16 results on '"Rasel Ahmed Khan"'
Search Results
2. Propolis: An update on its chemistry and pharmacological applications
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Rajib Hossain, Cristina Quispe, Rasel Ahmed Khan, Abu Saim Mohammad Saikat, Pranta Ray, Damira Ongalbek, Balakyz Yeskaliyeva, Divya Jain, Antonella Smeriglio, Domenico Trombetta, Roghayeh Kiani, Farzad Kobarfard, Naheed Mojgani, Parvaneh Saffarian, Seyed Abdulmajid Ayatollahi, Chandan Sarkar, Mohammad Torequl Islam, Dılhun Keriman, Arserim Uçar, Miquel Martorell, Antoni Sureda, Gianfranco Pintus, Monica Butnariu, Javad Sharifi-Rad, and William C. Cho
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Anticancer ,Antioxidant ,Anti-inflammatory ,Bee glue ,Bioactive compounds ,Food preservative ,Other systems of medicine ,RZ201-999 - Abstract
Abstract Propolis, a resinous substance produced by honeybees from various plant sources, has been used for thousands of years in traditional medicine for several purposes all over the world. The precise composition of propolis varies according to plant source, seasons harvesting, geography, type of bee flora, climate changes, and honeybee species at the site of collection. This apiary product has broad clinical applications such as antioxidant, anti-inflammatory, antimicrobial, anticancer, analgesic, antidepressant, and anxiolytic as well asimmunomodulatory effects. It is also well known from traditional uses in treating purulent disorders, improving the wound healing, and alleviating many of the related discomforts. Even if its use was already widespread since ancient times, after the First and Second World War, it has grown even more as well as the studies to identify its chemical and pharmacological features, allowing to discriminate the qualities of propolis in terms of the chemical profile and relative biological activity based on the geographic place of origin. Recently, several in vitro and in vivo studies have been carried out and new insights into the pharmaceutical prospects of this bee product in the management of different disorders, have been highlighted. Specifically, the available literature confirms the efficacy of propolis and its bioactive compounds in the reduction of cancer progression, inhibition of bacterial and viral infections as well as mitigation of parasitic-related symptoms, paving the way to the use of propolis as an alternative approach to improve the human health. However, a more conscious use of propolis in terms of standardized extracts as well as new clinical studies are needed to substantiate these health claims.
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- 2022
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3. Anxiolytic-like Effect of Quercetin Possibly through GABA Receptor Interaction Pathway: In Vivo and In Silico Studies
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Md. Shahazul Islam, Rajib Hossain, Taukir Ahmed, Md. Mizanur Rahaman, Khattab Al-Khafaji, Rasel Ahmed Khan, Chandan Sarkar, Mehedi Hasan Bappi, Edlane Martins de Andrade, Isaac Moura Araújo, Henrique Douglas Melo Coutinho, Grażyna Kowalska, Radosław Kowalski, Muhammad Asif Hanif, and Muhammad Torequl Islam
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anxiety ,quercetin ,GABAergic system ,in vivo study ,molecular docking ,Organic chemistry ,QD241-441 - Abstract
Scientific evidence suggests that quercetin (QUR) has anxiolytic-like effects in experimental animals. However, the mechanism of action responsible for its anxiolytic-like effects is yet to be discovered. The goal of this research is to assess QUR’s anxiolytic effects in mouse models to explicate the possible mechanism of action. After acute intraperitoneal (i.p.) treatment with QUR at a dose of 50 mg/kg (i.p.), behavioral models of open-field, hole board, swing box, and light–dark tests were performed. QUR was combined with a GABAergic agonist (diazepam) and/or antagonist (flumazenil) group. Furthermore, in silico analysis was also conducted to observe the interaction of QUR and GABA (α5), GABA (β1), and GABA (β2) receptors. In the experimental animal model, QUR had an anxiolytic-like effect. QUR, when combined with diazepam (2 mg/kg, i.p.), drastically potentiated an anxiolytic effect of diazepam. QUR is a more highly competitive ligand for the benzodiazepine recognition site that can displace flumazenil (2.5 mg/kg, i.p.). In all the test models, QUR acted similar to diazepam, with enhanced effects of the standard anxiolytic drug, which were reversed by pre-treatment with flumazenil. QUR showed the best interaction with the GABA (α5) receptor compared to the GABA (β1) and GABA (β2) receptors. In conclusion, QUR may exert an anxiolytic-like effect on mice, probably through the GABA-receptor-interacting pathway.
