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1. Global prevalence and characteristics of infections and clinical outcomes in hospitalised patients with cirrhosis: a prospective cohort study for the CLEARED Consortium

Author

Kumar, Shiva, Gadano, Adrián, Marciano, Sebastián, Tudehope, Fiona, Prudence, Alexander, Gibson, Robert, Zekry, Amany, Doyle, Adam, Si, Hooi Ling, Kim, Yu Sung, Gofton, Cameron, Riordan, Stephen, MacQuillan, Gerry, Al-Tamimi, Hala, Michalczuk, Matheus, Farias, Alberto, Zitelli, Patricia, Pereira, Gustavo, Victor, Livia, Bera, Chinmay, Faisal, Nabiha, Dahiya, Monica, Tandon, Puneeta, Lohoues, Marie Jeanne, Lah, Ponan Claude Regis, Benítez, Carlos, Arrese, Marco, Guan, Jing, Xian, Yongchao, Zhu, Chuanwu, Wang, Yingling, Su, Man, Su, Minghua, Wang, Xinrui, Gao, Yanhang, Peng, Feng, Jiang, Yongfang, Zhao, Caiyan, Wang, Wei, Yin, Dedong, Wang, Lei, Lu, Mingqin, Cai, Yijing, Guo, Feng, Wang, Xiaozhong, Zhang, Ningping, Zhang, Wanqin, Dong, Fuchen, Li, Hai, Liu, Jing, Zheng, Xin, Tang, Hong, Yan, Libo, Xu, Bin, Wei, Linlin, Xu, Zhen, Gao, Zhiliang, Gao, Haibing, Lin, Minghua, Rao, Qunfang, Wu, Xiaoping, Li, Beiling, Chen, Jinjun, Liu, Chenghai, Zhang, Yanyun, Deng, Huan, Hu, Peng, Wang, Jian, Li, Jie, Bettinger, Dominik, Schultheiß, Michael, Belimi, Hibat Allah, Debzi, Nabil, Mostafa, Alaa, Fouad, Yasser, Fisseha, Henok, Venkatachalapathy, Suresh Vasan, Aravinthan, Aloysious D, Rajoriya, Neil, Faulkes, Rosemary, Leith, Damien, Forrest, Ewan, Danielle, Adebayo, Kennedy, James, Yung, Diana, Alexopoulou, Alexandra, Mani, Iliana, Fung, James, Katchman, Helena, Rabinowich, Liane, Jhaveri, Ajay, Nagral, Aabha, Kulkarni, Anand, Sharma, Mithun, Sarin, Shiv K, Goel, Ashish, Eapen, C E, Duseja, Ajay, Gandotra, Akash, Saraya, Anoop, yegurla, Jatin, Jothimani, Dinesh, Rela, Mohammad, Arora, Anil, Kumar, Ashish, Roy, Akash, Dhiman, R K, Anand, A C, Praharaj, Dibyalochan, Cabrera, Araceli Bravo, Hueso, Sarai Gonzalez, Hérnandez, José Luis Pérez, Gutierrez, Oscar Morales, Ramos-Pineda, Abraham, Zazueta, Godolfino Miranda, Barradas, Mauricio Castillo, Made, Lilian Torres, Velazquez, Rene Male, Félix-Tellez, Francisco, Velasco, José Antonio Velarde-Ruiz, Cordova-Gallardo, Jacqueline, Rajaram, Ruveena, Afendi, Nik Arsyad Nik Muhamad, Nyam, David P, Okeke, Edith N, Allam, Dalia, Patwa, Yashwi Haresh Kumar, Tan, Hiang Keat, Lun, Liou Wei, Ho, Wei Ling Danielle, Wong, Yu Jun, Thanapirom, Kessarin, Teerasarntipan, Tongluk, Haktaniyan, Busra, Gunduz, Feyza, Aslan, Rahmi, Yildirim, Abdullah Emre, Barutcu, Sezgin, Uysal, Alper, Karasu, Zeki, Ucbilek, Enver, Kosay, Tolga, Dinçer, Dinç, Adanır, Haydar, Albhaisi, Somaya, Fallahadeh, Mohammad Amin, Asrani, Sumeet, Reddy, K Rajender, Shaw, Jawaid, Vargas, Hugo, Filipek, Natalia, Biggins, Scott W, Thuluvath, Paul, Sheshadri, Somya, Wegermann, Kara, Kappus, Matthew, Keaveny, Andrew, Rojo, Andres, Negrillo, Ricardo Cabello, Verna, Elizabeth, Cao, Zhujun, Wong, Florence, Choudhury, Ashok K, Kamath, Patrick S, Topazian, Mark, Torre, Aldo, Hayes, Peter C, George, Jacob, Idilman, Ramazan, Seto, Wai-Kay, Desalegn, Hailemichael, Alvares-da-Silva, Mario Reis, Bush, Brian J, Thacker, Leroy R, Xie, Qing, and Bajaj, Jasmohan S

