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1. Spatial analysis of Hofbauer cell transcriptome, distribution and morphology in placentas exposed to Plasmodium falciparum

Author

Ataide, Ricardo, primary, Harding, Rebecca, additional, Dharmaratne, Malindrie, additional, Chen, Yunshun, additional, Fielding, Katherine, additional, Whitehead, Lachlan, additional, Rogers, Kelly, additional, Anttila, Casey, additional, Ling, Ling, additional, Hickey, Peter, additional, Amann-Zalcenstein, Daniela, additional, Moya, Ernest, additional, Mhango, Gomezghani, additional, Kamiza, Steve, additional, Randall, Louise, additional, Bennett, Cavan, additional, Mzembe, Glory, additional, Mwangi, Martin N., additional, Braat, Sabine, additional, Phiri, Kamija, additional, and Pasricha, Sant-Rayn, additional

Published
2023
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2. Protocol and statistical analysis plan for a randomized controlled trial of the effect of intravenous iron on anemia in Malawian pregnant women in their third trimester (REVAMP – TT)

Author

Harding, Rebecca, primary, Moya, Ernest, additional, Ataíde, Ricardo, additional, Truwah, Zinenani, additional, Mzembe, Glory, additional, Mhango, Gomezgani, additional, Demir, Ayşe V., additional, Stones, William, additional, Randall, Louise, additional, Seal, Marc, additional, Johnson, Katherine, additional, Bode, Stefan, additional, Mwangi, Martin N., additional, Pasricha, Sant-Rayn, additional, Braat, Sabine, additional, and Phiri, Kamija S., additional

Published
2023
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7. Age-Related Susceptibility to Severe Malaria Associated with Galectin-2 in Highland Papuans

Author

Randall, Louise M., Kenangalem, Enny, Lampah, Daniel A., Tjitra, Emiliana, Mwaikambo, Esther D., Handojo, Tjandra, Piera, Kim A., Zhao, Zhen Zhen, de Labastida Rivera, Fabian, Zhou, Yonghong, McSweeney, Karli M, Le, Lien, Amante, Fiona H., Haque, Ashraful, Stanley, Amanda C., Woodberry, Tonia, Salwati, Ervi, Granger, Donald L., Hobbs, Maurine R., Price, Ric N., Weinberg, J. Brice, Montgomery, Grant W., Anstey, Nicholas M., and Engwerda, Christian R.

Published
2010

8. Soluble lymphotoxin is an important effector molecule in GVHD and GVL

Author

Markey, Kate A., Burman, Angela C., Banovic, Tatjana, Kuns, Rachel D., Raffelt, Neil C., Rowe, Vanessa, Olver, Stuart D., Don, Alistair L.J., Morris, Edward S., Pettit, Allison R., Wilson, Yana A., Robb, Renee J., Randall, Louise M., Korner, Heinrich, Engwerda, Christian R., Clouston, Andrew D., MacDonald, Kelli P.A., and Hill, Geoffrey R.

Published
2010
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13. A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland papuan children and adults

Author

Granger Donald L, Salwati Ervi, Woodberry Tonia, Stanley Amanda C, Haque Ashraful, Amante Fiona H, Le Lien, McSweeney Karli M, Zhou Yonghong, de Labastida Rivera Fabian, Zhao Zhen Z, Piera Kim A, Handojo Tjandra, Mwaikambo Esther D, Tjitra Emiliana, Lampah Daniel A, Kenangalem Enny, Randall Louise M, Hobbs Maurine R, Price Ric N, Weinberg J Brice, Montgomery Grant W, Anstey Nicholas M, and Engwerda Christian R

