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20 results on '"Rao, Estella"'

1. Extracellular vesicles from the microalga Tetraselmis chuii are biocompatible and exhibit unique bone tropism along with antioxidant and anti-inflammatory properties

Author

Adamo, Giorgia, Santonicola, Pamela, Picciotto, Sabrina, Gargano, Paola, Nicosia, Aldo, Longo, Valeria, Aloi, Noemi, Romancino, Daniele P., Paterna, Angela, Rao, Estella, Raccosta, Samuele, Noto, Rosina, Salamone, Monica, Deidda, Irene, Costa, Salvatore, Di Sano, Caterina, Zampi, Giuseppina, Morsbach, Svenja, Landfester, Katharina, Colombo, Paolo, Wei, Mingxing, Bergese, Paolo, Touzet, Nicolas, Manno, Mauro, Di Schiavi, Elia, and Bongiovanni, Antonella

Published
2024
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2. Comparison between iMSD and 2D-pCF analysis for molecular motion studies on in vivo cells: The case of the epidermal growth factor receptor

Author

Malacrida, Leonel, Rao, Estella, and Gratton, Enrico

Subjects
Biochemistry and Cell Biology, Biological Sciences, Algorithms, Animals, CHO Cells, Cricetulus, Diffusion, ErbB Receptors, Green Fluorescent Proteins, Image Processing, Computer-Assisted, Intravital Microscopy, Microscopy, Fluorescence, Models, Chemical, Fluorescence fluctuation spectroscopy, Diffusion anisotropy, Barrier to diffusion, Connectivity maps
Abstract

Image correlation analysis has evolved to become a valuable method of analysis of the diffusional motion of molecules in every points of a live cell. Here we compare the iMSD and the 2D-pCF approaches that provide complementary information. The iMSD method provides the law of diffusion and it requires spatial averaging over a small region of the cell. The 2D-pCF does not require spatial averaging and it gives information about obstacles for diffusion at pixel resolution. We show the analysis of the same set of data by the two methods to emphasize that both methods could be needed to have a comprehensive understanding of the molecular diffusional flow in a live cell.

Published
2018

4. αS1-Casein-Loaded Proteo-liposomes as Potential Inhibitors in Amyloid Fibrillogenesis: In Vivo Effects on a C. elegans Model of Alzheimer’s Disease

Author

Paterna, Angela, primary, Santonicola, Pamela, additional, Di Prima, Giulia, additional, Rao, Estella, additional, Raccosta, Samuele, additional, Zampi, Giuseppina, additional, Russo, Claudio, additional, Moran, Oscar, additional, Manno, Mauro, additional, Di Schiavi, Elia, additional, Librizzi, Fabio, additional, and Carrotta, Rita, additional

Published
2023
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5. Microalgae as a novel biofactory for biocompatible and bioactive extracellular vesicles

Author

Bongiovanni, Antonella, primary, Adamo, Giorgia, additional, Santonicola, Pamela, additional, Picciotto, Sabrina, additional, Gargano, Paola, additional, Nicosia, Aldo, additional, Longo, Valeria, additional, Aloi, Noemi, additional, Romancino, Daniele, additional, Paterna, Angela, additional, Rao, Estella, additional, Raccosta, Samuele, additional, Noto, Rosina, additional, Salamone, Monica, additional, Costa, Salvatore, additional, Sano, Caterina Di, additional, Zampi, Giuseppina, additional, colombo, Paolo, additional, Wei, Mingxing, additional, Touzet, Nicolas, additional, Manno, Mauro, additional, and Schiavi, Elia Di, additional

Published
2023
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6. Microalgae as a novel biofactory for biocompatible and bioactive extracellular vesicles

Author

Adamo, Giorgia, primary, Santonicola, Pamela, additional, Picciotto, Sabrina, additional, Gargano, Paola, additional, Nicosia, Aldo, additional, Longo, Valeria, additional, Aloi, Noemi, additional, Romancino, Daniele Paolo, additional, Paterna, Angela, additional, Rao, Estella, additional, Raccosta, Samuele, additional, Noto, Rosina, additional, Salamone, Monica, additional, Costa, Salvatore, additional, Di Sano, Caterina, additional, Zampi, Giuseppina, additional, Colombo, Paolo, additional, Wei, Mingxing, additional, Touzet, Nicolas, additional, Manno, Mauro, additional, Di Schiavi, Elia, additional, and Bongiovanni, Antonella, additional

Published
2023
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8. Extracellular Vesicles From Microalgae: Uptake Studies in Human Cells and Caenorhabditis elegans

Author

Picciotto, Sabrina, primary, Santonicola, Pamela, additional, Paterna, Angela, additional, Rao, Estella, additional, Raccosta, Samuele, additional, Romancino, Daniele Paolo, additional, Noto, Rosina, additional, Touzet, Nicolas, additional, Manno, Mauro, additional, Di Schiavi, Elia, additional, Bongiovanni, Antonella, additional, and Adamo, Giorgia, additional

Published
2022
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10. Nanoalgosomes: Introducing extracellular vesicles produced by microalgae

Author

Adamo, Giorgia, primary, Fierli, David, additional, Romancino, Daniele P., additional, Picciotto, Sabrina, additional, Barone, Maria E., additional, Aranyos, Anita, additional, Božič, Darja, additional, Morsbach, Svenja, additional, Raccosta, Samuele, additional, Stanly, Christopher, additional, Paganini, Carolina, additional, Gai, Meiyu, additional, Cusimano, Antonella, additional, Martorana, Vincenzo, additional, Noto, Rosina, additional, Carrotta, Rita, additional, Librizzi, Fabio, additional, Randazzo, Loredana, additional, Parkes, Rachel, additional, Capasso Palmiero, Umberto, additional, Rao, Estella, additional, Paterna, Angela, additional, Santonicola, Pamela, additional, Iglič, Ales, additional, Corcuera, Laura, additional, Kisslinger, Annamaria, additional, Schiavi, Elia Di, additional, Liguori, Giovanna L., additional, Landfester, Katharina, additional, Kralj‐Iglič, Veronika, additional, Arosio, Paolo, additional, Pocsfalvi, Gabriella, additional, Touzet, Nicolas, additional, Manno, Mauro, additional, and Bongiovanni, Antonella, additional

