143 results on '"Rana DS"'
Search Results
2. Histoplasmosis masquerading as hemophagocytic lymphohistiocytosis in renal allograft recipient: a case report
- Author
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Tiwari, Vaibhav, primary, Kumar, Tarun, additional, Bhalla, Anil, additional, and Rana, DS, additional
- Published
- 2023
- Full Text
- View/download PDF
3. Benidipine for Hypertension in Chronic Kidney Disease with Cardiodiabetes
- Author
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Rana, DS, primary
- Published
- 2018
- Full Text
- View/download PDF
4. Outcomes of ABO–incompatible kidney transplantation with respect to baseline isoagglutinin immunoglobulin G titers
- Author
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Gaur, Lovy, additional, Bhalla, AnilKumar, additional, Shingada, Aakash, additional, Gupta, Ashwani, additional, Malik, Manish, additional, Gupta, Anurag, additional, Bhargava, Vinant, additional, Gupta, Pallav, additional, Joshi, Anant, additional, Ranjan, HarshJauhariVivek, additional, Khillan, Kamini, additional, and Rana, DS, additional
- Published
- 2022
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5. Conservation agriculture for sustainable intensification in South Asia
- Author
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Jat, ML, Jat, ML, Chakraborty, D, Ladha, JK, Rana, DS, Gathala, MK, McDonald, A, Gerard, B, Jat, ML, Jat, ML, Chakraborty, D, Ladha, JK, Rana, DS, Gathala, MK, McDonald, A, and Gerard, B
- Abstract
Agriculture’s contribution to the Sustainable Development Goals requires climate-smart and profitable farm innovations. In the past decade, attention has been given to conservation agriculture as a ‘sustainable intensification’ strategy, although a lack of evidence-based consensus on the merits of conservation agriculture prevails in the context of intensive smallholder farming in South Asia. A meta-analysis using 9,686 paired site–year comparisons representing different indicators of cropping-system performance suggest significant (P < 0.05) benefits when conservation-agriculture component practices are implemented either separately or in tandem. For example, zero tillage with residue retention had a mean yield advantage of 5.8%, a water use efficiency increase of 12.6%, an increase in net economic return of 25.9% and a reduction of 12–33% in global warming potential, with more-favourable responses on loamy soils and in maize–wheat systems. Results suggest that there are opportunities to maximize expected benefits, and policymakers and development practitioners should continue to be appraised of the potential of CA for contributing to the Sustainable Development Goals in South Asia.
- Published
- 2020
6. Hypervitaminosis D and acute interstitial nephritis: Tale of injections
- Author
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Tiwari, Vaibhav, primary, Arora, Veronica, additional, Rajput, Jitendra, additional, Gupta, Anurag, additional, Divyaveer, Smita, additional, Bijarnia-Mahay, Sunita, additional, Gupta, Pallav, additional, Bhargava, Vinant, additional, Malik, Manish, additional, Gupta, Ashwani, additional, Bhalla, AnilKumar, additional, and Rana, DS, additional
- Published
- 2021
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7. Granulomatosis with polyangiitis masquerading as renal mass: Case report and literature review
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Tiwari, Vaibhav, primary, Raman, Abhishek, additional, Gupta, Anurag, additional, Gupta, Pallav, additional, Joshi, Abhijeet, additional, Bhargava, Vinant, additional, Malik, Manish, additional, Gupta, Ashwani, additional, Bhalla, AnilKumar, additional, and Rana, DS, additional
- Published
- 2021
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8. Evaluation of factors influencing outcomes in pauci-immune crescentic glomerulonephritis: Single centre experience of 51 cases
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Gupta, Pallav, primary, Dharamdasani, Satyendra, additional, Gupta, Anurag, additional, Bhalla, AK, additional, Gupta, Ashwani, additional, Malik, Manish, additional, Bhargava, Vinant, additional, Tiwari, Vaibhav, additional, Rana, DS, additional, and Sapra, RL, additional
- Published