Subjects
Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Severe malaria (SM) syndromes caused by Plasmodium falciparum infection result in major morbidity and mortality each year. However, only a fraction of P. falciparum infections develop into SM, implicating host genetic factors as important determinants of disease outcome. Previous studies indicate that tumour necrosis factor (TNF) and lymphotoxin alpha (LTα) may be important for the development of cerebral malaria (CM) and other SM syndromes. Methods An extensive analysis was conducted of single nucleotide polymorphisms (SNPs) in the TNF, LTA and LTB genes in highland Papuan children and adults, a population historically unexposed to malaria that has migrated to a malaria endemic region. Generated P-values for SNPs spanning the LTA/TNF/LTB locus were corrected for multiple testing of all the SNPs and haplotype blocks within the region tested through 10,000 permutations. A global P-value of < 0.05 was considered statistically significant. Results No associations between SNPs in the TNF/LTA/LTB locus and susceptibility to SM in highland Papuan children and adults were found. Conclusions These results support the notion that unique selective pressure on the TNF/LTA/LTB locus in different populations has influenced the contribution of the gene products from this region to SM susceptibility.

Published
2010
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15. STAT1 Signaling in Astrocytes Is Essential for Control of Infection in the Central Nervous System

Author

Hidano, Shinya, primary, Randall, Louise M., additional, Dawson, Lucas, additional, Dietrich, Hans K., additional, Konradt, Christoph, additional, Klover, Peter J., additional, John, Beena, additional, Harris, Tajie H., additional, Fang, Qun, additional, Turek, Bradley, additional, Kobayashi, Takashi, additional, Hennighausen, Lothar, additional, Beiting, Daniel P., additional, Koshy, Anita A., additional, and Hunter, Christopher A., additional

Published
2016
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16. Evaluation of national guidelines for bronchiolitis: AGREEments and controversies.

Author

Cavaye, Diana, Roberts, Daniel P, Saravanos, Gemma L, Hsu, Zhen Y, Miyajima, Risa, Randall, Louise E, Salmon, Eliot DD, Tan, Yi Le, Tucker, Jean A, Yeoh, Seng K, and Britton, Philip N

Subjects
GUIDELINES, BRONCHIOLITIS, RESPIRATORY syncytial virus, PHYSICIAN practice patterns, EVIDENCE-based medicine
Abstract

Aim: Bronchiolitis is a common respiratory illness and is a leading cause of hospitalisation in infancy. We aimed to appraise three recent national bronchiolitis guidelines produced by the Australasian Paediatric Research in Emergency Departments International Collaborative, the National Institute for Health and Care Excellence in the UK and the American Academy of Pediatrics.Methods: A group of final-year medical students and one senior clinician used the AGREE II tool to appraise each guideline in two stages. First, two students appraised each guideline independently and presented their results. Second, two self-selected students met with the senior clinicians to review all scores to ensure completeness of the appraisal and consistency of AGREE II application.Results: The guidelines scored well overall, with particular strengths in the domains of clarity of presentation, scope and purpose and rigour of development. Comparison of the recommendations across each guideline demonstrated a high degree of consistency. Notable differences included recommendations for the role of palivizumab in prevention of bronchiolitis, the use of continuous pulse oximetry monitoring in the hospitalised patient and the value of respiratory virus testing.Conclusions: Our appraisal of bronchiolitis guidelines from three high-income countries demonstrated that they were of high quality, with substantial areas of agreement. Most aspects of clinical practice should be uniform for this common paediatric condition. Areas of guideline weakness were in the domains of applicability and editorial independence. We identified three areas of controversy where further research is needed to support stronger evidence-based recommendations. [ABSTRACT FROM AUTHOR]

Published
2019
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17. Hepcidin and Erythroferrone Levels across Human Pregnancy, and the Effect of IV Iron Infusion - a Revamp Substudy

Author

Fielding, Katherine, Mwangi, Martin, Moya, Ernest, Ataide, Ricardo, Mzembe, Glory, Randall, Louise, Braat, Sabine, Harding, Rebecca, Phiri, Kamija S., and Pasricha, Sant-Rayn

Abstract

Hepcidin is known to be suppressed in human pregnancy; and while it's known that intravenous iron infusion increases hepcidin levels, it is unknown to what degree this occurs during pregnancy.