Published
2024
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2. FRI-088 Patterns and predictors of postacute discharge location other than home in a global cohort of 3, 678 patients hospitalized with cirrhosis

Author

Seto, Wai-Kay, primary, Xie, Qing, additional, Kumar Choudhury, Ashok, additional, Kamath, Patrick S., additional, Topazian, Mark, additional, Hayes, Peter, additional, Torre, Aldo, additional, Desalegn, Hailemichael, additional, Idilman, Ramazan, additional, Cao, Zhujun, additional, Álvares-da-Silva, Mario, additional, George, Jacob, additional, Wong, Florence, additional, Bush, Brian, additional, Thacker, Leroy, additional, Kumar Sarin, Shiv, additional, Mani, Iliana, additional, Dincer, Dinc, additional, van Doorn, Diederick, additional, Sonavane, Amey, additional, Amin Fallahzadeh, Mohammad, additional, Wei, Linlin, additional, Bravo Cabrera, Araceli, additional, Goel, Ashish, additional, Ponan Claude Regis Lah, Ponan, additional, Kumar, Shiva, additional, Jun Wong, Yu, additional, Jothimani, Dinesh, additional, Robert Kappus, Matthew, additional, Emre Yıldırım, Abdullah, additional, H Forrest, Ewan, additional, Félix Tellez, Francisco, additional, Momoyo Zitelli, Patricia, additional, Barbero, Manuel, additional, Luis Pérez-Hernández, José, additional, Marciano, Sebastián, additional, Malé Velazquez, René, additional, Jhaveri, Ajay, additional, Gibson, Robert, additional, Chandra Anand, Anil, additional, Kayes, Tahrima, additional, Gunduz, Feyza, additional, Bayne, David, additional, Lin, Minghua, additional, Ucbilek, Enver, additional, Debzi, Nabil, additional, Wang, Jian, additional, Haresh Kumar Patwa, Yashwi, additional, Kumar Duseja, Ajay, additional, Arrese, Marco, additional, Faulkes, Rosemary, additional, Kennedy, James, additional, Sung Kim, Yu, additional, Krishan Dhiman, Radha, additional, Li, Hai, additional, Yin, Dedong, additional, Zhang, Yanyun, additional, MacQuillan, Gerry, additional, Kumar, Ashish, additional, Katchman, Helena, additional, Wang, Yingling, additional, Rao, Qunfang, additional, Cai, Yijing, additional, Wu, Liyang, additional, Jiang, Yongfang, additional, Xu, Zhen, additional, Xian, Yongchao, additional, Bettinger, Dominik, additional, Dahiya, Monica, additional, Faisal, Nabiha, additional, Rojo Andres, Duarte, additional, Filipek, Natalia, additional, Tudehope, Fiona, additional, Zhang, Wanqin, additional, and Bajaj, Jasmohan, additional

Published
2024
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3. Plasminogen as a prognostic biomarker for HBV-related acute-on-chronic liver failure

Author

Wu, Daxian, Zhang, Sainan, Xie, Zhongyang, Chen, Ermei, Rao, Qunfang, Liu, Xiaoli, Huang, Kaizhou, Yang, Jing, Xiao, Lanlan, Ji, Feiyang, Jiang, Zhengyi, Zhao, Yalei, Ouyang, Xiaoxi, Zhu, Danhua, Dai, Xiahong, Hou, Zhouhua, Liu, Bingjie, Deng, Binbin, Zhou, Ning, Gao, Hainv, Sun, Zeyu, and Li, Lanjuan

