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1. Role of asbestos clearance in explaining long-term risk of pleural and peritoneal cancer : a pooled analysis of cohort studies

Author

Working Group, Barone-Adesi, Francesco, Ferrante, Daniela, Chellini, Elisabetta, Merler, Enzo, Pavone, Venere, Silvestri, Stefano, Miligi, Lucia, Gorini, Giuseppe, Bressan, Vittoria, Girardi, Paolo, Ancona, Laura, Romeo, Elisa, Luberto, Ferdinando, Sala, Orietta, Scarnato, Corrado, Menegozzo, Simona, Oddone, Enrico, Tunesi, Sara, Perticaroli, Patrizia, Pettinari, Aldo, Cuccaro, Francesco, Curti, Stefania, Baldassarre, Antonio, Cena, Tiziana, Angelini, Alessia, Marinaccio, Alessandro, Mirabelli, Dario, Musti, Marina, Pirastu, Roberta, Ranucci, Alessandra, and Magnani, Corrado

Published
2019

2. Italian pool of asbestos workers cohorts : mortality trends of asbestos-related neoplasms after long time since first exposure

Author

Ferrante, Daniela, Chellini, Elisabetta, Merler, Enzo, Pavone, Venere, Silvestri, Stefano, Miligi, Lucia, Gorini, Giuseppe, Bressan, Vittoria, Girardi, Paolo, Ancona, Laura, Romeo, Elisa, Luberto, Ferdinando, Sala, Orietta, Scarnato, Corrado, Menegozzo, Simona, Oddone, Enrico, Tunesi, Sara, Perticaroli, Patrizia, Pettinari, Aldo, Cuccaro, Francesco, Mattioli, Stefano, Baldassarre, Antonio, Barone-Adesi, Francesco, Cena, Tiziana, Legittimo, Patrizia, Marinaccio, Alessandro, Mirabelli, Dario, Musti, Marina, Pirastu, Roberta, Ranucci, Alessandra, and Magnani, Corrado

Published
2017

3. Road Traffic Pollution and Childhood Leukemia: A Nationwide Case-control Study in Italy

Author

Magnani, Corrado, Mattioli, Stefano, Farioli, Andrea, Miligi, Lucia, Ranucci, Alessandra, Ferrante, Daniela, Rondelli, Roberto, Salvan, Alberto, Masera, Giuseppe, Rizzari, Carmelo, Bisanti, Luigi, Zambon, Paola, Greco Veneto, Alessandra, Cannizzaro, Santina, Gafà, Lorenzo, Luzzatto, Lia Lidia, Benvenuti, Alessandra, Michelozzi, Paola, Kirchmayer, Ursula, Cocco, Pierluigi, Galassi, Claudia, Celentano, Egidio, Guarino, Erni, Assennato, Giorgio, de Nichilo, Gigliola, Merlo, Domenico Franco, Bocchini, Vittorio, Mosciatti, Paola, Minelli, Liliana, Chiavarini, Manuela, Cuttini, Marina, Casotto, Veronica, Torregrossa, Maria Valeria, Valenti, Rosaria Maria, Forastiere, Francesco, Haupt, Riccardo, Lagorio, Susanna, Risica, Serena, Polichetti, Alessandro, Bochicchio, Francesco, Nuccetelli, Cristina, Biddau, Pierfranco, Aricò, Maurizio, DeSalvo, Gian Luca, Locatelli, Franco, Pession, Andrea, Varotto, Stefania, Poggi, Vincenzo, Massaglia, Pia, Monetti, Daniele, Targhetta, Roberto, Bernini, Gabriella, Pannelli, Franco, Sampietro, Giuseppe, Schilirò, Gino, Pulsoni, Alessandro, Parodi, Stefano, Badaloni, Chiara, and Cesaroni, Giulia

Published
2016
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4. Formaldehyde and Acetaldehyde Exposure in “Non-Traditional” Occupational Sectors: Bakeries and Pastry Producers

Author

Miligi, Lucia, primary, Piro, Sara, additional, Airoldi, Chiara, additional, Di Rico, Renato, additional, Ricci, Raffaella, additional, Paredes Alpaca, Rudy Ivan, additional, De Pasquale, Fabrizio, additional, Veraldi, Angela, additional, Ranucci, Alessandra, additional, Massari, Stefania, additional, Marinaccio, Alessandro, additional, Stoppa, Giorgia, additional, Cenni, Anna, additional, Trane, Cinzia, additional, Peruzzi, Antonio, additional, and Aprea, Maria Cristina, additional

Published
2023
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7. Risk of childhood leukaemia and non-Hodgkin's lymphoma after parental occupational exposure to solvents and other agents: the SETIL Study

Author

SETIL Working Group, Miligi, Lucia, Benvenuti, Alessandra, Mattioli, Stefano, Salvan, Alberto, Tozzi, Giulio Andrea, Ranucci, Alessandra, Legittimo, Patrizia, Rondelli, Roberto, Bisanti, Luigi, Zambon, Paola, Cannizzaro, Santina, Kirchmayer, Ursula, Cocco, Pierluigi, Celentano, Egidio, Assennato, Giorgio, Merlo, Domenico Franco, Mosciatti, Paola, Minelli, Liliana, Cuttini, Marina, Torregrossa, Valeria, Lagorio, Susanna, Haupt, Riccardo, Risica, Serena, Polichetti, Alessandro, and Magnani, Corrado

Published
2013
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8. Air pollution and childhood leukaemia: a nationwide case-control study in Italy

