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6. Phospholipid Fatty Acid Profiles of Plasma and Erythrocyte Membranes in Dogs Fed with Commercial Granulated Food

Author

Popović Tamara, Debeljak Martačić Jasmina, Pokimica Biljana, Ravić Branko, Ranković Slavica, Glibetić Maria, and Stepanović Predrag

Subjects
commercial foods, dogs, fatty acids profiles, n-3 fatty acids, phospholipids, Veterinary medicine, SF600-1100
Abstract

Intake of long-chain n-3 polyunsaturated fatty acids (PUFA) benefits human and animal health. Our study aimed to analyze the long-chain n-3 PUFA content of two types of food and their effect on plasma and erythrocyte phospholipids of Belgian Shepherd dogs. A total of 10 dogs were fed commercial granulated food (Food 1), and another 10 were provided commercial Premium granulated food of high quality (Food 2). All the analyses were performed using gas-liquid chromatography. Our results showed that Food 1 contained more n-3 PUFA than Food 2, which was reflected in higher n-3 PUFA in plasma and erythrocyte phospholipids. Because long-chain n-3 PUFA in phospholipids are precursors for antioxidative molecules, further studies should investigate the effects of the analyzed commercial granulated food rich in n-3 on oxidative stress parameters in dogs.

Published
2023
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10. Current Insights into the Effects of Dietary α-Linolenic Acid Focusing on Alterations of Polyunsaturated Fatty Acid Profiles in Metabolic Syndrome.

Author

Takić, Marija, Ranković, Slavica, Girek, Zdenka, Pavlović, Suzana, Jovanović, Petar, Jovanović, Vesna, and Šarac, Ivana

Subjects
*UNSATURATED fatty acids, *EICOSAPENTAENOIC acid, *METABOLIC syndrome, *DOCOSAHEXAENOIC acid, *INSULIN sensitivity, *OXYLIPINS, *BLOOD pressure
Abstract

The plant-derived α-linolenic acid (ALA) is an essential n-3 acid highly susceptible to oxidation, present in oils of flaxseeds, walnuts, canola, perilla, soy, and chia. After ingestion, it can be incorporated in to body lipid pools (particularly triglycerides and phospholipid membranes), and then endogenously metabolized through desaturation, elongation, and peroxisome oxidation to eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), with a very limited efficiency (particularly for DHA), beta-oxidized as an energy source, or directly metabolized to C18-oxilipins. At this moment, data in the literature about the effects of ALA supplementation on metabolic syndrome (MetS) in humans are inconsistent, indicating no effects or some positive effects on all MetS components (abdominal obesity, dyslipidemia, impaired insulin sensitivity and glucoregulation, blood pressure, and liver steatosis). The major effects of ALA on MetS seem to be through its conversion to more potent EPA and DHA, the impact on the n-3/n-6 ratio, and the consecutive effects on the formation of oxylipins and endocannabinoids, inflammation, insulin sensitivity, and insulin secretion, as well as adipocyte and hepatocytes function. It is important to distinguish the direct effects of ALA from the effects of EPA and DHA metabolites. This review summarizes the most recent findings on this topic and discusses the possible mechanisms. [ABSTRACT FROM AUTHOR]

Published
2024
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11. The effects of fish-based and milk-based diets on liver tissue antioxidant enzymes and lipid peroxidation in female Wistar rats: A pilot study

Author

Vidović Nevena, Ranković Slavica, Oreščanin-Dušić Zorana, Debeljak-Martačić Jasmina, Popović Tamara, Tomić Mirko, and Glibetić Marija

Subjects
antioxidants, catalase, enzymes, fatty acids, omega-3, fishes, food, lipid peroxidation, milk, rats, superoxide dismutase, Medicine (General), R5-920
Abstract