Published
2023
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18. The aryl hydrocarbon receptor promotes IL-10 production by natural killer cells

Author

Wagage, Sagie, John, Beena, Krock, Bryan L., Hall, Aisling O'Hara, Randall, Louise M., Karp, Christopher L., Simon, M. Celeste, and Hunter, Christopher A.

Subjects
Inflammation, Mice, Knockout, Aryl Hydrocarbon Receptor Nuclear Translocator, Lymphocyte Activation, Interleukin-12, Article, Interleukin-10, Mice, Inbred C57BL, Interferon-gamma, Mice, Toxoplasmosis, Animal, Receptors, Aryl Hydrocarbon, Genes, Reporter, Mice, Inbred CBA, Animals, Lectins, C-Type, Receptors, Immunologic, Killer Cells, Lymphokine-Activated, T-Box Domain Proteins, Dimerization, Toxoplasma, Signal Transduction
Abstract

The cytokine IL-10 has an important role in limiting inflammation in many settings, including toxoplasmosis. In the present studies, an IL-10 reporter mouse was used to identify the sources of this cytokine following challenge with Toxoplasma gondii. During infection, multiple cell types expressed the IL-10 reporter but NK cells were a major early source of this cytokine. These IL-10 reporter(+) NK cells expressed high levels of the IL-12 target genes T-bet, KLRG1, and IFN-γ, and IL-12 depletion abrogated reporter expression. However, IL-12 signaling alone was not sufficient to promote NK cell IL-10, and activation of the aryl hydrocarbon receptor (AHR) was also required for maximal IL-10 production. NK cells basally expressed the AHR, relevant chaperone proteins, and the AHR nuclear translocator, which heterodimerizes with the AHR to form a competent transcription factor. In vitro studies revealed that IL-12 stimulation increased NK cell AHR levels, and the AHR and AHR nuclear translocator were required for optimal production of IL-10. Additionally, NK cells isolated from T. gondii-infected Ahr(-/-) mice had impaired expression of IL-10, which was associated with increased resistance to this infection. Taken together, these data identify the AHR as a critical cofactor involved in NK cell production of IL-10.

Published
2014

23. Age-Related susceptibility to severe Malaria associated with Galectin-2 in Highland Papuans

Author

Randall, Louise, Kenangalem, Enny, Lampah, Daniel, Tjitra, Emiliana, Mwaikambo, Esther, Handojo, Tjandra, Piera, Kim Alison, Zhao, Zhen Zhen, Rivera, Fabian de Labastida, Zhou, Yonghong, McSweeney, Karli, Le, Lien, Amante, Fiona, Haque, Ashraful, Stanley, Amanda, Woodberry, Tonia, Salwati, Ervi, Granger, Donald, Hobbs, Maurine, Price, Ric, Weinberg, J Brice, Montgomery, Grant, Anstey, Nicholas, Engwerda, Christian, Randall, Louise, Kenangalem, Enny, Lampah, Daniel, Tjitra, Emiliana, Mwaikambo, Esther, Handojo, Tjandra, Piera, Kim Alison, Zhao, Zhen Zhen, Rivera, Fabian de Labastida, Zhou, Yonghong, McSweeney, Karli, Le, Lien, Amante, Fiona, Haque, Ashraful, Stanley, Amanda, Woodberry, Tonia, Salwati, Ervi, Granger, Donald, Hobbs, Maurine, Price, Ric, Weinberg, J Brice, Montgomery, Grant, Anstey, Nicholas, and Engwerda, Christian

Published
2010

24. A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland papuan children and adults

Author

Randall, Louise M., Kenangalem, Enny, Lampah, Daniel A., Tjitra, Emiliana, Mwaikambo, Esther D., Handojo, Tjandra, Piera, Kim A., Zhao, Zhen Z., Labastida Rivera, Fabian de, Zhou, Yonghong, McSweeney, Karli M., Le, Lien, Amante, Fiona H., Haque, Ashraful, Stanley, Amanda C., Woodberry, Tonia, Salwati, Ervi, Granger, Donald L., Price, Ric N., Anstey, Nicholas M., et al., Randall, Louise M., Kenangalem, Enny, Lampah, Daniel A., Tjitra, Emiliana, Mwaikambo, Esther D., Handojo, Tjandra, Piera, Kim A., Zhao, Zhen Z., Labastida Rivera, Fabian de, Zhou, Yonghong, McSweeney, Karli M., Le, Lien, Amante, Fiona H., Haque, Ashraful, Stanley, Amanda C., Woodberry, Tonia, Salwati, Ervi, Granger, Donald L., Price, Ric N., Anstey, Nicholas M., and et al.