Author

Badaloni, C, Ranucci, A, Cesaroni, G, Zanini, G, Vienneau, D, Al-Aidrous, F, De Hoogh, K, Magnani, C, Forastiere, F, Magnani, Corrado, Mattioli, Stefano, Miligi, Lucia, Ranucci, Alessandra, Rondelli, Roberto, Salvan, Alberto, Masera, Giuseppe, Rizzari, Carmelo, Bisanti, Luigi, Zambon, Paola, Greco, Alessandra, Cannizzaro, Santina, Gafà, Lorenzo, Luzzatto, Lia Lidia, Benvenuti, Alessandra, Michelozzi, Paola, Kirchmayer, Ursula, Cocco, Pierluigi, Galassi, Claudia, Celentano, Egidio, Guarino, Erni, Assennato, Giorgio, de Nichilo, Gigliola, Merlo, Domenico Franco, Bocchini, Vittorio, Mosciatti, Paola, Minelli, Liliana, Chiavarini, Manuela, Cuttini, Marina, Casotto, Veronica, Torregrossa, Maria Valeria, Valenti, Rosaria Maria, Forastiere, Francesco, Haupt, Riccardo, Lagorio, Susanna, Risica, Serena, Polichetti, Alessandro, Bochicchio, Francesco, Nuccetelli, Cristina, Biddau, Pierfranco, Aricò, Maurizio, De Salvo, Gian Luca, Locatelli, Franco, Pession, Andrea, Varotto, Stefania, Poggi, Vincenzo, Massaglia, Pia, Monetti, Daniele, Targhetta, Roberto, Bernini, Gabriella, Pannelli, Franco, Sampietro, Giuseppe, Schilirò, Gino, and Pulsoni, Alessandro

Published
2013
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9. Risk of childhood leukaemia and non-Hodgkinʼs lymphoma after parental occupational exposure to solvents and other agents: the SETIL Study

Author

Miligi, Lucia, Benvenuti, Alessandra, Mattioli, Stefano, Salvan, Alberto, Tozzi, Giulio Andrea, Ranucci, Alessandra, Legittimo, Patrizia, Rondelli, Roberto, Bisanti, Luigi, Zambon, Paola, Cannizzaro, Santina, Kirchmayer, Ursula, Cocco, Pierluigi, Celentano, Egidio, Assennato, Giorgio, Merlo, Domenico Franco, Mosciatti, Paola, Minelli, Liliana, Cuttini, Marina, Torregrossa, Valeria, Lagorio, Susanna, Haupt, Riccardo, Risica, Serena, Polichetti, Alessandro, Monetti, Daniele, Veneto, Istituto Oncologico, Gafà, Lorenzo, Luzzatto, Lia Lidia, Michelozzi, Paola, Forastiere, Francesco, Gelli, Luigi, Assennato, Giorgio, Pannelli, Franco, Chiavarini, Manuela, Lippi, Alma, Bernini, Gabriella, Nardi, Margherita, Acquaviva, Antonio, Adesi, Francesco Barone, Cavariani, Fulvio, Belletti, Isabella, Troeschel, Loredana, Calisti, Roberto, Silvestri, Stefano, Sommani, Letizia, Miceli, Giuseppe, Farioli, Andrea, and Magnani, Corrado

Published
2013
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10. Role of asbestos clearance in explaining long-term risk of pleural and peritoneal cancer: a pooled analysis of cohort studies

Author

Barone-Adesi, Francesco, primary, Ferrante, Daniela, additional, Chellini, Elisabetta, additional, Merler, Enzo, additional, Pavone, Venere, additional, Silvestri, Stefano, additional, Miligi, Lucia, additional, Gorini, Giuseppe, additional, Bressan, Vittoria, additional, Girardi, Paolo, additional, Ancona, Laura, additional, Romeo, Elisa, additional, Luberto, Ferdinando, additional, Sala, Orietta, additional, Scarnato, Corrado, additional, Menegozzo, Simona, additional, Oddone, Enrico, additional, Tunesi, Sara, additional, Perticaroli, Patrizia, additional, Pettinari, Aldo, additional, Cuccaro, Francesco, additional, Curti, Stefania, additional, Baldassarre, Antonio, additional, Cena, Tiziana, additional, Angelini, Alessia, additional, Marinaccio, Alessandro, additional, Mirabelli, Dario, additional, Musti, Marina, additional, Pirastu, Roberta, additional, Ranucci, Alessandra, additional, and Magnani, Corrado, additional

Published
2019
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11. Valutazione della variazione temporale del rischio di mesotelioma e di tumore del polmone nelle coorti di esposti ad amianto per lavoro in Italia

Author

Magnani, Corrado, Ancona, Laura, Baldassarre, Antonio, Bressan, Vittoria, Cena, Tiziana, Chellini, Elisabetta, Cuccaro, Francesco, Ferrante, Daniela, Legittimo, Patrizia, Luberto, Ferdinando, Marinaccio, Alessandro, Mattioli, Stefano, Menegozzo, Simona, Merler, Enzo, Miligi, Lucia, Mirabelli, Dario, Musti, Marina, Oddone, Enrico, Pavone, Venere, Perticaroli, Patrizia, Pettinari, Aldo, Pirastu, Roberta, Ranucci, Alessandra, Romeo, Elisa, Sala, Orietta, Scarnato, Corrado, Silvestri, Stefano, Curti, Stefania, Magnani, Corrado, Ancona, Laura, Baldassarre, Antonio, Bressan, Vittoria, Cena, Tiziana, Chellini, Elisabetta, Cuccaro, Francesco, Ferrante, Daniela, Legittimo, Patrizia, Luberto, Ferdinando, Marinaccio, Alessandro, Mattioli, Stefano, Menegozzo, Simona, Merler, Enzo, Miligi, Lucia, Mirabelli, Dario, Musti, Marina, Oddone, Enrico, Pavone, Venere, Perticaroli, Patrizia, Pettinari, Aldo, Pirastu, Roberta, Ranucci, Alessandra, Romeo, Elisa, Sala, Orietta, Scarnato, Corrado, Silvestri, Stefano, [.., Curti, Stefania, and ]

Subjects
Male, Mesothelioma, Lung Neoplasms, Epidemiology, Environmental and Occupational Health, Asbestosi, Public Health, Environmental and Occupational Health, Socio-culturale, Ambientale, Asbesto, Asbestos, Occupational Disease, Lung Neoplasm, Occupational Diseases, Economica, Italy, Occupational Exposure, Asbestosis, Humans, Female, Public Health, Human
Abstract

This study aims at investigating, in asbestos exposed workers, the time trend of their risk of mesothelioma and of other neoplasm after very long latency and after the cessation of asbestos exposure. We pooled a large number of Italian cohorts of asbestos workers and updated mortality follow-up. The pool of data for statistical analyses includes 51,988 workers, of which 6,058 women: 54.2% was alive at follow-up, 42.6% was dead, and 2.8%was lost. Cause of death is known for 94.3%: 2,548 deaths from lung cancer, 748 frompleural cancer, 173 fromperitoneal cancer, and 434 from asbestosis. An exposure index is being developed to compare the different cohorts. Data analysis is in progress. This study will have the size for analysing not only time trends in mesothelioma, but also the occurrence of rarer diseases and cancer specific mortality in women.

