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199 results on '"Ranjeva, J"'

2. Artificial intelligence to predict clinical disability in patients with multiple sclerosis using FLAIR MRI

Author

Brochet, B., Casey, R., Cotton, F., De Sèze, J., Douek, P., Guillemin, F., Laplaud, D., Lebrun-Frenay, C., Mansuy, L., Moreau, T., Olaiz, J., Pelletier, J., Rigaud-Bully, C., Stankoff, B., Vukusic, S., Marignier, R., Debouverie, M., Edan, G., Ciron, J., Ruet, A., Collongues, N., Lubetzki, C., Vermersch, P., Labauge, P., Defer, G., Cohen, M., Fromont, A., Wiertlewsky, S., Berger, E., Clavelou, P., Audoin, B., Giannesini, C., Gout, O., Thouvenot, E., Heinzlef, O., Al-Khedr, A., Bourre, B., Casez, O., Cabre, P., Montcuquet, A., Créange, A., Camdessanché, J.-P., Faure, J., Maurousset, A., Patry, I., Hankiewicz, K., Pottier, C., Maubeuge, N., Labeyrie, C., Nifle, C., Ameli, R., Anxionnat, R., Attye, A., Bannier, E., Barillot, C., Ben Salem, D., Boncoeur-Martel, M.-P., Bonneville, F., Boutet, C., Brisset, J.-C., Cervenanski, F., Claise, B., Commowick, O., Constans, J.-M., Dardel, P., Desal, H., Dousset, Vincent, Durand-Dubief, F., Ferre, J.-C., Gerardin, E., Glattard, T., Grand, S., Grenier, T., Guillevin, R., Guttmann, C., Krainik, A., Kremer, S., Lion, S., Menjot de Champfleur, N., Mondot, L., Outteryck, O., Pyatigorskaya, N., Pruvo, J.-P., Rabaste, S., Ranjeva, J.-P., Roch, J.-A., Sadik, J.C., Sappey-Marinier, D., Savatovsky, J., Tanguy, J.-Y., Tourbah, A., Tourdias, T., Roca, P., Colas, L., Tucholka, A., Rubini, P., Cackowski, S., Ding, J., Budzik, J.-F., Renard, F., Doyle, S., Barbier, E.L., Bousaid, I., Lassau, N., and Verclytte, S.

Published
2020
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5. Central Nervous System

Author

Berry, I., Ranjeva, J.-P., Clanet, M., Manelfe, C., Thomsen, Henrick S., editor, Muller, Robert N., editor, and Mattrey, Robert F., editor

Published
1999
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7. Clinical and biomarker profiling of prodromal Alzheimerʼs disease in workpackage 5 of the Innovative Medicines Initiative PharmaCog project: a ‘European ADNI study’

Author

Galluzzi, S., Marizzoni, M., Babiloni, C., Albani, D., Antelmi, L., Bagnoli, C., Bartres-Faz, D., Cordone, S., Didic, M., Farotti, L., Fiedler, U., Forloni, G., Girtler, N., Hensch, T., Jovicich, J., Leeuwis, A., Marra, C., Molinuevo, J. L., Nobili, F., Pariente, J., Parnetti, L., Payoux, P., Del Percio, C., Ranjeva, J.-P., Rolandi, E., Rossini, P. M., Schönknecht, P., Soricelli, A., Tsolaki, M., Visser, P. J., Wiltfang, J., Richardson, J. C., Bordet, R., Blin, O., and Frisoni, G. B.

Published
2016
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9. Clinical Whole-Brain R2* and Quantitative Susceptibility Maps at 3T -Reproducibility and Parameter Optimization Towards Millimetric 5min Scan

Author

Troalen, T, Le Troter, A, Confort-Gouny, S, Vioux, P, Costes, C, Pini, L, Ranjeva, J, Guye, M, de Rochefort, Ludovic, Siemens Healthcare SAS, Saint-Denis, France, Centre de résonance magnétique biologique et médicale (CRMBM), Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Siemens Healthcare [France], Siemens AG [Munich], and Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Clinical Application, Data Processing, Susceptibility, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Brain
Abstract

International audience; Advanced reconstruction techniques allow to jointly estimate R2* and QSM in the brain from multi gradient-recalled echo sequences. This work aims at comparing several protocols in terms of coil setup and acceleration factors using available product sequences and modern hardware. In addition, an automatic and standardized post-processing pipeline is proposed for clinical studies. We show that quantitative values do not differ in terms of head coil, repetition time and acceleration factor used, thus allowing for a millimetric whole-brain coverage within 5 minutes scan time.