- 2021
- Full Text
- View/download PDF
9. COVID-19 in CKD patients: Report from India
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Tiwari, Vaibhav, primary, Pawar, Nikita, additional, Gupta, Anurag, additional, Bhargava, Vinant, additional, Malik, Manish, additional, Gupta, Ashwani, additional, Bhalla, AnilKumar, additional, and Rana, DS, additional
- Published
- 2021
- Full Text
- View/download PDF
10. Etiological spectrum of infective diarrhea in renal transplant patient by stool PCR: An Indian Perspective
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Tiwari, Vaibhav, primary, Anand, Yogeshman, additional, Gupta, Anurag, additional, Divyaveer, Smita, additional, Bhargava, Vinant, additional, Malik, Manish, additional, Gupta, Ashwani, additional, Bhalla, AnilKumar, additional, and Rana, DS, additional
- Published
- 2021
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- View/download PDF
11. Chylous ascites after laparoscopic donor nephrectomy: Case report
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Tiwari, Vaibhav, primary, Bhandari, Gaurav, additional, Gupta, Anurag, additional, Bhargava, Vinant, additional, Malik, Manish, additional, Gupta, Ashwani, additional, Bhalla, AnilKumar, additional, and Rana, DS, additional
- Published
- 2021
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12. Immunoadsorption column reuse
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Tiwari, Vaibhav, primary, Gupta, Anurag, additional, Divyaveer, Smita, additional, Bhargava, Vinant, additional, Malik, Manish, additional, Gupta, Ashwani, additional, Bhalla, AnilK, additional, and Rana, DS, additional
- Published
- 2021
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13. Effect of Pr-Ca substitution on the transport and magnetic behavior of LaMnO3 perovskite
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Thaker, CM, Rayaprol, S, Mavani, Krushna, Rana, DS, Sahasrabudhe, MS, Patil, SI, and Kuberkar, DG
- Published
- 2002
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14. Structural studies and T c dependence in La2−x Dy x Ca y Ba2Cu4+y O z type mixed oxide superconductors
- Author
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Rayaprol, S, Mavani, Krushna, Thaker, CM, Rana, DS, Chakravorty, Keka, Paranjape, SK, Ramanadham, M, Kulkarni, Nilesh A, and Kuberkar, DG
- Published
- 2002
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15. Chapter-29 Disturbances of Calcium and Phosphorus Metabolism and their Consequences in Chronic Kidney Disease
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Rana, DS, primary
- Published
- 2008
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16. Effect of De novo donor-specific antibodies on graft function in renal allograft recipients
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Singh, RaviKumar, primary, Gupta, Ashwani, additional, Bhargava, Vinant, additional, Gupta, Anurag, additional, Tiwari, Vaibhav, additional, Malik, Manish, additional, Bhalla, AK, additional, Rana, DS, additional, and Jain, Monika, additional
- Published
- 2020
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17. SP427TO STUDY THE EFFECT OF ARTERIAL PULSE ENHANCEMENT TECHNOLOGY (A-PET) THERAPY USING VASCUPUMP(™) FOR RELIEF OF SYMPTOMS IN RESTLESS LEGS SYNDROME (RLS) IN PATIENTS ON DIALYSIS
- Author
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Singh, Ravi Kumar, primary, Bhalla, Anil, additional, Rana, Ds, additional, Gupta, Ashwani, additional, Arijit, Jadiya, additional, and Singh, Deepika, additional
- Published
- 2019
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18. FP797TO STUDY THE GRAFT SURVIVAL AND PATIENT OUTCOME IN ABO INCOMPATIBLE KIDNEY TRANSPLANTS WITH BASELINE HIGH TITERS AND LOW TITERS COMPARED TO ABO COMPATIBLE KIDNEY TRANSPLANT
- Author
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Gaur, Lovy, primary, Bhalla, Ak, additional, Gupta, Ashwani, additional, Malik, M, additional, Shingada, Aakash, additional, Joshi, Anant, additional, Gupta, Anurag, additional, Bhargava, Vinant, additional, and Rana, Ds, additional
- Published
- 2019
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19. Pulmonary calcifications: Is it an entity in the new world dialysis patient?