Subjects
Analysis, Health aspects, Mortality -- China, Liver failure -- Health aspects -- Analysis, Thyrotropin -- Health aspects -- Analysis, Medical research -- Analysis -- Health aspects, Fibrinolytic agents -- Health aspects -- Analysis, Hepatitis B -- Analysis -- Health aspects, Bilirubin -- Analysis -- Health aspects, Hepatitis, Hormones, Liver diseases, Biological markers, Proteomics, Liver encephalopathy, Diseases, Encephalopathy, Technology, Pituitary hormones
Abstract

Introduction Acute-on-chronic liver failure (ACLF) is a life-threatening clinical condition that occurs in patients with preexisting chronic liver disease (CLD). It can progress rapidly and has a mortality rate of [...], BACKGROUND. HBV-related acute-on-chronic liver failure (HBV-ACLF) is hallmarked by high short-term mortality rates, calling for accurate prognostic biomarkers for initial risk stratification. METHODS. Three tandem mass tag-labeled (TMT-labeled) quantitative proteomic studies were performed on 10 patients with HBV-related acute hepatic decompensation and on 20 patients with HBV-ACLF. Candidate biomarkers were preliminarily verified in a cross-sectional cohort (n = 144) and further confirmed in 2 prospective cohorts (n = 207 and n = 148). RESULTS. Plasminogen, a potential prognostic biomarker for HBV-ACLF, was identified by TMT quantitative proteomics and preliminarily verified in the cross-sectional cohort. Further validation with a prospective cohort (n = 207) showed that plasminogen levels at admission were significantly lower (P < 0.001) in HBV-ACLF nonsurvivors than in survivors. The cumulative survival duration of patients with high plasminogen levels was significantly longer (P < 0.001) than that of patients with low plasminogen levels. During hospitalization, plasminogen levels significantly decreased (P = 0.008) in the deterioration group but significantly increased (P < 0.001) in the improvement group. Additionally, plasminogen levels gradually increased in survivors but gradually decreased in nonsurvivors. The P5 score, a prognostic panel incorporating plasminogen levels, hepatic encephalopathy occurrence, age, international normalized ratio (INR), and total bilirubin, was significantly superior to the Child-Pugh, Model for End-stage Liver Disease (MELD), Chronic Liver Failure Consortium ACLF (CLIF-C ACLF), Chinese Group on the Study of Severe Hepatitis B (COSSH), and HINT (a prognostic score based on hepatic encephalopathy occurrence, INR, neutrophil count, and thyroid-stimulating hormone) scores (all P < 0.05). The performances of the plasminogen level and P5 score were validated in a second multicenter, prospective cohort (n = 148). CONCLUSIONS. Plasminogen is a promising prognostic biomarker for HBV-ACLF, and sequential plasminogen measurements could profile the clinical course of HBV-ACLF. P5 is a high-performance prognostic score for HBV-ACLF. FUNDING. The National Key Research and Development Program (2017YFC1200204); the National Natural Science Foundation of China (81400589, 81600497); the Foundation for Innovative Research Groups of the National Natural Science Foundation of China (81121002); the Chinese High-Tech Research and Development Programs (2012AA020204); the National S&T Major Project (2012ZX10002004); and the Zhejiang Provincial Medicine and Health Science and Technology Project (2016147735).

Published
2020
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4. Global prevalence and characteristics of infections and clinical outcomes in hospitalised patients with cirrhosis: a prospective cohort study for the CLEARED Consortium

