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Schools are a fundamental context for processes of promotion and generation of resilience, since they focus not only on aspects of academic development, but also of personal and social development. Resilience in the teacher has a dual function. On the one hand, as resilient professionals, teachers can foster the development of resilience in their students; on the other hand, teaching resilience facilitates their own personal and professional well-being. Despite research highlighting the benefits of resilience in education, there is scarce research focused on assessing resilience in teachers. Thus, the aim of this paper is to analyze the psychometric properties of the Spanish version of Connor and Davidson’s 10-item resilience scale (CD-RISC 10©) in a sample of 290 teachers. A confirmatory factorial analysis (CFA) is performed, which shows that the 10 items on the CD-RISC 10© Resilience Scale form a one-dimensional structure, with high reliability, McDonald’s Omega coefficient (! = 0.80) and Cronbach’s alpha coefficient (α = 0.87). The results obtained in this work support the use of the scale for the assessment of resilience in teachers of Infant, Primary and Special Education, which is considered very useful, not only to know their degree of resilience, but also to assess the effectiveness of training programs.

Background: This paper presents a description of the development and psychometric properties of a self-report instrument for the assessment of sexual behaviour and concerns of people with mild intellectual disabilities (SEBECOMID-S). Methods and procedures: The study included 281 people with mild intellectual disabilities. The psychometric properties were examined through exploratory factorial analysis, descriptive statistics, and reliability indices. Results: The exploratory factor analyses offered a structure with three factors: concern about the appropriateness of their sexual behaviour, sexual practices performed, and safe sex practices. The model presents an excellent fit (χ2 /df = 1.10, RMSEA = 0.019, CFI = 0.997, TLI = 0.995, and SRMR = 0.065). General test reliability was good (α = 0.77, Ω = 0.76). Conclusions: SEBECOMID-S is a valid and reliable tool to obtain objective information about the sexual behaviour and concerns of people with mild intellectual disabilities. The use of this instrument will make it possible to adjust their training to their real experiences, making it more effective. Funding for open access charge: CRUE-Universitat Jaume I

Para la superficie de las tierras agrícolas de México se determinaron las áreas con diferentes grados de aptitud para maíz, sorgo y trigo, todos bajo temporal, para las condiciones actuales y con escenarios de cambio climático estimados con los modelos GFDL, HAGDEM y REA; para los RCP de 4.5 y 8.5 W m-2. La proporción de las tierras agrícolas con algún grado de aptitud para las condiciones actuales es la siguiente: maíz 81.59%, sorgo 61.54% y trigo 26.95%. De las variables climáticas que determinan la falta de aptitud en el maíz y el trigo en las áreas agrícolas es principalmente la temperatura media anual sola o en combinación con la precipitación, en el sorgo es principalmente la precipitación media anual sola o en combinación con la temperatura media anual. Para los escenarios de cambio climático, con excepción del sorgo, los otros dos cultivos disminuyen de forma considerable la proporción de la superficie de las tierras agrícolas con algún grado de aptitud para estos. El incremento de la temperatura media anual a valores mayores del umbral en que se desarrollan los cultivos de maíz y trigo es la principal causa de perdida de aptitud. La determinación del cambio del grado de aptitud asociada al cambio climático puede usarse para desarrollar políticas públicas para atender la problemática de disminución o perdida de la capacidad de desarrollo de los cultivos.

La neurociencia educativa es un campo de investigación interdisciplinar que busca traducir los resultados de la investigación en neurociencia, para comprender los efectos de la educación en el cerebro y mejorar las prácticas de enseñanza-aprendizaje en la escuela. En este campo, en las últimas dos décadas, se ha generado un creciente interés científico en el estudio del desarrollo de las funciones ejecutivas (FE) durante el periodo escolar. La evidencia de que la intervención y el entrenamiento de estos procesos puede generar repercusiones positivas en el rendimiento académico (RA) ha estimulado una variada producción de información en los últimos diez años. Esta revisión pretende aunar aquellas investigaciones en las que se vinculan las variables de RA y FE, realizadas entre los años 2000 y 2018, en las bases de datos Proquest, Pubmed y Dialnet, con el propósito de conocer el estado actual de este campo del conocimiento. Para esta revisión se han seguido las directrices de la declaración PRISMA. Los resultados muestran cuáles son los autores más prolíficos en este campo, así como los tipos de investigación más utilizados, los años y países más productivos y los principales hallazgos en este campo. A la luz de estos resultados, se concluye que hay una escasez de estudios teóricos, lo que hace necesario establecer un modelo teórico unificador e incrementar los estudios experimentales planteados desde distintos diseños de investigación, que aporten diferentes perspectivas al conocimiento de este ámbito. Educational neuroscience is an interdisciplinary field of research that seeks to translate the results of neuroscience research, to understand the effects of education on the brain and to improve teaching-learning practices at school. In this field, in the last two decades there has been a growing scientific interest in the study of the development of executive functions (EF) during the school period. The evidence that the intervention and training of these processes can generate positive repercussions on academic performance (AP), has stimulated a varied production of information in the last ten years. This review aims to combine those researches in which the AP and EF variables, made between 2000 and 2018, are linked in the Proquest, Pubmed and Dialnet databases, with the purpose of knowing the current state of this field of knowledge. The guidelines of the PRISMA Declaration have been followed for this review. The results show which are the most prolific authors in this field, as well as the most used types of research, the most productive years and countries and the main findings in this field. In the light of these results, it is concluded that there is a shortage of theoretical studies, which makes it necessary to establish a unifying theoretical model, and to increase the experimental studies raised from different research designs, which contribute different perspectives to the knowledge of this field.