Published
2016

12. Italian pool of asbestos workers cohorts: asbestos related mortality by industrial sector and cumulative exposure.

Author

Magnani, Corrado, Silvestri, Stefano, Angelini, Alessia, Ranucci, Alessandra, Azzolina, Danila, Cena, Tiziana, Chellini, Elisabetta, Merler, Enzo, Pavone, Venere, Miligi, Lucia, Gorini, Giuseppe, Bressan, Vittoria, Girardi, Paolo, Bauleo, Lisa, Romeo, Elisa, Luberto, Ferdinando, Sala, Orietta, Scarnato, Corrado, Menegozzo, Simona, and Oddone, Enrico

Published
2020
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13. O32-3 A pooled cohort study on cancer risk among former asbestos-exposed workers: role of asbestos clearance in explaining long-term mortality trend for pleural cancer

Author

Magnani, Corrado, primary, Barone-Adesi, Francesco, additional, Ferrante, Daniela, additional, Ancona, Laura, additional, Baldassarre, Antonio, additional, Bressan, Vittoria, additional, Cena, Tizian, additional, Chellini, Elisabetta, additional, Cuccaro, Francesco, additional, Legittimo, Patrizia, additional, Luberto, Ferdinando, additional, Marinaccio, Alessandro, additional, Mattioli, Stefano, additional, Menegozzo, Simona, additional, Merler, Enzo, additional, Miligi, Lucia, additional, Mirabelli, Dario, additional, Musti, Marina, additional, Oddone, Enrico, additional, Pavone, Venere, additional, Perticaroli, Patrizia, additional, Pettinari, Aldo, additional, Pirastu, Roberta, additional, Ranucci, Alessandra, additional, Romeo, Elisa, additional, Sala, Orietta, additional, Scarnato, Corrado, additional, Silvestri, Stefano, additional, and W, G, additional

Published
2016
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14. A pooled cohort analysis on cancer risk among former asbestos-exposed workers: role of asbestos clearance in explaining long-term mortality trend for pleural cancer.

Author

Magnani, Corrado, primary, Barone-Adesi*, Francesco, additional, Ferrante, Daniela, additional, Ancona, Laura, additional, Baldassarre, Antonio, additional, Bressan, Vittoria, additional, Cena, Tiziana, additional, Chellini, Elisabetta, additional, Cuccaro, Francesco, additional, Legittimo, Patrizia, additional, Luberto, Ferdinando, additional, Marinaccio, Alessandro, additional, Mattioli, Stefano, additional, Menegozzo, Simona, additional, Merler, Enzo, additional, Miligi, Lucia, additional, Mirabelli, Dario, additional, Musti, Marina, additional, Oddone, Enrico, additional, Pavone, Venere, additional, Perticaroli, Patrizia, additional, Pettinari, Aldo, additional, Pirastu, Roberta, additional, Ranucci, Alessandra, additional, Romeo, Elisa, additional, Sala, Orietta, additional, Scarnato, Corrado, additional, Silvestri, Stefano, additional, and Group, Working, additional

Published
2016
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16. SETIL: Italian multicentric epidemiological case–control study on risk factors for childhood leukaemia, non hodgkin lymphoma and neuroblastoma: study population and prevalence of risk factors in Italy

Author

Magnani, Corrado, primary, Mattioli, Stefano, additional, Miligi, Lucia, additional, Ranucci, Alessandra, additional, Rondelli, Roberto, additional, Salvan, Alberto, additional, Bisanti, Luigi, additional, Masera, Giuseppe, additional, Rizzari, Carmelo, additional, Zambon, Paola, additional, Cannizzaro, Santina, additional, Gafà, Lorenzo, additional, Luzzatto, Lia Lidia, additional, Benvenuti, Alessandra, additional, Michelozzi, Paola, additional, Kirchmayer, Ursula, additional, Cocco, Pierluigi, additional, Biddau, Pierfranco, additional, Galassi, Claudia, additional, Celentano, Egidio, additional, Guarino, Erni, additional, Assennato, Giorgio, additional, de Nichilo, Gigliola, additional, Merlo, Domenico Franco, additional, Bocchini, Vittorio, additional, Pannelli, Franco, additional, Mosciatti, Paola, additional, Minelli, Liliana, additional, Chiavarini, Manuela, additional, Cuttini, Marina, additional, Casotto, Veronica, additional, Torregrossa, Maria Valeria, additional, Valenti, Rosalia Maria, additional, Forastiere, Francesco, additional, Haupt, Riccardo, additional, Lagorio, Susanna, additional, Risica, Serena, additional, and Polichetti, Alessandro, additional

Published
2014
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18. Exposure to benzene and childhood leukaemia: a pilot case-control study

Author

Lagorio, Susanna, primary, Ferrante, Daniela, additional, Ranucci, Alessandra, additional, Negri, Sara, additional, Sacco, Paolo, additional, Rondelli, Roberto, additional, Cannizzaro, Santina, additional, Torregrossa, Maria Valeria, additional, Cocco, Pierluigi, additional, Forastiere, Francesco, additional, Miligi, Lucia, additional, Bisanti, Luigi, additional, and Magnani, Corrado, additional

Published
2013
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20. Tobacco Smoke and Risk of Childhood Acute Non-Lymphocytic Leukemia: Findings from the SETIL Study.