Abstract

Background: Severe malaria (SM) syndromes caused by Plasmodium falciparum infection result in major morbidity and mortality each year. However, only a fraction of P. falciparum infections develop into SM, implicating host genetic factors as important determinants of disease outcome. Previous studies indicate that tumour necrosisfactor (TNF) and lymphotoxin alpha (LTa) may be important for the development of cerebral malaria (CM) and other SM syndromes.Methods: An extensive analysis was conducted of single nucleotide polymorphisms (SNPs) in the TNF, LTA and LTB genes in highland Papuan children and adults, a population historically unexposed to malaria that has migrated to a malaria endemic region. Generated P-values for SNPs spanning the LTA/TNF/LTB locus were corrected for multiple testing of all the SNPs and haplotype blocks within the region tested through 10,000 permutations. A global Pvalue of < 0.05 was considered statistically significant.Results: No associations between SNPs in the TNF/LTA/LTB locus and susceptibility to SM in highland Papuan children and adults were found.Conclusions: These results support the notion that unique selective pressure on the TNF/LTA/LTB locus in different populations has influenced the contribution of the gene products from this region to SM susceptibility.

Published
2010

25. Immune-mediated mechanisms of parasite tissue sequestration during experimental cerebral malaria

Author

Amante, Fiona H., Haque, Ashraful, Stanley, Amanda C., de Labastida Rivera, Fabian, Randall, Louise M., Wilson, Yana A., Yeo, Gladys, Pieper, Christian, Crabb, Brendan S., de Koning-Ward, Tania F., Lundie, Rachel J., Good, Michael F., Pinzon-Charry, Alberto, Pearson, Mark S., Duke, Mary G., McManus, Donald P., Loukas, Alex, Hill, Geoff R., Engwerda, Christian R., Amante, Fiona H., Haque, Ashraful, Stanley, Amanda C., de Labastida Rivera, Fabian, Randall, Louise M., Wilson, Yana A., Yeo, Gladys, Pieper, Christian, Crabb, Brendan S., de Koning-Ward, Tania F., Lundie, Rachel J., Good, Michael F., Pinzon-Charry, Alberto, Pearson, Mark S., Duke, Mary G., McManus, Donald P., Loukas, Alex, Hill, Geoff R., and Engwerda, Christian R.

Abstract

Cerebral malaria is a severe complication of malaria. Sequestration of parasitized RBCs in brain microvasculature is associated with disease pathogenesis, but our understanding of this process is incomplete. In this study, we examined parasite tissue sequestration in an experimental model of cerebral malaria (ECM). We show that a rapid increase in parasite biomass is strongly associated with the induction of ECM, mediated by IFN-γ and lymphotoxin α, whereas TNF and IL-10 limit this process. Crucially, we discovered that host CD4+ and CD8+ T cells promote parasite accumulation in vital organs, including the brain. Modulation of CD4+ T cell responses by helminth coinfection amplified CD4+ T cell-mediated parasite sequestration, whereas vaccination could generate CD4+ T cells that reduced parasite biomass and prevented ECM. These findings provide novel insights into immune-mediated mechanisms of ECM pathogenesis and highlight the potential of T cells to both prevent and promote infectious diseases.