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Bhargava, V, primary, Kauntia, R, additional, Gupta, P, additional, and Rana, DS, additional
- Published
- 2019
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20. Bladder carcinoma associated with BK virus in a renal allograft recipient
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Gaur, L, primary, Gupta, A, additional, Meena, P, additional, Shingada, A, additional, Gupta, P, additional, and Rana, DS, additional
- Published
- 2019
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21. Norovirus-associated hemolytic uremic syndrome in a renal transplant recipient
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Gaur, Lovy, primary, Gupta, Anurag, additional, Shingada, Aakash, additional, Bhalla, AK, additional, Gupta, Ashwani, additional, Malik, Manish, additional, Bhargava, Vinant, additional, and Rana, DS, additional
- Published
- 2018
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22. Yield and P uptake by wheat as affected by residual and applied P
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Vig, AC, Biswas, CR, Bahl, GS, and Rana, DS
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- 1983
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23. Magnetic, transport and 151Eu Mössbauer studies on partially doped La1 - x Eux Sr0.2 MnO3 ( 0.04 ≤ x ≤ 0.32) compounds
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RAKESH KUMAR, RANA, DS, TOMY, CV, PAULOSE, PL, and MALIK, SK
- Subjects
MöSsbauer Effect ,Colossal Magnetoresistance ,Magnetization - Abstract
Electrical resistivity, magnetic susceptibility and 151Eu Mössbauer studies have been carried out on La1-xEuxSr0.2MnO3 (0.04≤ x 0.32) compounds. As Eu substitution for La increases, the Curie temperature (TC) decreases from 261 K for x=0.04 to 187 K for x=0.16 along with a decrease in the metal–insulator transition temperature. However, the x=0.32 sample shows an increase in TC to 224 K along with an increase in the metal–insulator transition. The 151Eu Mössbauer studies show that all the Eu are in 3+(4f6,J=0) nonmagnetic state. Broadening of the Mössbauer spectra below TC indicates a transferred magnetic hyperfine field at the Eu site., © Elsevier
- Published
- 2006
24. Magnetic, specific heat and 151Eu Mössbauer studies on Ba2EuRu1-xCuO6(0≤x≤0.2) compounds
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RAKESH KUMAR, RANA, DS, TOMY, CV, PAULOSE, PL, NAGARAJAN, R, MIN, C, and OH, S-J
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Mossbauer Effect ,Thermal Variables Measurement ,Antiferromagnetism ,Data Acquisition ,Specific Heat ,Magnetization - Abstract
Magnetic, 151Eu Mössbauer and specific heat measurements have been carried out on image compounds. From the magnetization data, all the compounds are found to be antiferromagnetically ordered near 40 K, independent of Cu content. A sharp peak at 40 K in the specific heat data also confirms the magnetic ordering. The Eu ions in all the compounds are in the 3+ state as inferred from the 151Eu Mössbauer isomer shift values. However, a well split, six line pattern is observed in the 151Eu Mössbauer spectra of these compounds below 40 K. This is rather rare for image which is a nonmagnetic ion. The magnetic hyperfine field at the Eu site is found to be image at 4.2 K and is presumed to arise due to the strong Ru–O–Eu exchange interaction., © Elsevier
- Published
- 2006
25. Effect of Pr-Ca substitution on the transport and magnetic behavior of LaMnO3 perovskite
- Author
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Thaker, CM, Rayaprol, S, Mavani, Krushna, Rana, DS, Sahasrabudhe, MS, Patil, SI, and Kuberkar, DG
- Abstract
Abstract: The effect of simultaneous substitution of a fluctuating cation and a divalent cation in LaMnO
3 perovskite modifies the properties of the material to exhibit large valence colossal magnetoresistance (CMR) effect. A good example of these properties is (La1−2x Prx Cax )MnO3 (LPCMO) type CMR material. In this communication it is reported that, with the increase in x (for x=0.1, 0.15, 0.2), the Tc varies between 100 and 120 K with improvisation in metal-insulator transition. Interestingly, resistance increases with x from few hundred ohms to few kilo ohms with corresponding decrease in the unit cell volume. The results of the studies using X-ray diffraction (XRD), electrical resistivity, magnetoresistance and ac susceptibility measurements on LPCMO samples for understanding the structural, transport and magnetic properties are discussed in detail.- Published
- 2002
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26. Structural studies and Tc dependence in La2−xDyxCayBa2Cu4+yOz type mixed oxide superconductors
- Author
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Rayaprol, S, Mavani, Krushna, Thaker, CM, Rana, DS, Chakravorty, Keka, Paranjape, SK, Ramanadham, M, Kulkarni, Nilesh, and Kuberkar, DG
- Abstract
Abstract: A new series of mixed oxide superconductors with the stoichiometric composition La
2−x Dyx Cay Ba2 Cu4+y Oz (x=0.0 − 0.5, y=2x) has been studied for structural and superconductiong properties. Our earlier studies on La2−x (Y/Er)x Cay Ba2 Cu4+y Oz series, show a strong dependence of Tc on hole concentration (psh ). In the present work, the results of the analysis of the neutron diffraction measurements at room temprerature on x=0.3 and 0.5 samples are reported. It is interesting to know that Ca substitutes for both La and Ba site with concomitant displacement of La onto Ba site. Superconductivity studies show that maximum Tc is obtained for x=0.5, y=1.0 sample (Tc ∼ 75 K), for La1.5 Dy0.5 Ca1 Ba2 Cu5 Oz (La-2125).- Published
- 2002
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27. CAPD catheter obstruction by fallopian tubes.
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Sharma Y, Tiwari V, Tyagi V, Bhargava V, Gupta A, Malik M, Gupta A, Bhalla A, and Rana DS
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- Humans, Female, Fallopian Tubes diagnostic imaging, Fallopian Tubes surgery, Fallopian Tubes pathology, Middle Aged, Catheters, Indwelling adverse effects, Kidney Failure, Chronic therapy, Peritoneal Dialysis, Continuous Ambulatory instrumentation, Peritoneal Dialysis, Continuous Ambulatory adverse effects, Catheter Obstruction etiology
- Published
- 2024
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28. Indian Consensus on the Role and Position of Angiotensin Receptor-neprilysin Inhibitors in the Management of Heart Failure.