Background/Aim. Recently, there has been an increased interest in novel dietary antioxidants, including omega-3 fatty acids and bioactive proteins present in milk. The aim of this study was to examine potential antioxidant effects of four-weeks long fish-based and milk-based diets in female Wistar rats. Methods. Four-months old rats were divided into three groups receiving either: control diet, diet enriched with fish meal, or diet enriched with milk. The activities of antioxidant enzymes: glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT), and concentration of thiobarbituric acid reactive substances (TBARS) were determined in liver homogenates obtained at the end of the treatment period. Results. Statistically significant higher activities of GPx (3.52 ± 0.73 U/mg) and CAT (147.25 ± 15.93 U/mg) were detected in rats fed with fishbased meal in comparison with both the control (GPx: 1.93 ± 0.11 U/mg; CAT: 99.37 ± 10.03 U/mg) and the group fed with milk-based diet (GPx: 1.72 ± 0.52 U/mg; CAT: 104.18 ± 37.49 U/mg). Despite somewhat lower concentration of TBARS in the milk-treated group (0.88 ± 0.23 nmoL/mg), no significant differences were detected in comparison with other groups (the control group: 1.00 ± 0.08 nmoL/mg; the fish-based diet group: 1.13 ± 0.15 nmoL/mg). Conclusion. Diet enriched with fish could improve one’s oxidative status by enhancing activities of antioxidant enzymes in the liver tissue. On the contrary, we failed to obtain results suggesting that milk could serve as a source of dietary antioxidants. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. III41030]

Published
2020
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12. The distributed author and the poetics of complexity : a comparative study of the sagas of Icelanders and Serbian epic poetry

Author

Ranković, Slavica

Subjects
839.63, PN Literature (General)
Abstract

The thesis brings together Íslendingasögur and srpske junačke pesme, two historically and culturally unrelated heroic literatures, literatures that had, nevertheless, converged upon a similar kind of realism. This feature in which they diverge from the earlier European epics - Beowulf, Nibelungenlied, La Chanson de Roland, is the focal point of this study. Rather than examining it solely in terms of verisimilitude and historicism with which it is commonly associated, I am approaching it as an emergent feature (emergent realism) of the non-linear, evolutionary dynamics of their production (i.e. their networked, negotiated authorship), the dynamics I call the distributed author. Although all traditional narratives develop in accordance with this dynamics, their non-linearity is often compromised by Bakhtinian 'centripetal forces' (e.g. centralised state, Church) with an effect of directedness akin to the authorial agency of an individual. The peculiar weakness of such forces in the milieus in which the sagas/Serbian epics grew, encouraged their distributed nature. As a result, they come across as indexes of their own coming into being, preserving, meshing and contrasting the old and the new, the general and the more idiosyncratic perspectives on past events and characters. In so doing they fail to arouse in the recipient the feeling of being addressed and possibly manipulated by an all encompassing organising authority. As a consequence, they also impress as believable. While chapters one and two of this study deal with theoretical and aesthetic implications of the two literatures' distributed authorship and their emergent realism, chapters three and four illustrate the ways in which these are manifested in the rich texture of the past and the complex make-up of the characters. The final chapter summarises major points of the thesis and suggests the poetics of complexity as a term particularly suitable to encapsulate the two literatures' common creative principles.

Published
2006

16. Effects of Aronia melanocarpa juice on plasma and liver phospholipid fatty acid composition in Wistar rats

Author

Zec Manja, Debeljak Martačić Jasmina, Ranković Slavica, Pokimica Biljana, Tomić Mirko, Ignjatović Đurđica, Glibetić Maria, and Popović Tamara

Subjects
chokeberry, polyphenols, low-density lipoprotein, arachidonic acid, monounsaturated fatty acids, Veterinary medicine, SF600-1100
Abstract

A nutritional placebo-controlled study was performed in Wistar rats in order to investigate the effects of 5-weeks aronia juice consumption towards fatty acid (FA) composition of phospholipids in the plasma and liver, as well as plasma glucose (Glu) and cholesterol levels. The animals were divided into 3 groups of 8 animals each, and randomized to receive either the full polyphenol dose of Aronia melanocarpa juice (AMJ), 4 times less polyphenol dose (¼-AMJ) or polyphenol-lacking placebo beverage (PLB). Each group of 8 male adult Wistar rats received the liquid ad libitum. AMJ decreased the levels of low-density lipoprotein (LDL) (P < 0.05) vs. PLB. AMJ increased dihomo-γ-linoleic acid (DGLA, 20:3n-6) (P < 0.05) and decreased arachidonic acid content (AA, 20:4n-6) (P < 0.05) vs. PLB in liver phospholipids. AMJ significantly increased monounsaturated fatty acids (MUFA) levels both in the liver (P < 0.05) and plasma (P < 0.05). Both aronia juice doses elevated the levels of beneficial n-3 polyunsaturated fatty acids (PUFA) in the plasma and liver. There was a dose-dependent, significant increase (P < 0.001) in cis-vaccenic acid (VA, 18:1n-7) in phospholipids in the plasma and liver. Our results indicate favorable effects of aronia juice intake on lipid parameters in Wistar rats. These findings suggest the potential of aronia dietary intake in cardiometabolic diseases primary prevention strategies in the human population.