Published
2021
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11. Agarose/κ-carrageenan-based hydrogel film enriched with natural plant extracts for the treatment of cutaneous wounds

Author

Ditta, Lorena Anna, primary, Rao, Estella, additional, Provenzano, Fiorenza, additional, Sánchez, Jesús Lozano, additional, Santonocito, Radha, additional, Passantino, Rosa, additional, Costa, Maria Assunta, additional, Sabatino, Maria Antonietta, additional, Dispenza, Clelia, additional, Giacomazza, Daniela, additional, San Biagio, Pier Luigi, additional, and Lapasin, Romano, additional

Published
2020
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13. Water Extract of Cryphaea heteromalla (Hedw.) D. Mohr Bryophyte as a Natural Powerful Source of Biologically Active Compounds

Author

Provenzano, Fiorenza, primary, Sánchez, Jesús Lozano, additional, Rao, Estella, additional, Santonocito, Radha, additional, Ditta, Lorena Anna, additional, Borrás Linares, Isabel, additional, Passantino, Rosa, additional, Campisi, Patrizia, additional, Dia, Maria Giovanna, additional, Costa, Maria Assunta, additional, Segura-Carretero, Antonio, additional, San Biagio, Pier Luigi, additional, and Giacomazza, Daniela, additional

Published
2019
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14. Recombinant mussel protein Pvfp-5β: A potential tissue bioadhesive

Author

Santonocito, Radha, primary, Venturella, Francesca, additional, Dal Piaz, Fabrizio, additional, Morando, Maria Agnese, additional, Provenzano, Alessia, additional, Rao, Estella, additional, Costa, Maria Assunta, additional, Bulone, Donatella, additional, San Biagio, Pier Luigi, additional, Giacomazza, Daniela, additional, Sicorello, Alessandro, additional, Alfano, Caterina, additional, Passantino, Rosa, additional, and Pastore, Annalisa, additional

Published
2019
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17. Stirring effects in amyloid fibril formation

Author

Rao, Estella, VETRI, Valeria, MILITELLO, Valeria, LEONE, Maurizio, Foderà,V, Rao,E, Vetri,V, Foderà,V, Militello,V, and Leone M

Subjects
Amyloid, Shear force, Spectroscopy
Published
2014

19. Characterization Of Casein-Loaded Proteoliposomes, Potential Inhibitors In Amyloid Fibrillogenesis

Author

Paterna Angela, Santonicola Pamela, Di Prima Giulia, Rao Estella, Raccosta Samuele, Moran Oscar, Librizzi Fabio, Manno Mauro, Di Schiavi Elia, Carrotta Rita, and Paterna Angela, Santonicola Pamela, Di Prima Giulia, Rao Estella, Raccosta Samuele, Moran Oscar, Librizzi Fabio, Manno Mauro, Di Schiavi Elia, Carrotta Rita

Subjects
Settore CHIM/09 - Farmaceutico Tecnologico Applicativo, Casein, liposomes, proteoliposomes, alzheimer's, C elegans in vivo model

20. α S1 -Casein-Loaded Proteo-liposomes as Potential Inhibitors in Amyloid Fibrillogenesis: In Vivo Effects on a C. elegans Model of Alzheimer's Disease.

Author

Paterna A, Santonicola P, Di Prima G, Rao E, Raccosta S, Zampi G, Russo C, Moran O, Manno M, Di Schiavi E, Librizzi F, and Carrotta R

Subjects
Animals, Humans, Amyloid beta-Peptides metabolism, Liposomes, Caseins pharmacology, Caenorhabditis elegans, Amyloid chemistry, Alzheimer Disease drug therapy, Alzheimer Disease metabolism
Abstract

According to the amyloid hypothesis, in the early phases of Alzheimer's disease (AD), small soluble prefibrillar aggregates of the amyloid β-peptide (Aβ) interact with neuronal membranes, causing neural impairment. Such highly reactive and toxic species form spontaneously and transiently in the amyloid building pathway. A therapeutic strategy consists of the recruitment of these intermediates, thus preventing aberrant interaction with membrane components (lipids and receptors), which in turn may trigger a cascade of cellular disequilibria. Milk α s1 -Casein is an intrinsically disordered protein that is able to inhibit Aβ amyloid aggregation in vitro , by sequestering transient species. In order to test α s1 -Casein as an inhibitor for the treatment of AD, it needs to be delivered in the place of action. Here, we demonstrate the use of large unilamellar vesicles (LUVs) as suitable nanocarriers for α s1 -Casein. Proteo-LUVs were prepared and characterized by different biophysical techniques, such as multiangle light scattering, atomic force imaging, and small-angle X-ray scattering; α s1 -Casein loading was quantified by a fluorescence assay. We demonstrated on a C. elegans AD model the effectiveness of the proposed delivery strategy in vivo . Proteo-LUVs allow efficient administration of the protein, exerting a positive functional readout at very low doses while avoiding the intrinsic toxicity of α s1 -Casein. Proteo-LUVs of α s1 -Casein represent an effective proof of concept for the exploitation of partially disordered proteins as a therapeutic strategy in mild AD conditions.

Published
2023
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