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4 results on '"Rasha M Hasanin"'

1. Assessment of vitamin D status and vitamin D receptor polymorphism in Egyptian children with Type 1 diabetes

Author

Eman A. Mostafa, Maha M.A. Abo Hashish, Nagwa Abdallah Ismail, Hasanin M. Hasanin, Rasha M. Hasanin, Aliaa Ahmed Wahby, Ingy Ashmawy, Shereen Hamdy Abd El Aziz, and Mai Magdy Abdel Wahed

Subjects
Type 1 diabetes mellitus (T1DM), Vitamin D receptor (VDR), Polymorphism, Children, Biotechnology, TP248.13-248.65, Genetics, QH426-470
Abstract

Background: The endocrine system of vitamin D regulates about 3 % of the human genome. Vitamin D exerts its actions via a nuclear vitamin D receptor (VDR) which in turn regulates insulin secretion from the pancreas. VDR gene polymorphisms could have an impact on how autoimmune illnesses like Type 1 diabetes mellitus (T1DM) develop. We aimed to explore the relation between T1DM and VDR gene polymorphisms in Egyptian diabetic children and their siblings. Methods: Enzyme-linked immunosorbent assay was used to quantify 25(OH) vitamin D in the study, which had 179 participants (group 1 = 85 diabetic children, group 2 = 57 siblings of the patients, group 3 = 37 healthy controls). Real-time polymerase chain reaction (RT-PCR) was used to analyze the genotyping of the VDR gene polymorphisms Apa-I (rs7975232), Fok-I (rs2228570), Taq-I (rs731236) and Bsm-I (rs1544410). Results: The mean serum 25(OH) vitamin D levels was significantly lower in T1DM patients (14.99 ± 9.24 ng/mL) and siblings (16.31 ± 7.96 ng/mL) compared to the controls (19.48 ± 7.42 ng/mL) (p = 0.031). The genotypes distribution of VDR Fok-I (rs2228570) and Bsm-I (rs1544410) polymorphisms showed a significant difference between patients, siblings and controls as P = 0.001 and 0.026 respectively, while the VDR ApaI and TaqI polymorphisms did not. FokI-A allele frequency was significantly lower in T1DM patients and siblings than in controls (p

Published
2024
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2. Assessment of seasonal variation on neonatal sepsis

Author

Mohamed A. Abdel Mawla, Eman A. Mostafa, Rasha M. Hasanin, and Mohab M. Salah

Subjects
Seasonal variation, Neonatal sepsis, Morbidity, Bacteremia, Science
Abstract

Abstract Background Neonatal sepsis is the major cause of morbidity and mortality in neonates. Frequency of bacterial sepsis is affected by seasonal variations. This study was done to rule out the effects of seasonal variation on neonatal sepsis and to determine isolated bacterial agents and their antibiotic sensitivity profile. Results This cross-sectional study included100 neonates with suspected sepsis, and conducted during summer and winter seasons. High frequencies of neonatal morbidities were observed like poor feeding (98%), Jaundice (82%), pallor (76%), respiratory distress (66%) and convulsions (64%) in winter, whereas fever (40%) and edema (12%) in summer. Statically significant correlation was found between the seasonal variations and different symptomatic expression of bacteremia like jaundice, respiratory distress, convulsions and poor feeding (p value

Published
2021
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3. Hearing assessment in Egyptian children with chronic renal failure on regular hemodialysis and renal transplantation children

Author

Fatina I. Fadel, Gamal Abdel Naser Yamamah, Rasha M. Hasanin, Eman A. Mostafa, Shaimaa Abdalaleem Abdalgeleel, Mohab M. Salah, Rasha E. E. Galal, and Mohamed A. Abdel Mawla

Subjects
Hearing, Renal Dialysis, Nephrology, Humans, Kidney Failure, Chronic, Egypt, Hepacivirus, Hematology, Renal Insufficiency, Chronic, Child, Hearing Loss, Hepatitis C, Kidney Transplantation
Abstract

Hearing impairment is frequent in patients with end-stage renal disease (ESRD). We aimed to assess the prevalence of hearing impairment in children on regular hemodialysis and renal transplantation.Transient-evoked otoacoustic emissions (TEOAEs) has been done for 80 children on regular hemodialysis and 40 with renal transplant.In hemodialysis group, TEOAEs showed that 53.8% children had hearing affection, it was significantly related to dialysis duration, dialysis adequacy, vascular access infection, hepatitis C virus (HCV) infection, and ototoxic drugs (p = 0.001, 0.037, 0.011, 0.004, 0.030, 0.007, and 0.044, respectively). In renal transplant group hearing impairment was 25%. There was significant relation with period of dialysis before transplantation and biopsy proved rejection (p = 0.008,0.001, respectively).Hearing impairment is a common finding in ESRD patients. Thus audiological assessment must be done in these patients.

Published
2021
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4. Primary hyperoxaluria type 1 in children: Clinical classification, renal replacement therapy, and outcome in a single centre experience

Author

Amr Mohamed Salem, Mohamed A. Abdel Mawla, Doaa M. Salah, Fatina I. Fadel, Khalda Amr, Hoda Abdalla Ahmed, Mohamed Gamal Fathallah, Rasha M Hasanin, and Magd A. Kotb

Subjects
Male, Pediatrics, medicine.medical_specialty, medicine.medical_treatment, 030232 urology & nephrology, 030204 cardiovascular system & hematology, Peritoneal dialysis, Primary hyperoxaluria, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Renal replacement therapy, Age of Onset, Child, Obstructive uropathy, Dialysis, business.industry, Infant, Hematology, medicine.disease, Causality, Renal Replacement Therapy, Nephrology, Child, Preschool, Hyperoxaluria, Primary, Kidney Failure, Chronic, Egypt, Female, Hemodialysis, Age of onset, business, Cohort study
Abstract

Introduction Primary hyperoxaluria type 1 (PH1) is a rare disease that is challenged by the overproduced oxalate and commonly presented with radiopaque renal stones or obstructive uropathy. This study aimed to report clinical presentations, renal replacement therapy (RRT) and outcome of PH1 in end stage kidney disease (ESKD) children. Methods This is an observational cohort study. Data of 22 patients with ESKD due to PH1 were analyzed at Pediatric Nephrology Unit, Faculty of Medicine Cairo University. Results Infantile onset patients (n=10) had worst renal outcome (80% with ESRD at presentation, p=0.019) and worse patient outcome (mortality 40%, p=0.016) than juvenile (n=9) and late onset (PH1 n=3) patients. RRT modalities include peritoneal dialysis (PD) in 7 (31.8%), hemodialysis (HD) in 11(50 %) and, combined liver kidney transplantation (CLKT) in 4 (18.2%) patients. Infectious complications were encountered in 42.8% of PD patients. Better HD adequacy was observed with frequent HD (n=6) and/or HD via arteriovenous fistula (AVF) than with infrequent dialysis (n=5) and/or via central venous line (CVL) (P =0.0001 & 0.0047 respectively). Morbidity and mortality (infection related) rates of the whole cohort were 63.6% and 31.8% respectively. Conclusions Clinical presentation of PH1 varies according to the age of onset (infantile onset being the most aggressive form). Aggressive HD (better through AVF) is needed to achieve acceptable HD adequacy, PD was challenged by infection. Infection found to be the main cause of mortality even after successful CLKT. This article is protected by copyright. All rights reserved.

Published
2021

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