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2. Diabetic ketoacidosis drives COVID-19 related hospitalizations in children with type 1 diabetes.

Author

Alonso, Guy Todd, Ebekozien, Osagie, Gallagher, Mary Pat, Rompicherla, Saketh, Lyons, Sarah K, Choudhary, Abha, Majidi, Shideh, Pinnaro, Catherina T, Balachandar, Sadana, Gangat, Mariam, Curda Roberts, Alissa Jeanne, Marks, Brynn E, Creo, Ana, Sanchez, Janine, Seeherunvong, Tossaporn, Jimenez-Vega, Jose, Patel, Neha S, Wood, Jamie R, Gabriel, Liana, Sumpter, Kathryn M, Wilkes, Meredith, Rapaport, Robert, Cymbaluk, Anna, Wong, Jenise C, Sanda, Srinath, and Albanese-O'neill, Anastasia

Subjects
Humans, Diabetic Ketoacidosis, Diabetes Mellitus, Type 1, Disease Progression, Hospitalization, Registries, Risk Assessment, Risk Factors, Cross-Sectional Studies, Age Factors, Up-Regulation, Adolescent, Child, Child, Preschool, Infant, Infant, Newborn, United States, Female, Male, Biomarkers, COVID-19, Glycated Hemoglobin, 1型糖尿病, DKA, pediatric, type 1 diabetes, 儿科, 新型冠状病毒肺炎, Diabetes, Pediatric, Prevention, Metabolic and endocrine, Clinical Sciences, Public Health and Health Services
Abstract

BackgroundDiabetes is a risk factor for poor COVID-19 outcomes, but pediatric patients with type 1 diabetes are poorly represented in current studies.MethodsT1D Exchange coordinated a US type 1 diabetes COVID-19 registry. Forty-six diabetes centers submitted pediatric cases for patients with laboratory confirmed COVID-19. Associations between clinical factors and hospitalization were tested with Fisher's Exact Test. Logistic regression was used to calculate odds ratios for hospitalization.ResultsData from 266 patients with previously established type 1 diabetes aged

Published
2021

10. Commentary on the T1D exchange quality improvement collaborative learning session November 2023 abstracts.

Author

Majidi, Shideh, Agarwal, Shivani, Rioles, Nicole, Rapaport, Robert, and Ebekozien, Osagie

Subjects
COLLABORATIVE learning, INSULIN pumps, CONTINUOUS glucose monitoring, BLOOD sugar monitors, TYPE 1 diabetes, DIABETES in children, TEAM learning approach in education
Abstract

The T1D Exchange Quality Improvement Collaborative (T1DX-QI) is a network of over 55 diabetes centers that aims to improve diabetes care and outcomes for individuals with type 1 diabetes (T1D). The network focuses on refining best practices, emphasizing quality of care, and using real-world data to drive improvements. The November 2023 conference highlighted various topics, including psychosocial aspects of care and improving technology advancement and access. The abstracts presented at the conference covered a range of subjects, such as screening for eating disorders and anxiety, implementing social determinants of health screening, identifying barriers to technology use, and exploring remote patient monitoring. The T1DX-QI Collaborative continues to work towards improving overall health outcomes, reducing complications, and closing health equity gaps for people living with T1D. [Extracted from the article]

Published
2024
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11. Updated consensus guidelines on the management of Phelan–McDermid syndrome

Author

Srivastava, Siddharth, primary, Sahin, Mustafa, additional, Buxbaum, Joseph D., additional, Berry‐Kravis, Elizabeth, additional, Soorya, Latha Valluripalli, additional, Thurm, Audrey, additional, Bernstein, Jonathan A., additional, Asante‐Otoo, Afua, additional, Bennett, William E., additional, Betancur, Catalina, additional, Brickhouse, Tegwyn H., additional, Passos Bueno, Maria Rita, additional, Chopra, Maya, additional, Christensen, Celanie K., additional, Cully, Jennifer L., additional, Dies, Kira, additional, Friedman, Kate, additional, Gummere, Brittany, additional, Holder, J. Lloyd, additional, Jimenez‐Gomez, Andres, additional, Kerins, Carolyn A., additional, Khan, Omar, additional, Kohlenberg, Teresa, additional, Lacro, Ronald V., additional, Levi, Lori A., additional, Levy, Tess, additional, Linnehan, Diane, additional, Eva, Loth, additional, Moshiree, Baharak, additional, Neumeyer, Ann, additional, Paul, Scott M., additional, Phelan, Katy, additional, Persico, Antonio, additional, Rapaport, Robert, additional, Rogers, Curtis, additional, Saland, Jeffrey, additional, Sethuram, Swathi, additional, Shapiro, Janine, additional, Tarr, Phillip I., additional, White, Kerry M., additional, Wickstrom, Jordan, additional, Williams, Kent M., additional, Winrow, Dana, additional, Wishart, Brian, additional, and Kolevzon, Alexander, additional