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- 2022
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4. Diterpenes/Diterpenoids and Their Derivatives as Potential Bioactive Leads against Dengue Virus: A Computational and Network Pharmacology Study
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Rasel Ahmed Khan, Rajib Hossain, Abolghasem Siyadatpanah, Khattab Al-Khafaji, Abul Bashar Ripon Khalipha, Dipta Dey, Umma Hafsa Asha, Partha Biswas, Abu Saim Mohammad Saikat, Hadi Ahmadi Chenari, Polrat Wilairatana, and Muhammad Torequl Islam
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Aedes aegypti ,dengue virus ,diterpene ,molecular docking ,NS5 ,NS1 ,Organic chemistry ,QD241-441 - Abstract
Dengue fever is a dangerous infectious endemic disease that affects over 100 nations worldwide, from Africa to the Western Pacific, and is caused by the dengue virus, which is transmitted to humans by an insect bite of Aedes aegypti. Millions of citizens have died as a result of dengue fever and dengue hemorrhagic fever across the globe. Envelope (E), serine protease (NS3), RNA-directed RNA polymerase (NS5), and non-structural protein 1 (NS1) are mostly required for cell proliferation and survival. Some of the diterpenoids and their derivatives produced by nature possess anti-dengue viral properties. The goal of the computational study was to scrutinize the effectiveness of diterpenoids and their derivatives against dengue viral proteins through in silico study. Methods: molecular docking was performed to analyze the binding affinity of compounds against four viral proteins: the envelope (E) protein, the NS1 protein, the NS3 protein, and the NS5 protein. Results: among the selected drug candidates, triptolide, stevioside, alepterolic acid, sphaeropsidin A, methyl dodovisate A, andrographolide, caesalacetal, and pyrimethamine have demonstrated moderate to good binding affinities (−8.0 to −9.4 kcal/mol) toward the selected proteins: E protein, NS3, NS5, and NS1 whereas pyrimethamine exerts −7.5, −6.3, −7.8, and −6.6 kcal/mol with viral proteins, respectively. Interestingly, the binding affinities of these lead compounds were better than those of an FDA-approved anti-viral medication (pyrimethamine), which is underused in dengue fever. Conclusion: we can conclude that diterpenoids can be considered as a possible anti-dengue medication option. However, in vivo investigation is recommended to back up the conclusions of this study.
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- 2021
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5. Quercetin and/or Ascorbic Acid Modulatory Effect on Phenobarbital-Induced Sleeping Mice Possibly through GABAA and GABAB Receptor Interaction Pathway
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Rajib Hossain, Khattab Al-Khafaji, Rasel Ahmed Khan, Chandan Sarkar, Md. Shahazul Islam, Dipta Dey, Divya Jain, Farhana Faria, Rukaya Akbor, Olubunmi Atolani, Sónia M. R. Oliveira, Abolghasem Siyadatpanah, Maria de Lourdes Pereira, and Muhammad Torequl Islam
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ascorbic acid ,quercetin ,Mus musculus ,stimulatory-like activity ,GABA receptor ,molecular docking ,Medicine ,Pharmacy and materia medica ,RS1-441 - Abstract
Depressive disorder is a recurrent illness that affects large numbers of the general population worldwide. In recent years, the goal of depression treatment has moved from symptomatic response to that of full remission. However, treatment-resistant depression is a major challenge in the treatment of depression or depression-related disorders. Consensus opinion, therefore, suggests that effective combined aggressive initial treatment is the most appropriate strategy. This study aimed to evaluate the effects of quercetin (QUR) and/or ascorbic acid (AA) on Phenobarbital-induced sleeping mice. QUR (50 mg/kg) and/or AA (25 mg/kg) with or without intraperitoneally pre-treated with GABA receptor agonist (diazepam: 2 mg/kg, i.p.) or antagonist (Flumazenil: 2.5 mg/kg, i.p.) to underscore the effects, as well as the possible involvement of the GABA receptor in the modulatory action of QUR and AA in sleeping mice. Additionally, an in silico study was undertaken to predict the involvement of GABA receptors in the sleep mechanism. Findings suggest that the pretreatment of QUR and AA modulated the onset and duration of action of the standard drugs in experimental animals. The acute administration of QUR and/or AA significantly (p < 0.05) reversed the DZP-mediated onset of action and slightly reversed the duration of sleep time in comparison to the vehicle (control) group. A further combination of QUR or AA with the FLU resulted in an enhancement of the onset of action while reducing the duration of action, suggesting a FLU-like effect on the test animals. In in silico studies, AA and QUR showed good to moderate binding affinities with GABAA and GABAB receptors. Both QUR and AA produced a stimulatory-like effect on mice, possibly through the GABAA and GABAB receptor interaction pathways. Further studies are necessary to verify this activity and clarify the exact mechanism of action(s) involved.