Published
2010

27. Critical Roles for LIGHT and Its Receptors in Generating T Cell-Mediated Immunity during Leishmania donovani Infection

Author

Stanley, Amanda C., primary, de Labastida Rivera, Fabian, additional, Haque, Ashraful, additional, Sheel, Meru, additional, Zhou, Yonghong, additional, Amante, Fiona H., additional, Bunn, Patrick T., additional, Randall, Louise M., additional, Pfeffer, Klaus, additional, Scheu, Stefanie, additional, Hickey, Michael J., additional, Saunders, Bernadette M., additional, Ware, Carl, additional, Hill, Geoff R., additional, Tamada, Koji, additional, Kaye, Paul M., additional, and Engwerda, Christian R., additional

Published
2011
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28. Analysis of Behavior and Trafficking of Dendritic Cells within the Brain during Toxoplasmic Encephalitis

Author

John, Beena, primary, Ricart, Brendon, additional, Tait Wojno, Elia D., additional, Harris, Tajie H., additional, Randall, Louise M., additional, Christian, David A., additional, Gregg, Beth, additional, De Almeida, Daniel Manzoni, additional, Weninger, Wolfgang, additional, Hammer, Daniel A., additional, and Hunter, Christopher A., additional

Published
2011
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30. A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland papuan children and adults

Author

Randall, Louise M, primary, Kenangalem, Enny, additional, Lampah, Daniel A, additional, Tjitra, Emiliana, additional, Mwaikambo, Esther D, additional, Handojo, Tjandra, additional, Piera, Kim A, additional, Zhao, Zhen Z, additional, de Labastida Rivera, Fabian, additional, Zhou, Yonghong, additional, McSweeney, Karli M, additional, Le, Lien, additional, Amante, Fiona H, additional, Haque, Ashraful, additional, Stanley, Amanda C, additional, Woodberry, Tonia, additional, Salwati, Ervi, additional, Granger, Donald L, additional, Hobbs, Maurine R, additional, Price, Ric N, additional, Weinberg, J Brice, additional, Montgomery, Grant W, additional, Anstey, Nicholas M, additional, and Engwerda, Christian R, additional

Published
2010
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31. Immune-Mediated Mechanisms of Parasite Tissue Sequestration during Experimental Cerebral Malaria

Author

Amante, Fiona H., primary, Haque, Ashraful, additional, Stanley, Amanda C., additional, Rivera, Fabian de Labastida, additional, Randall, Louise M., additional, Wilson, Yana A., additional, Yeo, Gladys, additional, Pieper, Christian, additional, Crabb, Brendan S., additional, de Koning-Ward, Tania F., additional, Lundie, Rachel J., additional, Good, Michael F., additional, Pinzon-Charry, Alberto, additional, Pearson, Mark S., additional, Duke, Mary G., additional, McManus, Donald P., additional, Loukas, Alex, additional, Hill, Geoff R., additional, and Engwerda, Christian R., additional

Published
2010
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32. Cutting Edge: Selective Blockade of LIGHT-Lymphotoxin β Receptor Signaling Protects Mice from Experimental Cerebral Malaria Caused by Plasmodium berghei ANKA

Author

Randall, Louise M., primary, Amante, Fiona H., additional, Zhou, Yonghong, additional, Stanley, Amanda C., additional, Haque, Ashraful, additional, Rivera, Fabian, additional, Pfeffer, Klaus, additional, Scheu, Stefanie, additional, Hill, Geoff R., additional, Tamada, Koji, additional, and Engwerda, Christian R., additional

Published
2008
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38. Pivotal Advance: Peritoneal cavity B‐1 B cells have phagocytic and microbicidal capacities and present phagocytosed antigen to CD4+T cells

Author

Parra, David, Rieger, Aja M., Li, Jun, Zhang, Yong‐An, Randall, Louise M., Hunter, Christopher A., Barreda, Daniel R., and Sunyer, J. Oriol