Published
2017
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18. Exposure to Phosphates and Nitrites through Meat Products: Estimation of the Potential Risk to Pregnant Women

Author

Vranić, Danijela, Milešević, Jelena, Trbović, Dejana, Gurinović, Mirjana, Korićanac, Vladimir, Zeković, Milica, Petrović, Zoran, Ranković, Slavica, and Milićević, Dragan

Subjects
food additives, nitrites, phosphates, exposure assessment, meat products, pregnant women
Abstract

Diet during pregnancy is one of the most important nutritional challenges associated with some risks for the mother and the fetus. For the first time, the study aims to estimate long-term (2018–2022) exposure to nitrate and phosphates in Serbian pregnant women, based on individual consumption data and accurate values measured in frequently consumed meat products. For this purpose, seven types of meat products, consisting of 3047 and 1943 samples, were collected from retail markets across Serbia, to analyze nitrites and phosphorus content, respectively. These data were combined with meat product consumption data from the Serbian National Food Consumption Survey to assess dietary intake of nitrites and phosphate. The results were compared with the acceptable daily intake (ADI) proposed by the European Food Safety Authority. The average dietary exposure (EDI) to phosphorus ranged from 0.733 mg/kg bw/day (liver sausage and pate) to 2.441 mg/kg bw/day (finely minced cooked sausages). Considering nitrite intake, the major sources were bacon (0.030 mg/kg bw/day) and coarsely minced cooked sausages (0.0189 mg/kg bw/day). In our study, average nitrite and phosphorus exposure in the Serbian pregnant women population are far below the EFSA recommendations (ADI 0.07 mg/kg bw/day and 40 mg/kg bw/day, respectively).

Published
2023

27. Uticaj različitih vrsta hrane na parametre oksidativnog stresa i masnokiselinski profil fosfolipida jetre pacova

Author

Ranković, Slavica, Popović, Tamara, Vujović, Predrag, Lozo, Jelena, Glibetić, Marija, and Debeljak-Martačić, Jasmina

Subjects
antioksidativni enzimi, pol, pacovi, Fish based diet, lipidna peroksidacija, lipid peroxidation, fatty acids, Hrana obogaćena ribljim brašnom, Wistar rats, milk based diet, antioxidant enzymes, hrana obogaćena mlekom u prahu, gender, masne kiseline
Abstract