Most cases of cyberbullying occur in secondary education, which is the stage where many cyberbullying programs are focused. This situation has given rise to the design, implementation and evaluation of a cyberbullying prevention program integrated within the primary education curriculum, based on a needs analysis carried out with 55 teachers and 156 parents. The objective of this study is to evaluate the effect of the program on a sample of 159 students of primary education, following a quasi-experimental pre-post design with two groups, including training for teachers and parents. Significant differences have been obtained in the following dimensions: emotional self-awareness, problem solving, responsible use, digital teaching tutoring and family supervision. It is concluded that the program is effective, as it develops the personal and technological skills assessed in the students, and has a positive impact on the tutoring and supervision of their teachers and parents. El mayor número de casos de ciberacoso sucede en la etapa de Educación Secundaria, donde se centran gran parte de programas que trabajan ciberacoso. Esta situación lleva al diseño, implantación y evaluación de un programa de prevención de ciberacoso integrado en el curriculum escolar de Educación Primaria, partiendo de un análisis de necesidades realizado con 55 docentes y 156 padres y madres. El objetivo del presente estudio es evaluar el efecto del programa en una muestra de 159 estudiantes de Educación Primaria, siguiendo un diseño cuasi-experimental, pre-post con dos grupos, incluyendo formación para docentes, padres y madres. Se han obtenido diferencias significativas en las dimensiones autoconciencia emocional, resolución de problemas, uso responsable, tutorización digital docente y supervisión familiar. Se concluye que el programa es efectivo, desarrollando en el alumnado las habilidades personales y tecnológicas evaluadas, y repercutiendo positivamente en la tutorización y supervisión de sus docentes y progenitores.

La diversidad sexual tiende a considerarse una cuestión que afecta principalmente a personas jóvenes por lo que los estudios centrados en la vivencia de una orientación sexual minoritaria en personas mayores son muy escasos. El objetivo de este estudio ha sido analizar el grado de coincidencia entre la orientación sexual autodefinida, el objeto de deseo y las personas con las que se han tenido relaciones sexuales. En este estudio han participado 244 personas (47,5% hombres y 52,5% mujeres) de entre 55 y 80 años heterogéneos en cuanto al nivel socioeconómico, grado académico y situación laboral. Todos ellos han cumplimentado un cuestionario sobre orientación sexual y aspectos como religión o actividad sexual. Los resultados muestran que el 13% (8,6% hombres, 16,4% mujeres) no se sienten atraídos exclusivamente por el sexo opuesto y el 6% reconoce haber mantenido prácticas homoeróticas (3,5% hombres y 7,9% mujeres). En los hombres la coincidencia entre autodefinición y objeto de deseo es mayor que en las mujeres. Se discute la necesidad de analizar de modo cualitativo en estudios futuros variables relacionadas con la historia sexual y la trayectoria vital por su posible influencia en cuanto a la exploración y/o aceptación de opciones sexuales no mayoritarias.

Resumen El mayor numero de casos de ciberacoso sucede en la etapa de Educacion Secundaria, donde se centran gran parte de los programas que trabajan ciberacoso. Esta situacion lleva al diseno, implantacion y evaluacion de un programa de prevencion de ciberacoso integrado en el curriculum escolar de Educacion Primaria, partiendo de un analisis de necesidades realizado con 55 docentes y 156 padres y madres. El objetivo del presente estudio es evaluar el efecto del programa en una muestra de 159 estudiantes de Educacion Primaria, siguiendo un diseno cuasiexperimental, pre-post con dos grupos, incluyendo formacion para docentes, padres y madres. Se han obtenido diferencias significativas en las dimensiones autoconciencia emocional, resolucion de problemas, uso responsable, tutorizacion digital docente y supervision familiar. Se concluye que el programa es efectivo, desarrollando en el alumnado las habilidades personales y tecnologicas evaluadas, y repercutiendo positivamente en la tutorizacion y supervision de sus docentes y progenitores.

Background Malignant gliomas are the most frequent primary brain tumors and remain among the most incurable cancers. Although the role of the gap junction protein, connexin43 (Cx43), has been deeply investigated in malignant gliomas, no compounds have been reported with the ability to recapitulate the tumor suppressor properties of this protein in in vivo glioma models. Methods TAT-Cx43266–283 a cell-penetrating peptide which mimics the effect of Cx43 on c-Src inhibition, was studied in orthotopic immunocompetent and immunosuppressed models of glioma. The effects of this peptide in brain cells were also analyzed. Results While glioma stem cell malignant features were strongly affected by TAT-Cx43266–283, these properties were not significantly modified in neurons and astrocytes. Intraperitoneally administered TAT-Cx43266–283 decreased the invasion of intracranial tumors generated by GL261 mouse glioma cells in immunocompetent mice. When human glioma stem cells were intracranially injected with TAT-Cx43266–283 into immunodeficient mice, there was reduced expression of the stemness markers nestin and Sox2 in human glioma cells at 7 days post-implantation. Consistent with the role of Sox2 as a transcription factor required for tumorigenicity, TAT-Cx43266–283 reduced the number and stemness of human glioma cells at 30 days post-implantation. Furthermore, TAT-Cx43266–283 enhanced the survival of immunocompetent mice bearing gliomas derived from murine glioma stem cells. Conclusion TAT-Cx43266–283 reduces the growth, invasion, and progression of malignant gliomas and enhances the survival of glioma-bearing mice without exerting toxicity in endogenous brain cells, which suggests that this peptide could be considered as a new clinical therapy for high-grade gliomas.

