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148 results on '"Ranzato, R."'

2. Prognosis of gastrointestinal stromal tumors

Author

Bertin, M, Angriman, Imerio, Scarpa, M, Mencarelli, R, Ranzato, R, Ruffolo, C., Polese, Lino, Iacobone, Maurizio, and D'Amico, Df

Subjects
Adult, Aged, 80 and over, Male, Gastrointestinal Stromal Tumors, Middle Aged, Prognosis, Immunohistochemistry, Sensitivity and Specificity, Survival Analysis, Proto-Oncogene Proteins c-kit, Risk Factors, Mitotic Index, Humans, Female, Aged, Retrospective Studies
Abstract

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors (GIMT) of the gut. The aim of this retrospective study is to correlate the histological risk factors with the survival of our patients operated for GIST.In our department, from 1980 to October 2003, 15 patients were operated for GIST. Their mean age was 58 years old and 8 of them were males; 10 (67%) were localized in the stomach and 5 (33%) in the small bowel. In 7 cases liver metastases were present at laparotomy and 4 of them also had peritoneal diffusion. We performed immunohistochemistry for c-Kit, SMA and S100p. Mitotic index (MI) and size neoplasm were the main pathological criteria for malignity. The patients with c-kit (CD117) positive neoplasms were divided according to NIH Consensus Conference risk class, MI, tumor size, localization, SMA or S100p presence, liver metastasis and peritoneal metastasis to compare the different 5-year survival rates. Survival analysis was performed using Kaplan-Meier method and log-rank test and a p0.05 was considered as significant.Global survival rate after 5 years was 40% and the mortality was, in all cases, due to GIST. In our experience gender, age, tumor size, localization and S100p positivity did not play any role in predicting the prognosis of GIST. On the contrary high MI and SMA positivity are significantly associated to a lower survival rate (33% vs. 86% and 39% vs. 100% at 5 years, respectively). Finally patients with metastases at laparotomy have a significantly lower 5-year survival rate (hepatic 29% vs. 100%, hepatic and peritoneal 25% us. 78%).In our experience high MI and in some cases SMA expression can be considered assessed risk factors. On the other hand, criteria of benign behavior did not completely predict the long-term clinical outcome.

Published
2007

6. Indications to esophageal endoprosthesis placement in advanced esophageal cancer

Author

Norberto, Lorenzo, Erroi, F., Marino, S., Ranzato, R., Angriman, Imerio, Donati, D., Polese, Lino, Ruffolo, C., Frego, Mauro, and D'Amico, D. F.

Subjects
esophagectomy, esophageal cancer, esophagectomy, neoadjuvant therapy, elderly patients, morbidity, mortality, survival, morbidity, esophageal cancer, neoadjuvant therapy, elderly patients, mortality, survival
Published
2002

9. Ruolo dell'Endoscopia nelle IBD

Author

Norberto, Lorenzo, Polese, Lino, Angriman, I., Erroi, F., Ranzato, R., Tosato, S., Donadi, M., and D'Amico, Davide

Published
2002

11. Mitochondrial alterations induced by the p13 protein of human T-cell leukemia virus type 1: critical role of arginin residues

Author

D'Agostino, DONNA MIA, Ranzato, R., Arrigoni, Giorgio, Cavallai, I., Belleudi, F., Torrisi, M. R., Silicbenussi, M., Ferro, T., Petronilli, V., Marin, Oriano, CHIECO BIANCHI, Luigi, Bernardi, Paolo, and Ciminale, Vincenzo

Subjects
Human T-lymphotropic virus 1, Protein Folding, Structure-Activity Relationship, Molecular Sequence Data, Retroviridae Proteins, Humans, Amino Acid Sequence, Arginine, Mitochondrial Swelling, Peptide Fragments, Protein Structure, Secondary, Membrane Potentials, Mitochondria
Abstract