Abstract

Phagocytic capacity of peritoneal cavity B‐1 B cells and their ability to present antigen from phagocytosed particles to CD4+ T cells. Breaking the long‐held paradigm that primary B cells are not phagocytic, several studies have demonstrated recently that B cells from fish, amphibians, and reptilians have a significant phagocytic capacity. Whether such capacity has remained conserved in certain mammalian B cell subsets is presently an enigma. Here, we report a previously unrecognized ability of PerC B‐1a and B‐1b lymphocytes to phagocytose latex beads and bacteria. In contrast, B‐2 lymphocytes had an almost negligible ability to internalize these particles. Upon phagocytosis, B‐1a and B‐1b cells were able to mature their phagosomes into phagolysosomes and displayed the ability to kill internalized bacteria. Importantly, B‐1a and B‐1b cells effectively present antigen recovered from phagocytosed particles to CD4+T cells. However, these cells showed a much lower competence to present soluble antigen or antigen from large, noninternalized particles. B‐1 B cells presented particulate and soluble antigen to CD4+T cells more efficiently than macrophages, whereas DCs were the most potent APCs. The novel phagocytic and microbicidal abilities identified in B‐1 B lymphocytes strengthen the innate nature that has long been attributed to these cells. In the context of adaptive immunity, we show that these innate immune processes are relevant, as they enable B‐1 B cells to present phagocytosable particulate antigen. These capacities position these cells at the crossroads that link innate with adaptive immune processes. In a broader context, these newly identified capacities of B‐1 B cells further support the previously recognized functional, developmental, and evolutionary relationships between these cells and macrophages.

Published
2012
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39. Determination of inorganic tin, methyltin, and butyltin compounds in sediments

Author

Randall, Louise, Han, Jennie, and Weber, James

Abstract

A simple method is described for the determination of inorganic tin, methyl-, and butyltin compounds in sediments. Freeze-dried samples were extracted with a solution containing 2.5 M calcium chloride and 2.5 M hydrochloric acid. The extracts were analyzed by hydride generation-atomic absorption spectrometry. Recoveries from spiking experiments were greater than 70 ± 10% for most of the alkyltin compounds. Results from Great Bay Estuary (New Hampshire) sediment samples are presented.

Published
1986
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45. Cutting edge: selective blockade of LIGHT-lymphotoxin beta receptor signaling protects mice from experimental cerebral malaria caused by Plasmodium berghei ANKA.

Author

Randall LM, Amante FH, Zhou Y, Stanley AC, Haque A, Rivera F, Pfeffer K, Scheu S, Hill GR, Tamada K, and Engwerda CR

Subjects
Animals, Antigen Presentation genetics, Antigen Presentation immunology, Antigens, Protozoan immunology, Brain immunology, CD4-Positive T-Lymphocytes immunology, CD8-Positive T-Lymphocytes immunology, Cytokines genetics, Cytokines immunology, Killer Cells, Natural immunology, Lymphocyte Activation genetics, Lymphocyte Activation immunology, Lymphotoxin beta Receptor genetics, Malaria, Cerebral genetics, Mice, Mice, Knockout, Monocytes immunology, Signal Transduction genetics, Spleen immunology, Tumor Necrosis Factor Ligand Superfamily Member 14 genetics, Lymphotoxin beta Receptor immunology, Malaria, Cerebral immunology, Plasmodium berghei immunology, Signal Transduction immunology, Tumor Necrosis Factor Ligand Superfamily Member 14 immunology
Abstract

Studies in experimental cerebral malaria (ECM) in mice have identified T cells and TNF family members as critical mediators of pathology. In this study we report a role for LIGHT-lymphotoxin beta Receptor (LTbetaR) signaling in the development of ECM and control of parasite growth. Specific blockade of LIGHT-LTbetaR, but not LIGHT-herpesvirus entry mediator interactions, abrogated the accumulation of parasites and the recruitment of pathogenic CD8(+) T cells and monocytes to the brain during infection without affecting early activation of CD4(+) T cells, CD8(+) T cells, or NK cells. Importantly, blockade of LIGHT-LTbetaR signaling caused the expansion of splenic monocytes and an overall enhanced capacity to remove and process Ag during infection, as well as reduced systemic cytokine levels when control mice displayed severe ECM symptoms. In summary, we have discovered a novel pathogenic role for LIGHT and LTbetaR in ECM, identifying this TNF family receptor-ligand interaction as an important immune regulator during experimental malaria.

Published
2008
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