Glioblastomas are one of the most malignant tumors. Glioma Stem Cells (GSCs) are a subpopulation of cells resistant to standard treatments, responsible for tumor recurrence. Strong evidence supports that Neural Stem Cells (NSCs) from the subventricular zone (SVZ) are the origin of GSCs. This transition frequently concurs with epidermal growth factor receptor (EGFR) overexpression or mutations, such as EGFRvIII. Our group designed a cell penetrating peptide based on connexin43 (TAT-Cx43266-283) that inhibits the oncoprotein c-Src and therefore targets GSCs, increasing survival in glioma-bearing mice. Because c-Src and EGFR signaling are closely related, we explored the effect of TAT-Cx43266-283 in the transition of NSCs to GSCs. We compared the effect of TAT-Cx43266-283, control peptides, temozolomide and erlotinib, a common EGFR inhibitor, in SVZ NSCs (Control-NSCs) and murine NSC and patient-derived GSCs with key glioma-driver mutations in Nf1, PTEN and EGFR. EGFR signaling pathway was analyzed by Western blot. Furthermore, we are analyzing the effect of TAT-Cx43266-283 in a mouse model where tumors originate from SVZ NSCs with glioma-driver mutations. Our results showed a strong effect of TAT-Cx43266-283 in cell viability of NSCs and patient-derived GSCs with EGFR amplification or active EGFRvIII, without significant effects in Control-NSCs. Importantly, we found a lower effect of temozolomide, erlotinib, and other control peptides in these cells. Western blot analyses suggest that TAT-Cx43266-283 decreases EGFR, EGFRvIII and c-Src activity. Preliminary in vivo results suggest that TAT-Cx43266-283 decreases tumor size and enhances survival in mice bearing gliomas initiated by altered NSCs. So far, our results show that TAT-Cx43266-283 impairs EGFR signaling pathway with the subsequent reduction in the proliferation and survival of NSCs or GSCs with EGFR alterations. These results stress the relevance of TAT-Cx43266-283 as a future therapy against glioblastoma, alone or in combination with other treatments.

We report on the fabrication and characterization of a volatile organic compound sensor architecture addressing common drawbacks of photonic integrated sensors such as reusability and specificity. The proposed sensor, built on a silicon-on-insulator platform and based on arrayed waveguide interference, has a chemically selective polydimethylsiloxane polymer cladding, which encapsulates the waveguides and provides an expandable and permeable low refractive index material. This cladding material acts as the chemical transducer element, changing its optical properties when in contact with specific volatile organic compounds, whose presence in the context of environmental and public health protection is important to monitor. The sensor operates at room temperature and its selectivity was confirmed by multiple tests with water, toluene, chlorobenzene, and hexane, through which the sturdiness of the sensor was verified. A maximum spectral shift of about 22.8 nm was measured under testing with chlorobenzene, at a central wavelength of 1566.7 nm. In addition, a sensitivity of 234.8 pm/% was obtained for chlorobenzene mass percent concentrations, with a limit of detection of 0.24%m/m. The thermal sensitivity of the sensor has been found to be 0.9 nm/°C.

The article exposes the process of design and implementation of a training program for teachers that teach people with Visual Functional Diversity (VFD), taking into account their needs both in training and in the provision of resources in Nicaragua. To verify the effectiveness of the program, a quasi-experimental design was carried out with a non-equivalent pretest and posttest control group. The experimental group received training while the control group did not receive training. The evaluation of the results obtained after the application of the program was carried out through two instruments: an efficacy questionnaire and a satisfaction questionnaire. The results showed significant differences between the experimental and control group after the application of the program (Z = −4,383; p = 0.000) in favor of the experimental group. It is confirmed that the program is effective in training teachers on inclusive education for the visually impaired as the teachers who took part in the training program significantly increased their knowledge in that issue.

Skin fibroblasts were obtained from four patients with Williams-Beuren syndrome (WBS) carrying the typical 1.5 Mb or 1.8 Mb deletion at the 7q11.23 genomic region. Induced pluripotent stem cells (iPSCs) were generated by retroviral infection of fibroblasts with polycystronic vectors. The generated iPSC clones ESi059A, ESi060B and ESi068A had the 1.5 Mb deletion of 7q11.23 and ESi069A the 1.8 Mb, with no novel additional genomic alterations, stable karyotype, expressed pluripotency markers and could differentiate towards the three germ layers in vitro via embryoid body formation and in vivo by teratoma formation. WBS patient's lines are a valuable resource for in vitro modelling of WBS. This work was supported by the grant from Fundación Ramón Areces, the marathon “Todos Somos Raros, Todos Somos Únicos” P52, Spanish RETOS “RTI2018-101960-A-I00”, CERCA Programme / Generalitat de Catalunya; Red de Terapia Celular, TerCel, founded by Retics, RD12/0019/0034; Plataforma de Recursos Biomoleculares y Bioinformaticos, PRB2, PT13/0001/0041; both founded by Instituto de Salud Carlos III-ISCIII/FEDER. RC was recipient of Juan de la Cierva JCI-2012-14404 and Marie Skłodowska-Curie Actions (656359, H2020) and Ramón y Cajal (RYC-2017-21636) fellowships.