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- 2021
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6. Amentoflavone derivatives against SARS-CoV-2 main protease (MPRO): An in silico study
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Rajib Hossain, Shafi Mahmud, Abul Bashar Ripon Khalipha, Abu Saim Mohammad Saikat, Dipta Dey, Rasel Ahmed Khan, Abdur Rauf, Abdur Abdul Wadood, Humaria Rafique, Sami Bawazeer, Anees Ahmed Khalil, Zainab M. Almarhoon, Yahia N. Mabkhot, Khalid J. Alzahrani, Muhammad Torequl Islam, Khalaf F. Alsharif, and Haroon Khan
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Inorganic Chemistry ,Organic Chemistry ,Materials Chemistry - Abstract
Globally, novel coronavirus (nCoV19) outbreak is a great concern to humanity owing to the unavailability of effective medication or vaccine to date. Therefore, the development of drugs having anti-COVID-19 potential is a need of time. In this milieu, in-silico studies have proven to be rapid, inexpensive and effective as compared to other experimental studies. Evidently, natural products have shown significant potential in drug development to curtail different ailments, which have opened a new horizon in the screening of anti-COVID-19 agents. In this study, in-silico analysis were performed on derivatives of amentoflavone (4′, 4′′′-Dimethylamentoflavone, 4′′′, 7-Di-O-Methylamentoflavone, 4′′′′′′-methylamentoflavone, 4′-Monomethylamentoflavone, 7,4′-Dimethylamentoflavone, 7′-O-Methylamentoflavone, 7-O-methylamentoflavone, Heveaflavone, kayaflavone, and Sciadopitysin) and FDA approved anti-viral drug (camostatmesylate). All the derivatives of amentoflavone and FDA-approved anti-viral drugs were docked against SARS-CoV2 main protease (MPRO). The ten derivatives of amentoflavone showed strong interactions with the MPRO protein. In all cases, derivatives of amentoflavone showed good interaction with the targeted protein and better binding/docking score (–9.0351, –8.8566, –8.8509, –8.7746, –8.6192, –8.2537, –8.0876, –7.9501, –7.6429, and –7.6248 respectively) than FDA approved anti-viral drug. Therefore, derivatives of amentoflavone may be potent leads in drug discovery to combat HCoVs, such as SARS-CoV2. Moreover, to support the outcomes of this study further in-vivo investigations are required.