Author

Mattioli, Stefano, Farioli, Andrea, Legittimo, Patrizia, Miligi, Lucia, Benvenuti, Alessandra, Ranucci, Alessandra, Salvan, Alberto, Rondelli, Roberto, Magnani, Corrado, and null, null

Subjects
LYMPHOCYTIC leukemia, TOBACCO smoke pollution, JUVENILE diseases, CANCER risk factors, CONFIDENCE intervals, MATERNAL exposure, DISEASE risk factors
Abstract

Background: Parental smoking and exposure of the mother or the child to environmental tobacco smoke (ETS) as risk factors for Acute non-Lymphocytic Leukemia (AnLL) were investigated. Methods: Incident cases of childhood AnLL were enrolled in 14 Italian Regions during 1998–2001. We estimated odds ratios (OR) and 95% confidence intervals (95%CI) conducting logistic regression models including 82 cases of AnLL and 1,044 controls. Inverse probability weighting was applied adjusting for: age; sex; provenience; birth order; birth weight; breastfeeding; parental educational level age, birth year, and occupational exposure to benzene. Results: Paternal smoke in the conception period was associated with AnLL (OR for ≥11 cigarettes/day  = 1.79, 95% CI 1.01–3.15; P trend 0.05). An apparent effect modification by maternal age was identified: only children of mothers aged below 30 presented increased risks. We found weak statistical evidence of an association of AnLL with maternal exposure to ETS (OR for exposure>3 hours/day  = 1.85, 95%CI 0.97–3.52; P trend 0.07). No association was observed between AnLL and either maternal smoking during pregnancy or child exposure to ETS. Conclusions: This study is consistent with the hypothesis that paternal smoke is associated with AnLL. We observed statistical evidence of an association between maternal exposure to ETS and AnLL, but believe bias might have inflated our estimates. [ABSTRACT FROM AUTHOR]

Published
2014
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22. Elicitation of phenylalanine ammonia-lyase in Daucus carotaby oligogalacturonides released from sodium polypectate by homogeneous polygalacturonase

Author

De Lorenzo, Giulia, Ranucci, Alessandra, Bellincampi, Daniela, Salvi, Giovanni, and Cervone, Felice

Abstract

α-d-Galacturonide oligomers were prepared by partial hydrolysis of sodium polypectate with homogeneous polygalacturonase from Aspergillus niger. The oligomers were able to induce a strong increase in the activity of phenylalanine ammonia-lyase in Daucus carotacell suspension cultures, probably as a result of increased de novo synthesis of the enzyme. The induction of phenylalanine ammonia-lyase (PAL) was transient and occurred rapidly after treatment with oligo-galacturonides. The concentration of oligogalacturonides capable of inducing enzyme activity was 6 × 10−6M and lower. Oligomers with degrees of polymerization from 2 to 5 were purified to homogeneity and assayed for PAL-inducing activity. The pentamer possessed the highest activity and the trimer the lowest. Mono- and digalacturonate did not exhibit any activity.

Published
1987
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23. Tac-Positive, HTLV-Negative, T Helper Phenotype Chronic Lymphocytic Leukemia Cells

Author

Pandolfi, Franco, Rossi, Giulio De, Ranucci, Alessandra, Bonomo, Giuseppe, Pasqualetti, Daniela, Napolitano, Monica, and Manzari, I Vittorio

Abstract

In this report we describe an Italian patient with chronic T cell leukemia whose proliferating cells were mature T lymphocytes with a helper phenotype (T helper phenotype chronic lymphocytic leukemia, or Thp-CLL). Unlike other reported cases of Thp-CLL, fresh leukemic cells from this patient were positive with the anti-Tac monoclonal antibody, which recognizes the receptor for interleukin-2 (lL-2). Thus, the phenotype of these cells was similar to that expressed by Japanese patients with adult T cell leukemia (ATL) (OKT3 , OKT4+, OKT8 , Tac+). However, the Italian patient had Thp-CLL, not ATL, since his cells, unlike ATL cells, lacked human T cell leukemia virus (HTLV-l)-related DNA sequences. The Tac receptor, which appears to be modulated in vitro by the anti-Tac antibody, was biologically inactive, since the patient's cells did not respond in vitro to IL-2. In addition, they also failed to demonstrate in vitro functional activities. The clinical course was aggressive, as usual, for both Thp-CLL and ATL. Taking advantage of the description of this case, some similarities and differences between Thp-CLL and ATL are discussed, focusing on the importance of screening of HTLV-I in the differential diagnosis. © 1985 by Grune & Stratton, Inc.

Published
1985
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24. Immunologic Evaluation of T Chronic Lymphocyte Leukemia Cells: Correlations Among Phenotype, Functional Activities, and Morphology

Author

Pandolfi, Franco, Rossi, Giulio De, Semenzato, Giampietro, Quinti, Isabella, Ranucci, Alessandra, Sanctis, Giuliana De, Lopez, Manuela, Gasparotto, Giuseppe, and Aiuti, Fernando

Abstract

Chronic lymphocytic leukemia of T-cell origin (T-CLL), a rare variant of CLL, appears to be a clonal proliferation of mature T cells of one of several subsets. In the cells of 7 T-CLL patients, surface markers (including those reacting with a panel of monoclonal antibodies), functional activities, and electron microscopic morphology were evaluated. The phenotypic patterns of circulating T-CLL cells correspond to those of normal mature T-cell subsets. The cells of three patients demonstrated at least one marker reported to be expressed by suppressor/cytotoxic T cells; those of three patients expressed markers apparently linked with T-helper activity. Cells from one patient appeared to be a heterogeneous proliferation of more than one T-cell subset. These T-CLL cells may also retain some of the functional activity of the normal T subpopulations. Our data indicate that a combination of several tests should be used to characterize the proliferating cells in T-CLL.