Published
2023
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16. International Consensus Guideline on Small for Gestational Age:Etiology and Management From Infancy to Early Adulthood

Author

Hokken-Koelega, Anita C.S., van der Steen, Manouk, Boguszewski, Margaret C.S., Cianfarani, Stefano, Dahlgren, Jovanna, Horikawa, Reiko, Mericq, Veronica, Rapaport, Robert, Alherbish, Abdullah, Braslavsky, Debora, Charmandari, Evangelia, Chernausek, Steven D., Cutfield, Wayne S., Dauber, Andrew, Deeb, Asma, Goedegebuure, Wesley J., Hofman, Paul L., Isganatis, Elvira, Jorge, Alexander A., Kanaka-Gantenbein, Christina, Kashimada, Kenichi, Khadilkar, Vaman, Luo, Xiao Ping, Mathai, Sarah, Nakano, Yuya, Yau, Mabel, Hokken-Koelega, Anita C.S., van der Steen, Manouk, Boguszewski, Margaret C.S., Cianfarani, Stefano, Dahlgren, Jovanna, Horikawa, Reiko, Mericq, Veronica, Rapaport, Robert, Alherbish, Abdullah, Braslavsky, Debora, Charmandari, Evangelia, Chernausek, Steven D., Cutfield, Wayne S., Dauber, Andrew, Deeb, Asma, Goedegebuure, Wesley J., Hofman, Paul L., Isganatis, Elvira, Jorge, Alexander A., Kanaka-Gantenbein, Christina, Kashimada, Kenichi, Khadilkar, Vaman, Luo, Xiao Ping, Mathai, Sarah, Nakano, Yuya, and Yau, Mabel

Abstract

This International Consensus Guideline was developed by experts in the field of small for gestational age (SGA) of 10 pediatric endocrine societies worldwide. A consensus meeting was held and 1300 articles formed the basis for discussions. All experts voted about the strengths of the recommendations. The guideline gives new and clinically relevant insights into the etiology of short stature after SGA birth, including novel knowledge about (epi)genetic causes. Further, it presents long-term consequences of SGA birth and also reviews new treatment options, including treatment with gonadotropin-releasing hormone agonist (GnRHa) in addition to growth hormone (GH) treatment, as well as the metabolic and cardiovascular health of young adults born SGA after cessation of childhood GH treatment in comparison with appropriate control groups. To diagnose SGA, accurate anthropometry and use of national growth charts are recommended. Follow-up in early life is warranted and neurodevelopment evaluation in those at risk. Excessive postnatal weight gain should be avoided, as this is associated with an unfavorable cardiometabolic health profile in adulthood. Children born SGA with persistent short stature < −2.5 SDS at age 2 years or < −2 SDS at 3 to 4 years of age, should be referred for diagnostic workup. In case of dysmorphic features, major malformations, microcephaly, developmental delay, intellectual disability, and/or signs of skeletal dysplasia, genetic testing should be considered. Treatment with 0.033 to 0.067 mg GH/kg/ day is recommended in case of persistent short stature at age of 3 to 4 years. Adding GnRHa treatment could be considered when short adult height is expected at pubertal onset. All young adults born SGA require counseling to adopt a healthy lifestyle.

Published
2023

18. International Consensus Guideline on Small for Gestational Age: Etiology and Management From Infancy to Early Adulthood

Author

Hokken-Koelega, Anita C S, primary, van der Steen, Manouk, additional, Boguszewski, Margaret C S, additional, Cianfarani, Stefano, additional, Dahlgren, Jovanna, additional, Horikawa, Reiko, additional, Mericq, Veronica, additional, Rapaport, Robert, additional, Alherbish, Abdullah, additional, Braslavsky, Debora, additional, Charmandari, Evangelia, additional, Chernausek, Steven D, additional, Cutfield, Wayne S, additional, Dauber, Andrew, additional, Deeb, Asma, additional, Goedegebuure, Wesley J, additional, Hofman, Paul L, additional, Isganatis, Elvira, additional, Jorge, Alexander A, additional, Kanaka-Gantenbein, Christina, additional, Kashimada, Kenichi, additional, Khadilkar, Vaman, additional, Luo, Xiao-Ping, additional, Mathai, Sarah, additional, Nakano, Yuya, additional, and Yau, Mabel, additional

Published
2023
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24. Growth Hormone Stimulation Testing: To Test or Not to Test? That Is One of the Questions

Author

Yau, Mabel and Rapaport, Robert

Subjects
Human Growth Hormone, Growth Hormone, Endocrinology, Diabetes and Metabolism, Puberty, Humans, Insulin-Like Growth Factor I, Child, Dwarfism, Pituitary
Abstract