Published
2021

10. Accuracy and reproducibility of automated white matter hyperintensities segmentation with lesion segmentation tool: A European multi-site 3T study

Author

Ribaldi, F., Altomare, D., Jovicich, J., Ferrari, C., Picco, A., Pizzini, F. B., Soricelli, A., Mega, A., Ferretti, A., Drevelegas, A., Bosch, B., Muller, B. W., Marra, Camillo, Cavaliere, C., Bartres-Faz, D., Nobili, F., Alessandrini, F., Barkhof, F., Gros-Dagnac, H., Ranjeva, J. -P., Wiltfang, J., Kuijer, J., Sein, J., Hoffmann, K. -T., Roccatagliata, L., Parnetti, L., Tsolaki, M., Constantinidis, M., Aiello, M., Salvatore, M., Montalti, M., Caulo, M., Didic, M., Bargallo, N., Blin, O., Rossini, Paolo Maria, Schonknecht, P., Floridi, P., Payoux, P., Visser, P. J., Bordet, R., Lopes, R., Tarducci, R., Bombois, S., Hensch, T., Fiedler, U., Richardson, J. C., Frisoni, G. B., Marizzoni, M., Marra C. (ORCID:0000-0003-3994-4044), Rossini P. M. (ORCID:0000-0003-2665-534X), Ribaldi, F., Altomare, D., Jovicich, J., Ferrari, C., Picco, A., Pizzini, F. B., Soricelli, A., Mega, A., Ferretti, A., Drevelegas, A., Bosch, B., Muller, B. W., Marra, Camillo, Cavaliere, C., Bartres-Faz, D., Nobili, F., Alessandrini, F., Barkhof, F., Gros-Dagnac, H., Ranjeva, J. -P., Wiltfang, J., Kuijer, J., Sein, J., Hoffmann, K. -T., Roccatagliata, L., Parnetti, L., Tsolaki, M., Constantinidis, M., Aiello, M., Salvatore, M., Montalti, M., Caulo, M., Didic, M., Bargallo, N., Blin, O., Rossini, Paolo Maria, Schonknecht, P., Floridi, P., Payoux, P., Visser, P. J., Bordet, R., Lopes, R., Tarducci, R., Bombois, S., Hensch, T., Fiedler, U., Richardson, J. C., Frisoni, G. B., Marizzoni, M., Marra C. (ORCID:0000-0003-3994-4044), and Rossini P. M. (ORCID:0000-0003-2665-534X)

Abstract

Brain vascular damage accumulate in aging and often manifest as white matter hyperintensities (WMHs) on MRI. Despite increased interest in automated methods to segment WMHs, a gold standard has not been achieved and their longitudinal reproducibility has been poorly investigated. The aim of present work is to evaluate accuracy and reproducibility of two freely available segmentation algorithms. A harmonized MRI protocol was implemented in 3T-scanners across 13 European sites, each scanning five volunteers twice (test-retest) using 2D-FLAIR. Automated segmentation was performed using Lesion segmentation tool algorithms (LST): the Lesion growth algorithm (LGA) in SPM8 and 12 and the Lesion prediction algorithm (LPA). To assess reproducibility, we applied the LST longitudinal pipeline to the LGA and LPA outputs for both the test and retest scans. We evaluated volumetric and spatial accuracy comparing LGA and LPA with manual tracing, and for reproducibility the test versus retest. Median volume difference between automated WMH and manual segmentations (mL) was −0.22[IQR = 0.50] for LGA-SPM8, −0.12[0.57] for LGA-SPM12, −0.09[0.53] for LPA, while the spatial accuracy (Dice Coefficient) was 0.29[0.31], 0.33[0.26] and 0.41[0.23], respectively. The reproducibility analysis showed a median reproducibility error of 20%[IQR = 41] for LGA-SPM8, 14% [31] for LGA-SPM12 and 10% [27] with the LPA cross-sectional pipeline. Applying the LST longitudinal pipeline, the reproducibility errors were considerably reduced (LGA: 0%[IQR = 0], p < 0.001; LPA: 0% [3], p < 0.001) compared to those derived using the cross-sectional algorithms. The DC using the longitudinal pipeline was excellent (median = 1) for LGA [IQR = 0] and LPA [0.02]. LST algorithms showed moderate accuracy and good reproducibility. Therefore, it can be used as a reliable cross-sectional and longitudinal tool in multi-site studies.