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Chopra HK, Ponde C, Wander GS, Nair T, Ray S, Khullar D, Nanda NC, Narula J, Kasliwal RR, Rana DS, Kirpalani A, Sawhney JS, Chandra P, Mehta Y, Kumar V, Tiwari S, Pancholia AK, Kher V, Bansal S, Mittal S, Kerkar P, Sahoo PK, Hotchandani R, Prakash S, Chauhan N, Rastogi V, Abdullakutty J, Shanmugasundaram S, Tiwaskar M, Sinha A, Gupta V, Mishra SS, Routray SN, Omar AK, Swami OC, Jaswal A, Alam S, Passey R, Rajput R, Paul J, Kapoor A, Dorairaj P, Chandra S, Malhotra P, Singh VP, Bansal M, Jain S, Shah P, Bhargava M, Vijayalakshmi IB, Varghaese K, Jain D, Goel A, Mahmood K, Gaur N, Tandon R, Moorthy A, George S, Katyal VK, Mantri RR, Mehrotra R, Bhalla D, Mittal V, Rao S, Jagia M, Singh H, Awasthi S, Sattur A, Mishra R, Pandey A, Chawla R, Jaggi S, Sehgal B, Sehgal A, Goel N, Gupta R, Kubba S, Chhabra A, Bagga S, and Shastry RN
- Subjects
- Humans, India, Consensus, Stroke Volume drug effects, Heart Failure drug therapy, Angiotensin Receptor Antagonists therapeutic use, Neprilysin antagonists & inhibitors
- Abstract
The incidence of heart failure (HF) in India is estimated to be 0.5-1.7 cases per 1,000 people per year, and approximately 4,92,000-1.8 million new cases are detected every year. Despite the high rate of mortality associated with HF, most patients do not receive maximal guideline-directed medical therapy (GDMT). Current guidelines advocate early multidrug combination therapy with four classes of drugs, namely, beta-blockers (BBs), mineralocorticoid receptor antagonists (MRAs), angiotensin receptor-neprilysin inhibitors (ARNIs), and sodium-glucose transport protein 2 inhibitors (SGLT-2is), particularly in patients with heart failure with reduced ejection fraction (HFrEF). ARNIs reduce cardiac morbidity and mortality in patients with HFrEF. However, recent data indicated that only 4.8% of patients with HFrEF receive ARNI in India. Hence, at a national consensus on HF meeting, cardiology experts from India formulated a national consensus on the use of ARNI in HF based on current evidence and guidelines. The consensus states that ARNI should be used early in HF, particularly in de novo patients with HFrEF, and those with acute decompensated heart failure (ADHF), irrespective of the presence of low systolic blood pressure (SBP) or diabetes. Moreover, those with HFrEF on renin-angiotensin-aldosterone system (RAAS) inhibitors should be switched to ARNI to reduce the risk of repeated hospitalization for HF, worsening HF, and cardiac death, and to improve the quality of life (QoL). Starting ARNI during the first hospitalization is preferable, and it is safe and effective across all doses. ARNIs can also be used for secondary benefits in patients with preserved ejection fraction [heart failure with preserved ejection fraction (HFpEF)] and HF with mildly reduced EF [heart failure with mildly reduced ejection fraction (HFmrEF)]., (© Journal of the Association of Physicians of India 2024.)
- Published
- 2024
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29. A novel mouth guard in endoscopy suite for limited oral access.
- Author
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Rana DS, Singh A, Swami AC, and Atolia NK
- Abstract
Competing Interests: There are no conflicts of interest.
- Published
- 2024
- Full Text
- View/download PDF
30. Impacts of conservation agriculture on crop yield and soil carbon sequestration: a meta-analysis in the Indian subcontinent.