In this work, we investigate the dynamical state of the galaxy cluster Abell 2631, a massive structure located at the core of the Saraswati supercluster. To do this, we first solve a tension found in the literature regarding the weak-lensing mass determination of the cluster. We do this through a comprehensive weak-lensing analysis, exploring the power of the combination of shear and magnification data sets. We find $M_{200}^{\rm wl} = 8.7_{-2.9}^{+2.5} \times 10^{14}$ M$_\odot$. We also determined the mass based on the dynamics of spectroscopic members, corresponding to $M_{200}^{\rm dy} = 12.2\pm3.0 \times 10^{14}$ M$_\odot$, consistent within a 68 per cent CL with the weak-lensing estimate. The scenarios provided by the mass distribution and dynamics of galaxies are reconciled with those provided by X-ray observations in a scenario where A2631 is observed at a late stage of merging., 14 pages, 10 figures, 6 tables. Accepted on Nov, 13 for publication in MNRAS

Fairy tales are inserted in the reading formation of each individual in a different way. With regard to their contribution to child development, short stories expand and become an important pillar in the aid of the promotion of the imaginary, construction of self-consciousness, personality and other processes. The present study aimed to understand the potentiality of fairy tales and their contributions in recognized demarcations in childhood, seeking to carry out a qualitative research where this importance and potentiality was expressed, through a bibliographic review contemplating current and classic articles in which the theme was witnessed and could make contributions with the study. The results showed that fairy tales help in the whole process of child development and in the processes that permeate this stage, contributing to the child obtaining greater contribution with regard to imaginative capacity, resilience and taking other roles. It is notorious the imaginary/psychic enrichment that the tales provide the child in the different stages of its development, adapting together with its growth. Los cuentos de hadas se insertan en la formación de lectura de cada individuo de una manera diferente. Con respecto a su contribución al desarrollo infantil, los cuentos se expanden y se convierten en un pilar importante en la ayuda de la promoción del imaginario, la construcción de la autoconciencia, la personalidad y otros procesos. El presente estudio tenía como objetivo comprender la potencialidad de los cuentos de hadas y sus contribuciones en demarcaciones reconocidas en la infancia, buscando llevar a cabo una investigación cualitativa donde se expresaba esta importancia y potencialidad, a través de una revisión bibliográfica contemplando artículos actuales y clásicos en los que se presenciaba el tema y podía hacer contribuciones con el estudio. Los resultados mostraron que los cuentos de hadas ayudan en todo el proceso de desarrollo infantil y en los procesos que impregnan esta etapa, contribuyendo a que el niño obtenga una mayor contribución con respecto a la capacidad imaginativa, la resiliencia y la toma de otros roles. Es notorio el enriquecimiento imaginario/psíquico que los cuentos proporcionan al niño en las diferentes etapas de su desarrollo, adaptándose junto con su crecimiento. Os contos de fadas estão inseridos na formação leitora de cada indivíduo de forma distinta. No que diz respeito a sua contribuição no desenvolvimento infantil os contos se expandem e se transformam em um pilar importante no auxílio da fomentação do imaginário, construção da consciência de si, da personalidade e outros processos. O presente estudo teve como objetivo compreender a potencialidade dos contos de fadas e suas contribuições em demarcatórios reconhecidos na infância, buscando realizar uma pesquisa qualitativa onde essa importância e potencialidade fosse expressa, por meio de uma revisão bibliográfica contemplar artigos atuais e clássicos em que a temática fosse presenciada e pudessem realizar contribuições com o estudo. Os resultados mostraram que os contos de fadas auxiliam em todo o processo de desenvolvimento infantil e nos processos que permeiam essa etapa, contribuindo para que a criança obtenha maior aporte no que diz respeito a capacidade imaginativa, resiliência e tomada de outros papéis. É notório o enriquecimento imaginário/psíquico que os contos provêm a criança nas diferentes etapas do seu desenvolvimento, adaptando-se em conjunto com o seu crescimento.