Published
2021

11. Cross-sectional clinical, neuropsychological, neuroimaging, and neurophysiological characterization of mild cognitive impairment patients in WP5 PharmaCog/E-ADNI study: EP1105

Author

Galluzzi, S., Marizzoni, M., Babiloni, C., Bartres-Faz, D., Blin, O., Bordet, R., Bosch, B., De Anna, F., Didic, M., Farotti, L., Forloni, G., Jovicich, J., Marra, C., Marzano, N., Molinuevo, J. L., Nobili, F., Pariente, J., Parnetti, L., Payoux, P., Picco, A., Quaranta, D., Ranjeva, J.-P., Roccatagliata, L., Rossini, P. M., Salvadori, N., Schonknecht, P., Soricelli, A., Tsolaki, M., Vecchio, F., Visser, P. J., Wiltfang, J., and Frisoni, G. B.

Published
2014

16. Artificial intelligence to predict clinical disability in patients with multiple sclerosis using FLAIR MRI

Author

Roca, P., primary, Attye, A., additional, Colas, L., additional, Tucholka, A., additional, Rubini, P., additional, Cackowski, S., additional, Ding, J., additional, Budzik, J.-F., additional, Renard, F., additional, Doyle, S., additional, Barbier, E.L., additional, Bousaid, I., additional, Casey, R., additional, Vukusic, S., additional, Lassau, N., additional, Verclytte, S., additional, Cotton, F., additional, Brochet, B., additional, De Sèze, J., additional, Douek, P., additional, Guillemin, F., additional, Laplaud, D., additional, Lebrun-Frenay, C., additional, Mansuy, L., additional, Moreau, T., additional, Olaiz, J., additional, Pelletier, J., additional, Rigaud-Bully, C., additional, Stankoff, B., additional, Marignier, R., additional, Debouverie, M., additional, Edan, G., additional, Ciron, J., additional, Ruet, A., additional, Collongues, N., additional, Lubetzki, C., additional, Vermersch, P., additional, Labauge, P., additional, Defer, G., additional, Cohen, M., additional, Fromont, A., additional, Wiertlewsky, S., additional, Berger, E., additional, Clavelou, P., additional, Audoin, B., additional, Giannesini, C., additional, Gout, O., additional, Thouvenot, E., additional, Heinzlef, O., additional, Al-Khedr, A., additional, Bourre, B., additional, Casez, O., additional, Cabre, P., additional, Montcuquet, A., additional, Créange, A., additional, Camdessanché, J.-P., additional, Faure, J., additional, Maurousset, A., additional, Patry, I., additional, Hankiewicz, K., additional, Pottier, C., additional, Maubeuge, N., additional, Labeyrie, C., additional, Nifle, C., additional, Ameli, R., additional, Anxionnat, R., additional, Bannier, E., additional, Barillot, C., additional, Ben Salem, D., additional, Boncoeur-Martel, M.-P., additional, Bonneville, F., additional, Boutet, C., additional, Brisset, J.-C., additional, Cervenanski, F., additional, Claise, B., additional, Commowick, O., additional, Constans, J.-M., additional, Dardel, P., additional, Desal, H., additional, Dousset, Vincent, additional, Durand-Dubief, F., additional, Ferre, J.-C., additional, Gerardin, E., additional, Glattard, T., additional, Grand, S., additional, Grenier, T., additional, Guillevin, R., additional, Guttmann, C., additional, Krainik, A., additional, Kremer, S., additional, Lion, S., additional, Menjot de Champfleur, N., additional, Mondot, L., additional, Outteryck, O., additional, Pyatigorskaya, N., additional, Pruvo, J.-P., additional, Rabaste, S., additional, Ranjeva, J.-P., additional, Roch, J.-A., additional, Sadik, J.C., additional, Sappey-Marinier, D., additional, Savatovsky, J., additional, Tanguy, J.-Y., additional, Tourbah, A., additional, and Tourdias, T., additional

