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1. Retinitis Pigmentosa and Therapeutic Approaches: A Systematic Review.

Author

Confalonieri, Filippo, La Rosa, Antonio, Ottonelli, Giovanni, Barone, Gianmaria, Ferraro, Vanessa, Di Maria, Alessandra, Romano, Mary, Randazzo, Alessandro, Vallejo-Garcia, Josè Luis, Vinciguerra, Paolo, and Petrovski, Goran

Subjects
RETINAL degeneration, RETINITIS pigmentosa, EVIDENCE gaps, VISION, VISION disorders
Abstract

Background: Retinitis pigmentosa (RP) is a group of hereditary retinal dystrophies characterized by progressive degeneration of photoreceptor cells, which results in debilitating visual impairment. This systematic review aims to evaluate the efficacy and safety of emerging treatment modalities for RP, including gene therapy, mesenchymal-cell-based approaches, and supplementary interventions. Methods: A comprehensive search of electronic databases was conducted to identify relevant studies published up to February 2024. Studies reporting outcomes of treatment interventions for RP, including randomized controlled trials, non-randomized studies, and case series, were included. Data extraction and synthesis were performed according to predefined criteria, focusing on assessing the quality of evidence and summarizing key findings. Results: The search yielded 13 studies meeting inclusion criteria, encompassing diverse treatment modalities and study designs. Gene therapy emerged as a promising therapeutic approach, with several studies reporting favorable outcomes regarding visual function preservation and disease stabilization. Mesenchymal-cell-based therapies also demonstrated potential benefits, although evidence remains limited and heterogeneous. Supplementary interventions, including nutritional supplements and neuroprotective agents, exhibited variable efficacy, with conflicting findings across studies. Conclusions: Despite the lack of definitive curative treatments, emerging therapeutic modalities promise to slow disease progression and preserve visual function in individuals with RP. However, substantial gaps in evidence and heterogeneity in study methodologies underscore the need for further research to elucidate optimal treatment strategies, refine patient selection criteria, and enhance long-term outcomes. This systematic review provides a comprehensive synthesis of current evidence and highlights directions for future research to advance the care and management of individuals with RP. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Outcomes in the Treatment of Subretinal Macular Hemorrhage Secondary to Age-Related Macular Degeneration: A Systematic Review

Author

Confalonieri, Filippo, primary, Ferraro, Vanessa, additional, Barone, Gianmaria, additional, Di Maria, Alessandra, additional, Petrovski, Beáta Éva, additional, Vallejo Garcia, Josè Luis, additional, Randazzo, Alessandro, additional, Vinciguerra, Paolo, additional, Lumi, Xhevat, additional, and Petrovski, Goran, additional

Published
2024
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4. Outcomes of Abrupt Switch to Bevacizumab of Patients Undergoing Aflibercept Intravitreal Injections for Neovascular Age-Related Macular Degeneration in a Tertiary Center in Lombardy, Italy: A Real-Life Retrospective Analysis

Author

Randazzo, Alessandro, primary, Raimondi, Raffaele, additional, Fossati, Giovanni, additional, Romano, Mary, additional, Sorrentino, Tania, additional, Castellani, Carlo, additional, Rossi, Costanza, additional, Cancian, Giuseppe, additional, and Vinciguerra, Paolo, additional

Published
2021
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5. Mobile Edge Computing: Architetture ed Analisi della Live Migration

Author

Randazzo, Alessandro, TINNIRELLO, Ilenia, and BUSACCA, Alessandro

Subjects
Pre-Copy, MLP network, Docker, Virtual Machine, Kata-Container, working set size, MEC, Live Migration, Container
Abstract