Author

Cao, Zhujun, Wong, Florence, Choudhury, Ashok K, Kamath, Patrick S, Topazian, Mark, Torre, Aldo, Hayes, Peter C, George, Jacob, Idilman, Ramazan, Seto, Wai-Kay, Desalegn, Hailemichael, Alvares-da-Silva, Mario Reis, Bush, Brian J, Thacker, Leroy R, Xie, Qing, Bajaj, Jasmohan S, Kumar, Shiva, Gadano, Adrián, Marciano, Sebastián, Tudehope, Fiona, Prudence, Alexander, Gibson, Robert, Zekry, Amany, Doyle, Adam, Si, Hooi Ling, Kim, Yu Sung, Gofton, Cameron, Riordan, Stephen, MacQuillan, Gerry, Al-Tamimi, Hala, Michalczuk, Matheus, Farias, Alberto, Zitelli, Patricia, Pereira, Gustavo, Victor, Livia, Bera, Chinmay, Faisal, Nabiha, Dahiya, Monica, Tandon, Puneeta, Lohoues, Marie Jeanne, Lah, Ponan Claude Regis, Benítez, Carlos, Arrese, Marco, Guan, Jing, Xian, Yongchao, Zhu, Chuanwu, Wang, Yingling, Su, Man, Su, Minghua, Wang, Xinrui, Gao, Yanhang, Peng, Feng, Jiang, Yongfang, Zhao, Caiyan, Wang, Wei, Yin, Dedong, Wang, Lei, Lu, Mingqin, Cai, Yijing, Guo, Feng, Wang, Xiaozhong, Zhang, Ningping, Zhang, Wanqin, Dong, Fuchen, Li, Hai, Liu, Jing, Zheng, Xin, Tang, Hong, Yan, Libo, Xu, Bin, Wei, Linlin, Xu, Zhen, Gao, Zhiliang, Gao, Haibing, Lin, Minghua, Rao, Qunfang, Wu, Xiaoping, Li, Beiling, Chen, Jinjun, Liu, Chenghai, Zhang, Yanyun, Deng, Huan, Hu, Peng, Wang, Jian, Li, Jie, Bettinger, Dominik, Schultheiß, Michael, Belimi, Hibat Allah, Debzi, Nabil, Mostafa, Alaa, Fouad, Yasser, Fisseha, Henok, Venkatachalapathy, Suresh Vasan, Aravinthan, Aloysious D, Rajoriya, Neil, Faulkes, Rosemary, Leith, Damien, Forrest, Ewan, Danielle, Adebayo, Kennedy, James, Yung, Diana, Alexopoulou, Alexandra, Mani, Iliana, Fung, James, Katchman, Helena, Rabinowich, Liane, Jhaveri, Ajay, Nagral, Aabha, Kulkarni, Anand, Sharma, Mithun, Sarin, Shiv K, Goel, Ashish, Eapen, C E, Duseja, Ajay, Gandotra, Akash, Saraya, Anoop, yegurla, Jatin, Jothimani, Dinesh, Rela, Mohammad, Arora, Anil, Kumar, Ashish, Roy, Akash, Dhiman, R K, Anand, A C, Praharaj, Dibyalochan, Cabrera, Araceli Bravo, Hueso, Sarai Gonzalez, Hérnandez, José Luis Pérez, Gutierrez, Oscar Morales, Ramos-Pineda, Abraham, Zazueta, Godolfino Miranda, Barradas, Mauricio Castillo, Made, Lilian Torres, Velazquez, Rene Male, Félix-Tellez, Francisco, Velasco, José Antonio Velarde-Ruiz, Cordova-Gallardo, Jacqueline, Rajaram, Ruveena, Afendi, Nik Arsyad Nik Muhamad, Nyam, David P, Okeke, Edith N, Allam, Dalia, Patwa, Yashwi Haresh Kumar, Tan, Hiang Keat, Lun, Liou Wei, Ho, Wei Ling Danielle, Wong, Yu Jun, Thanapirom, Kessarin, Teerasarntipan, Tongluk, Haktaniyan, Busra, Gunduz, Feyza, Aslan, Rahmi, Yildirim, Abdullah Emre, Barutcu, Sezgin, Uysal, Alper, Karasu, Zeki, Ucbilek, Enver, Kosay, Tolga, Dinçer, Dinç, Adanır, Haydar, Albhaisi, Somaya, Fallahadeh, Mohammad Amin, Asrani, Sumeet, Reddy, K Rajender, Shaw, Jawaid, Vargas, Hugo, Filipek, Natalia, Biggins, Scott W, Thuluvath, Paul, Sheshadri, Somya, Wegermann, Kara, Kappus, Matthew, Keaveny, Andrew, Rojo, Andres, Negrillo, Ricardo Cabello, and Verna, Elizabeth

Abstract

Infections have a poor prognosis in inpatients with cirrhosis. We aimed to determine regional variations in infections and their association with clinical outcomes in a global cohort of inpatients with cirrhosis.