Published
2020
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19. New OFSEP recommendations for MRI assessment of multiple sclerosis patients: Special consideration for gadolinium deposition and frequent acquisitions

Author

Brisset, Jean-Christophe, primary, Kremer, Stephane, additional, Hannoun, Salem, additional, Bonneville, Fabrice, additional, Durand-Dubief, Francoise, additional, Tourdias, Thomas, additional, Barillot, Christian, additional, Guttmann, Charles, additional, Vukusic, Sandra, additional, Dousset, Vincent, additional, Cotton, Francois, additional, Ameli, R., additional, Anxionnat, R., additional, Audoin, B., additional, Attye, A., additional, Bannier, E., additional, Barillot, C., additional, Ben Salem, D., additional, Boncoeur-Martel, M.-P., additional, Bonhomme, G., additional, Bonneville, F., additional, Boutet, C., additional, Brisset, J.C., additional, Cervenanski, F., additional, Claise, B., additional, Commowick, O., additional, Constans, J.-M., additional, Cotton, F., additional, Dardel, P., additional, Desal, H., additional, Dousset, V., additional, Durand-Dubief, F., additional, Ferre, J.-C., additional, Gaultier, A., additional, Gerardin, E., additional, Glattard, T., additional, Grand, S., additional, Grenier, T., additional, Guillevin, R., additional, Guttmann, C., additional, Krainik, A., additional, Kremer, S., additional, Lion, S., additional, Champfleur, N. Menjot De, additional, Mondot, L., additional, Outteryck, O., additional, Pyatigorskaya, N., additional, Pruvo, J.-P., additional, Rabaste, S., additional, Ranjeva, J.-P., additional, Roch, J.-A., additional, Sadik, J.-C., additional, Sappey-Marinier, D., additional, Savatovsky, J., additional, Stankoff, B., additional, Tanguy, J.-Y., additional, Tourbah, A., additional, Tourdias, T., additional, Brochet, B., additional, Casey, R., additional, De Sèze, J., additional, Douek, P., additional, Guillemin, F., additional, Laplaud, D., additional, Lebrun-Frenay, C., additional, Mansuy, L., additional, Moreau, T., additional, Olaiz, J., additional, Pelletier, J., additional, Rigaud-Bully, C., additional, Vukusic, S., additional, Debouverie, M., additional, Edan, G., additional, Ciron, J., additional, Lubetzki, C., additional, Vermersch, P., additional, Labauge, P., additional, Defer, G., additional, Berger, E., additional, Clavelou, P., additional, Gout, O., additional, Thouvenot, E., additional, Heinzlef, O., additional, Al-Khedr, A., additional, Bourre, B., additional, Casez, O., additional, Cabre, P., additional, Montcuquet, A., additional, Créange, A., additional, Camdessanché, J.-P., additional, Bakchine, S., additional, Maurousset, A., additional, Patry, I., additional, De Broucker, T., additional, Pottier, C., additional, Neau, J.-P., additional, Labeyrie, C., additional, and Nifle, C., additional

Published
2020
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32. New brain lesions with no impact on physical disability can impact cognition in early multiple sclerosis: A ten-year longitudinal study