Con l'ormai prossima rete mobile 5G entreranno a far parte della nostra quotidianità nuovi servizi applicativi, mai prima possibili, grazie all'avvicinamento di risorse di calcolo e di memoria nei pressi dell'utente in mobilità. Un’architettura abilitante i futuri servizi è quella di Mobile Edge Computing (MEC) in cui cloud di capacità inferiori rispetto a quelli presenti nella core della rete sono dislocati nei pressi della stazioni radio e metteranno a disposizione risorse di calcolo tali da permettere, tramite la tecnica di offloading, la fruizione di servizi quali realtà aumentata, gaming online, contenuti streaming ad alta risoluzione ed operazioni di data analytics. Ogni nuovo paradigma porta con sé nuove sfide d'affrontare e risolvere per potere essere applicabile. Ecco, dunque, che s'introduce l'obiettivo perseguito durante questo percorso di ricerca che è stato quello di analizzare, modellare diversi aspetti di uno dei tanti problemi del MEC che è la continuità del servizio che è in funzione non solo del normale spostamento dell'utente mobile, ma anche dalle risorse presenti del server sorgente. Il percorso di studi e di ricerca è stato così strutturato: Studio iniziale sulle nuove sfide del 5G per poi dedicarsi ad uno studio approfondito sull'architettura di riferimento del mobile edge computing sino ad una piattaforma open-source di nome M-CORD. Questa prima parte è stata propedeutica per potere svolgere i seguenti lavori di ricerca. Un primo lavoro è consistito nel proporre una modifica di un framework per la live migration ed analizzare i tempi di migrazione di applicazioni RAM-intensive sviluppando un modello simulante l’esecuzione di tali applicazioni con uno dei possibili algoritmi di migrazione e cioè quello di pre-copy anzichè quello di post-copy. Le nostre ipotesi confortate dai risultati numerici hanno evidenziato che l'algoritmo di pre-copy è preferibile nella service migration di applicazioni RAM-intensive. Un successivo lavoro è nato dalla considerazione che grazie ai server MEC vi sarà un'altissima diffusione di contenuti multimediali e molti di essi saranno a pagamento e regolati da contratti di service level agreement (SLA) e, dunque, abbiamo progettato e sviluppato un'applicazione di machine learning che potrebbe essere installata direttamente nello smartphone che in background analizza ed individua in tempo reale la risoluzione video ricevuta così da verificare il rispetto del SLA. Inoltre abbiamo anche disegnato un'architettura in cui la service migration possa essere originata dal client mobile, una volta verificatosi la violazione (breach) contrattuale. I risultati sono stati promettenti visto che si è ottenuta un'accuratezza superiore al 95% su dati mai visti. Questo lavoro ha anche evidenziato le enormi potenzialità offerte dal machine learning capace di discernere caratteristiche intrinseche dell'applicazione senza alcun ausilio di analisi protocollare. Un terzo lavoro è stato quello di estendere il modello di analisi dei tempi di migrazione per applicazioni RAM-intensive andando a simulare, sempre sotto l'ipotesi di applicare l'algoritmo di pre-copy, la presenza di un controller SDN che permette una continua riconfigurazione dinamica dei percorsi di rete. A tale scopo abbiamo quindi proposto una nuova architettura basata sia su MEC che SDN, modellato e simulato alcuni scenari di traffico di rete ed analizzato le prestazioni temporali. I risultati hanno evidenziato che grazie alla continua riconfigurazione dinamica dei percorsi, assicurando quello più veloce ad ogni iterazione dell'algoritmo, in determinati scenari si sono ottenuti tempi di migrazioni più bassi sino al 90%. È, dunque, chiaro che la cooperazione di MEC e SDN possa fornire un servizio di migrazione più efficiente poiché ad un minore tempo di trasferimento permetterà il rispetto dei stringenti vincoli temporali di molte applicazioni. Infine, un quarto lavoro è nato dall'osservazione che se è vero che la tecnologia più in linea per abilitare i nuovi servizi 5G sia quella dei containers, essendo molto più veloci delle virtual machine, è altrettanto vero che ad oggi per design i containers sono soggetti ad intrinsechi problemi di sicurezza dovuto principalmente alla condivisione del Kernel host con tutti i containers in esecuzione. Per tale motivo, anziché sviluppare soluzioni personalizzate non standardizzate che facessero uso sia dei containers che delle virtual machine, abbiamo ricercato ed analizzato una nuova promettente architettura che potrebbe costituire la base per la migrazione dei servizi garantendo al contempo sia leggerezza e velocità che sicurezza di nome Kata-containers. Essendo una nuovissima architettura abbiamo svolto uno studio sulle sue principali caratteristiche e li abbiamo poi confrontate da un punto di vista qualitativo con quelle di Docker che rappresenta lo standard de facto per la tecnologia containers. Da tale analisi è emerso che tale nuova architettura, se pur ancora da migliorare, potrà rappresentare il pilastro portante per la migrazione dei servizi tra MEC server.