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- 2023
7. Phytochemical Constituents and Antidiabetic Features of Black Cumin (Nigella sativa L.)
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Rajib Hossain, Rasel Ahmed Khan, Nabarun Mukhopadhyay, Divya Jain, and Muhammad Torequl Islam
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- 2023
8. Natural Compounds or Their Derivatives against Breast Cancer: A Computational Study
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Rajib Hossain, Pranta Ray, Chandan Sarkar, Md. Shahazul Islam, Rasel Ahmed Khan, Abul Bashar Ripon Khalipha, Muhammad Torequl Islam, William C. Cho, Miquel Martorell, Javad Sharifi-Rad, Monica Butnariu, Almagul Umbetova, and Daniela Calina
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BRCA2 Protein ,Curcumin ,Article Subject ,General Immunology and Microbiology ,BRCA1 Protein ,Genes, BRCA1 ,Breast Neoplasms ,General Medicine ,General Biochemistry, Genetics and Molecular Biology ,Citrinin ,Molecular Docking Simulation ,Humans ,Female ,Genetic Predisposition to Disease ,Fluorouracil ,Apigenin ,skin and connective tissue diseases ,Germ-Line Mutation - Abstract
Background. Breast cancer is one of the most common types of cancer diagnosed and the second leading cause of death among women. Breast cancer susceptibility proteins of type 1 and 2 are human tumor suppressor genes. Genetic variations/mutations in these two genes lead to overexpression of human breast tumor suppressor genes (e.g., BRCA1, BRCA2), which triggers uncontrolled duplication of cells in humans. In addition, multidrug resistance protein 1 (MDR1), an important cell membrane protein that pumps many foreign substances from cells, is also responsible for developing resistance to cancer chemotherapy. Aim of the Study. The aim of this study was to analyze some natural compounds or their derivatives as part of the development of strong inhibitors for breast cancer. Methodology. Molecular docking studies were performed using compounds known in the literature to be effective against BRCA1 and BRCA2 and MDR1, with positive control being 5-fluorouracil, an antineoplastic drug as a positive control. Results. The binding affinity of the compounds was analyzed, and it was observed that they had a better binding affinity for the target proteins than the standard drug 5-fluorouracil. Among the compounds analyzed, α-hederin, andrographolide, apigenin, asiatic acid, auricular acid, sinularin, curcumin, citrinin, hispolon, nerol, phytol, retinol palmitate, and sclareol showed the best binding affinity energy to the BRCA1, BRCA2, and MDR1 proteins, respectively. Conclusions. α-Hederin, andrographolide, apigenin, asiatic acid, auricular acid, hispolon, sclareol, curcumin, citrinin, and sinularin or their derivatives can be a good source of anticancer agents in breast cancer.
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- 2022
9. Natural-Derived Molecules as a Potential Adjuvant in Chemotherapy: Normal Cell Protectors and Cancer Cell Sensitizers
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Abu Saim Mohammad Saikat, Mohammad S. Mubarak, Muhammad Torequl Islam, Rasel Ahmed Khan, Divya Jain, and Rajib Hossain
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Flavonoids ,Pharmacology ,Naringenin ,Cancer Research ,business.industry ,Cancer ,Antineoplastic Agents ,Eriodictyol ,medicine.disease ,Antioxidants ,Oxidative Stress ,chemistry.chemical_compound ,chemistry ,Neoplasms ,Cancer cell ,Humans ,Molecular Medicine ,Medicine ,Myricetin ,Chrysin ,business ,Naringin ,Fisetin - Abstract
Background: Cancer is a global threat to humans and a leading cause of death worldwide. Cancer treatment includes, among other things, the use of chemotherapeutic agents, compounds that are vital for treating and preventing cancer. However, chemotherapeutic agents produce oxidative stress along with other side effects that would affect the human body. Objective: The aim of the study was to reduce the oxidative stress of chemotherapeutic agents in cancer and normal cells by naturally derived compounds with anti-cancer properties, and protect normal cells from the oxidation process. Therefore, the need to develop more potent chemotherapeutics with fewer side effects has become increasingly important. Method: Recent literature dealing with the antioxidant and anticancer activities of the naturally derived compounds, morin, myricetin, malvidin, naringin, eriodictyol, isovitexin, daidzein, naringenin, chrysin, and fisetin, has been surveyed and examined in this review. For this, data were gathered from different search engines, including Google Scholar, ScienceDirect, PubMed, Scopus, Web of Science, Scopus, and Scifinder, among others. Additionally, several patent offices such as WIPO, CIPO, and USPTO were consulted to obtain published articles related to these compounds. Result: Numerous plants contain flavonoids and polyphenolic compounds, such as morin, myricetin, malvidin, naringin, eriodictyol, isovitexin, daidzein, naringenin, chrysin, and fisetin, which exhibit antioxidant, anti-inflammatory, and anti-carcinogenic actions via several mechanisms. These compounds act as sensitizers of cancer cells and protector of healthy cells. Moreover, these compounds can reduce oxidative stress, which is accelerated by chemotherapeutics, and exhibit a potent anticancer effect on cancer cells. Conclusions: Based on these findings, more research is recommended to explore and evaluate such flavonoids and polyphenolic compounds.