Published
1982
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25. Time trend in mesothelioma and lung cancer risk in asbestos workers in Italy

Author

Magnani, Corrado, Ancona, Laura, Baldassarre, Antonio, Bressan, Vittoria, Cena, Tiziana, Chellini, Elisabetta, Cuccaro, Francesco, Ferrante, Daniela, Legittimo, Patrizia, Ferdinando Luberto, Marinaccio, Alessandro, Mattioli, Stefano, Menegozzo, Simona, Merler, Enzo, Miligi, Lucia, Mirabelli, Dario, Musti, Marina, Oddone, Enrico, Pavone, Venere, Perticaroli, Patrizia, Pettinari, Aldo, Pirastu, Roberta, Ranucci, Alessandra, Romeo, Elisa, Sala, Orietta, Scarnato, Corrado, and Silvestri, Stefano

28. Childhood Leukemia and 50 Hz Magnetic Fields: Findings from the Italian SETIL Case-Control Study

Author

Daniele Andreuccetti, Ursula Kirchmayer, Stefano Mattioli, Andrea Farioli, Liliana Minelli, Santi Tofani, Alessandro Polichetti, Paola Michelozzi, Gian Luca De Salvo, Susanna Lagorio, Manuela Chiavarini, Salvan, Alberto, Ranucci, Alessandra, Lagorio, Susanna, Magnani, Corrado, [ .., Mattioli, Stefano, ], and Panico, Salvatore

Subjects
Male, Pediatrics, Health, Toxicology and Mutagenesis, lcsh:Medicine, Economica, Extremely low frequency (ELF) magnetic field, Risk Factors, Magnetic Field, Epidemiology, Child, education.field_of_study, Leukemia, extremely low frequency (ELF) magnetic fields, Regression, Health, Child, Preschool, Female, epidemiology, Public Health, Case-Control Studie, Human, medicine.medical_specialty, Childhood leukemia, case-control study, Population, Socio-culturale, acute lymphoblastic leukemia, Article, medicine, Humans, Toxicology and Mutagenesis, Preschool, education, childhood, business.industry, Risk Factor, lcsh:R, Environmental and Occupational Health, Public Health, Environmental and Occupational Health, Case-control study, Ambientale, Infant, medicine.disease, Magnetic Fields, Case-Control Studies, Attributable risk, Housing, Geometric mean, business
Abstract

We report on an Italian case-control study on childhood leukemia and exposure to extremely low frequency magnetic fields (ELF-MF). Eligible for inclusion were 745 leukemia cases, aged 0–10 years at diagnosis in 1998–2001, and 1475 sex- and age-matched population controls. Parents of 683 cases and 1044 controls (92% vs. 71%) were interviewed. ELF-MF measurements (24–48 h), in the child’s bedroom of the dwelling inhabited one year before diagnosis, were available for 412 cases and 587 controls included in the main conditional regression analyses. The magnetic field induction was 0.04 μT on average (geometric mean), with 0.6% of cases and 1.6% of controls exposed to &gt, 0.3 μT. The impact of changes in the statistical model, exposure metric, and data-set restriction criteria was explored via sensitivity analyses. No exposure-disease association was observed in analyses based on continuous exposure, while analyses based on categorical variables were characterized by incoherent exposure-outcome relationships. In conclusion, our results may be affected by several sources of bias and they are noninformative at exposure levels &gt, 0.3 μT. Nonetheless, the study may contribute to future meta- or pooled analyses. Furthermore, exposure levels among population controls are useful to estimate attributable risk.

Published
2015
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29. Italian pool of asbestos workers cohorts: Mortality trends of asbestos-related neoplasms after long time since first exposure

Author

Simona Menegozzo, Dario Mirabelli, Francesco Cuccaro, Orietta Sala, Francesco Barone-Adesi, Daniela Ferrante, Vittoria Bressan, Lucia Miligi, Alessandro Marinaccio, Aldo Pettinari, Corrado Magnani, Paolo Girardi, Enzo Merler, Elisabetta Chellini, Venere Pavone, Alessandra Ranucci, Enrico Oddone, Patrizia Legittimo, Stefano Mattioli, Corrado Scarnato, Stefano Silvestri, Sara Tunesi, Laura Ancona, Patrizia Perticaroli, Roberta Pirastu, Marina Musti, Antonio Baldassarre, Tiziana Cena, Giuseppe Gorini, Elisa Romeo, Ferdinando Luberto, Ferrante, Daniela, Chellini, Elisabetta, Merler, Enzo, Pavone, Venere, Silvestri, Stefano, Miligi, Lucia, Gorini, Giuseppe, Bressan, Vittoria, Girardi, Paolo, Ancona, Laura, Romeo, Elisa, Luberto, Ferdinando, Sala, Orietta, Scarnato, Corrado, Menegozzo, Simona, Oddone, Enrico, Tunesi, Sara, Perticaroli, Patrizia, Pettinari, Aldo, Cuccaro, Francesco, Mattioli, Stefano, Baldassarre, Antonio, Barone-Adesi, Francesco, Cena, Tiziana, Legittimo, Patrizia, Marinaccio, Alessandro, Mirabelli, Dario, Musti, Marina, Pirastu, Roberta, Ranucci, Alessandra, Magnani, Corrado, [.., Curti, Stefania, and ]

Subjects
Male, Mesothelioma, Occupational cancer, Lung Neoplasms, Asbestosis, medicine.disease_cause, Cohort Studies, Economica, 0302 clinical medicine, Cause of Death, PLEURAL MESOTHELIOMA, TEXTILE WORKERS, Pleural Neoplasm, Lung, Peritoneal Neoplasms, Cause of death, LARYNGEAL-CANCER-MORTALITY, RISK, Ovarian Neoplasms, Asbestosi, Middle Aged, peritoneum, 030210 environmental & occupational health, Asbestos cement, Occupational Diseases, pleura, Italy, 030220 oncology & carcinogenesis, malignant mesothelioma, Female, Public Health, Peritoneal Neoplasm, FIBERS, Carcinogen, Cohort study, Human, Adult, medicine.medical_specialty, Pleural Neoplasms, MODELS, Socio-culturale, Asbesto, Asbestos, Settore MED/01 - Statistica Medica, CEMENT WORKERS, 03 medical and health sciences, LUNG-CANCER, asbestos, occupational cancer, ovary, Internal medicine, Occupational Exposure, medicine, Humans, METAANALYSIS, Aged, LARYNGEAL-CANCER-MORTALITY, PLEURAL MESOTHELIOMA, TEXTILE WORKERS, LUNG-CANCER, FOLLOW-UP, CEMENT WORKERS,MODELS, RISK, METAANALYSIS, FIBERS, business.industry, Construction Materials, Ovarian Neoplasm, Environmental and Occupational Health, Mesothelioma, Malignant, Ovary, Public Health, Environmental and Occupational Health, Ambientale, medicine.disease, Surgery, Construction Material, Lung Neoplasm, Occupational Disease, Carcinogens, Cohort Studie, FOLLOW-UP, Ovarian cancer, business
Abstract