This study brings considerations about the suicide of the elderly, seeking to inform aspects related to aging, as well as what is suicide and the possible reasons why the number of elderly people who commit this act is increasing considerably. In this way, we seek to sensitize society - whose knowledge about this theme is little or nonexistent - about the need to demystify the theme and have a more sensitive and welcoming look, carrying out effective and preventive actions with regard to suicide. Through the literature review in the academic Google, Pepsic and Scielo databases, it is possible to understand its multifactorial aspects, as well as to identify the intervention and prevention strategies that psychology uses in order to contribute to the management of suicide cases, attempts and ideations. Various studies support this theme by offering discussions about old age, suicide and the role of psychology in the therapeutic context. Intervention and prevention strategies should be promoted through access to health, therapeutic monitoring and social actions that assist in the insertion of the elderly in the community, in addition to rescuing bonds and family support. Depression and other diseases, addictions, retirement, neglect, are some of the factors identified as causes of suicide among the elderly population. The elderly need healthy bonds, care strategies, access to health and the maintenance of their rights for a dignified quality of life in this stage of life. Este estudio tiene como objetivo plantear consideraciones sobre el suicidio entre las personas mayores, buscando informar aspectos relacionados con el envejecimiento, así como dilucidar las posibles causas de muerte por suicidio en esta etapa de la vida, considerando que el número de casos aumenta considerablemente. De esta forma, se pretende desmitificar la temática aquí abordada con el fin de sensibilizar a la sociedad --cuyo conocimiento sobre esta temática es escaso o inexistente-- para obtener una mirada más acogedora, así como para llevar a cabo acciones eficaces y preventivas frente al suicidio. Las adicciones, la jubilación, el abandono, la depresión y otras enfermedades son algunos de los factores identificados como causas de suicidio entre la población anciana. Las personas mayores necesitan vínculos saludables, estrategias de atención, acceso a la salud y el mantenimiento de sus derechos para una calidad de vida digna. A través de la revisión de la literatura en las bases de datos Pepsic, Scielo y de la investigación realizada en el fondo de la biblioteca de la Universidad Franciscana (UFN), fue posible comprender los aspectos multifactoriales, así como identificar las estrategias de intervención y prevención que ofrece la psicología para el manejo de casos de suicidio, intentos e ideaciones. Se deben promover estrategias de intervención y prevención a través del acceso a la salud, el seguimiento terapéutico y las acciones sociales que coadyuven en la inserción de las personas mayores en la comunidad, además de rescatar los lazos y el apoyo familiar. Este estudo tem como objetivo trazer considerações acerca do suicídio entre idosos, buscando informar aspectos referentes ao envelhecimento, bem como elucidar as possíveis causas de morte por suicídio nesta etapa da vida, considerando que o número de casos aumenta consideravelmente. Desta forma, procura-se desmistificar o tema aqui abordado a fim de sensibilizar a sociedade - cujo conhecimento acerca dessa temática é pouco ou inexistente - a obter um olhar mais acolhedor, assim como realizar ações efetivas e preventivas no que se refere ao suicídio. Vícios, aposentadoria, negligência, depressão e outras doenças, são alguns dos fatores apontados como causas de suicídio entre a população idosa. Os idosos necessitam de vínculos saudáveis, estratégias de cuidados, acesso a saúde e da manutenção de seus direitos para uma qualidade de vida digna. Através da revisão de literatura nas bases de dados Pepsic, Scielo e pesquisas realizadas no acervo da biblioteca da Universidade Franciscana (UFN), foi possível compreender os aspectos multifatoriais, bem como identificar as estratégias de intervenção e prevenção que a psicologia oferece para o manejo dos casos de suicídio, tentativas e ideações. As estratégias de intervenção e prevenção devem ser promovidas através de acesso a saúde, acompanhamento terapêutico e ações sociais que auxiliem na inserção dos idosos na comunidade, além do resgate de vínculos e do suporte familiar.