Published
2020

7. List of Contributors

Author

Abad, Juan-Carlos, primary, Abelson, Mark B, additional, Abramson, David H, additional, Acquadro, Martin A, additional, Adamis, Anthony P, additional, Adams, Wesley H, additional, Afshari, Natalie A, additional, Ai, Everett, additional, Aiello, Lloyd M, additional, Aiello, Lloyd P, additional, Akduman, Levent, additional, Albano, Marissa L, additional, Albert, Daniel M., additional, Alexandrou, Terry J, additional, Alfonso, Eduardo C, additional, Alié, Jorge L, additional, Alizadeh, Hassan, additional, Al Jadaan, Ibrahim A, additional, Al-Jastaneiah, Sabah, additional, Allen, Calliope E, additional, Allen, David, additional, Allen, Robert C, additional, Alm, Albert, additional, Al-Swailem, Samar, additional, Alt, Abigail K, additional, Altaweel, Michael M, additional, Anderson, Russell, additional, Andreoli, Christopher M, additional, Androudi, Sofia, additional, Ang, Leonard PK, additional, Anzaar, Fahd, additional, Apple, David J, additional, Arrigg, Claudia A, additional, Artal, Pablo, additional, Asbell, Penny, additional, Asdourian, George K, additional, Atebara, Neal, additional, Atmaca-Sonmez, Pelin, additional, Audo, Isabelle, additional, Auffarth, Gerd U, additional, Avery, Robin K, additional, Azar, Dimitri T, additional, Baker, Ann S, additional, Balles, Mark, additional, Barnes, Scott D, additional, Barnett, Donald M, additional, Barney, Neal P, additional, Barouch, Fina C, additional, Bartley, George B, additional, Barton, Jason JS, additional, Behlau, Irmgard, additional, Belda, Jose I, additional, Bennett, Jeffrey L, additional, Bennett, Timothy J, additional, Berdy, Gregg J, additional, Bernardino, Carlo Roberto, additional, Bernardino, Vitaliano, additional, Berson, Eliot L, additional, Bharadwaj, Amitabh, additional, Bhisitkul, Robert, additional, Bhui, Ravinder D, additional, Bilyk, Jurij, additional, Biousse, Valérie, additional, Bird, Alan C, additional, Blair, Norman Paul, additional, Blodi, Barbara A, additional, Blumenkranz, Mark S, additional, Boldt, H Culver, additional, Borchert, Mark S, additional, Borrillo, Luigi, additional, Borodic, Gary E, additional, Boruchoff, S Arthur, additional, Bose, Swaraj, additional, Boulton, Michael E, additional, Bowman, RW, additional, Bradley, Elizabeth A, additional, Brazitikos, Periklis D, additional, Breeze, Robert, additional, Bressler, Neil M, additional, Bressler, Susan B, additional, Brini, Alfred, additional, Budenz, Donald L, additional, Buffenn, Angela N, additional, Burk, Scott E, additional, Butrus, Salim, additional, Callanan, David, additional, Cameron, J Douglas, additional, Cantor, Louis B, additional, Cantore, William A, additional, Cantu-Dibildox, Jorge, additional, Casas, Victoria, additional, Casper, Miriam, additional, Casten, Robin J, additional, Catoira, Yara P, additional, Cavallerano, Jerry, additional, Chai, Samantha J, additional, Chalita, Maria R, additional, Chamberlain, Sherman M, additional, Chan, Audrey S, additional, Chan, Chi-Chao, additional, Chan, Paul, additional, Chapin, Matthew J, additional, Chapman, Karen L, additional, Chen, Eric, additional, Chen, Joe, additional, Chen, Julie A, additional, Chen, Teresa C, additional, Chen, Zhou, additional, Chévez-Barrios, Patricia, additional, Chew, Emily Y, additional, Chiang, Mark, additional, Chodosh, James, additional, Chong, Eva-Marie, additional, Chun, Denise, additional, Chylack, Leo T, additional, Ciardella, Antonio P, additional, Civan, Mortimer, additional, Clamen, Liane, additional, Clark, John I, additional, Cockerham, Glenn, additional, Cohen, Andre, additional, Cohen, Elisabeth J, additional, Colby, Kathryn A, additional, Coleman, Anne L, additional, Coleman, Hanna R, additional, Colin, Joseph, additional, Collier, J Michael, additional, Comer, Grant M, additional, Conlon, M Ronan, additional, Cooper, Kim E, additional, Corbett, James J, additional, Coma, Miguel C, additional, Cyrlin, Marshall N, additional, Dagi, Linda R, additional, Dahlgren, Matthew A, additional, Daley, Timothy J, additional, Da Mata, Andrea P, additional, Damato, Bertil, additional, D'Amico, Donald J, additional, Dana, Reza, additional, Danan-Husson, Aude, additional, Danesh-Meyer, Helen B, additional, Danis, Ronald P, additional, Darlington, Jason K, additional, Davidson, Stefanie L, additional, Davis, Janet L, additional, Davis, Elizabeth A, additional, de la Cruz, Jose J, additional, de la Garza, Adam G, additional, DeAngelis, Margaret M, additional, DeMartelaere, Sheri L, additional, Demer, Joseph L, additional, Dhaliwal, Avninder, additional, Dieckert, J Paul, additional, Do, Diana V, additional, Doane, Marshall G, additional, Dodds, Christopher, additional, Dohlman, Claes H, additional, Donati, Guy, additional, Donnenfeld, Eric D, additional, Drack, Arlene, additional, Dryja, Thaddeus P, additional, Dueker, David, additional, Duker, Jay S, additional, Dunbar, Jennifer A, additional, Dunn, James P, additional, Dupps, William J, additional, Durand, Marlene L, additional, Dutton, Jonathan J, additional, Eandi, Chiara M, additional, Edward, Deepak P, additional, Egan, Robert