Objective Asbestos is a known human carcinogen, with evidence for malignant mesothelioma (MM), cancers of lung, ovary, larynx and possibly other organs. MM rates are predicted to increase with a power of time since first exposure (TSFE), but the possible long-term attenuation of the trend is debated. The asbestos ban enforced in Italy in 1992 gives an opportunity to measure long-term cancer risk in formerly exposed workers. Methods Pool of 43 previously studied Italian asbestos cohorts (asbestos cement, rolling stock, shipbuilding), with mortality follow-up updated to 2010. SMRs were computed for the 1970–2010 period, for the major causes, with consideration of duration and TSFE, using reference rates by age, sex, region and calendar period. Results The study included 51 801 subjects (5741 women): 55.9% alive, 42.6% died (cause known for 95%) and 1.5% lost to follow-up. Mortality was significantly increased for all deaths (SMR: men: 1.05, 95% CI 1.03 to 1.06; women: 1.17, 95% CI to 1.12 to 1.22), all malignancies combined (SMR: men: 1.17, 95% CI to 1.14 to 1.20; women: 1.33, 95% CI 1.24 to 1.43), pleural and peritoneal malignancies (SMR: men: 13.28 and 4.77, 95% CI 12.24 to 14.37 and 4.00 to 5.64; women: 28.44 and 6.75, 95% CI 23.83 to 33.69 and 4.70 to 9.39), lung (SMR: men: 1.26, 95% CI 1.21 to 1.31; women: 1.43, 95% CI 1.13 to 1.78) and ovarian cancer (SMR=1.38, 95% CI 1.00 to 1.87) and asbestosis (SMR: men: 300.7, 95% CI 270.7 to 333.2; women: 389.6, 95% CI 290.1 to 512.3). Pleural cancer rate increased during the first 40 years of TSFE and reached a plateau after. Discussion The study confirmed the increased risk for cancer of the lung, ovary, pleura and peritoneum but not of the larynx and the digestive tract. Pleural cancer mortality reached a plateau at long TSFE, coherently with recent reports.

Published
2017

30. Road Traffic Pollution and Childhood Leukemia: A Nationwide Case-control Study in Italy

Author

Corrado Magnani, Alessandra Ranucci, Chiara Badaloni, Giulia Cesaroni, Daniela Ferrante, Lucia Miligi, Stefano Mattioli, Roberto Rondelli, Luigi Bisanti, Paola Zambon, Santina Cannizzaro, Paola Michelozzi, Pierluigi Cocco, Egidio Celentano, Giorgio Assennato, Domenico Franco Merlo, Paola Mosciatti, Liliana Minelli, Marina Cuttini, Maria Valeria Torregrossa, Susanna Lagorio, Riccardo Haupt, Francesco Forastiere, Andrea Farioli, Alberto Salvan, Giuseppe Masera, Carmelo Rizzari, Alessandra Greco Veneto, Lorenzo Gafà, Lia Lidia Luzzatto, Alessandra Benvenuti, Ursula Kirchmayer, Claudia Galassi, Erni Guarino, Gigliola de Nichilo, Vittorio Bocchini, Manuela Chiavarini, Veronica Casotto, Rosaria Maria Valenti, Serena Risica, Alessandro Polichetti, Francesco Bochicchio, Cristina Nuccetelli, Pierfranco Biddau, Maurizio Aricò, Gian Luca DeSalvo, Franco Locatelli, Andrea Pession, Stefania Varotto, Vincenzo Poggi, Pia Massaglia, Daniele Monetti, Roberto Targhetta, Gabriella Bernini, Franco Pannelli, Giuseppe Sampietro, Gino Schilirò, Alessandro Pulsoni, Stefano Parodi, Magnani, Corrado, Ranucci, Alessandra, Badaloni, Chiara, Cesaroni, Giulia, Ferrante, Daniela, Miligi, Lucia, Mattioli, Stefano, Rondelli, Roberto, Bisanti, Luigi, Zambon, Paola, Cannizzaro, Santina, Michelozzi, Paola, Cocco, Pierluigi, Celentano, Egidio, Assennato, Giorgio, Merlo, Domenico Franco, Mosciatti, Paola, Minelli, Liliana, Cuttini, Marina, Torregrossa, Maria Valeria, Lagorio, Susanna, Haupt, Riccardo, Forastiere, Francesco, Magnani C, Ranucci A, Badaloni C, Cesaroni G, Ferrante D, Miligi L, Mattioli S, Rondelli R, Bisanti L, Zambon P, Cannizzaro S, Michelozzi P, Cocco P, Celentano E, Assennato G, Merlo DF, Mosciatti P, Minelli L, Cuttini M, Torregrossa MV, Lagorio S, Haupt R, Forastiere F, SETIL Working Group., Magnani, C, Ranucci, A, Badaloni, C, Cesaroni, G, Ferrante, D, Miligi, L, Mattioli, S, Rondelli, R, Bisanti, L, Zambon, P, Cannizzaro, S, Michelozzi, P, Cocco, P, Celentano, E, Assennato, G, Merlo, D, Mosciatti, P, Minelli, L, Cuttini, M, Torregrossa, M, Lagorio, S, Haupt, R, Forastiere, F, Farioli, A, Salvan, A, Masera, G, Rizzari, C, Greco Veneto, A, Gafa, L, Luzzatto, L, Benvenuti, A, Kirchmayer, U, Galassi, C, Guarino, E, de Nichilo, G, Bocchini, V, Chiavarini, M, Casotto, V, Valenti, R, Risica, S, Polichetti, A, Bochicchio, F, Nuccetelli, C, Biddau, P, Arico, M, Desalvo, G, Locatelli, F, Pession, A, Varotto, S, Poggi, V, Massaglia, P, Monetti, D, Targhetta, R, Bernini, G, Pannelli, F, Sampietro, G, Schiliro, G, Pulsoni, A, and Parodi, S