Sastav masnih kiselina lipida, posebno fosfolipida (PL) glavnih konstituenata ćelijskih membrana zavisi od brojnih faktora. U poslednje vreme povećano je interesovanje za istraživanja novih antioksidanasa u ishrani, uključujući omega-3 masne kiseline i bioaktivne proteine prisutne u mleku. Uticaj različitih vrsta hrane, odnosno njihovog masnokiselinskog sastava na profil masnih kiselina fosfolipida tkiva nije dovoljno ispitivan. Stoga, cilj ove doktorske disertacije je bio ispitivanje efekta unosa tri različite vrste hrane (standardne hrane, hrane obogaćene ribljim brašnom i hrane obogaćene mlekom u prahu) na biohemijske parametre u krvi, masnokiselinske profile fosfolipida jetre i na parametre oksidativnog stresa u jetri pacova Wistar soja, starosne dobi četiri meseca u trajanju od četiri nedelje. U okviru ove studije, poređen je manokiselinski profil u hranama različitog sastava, a takođe i u fosfolipidima jetri životinja nakon tretmana. Preciznije, cilj je bio izdvajanje pojedinačnih masnih kiselina, koje su najviše doprinele razlici u sastavu fosfolipida jetre, kao i ispitivanje polno specifičnog odgovora tkiva na primenjene vrste hrane. Rezultati ove disertacije su pokazali da hrana obogaćena ribljim brašnom i hrana obogaćena mlekom u prahu menja sastav masnih kiselina fosfolipida i njihov odnos u jetri pacova, na polno specifičan način. Primenjene hrane su promenile odnos ukupnih zasićenih (SFA), mononezasićenih (MUFA) i polinezasićenih masnih kiselina (PUFA), ali su efekti polno specifični. Hrana obogaćena mlekom u prahu je smanjila sadržaj SFA i povećala udeo MUFA kod mužjaka, i PUFA kod ženki, u odnosu na standardnu hranu. Ista vrsta hrane je smanjila procenat ukupnih n-3, povećala procenat ukupnih n-6 i odnos n-6/n-3 kod mužjaka u odnosu na druge vrste hrana. S druge strane, kod ženki, hrana obogaćena ribljim brašnom povećala je procenat ukupnih n-3, smanjila procenat ukupnih n-6 i odnos n-6/n-3 u poređenju sa standardnom hranom i hranom obogaćenom mlekom u prahu. Hrana je na polno specifičan način uticala i na odnos pojedinačnih masnih kiselina u PL jetre... The composition of fatty acids especially phospholipids (PL) as the main constituents of cell membranes depends on many factors. Recently, there has been an increased interest in novel dietary antioxidants, including omega-3 fatty acids and bioactive proteins present in milk. There is limited data regarding the effects of fatty acid composition of different types of diets on tissue phospholipids fatty acid profile. The aim of this doctoral dissertation was to examine the effects of different types of diets (standard diet, fish based and milk based diets) on plasma biochemical parameters, FA profiles of liver phospholipids, and parameters of oxidative stress in liver, of four months old Wistar rats, during four-weeks. Within this study, fatty acid profile was compared in diets of different composition, as well as in liver phospholipids of animals after treatment. The aim was to detect individual fatty acids mostly contributed to the difference in composition of liver phospholipids, and to explore the association of tissue response with gender. The results of this dissertation have shown that both, milk- and fish-based diet, changed the composition and ratio of rat liver phospholipids FA, in gender-specific manner. Although, applied diets changed the ratio of total saturated fatty acids (SFA), monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA), but the effects were sex specific. Milk-based diet lowered the amount of SFA and elevated the ratio of MUFA in males, and PUFA, in females comparing to standard diet. The same diet decreased n-3, increased n-6 and n-6/n-3 ratio in males comparing to the other type of diets. On the other hand, in females, fish-based diet increased n-3, decreased n-6 and n-6/n-3 ratio comparing to standard and milk-based diet. However, the ratio of individual FA in liver PL was also dietary-influenced, but with gender specific manner. While in females fish-based diet decreased AA (arachidonic acid) increased level of EPA (eicosapentaenoic acid), DPA (docosapentaenoic acid) and DHA (docosahexaenoic acid), the same diet elevated only DHA levels in males...

Published
2018

28. Effects of different types of diets on the parameters of oxidative stress and the fatty acid profile of rat liver phospholipids

Author

Ranković, Slavica G., Popović, Tamara B., Vujović, Predrag, Lozo, Jelena, Glibetić, Marija, and Debeljak-Martačić, Jasmina

Subjects
antioksidativni enzimi, pol, Fish based diet, pacovi, lipidna peroksidacija, lipid peroxidation, fatty acids, Hrana obogaćena ribljim brašnom, Wistar rats, milk based diet, antioxidant enzymes, hrana obogaćena mlekom u prahu, gender, masne kiseline
Abstract