- Author
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Padbhushan R, Kumar U, Sinha AK, Datta A, Mondal S, Rana DS, Mitra B, Bhattacharya PM, Kaviraj M, Kumar R, and Bijay-Singh
- Subjects
- India, Carbon analysis, Carbon Sequestration, Soil chemistry, Agriculture methods, Crops, Agricultural, Conservation of Natural Resources
- Abstract
In the quest of achieving sustainable crop productivity, improved soil health, and increased carbon (C) sequestration in the soil, conservation agriculture (CA) is increasingly being promoted and adopted in the Indian subcontinent. However, because some researchers from different regions of the world have reported reduced crop yield under CA relative to agriculture based on conventional tillage (CT), a meta-analysis has been conducted based on published research from India to evaluate the effects of CA on the yield of crops, accumulation of soil organic C as an index of soil health, and C sequestration in the soil in different regions and soil textural groups in the country. The meta-analysis is based on 544 paired observations under CA and CT from 35 publications from India was carried out using Meta Win 2.1 software. The results showed an overall significant (p < 0.05) reduction of 1.15% crop yield under CA compared to CT. Yearwise data showed a reduction of yields under CA from 2009 to 2016, but an increase from 2017 to 2020. Yield reduction was observed in the eastern, north-eastern, and southern regions of India but in western, northern, and north-western regions of the country, an increase was observed under CA rather than CT. Sandy loam and clayey soils exhibited higher crop yield under CA than under CT. Compared to CT, soil organic C content and soil C sequestration under CA increased by 8.9% and 7.3%, respectively. Also, in all the regions and soil textural groups both soil organic C accumulation and soil C sequestration were higher under CA than under CT. Factors such as rainfall, soil depth, available nitrogen (N), and total N significantly influenced the extent of yield increase/decrease and soil organic C accumulation under CA. Overall, results of the meta-analysis suggest that the promotion of CA in India will have to be location-specific taking into consideration the crops, soil attributes, and climatic conditions., (© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
- Published
- 2024
- Full Text
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31. Enhancing Success in the ABO-Incompatible Kidney Transplantation: A Case Report.
- Author
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Rana DS, Bhalla AK, Gupta A, Malik M, and Gupta A
- Abstract
Kidney transplantation is the preferred treatment for end-stage renal disease (ESRD); however, ABO incompatibility (ABOi) poses challenges due to increased graft rejection risk. Desensitization strategies, including immunoadsorption (IA), aim to overcome ABOi barriers. The objective of this case report was to present the initial findings and patient outcomes of ABOi kidney transplantation (KT) using two different brands of IA columns (Glycosorb
® ABO and SECORIM® -ABO) in reducing isoagglutinin titers to the desired target level. We present a case report of a 51-year-old male with ESRD secondary to diabetic kidney disease who underwent desensitization for ABOi KT, involving rituximab administration followed by IA using Glycosorb® and Vitrosorb SECORIM® -ABO columns and plasmapheresis (PP). Glycosorb® ABO column decreased anti-B titers from an initial level of 1:128/1:128 to 1:64/1:64 (target range ≤1:8); however, the titers rebounded to 1:64 following the fourth session of PP. Subsequent use of Vitrosorb SECORIM® -ABO column achieved target titers of 1:4, enabling successful transplantation with satisfactory graft function. Monitoring included anti-B IgG/IgM titer levels post IA columns, IA column reuse, kidney function, and adverse events. The IA columns were well tolerated. Desensitization using IA columns effectively reduced anti-B titers, facilitating successful ABOi KT., Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Rana et al.)- Published
- 2024
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32. Consensus Statement from India on the Renal Benefits of ARNi, SGLT-2i, and Bisoprolol in Chronic Kidney Disease.
- Author
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Chopra HK, Khullar D, Nair T, Wander GS, Ponde CK, Ray S, Nanda NC, Kasliwal RR, Rana DS, Kirpalani A, Sawhney J, Chandra P, Mehta Y, Kumar V, Tewari S, Pancholia AK, Kher V, Bansal S, Mittal S, Kerkar P, Sahoo PK, Hotchandani R, Prakash S, Chauhan N, Rastogi V, Jabir A, Shanmugasundaram S, Tiwaskar M, Sinha A, Gupta V, Mishra SS, Routray SN, Omar AK, Swami OC, Jaswal A, Alam S, Passey R, Rajput R, Paul J, Kapoor A, Prabhakar D, Chandra S, Malhotra P, Singh VP, Bansal M, Shah P, Jain S, Bhargava M, Vijayalakshmi IB, Varghaese K, Jain D, Goel A, Gaur N, Tandon R, Moorthy A, George S, Katyal VK, Mantri RR, Mehrotra R, Bhalla D, Mittal V, Rao S, Jagia M, Singh H, Awasthi S, Sattur A, Mishra R, Pandey A, Chawla R, Jaggi S, Sehgal B, Sehgal A, Goel N, Gupta R, Kubba S, Chhabra A, Bagga S, and Shastry NR
- Subjects
- Humans, India epidemiology, Consensus, Adrenergic beta-1 Receptor Antagonists therapeutic use, Renal Insufficiency, Chronic complications, Renal Insufficiency, Chronic drug therapy, Sodium-Glucose Transporter 2 Inhibitors therapeutic use, Bisoprolol therapeutic use, Angiotensin Receptor Antagonists therapeutic use
- Abstract
Chronic kidney disease (CKD) is a major contributor to morbidity and mortality in India. CKD often coexists with heart failure (HF), diabetes, and hypertension. All these comorbidities are risk factors for renal impairment. HF and CKD are pathophysiologically intertwined, and the deterioration of one can worsen the prognosis of the other. There is a need for safe renal pharmacological therapies that target both CKD and HF and are also useful in hypertension and diabetes. Neurohormonal activation achieved through the activation of the sympathetic nervous system (SNS), the renin-angiotensin-aldosterone system (RAAS), and the natriuretic peptide system (NPS) is fundamental in the pathogenesis and progression of CKD and HF. Angiotensin receptor neprilysin inhibitor (ARNi), sodium-glucose cotransporter 2 inhibitors (SGLT-2i), and selective β1-blocker (B1B) bisoprolol suppress this neurohormonal activation. They also have many other cardiorenal benefits across a wide range of CKD patients with or without concomitant HF, diabetes, or hypertension. This consensus statement from India explores the place of ARNi, SGLT-2i, and bisoprolol in the management of CKD patients with or without HF and other comorbidities., (© Journal of the Association of Physicians of India 2024.)