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- 2022
10. In Silico Screening of Natural Products as Potential Inhibitors of SARS-CoV-2 Using Molecular Docking Simulation
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Rajib Hossain, Chandan Sarkar, Shardar Mohammad Hafiz Hassan, Rasel Ahmed Khan, Mohammad Arman, Pranta Ray, Muhammad Torequl Islam, Sevgi Durna Daştan, Javad Sharifi-Rad, Zainab M. Almarhoon, Miquel Martorell, William N. Setzer, and Daniela Calina
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Biological Products ,SARS-CoV-2 ,nonstructural proteins ,structural proteins ,molecular docking ,General Medicine ,Antiviral Agents ,COVID-19 Drug Treatment ,Molecular Docking Simulation ,Mice ,Complementary and alternative medicine ,Animals ,Humans ,Original Article ,Pharmacology (medical) ,natural products-derived anti-SARS-CoV-2 candidates - Abstract
Objective To explore potential natural products against severe acute respiratory syndrome coronavirus (SARS-CoV-2) via the study of structural and non-structural proteins of human coronaviruses. Methods In this study, we performed an in-silico survey of 25 potential natural compounds acting against SARS-CoV-2. Molecular docking studies were carried out using compounds against 3-chymotrypsin-like protease (3CLPRO), papain-like protease (PLPRO), RNA-dependent RNA polymerase (RdRp), non-structural protein (nsp), human angiotensin converting enzyme 2 receptor (hACE2R), spike glycoprotein (S protein), abelson murine leukemia viral oncogene homolog 1 (ABL1), calcineurin-nuclear factor of activated T-cells (NFAT) and transmembrane protease serine 2. Results Among the screened compounds, amentoflavone showed the best binding affinity with the 3CLPRO, RdRp, nsp13, nsp15, hACE2R. ABL1 and calcineurin-NFAT; berbamine with hACE2R and ABL1; cepharanthine with nsp10, nsp14, nsp16, S protein and ABL1; glucogallin with nsp15; and papyriflavonol A with PLPRO protein. Other good interacting compounds were juglanin, betulinic acid, betulonic acid, broussooflavan A, tomentin A, B and E, 7-methoxycryptopleurine, aloe emodin, quercetin, tanshinone I, tylophorine and furruginol, which also showed excellent binding affinity towards a number of target proteins. Most of these compounds showed better binding affinities towards the target proteins than the standard drugs used in this study. Conclusion Natural products or their derivatives may be one of the potential targets to fight against SARS-CoV-2. Electronic Supplementary Material Supplementary materials (Appendixes 1–6) are available in the online version of this article at DOI: 10.1007/s11655-021-3504-5
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- 2021
11. Doxorubicin hydrochloride liposome and albumin-bound paclitaxel in cancer: a nanotechnology perspective
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Divya Jain, Muhammad Torequl Islam, Rasel Ahmed Khan, Aakanksha Bharati, Obinna Chukwuemeka Godfrey, Shiwali Bisht, Pracheta Janmeda, and Rajib Hossain
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business.industry ,Cancer ,02 engineering and technology ,Pharmacology ,021001 nanoscience & nanotechnology ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Albumin bound paclitaxel ,030220 oncology & carcinogenesis ,medicine ,0210 nano-technology ,business ,Doxorubicin hydrochloride liposome - Abstract
Nanoparticles (1-100 nanometres in size), products of nanotechnology, offer a modern way to transport anti-cancer drugs by acting as transporters of drugs into tumor cells, hence quenching tumor cell proliferation. Such nanoparticles may be formulated to bind to the tumor cell membrane or inhibit specific reactions of tumor biosynthetic pathway by gene repression, or directly bind to the active sites of essential enzymes in the biosynthetic pathway. Consequently, drugs are completely delivered to the desired cancerous cells without system interference. Liposomal doxorubicin and albumin-bound paclitaxel are two examples of nanotechnologically developed drugs for treating cancer. Modern knowledge of nanotechnology opens up new opportunities for innovative research on cancer therapies and administration and helps minimize harm to healthy cells. This review focuses on the doses and routes of administration of these chemotherapeutic agents used in treating cancers.