Published
2024
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7. Weighted thyroid‐stimulating hormone disturbance in prognosis of hepatitis B virus‐related acute‐on‐chronic liver failure.

Author

Tu, Yasi, Ji, Feiyang, Yang, Jing, Rao, Qunfang, Wu, Haiquan, Xie, Zhongyang, Zhang, Sainan, Hou, Zhouhua, and Wu, Daxian

Subjects
LIVER failure, HEPATITIS B, PROBABILITY density function, THYROID hormones, HYPOTHALAMIC-pituitary-thyroid axis, CHRONIC hepatitis B, CONGENITAL hypothyroidism
Abstract

Aim: To weight the prognostic value of thyroid hormones in catastrophic acute‐on‐chronic liver failure (ACLF). Methods: A retrospective cohort (n = 635) and two prospective cohorts (n = 353, and 198) were enrolled in this study. The performance of a novel developed prognostic score was assessed from aspects of reliability, discrimination, and clinical net benefit. Results: Thyroid‐stimulating hormone (TSH) was identified to have the most potential as a prognostic predictor for hepatitis B virus‐related ACLF among thyroid hormones. The novel score (modified chronic liver failure–organ failure score [mCLIF‐OFs]) was developed with weighted TSH and other scored organs in the CLIF‐OFs using the retrospective cohort (n = 635). The predicted risk and observed probabilities of death were comparable across the deciles of mCLIF‐OFs (Hosmer–Lemeshow χ2 = 4.28, p = 0.83; Brier scaled = 11.9). The C‐index of mCLIF‐OFs (0.885 [0.883–0.887]) for 30‐day mortality was significantly higher than that of the CLIF‐OFs, chronic liver failure–sequential organ failure assessment score (CLIF‐SOFAs), CLIF‐C ACLFs, Model of End‐stage Liver Disease (MELD), and Child–Pugh (all p < 0.001). The absolute improvements of prediction error rates of the mCLIF‐OFs compared to the above five scores were from 19.0% to 61.1%. After the analysis of probability density function, the mCLIF‐OFs showed the least overlapping coefficients (27.9%) among the above prognostic scores. Additionally, the mCLIF‐OFs showed greater net benefit than the above five prognostic scores over a wide range of risk threshold of death. Similar results were validated in two prospective ACLF cohorts with HBV and non‐HBV etiologies. Conclusion: Weighted TSH portended the outcome of ACLF patients, which could be treated as a "damaged organ" of the hypothalamic–pituitary–thyroid axis. The novel mCLIF‐OFs is a reliable prognostic score with better discrimination power and clinical net benefit than CLIF‐OFs, CLIF‐SOFAs, CLIF‐C ACLFs, MELD, and Child–Pugh. [ABSTRACT FROM AUTHOR]

Published
2024
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8. A novel heterozygous deletion in ABCB4 gene in a Chinese family with intrahepatic cholestasis of pregnancy, neonatal hyperbilirubinemia, and cholelithiasis: Case reports and literature review.

Author

Zheng, Yang, Rao, Qunfang, Han, Yiru, and He, Jianqin

Subjects
*NEONATAL jaundice, *GENE families, *PREGNANCY, *CHOLESTASIS, *MEDICAL personnel
Abstract