- Published
- 2024
- Full Text
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33. Parthenium hysterophorus derived nanostructures as an efficient carbocatalyst for the electrochemical sensing of mercury(II) ions.
- Author
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Sharma R, Rana DS, Gupta N, Thakur S, Thakur KK, and Singh D
- Subjects
- Parthenium hysterophorus, Carbon chemistry, Ions, Nitrogen chemistry, Oxygen, Mercury, Biosensing Techniques methods, Nanostructures chemistry
- Abstract
The sustainable utilization of resources motivate us to create eco-friendly processes for synthesizing novel carbon nanomaterials from waste biomass by minimizing chemical usage and reducing energy demands. By keeping sustainability as a prime focus in the present work, we have made the effective management of Parthenium weeds by converting them into carbon-based nanomaterial through hydrothermal treatment followed by heating in a tube furnace under the nitrogen atmosphere. The XPS studies confirm the natural presence of nitrogen and oxygen-containing functional groups in the biomass-derived carbon. The nanostructure has adopted a layered two-dimensional structure, clearly indicated through HRTEM images. Further, the nanomaterials are analyzed for their ability towards the electrochemical detection of mercury, with a detection limit of 6.17 μM, while the limit of quantification and sensitivity was found to be 18.7 μM and 0.4723 μM μA
-1 cm-2 , respectively. The obtained two-dimensional architecture has increased the surface area, while the nitrogen and oxygen functional groups act as an active site for sensing the mercury ions. This study will open a new door for developing metal-free catalysts through a green and sustainable approach by recycling and utilization of waste biomass., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)- Published
- 2024
- Full Text
- View/download PDF
34. Clinicopathologic Spectrum and Outcomes of Infections Diagnosed on Graft Biopsies and Nephrectomy in Live Renal Allograft Recipients: An Institutional Experience.
- Author
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Gupta P, Bhargava V, Malik M, Gupta A, Bhalla AK, Gupta A, Tiwari V, Chadha S, and Rana DS
- Subjects
- Humans, Retrospective Studies, Male, Female, Middle Aged, Adult, Biopsy, Treatment Outcome, Time Factors, Risk Factors, Allografts, Living Donors, Graft Survival, Turkey epidemiology, Aged, Pyelonephritis microbiology, Pyelonephritis diagnosis, Pyelonephritis mortality, Polyomavirus Infections diagnosis, Polyomavirus Infections mortality, Polyomavirus Infections virology, Polyomavirus Infections epidemiology, Polyomavirus Infections immunology, Kidney Transplantation adverse effects, Kidney Transplantation mortality, Nephrectomy adverse effects, Opportunistic Infections immunology, Opportunistic Infections mortality, Opportunistic Infections diagnosis, Opportunistic Infections microbiology, Opportunistic Infections virology, Opportunistic Infections epidemiology
- Abstract
Objectives: Modern immunosuppressive regimens have reduced rejection episodes in renal allograft recipients but have increased the risk of opportunistic infections. Infections are considered to be the second leading cause of death after cardiovascular complications in renal allograft recipients. Data on opportunistic infections affecting the allograft itself are scarce. The present study describes the spectrum of renal opportunistic infections and their outcomes diagnosed on renal allograft biopsies and nephrectomy specimens., Materials and Methods: Our retrospective observational study was conducted from December 2011 to December 2021. We analyzed infectious episodes diagnosed on renal allograft biopsies or graft nephrectomy specimens. We obtained clinical, epidemiological, and laboratory details for analyses from hospital records., Results: BK virus nephropathy was the most common opportunistic infection affecting the allograft, accounting for 47% of cases, followed by bacterial graft pyelonephritis (25%). Mucormycosis was the most common fungal infection. The diagnosis of infection from day of transplant ranged from 14 days to 39 months. Follow-up periods ranged from 1 to 10 years. Mortality was highest among patients with opportunistic fungal infection (62%), followed by viral infections, and graft failure rate was highest in patients with graft pyelonephritis (50%). Among patients with BK polyomavirus nephropathy, 45% had stable graft function compared with just 33% of patients with bacterial graft pyelonephritis., Conclusions: BK polyoma virus infection was the most common infection affecting the renal allograft in our study. Although fungal infections caused the highest mortality among our patients, bacterial graft pyelonephritis was responsible for maximum graft failure. Correctly identifying infections on histology is important so that graft and patient life can be prolonged.
