, additional, Tumino, Rosario, additional, Mangone, Lucia, additional, Falcini, Fabio, additional, Ferretti, Stefano, additional, Angela Filiberti, Rosa, additional, Marani, Enza, additional, Iannelli, Arturo, additional, Sensi, Flavio, additional, Piffer, Silvano, additional, Gentilini, Maria, additional, Madeddu, Anselmo, additional, Ziino, Antonio, additional, Maspero, Sergio, additional, Candela, Pina, additional, Stracci, Fabrizio, additional, Tagliabue, Giovanna, additional, Rugge, Massimo, additional, Trama, Annalisa, additional, Gatta, Gemma, additional, Botta, Laura, additional, Capocaccia, Riccardo, additional, Pildava, Santa, additional, Smailyte, Giedre, additional, Calleja, Neville, additional, Johannesen, Tom Børge, additional, Rachtan, Jadwiga, additional, Góźdź, Stanisław, additional, Błaszczyk, Jerzy, additional, Kępska, Kamila, additional, de Lacerda, Gonçalo Forjaz, additional, Bento, Maria José, additional, Miranda, Ana, additional, Diba, Chakameh Safaei, additional, Almar, Enrique, additional, Larrañaga, Nerea, additional, de Munain, Arantza Lopez, additional, Torrella-Ramos, Ana, additional, Díaz García, José María, additional, Marcos-Gragera, Rafael, additional, Sanchez, Maria Josè, additional, Navarro, Carmen, additional, Salmeron, Diego, additional, Moreno-Iribas, Conchi, additional, Galceran, Jaume, additional, Carulla, Marià, additional, Mousavi, Mohsen, additional, Bouchardy, Christine, additional, Ess, Silvia M., additional, Bordoni, Andrea, additional, Konzelmann, Isabelle, additional, Rashbass, Jem, additional, Gavin, Anna, additional, Brewster, David H., additional, Huws, Dyfed Wyn, additional, Visser, Otto, additional, Bielska-Lasota, Magdalena, additional, Primic-Zakelj, Maja, additional, Kunkler, Ian, additional, and Benhamou, Ellen, additional

Published
2019
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50. BRCA Challenge: BRCA Exchange as a global resource for variants in BRCA1 and BRCA2.

Author

Cline, Melissa, Cline, Melissa, Liao, Rachel, Parsons, Michael, Paten, Benedict, Alquaddoomi, Faisal, Antoniou, Antonis, Baxter, Samantha, Brody, Larry, Cook-Deegan, Robert, Coffin, Amy, Couch, Fergus, Craft, Brian, Currie, Robert, Dlott, Chloe, Dolman, Lena, den Dunnen, Johan, Dyke, Stephanie, Domchek, Susan, Easton, Douglas, Fischmann, Zachary, Foulkes, William, Garber, Judy, Goldgar, David, Goldman, Mary, Goodhand, Peter, Harrison, Steven, Kato, Kazuto, Knoppers, Bartha, Markello, Charles, Nussbaum, Robert, Offit, Kenneth, Plon, Sharon, Rashbass, Jem, Rehm, Heidi, Robson, Mark, Rubinstein, Wendy, Stoppa-Lyonnet, Dominique, Tavtigian, Sean, Thorogood, Adrian, Zhang, Can, Zimmermann, Marc, Burn, John, Chanock, Stephen, Rätsch, Gunnar, Spurdle, Amanda, Haussler, David, Cline, Melissa, Cline, Melissa, Liao, Rachel, Parsons, Michael, Paten, Benedict, Alquaddoomi, Faisal, Antoniou, Antonis, Baxter, Samantha, Brody, Larry, Cook-Deegan, Robert, Coffin, Amy, Couch, Fergus, Craft, Brian, Currie, Robert, Dlott, Chloe, Dolman, Lena, den Dunnen, Johan, Dyke, Stephanie, Domchek, Susan, Easton, Douglas, Fischmann, Zachary, Foulkes, William, Garber, Judy, Goldgar, David, Goldman, Mary, Goodhand, Peter, Harrison, Steven, Kato, Kazuto, Knoppers, Bartha, Markello, Charles, Nussbaum, Robert, Offit, Kenneth, Plon, Sharon, Rashbass, Jem, Rehm, Heidi, Robson, Mark, Rubinstein, Wendy, Stoppa-Lyonnet, Dominique, Tavtigian, Sean, Thorogood, Adrian, Zhang, Can, Zimmermann, Marc, Burn, John, Chanock, Stephen, Rätsch, Gunnar, Spurdle, Amanda, and Haussler, David

Abstract

The BRCA Challenge is a long-term data-sharing project initiated within the Global Alliance for Genomics and Health (GA4GH) to aggregate BRCA1 and BRCA2 data to support highly collaborative research activities. Its goal is to generate an informed and current understanding of the impact of genetic variation on cancer risk across the iconic cancer predisposition genes, BRCA1 and BRCA2. Initially, reported variants in BRCA1 and BRCA2 available from public databases were integrated into a single, newly created site, www.brcaexchange.org. The purpose of the BRCA Exchange is to provide the community with a reliable and easily accessible record of variants interpreted for a high-penetrance phenotype. More than 20,000 variants have been aggregated, three times the number found in the next-largest public database at the projects outset, of which approximately 7,250 have expert classifications. The data set is based on shared information from existing clinical databases-Breast Cancer Information Core (BIC), ClinVar, and the Leiden Open Variation Database (LOVD)-as well as population databases, all linked to a single point of access. The BRCA Challenge has brought together the existing international Evidence-based Network for the Interpretation of Germline Mutant Alleles (ENIGMA) consortium expert panel, along with expert clinicians, diagnosticians, researchers, and database providers, all with a common goal of advancing our understanding of BRCA1 and BRCA2 variation. Ongoing work includes direct contact with national centers with access to BRCA1 and BRCA2 diagnostic data to encourage data sharing, development of methods suitable for extraction of genetic variation at the level of individual laboratory reports, and engagement with participant communities to enable a more comprehensive understanding of the clinical significance of genetic variation in BRCA1 and BRCA2.

Published
2018

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