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2. Association Between Anesthesiologist Sex and Patients’ Postoperative Outcomes: A Population-based Cohort Study

Author

Jerath, Angela, Satkunasivam, Raj, Kaneshwaran, Kirusanthy, Aminoltejari, Khatereh, Chang, Ashton, MacDonell, D. Su-Yin, Kealey, Alayne, Ladowski, Stephanie, Sarmah, Anita, Flexman, Alana M., Lorello, Gianni R., Nabecker, Sabine, Coburn, Natalie, Conn, Lesley G., Klaassen, Zachary, Ranganathan, Sanjana, Riveros, Carlos, McCartney, Colin J.L., Detsky, Allan S., and Wallis, Christopher J.D.

Published
2024
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3. Superstition in Surgery: A Population-Based Cohort Study to Assess the Association Between Surgery on Friday the 13th and Postoperative Outcomes

Author

Ranganathan, Sanjana, Riveros, Carlos, Geng, Michael, Chang, Courtney, Tsugawa, Yusuke, Ravi, Bheeshma, Melchiode, Zachary, Hu, Siqi, Kobashi, Kathleen, Miles, Brian J., Klaassen, Zachary, Nathens, Avery, Coburn, Natalie, Detsky, Allan S., Jerath, Angela, Wallis, Christopher J. D., and Satkunasivam, Raj

Published
2024
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7. SENTINEL-1: A FEASIBILITY STUDY OF FLUORESCENCE ENHANCED PELVIC LYMPH NODE DETECTION USING INTRAVESICAL HEXAMINOLEVULINATE HCL DYE FOR PATIENTS WITH MUSCLE-INVASIVE BLADDER CANCER

Author

Huang, Emily, primary, Patel, Ashmi, additional, Riveros, Carlos, additional, Shen, Steven, additional, Hu, Chih-Chi Andrew, additional, Gupta, Nakul, additional, Melchiode, Zachary, additional, Hu, Siqi, additional, El-Zaatari, Ziad, additional, Satkunasivam, Raj, additional, Ranganathan, Sanjana, additional, Slawin, Jeremy, additional, and Lim, Kelvin, additional

Published
2024
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8. Morbidity and mortality of multivisceral resection with radical nephrectomy for locally advanced renal cell carcinoma: An analysis of the National Surgical Quality Improvement Program (NSQIP) database

Author

Lim, Kelvin, Riveros, Carlos, Ranganathan, Sanjana, Xu, Jiaqiong, Patel, Ashmi, Slawin, Jeremy, Ordonez, Adriana, Aghazadeh, Monty, Morgan, Monica, Miles, Brian J., Esnaola, Nestor, Klaassen, Zachary, Allenson, Kelvin, Brooks, Michael, Wallis, Christopher J.D., and Satkunasivam, Raj

Published
2023
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9. Comparative real-world survival outcomes of metastatic papillary and clear cell renal cell carcinoma treated with immunotherapy, targeted therapy, and combination therapy

Author

Riveros, Carlos, Ranganathan, Sanjana, Xu, Jiaqiong, Chang, Courtney, Kaushik, Dharam, Morgan, Monica, Miles, Brian J., Muhammad, Taliah, Anis, Maryam, Aghazadeh, Monty, Zhang, Jun, Efstathiou, Eleni, Klaassen, Zachary, Brooks, Michael A., Rini, Brian, Wallis, Christopher J.D., and Satkunasivam, Raj

Published
2023
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10. Surgeon Sex and Health Care Costs for Patients Undergoing Common Surgical Procedures

Author

Wallis, Christopher J. D., primary, Jerath, Angela, additional, Aminoltejari, Khatereh, additional, Kaneshwaran, Kirusanthy, additional, Salles, Arghavan, additional, Buntin, Melinda Beeuwkes, additional, Coburn, Natalie G., additional, Wright, Frances C., additional, Gotlib Conn, Lesley, additional, Heybati, Kiyan, additional, Luckenbaugh, Amy N., additional, Ranganathan, Sanjana, additional, Riveros, Carlos, additional, McCartney, Colin, additional, Armstrong, Kathleen A., additional, Bass, Barbara L., additional, Detsky, Allan S., additional, and Satkunasivam, Raj, additional

Published
2023
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11. Postoperative Discharge Destination Impacts 30-Day Outcomes: A National Surgical Quality Improvement Program Multi-Specialty Surgical Cohort Analysis