A, additional, Eichenbaum, David A, additional, Eklund, Susan E, additional, Engle, Elizabeth C, additional, Erickson, Kristine, additional, Esmaeli, Bita, additional, Fay, Aaron, additional, Feiner, Leonard, additional, Fekrat, Sharon, additional, Ferris, Frederick L, additional, Fine, Howard F, additional, Fletcher, Donald C, additional, Flikier, Paul, additional, Floyd, Richard P, additional, Flynn, Harry W, additional, Fong, Donald S, additional, Font, Ramon L, additional, Forbes, Brian JR, additional, Foroozan, Rod, additional, Foster, Bradley S, additional, Foster, C Stephen, additional, Foster, Jill A, additional, Foulks, Gary N, additional, Fountain, Tamara R, additional, Fox, Gregory M, additional, Freddo, Thomas F, additional, Freedman, Sharon F, additional, Freund, K Bailey, additional, Friberg, Thomas R, additional, Friedman, Alan H, additional, Friedman, David, additional, Friedman, Deborah I, additional, Friedman, Ephraim, additional, Fu, Arthur D, additional, Fulton, Anne B, additional, Galal, Ahmed, additional, Galetta, Steven, additional, Gallardo, Mark, additional, Gallie, Brenda, additional, Garner, Alec, additional, Garrity, James A, additional, Gatinel, Damien, additional, Gedde, Steven J, additional, Geist, Craig E, additional, Gerber, Steve, additional, Ghanem, Ramon C, additional, Gieser, Jon P, additional, Gilmore, Michael S, additional, Gimbel, Howard V, additional, Gipson, Ilene K, additional, Glover, Tyrone, additional, Goldberg, Robert A, additional, Goldenfeld, Mordechai, additional, Goldstein, Scott M, additional, Gomi, Cintia F, additional, Gong, Haiyan, additional, Gonzales, John A, additional, Goosey, John, additional, Gottlieb, Justin L, additional, Gould, Joshua, additional, Gragoudas, Evangelos S, additional, Granet, David B, additional, Greaney, Michael J, additional, Green, Daniel G, additional, Grehn, Franz, additional, Greiner, Jack V, additional, Greven, Craig M, additional, Griepentrog, Gregory J, additional, Groenewald, Carl, additional, Grosskreutz, Cynthia L, additional, Grover, Lori Latowski, additional, Gullapalli, Vamsi K, additional, Gulur, Padma, additional, Gunther, Jonathan, additional, Gupta, Manish, additional, Gupta, Mayank, additional, Guyer, David R, additional, Haivala, Darin R, additional, Haller, Julia A, additional, Halmagyi, GM, additional, Halperin, Lawrence S, additional, Hamdi, Islam M, additional, Hamilton, Steven R, additional, Hammersmith, Kristin M, additional, Han, Dennis P, additional, Hansen, Ronald M, additional, Harbour, J William, additional, Hariprasad, Seenu M, additional, Harissi-Dagher, Mona, additional, Hassan, Shirin E., additional, Hatton, Mark P, additional, Hawley, Pamela, additional, Hayashida, Yasutaka, additional, Heckenlively, John R, additional, Hedges, Thomas R, additional, Heggie, Alfred D, additional, Heher, Katrinka L, additional, Heier, Jeffrey S, additional, Hejtmancik, J Fielding, additional, Henderson, Bonnie A, additional, Hersh, Peter S, additional, Hidayat, Ahmed A, additional, Higginbotham, Eva Juliet, additional, Hirose, Tatsuo, additional, Ho, Allen C, additional, Ho, ThucAnh T, additional, Hogan, R Nick, additional, Holck, David E, additional, Holekamp, Nancy M, additional, Hovland, Peter G, additional, Hsu, Thomas C, additional, Hsu, William C, additional, Huang, Andrew JW, additional, Hughes, Mark S, additional, Hui, Jennifer, additional, Hunter, David G, additional, Huryn, Laryssa A, additional, Husain, Deeba, additional, Hyndiuk, Robert A, additional, Ip, Michael, additional, Jacobs, Brian J, additional, Jakobiec, Frederick A, additional, Jampol, Lee M, additional, Jensen, Harold G, additional, Ji, Fei, additional, Johnson, David L, additional, Johnson, Douglas H, additional, Johnson, Mark W, additional, Johnson, R Paul, additional, Johnson, Robert N, additional, Joos, Karen M, additional, Joyce, Nancy C, additional, Jumper, J Michael, additional, Jurkunas, Ula V., additional, Kahana, Alon, additional, Kahook, Malik Y, additional, Kanner, Elliott, additional, Kalwerisky, Kevin, additional, Kaplan, Henry J, additional, Karatza, Ekaterini C, additional, Kardon, Randy, additional, Katowitz, James A, additional, Katowitz, William R, additional, Kazlas, Melanie, additional, Keefe, Kelly S, additional, Kelley, Lara, additional, Kent, Charles J, additional, Kenyon, Kenneth R, additional, Khan, Bilal F, additional, Khan, Jemshed A, additional, Khan, Naheed W, additional, Khaw, Peng Tee, additional, Kherani, Femida, additional, Kim, Eva C, additional, Kim, Hee Joon, additional, Kim, Ivana K, additional, Kim, Jonathan W, additional, Kim, Rosa Y, additional, Kim, Stella K, additional, Kim, Tae-Im, additional, Klais, Christina M, additional, Klapper, Stephen R, additional, Klein, Barbara EK, additional, Kleinmann, Guy, additional, Klink, Thomas, additional, Klisovic, Dino D, additional, Klyce, Stephen D, additional, Kocaturk, Tolga, additional, Kohnen, Thomas, additional, Kojima, Takeshi, additional, Koller, Tobias, additional, Kostick, David A, additional, Kraut, Joel A, additional, Krishnan, Chandrasekharan, additional, Krueger, Ronald