Author

Wybrecht, D., primary, Reuter, F., additional, Pariollaud, F., additional, Zaaraoui, W., additional, Le Troter, A., additional, Rico, A., additional, Confort-Gouny, S., additional, Soulier, E., additional, Guye, M., additional, Maarouf, A., additional, Ranjeva, J-P., additional, Pelletier, J., additional, and Audoin, B., additional

Published
2017
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33. Longitudinal reproducibility of default-mode network connectivity in healthy elderly participants: A multicentric resting-state fMRI study

Author

Jovicich, J, Minati, L, Marizzoni, M, Marchitelli, R, Sala Llonch, R, Bartrés Faz, D, Arnold, J, Benninghoff, J, Fiedler, U, Roccatagliata, L, Picco, A, Nobili, F, Blin, O, Bombois, S, Lopes, R, Bordet, R, Sein, J, Ranjeva, J, Didic, M, Gros Dagnac, H, Payoux, P, Zoccatelli, G, Alessandrini, F, Beltramello, A, Bargalló, N, Ferretti, A, Caulo, M, Aiello, M, Cavaliere, C, Soricelli, A, Parnetti, L, Tarducci, R, Floridi, P, Tsolaki, M, Constantinidis, M, Drevelegas, A, Rossini, Paolo Maria, Marra, Camillo, Schönknecht, P, Hensch, T, Hoffmann, K, Kuijer, Jp, Visser, Pj, Barkhof, F, Frisoni, Gb, Rossini, Paolo Maria (ORCID:0000-0003-2665-534X), Marra, Camillo (ORCID:0000-0003-3994-4044), Jovicich, J, Minati, L, Marizzoni, M, Marchitelli, R, Sala Llonch, R, Bartrés Faz, D, Arnold, J, Benninghoff, J, Fiedler, U, Roccatagliata, L, Picco, A, Nobili, F, Blin, O, Bombois, S, Lopes, R, Bordet, R, Sein, J, Ranjeva, J, Didic, M, Gros Dagnac, H, Payoux, P, Zoccatelli, G, Alessandrini, F, Beltramello, A, Bargalló, N, Ferretti, A, Caulo, M, Aiello, M, Cavaliere, C, Soricelli, A, Parnetti, L, Tarducci, R, Floridi, P, Tsolaki, M, Constantinidis, M, Drevelegas, A, Rossini, Paolo Maria, Marra, Camillo, Schönknecht, P, Hensch, T, Hoffmann, K, Kuijer, Jp, Visser, Pj, Barkhof, F, Frisoni, Gb, Rossini, Paolo Maria (ORCID:0000-0003-2665-534X), and Marra, Camillo (ORCID:0000-0003-3994-4044)

Abstract

To date, limited data are available regarding the inter-site consistency of test-retest reproducibility of functional connectivity measurements, in particular with regard to integrity of the Default Mode Network (DMN) in elderly participants. We implemented a harmonized resting-state fMRI protocol on 13 clinical scanners at 3.0T using vendor-provided sequences. Each site scanned a group of 5 healthy elderly participants twice, at least a week apart. We evaluated inter-site differences and test-retest reproducibility of both temporal signal-to-noise ratio (tSNR) and functional connectivity measurements derived from: i) seed-based analysis (SBA) with seed in the posterior cingulate cortex (PCC), ii) group independent component analysis (ICA) separately for each site (site ICA), and iii) consortium ICA, with group ICA across the whole consortium. Despite protocol harmonization, significant and quantitatively important inter-site differences remained in the tSNR of resting-state fMRI data; these were plausibly driven by hardware and pulse sequence differences across scanners which could not be harmonized. Nevertheless, the tSNR test-retest reproducibility in the consortium was high (ICC=0.81). The DMN was consistently extracted across all sites and analysis methods. While significant inter-site differences in connectivity scores were found, there were no differences in the associated test-retest error. Overall, ICA measurements were more reliable than PCC-SBA, with site ICA showing higher reproducibility than consortium ICA. Across the DMN nodes, the PCC yielded the most reliable measurements (≈4% test-retest error, ICC=0.85), the medial frontal cortex the least reliable (≈12%, ICC=0.82) and the lateral parietal cortices were in between (site ICA). Altogether these findings support usage of harmonized multisite studies of resting-state functional connectivity to characterize longitudinal effects in studies that assess disease progression and treatment response.