The composition of fatty acids especially phospholipids (PL) as the main constituents of cell membranes depends on many factors. Recently, there has been an increased interest in novel dietary antioxidants, including omega-3 fatty acids and bioactive proteins present in milk. There is limited data regarding the effects of fatty acid composition of different types of diets on tissue phospholipids fatty acid profile. The aim of this doctoral dissertation was to examine the effects of different types of diets (standard diet, fish based and milk based diets) on plasma biochemical parameters, FA profiles of liver phospholipids, and parameters of oxidative stress in liver, of four months old Wistar rats, during four-weeks. Within this study, fatty acid profile was compared in diets of different composition, as well as in liver phospholipids of animals after treatment. The aim was to detect individual fatty acids mostly contributed to the difference in composition of liver phospholipids, and to explore the association of tissue response with gender. The results of this dissertation have shown that both, milk- and fish-based diet, changed the composition and ratio of rat liver phospholipids FA, in gender-specific manner. Although, applied diets changed the ratio of total saturated fatty acids (SFA), monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA), but the effects were sex specific. Milk-based diet lowered the amount of SFA and elevated the ratio of MUFA in males, and PUFA, in females comparing to standard diet. The same diet decreased n-3, increased n-6 and n-6/n-3 ratio in males comparing to the other type of diets. On the other hand, in females, fish-based diet increased n-3, decreased n-6 and n-6/n-3 ratio comparing to standard and milk-based diet. However, the ratio of individual FA in liver PL was also dietary-influenced, but with gender specific manner. While in females fish-based diet decreased AA (arachidonic acid) increased level of EPA (eicosapentaenoic acid), DPA (docosapentaenoic acid) and DHA (docosahexaenoic acid), the same diet elevated only DHA levels in males... Sastav masnih kiselina lipida, posebno fosfolipida (PL) glavnih konstituenata ćelijskih membrana zavisi od brojnih faktora. U poslednje vreme povećano je interesovanje za istraživanja novih antioksidanasa u ishrani, uključujući omega-3 masne kiseline i bioaktivne proteine prisutne u mleku. Uticaj različitih vrsta hrane, odnosno njihovog masnokiselinskog sastava na profil masnih kiselina fosfolipida tkiva nije dovoljno ispitivan. Stoga, cilj ove doktorske disertacije je bio ispitivanje efekta unosa tri različite vrste hrane (standardne hrane, hrane obogaćene ribljim brašnom i hrane obogaćene mlekom u prahu) na biohemijske parametre u krvi, masnokiselinske profile fosfolipida jetre i na parametre oksidativnog stresa u jetri pacova Wistar soja, starosne dobi četiri meseca u trajanju od četiri nedelje. U okviru ove studije, poređen je manokiselinski profil u hranama različitog sastava, a takođe i u fosfolipidima jetri životinja nakon tretmana. Preciznije, cilj je bio izdvajanje pojedinačnih masnih kiselina, koje su najviše doprinele razlici u sastavu fosfolipida jetre, kao i ispitivanje polno specifičnog odgovora tkiva na primenjene vrste hrane. Rezultati ove disertacije su pokazali da hrana obogaćena ribljim brašnom i hrana obogaćena mlekom u prahu menja sastav masnih kiselina fosfolipida i njihov odnos u jetri pacova, na polno specifičan način. Primenjene hrane su promenile odnos ukupnih zasićenih (SFA), mononezasićenih (MUFA) i polinezasićenih masnih kiselina (PUFA), ali su efekti polno specifični. Hrana obogaćena mlekom u prahu je smanjila sadržaj SFA i povećala udeo MUFA kod mužjaka, i PUFA kod ženki, u odnosu na standardnu hranu. Ista vrsta hrane je smanjila procenat ukupnih n-3, povećala procenat ukupnih n-6 i odnos n-6/n-3 kod mužjaka u odnosu na druge vrste hrana. S druge strane, kod ženki, hrana obogaćena ribljim brašnom povećala je procenat ukupnih n-3, smanjila procenat ukupnih n-6 i odnos n-6/n-3 u poređenju sa standardnom hranom i hranom obogaćenom mlekom u prahu. Hrana je na polno specifičan način uticala i na odnos pojedinačnih masnih kiselina u PL jetre...

Published
2018

30. Liver phospholipids fatty acids composition in response to different types of diets in rats of both sexes

Author

Ranković, Slavica G. and Ranković, Slavica G.

Abstract

Background: Dietary intake influence changes in fatty acids (FA) profiles in liver which plays a central role in fatty acid metabolism, triacylglycerol synthesis and energy homeostasis. We investigated the effects of 4-weeks treatment with milk-and fish-based diet, on plasma biochemical parameters and FA composition of liver phospholipids (PL) in rats of both sexes. Methods: Adult, 4 months old, Wistar rats of both sexes, were fed with different types of diets: standard, milk-based and fish-based, during 4 weeks. Analytical characterization of different foods was done. Biochemical parameters in plasma were determined. Fatty acid composition was analyzed by gas-chromatography. Statistical significance of FA levels was tested with two-way analysis of variance (ANOVA) using the sex of animals and treatment (type of diet) as factors on logarithmic or trigonometric transformed data. Results: Our results showed that both, milk-and fish-based diet, changed the composition and ratio of rat liver phospholipids FA, in gender-specific manner. Initially present sex differences appear to be dietary modulated. Although, applied diets changed the ratio of total saturated fatty acids (SFA), monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA), and effects were gender specific. Milk-based diet lowered SFA and elevated MUFA in males and increased PUFA in females vs. standard diet. The same diet decreased n-3, increased n-6 and n-6/n-3 ratio in males. Fish-based diet increased n-3, decreased n-6 and n-6/n-3 ratio vs. standard and milk-based diet in females. However, the ratio of individual FA in liver PL was also dietary-influenced, but with gender specific manner. While in females fish-based diet decreased AA (arachidonic acid) increased level of EPA (eicosapentaenoic acid), DPA (docosapentaenoic acid) and DHA (docosahexaenoic acid), the same diet elevated only DHA levels in males. Conclusion: Gender related variations in FA composition of rat liver PL were obser