Subjects
Myeloid, Male, Future studies, 010501 environmental sciences, Settore MED/42 - Igiene Generale E Applicata, 01 natural sciences, 0302 clinical medicine, Economica, hemic and lymphatic diseases, Medicine, 030212 general & internal medicine, Child, Road traffic, acute non lymphoblastic leukemia, childhood, environment, leukemia, road traffic, air pollution, case-control studies, child, child, preschool, female, humans, infant, Italy, leukemia, myeloid, acute, male, precursor cell lymphoblastic leukemia-lymphoma, risk, motor vehicles, medicine (all), Leukemia, Traffic pollution, Medicine (all), General Medicine, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Motor Vehicles, Leukemia, Myeloid, Acute, Acute non Lymphoblastic Leukemia, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, Road Traffic, Child, Preschool, Female, Medical emergency, Case-Control Studie, Human, Risk, Childhood leukemia, Socio-culturale, Acute, Environment, Precursor Cell Lymphoblastic Leukemia Lymphoma, 03 medical and health sciences, Environmental health, Air Pollution, Humans, Preschool, 0105 earth and related environmental sciences, business.industry, Case-control study, Type specific, Ambientale, Infant, medicine.disease, Childhood, Case-Control Studies, Motor Vehicle, business
Abstract

Background The association of childhood leukemia with traffic pollution was considered in a number of studies from 1989 onwards, with results not entirely consistent and little information regarding subtypes. Aim of the study We used the data of the Italian SETIL case-control on childhood leukemia to explore the risk by leukemia subtypes associated to exposure to vehicular traffic. Methods We included in the analyses 648 cases of childhood leukemia (565 Acute lymphoblastic–ALL and 80 Acute non lymphoblastic-AnLL) and 980 controls. Information on traffic exposure was collected from questionnaire interviews and from the geocoding of house addresses, for all periods of life of the children. Results We observed an increase in risk for AnLL, and at a lower extent for ALL, with indicators of exposure to traffic pollutants. In particular, the risk was associated to the report of closeness of the house to traffic lights and to the passage of trucks (OR: 1.76; 95% CI 1.03–3.01 for ALL and 6.35; 95% CI 2.59–15.6 for AnLL). The association was shown also in the analyses limited to AML and in the stratified analyses and in respect to the house in different period of life. Conclusions Results from the SETIL study provide some support to the association of traffic related exposure and risk for AnLL, but at a lesser extent for ALL. Our conclusion highlights the need for leukemia type specific analyses in future studies. Results support the need of controlling exposure from traffic pollution, even if knowledge is not complete.

Published
2016

31. SETIL: Italian multicentric epidemiological case–control study on risk factors for childhood leukaemia, non hodgkin lymphoma and neuroblastoma: study population and prevalence of risk factors in Italy

Author

Lucia Miligi, Corrado Magnani, Susanna Lagorio, Pierluigi Cocco, Claudia Galassi, Roberto Rondelli, Veronica Casotto, L. Gafa, Ursula Kirchmayer, Rosalia Maria Valenti, Serena Risica, Maria Valeria Torregrossa, Marina Cuttini, Paola Mosciatti, Luigi Bisanti, Erni Guarino, Egidio Celentano, Francesco Forastiere, Giuseppe Masera, Alessandro Polichetti, Alberto Salvan, Paola Zambon, Alessandra Benvenuti, Domenico Franco Merlo, Manuela Chiavarini, Lia Lidia Luzzatto, Vittorio Bocchini, Pierfranco Biddau, Stefano Mattioli, Alessandra Ranucci, Liliana Minelli, F. Pannelli, Santina Cannizzaro, Gigliola de Nichilo, Carmelo Rizzari, Giorgio Assennato, Paola Michelozzi, Riccardo Haupt, Magnani, C., Mattioli, S., Miligi, L., Ranucci, A., Rondelli, R., Salvan, A., Bisanti, L., Masera, G., Rizzari, C., Zambon, P., Cannizzaro, S., Gafà, L., Luzzatto, L., Benvenuti, A., Michelozzi, P., Kirchmayer, U., Cocco, P., Biddau, P., Galassi, C., Celentano, E., Guarino, E., Assennato, G., Nichilo, G., Merlo, D., Bocchini, V., Pannelli, F., Mosciatti, P., Minelli, L., Chiavarini, M., Cuttini, M., Casotto, V., Torregrossa, M., Valenti, R., Forastiere, F., Haupt, R., Lagorio, S., Risica, S., Polichetti, A., Magnani, Corrado, Mattioli, Stefano, Miligi, Lucia, Ranucci, Alessandra, Rondelli, Roberto, Salvan, Alberto, Bisanti, Luigi, Masera, Giuseppe, Rizzari, Carmelo, Zambon, Paola, Cannizzaro, Santina, Gafà, Lorenzo, Luzzatto, Lia Lidia, Benvenuti, Alessandra, Michelozzi, Paola, Kirchmayer, Ursula, Cocco, Pierluigi, Biddau, Pierfranco, Galassi, Claudia, Celentano, Egidio, Guarino, Erni, Assennato, Giorgio, de Nichilo, Gigliola, Merlo, Domenico Franco, Bocchini, Vittorio, Pannelli, Franco, Mosciatti, Paola, Minelli, Liliana, Chiavarini, Manuela, Cuttini, Marina, Casotto, Veronica, Torregrossa, Maria Valeria, Valenti, Rosalia Maria, Forastiere, Francesco, Haupt, Riccardo, Lagorio, Susanna, Risica, Serena, and Polichetti, Alessandro