R, additional, Krug, Joseph H, additional, Krupsky, Sara, additional, Kuchtey, Rachel W, additional, Kurban, Ramsay S, additional, Kurz, Paul A, additional, Kuszak, JR, additional, Kwon, Young H, additional, Labbe, Thad A, additional, Lam, Deborah L, additional, Lamkin, Jeffrey C, additional, Lamping, Kathleen A, additional, Lane, Anne Marie, additional, Lane, Katherine A, additional, Lane, Keith J, additional, Lass, Jonathan H, additional, Lawrence, Mary G, additional, Lee, Andrew G, additional, Lee, Carol M, additional, Lee, Michael S, additional, Lee, Paul P, additional, Lee, William B, additional, Leibovitch, Igal, additional, Lemke, Bradley N, additional, Lemley, Craig A, additional, Leonardi, Andrea, additional, Lessell, Simmons, additional, Levin, Leonard A, additional, Levy-Clarke, Grace A, additional, Lew, Julie C, additional, Lewis, Craig, additional, Li, Wei, additional, Lim, Laurence S, additional, Lim, Lyndell L, additional, Lim, Wee-Kiak, additional, Liu, Grant T, additional, Loewenstein, John I, additional, Lott, McGregor N, additional, Lowry, Jonathan C, additional, Lyon, David B, additional, Lytle, Robert E, additional, MacCumber, Mathew, additional, Mackool, Bonnie T, additional, Madiwale, Nalini A, additional, Mah, Francis, additional, Mainster, Martin A, additional, Manning, Michael H, additional, Mansberger, Steven L, additional, Marc, Robert E, additional, Marchong, Mellone, additional, Marcus, Dennis M, additional, Mares, Julie A, additional, Marr, Brian P, additional, Martinez, Carlos E, additional, Massof, Robert W, additional, Matsumoto, Yukihiro, additional, Mattox, Cynthia, additional, Maus, Marlon, additional, McCabe, Cathleen M, additional, McCormick, Steven A, additional, McCrakken, Michael, additional, McCulley, James P, additional, McDermott, John A, additional, McDonald, H Richard, additional, McDonald, Marguerite B, additional, McDonnell, Peter J, additional, McGillivray, Robert, additional, McKeown, Craig A, additional, McLaughlin, James, additional, McMullen, W Wynn, additional, Melamed, Shlomo, additional, Meligonis, George, additional, Mendrinos, Efstratios, additional, Meyer, Dale R, additional, Meyerle, Catherine B, additional, Mieler, William F, additional, Migliori, Michael, additional, Mihm, Martin C, additional, Miller, Darlene, additional, Miller, David, additional, Miller, Joan W, additional, Miller, Neil R, additional, Mills, David M, additional, Mills, Monte D, additional, Milman, Tatyana, additional, Mogk, Lylas, additional, Mogk, Marja, additional, Monés, Jordi, additional, Montes-Micó, Robert, additional, Morse, Christie L, additional, Morton, Asa D, additional, Moskowitz, Anne, additional, Mukai, Shizuo, additional, Murphree, A Linn, additional, Murphy, Robert P, additional, Murray, Timothy G, additional, Murray, Philip I, additional, Nagao, Karina, additional, Neitz, Jay, additional, Neitz, Maureen, additional, Netland, Peter A, additional, Neufeld, Arthur H, additional, Newman, Nancy J, additional, Ng, Eugene WM, additional, Nguyen, Quan Dong, additional, Niederkorn, Jerry Y, additional, Noecker, Robert J, additional, Nussenblatt, Robert B, additional, O'Brien, Joan M, additional, O'Brien, Paul D, additional, O'Brien, Terrence P, additional, O'Day, Denis, additional, Olk, R Joseph, additional, Olsen, Karl R, additional, Onal, Sumru, additional, Ooi, Yen Hoong, additional, Opremcak, E Mitchel, additional, Ousler, George, additional, Ozment, Randall R, additional, Packer, Samuel, additional, Palmer, Millicent L, additional, Papaliodis, George N, additional, Park, DJ John, additional, Parke, David W, additional, Parsa, Cameron F, additional, Parsons, M Andrew, additional, Pasquale, Louis R, additional, Patel, Neha N, additional, Patel, Sayjal J, additional, Patrianakos, Thomas D, additional, Patrinely, James R, additional, Pavan-Langston, Deborah, additional, Peli, Eli, additional, Pepin, Susan M, additional, Perez, Victor L, additional, Pérez-Santonja, Juan J, additional, Perfect, John R, additional, Perry, Henry D, additional, Piatigorsky, Joram, additional, Pieramici, Dante, additional, Pierce, Eric A, additional, Pineda, Roberto, additional, Pless, Misha L, additional, Pomeranz, Howard D, additional, Pournaras, Constantin J, additional, Power, William, additional, Prakash, Manvi, additional, Prasad, Anita G, additional, Purvin, Valerie, additional, Quillen, David A, additional, Quinn, Graham E, additional, Rabena, Melvin D, additional, Rae, James L, additional, Raizman, Michael B, additional, Randazzo, Alessandro, additional, Rao, Narsing A, additional, Rapuano, Christopher J, additional, Reeves, Sherman W, additional, Regillo, Carl D, additional, Reichel, Elias, additional, Reinke, Martin H, additional, Rhee, Douglas, additional, Richter, Claudia U, additional, Rizzo, Joseph F, additional, Robb, Richard M, additional, Roden, Anja C, additional, Rodgers, I Rand, additional, Rodrigues, Merlyn M, additional, Ron, Yonina, additional, Rose, Geoffrey E, additional, Rosen, Emanuel S, additional, Rosenbaum, James T, additional, Rosenthal, Perry, additional, Rouse, Strutha