Author

Riveros, Carlos, primary, Ranganathan, Sanjana, additional, Shah, Yash B., additional, Huang, Emily, additional, Xu, Jiaqiong, additional, Geng, Michael, additional, Melchiode, Zachary, additional, Hu, Siqi, additional, Miles, Brian J., additional, Esnaola, Nestor, additional, Kaushik, Dharam, additional, Jerath, Angela, additional, Wallis, Christopher J. D., additional, and Satkunasivam, Raj, additional

Published
2023
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12. Comparative real-world survival outcomes of muscle-invasive bladder cancer treated with bladder-only vs. whole-pelvis concurrent chemoradiation

Author

Riveros, Carlos, primary, Ranganathan, Sanjana, additional, Haque, Waqar, additional, Huang, Emily, additional, Xu, Jiaqiong, additional, Kulkarni, Girish S., additional, Geng, Michael, additional, Anis, Maryam, additional, Muhammad, Taliah, additional, Chan, Keith, additional, Farach, Andrew, additional, Teh, Bin S., additional, Miles, Brian J., additional, Klaassen, Zachary, additional, Sonpavde, Guru P., additional, Wallis, Christopher, additional, and Satkunasivam, Raj, additional

Published
2023
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13. Surgeon Sex and Long-Term Postoperative Outcomes Among Patients Undergoing Common Surgeries

Author

Wallis, Christopher J. D., primary, Jerath, Angela, additional, Aminoltejari, Khatereh, additional, Kaneshwaran, Kirusanthy, additional, Salles, Arghavan, additional, Coburn, Natalie, additional, Wright, Frances C., additional, Gotlib Conn, Lesley, additional, Klaassen, Zachary, additional, Luckenbaugh, Amy N., additional, Ranganathan, Sanjana, additional, Riveros, Carlos, additional, McCartney, Colin, additional, Armstrong, Kathleen, additional, Bass, Barbara, additional, Detsky, Allan S., additional, and Satkunasivam, Raj, additional

Published
2023
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14. Comparative real-world survival outcomes of muscle-invasive bladder cancer treated with bladder-only vs. whole-pelvis concurrent chemoradiation.

Author

Riveros, Carlos, Ranganathan, Sanjana, Haque, Waqar, Huang, Emily, Jiaqiong Xu, Kulkarni, Girish S., Geng, Michael, Anis, Maryam, Muhammad, Taliah, Chan, Keith Syson, Farach, Andrew, Teh, Bin S., Miles, Brian J., Klaassen, Zachary, Sonpavde, Guru P., Wallis, Christopher J. D., and Satkunasivam, Raj

Subjects
*CONFIDENCE intervals, *OPERATIVE surgery, *TRANSURETHRAL resection of bladder, *ANTINEOPLASTIC agents, *REGRESSION analysis, *RETROSPECTIVE studies, *ACQUISITION of data, *CHEMORADIOTHERAPY, *TREATMENT effectiveness, *COMPARATIVE studies, *KAPLAN-Meier estimator, *DESCRIPTIVE statistics, *MEDICAL records, *OVERALL survival, *PROPORTIONAL hazards models, *EVALUATION, BLADDER tumors
Abstract

INTRODUCTION: Elective pelvic nodal irradiation for patients with muscle-invasive bladder cancer (MIBC) undergoing trimodal therapy (TMT) is controversial. In patients with node-negative (N0) MIBC, the benefit of elective whole-pelvis concurrent chemoradiation (WP-CCR) compared to bladder-only (BO)-CCR has not been demonstrated. Using realworld data from the National Cancer Database (NCDB), we sought to compare the overall survival (OS) between BO-CCR and WP-CCR for MIBC. METHODS: Using the 2020 NCDB Participant User File, we identified cases of MIBC diagnosed between 2017 and 2019. We selected patients with clinical T2-T4aN0M0 disease receiving CCR as first-line treatment. CCR was defined as transurethral resection of bladder tumor followed by =40 Gy radiation to the bladder with concurrent single- or multiple-agent chemotherapy. Based on elective nodal irradiation status, patients were stratified as having received BO-CCR vs. WP-CCR. OS analysis was performed using summary three-month conditional landmark, inverse probability treatment weighting (IPTW)-adjusted Kaplan-Meier estimates, and Cox regression. RESULTS: A total of 604 patients receiving CCR for MIBC were identified: 367 (60.8%) BO-CCR and 237 (39.2%) WP-CCR. Before IPTW, the groups were imbalanced in terms of baseline characteristics. The median followup of the weighted population was 42.3 months (interquartile range 18.1-49.1 months). In IPTW-adjusted Cox proportional hazards regression analysis, WP-CCR was associated with a significant OS benefit compared to BO-CCR (adjusted hazard ratio 0.72, 95% confidence interval 0.54-0.96, p=0.026). CONCLUSIONS: In the setting of CCR for N0 MIBC, this retrospective NCDB analysis revealed that WP-CCR was associated with a benefit in OS compared to BO-CCR. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Surgeon Sex and Health Care Costs for Patients Undergoing Common Surgical Procedures.