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- 2021
12. Computer-aided Evaluation of Anti-SARS-CoV-2 (3-chymotrypsin-like Protease and Transmembrane Protease Serine 2 Inhibitors) Activity of Cepharanthine: An In silico Approach
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Rasel Ahmed Khan, Khalid Hakeem, and Pracheta Janmeda
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Molecular Medicine ,Molecular Biology ,Biochemistry ,Biotechnology - Abstract
3-chymotrypsin-like protease (3CLPRO) is found in severe acute respiratory syndrome coronavirus (SARS CoV)-2, and transmembrane protease serine 2 (TMPRSS-2) in humans, both of them have a role in viral attachment and proliferation. 3CLPRO and TMPRSS-2 are the most vital target for the discovery of an anti-corona virus. One efficient approach used to screen potential active compounds against specific target proteins, such as 3CLPRO and TMPRSS-2, is molecular docking. Cepharanthine (CEP) exhibits antiviral activity in SARS-CoV at 9.5 µg/mL IC50 level. This study aims to perform an in silico study on CEP against non-structural SARS-CoV-2 3CLPRO and host transmembrane protease serine 2 protein. Molecular docking studies were carried out using compounds against 3CLPRO and TMPRSS-2 proteins through Swiss model, Uniport, PROCHECK, Swiss PDB viewer, PyMol, and PyRx computerized software. CEP displayed strong binding interactions -8.5 and -7.4 Kcal/mol with the 3CLPRO, and TMPRSS-2 proteins. In all cases, CEP showed better binding affinities than FDA-approved anti-corona virus drug (Camostat mesylate, CAM) is currently underused in COVID-19. CEP may be one of the potentials leads to fighting against SARS-CoV-2. Further in vivo studies should be required to support the findings of this study.
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- 2021
13. Diterpenes/Diterpenoids and Their Derivatives as Potential Bioactive Leads against Dengue Virus: A Computational and Network Pharmacology Study
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Abolghasem Siyadatpanah, Dipta Dey, Khattab Al-Khafaji, Umma Hafsa Asha, Muhammad Torequl Islam, Rajib Hossain, Partha S. Biswas, Rasel Ahmed Khan, Abu Saim Mohammad Saikat, Polrat Wilairatana, Abul Bashar Ripon Khalipha, and Hadi Ahmadi Chenari
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Aedes aegypti ,NS5 ,Andrographolide ,viruses ,Phytochemicals ,NS1 ,Pharmaceutical Science ,Organic chemistry ,Viral Nonstructural Proteins ,Dengue virus ,medicine.disease_cause ,diterpene ,Analytical Chemistry ,Dengue fever ,Dengue ,chemistry.chemical_compound ,QD241-441 ,Viral Envelope Proteins ,Drug Discovery ,biology ,Serine Endopeptidases ,virus diseases ,Molecular Docking Simulation ,Chemistry (miscellaneous) ,Molecular Medicine ,Diterpenes ,RNA Helicases ,Protein Binding ,medicine.drug ,In silico ,Antiviral Agents ,Article ,medicine ,Humans ,Computer Simulation ,Physical and Theoretical Chemistry ,Serine protease ,NS3 ,Binding Sites ,dengue virus ,molecular docking ,biology.organism_classification ,medicine.disease ,Virology ,Pyrimethamine ,chemistry ,Drug Design ,biology.protein - Abstract
Dengue fever is a dangerous infectious endemic disease that affects over 100 nations worldwide, from Africa to the Western Pacific, and is caused by the dengue virus, which is transmitted to humans by an insect bite of Aedes aegypti. Millions of citizens have died as a result of dengue fever and dengue hemorrhagic fever across the globe. Envelope (E), serine protease (NS3), RNA-directed RNA polymerase (NS5), and non-structural protein 1 (NS1) are mostly required for cell proliferation and survival. Some of the diterpenoids and their derivatives produced by nature possess anti-dengue viral properties. The goal of the computational study was to scrutinize the effectiveness of diterpenoids and their derivatives against dengue viral proteins through in silico study. Methods: molecular docking was performed to analyze the binding affinity of compounds against four viral proteins: the envelope (E) protein, the NS1 protein, the NS3 protein, and the NS5 protein. Results: among the selected drug candidates, triptolide, stevioside, alepterolic acid, sphaeropsidin A, methyl dodovisate A, andrographolide, caesalacetal, and pyrimethamine have demonstrated moderate to good binding affinities (−8.0 to −9.4 kcal/mol) toward the selected proteins: E protein, NS3, NS5, and NS1 whereas pyrimethamine exerts −7.5, −6.3, −7.8, and −6.6 kcal/mol with viral proteins, respectively. Interestingly, the binding affinities of these lead compounds were better than those of an FDA-approved anti-viral medication (pyrimethamine), which is underused in dengue fever. Conclusion: we can conclude that diterpenoids can be considered as a possible anti-dengue medication option. However, in vivo investigation is recommended to back up the conclusions of this study.