C, additional, Rovner, Barry W, additional, Rozanowska, Malgorzata, additional, Rubin, Michael P, additional, Rubin, Peter AD, additional, Rumelt, Shimon, additional, Rustgi, Anil K, additional, Rutar, Tina, additional, Ruttum, Mark S, additional, Rutzen, Allan R, additional, Ryan, Edward T, additional, Sadun, Alfredo A, additional, Sahel, José-Alain, additional, Saligan, Leorey, additional, Salim, Sarwat, additional, Salmon, John F, additional, Salomão, Diva R, additional, Sami, David, additional, Sandberg, Michael A, additional, Sangwan, Virender S, additional, Saornil, Maria A, additional, Sassani, Joseph W, additional, Sayegh, Rony R, additional, Schachat, Andrew P, additional, Schell, Wiley A, additional, Schefler, Amy C, additional, Scheufele, Tina, additional, Schiedler, Vivian, additional, Schneider, Gretchen, additional, Schroeder, Alison, additional, Schuchard, Ronald A, additional, Schuman, Joel S, additional, Schwab, Ivan R, additional, Scott, Adrienne, additional, Scott, Ingrid U, additional, Sears, Marvin L, additional, Seddon, Johanna M, additional, Seiler, Theo, additional, Selkin, Robert P, additional, Semba, Richard D, additional, Serbanescu, Irina, additional, Sexton, Briar, additional, Shaarawy, Tarek M, additional, Shah, Peter, additional, Shapiro, Aron, additional, Sharma, Savitri, additional, Shein, Jean, additional, Shetlar, Debra J, additional, Shields, M Bruce, additional, Shields, Carol L, additional, Shields, Jerry A, additional, Shingleton, Bradford J, additional, Shore, John W, additional, Shuba, Lesya M, additional, Simon, Guy J Ben, additional, Simmons, Richard J, additional, Simpson, Michael, additional, Singh, Arun D, additional, Singh, Omah S, additional, Sisley, Karen, additional, Sit, Arthur J, additional, Smerdon, David, additional, Smiddy, William E, additional, Smith, Ronald E, additional, Smith, Terry J, additional, Snebold, Neal G, additional, Sobrin, Lucia, additional, Sorenson, John A, additional, Soukiasian, Sarkis H, additional, Spaeth, George L, additional, Spaide, Richard F, additional, Srivastava, Monika, additional, Srivastava, Sunil K, additional, Stangos, Alexandros N, additional, Starck, Tomy, additional, Stark, Walter J, additional, Stein, Joshua D, additional, Steinert, Roger F, additional, Strauss, Leon, additional, Streeten, Barbara W, additional, Streilein, J Wayne, additional, Strong, James D, additional, Sugino, Ilene K, additional, Suhler, Eric B, additional, Sullivan, Timothy J, additional, Sun, Jennifer K, additional, Sunness, Janet S, additional, Sutula, Francis C, additional, Syed, Nasreen A, additional, Ta, Christopher N, additional, Takei, Hidehiro, additional, Talamo, Jonathan H, additional, Tamesis, Richard R, additional, Tamhankar, Madhura, additional, Tarbet, Kristen J, additional, Tarver-Carr, Michelle, additional, Terry, Mark A, additional, Thomas, Joseph M, additional, Thompson, Vance, additional, Thorne, Jennifer E, additional, Thurtell, Matthew J, additional, Tingey, David P, additional, To, King W, additional, Tobaigy, Faisal M, additional, Tolentino, Michael J, additional, Tong, Melissa G, additional, Torkildsen, Gail, additional, Toth, Cynthia A, additional, Traboulsi, Elias I, additional, Trucksis, Michele, additional, Tsai, James C, additional, Tsai, Julie H, additional, Tse, David T, additional, Tseng, Scheffer CG, additional, Tu, Elmer Y, additional, Udell, Ira J, additional, Valenzuela, Alejandra A, additional, Van Gelder, Russell N, additional, Van Stavern, Gregory P, additional, Vander Veen, Deborah K, additional, Vavvas, Demetrios, additional, Verity, David H, additional, Vinciguerra, Paolo, additional, Vinger, Paul F, additional, Volpe, Nicholas J, additional, Wackernagel, Werner, additional, Wadhwa, Sonal Desai, additional, Wagoner, Michael D, additional, Waheed, Nadia K, additional, Walton, David S, additional, Wand, Martin, additional, Wang, Jie Jin, additional, Warden, Scott M, additional, Webb, Lennox, additional, Weber, David, additional, Wee, Daniel, additional, Westerfeld, Corey B, additional, Westfall, Christopher T, additional, Whitcup, Scott M, additional, White, Valerie A, additional, White, William L, additional, Wickens, Jason, additional, Wiggs, Janey L, additional, Wilensky, Jacob T, additional, Wilkinson, Charles P, additional, Williams, Patrick D, additional, Wilson, David J, additional, Wilson, M Roy, additional, Wilson, Steven E, additional, Winokur, Jules, additional, Wirostko, William J, additional, Wollstein, Gadi, additional, Wong, Albert Chak Ming, additional, Wong, Tien Y, additional, Woog, John J, additional, Wride, Michael, additional, Wu, Carolyn S, additional, WuDunn, Darrell, additional, Yang, Jean, additional, Yannuzzi, Lawrence A, additional, Yaremchuk, Michael J, additional, Yeatts, R Patrick, additional, Yee, Richard W, additional, Yeh, Steven, additional, Young, Lucy HY, additional, Yu, Jenny Y, additional, Yue, Beatrice YJT, additional, Zacks, Charles M, additional, Zagelbaum, Bruce M, additional, Zamani, Maryam, additional, Zarbin, Marco, additional, Zografos, Leonidas, additional, and Zoumalan, Christopher I, additional