- Published
- 2024
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35. Variation in performing kidney biopsy amongst nephrologists in the Asia-Pacific region: A multinational survey.
- Author
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Jasuja S, Jha V, Gallieni M, Rana DS, Vachharajani T, Sagar G, Bahl A, Tawakley S, and Gaur M
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- Humans, Cross-Sectional Studies, Kidney diagnostic imaging, Kidney pathology, Asia, Biopsy methods, Nephrologists, Nephrology education
- Abstract
Aim: Kidney biopsy (KB) is the gold standard procedure for diagnosing kidney diseases. Globally, nephrologists are trained to perform KB. However, the past few decades have witnessed a transition where interventional radiologists (IRs) are now preferentially performing the procedure. Our survey-based cross-sectional study aimed to investigate the current trends of KB operators in the Asia-Pacific region (APR) in practicing interventional nephrologists., Material and Methods: The Association of Vascular Access and intervenTionAl Renal Physicians (AVATAR) Foundation from India conducted a multinational online survey among interventional nephrologists from the APR to investigate who does KB, if the nephrology training curriculum includes KB, and whether nephrologists have access to ultrasound., Results: Out of 21 countries from the APR that participated in our survey, 10 countries (47.4%) reported that more than 70% of their nephrologists performed KB, whereas in 11 countries (57.6%), KB was most likely done by an IR. The frequency of nephrologists performing KB ranged from 0% in Afghanistan to 100% in countries such as Pakistan, Singapore, and Thailand. Formal training for KB and access to ultrasound was available to nephrologists in 80% of the responding countries., Conclusion: Our study shows that despite the availability of training and access to USG, a significant number of nephrologists are not performing KB in the APR. Similar to the trends observed in Western countries, the observed pattern in the APR could be due to lack of time, less incentive, hospital policy, or interest of nephrologists in other aspects of intervention nephrology.
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- 2024
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36. High-value crops' embedded groundnut-based production systems vis-à-vis system-mode integrated nutrient management: long-term impacts on system productivity, system profitability, and soil bio-fertility indicators in semi-arid climate.
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Bana RS, Choudhary AK, Nirmal RC, Kuri BR, Sangwan S, Godara S, Bansal R, Singh D, and Rana DS
- Abstract
The current study identified two new climate-resilient groundnut-based cropping systems (GBCSs), viz ., groundnut-fenugreek cropping system (GFCS) and groundnut-marigold cropping system (GMCS), with appropriate system-mode bio-compost embedded nutrient management schedules (SBINMSs) for semi-arid South Asia. This 5-year field study revealed that the GMCS along with leaf compost (LC) + 50% recommended dose of fertilizers (RDF
50 ) in wet-season crop (groundnut) and 100% RDF (RDF100 ) in winter-season crop (marigold) exhibited the highest system productivity (5.13-5.99 t/ha), system profits (US$ 1,767-2,688/ha), and soil fertility (available NPK). Among SBINMSs, the application of 5 t/ha leaf and cow dung mixture compost (LCMC) with RDF50 showed the highest increase (0.41%) in soil organic carbon (SOC) followed by LC at 5 t/ha with RDF50 and RDF100 . Legume-legume rotation (GFCS) had significantly higher soil microbial biomass carbon (SMBC) and soil microbial biomass nitrogen (SMBN) than legume-non-legume rotations (groundnut-wheat cropping system (GWCS) and GMCS). Among SBINMSs, the highest SMBC (201 µg/g dry soil) and SMBN (27.9 µg/g dry soil) were obtained when LCMC+RDF50 was applied to groundnut. The SMBC : SMBN ratio was the highest in the GWCS. LC+RDF50 exhibited the highest SMBC : SOC ratio (51.6). The largest increase in soil enzymatic activities was observed under LCMC+RDF50 . Overall, the GMCS with LC+RDF50 in the wet season and RDF100 in the winter season proved highly productive and remunerative with better soil bio-fertility. SBINMSs saved chemical fertilizers by ~25%' in addition to enhanced system productivity and system profits across GBCSs in semi-arid regions of South Asia. Future research needs to focus on studying the potential of diversified production systems on water and environmental footprints, carbon dynamics, and energy productivity under semi-arid ecologies., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Bana, Choudhary, Nirmal, Kuri, Sangwan, Godara, Bansal, Singh and Rana.)- Published
- 2024
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37. Comparison of Clinico-pathologic features and outcomes of ANCA negative and ANCA positive pauci immune crescentic glomerulonephritis: A single centre study.