Human T-cell leukemia virus type 1 encodes a number of "accessory" proteins of unclear function; one of these proteins, p13(II), is targeted to mitochondria and disrupts mitochondrial morphology. The present study was undertaken to unravel the function of p13(II) through (i) determination of its submitochondrial localization and sequences required to alter mitochondrial morphology and (ii) an assessment of the biophysical and biological properties of synthetic peptides spanning residues 9-41 (p13(9-41)), which include the amphipathic mitochondrial-targeting sequence of the protein. p13(9-41) folded into an alpha helix in micellar environments. Fractionation and immunogold labeling indicated that full-length p13(II) accumulates in the inner mitochondrial membrane. p13(9-41) induced energy-dependent swelling of isolated mitochondria by increasing inner membrane permeability to small cations (Na(+), K(+)) and released Ca(2+) from Ca(2+)-preloaded mitochondria. These effects as well as the ability of full-length p13(II) to alter mitochondrial morphology in cells required the presence of four arginines, forming the charged face of the targeting signal. The mitochondrial effects of p13(9-41) were insensitive to cyclosporin A, suggesting that full-length p13(II) might alter mitochondrial permeability through a permeability transition pore-independent mechanism, thus distinguishing it from the mitochondrial proteins Vpr and X of human immunodeficiency virus type 1 and hepatitis B virus, respectively.

Published
2002

12. LE ENDOPROTESI

Author

Norberto, Lorenzo, Erroi, F., Ranzato, R., Marino, S., and Angriman, Imerio

Published
2002

15. ENDOSCOPIC TREATMENT OF INOPERABLE ESOPHAGEAL AND CARDIAL CANCER

Author

Norberto, Lorenzo, Ranzato, R., Marino, S., Angriman, Imerio, Erroi, F., Polese, Lino, Urso, E., and D'Amico, D.

Subjects
esophagectomy, esophageal cancer, esophagectomy, neoadjuvant therapy, elderly patients, morbidity, mortality, survival, morbidity, esophageal cancer, neoadjuvant therapy, elderly patients, mortality, survival
Published
2001

16. Endoscopic Push-Through intubation of inoperable esophageal and cardial cancers

Author

Norberto, Lorenzo, Ranzato, R., Marino, S., Angriman, Imerio, Erroi, F., Polese, Lino, Urso, E., and D'Amico, D. F.

Subjects
esophagectomy, esophageal cancer, esophagectomy, neoadjuvant therapy, elderly patients, morbidity, mortality, survival, morbidity, esophageal cancer, neoadjuvant therapy, elderly patients, mortality, survival
Published
2001

26. I POLIPI DI GRANDI DIMENSIONI: TRATTAMENTO LASER

Author

Norberto, Lorenzo, Ranzato, R., Marino, S., Erroi, F. R., Angriman, I., Donadi, M., and D'Amico, D. F.

Subjects
Hematochezia, Colonoscopy, Neoplasia, Colonic neoplasia, Neoplasia, Colonic neoplasia, Colonoscopy, Hematochezia
Published
2000

28. Varici esofagee: approccio endoscopico

Author

Norberto, Lorenzo, Ranzato, R., Vella, V., Angriman, Imerio, Marino, S., Erroi, F., Donadi, M., Tosato, S. M., Termini, B., and D'Amico, D. F.

Subjects
esophageal varices
Published
2000

33. LE NEOFORMAZIONI BENIGNE DELL'ESOFAGO

Author

Norberto, Lorenzo, Ranzato, R., Erroi, F., Angriman, I., D'Erminio, A., Urso, E., Marino, S., Vella, V., and D'Amico, Davide

Published
1999

39. ENDOSCOPIC PALLIATION ON ESOPHAGEAL AND CARDIAL CANCER: ND:YAG LASER THERAPY

Author

Norberto, Lorenzo, Ranzato, R., Marino, S., Angriman, Imerio, Erroi, F., Donadi, M., Vella, V., D'Erminio, A., and D'Amico, D. F.

Subjects
esophagectomy, esophageal cancer, esophagectomy, neoadjuvant therapy, elderly patients, morbidity, mortality, survival, morbidity, esophageal cancer, neoadjuvant therapy, elderly patients, mortality, survival
Published
1998

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