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192 results on '"Rasche, Dirk"'

18. Sweets for my sweet: modulation of the limbic system drives salience for sweet foods after deep brain stimulation in Parkinson’s disease

Author

Steinhardt, Julia, primary, Hanssen, Henrike, additional, Heldmann, Marcus, additional, Neumann, Alexander, additional, Münchau, Alexander, additional, Schramm, Peter, additional, Rasche, Dirk, additional, Saryyeva, Assel, additional, Büntjen, Lars, additional, Voges, Jürgen, additional, Tronnier, Volker, additional, Krauss, Joachim K., additional, Münte, Thomas F., additional, and Brüggemann, Norbert, additional

Published
2021
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26. Additional file 1 of Efficacy of different spinal cord stimulation paradigms for the treatment of chronic neuropathic pain (PARS-trial): study protocol for a double-blinded, randomized, and placebo-controlled crossover trial

Author

Ahmadi, Rezvan, Campos, Benito, Hajiabadi, Mohammad Mehdi, Doerr-Harim, Colette, Tenckhoff, Solveig, Rasche, Dirk, Unterberg, Andreas, Vesper, Jan, Bruckner, Tom, and Tronnier, Volker

Abstract

Additional file 1. SPIRIT 2013 Checklist: Recommended items to address in a clinical trial protocol and related documents.

Published
2021
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27. Intrathecal pain management with ziconotide: Time for consensus?

Author

Matis, Georgios, De Negri, Pasquale, Dupoiron, Denis, Likar, Rudolf, Zuidema, Xander, Rasche, Dirk, Matis, Georgios, De Negri, Pasquale, Dupoiron, Denis, Likar, Rudolf, Zuidema, Xander, and Rasche, Dirk

Abstract

This article summarizes recommendations made by six pain specialists who discussed the rationale for ziconotide intrathecal analgesia (ITA) and the requirement for evidence-based guidance on its use, from a European perspective. Riemser Pharma GmbH (Greifswald, Germany), which holds the European marketing authorization for ziconotide, hosted the meeting. The group agreed that ITA is under-used in Europe, adding that ziconotide ITA has potential to be a first-line alternative to morphine; both are already first-line options in the USA. Ziconotide ITA (initiated using a low-dose, slow-titration approach) is suitable for many patients with noncanceror cancer-related chronic refractory pain and no history of psychosis. Adopting ziconotide as first-line ITA could reduce opioid usage in these patient populations. The group advocated a risk-reduction strategy for all candidate patients, including compulsory prescreening for neuropsychosis, and requested US-European alignment of the licensed starting dose for ziconotide: the low-and-slow approach practiced in the USA has a better tolerability profile than the fixed high starting dose licensed in Europe. Of note, an update to the European Summary of Product Characteristics is anticipated in early 2021. The group acknowledged that the Polyanalgesic Consensus Conference (PACC) treatment algorithms for ziconotide ITA provide useful guidance, but recommendations tailored specifically for European settings are required. Before a consensus process can formally begin, the group called for additional European prospective studies to investigate ziconotide in low-and-slow dosing strategies, in different patient settings. Such data would enable European guidance to have the most appropriate evidence at its core.

Published
2021

35. Sweets for my sweet: modulation of the limbic system drives salience for sweet foods after deep brain stimulation in Parkinson's disease.

Author

Steinhardt, Julia, Hanssen, Henrike, Heldmann, Marcus, Neumann, Alexander, Münchau, Alexander, Schramm, Peter, Rasche, Dirk, Saryyeva, Assel, Büntjen, Lars, Voges, Jürgen, Tronnier, Volker, Krauss, Joachim K., Münte, Thomas F., and Brüggemann, Norbert

Subjects
SUBTHALAMIC nucleus, BRAIN stimulation, DEEP brain stimulation, PARKINSON'S disease, LIMBIC system, SALIENCE network, WEIGHT gain, PARKINSON'S disease treatment, RESEARCH, MOTIVATION (Psychology), RESEARCH methodology, MAGNETIC resonance imaging, EVALUATION research, COMPARATIVE studies, REWARD (Psychology), FOOD
Abstract

Background: An increase in body weight is observed in the majority of patients with Parkinson's disease (PD) who undergo deep brain stimulation (DBS) of the subthalamic nucleus (STN) although the mechanisms are unclear.Objectives: To identify the stimulation-dependent effects on reward-associated and attention-associated neural networks and to determine whether these alterations in functional connectivity are associated with the local impact of DBS on different STN parcellations.Methods: We acquired functional task-related MRI data from 21 patients with PD during active and inactive STN DBS and 19 controls while performing a food viewing paradigm. Electrode placement in the STN was localised using a state-of-the-art approach. Based on the 3D model, the local impact of STN DBS was estimated.Results: STN DBS resulted in a mean improvement of motor function of 22.6%±15.5% (on medication) and an increase of body weight of ~4 kg within 2 years of stimulation. DBS of the limbic proportion of the STN was associated with body weight gain and an increased functional connectivity within the salience network and at the same time with a decreased activity within the reward-related network in the context of sweet food images.Conclusions: Our findings indicate increased selective attention for high-caloric foods and a sweet food seeking-like behaviour after DBS particularly when the limbic proportion of the STN was stimulated. [ABSTRACT FROM AUTHOR]