Published
2016

34. Validation of a 2D Spinal Cord Probabilistic Atlas. Application to FA Measurement and VBM Study of the GM Atrophy Occurring with Age

Author

Taso, M., Le Troter, A., Sdika, Michaël, Fonov, V.S., Cohen-Adad, J., Guye, Maxime, Ranjeva, J., Callot, V., Centre d'Exploration Métabolique par Résonance Magnétique [Marseille] (CEMEREM), Hôpital de la Timone [CHU - APHM] (TIMONE), Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Images et Modèles, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service Informatique et développements, McConnell Brain Imaging Centre (MNI), Montreal Neurological Institute and Hospital, McGill University = Université McGill [Montréal, Canada]-McGill University = Université McGill [Montréal, Canada], Institute of Biomedical Engineering, École Polytechnique de Montréal (EPM), Functional Neuroimaging Unit, CRIUGM, Centre de recherche de l'Institut universitaire de gériatrie de Montreal (CRIUGM), Université de Montréal (UdeM)-Université de Montréal (UdeM), Epilepsies, Lesions Cerebrales et Systemes Neuraux de la Cognition, Université de la Méditerranée - Aix-Marseille 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Neurophysiologie Clinique, Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - APHM] (CEMEREM), Hôpital de la Timone [CHU - APHM] (TIMONE)-Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2014

35. Cross-sectional clinical, neuropsychological, neuroimaging, and neurophysiological characterization of mild cognitive impairment patients in WP5 PharmaCog/E-ADNI study

Author

Galluzzi, S., Marizzoni, M., Babiloni, C., Bartres-Faz, D., Blin, O., Bordet, R., Bosch, B., Anna, F., Didic, M., Farotti, L., Forloni, G., Jovicich, J., Marra, C., Marzano, N., Molinuevo, J. L., Nobili, F., Pariente, J., Parnetti, L., Payoux, P., Picco, A., Quaranta, D., Ranjeva, J. P., Roccatagliata, L., Rossini, P. M., Salvadori, N., Schonknecht, P., Andrea Soricelli, Tsolaki, M., Vecchio, F., Visser, P. J., Wiltfang, J., Frisoni, G. B., and Pharmacog, Consortium

Subjects
Medizin, ComputingMethodologies_GENERAL
Abstract

Poster Abstract

Published
2014

36. Longitudinal reproducibility of automatically segmented hippocampal subfields: A multisite European 3T study on healthy elderly

Author

Marizzoni, M, Antelmi, L, Bosch, B, Bartrés-Faz, D, Müller, BW, Wiltfang, J, Fiedler, U, Roccatagliata, L, Picco, A, Nobili, F, Blin, O, Bombois, S, Lopes, R, Sein, J, Ranjeva, J, Didic, M, Gros-Dagnac, H, Payoux, P, Zoccatelli, G, Alessandrini, F, Beltramello, A, Bargalló, N, Ferretti, A, Caulo, M, Aiello, M, Cavaliere, C, Soricelli, A, Salvadori, N, Parnetti, L, Tarducci, R, Floridi, P, Tsolaki, M, Constantinidis, M, Drevelegas, A, ROSSINI, PAOLO MARIA, Marra, C, Hoffmann, K, Hensch, T, Schönknecht, P, Kuijer, JP, Visser, PJ, Barkhof, F, Bordet, R, Frisoni, GB, Jovicich, J, Marizzoni, M, Antelmi, L, Bosch, B, Bartrés-Faz, D, Müller, BW, Wiltfang, J, Fiedler, U, Roccatagliata, L, Picco, A, Nobili, F, Blin, O, Bombois, S, Lopes, R, Sein, J, Ranjeva, J, Didic, M, Gros-Dagnac, H, Payoux, P, Zoccatelli, G, Alessandrini, F, Beltramello, A, Bargalló, N, Ferretti, A, Caulo, M, Aiello, M, Cavaliere, C, Soricelli, A, Salvadori, N, Parnetti, L, Tarducci, R, Floridi, P, Tsolaki, M, Constantinidis, M, Drevelegas, A, ROSSINI, PAOLO MARIA, Marra, C, Hoffmann, K, Hensch, T, Schönknecht, P, Kuijer, JP, Visser, PJ, Barkhof, F, Bordet, R, Frisoni, GB, and Jovicich, J