Author

Wallis, Christopher J. D., Jerath, Angela, Aminoltejari, Khatereh, Kaneshwaran, Kirusanthy, Salles, Arghavan, Buntin, Melinda Beeuwkes, Coburn, Natalie G., Wright, Frances C., Gotlib Conn, Lesley, Heybati, Kiyan, Luckenbaugh, Amy N., Ranganathan, Sanjana, Riveros, Carlos, McCartney, Colin, Armstrong, Kathleen A., Bass, Barbara L., Detsky, Allan S., and Satkunasivam, Raj

Published
2024
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16. Glomerular hyperfiltration is an independent predictor of postoperative outcomes: A NSQIPmulti‐specialty surgical cohort analysis

Author

Riveros, Carlos, primary, Ranganathan, Sanjana, additional, Huang, Emily, additional, Ordonez, Adriana, additional, Xu, Jiaqiong, additional, Geng, Michael, additional, Miles, Brian J., additional, Esnaola, Nestor, additional, Klaassen, Zachary, additional, Jerath, Angela, additional, Kim, S. Joseph, additional, Wallis, Christopher J. D., additional, and Satkunasivam, Raj, additional

Published
2023
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18. MP28-14 REAL-WORLD SURVIVAL OUTCOMES ASSOCIATED WITH IMMUNOTHERAPY, TARGETED THERAPY, AND COMBINATION THERAPY FOR METASTATIC PAPILLARY RENAL CELL CARCINOMA

Author

Riveros, Carlos, primary, Ranganathan, Sanjana, additional, Xu, Jiaqiong, additional, Huang, Emily, additional, Chang, Courtney, additional, Geng, Michael, additional, Kaushik, Dharam, additional, morgan, Monica, additional, muhammad, taliah, additional, anis, maryam, additional, aghazadeh, monty, additional, zhang, jun, additional, efstathiou, eleni, additional, Klaassen, Zachary, additional, Brooks, Michael A., additional, Brian, Rini, additional, Wallis, Christopher J.D., additional, and Satkunasivam, Raj, additional

Published
2023
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21. Chemotherapy, immunotherapy, or combination first-line treatment for metastatic urothelial carcinoma of the bladder: A large real-world experience.

Author

Ranganathan, Sanjana, primary, Riveros, Carlos, additional, Xu, Jiaqiong, additional, Geng, Michael, additional, Huang, Emily, additional, Anis, Maryam, additional, Muhammad, Taliah, additional, Zhang, Jun, additional, Efstathiou, Eleni, additional, Wallis, Christopher J.D., additional, Sonpavde, Guru P., additional, and Satkunasivam, Raj, additional

Published
2023
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24. The Association between Serum Albumin and Post-Operative Outcomes among Patients Undergoing Common Surgical Procedures: An Analysis of a Multi-Specialty Surgical Cohort from the National Surgical Quality Improvement Program (NSQIP)

Author

Nipper, Cole A., primary, Lim, Kelvin, additional, Riveros, Carlos, additional, Hsu, Enshuo, additional, Ranganathan, Sanjana, additional, Xu, Jiaqiong, additional, Brooks, Michael, additional, Esnaola, Nestor, additional, Klaassen, Zachary, additional, Jerath, Angela, additional, Arrington, Amanda, additional, Wallis, Christopher J. D., additional, and Satkunasivam, Raj, additional

Published
2022
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25. Glomerular hyperfiltration is an independent predictor of postoperative outcomes: A NSQIP multi‐specialty surgical cohort analysis.