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- 2021
14. Ethnomedicinal Use, Phytochemistry, and Pharmacology of Xylocarpus granatum J. Koenig
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Cristina Quispe, Rasel Ahmed Khan, Hafiz Ansar Rasul Suleria, Manoj Kumar, Yasaman Taheri, Javad Sharifi-Rad, Anka Trajkovska Petkoska, Sevgi Durna Daştan, Pracheta Janmeda, Divya Jain, Miquel Martorell, Rajib Hossain, Dipta Dey, Muhammad Torequl Islam, and Fen Fakültesi
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Mangrove plants ,Phytochemistry ,biology ,Traditional medicine ,Review Article ,Antimicrobial ,biology.organism_classification ,Limonoid ,Other systems of medicine ,Complementary and alternative medicine ,Phytochemical ,Xylocarpus granatum ,Phragmalin ,medicine ,Medicinal herbs ,RZ201-999 ,medicine.drug - Abstract
The mangrove plants are the potential sources of foods and remedies for people living in the forests and nearby communities. Xylocarpus granatum J. Koenig is traditionally used to treat various diseases including diarrhea, cholera, dysentery, fever, malaria, and viral infections, among others. To summarize critically the taxonomy, ethnomedicinal, phytochemistry, and pharmacological activities of X. granatum, information was collected from different databases. An up-to-date search (till June 2020) was carried out with the help of various scientific web resources from databases such as PubMed, Science Direct, Google Scholar, and various patent offices (e.g., WIPO, CIPO, and USPTO) using the keywords “Xylocarpus granatum” and then paired with ethnomedicinal use and phytochemical, phytochemistry, and pharmacological activity (in vitro, ex vivo, and in vivo studies). Findings revealed that seeds, fruits, stem bark, leaf, and twigs of X. granatum exhibited a wide range of key phytochemicals including limonoids, phragmalin, limonoid-based alkaloids, mexicanolides, protolimonoids, flavonols, and lactones. The plant possessed potent antioxidant, anticancer, antidiabetic, antimicrobial, antimalarial, antifeedant, and neuroprotective activities. No clinical studies have been reported in the databases. Ethnomedicinal assessment indicated the application of X. granatum in various fields of medical science specially to treat various human ailments, and this was attributed to the presence of enormous alkaloids as confirmed by pharmacological studies. However, to understand the mechanism of action in-depth studies are required. In view of these findings, more research is necessary to explore and characterize the chemical compounds and toxicological aspects of this medicinal mangrove plant. Overall, it can be stated that X. granatum may be one of the hopeful medicinal herbs for the treatment of various diseases in human beings.