Published
2008
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15. Propuesta de estandarización de los procesos y procedimientos en el área de nutrición del Zoológico de Cali

Author

Recalde Randazzo, Alessandro, Rodríguez Pérez, Lina Marcela, Torres Quintero, Sory Carola, and Asesor Tesis

Subjects
Procesos y procedimientos, Zoológico de Cali, Manejo de materiales, Trabajos de grado, Producción intelectual registrada - Universidad Icesi, Abastecimiento de alimentos, Ingeniería Industrial
Abstract

La Fundación Zoológico de Cali, cuenta con diferentes áreas, dentro de las cuáles se encuentra el área de nutrición. Ésta es una de las más importantes, dado que su función principal consiste en brindarles a los animales pertenecientes a los diferentes centros de operación, como lo son el CAFS (Centro de Atención a la Fauna Silvestre), Clínica, Rotación y Parque; una alimentación balanceada que les permita adquirir las energías necesarias para sobrevivir y desarrollarse. La estandarización de los procesos y procedimientos, se ha convertido en una de las herramientas más poderosas de los Ingenieros Industriales en la actualidad, ya que permite obtener una gran ventaja competitiva en las organizaciones. En un mundo tan cambiante como el actual, en el cual muchas variables están en fuego, se hace necesaria la creación de estándares que permitan fortalecer las habilidades del personal, diseñar procesos productivos y generar grandes progresos en pro de un mejor desempeño del sistema. Como uno de los primeros pasos del Kaizen (mejoramiento continuo), la estandarización se puede considerar el punto de partida para implementar mejoras en cada uno de los puestos de trabajo y en el área a nivel general.

Published
2012

16. Pneumatic tools for vitreoretinal surgery

Author

Romano,Mario R, Vallejo-Garcia,Jose Luis, Randazzo,Alessandro, Vinciguerra,Paolo, Romano,Mario R, Vallejo-Garcia,Jose Luis, Randazzo,Alessandro, and Vinciguerra,Paolo

Abstract

Mario R Romano, Jose Luis Vallejo-Garcia, Alessandro Randazzo, Paolo VinciguerraIstituto Clinico Humanitas, Via Manzoni 56, 20089 Rozzano, Milan, ItalyAbstract: One of the difficulties of microsurgery is learning how to control physiological tremors. The pneumatic tool eliminates the physiological tremor, but no tactile feedback is provided. The manual tremor when closing the forceps is completely eliminated and the exact target can be more easily grabbed. Forceps closure pressure can rise up to 50 psi, whereas the scissors can be used in two modes: multicut and proportional. When performing bimanual surgery the pedal range is divided into two steps: in the first step, the forceps are controlled, and in the second step, the forceps remain closed. At the same time the scissors start to work in the preselected mode. No adverse events occurred and no iatrogenic retinal breaks were produced. Precision and control sensation were a grateful surprise.Keywords: pneumatic forceps, pneumatic scissors, physiological tremor