Author

Riveros, Carlos, Ranganathan, Sanjana, Huang, Emily, Ordonez, Adriana, Xu, Jiaqiong, Geng, Michael, Miles, Brian J., Esnaola, Nestor, Klaassen, Zachary, Jerath, Angela, Kim, S. Joseph, Wallis, Christopher J. D., and Satkunasivam, Raj

Subjects
*TREATMENT effectiveness, *COHORT analysis, *GLOMERULAR filtration rate, *CHRONIC kidney failure, *DEMOGRAPHIC characteristics
Abstract

Aim: While high estimated glomerular filtration rate (eGFR) has been associated with increased overall mortality, its effect on postoperative outcomes is relatively understudied. We sought to investigate the association between high eGFR and 30‐day postoperative outcomes using a multi‐specialty surgical cohort. Methods: Using the National Surgical Quality Improvement Program database, we selected adult for whom eGFR could be calculated using the 2021 Chronic Kidney Disease Epidemiology Collaboration equation. Based on sex‐specific distributions of eGFR stratified by age quintiles, we classified patients into low (<5th percentile), normal (5–95th percentile) and high eGFR (>95th percentile). The primary outcome was a composite of any 30‐day major adverse outcomes, including: death, reoperation, cardiac arrest, myocardial infarction and stroke. Secondary outcomes included 30‐day infectious complications, venous thromboembolism (VTE), bleeding requiring transfusion, prolonged length of stay and unplanned readmission. After matching for demographic differences, comorbidity burden and operative characteristics, logistic regression models were used to evaluate the association between extremes of eGFR and the outcomes of interest. Results: Of 1 668 447 patients, 84 115 (5.07%) had a high eGFR. High eGFR was not associated with major adverse outcomes (odds ratio [OR] 1.00 [95% confidence interval (CI): 0.97, 1.03]); however, it was associated with reoperation (OR 1.04 [95% CI: 1.00,1.08]), infectious complications (OR 1.14 [95% CI: 1.11, 1.16]), VTE (OR 1.15 [95% CI: 1.09, 1.22]) and prolonged length of stay (OR 1.19 [95% CI: 1.16, 1.21]). Conclusion: Our findings support an association between high eGFR and adverse 30‐day postoperative outcomes. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Open vs. robot-assisted radical cystectomy with extracorporeal or intracorporeal urinary diversion for bladder cancer: A pairwise meta-analysis of outcomes and a network meta-analysis of complications

Author

Riveros, Carlos, Ranganathan, Sanjana, Nipper, Cole, Lim, Kelvin, Brooks, Michael, Dursun, Furkan, Miles, Brian J., Goh, Alvin C., Desai, Mihir, Klaassen, Zachary, Kulkarni, Girish S., Wallis, Christopher J.D., and Satkunasivam, Raj

Subjects
Original Research
Abstract

INTRODUCTION: There are no meta-analyses of randomized controlled trials (RCTs) comparing open radical cystectomy (OR C) with robot-assisted radical cystectomy (RARC), inclusive of both intracorporeal (iRARC) and extracorporeal (hybrid RARC, hRARC) urinary reconstruction. METHODS: MEDL INE, Embase, Scopus, the International Clinical Trials Registry Platform and ClinicalTrials.gov registries were searched in May 2022. Outcomes of interest included recurrence- or progression-free survival (RFS/PFS), margin status and lymph node yield, mean estimated blood loss (EBL) and operating room time (ORT ), hospital length of stay (LOS ), 90-day complications and readmissions, and quality of life (QoL). Pairwise meta-analyses and network meta-analyses were performed using random-effects models and Bayesian hierarchical random-effects models, respectively. RESULTS: We found no significant differences between RARC and OR C for oncological and most perioperative outcomes: RFS/PFS (hazard ratio [HR ] 0.91, 95% confidence interval [CI] 0.67–1.23); positive surgical margins (odds ratio [OR ] 1.05, 95% CI 0.60–1.85); lymph node yield (mean difference [MD ] −0.63, 95% CI −2.63–1.37); LOS (MD −0.22, 95% CI −1.10–0.65); overall complications (OR 0.81, 95% CI 0.61–1.07); major complications (OR 0.94, 95% CI 0.69–1.30); readmissions (OR 0.90, 95% CI 0.60–1.35); and QoL (standardized MD −0.02, 95% CI −0.17–0.14). We found significantly lower EBL for RARC compared to OR C (MD −312.61, 95% CI −447 to −178.22) at the expense of significantly prolonged ORT (MD 82.34 minutes, 95% CI 44.82–119.86). Network meta-analysis did not find significant differences in complications between hRARC and iRARC. CONCLUSIONS: This meta-analysis confirms the equivalence of RARC and OR C with respect to oncological outcomes.