Published
2015

37. Magnetic Resonance Spectroscopic Imaging Detects Metabolic Changes within the Medial Temporal Lobe in aMCI

Author

Didic, Mira, Ranjeva, J. P., E. J., Barbeau, Confort-Gouny, Sylviane, Felician, Olivier, Fur, Yann Le, Tramoni, E., Mancini, J., Poncet, M., P. J., Cozzone, Ceccaldi, Mathieu, Service de neurologie et de neuropsychologie, Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Centre de recherche cerveau et cognition (CERCO), Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Enseignement et de Recherche sur le Traitement de l'Information Médicale (LERTIM), Université de la Méditerranée - Aix-Marseille 2, Ashford, J. W., Rosen, A., Adamson, M., Bayley, P., Sabri, O., Furst, Black, S. E., Weiner, Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Marlot, Catherine, and Ashford, J. W., Rosen, A., Adamson, M., Bayley, P., Sabri, O., Furst, A., Black, S. E., Weiner, M.

Subjects
mental disorders, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], psychological phenomena and processes
Abstract

There is a critical need for reliable diagnosis of Alzheimer's Disease (AD) at an early stage, as disease modifying agents are being developed, likely to be most efficient when lesions are minimal. Using Magnetic Resonance Spectroscopy (MRS), reflecting metabolic change, the NAA/mIno-ratio has been shown to be reduced in AD and to be associated with the severity of AD pathology on postmortem brain tissue. However, it is not clear if this ratio is reduced in the early stages of AD, especially within the mesial temporal lobe (MTL), where tau pathology first develops in AD. Within the MTL, neurofibrillary tangles, related to clinical signs, first affect the anterior subhippocampal cortex, then the hippocampus during the limbic stage. In the monkey, experimental studies show that the sub-hippocampal cortex is crucial for visual recognition memory (VRM). We previously found that aMCI-patients that are impaired on a VRM task have features of early AD. We assessed metabolic changes by measuring NAA/mIno-ratios within the MTL of patients with amnestic MCI (aMCI), at risk for AD, using MRS Imaging. The MTL was sampled at different levels in order to evaluate its subcomponents. The NAA/mIno-ratio was reduced in the MTL of aMCI patients. However, while these ratios in aMCI-patients with normal VRM did not differ from controls, the subgroup of aMCI patients with impaired VRM scores had reduced MTL NAA/mIno ratios. Moreover, VRM performance was correlated with NAA/mIno levels within the anterior MTL. In addition, clinical follow-up data suggests that patients with impaired VRM are more likely to develop probable AD and MCI converters were found to have metabolic changes in the MTL at baseline in comparison with controls. This confirms that MRS may be useful for the detection of AD at the predementia stage of the disease and that NAA/mIno could be considered as a further biomarker of AD. Moreover, taking into account the cognitive profile is crucial in order to select aMCI patients at very high risk for AD. Finally, this study supports the role of anterior MTL structures in VRM.

Published
2011

38. In vivo MR imaging of brain networks: illusion or revolution?

Author

Moser, E., Ranjeva, J. P., Ben Dahan, David, Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), and Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)

Abstract

0968-5243 (Print) 0968-5243 (Linking) Editorial Introductory Journal Article

Published
2010

39. Multisite longitudinal reliability of tract-based spatial statistics in diffusion tensor imaging of healthy elderly subjects