This study aims to seek an understanding of the role and importance of the school psychologist in the face of the demands of adolescence, in addition to discussing the main challenges faced by these professionals in this area, based on the first season of the “13 Reasons Why” series. In this way, it seeks to sensitize people about the need to have a more sensitive and welcoming look, aiming to promote quality mental health in the school environment. The series shows the context that many teenagers experience in their schools, from problems with drug use to sexual abuse, aggression and lack of empathic adults seeking to understand and help them. The literature review was used as a research methodology, making it possible to understand the importance of the school psychologist, acting with qualified and welcoming listening to adolescents in their demands. Bearing in mind that they are in a phase permeated by doubts, in which the transformations experienced cause restlessness and strangeness in relation to themselves, they need a qualified help, which is given by the professional of Psychology. It is in this sense that schools become important places for discussing topics considered taboo, such as suicide, in view of the large number of adolescents who attend it. Challenges that are still often encountered by psychologists are the lack of open spaces for action in the school environment and questions about their functions, requiring greater visibility for this area of ​​expertise. It was found in this work that the series can make the adolescents identify with the topics covered and then start talking more about their feelings, especially in the school environment, where they spend most of their time, being able to exchange experiences with others. But, for this to happen, it is necessary that the school recognizes such importance and starts to insert the Psychology professional in its staff. Este estudio tiene como objetivo buscar la comprensión del papel e importancia del psicólogo escolar frente a las demandas de la adolescencia, además de discutir los principales desafíos que enfrentan estos profesionales en esta área, a partir de la primera temporada de la serie “Por trece razones”. De esta forma, se busca sensibilizar a las personas sobre la necesidad de tener una mirada más sensible y acogedora, con el objetivo de promover una salud mental de calidad en el entorno escolar. La serie muestra el contexto que viven muchos adolescentes en sus escuelas, desde problemas con el uso de drogas hasta abuso sexual, agresión y falta de adultos empáticos que busquen comprenderlos y ayudarlos. La revisión de la literatura se utilizó como metodología de investigación, permitiendo comprender la importancia del psicólogo escolar, actuando con una escucha calificada y acogedora de los adolescentes en sus demandas. Teniendo en cuenta que se encuentran en una fase impregnada de dudas, en la que las transformaciones vividas provocan inquietudes y extrañezas en su relación con ellos mismos, necesitan una ayuda cualificada, que es brindada por el profesional de Psicología. Es en este sentido que las escuelas se convierten en lugares importantes para la discusión de temas considerados tabú, como el suicidio, ante la gran cantidad de adolescentes que asisten a ella. Los desafíos que aún enfrentan los psicólogos son la falta de espacios abiertos en el entorno escolar y las preguntas sobre sus funciones, lo que requiere una mayor visibilidad para esta área de especialización. Se encontró en este trabajo que la serie puede hacer que los adolescentes se identifiquen con los temas tratados y luego comiencen a hablar más sobre sus sentimientos, especialmente en el ámbito escolar, donde pasan la mayor parte de su tiempo, pudiendo intercambiar experiencias. con otros. Pero, para que esto suceda, es necesario que la escuela reconozca tal importancia y comience a insertar al profesional de Psicología en su plantilla. Este estudo tem como objetivo buscar uma compreensão do papel e da importância do psicólogo escolar frente às demandas da adolescência, além de discutir os principais desafios enfrentados por esses profissionais nessa área, baseando-se na primeira temporada da série “13 Reasons Why”. Desta forma, procura-se sensibilizar as pessoas sobre a necessidade de se ter um olhar mais sensível e acolhedor, visando a promoção de saúde mental de qualidade no âmbito escolar. A série mostra o contexto que muitos adolescentes vivenciam em suas escolas, desde problemas com uso de drogas até abuso sexual, agressividade e falta de adultos empáticos buscando entendê-los e ajudá-los. Utilizou-se como metodologia de pesquisa a revisão de literatura, sendo possível compreender a importância do psicólogo escolar, atuando com uma escuta qualificada e acolhedora aos adolescentes em suas demandas. Tendo em vista que estão em uma fase permeada por dúvidas, em que as transformações vividas provocam inquietação e estranheza em relação a si próprios, estes necessitam de um auxílio qualificado, que se dá através do profissional de Psicologia. É nesse sentido que escolas se tornam importantes locais para a discussão de temáticas consideradas tabu, como o suicídio, tendo em vista o grande número de adolescentes que a frequentam. São desafios ainda encontrados muitas vezes pelos psicólogos a falta de abertura de espaços de atuação no âmbito escolar e os questionamentos sobre suas funções, sendo necessária uma maior visibilidade para esta área de atuação. Constatou-se neste trabalho que a série pode vir a fazer com que os adolescentes identifiquem-se com os temas abordados e então passem a falar mais sobre seus sentimentos, principalmente no ambiente escolar, onde passam a maior parte do tempo, podendo trocar experiências uns com os outros. Mas, para que isso ocorra, é necessário que a escola reconheça tal importância e passe a inserir o profissional de Psicologia em seu quadro de funcionários.

This study aims at identifying the contributions of playing to the child development, socialization and apprenticeship, and still, at understanding how technology has influenced human relationships and how this influence has impacted childhood and plays. It is intended to raise sensitize in parents, educators and Society concerning the playfulness that is being lived during childhood, being that playing not only a free time activity, but a learning act. Trough bibliographic research it is possible to understand the importance of playing. By playing, the child finds support for his/her physical, intellectual and social development, and yet, the development of identity and autonomy. The play is a means the kid inserts him/herself in society and culture, exploring the world and its possibilities. Nowadays, playing has been suffering changes. Currently, it is common that children replace traditional toys for the use of technology, and parents are also more and more inserted in the virtual world, what meaningfully interferes in the relationships between parents and children, making them far from each other and the living and dialogue lessen and lessen. The indiscriminate use of technology deconstructs the affective bonds among the family members, collaborating for the lack of emotional reference in children. Parents need to promote a harmonious living relationship and a healthy environment, in which the child can play and develop, with the attentive care and active and affective participation, effectively corroborating in the construction of their apprenticeship. Este estudio tiene como objetivo identificar las contribuciones del juego al desarrollo, la socialización y el aprendizaje del niño y comprender cómo la tecnología ha estado influyendo en las relaciones humanas y cómo esta misma influencia ha tenido un impacto en la infancia y el juego. Se busca sensibilizar a padres, educadores y sociedad sobre la alegría que se debe vivir en la infancia, y el juego no es solo una actividad de ocio, sino un acto de aprendizaje. A través de la investigación bibliográfica es posible comprender la importancia del juego. A través del juego, el niño encuentra ayuda para su desarrollo físico, intelectual y social, además del desarrollo de su identidad y autonomía. El juego es un medio por el cual los niños se insertan en la sociedad y la cultura, explorando el mundo y sus posibilidades. Hoy en día, el juego ha sufrido cambios. Hoy en día es común que los niños intercambien juguetes tradicionales por el uso de la tecnología y también los padres, cada vez están más insertados en el mundo virtual, lo que interfiere significativamente en las relaciones sociales entre padres e hijos, distanciándolos y haciéndolo cada vez más escaso. diálogo e interacciones. El uso indiscriminado de la tecnología deconstruye el vínculo emocional entre los miembros de la familia, contribuyendo a la falta de referencia emocional en los niños. Los padres necesitan promover una relación armoniosa y un ambiente sano, donde el niño pueda jugar y desarrollarse, junto con la mirada atenta y la participación activa y cariñosa de los mismos, corroborando efectivamente la construcción de su aprendizaje. Este estudo tem como objetivo identificar as contribuições do brincar ao desenvolvimento infantil, socialização e aprendizagem e ainda compreender como a tecnologia vem influenciando nas relações humanas e como esta mesma influência tem repercutido na infância e nas brincadeiras. Procura-se sensibilizar pais, educadores e sociedade sobre a ludicidade que deve estar sendo vivenciada na infância, sendo o brincar não somente uma atividade de lazer, mas sim, um ato de aprendizagem. Através da pesquisa bibliográfica é possível compreender a importância do brincar. Por meio da brincadeira, a criança encontra auxílio para seu desenvolvimento físico, intelectual e social, além do desenvolvimento da identidade e autonomia. A brincadeira é um meio pelo qual a criança se insere na sociedade e na cultura, explorando o mundo e as suas possibilidades. Na contemporaneidade o brincar vem sofrendo alterações. Atualmente é comum as crianças trocarem brinquedos tradicionais pelo uso da tecnologia e também os pais, estão cada vez mais inseridos no mundo virtual, o que interfere de forma significativa nas relações de convívio entre pais e filhos, distanciando-os e tornando cada vez mais escasso o diálogo e as interações. O uso indiscriminado da tecnologia desconstrói o vínculo afetivo entre os membros da família, colaborando para a ausência de referência emocional nas crianças. Os pais precisam promover uma relação de convivência harmoniosa e um ambiente saudável, onde a criança possa brincar e se desenvolver, juntamente com o olhar atento e a participação ativa e afetuosa destes, corroborando de forma efetiva na construção de suas aprendizagens.