Published
2012

20. Pneumatic tools for vitreoretinal surgery.

Author

Romano, Mario R., Vallejo-Garcia, Jose Luis, Randazzo, Alessandro, and Vinciguerra, Paolo

Subjects
PROLIFERATIVE vitreoretinopathy, RETINAL surgery, OPHTHALMIC surgery, RETINAL diseases, EYE infections
Abstract

One of the difficulties of microsurgery is learning how to control physiological tremors. The pneumatic tool eliminates the physiological tremor, but no tactile feedback is provided. The manual tremor when closing the forceps is completely eliminated and the exact target can be more easily grabbed. Forceps closure pressure can rise up to 50 psi, whereas the scissors can be used in two modes: multicut and proportional. When performing bimanual surgery the pedal range is divided into two steps: in the first step, the forceps are controlled, and in the second step, the forceps remain closed. At the same time the scissors start to work in the preselected mode. No adverse events occurred and no iatrogenic retinal breaks were produced. Precision and control sensation were a grateful surprise. [ABSTRACT FROM AUTHOR]

Published
2012
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21. Outcomes of Abrupt Switch to Bevacizumab of Patients Undergoing Aflibercept Intravitreal Injections for Neovascular Age-Related Macular Degeneration in a Tertiary Center in Lombardy, Italy: A Real-Life Retrospective Analysis

Author

Tania Sorrentino, Alessandro Randazzo, Raffaele Raimondi, Giovanni Fossati, Costanza Rossi, Mary Romano, Giuseppe Cancian, Paolo Vinciguerra, Carlo Castellani, Randazzo, Alessandro, Raimondi, Raffaele, Fossati, Giovanni, Romano, Mary, Sorrentino, Tania, Castellani, Carlo, Rossi, Costanza, Cancian, Giuseppe, and Vinciguerra, Paolo

Subjects
medicine.medical_specialty, Article Subject, genetic structures, Bevacizumab, business.industry, RE1-994, Macular degeneration, medicine.disease, eye diseases, Ophthalmology, Chart review, Age related, medicine, Retrospective analysis, In patient, Statistical analysis, sense organs, business, Research Article, medicine.drug, Aflibercept
Abstract

Purpose. To assess real-life anatomical and functional outcomes of switch to bevacizumab in patients undergoing aflibercept intravitreal injections for nAMD. Methods. Retrospective chart review of all patients diagnosed with nAMD and undergoing intravitreal injections of aflibercept who switched to bevacizumab after the resolution XI/1986 of Lombardy Region. Results. Among 128 patients undergoing intravitreal injections, a total of 29 eyes of 29 patients met all inclusion criteria and were included in the statistical analysis. Best corrected visual acuity and central macular thickness did not change significantly ( p > 0.05 ) between baseline, after the loading phase, and at the last follow-up. Conclusion. Switching to bevacizumab has been safe and efficacious in patients responding to the loading phase. According to our results, the restrictions imposed by Lombardy Region did not cause any harm to patients undergoing intravitreal anti-VEGF injections.

Published
2021

23. Kata Containers: An Emerging Architecture for Enabling MEC Services in Fast and Secure Way

Author

Alessandro Randazzo, Ilenia Tinnirello, Randazzo Alessandro, and Tinnirello Ilenia

Subjects
Service (systems architecture), Settore ING-INF/03 - Telecomunicazioni, Interface (Java), Computer science, 020206 networking & telecommunications, 02 engineering and technology, computer.software_genre, Virtualization, Architecture, Internet of things, Optimization, Virtual machine, Software deployment, Virtual machine, 020204 information systems, Server, Container (abstract data type), 0202 electrical engineering, electronic engineering, information engineering, Operating system, Architecture, computer, Live migration
Abstract

New coming applications will be only possible through Mobile Edge Servers deployed in proximity of the mobile users. Due to the user's mobility and server's workload, service migration will be an integral part of the services. For this reason, a standardized architecture should be designed to accomplish a workload migration in a secure and timely manner. Most research done to date has focused on the use of either virtual machine (VM) or container or a mix of both recently. A final solution might be an architecture only having the advantages of both technologies as the security of the VM and the speed of the containers. Custom solutions, actually, by using both technologies, need continuous optimization from case to case and not least, any solution is not standards-compliant. To this purpose, we present a novel architecture, Kata Containers, that is stewarded by the OpenStack Foundation (OSF), which supports industry standards including OCI container format, Kubernetes CRI interface, as well as legacy virtualization technologies. With this work, we highlight its state of the art and the motivations that may make it the right candidate for deployment of new MEC services. Additionally, we make a qualitative analysis against the most used runtime container, Docker runc, to show what features should be still improved or developed from scratch by future research.

Published
2019

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