Author

Jovicich, J, Marizzoni, M, Bosch, B, Bartrés Faz, D, Arnold, J, Benninghoff, J, Wiltfang, J, Roccatagliata, L, Picco, A, Nobili, F, Blin, O, Bombois, S, Lopes, R, Bordet, R, Chanoine, V, Ranjeva, J, Didic, M, Gros Dagnac, H, Payoux, P, Zoccatelli, G, Alessandrini, F, Beltramello, A, Bargalló, N, Ferretti, A, Caulo, M, Aiello, M, Ragucci, M, Soricelli, A, Salvadori, N, Tarducci, R, Floridi, P, Tsolaki, M, Constantinidis, M, Drevelegas, A, Rossini, Paolo Maria, Marra, Camillo, Otto, J, Reiss Zimmermann, M, Hoffmann, K, Galluzzi, S, Frisoni, Gb, Rossini, Paolo Maria (ORCID:0000-0003-2665-534X), Marra, Camillo (ORCID:0000-0003-3994-4044), Jovicich, J, Marizzoni, M, Bosch, B, Bartrés Faz, D, Arnold, J, Benninghoff, J, Wiltfang, J, Roccatagliata, L, Picco, A, Nobili, F, Blin, O, Bombois, S, Lopes, R, Bordet, R, Chanoine, V, Ranjeva, J, Didic, M, Gros Dagnac, H, Payoux, P, Zoccatelli, G, Alessandrini, F, Beltramello, A, Bargalló, N, Ferretti, A, Caulo, M, Aiello, M, Ragucci, M, Soricelli, A, Salvadori, N, Tarducci, R, Floridi, P, Tsolaki, M, Constantinidis, M, Drevelegas, A, Rossini, Paolo Maria, Marra, Camillo, Otto, J, Reiss Zimmermann, M, Hoffmann, K, Galluzzi, S, Frisoni, Gb, Rossini, Paolo Maria (ORCID:0000-0003-2665-534X), and Marra, Camillo (ORCID:0000-0003-3994-4044)

Abstract

Large-scale longitudinal neuroimaging studies with diffusion imaging techniques are necessary to test and validate models of white matter neurophysiological processes that change in time, both in healthy and diseased brains. The predictive power of such longitudinal models will always be limited by the reproducibility of repeated measures acquired during different sessions. At present, there is limited quantitative knowledge about the across-session reproducibility of standard diffusion metrics in 3T multi-centric studies on subjects in stable conditions, in particular when using tract based spatial statistics and with elderly people. In this study we implemented a multi-site brain diffusion protocol in 10 clinical 3T MRI sites distributed across 4 countries in Europe (Italy, Germany, France and Greece) using vendor provided sequences from Siemens (Allegra, Trio Tim, Verio, Skyra, Biograph mMR), Philips (Achieva) and GE (HDxt) scanners. We acquired DTI data (2 × 2 × 2 mm(3), b = 700 s/mm(2), 5 b0 and 30 diffusion weighted volumes) of a group of healthy stable elderly subjects (5 subjects per site) in two separate sessions at least a week apart. For each subject and session four scalar diffusion metrics were considered: fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD) and axial (AD) diffusivity. The diffusion metrics from multiple subjects and sessions at each site were aligned to their common white matter skeleton using tract-based spatial statistics. The reproducibility at each MRI site was examined by looking at group averages of absolute changes relative to the mean (%) on various parameters: i) reproducibility of the signal-to-noise ratio (SNR) of the b0 images in centrum semiovale, ii) full brain test-retest differences of the diffusion metric maps on the white matter skeleton, iii) reproducibility of the diffusion metrics on atlas-based white matter ROIs on the white matter skeleton. Despite the differences of MRI scanner configuratio

Published
2014

50. Détection des anomalies individuelles de la substance grise au stade précoce de la sclérose en plaques par cartographie statistique des cartes de taux de transfert d’aimantation

Author

Audoin, B., primary, Crespy, L., additional, Zaaraoui, W., additional, Lemaire, M., additional, Jure, L., additional, Rico, A., additional, Faivre, A., additional, Reuter, F., additional, Malikova, I., additional, Cozzone, P., additional, Ranjeva, J.-P., additional, and Pelletier, J., additional

Published
2012
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