Published
2022

27. Open vs. robot-assisted radical cystectomy with extracorporeal or intracorporeal urinary diversion for bladder cancer: A pairwise meta-analysis of outcomes and a network meta-analysis of complications by urinary diversion approach

Author

Riveros, Carlos, primary, Ranganathan, Sanjana, additional, Nipper, Cole, additional, Lim, Kelvin, additional, Brooks, Michael, additional, Dursun, Furkan, additional, Miles, Brian J., additional, Goh, Alvin C., additional, Desai, Mihir, additional, Klaasen, Zachary, additional, Kulkarni, Girish S., additional, Wallis, Christopher J.D., additional, and Satkunasivam, Raj, additional

Published
2022
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29. Quality of life outcomes following definitive radiation treatment for muscle invasive bladder cancer: a scoping review

Author

Ranganathan, Sanjana, Satkunasivam, Raj, and Riveros, Carlos

Subjects
Oncology, Urology, Medical Specialties, Medicine and Health Sciences
Abstract

Bladder cancer is diagnosed in approximately 81,180 patients annually, making the bladder one of the leading sites of new cancer diagnoses. The vast majority of these bladder cancers are urothelial carcinoma; at the time of diagnosis, approximately 25% of these cancers are muscle invasive or metastatic. The standard of care for these cancers is cystectomy, involving removal of the entire bladder, or trimodal therapy for select patients. Trimodal therapy includes resection of the bladder tumor, chemotherapy, and radiation therapy to the entire bladder. The objective of this scoping review is to understand the extent and type of evidence in regards to the quality of life effects of bladder radiation as a component of treatment for muscle invasive bladder cancer.

Published
2022
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30. Open vs. robot-assisted radical cystectomy with extracorporeal or intracorporeal urinary diversion for bladder cancer: A pairwise meta-analysis of outcomes and a network meta-analysis of complications by urinary diversion approach.

Author

Riveros, Carlos, Ranganathan, Sanjana, Nipper, Cole, Lim, Kelvin, Brooks, Michael, Dursun, Furkan, Miles, Brian J., Goh, Alvin C., Desai, Mihir, Klaassen, Zachary, Kulkarni, Girish S., Wallis, Christopher J. D., and Satkunasivam, Raj

Subjects
*HEMORRHAGE risk factors, *CYSTECTOMY, *LENGTH of stay in hospitals, *META-analysis, *MEDICAL information storage & retrieval systems, *SURGICAL robots, *URINARY diversion, *SYSTEMATIC reviews, *CANCER relapse, *LYMPH nodes, *PATIENT readmissions, *QUALITY of life, *MEDLINE, *PROGRESSION-free survival, *DISEASE risk factors, SURGICAL complication risk factors, BLADDER tumors
Abstract

Introduction: There are no meta-analyses of randomized controlled trials (RCTs) comparing open radical cystectomy (ORC) with robot-assisted radical cystectomy (RARC), inclusive of both intracorporeal (iRARC) and extracorporeal (hybrid RARC, hRARC) urinary reconstruction. Methods: MEDLINE, Embase, Scopus, the International Clinical Trials Registry Platform and ClinicalTrials.gov registries were searched in May 2022. Outcomes of interest included recurrence-or progression-free survival (RFS/PFS), margin status and lymph node yield, mean estimated blood loss (EBL) and operating room time (ORT), hospital length of stay (LOS), 90-day complications and readmissions, and quality of life (QoL). Pairwise meta-analyses and network meta-analyses were performed using random-effects models and Bayesian hierarchical random-effects models, respectively. Results: We found no significant differences between RARC and ORC for oncological and most perioperative outcomes: RFS/PFS (hazard ratio [HR] 0.91, 95% confidence interval [CI] 0.67-1.23); positive surgical margins (odds ratio [OR] 1.05, 95% CI 0.60-1.85); lymph node yield (mean difference [MD] -0.63, 95% CI -2.63-1.37); LOS (MD -0.22, 95% CI -1.10-0.65); overall complications (OR 0.81, 95% CI 0.61-1.07); major complications (OR 0.94, 95% CI 0.69-1.30); readmissions (OR 0.90, 95% CI 0.60-1.35); and QoL (standardized MD -0.02, 95% CI -0.17-0.14). We found significantly lower EBL for RARC compared to ORC (MD -312.61, 95% CI - 447 to -178.22) at the expense of significantly prolonged ORT (MD 82.34 minutes, 95% CI 44.82-119.86). Network meta-analysis did not find significant differences in complications between hRARC and iRARC. Conclusions: This meta-analysis confirms the equivalence of RARC and ORC with respect to oncological outcomes. [ABSTRACT FROM AUTHOR]

Published
2023
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