A high performance compact silicon photonics polarization splitter is proposed and demonstrated. The splitter is based on an asymmetric directional coupler. High extinction ratios at the through and drop ports of the polarization splitter are achieved by using an on-chip TE-pass polarizer and a TM-pass polarizer, respectively. The splitter, implemented on a silicon-on-insulator platform with a 220 nm-thick silicon device layer, has a measured insertion loss lower than 1 dB (for both TE and TM modes) and extinction ratio greater than 25 dB (for TM mode) and greater than 36 dB (for TE mode), in the wavelength range from 1.5 µm to 1.6 µm. The footprint of the device is 12 µm × 15 µm.

Este estudo tem como objetivo buscar uma compreensão do papel e da importância do psicólogo escolar frente às demandas da adolescência, além de discutir os principais desafios enfrentados por esses profissionais nessa área, baseando-se na primeira temporada da série “13 Reasons Why”. Desta forma, procura-se sensibilizar as pessoas sobre a necessidade de se ter um olhar mais sensível e acolhedor, visando a promoção de saúde mental de qualidade no âmbito escolar. A série mostra o contexto que muitos adolescentes vivenciam em suas escolas, desde problemas com uso de drogas até abuso sexual, agressividade e falta de adultos empáticos buscando entendê-los e ajudá-los. Utilizou-se como metodologia de pesquisa a revisão de literatura, sendo possível compreender a importância do psicólogo escolar, atuando com uma escuta qualificada e acolhedora aos adolescentes em suas demandas. Tendo em vista que estão em uma fase permeada por dúvidas, em que as transformações vividas provocam inquietação e estranheza em relação a si próprios, estes necessitam de um auxílio qualificado, que se dá através do profissional de Psicologia. É nesse sentido que escolas se tornam importantes locais para a discussão de temáticas consideradas tabu, como o suicídio, tendo em vista o grande número de adolescentes que a frequentam. São desafios ainda encontrados muitas vezes pelos psicólogos a falta de abertura de espaços de atuação no âmbito escolar e os questionamentos sobre suas funções, sendo necessária uma maior visibilidade para esta área de atuação. Constatou-se neste trabalho que a série pode vir a fazer com que os adolescentes identifiquem-se com os temas abordados e então passem a falar mais sobre seus sentimentos, principalmente no ambiente escolar, onde passam a maior parte do tempo, podendo trocar experiências uns com os outros. Mas, para que isso ocorra, é necessário que a escola reconheça tal importância e passe a inserir o profissional de Psicologia em seu quadro de funcionários.

This work explores the development of highly sensitive salinity sensors. The demonstrated sensors are based on optical fibres and consist on Fabry-Pérot optical cavities formed by optimized processes that include chemical etching and fusion splicing, on which microfluidic channels are milled by focused ion beam. Two configurations are presented and their performance compared, including a design that makes use of Vernier-effect for the simultaneous measurement of salinity and temperature with high sensitivity. The interrogation of the devices is carried out by spectral measurements using a broadband light source yielding sensitivities to salinity up to 82.61 nm/M, or 6830.0 nm/RIU.