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- 2021
15. Anticancer effects of acteoside: Mechanistic insights and therapeutic status
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Rasel Ahmed Khan, Rajib Hossain, Pranta Roy, Divya Jain, Abu Saim Mohammad Saikat, Anik Prasad Roy Shuvo, Muhammad Akram, Walaa Fikry Elbossaty, Ishaq N. Khan, Sakshi Painuli, Prabhakar Semwal, Abdur Rauf, Muhammad Torequl Islam, and Haroon Khan
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Pharmacology ,Glucosides ,Phenols ,Antineoplastic Agents ,Apoptosis - Abstract
Cancer, the uncontrolled proliferation and metastasis of abnormal cells, is a major public health issue worldwide. To date, several natural compounds have been reported with their efficacy in the treatment of different types of cancer. Chemotherapeutic agents are used in cancer treatment and prevention, among other aspects. Acteoside is a phenylethanoid glycoside, first isolated from Verbascum sinuatum, which has demonstrated multiple effects, including antioxidant, anti-epileptic, neuroprotective, anti-inflammatory, antifungal, antihypertensive, and anti-leishmanial properties. This review gathered, analyzed, and summarized the literature on acteoside and its anticancer properties. All the available information about this compound and its role in different types of cancer was collected using different scientific search engines, including PubMed, Scopus, Springer Link, Wiley Online, Web of Science, Scifinder, ScienceDirect, and Google Scholar. Acteoside is found in a variety of plants and has been shown to have anticancer activity in many experimental models through oxidative stress, apoptosis, anti-angiogenesis, anti-invasion, anti-metastasis, synergism with other agents, and anti-proliferative effects through modulation of several pathways. In conclusion, acteoside exhibited potent anticancer activity against different cancer cell lines through modulating several cancer signaling pathways in different non- and pre-clinical experimental models and thus could be a strong candidate for further clinical studies.
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- 2022
16. Quercetin and/or Ascorbic Acid Modulatory Effect on Phenobarbital-Induced Sleeping Mice Possibly through GABAA and GABAB Receptor Interaction Pathway
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Maria de Lourdes Pereira, Rasel Ahmed Khan, Khattab Al-Khafaji, Rukaya Akbor, Rajib Hossain, Divya Jain, Sónia M R Oliveira, Dipta Dey, Chandan Kumar Sarkar, Farhana Faria, Shahazul Islam, Abolghasem Siyadatpanah, Muhammad Torequl Islam, and Olubunmi Atolani
- Subjects
0301 basic medicine ,Mus musculus ,Pharmaceutical Science ,Pharmacology ,GABAB receptor ,quercetin ,03 medical and health sciences ,Pharmacy and materia medica ,0302 clinical medicine ,GABA receptor ,Drug Discovery ,Medicine ,business.industry ,GABAA receptor ,stimulatory-like activity ,molecular docking ,Ascorbic acid ,GABA receptor agonist ,RS1-441 ,030104 developmental biology ,Mechanism of action ,Flumazenil ,Molecular Medicine ,ascorbic acid ,Onset of action ,medicine.symptom ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Background: Depressive disorder is a recurrent illness that affects large numbers of the general population worldwide. In recent years, the goal of depression treatment has moved from symptomatic response to that of full remission. However, treatment-resistant depression is a major challenge in the treatment of depression or depression-related disorders. Consensus opinion, therefore, suggests that effective combined aggressive initial treatment is the most appropriate strategy. Objectives: This study aimed to evaluate the effects of quercetin (QUR) and/or ascorbic acid (AA) on Phenobarbital-induced sleeping mice. Methods: QUR (50 mg/kg) and/or AA (25 mg/kg) with or without intraperitoneally pre-treated with GABA receptor agonist (diazepam: 2 mg/kg, i.p.) or antagonist (Flumazenil: 2.5 mg/kg, i.p.) to underscore the effects, as well as the possible involvement of the GABA receptor in the modulatory action of QUR and AA in sleeping mice. Additionally, an in silico study was undertaken to predict the involvement of GABA receptors in the sleep mechanism. Results: Findings suggest that the pretreatment of QUR and AA modulated the onset and duration of action of the standard drugs in experimental animals. The acute administration of QUR and/or AA significantly (p <, 0.05) reversed the DZP-mediated onset of action and slightly reversed the duration of sleep time in comparison to the vehicle (control) group. A further combination of QUR or AA with the FLU resulted in an enhancement of the onset of action while reducing the duration of action, suggesting a FLU-like effect on the test animals. In in silico studies, AA and QUR showed good to moderate binding affinities with GABAA and GABAB receptors. Conclusions: Both QUR and AA produced a stimulatory-like effect on mice, possibly through the GABAA and GABAB receptor interaction pathways. Further studies are necessary to verify this activity and clarify the exact mechanism of action(s) involved.
- Published
- 2021
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