Background: ABCB4 gene (OMIM *171060) variant is associated with a wide clinical spectrum of hepatobiliary diseases, including familial intrahepatic cholestasis of pregnancy (ICP), progressive familial intrahepatic cholestasis type 3 (PFIC3), and neonatal hyperbilirubinemia due to impaired protection of the bile duct. The majority of reported cases, however, were missense or nonsense variants, with few deletion variant findings in the Chinese population. Method: We performed whole genome sequencing and confirmed it with Sanger sequencing of the proband infant and his families. Clinical courses and laboratory results were documented and collected from the proband infant and his mother. We also reviewed other published cases related to genetic variants in ABCB4 in the Chinese population. Results: A 26‐year‐old Chinese female (II.2) who had recurrent intrahepatic cholestasis of pregnancy and her 49‐day‐old son (III.4) who had hyperbilirubinemia, both presented with extremely elevated total bile acid, cholestatic dominant pattern liver function abnormalities. They were able to stay relatively stable with mild pruritus on ursodeoxycholic acid treatment. After ruling out other possibilities, genetic sequencing revealed a diagnosis of heterozygous deletion variant NM_018849.3:c.1452_1454del (NP_061337.1:p.Thr485del) in ABCB4, which was not reported before, in the symptomatic mother (II.2), index patient (III.4), and the symptomatic grandmother (I.2). This variant resulted in clinical spectrums of ICP, neonatal hyperbilirubinemia, and cholelithiasis in our pedigree. Conclusion: We reported a novel heterozygous deletion variant of the ABCB4 gene in a Chinese family, as well as a literature review of ABCB4‐related disorders. We aim to facilitate healthcare professionals to better understand genetic factors as an uncommon cause of hepatobiliary diseases, as well as improve therapeutic strategies in challenging clinical situations such as pregnancy and neonatal care. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Delayed Hospitalization Tends to Cause More Extrapulmonary Organ Injures for Patients with Coronavirus Disease 2019

Author

Wu, Daxian, primary, Huang, Jiansheng, additional, Xiao, Lushan, additional, Rao, Qunfang, additional, Ge, Shanfei, additional, He, Ying, additional, Cheng, Xiaoyu, additional, Yang, Qian, additional, Lai, Lingling, additional, Rao, Xi, additional, He, Yulin, additional, Wu, Xiaoping, additional, Zhang, Wei, additional, and Zhang, Wenfeng, additional

Published
2020
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16. HINT: a novel prognostic model for patients with hepatitis B virus‐related acute‐on‐chronic liver failure

Author

Wu, Daxian, primary, Sun, Zeyu, additional, Liu, Xiaoli, additional, Rao, Qunfang, additional, Chen, Wenqian, additional, Wang, Jie, additional, Xie, Zhongyang, additional, Zhang, Sainan, additional, Jiang, Zhengyi, additional, Chen, Er'mei, additional, Huang, Kaizhou, additional, Hu, Chenxia, additional, Zhang, Xiaoqian, additional, Wu, Jie, additional, Zhang, Yimin, additional, Gao, Hainv, additional, and Li, Lanjuan, additional

Published
2018
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17. Development and validation of a novel score for fibrosis staging in patients with chronic hepatitis B

Author

Wu, Daxian, primary, Rao, Qunfang, additional, Chen, Wenqian, additional, Ji, Feiyang, additional, Xie, Zhongyang, additional, Huang, Kaizhou, additional, Chen, Er'mei, additional, Zhao, Yalei, additional, Ouyang, Xiaoxi, additional, Zhang, Sainan, additional, Jiang, Zhengyi, additional, Zhang, Lingjian, additional, Xu, Linjie, additional, Gao, Hainv, additional, and Li, Lanjuan, additional

Published
2018
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18. Hemorrhagic fever with renal syndrome presenting as leukemoid reaction and hemophagocytic lymphohistiocytosis.

Author

Rao, Qunfang, Luo, Lin, Gao, Li, Xiong, Wanyin, Nie, Qinqin, and Wu, Daxian

Subjects
HEMORRHAGIC fever with renal syndrome, DENGUE hemorrhagic fever, HEMOPHAGOCYTIC lymphohistiocytosis, MEDICAL personnel, REGULATORY T cells, DIAGNOSIS
Abstract

Hemorrhagic fever with renal syndrome (HFRS) is a worldwide rodent-borne zoonosis epidemic characterized by fever, hypotension, hemorrhage, and acute kidney injury.1 Here, we report the first HFRS case presenting as leukemoid reaction (LR) and hemophagocytic lymphohistiocytosis (HLH). Decreased perforin expression resulting in diminished natural killer (NK) cell activity plays a crucial role in the pathogenesis of HLH.2 However, the NK cell dysfunction is not intrinsic but acquired for patients with secondary HLH. [Extracted from the article]

Published
2022
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