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A multi-tenant database (MTDB) is the backbone for any cloud app that employs a software as a service (SaaS) delivery paradigm. Every cloud-based SaaS delivery strategy relies heavily on the architecture of multitenant databases. The hardware and performance costs for quicker query execution and space savings provided by the architecture of MTDBs are implementation costs. All tenants’ data may be kept in a single table with a common schema and database format, making it the most cost-effective MTDB configuration. The arrangement becomes congested if tenants have varying storage needs. In this research, we present a space-saving architecture that improves transactional query execution while avoiding the waste of space due to different attribute needs. Extensible markup language (XML) and JavaScript object notation (JSON) compare the proposed system against the state of the art. The suggested multitenant database architecture reduces unnecessary space and improves query performance. The experimental findings show that the suggested system outperforms the state-ofthe-art extension table method. [ABSTRACT FROM AUTHOR]

The pathogens such as fungi and bacteria can lead to rice diseases that can drastically impair crop production. Because the illness is difficult to control on a broad scale, crop field monitoring is one of the most effective methods of control. It allows for early detection of the disease and the implementation of preventative measures. Disease severity estimation based on digital picture analysis, where the pictures are obtained from the rice field using mobile devices, is one of the most effective control strategies. This paper offers a method for quantifying the severity of three rice crop diseases (brown spot, blast, and bacterial blight) that can determine the stage of plant disease. A total of 1200 images of rice illnesses and healthy images make up the input dataset. With the help of agricultural experts, the diseased zone was labeled according to the disease type using the Make Sense tool. More than 75% of the images in the dataset correspond to one disease label, healthy plants represent more than 15%, and multiple diseases represent 5% of the images labeled. This paper proposes a novel artificial intelligence rice grade model that uses an optimized faster-region-based convolutional neural network (FRCNN) approach to calculate the area of leaf instances and the infected regions. EfficientNet-B0 architecture was used as a backbone as the network shows the best accuracy (96.43%). The performance was compared with the CNN architectures: VGG16, ResNet101, and MobileNet. The model evaluation parameters used to measure the accuracy are positive predictive value, sensitivity, and intersection over union. This severity estimation method can be further deployed as a tool that allows farmers to obtain perfect predictions of the disease severity level based on lesions in the field conditions and produce crops more organically. [ABSTRACT FROM AUTHOR]

We investigated the impact of antiviral treatment on the emergence of SARS-CoV-2 resistance during persistent infections in immunocompromised patients (n=15). All patients received remdesivir and some also received nirmatrelvir-ritonavir or monoclonal antibodies. Sequence analysis showed that nine patients carried viruses with mutations in the nsp12 (RNA dependent RNA polymerase), while four had viruses with nsp5 (3C protease) mutations. Infectious SARS-CoV-2 with a double mutation in nsp5 (T169I) and nsp12 (V792I) was recovered from respiratory secretions 77 days after initial COVID-19 diagnosis from a patient treated with remdesivir and nirmatrelvir-ritonavir. In vitro characterization confirmed its decreased sensitivity to remdesivir and nirmatrelvir, which was overcome by combined antiviral treatment. Studies in golden Syrian hamsters demonstrated efficient transmission to contact animals. This study documents the isolation of SARS-CoV-2 carrying resistance mutations to both nirmatrelvir and remdesivir from a patient and demonstrates its transmissibility in vivo .