Published
2022
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39. Stimulation des Hinterwurzelganglions - klinische Erfahrungen und ein Patientenkollektiv eines Zentrums

Author

Rasche, Dirk and Tronnier, Volker

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: In the past decade a lot of evidence is reported for the importance of the dorsal root ganglion (DRG) for transmission, modulation and filtering of peripheral pain signals to the spinal cord. The clinical experiences and results of a prospective patient cohort of a single neuromodulation [for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Published
2019

42. Association of Pallidal Neurostimulation and Outcome Predictors With X-linked Dystonia Parkinsonism

Author

Brüggemann, Norbert, primary, Domingo, Aloysius, additional, Rasche, Dirk, additional, Moll, Christian K. E., additional, Rosales, Raymond L., additional, Jamora, Roland Dominic G., additional, Hanssen, Henrike, additional, Münchau, Alexander, additional, Graf, Julia, additional, Weissbach, Anne, additional, Tadic, Vera, additional, Diesta, Cid C., additional, Volkmann, Jens, additional, Kühn, Andrea, additional, Münte, Thomas F., additional, Tronnier, Volker, additional, and Klein, Christine, additional

Published
2019
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43. Spinal cord stimulation and MRI-compatibility

Author

Rasche, Dirk and Tronnier, Volker

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: Spinal cord stimulation (SCS) is an invasive treatment option for various chronic neuropathic pain syndromes. An estimated number of 1500 implants per year are performed in Germany. Because of the expanding indications and increasing number of magnetic resonance imaging-examinations it is[for full text, please go to the a.m. URL], 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS)

Published
2017
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44. Basal ganglia and cerebellar pathology in X-linked dystonia-parkinsonism

Author

Hanssen, Henrike, primary, Heldmann, Marcus, additional, Prasuhn, Jannik, additional, Tronnier, Volker, additional, Rasche, Dirk, additional, Diesta, Cid C, additional, Domingo, Aloysius, additional, Rosales, Raymond L, additional, Jamora, Roland D, additional, Klein, Christine, additional, Münte, Thomas F, additional, and Brüggemann, Norbert, additional

Published
2018
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49. Textbook of Neuromodulation : Principles, Methods and Clinical Applications / edited by Helena Knotkova, Dirk Rasche.

Author

Knotkova, Helena. editor., Rasche, Dirk. editor., SpringerLink (Online service), Knotkova, Helena. editor., Rasche, Dirk. editor., and SpringerLink (Online service)

Abstract

Textbook of Neuromodulation encompasses the basic principles, methods and current clinical applications of invasive and non-invasive neuromodulation. Neurophysiological systems are reviewed along with the basic principles of neuroplasticity that constitutes the rationale for neuromodulation in human medicine. The overview of the neuromodulatory techniques is provided with special regard to safety and specific patient populations. Comprehensive and authored by leaders in the field, this resource presents the clinical potential, significance and practical applications of this innovative treatment approach.

Published
2015

50. Imaging Sensory Effects of Occipital Nerve Stimulation: A New Computer-based Method in Neuromodulation

Author

Goebel, Anna, Goebel, Carl H., Heinze, Axel, Heinze-Kuhn, Katja, Petersen, Inga, Meinecke, Christoph, Clasen, Svenja, Niederberger, Uwe, Rasche, Dirk, Mehdorn, Hubertus M., Goebel, Hartmut, Goebel, Anna, Goebel, Carl H., Heinze, Axel, Heinze-Kuhn, Katja, Petersen, Inga, Meinecke, Christoph, Clasen, Svenja, Niederberger, Uwe, Rasche, Dirk, Mehdorn, Hubertus M., and Goebel, Hartmut

Abstract

Background: Within the last years, occipital nerve stimulation (ONS) has proven to be an important method in the treatment of severe therapy-resistant neurological pain disorders. The correspondence between lead placement as well as possible stimulation parameters and the resulting stimulation effects remains unclear. Objective: The method aims to directly relate the neuromodulatory mechanisms with the clinical treatment results, to achieve insight in the mode of action of neuromodulation, to identify the most effective stimulation sets and to optimize individual treatment effects. Methods: We describe a new computer-based imaging method for mapping the spatial, cognitive and affective sensory effects of ONS. The procedure allows a quantitative and qualitative analysis of the relationship between lead positioning, the stimulation settings as well as the sensory and clinical stimulation effects. Conclusion: A regular mapping of stimulation and sensory parameters allows a coordinated monitoring. The stimulation results can be reviewed and compared with regards to clinical effectiveness. (C) 2015 Elsevier Inc. All rights reserved.

Published
2015

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