Subjects
Male, Pediatrics, Passive smoking, Lymphoma, Epidemiology, Non hogdkin lymphoma, medicine.disease_cause, Settore MED/42 - Igiene Generale E Applicata, Neuroblastoma, Economica, hemic and lymphatic diseases, Prevalence, risk factors, Leukaemia, Child, education.field_of_study, Incidence (epidemiology), Incidence, Lymphoma, Non-Hodgkin, non hodgkin lymphoma and neuroblastoma, Environmental exposure, Italy, Child, Preschool, Population study, Female, Human, medicine.medical_specialty, Population, Non-Hodgkin, Socio-culturale, study population, Risk Assessment, childhood leukaemia, medicine, Humans, education, Preschool, Pregnancy, business.industry, Research, Case-control study, Infant, Newborn, Ambientale, Infant, Environmental Exposure, medicine.disease, Newborn, business
Abstract

Background Aetiology of childhood leukaemia and childhood neoplasm is poorly understood. Information on the prevalence of risk factors in the childhood population is limited. SETIL is a population based case–control study on childhood leukaemia, conducted with two companion studies on non-Hodgkin Lymphoma (NHL) and neuroblastoma. The study relies on questionnaire interviews and 50 Hz magnetic field (ELF-MF) indoor measurements. This paper discusses the SETIL study design and includes descriptive information. Methods The study was carried out in 14 Italian regions (78.3% of Italian population aged 0–10). It included leukaemia, NHL and neuroblastoma cases incident in 0–10 year olds in 1998–2001, registered by the Italian Association of Paediatric Haematology and Oncology (AIEOP) (accrual over 95% of estimated incidence). Two controls for each leukaemia case were randomly sampled from the Local Health Authorities rolls, matched by gender, birthdate and residence. The same controls were used in NHL and neuroblastoma studies. Parents were interviewed at home on: physical agents (ELF-MF and ionizing radiation), chemicals (smoking, solvents, traffic, insecticides), occupation, medical and personal history of children and parents, infectious diseases, immunizations and associated factors. Occupational exposure was collected using job specific modules. ELF-MF was measured in the main rooms (spot measurement) and close to child’s bed (48 hours measurement). Results The study included: 683 leukaemia cases (87% ALL, 13% AnLL), 97 NHL, 155 neuroblastomas, and 1044 controls. ELF-MF long term measurements were obtained for 61.1% of controls and 81.6% of leukaemia cases; 8.8% of controls were exposed at over 0.1 microTesla (μT), 3.5% and 2.1% at respectively over 0.2 and 0.3 μT. 25% of controls’ fathers had smoked over 10 cigarettes/day during the year of conception, varying according to education and region. Maternal smoking was less common (71.4% did not smoke in pregnancy). Maternal passive smoking during pregnancy was reported by 31.2% of controls; the child’s passive smoking for 28.6%. Occupational exposure to solvents was estimated in 18.3% of controls’ fathers and 7.7% of mothers. Contact with public was more frequent among mothers (36.1%) than fathers (23.4%). Conclusions SETIL represents a data source on exposure of Italian children to a broad array of potential carcinogenic factors. Electronic supplementary material The online version of this article (doi:10.1186/s13052-014-0103-5) contains supplementary material, which is available to authorized users.

Published
2014

32. Reference rates for cohort studies in Italy: an essential tool in occupational and residential cohort studies.

Author

Pirastu R, Ranucci A, Consonni D, De Santis M, Bruno C, Conti S, Fazzo L, Iavarone I, Pasetto R, Zona A, Magnani C, and Comba P

Subjects
Cohort Studies, Humans, Italy epidemiology, Neoplasms mortality, Residence Characteristics, Occupational Diseases mortality
Abstract

The cohort study aims to test the hypothesis of an association between specific exposure/s and adverse health outcomes. The cohorts include the subjects who experience the exposure/s and are followed up over time to ascertain the health outcomes. This contribution presents the database for the analysis of mortality studies which is made available for public institutions carrying out cohort studies in Italy. The rates were computed from official mortality data from ISTAT. The database contains 141 causes or groups of causes for the years 1970-2012 ensuring correspondence with subsequent editions of ICD (International Classification of Diseases) VIII, IX and X.

Published
2016

33. [Time trend in mesothelioma and lung cancer risk in asbestos workers in Italy].

Author

Magnani C, Ancona L, Baldassarre A, Bressan V, Cena T, Chellini E, Cuccaro F, Ferrante D, Legittimo P, Luberto F, Marinaccio A, Mattioli S, Menegozzo S, Merler E, Miligi L, Mirabelli D, Musti M, Oddone E, Pavone V, Perticaroli P, Pettinari A, Pirastu R, Ranucci A, Romeo E, Sala O, Scarnato C, and Silvestri S

Subjects
Asbestos, Asbestosis, Female, Humans, Italy epidemiology, Male, Occupational Diseases, Lung Neoplasms epidemiology, Mesothelioma epidemiology, Occupational Exposure
Abstract

This study aims at investigating, in asbestos exposed workers, the time trend of their risk of mesothelioma and of other neoplasm after very long latency and after the cessation of asbestos exposure. We pooled a large number of Italian cohorts of asbestos workers and updated mortality follow-up. The pool of data for statistical analyses includes 51,988 workers, of which 6,058 women: 54.2% was alive at follow-up, 42.6% was dead, and 2.8%was lost. Cause of death is known for 94.3%: 2,548 deaths from lung cancer, 748 frompleural cancer, 173 fromperitoneal cancer, and 434 from asbestosis. An exposure index is being developed to compare the different cohorts. Data analysis is in progress. This study will have the size for analysing not only time trends in mesothelioma, but also the occurrence of rarer diseases and cancer specific mortality in women.

Published
2016
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