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Your search keyword '"Rao, Sheetal S"' showing total 7 results
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7 results on '"Rao, Sheetal S"'

1. A randomized phase 2 trial of idiotype vaccination and adoptive autologous T-cell transfer in patients with multiple myeloma

Author

Qazilbash, Muzaffar H., Saini, Neeraj Y., Cha, Soung-chul, Wang, Zhe, Stadtmauer, Edward A., Baladandayuthapani, Veerabhadran, Lin, Heather, Tross, Beryl, Honhar, Medhavi, Rao, Sheetal S., Kim, Kunhwa, Popescu, Michael, Szymura, Szymon, Zhang, Tiantian, Anderson, Aaron, Bashir, Qaiser, Shpall, Elizabeth J., Orlowski, Robert Z., Levine, Bruce L., Kerr, Naseem, Garfall, Alfred, Cohen, Adam, Vogl, Dan T., Dengel, Karen, June, Carl H., Champlin, Richard, and Kwak, Larry W.

Published
2022
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2. Generation of a new therapeutic peptide that depletes myeloid-derived suppressor cells in tumor-bearing mice

Author

Qin, Hong, Lerman, Beatrisa, Sakamaki, Ippei, Wei, Guowei, Cha, Soungchul C., Rao, Sheetal S., Qian, Jianfei, Hailemichael, Yared, Nurieva, Roza, Dwyer, Karen C., Roth, Johannes, Yi, Qing, Overwijk, Willem W., and Kwak, Larry W.

Subjects
Tumors -- Analysis -- Health aspects -- Development and progression -- Genetic aspects -- Care and treatment -- Research, Immune response -- Physiological aspects -- Genetic aspects -- Research, Peptides -- Analysis -- Health aspects -- Physiological aspects -- Genetic aspects -- Research, Biological sciences, Health
Abstract

Immune evasion is an emerging hallmark of cancer progression. However, functional studies to understand the role of myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment are limited by the lack of available specific cell surface markers. We adapted a competitive peptide phage display platform to identify candidate peptides binding MDSCs specifically and generated peptide-Fc fusion proteins (peptibodies). In multiple tumor models, intravenous peptibody injection completely depleted blood, splenic and intratumoral MDSCs in tumor-bearing mice without affecting proinflammatory immune cell types, such as dendritic cells. Whereas control Gr-1-specific antibody primarily depleted granulocytic MDSCs, peptibodies depleted both granulocytic and monocytic MDSC subsets. Peptibody treatment was associated with inhibition of tumor growth in vivo, which was superior to that achieved with Gr-1-specific antibody. Immunoprecipitation of MDSC membrane proteins identified S100 family proteins as candidate targets. Our strategy may be useful to identify new diagnostic and therapeutic surface targets on rare cell subtypes, including human MDSCs., Activating the immune system has emerged as a promising way to treat cancer. Recent successful phase 3 clinical trials of therapeutic cancer vaccines include the US Food and Drug Administration-approved [...]

Published
2014
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3. A Novel Therapeutic DNA Vaccine Elicits Reduction of Tumor Clones and Favorable Perturbations in the Immune Microenvironment in Patients (pts) with Untreated Smoldering Waldenström Macroglobulinemia (sWM)

Author

Thomas, Sheeba K., primary, Cha, Soung-chul, additional, Parshottam, Sapna R, additional, Rao, Sheetal S., additional, Olsem, Jasper B., additional, Crumpton, Brandon N., additional, Szymura, Szymon, additional, Wang, Zhe, additional, Anderson, Aaron, additional, Feng, Lei, additional, Lee, Hans C., additional, Manasanch, Elisabet E., additional, Patel, Krina K., additional, Weber, Donna M., additional, Orlowski, Robert Z., additional, Neelapu, Sattva S., additional, and Kwak, Larry W, additional

Published
2020
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4. Phase I trial of a novel DNA vaccine in patients (pts) with smoldering Waldenstrom macroglobulinemia (sWM).

Author

Thomas, Sheeba K., primary, Cha, Soungchul, additional, Parshottam, Sapna R, additional, Rao, Sheetal S, additional, Olsem, Jasper B., additional, Crumpton, Brandon N., additional, Feng, Lei, additional, Lee, Hans Chulhee, additional, Manasanch, Elisabet Esteve, additional, Weber, Donna M., additional, Patel, Krina K., additional, Orlowski, Robert Z., additional, Neelapu, Sattva Swarup, additional, and Kwak, Larry W., additional

Published
2019
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5. Generation of a novel therapeutic peptide that depletes MDSC in tumor-bearing mice

Author

Qin, Hong, Lerman, Beatrisa, Sakamaki, Ippei, Wei, Guowei, Cha, Soungchul, Rao, Sheetal S., Qian, Jianfei, Hailemichael, Yared, Nurieva, Roza, Dwyer, Karen C., Roth, Johannes, Yi, Qing, Overwijk, Willem W., and Kwak, Larry W.

Subjects
Mice, Peptide Library, Neoplasms, Recombinant Fusion Proteins, S100 Proteins, Tumor Microenvironment, Animals, Immunoprecipitation, Myeloid Cells, Receptors, Cell Surface, Tumor Escape, Article
Abstract

Immune evasion is an emerging hallmark of cancer progression. However, functional studies to understand the role of myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment are limited by the lack of available specific cell surface markers. We adapted a competitive peptide phage display platform to identify candidate peptides binding MDSCs specifically and generated peptide-Fc fusion proteins (peptibodies). In multiple tumor models, intravenous peptibody injection completely depleted blood, splenic and intratumoral MDSCs in tumor-bearing mice without affecting proinflammatory immune cell types, such as dendritic cells. Whereas control Gr-1-specific antibody primarily depleted granulocytic MDSCs, peptibodies depleted both granulocytic and monocytic MDSC subsets. Peptibody treatment was associated with inhibition of tumor growth in vivo, which was superior to that achieved with Gr-1-specific antibody. Immunoprecipitation of MDSC membrane proteins identified S100 family proteins as candidate targets. Our strategy may be useful to identify new diagnostic and therapeutic surface targets on rare cell subtypes, including human MDSCs.

Published
2014

6. Randomized Phase II Trial of Combination Idiotype Vaccine and Anti-CD3/Anti-CD28 Costimulated Autologous T Cells in Patients with Multiple Myeloma Post-Autotransplantation

Author

Qazilbash, Muzaffar H., primary, Stadtmauer, Edward A, additional, Baladandayuthapani, Veera, additional, Lin, Heather, additional, Tross, Beryl M., additional, Honhar, Medhavi, additional, Cha, Soung-Chul, additional, Kim, Kunhwa, additional, Rao, Sheetal S, additional, Popescu, Michael, additional, Shah, Nina, additional, Bashir, Qaiser, additional, Patel, Krina, additional, Shpall, Elizabeth J., additional, Weber, Donna M., additional, Thomas, Sheeba K., additional, Shah, Jatin J., additional, Orlowski, Robert Z., additional, Kerr, Naseem DS, additional, Garfall, Alfred L., additional, Cohen, Adam D., additional, Dengel, Karen, additional, June, Carl H, additional, Champlin, Richard E., additional, and Kwak, Larry, additional

Published
2016
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