The evaluation of children with short stature includes monitoring over a prolonged period to establish a growth pattern as well as the exclusion of chronic medical conditions that affect growth. After a period of monitoring, evaluation, and screening, growth hormone stimulation testing is considered when the diagnosis of growth hormone deficiency (GHD) is entertained. Though flawed, growth hormone stimulation tests remain part of the comprehensive evaluation of growth and are essential for the diagnosis of growth hormone (GH) deficiency. Variables including testing length, growth hormone assay and diagnostic cut off affect results. Beyond the intrinsic issues of testing, results of GH stimulation testing can be influenced by patient characteristics. Various factors including age, gender, puberty, nutritional status and body weight modulate the secretion of GH.

Published
2022

25. Fasting Serum IGFBP-1 as a Marker of Insulin Resistance in Diverse School Age Groups

Author

Bhangoo, Amrit, primary, Gupta, Rishi, additional, Shelov, Steve P., additional, Carey, Dennis E., additional, Accacha, Siham, additional, Fennoy, Ilene, additional, Altshuler, Lisa, additional, Lowell, Barbara, additional, Rapaport, Robert, additional, Rosenfeld, Warren, additional, Speiser, Phyllis W., additional, Ten, Svetlana, additional, and Rosenbaum, Michael, additional

Published
2022
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27. Trends in Type 1 Diabetic Ketoacidosis During COVID-19 Surges at 7 US Centers: Highest Burden on non-Hispanic Black Patients

Author

Lavik, Andrew R, primary, Ebekozien, Osagie, additional, Noor, Nudrat, additional, Alonso, G Todd, additional, Polsky, Sarit, additional, Blackman, Scott M, additional, Chen, Justin, additional, Corathers, Sarah D, additional, Demeterco-Berggren, Carla, additional, Gallagher, Mary Pat, additional, Greenfield, Margaret, additional, Garrity, Ashley, additional, Rompicherla, Saketh, additional, Rapaport, Robert, additional, and Yayah Jones, Nana-Hawa, additional

Published
2022
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32. Contributors

Author

Backeljauw, Philippe F., primary, Battelino, Tadej, additional, Bondy, Carolyn A., additional, Chandler, Donald Walt, additional, Chia, Dennis J., additional, Chun, Kelly Y., additional, Cohen, Pinchas, additional, Cooke, David W., additional, Couch, Sarah C., additional, Daniels, Stephen R., additional, Dattani, Mehul Tulsidas, additional, De Leo´n, Diva D., additional, Deladoëy, Johnny, additional, Diamond, Frank B., additional, Dunkel, Leo, additional, Flück, Christa E., additional, Haller, Michael J., additional, Kublaoui, Bassil, additional, Langdon, David R., additional, Lee, Peter A., additional, Levine, Michael A., additional, Lustig, Robert H., additional, Majzoub, Joseph A., additional, Menon, Ram K., additional, Miller, Walter L., additional, Muglia, Louis J., additional, Nakamoto, Jon, additional, Palmert, Mark R., additional, Pepkowitz, Samuel H., additional, Phillip, Moshe, additional, Radovick, Sally, additional, Rapaport, Robert, additional, Rivkees, Scott A., additional, Root, Allen W., additional, Rosenfeld, Ron G., additional, Rosenfield, Robert L., additional, Saenger, Paul, additional, Schatz, Desmond A., additional, Sperling, Mark A., additional, Srivatsa, Abhinash, additional, Stanley, Charles A., additional, Stratakis, Constantine A., additional, Tamborlane, William V., additional, Thornton, Paul S., additional, Trucco, Massimo, additional, Vliet, Guy Van, additional, Waguespack, Steven G., additional, Weinzimer, Stuart A., additional, Weiss, Ram, additional, Winter, William E., additional, Witchel, Selma Feldman, additional, and Ying, Anita K., additional

Published
2014
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39. Graves Disease in Infancy

Author

Beliard, Kara A, primary, Shyamkumarb, Srinidhi, additional, Yau, Mabel, additional, Mintz, Cassie, additional, and Rapaport, Robert, additional

Published
2021
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50. Association of Anterior Pituitary Volume by Magnetic Resonance Imaging with Growth Parameters and the Growth Hormone-Insulin-Like Growth Factor-1 Axis

Author

Regelmann, Molly O, primary, Delman, Bradley N, additional, Tenore, Andrew, additional, Annunziato, Rachel A, additional, Klein, Michelle L, additional, Chacko, Elizabeth, additional, Iazzetti, Loretta, additional, Chia, Dennis, additional, Hyman, Sharon J, additional, Wallach, Elizabeth, additional, and Rapaport, Robert, additional

Published
2011
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