Published
2017

32. Influence of physical activity on fatty acid profile

Author

Petrović-Oggiano, Gordana P., Debeljak-Martačić, Jasmina, Gurinović, Mirjana A., Popović, Tamara B., Ristić-Medić, Danijela K., Ranković, Slavica G., Takić, Marija, Vučić, Vesna M., Petrović, Snježana B., and Glibetić, Marija

Subjects
Fatty acid profile, cardiometabolic risk, fat metabolism, physical activity
Published
2015

37. Effects of Aronia melanocarpajuice on plasma and liver phospholipid fatty acid composition in Wistar rats

Author

Zec, Manja, Debeljak Martačić, Jasmina, Ranković, Slavica, Pokimica, Biljana, Tomić, Mirko, Ignjatović, Đurđica, Glibetić, Maria, and Popović, Tamara

Abstract

A nutritional placebo-controlled study was performed in Wistar rats in order to investigate the effects of 5-weeks aronia juice consumption towards fatty acid (FA) composition of phospholipids in the plasma and liver, as well as plasma glucose (Glu) and cholesterol levels. The animals were divided into 3 groups of 8 animals each, and randomized to receive either the full polyphenol dose of Aronia melanocarpajuice (AMJ), 4 times less polyphenol dose (¼-AMJ) or polyphenol-lacking placebo beverage (PLB). Each group of 8 male adult Wistar rats received the liquid ad libitum.AMJ decreased the levels of low-density lipoprotein (LDL) (P < 0.05) vs. PLB. AMJ increased dihomo-γ-linoleic acid (DGLA, 20:3n-6) (P < 0.05) and decreased arachidonic acid content (AA, 20:4n-6) (P < 0.05) vs. PLB in liver phospholipids. AMJ significantly increased monounsaturated fatty acids (MUFA) levels both in the liver (P < 0.05) and plasma (P < 0.05). Both aronia juice doses elevated the levels of beneficial n-3 polyunsaturated fatty acids (PUFA) in the plasma and liver. There was a dose-dependent, significant increase (P < 0.001) in cis-vaccenic acid (VA, 18:1n-7) in phospholipids in the plasma and liver. Our results indicate favorable effects of aronia juice intake on lipid parameters in Wistar rats. These findings suggest the potential of aronia dietary intake in cardiometabolic diseases primary prevention strategies in the human population.

Published
2017
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38. Chokeberry Juice Containing Polyphenols Does Not Affect Cholesterol or Blood Pressure but Modifies the Composition of Plasma Phospholipids Fatty Acids in Individuals at Cardiovascular Risk.

Author

Pokimica, Biljana, García-Conesa, María-Teresa, Zec, Manja, Debeljak-Martačić, Jasmina, Ranković, Slavica, Vidović, Nevena, Petrović-Oggiano, Gordana, Konić-Ristić, Aleksandra, and Glibetić, Maria

Abstract

Chokeberry polyphenols have been suggested to reduce cholesterol and blood pressure and thus protect against cardiovascular diseases (CVD), but the evidence in humans is limited and inconsistent. This randomized double-blinded three-parallel groups trial investigated the changes in various anthropometric and clinical biomarkers, and in plasma phospholipids fatty acids (PPFA) in volunteers at cardiovascular risk after a four-week intervention with 100 mL/day of (1) chokeberry juice with a high-dose of polyphenols (1177.11 mg gallic acid equivalents, GAE); (2) chokeberry juice with a low-dose of polyphenols (294.28 mg GAE) and; (3) a nutritionally matched polyphenol-free placebo drink. Our results indicate that the intake of chokeberry juice containing either the low or the high dose of polyphenols cannot be linked with a reduction in total- and low-density lipoprotein (LDL)cholesterol or in systolic (SBP) and diastolic (DBP) blood pressure in comparison with the consumption of the placebo drink. However, we found evidence of moderate changes in the PPFA, i.e., increased saturated fatty acids (SFA), mostly palmitic acid, and reduced n-6 polyunsaturated fatty acids (PUFA), principally linoleic acid (LA) with the intake of chokeberry against the placebo. These effects may be associated with the polyphenols but we could not differentiate a clear dose-response effect. Further research is still needed to elucidate the contribution of the polyphenolic fraction to the potential cardiovascular effects of the chokeberry and to build up the evidence of its potential benefit via the modulation of PPFA composition. [ABSTRACT FROM AUTHOR]

Published
2019
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