This study aims to verify in the scientific literature the particularities of Alzheimer's Disease, the impacts on family members and caregivers, relating to the activities of the Integrated Multidisciplinary Assistance to Caregivers of People with Alzheimer's Disease (AMICA) project at the Franciscana University. The data collection was the search for content present in previously published materials, such as national scientific articles, journals, theses and dissertations, coming from open access databases, such as CAPES Journals, Scielo, Disciplinarum Scientia and Virtual Libraries. Also, through participant observations, technical visits were made at AMICA and through this, reports of experiences described during this work. Consequently, an intervention planning was made, and then, the action, with a view to the dissemination of the project in other areas outside the university. The results indicate knowledge about the pathology, its definition, cause, symptoms and limitations, as well as the importance of looking at caregivers and the functioning in the group mentioned. We conclude by emphasizing that the theme is ideal for informing those involved and interested, reinforcing the value of the existence of a support group along the lines of AMICA. Este estudio tiene como objetivo verificar en la literatura científica las particularidades de la enfermedad de Alzheimer, los impactos en los miembros de la familia y los cuidadores, en relación con las actividades del proyecto de Asistencia Multidisciplinaria Integrada para Cuidadores de Personas con Enfermedad de Alzheimer (AMICA) en la Universidad Franciscana. La recopilación de datos fue la búsqueda de contenido presente en materiales publicados previamente, como artículos científicos nacionales, revistas, tesis y disertaciones, procedentes de bases de datos de acceso abierto, como CAPES Journals, Scielo, Disciplinarum Scientia y Bibliotecas virtuales. Además, a través de observaciones de los participantes, se realizaron visitas técnicas en AMICA y, a través de esto, informes de experiencias descritas durante este trabajo. En consecuencia, se realizó una planificación de la intervención y, por lo tanto, la acción, con miras a la difusión del proyecto en otras áreas fuera de la universidad. Los resultados indican conocimiento sobre la patología, su definición, causa, síntomas y limitaciones, así como la importancia de mirar a los cuidadores y el funcionamiento en el grupo mencionado. Concluimos enfatizando que el tema es ideal para informar a los involucrados e interesados, reforzando el valor de la existencia de un grupo de apoyo en la línea de AMICA. O presente estudo tem como objetivo verificar na literatura científica as particularidades da Doença de Alzheimer, os impactos nos familiares e cuidadores, relacionando com as atividades do projeto de Assistência Multidisciplinar Integrada aos Cuidadores de Pessoas com Doença de Alzheimer (AMICA) da Universidade Franciscana. A coleta de dados se deu da busca por conteúdos presentes em materiais já publicados, como artigos científicos nacionais, periódicos, teses e dissertações, oriundos de bases de dados de livre acesso, como Periódicos da CAPES, Scielo, Disciplinarum Scientia e Bibliotecas Virtuais. Ainda, através de observações participantes, efetuou-se visitas técnicas no AMICA e por intermédio disto, relatos de experiências descritos no decorrer deste trabalho. Consequentemente, fez-se um planejamento de intervenção e logo, a ação, tendo em vista a divulgação do projeto em outros âmbitos externos à universidade. Os resultados obtidos apontam conhecimentos sobre a patologia, sua definição, causa, sintomas e limitações, e também a importância do olhar voltado aos cuidadores e o funcionamento no grupo mencionado. Conclui-se ressaltando que a temática é ideal para informar os envolvidos e interessados, reforçando o valor da existência de um grupo de apoio nos moldes do AMICA.

Background Glioblastoma is the most aggressive primary brain tumour and has a very poor prognosis. Inhibition of c-Src activity in glioblastoma stem cells (GSCs, responsible for glioblastoma lethality) and primary glioblastoma cells by the peptide TAT-Cx43266–283 reduces tumorigenicity, and boosts survival in preclinical models. Because c-Src can modulate cell metabolism and several reports revealed poor clinical efficacy of various antitumoral drugs due to metabolic rewiring in cancer cells, here we explored the inhibition of advantageous GSC metabolic plasticity by the c-Src inhibitor TAT-Cx43266-283. Methods Metabolic impairment induced by the c-Src inhibitor TAT-Cx43266-283 in vitro was assessed by fluorometry, western blotting, immunofluorescence, qPCR, enzyme activity assays, electron microscopy, Seahorse analysis, time-lapse imaging, siRNA, and MTT assays. Protein expression in tumours from a xenograft orthotopic glioblastoma mouse model was evaluated by immunofluorescence. Findings TAT-Cx43266–283 decreased glucose uptake in human GSCs and reduced oxidative phosphorylation without a compensatory increase in glycolysis, with no effect on brain cell metabolism, including rat neurons, human and rat astrocytes, and human neural stem cells. TAT-Cx43266-283 impaired metabolic plasticity, reducing GSC growth and survival under different nutrient environments. Finally, GSCs intracranially implanted with TAT-Cx43266–283 showed decreased levels of important metabolic targets for cancer therapy, such as hexokinase-2 and GLUT-3. Interpretation The reduced ability of TAT-Cx43266-283–treated GSCs to survive in metabolically challenging settings, such as those with restricted nutrient availability or the ever-changing in vivo environment, allows us to conclude that the advantageous metabolic plasticity of GSCs can be therapeutically exploited through the specific and cell-selective inhibition of c-Src by TAT-Cx43266-283. Funding Spanish Ministerio de Economia y Competitividad (FEDER BFU2015-70040-R and FEDER RTI2018-099873-B-I00), Fundacion Ramon Areces. Fellowships from the Junta de Castilla y Leon, European Social Fund, Ministerio de Ciencia and Asociacion Espanola Contra el Cancer (AECC).