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Gupta P, Bhargava V, Malik M, Gupta A, Bhalla AK, Gupta A, Tiwari V, Rana DS, and Sapra RL
- Subjects
- Humans, Antibodies, Antineutrophil Cytoplasmic, Kidney pathology, Kidney Glomerulus pathology, Acute Disease, Retrospective Studies, Glomerulonephritis pathology, Glomerulonephritis, Membranoproliferative pathology, Kidney Failure, Chronic pathology
- Abstract
Introduction: Pauci-immune crescentic glomerulonephritis (PICN) is an important cause of rapidly progressive renal failure. 10-40% of PICN cases have ANCA (antineutrophil cytoplasmic antibody) negative serology. The present study compared clinico-pathologic features, Brix's renal risk score, Berden's histopathological classes and differences in outcome between ANCAnegative vs ANCA positive PICN patients., Materials and Methods: Sixty-one patients of biopsy-proven PICN were studied. Biochemical findings and ANCA serology were recorded. Renal biopsy slides were reviewed along with direct immunofluorescence. Clinical and histological features were compared between ANCA negative and positive PICN using the Man Whitney U test and Chi-square test. Patients were compared for distribution in Berden's histological classes and Brix's renal risk categories. Patient and renal survival were compared using Kaplan-Meier survival analysis., Results: ANCA negative PICN patients were younger (44.9 ± 16.5 years vs 53.6 ± 15.1 years, P = 0.049). Nasal (0 vs 18%, P = 0.035) and pulmonary involvement (9% vs 38%, P = 0.014) were lower in ANCA negative group. Both ANCA groups had similar renal biochemical profiles, percentage normal glomeruli, 16.3 ± 18.2 vs 21.7 ± 20.4 and percentage glomeruli with crescents, 64.5 ± 28.1 vs 64.3 ± 27.1. Twenty-seven per cent of ANCA negative cases fell in the sclerotic class in Berden's classification vs just 2.5% in ANCA positive group (p = 0.037) without significant difference in Brix's renal risk categories (p = 0.329). Thirteen per cent of ANCA negative patients achieved complete remission on treatment compared to 33% in ANCA positive patients. Patient survival and overall probability of progressing to ESRD were similar in the two groups., Conclusion: ANCA negative PICN cases present at younger ages. Nasal and pulmonary involvement is uncommon in these patients. Patient survival and progression to ESRD are similar in both ANCA groups.
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- 2024
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38. The Promise of Cilnidipine in Hypertension with Comorbidities: National Consensus Statement: National Consensus Group Comprises Cardiologists, Nephrologists, and Diabetologists from India in a National Meet at New Delhi held on 22 nd May 2022.
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Chopra HK, Wander GS, Ponde CK, Nanda NC, Khullar D, Venugopal K, Ray S, Nair T, Rana DS, Kher V, Sawhney J, Kasliwal RR, Abdullakutty J, Chakraborty R, Chandra P, Bansal S, Kumar V, Pancholia AK, Kapoor A, Prakash S, Saxena A, Rastogi V, Sharma V, Arora YK, Dasbiswas A, Bhargava M, Jaswal A, Bhargava K, Bhatia M, Omar AK, Khanna NN, Passey R, Bhalla D, Vijayalakshmi IB, Bhalla AK, Moorthy A, Isser HS, Mishra SS, Routray S, Tandon V, Sinha A, Bansal M, Jain P, Hotchandani R, Jain D, Katyal VK, Gulati S, Tandon R, Jaggi S, Sehgal B, Gupta V, Mehrotra R, Krishnamani NC, Pathak SN, Yadav MS, Chawla R, Shastry NR, Chatterjee N, Samajdar SS, Pal J, and Tiwaskar M
- Subjects
- Humans, India epidemiology, Antihypertensive Agents therapeutic use, Consensus, Comorbidity, Hypertension drug therapy, Calcium Channel Blockers therapeutic use, Dihydropyridines therapeutic use
- Abstract
The rapidly increasing burden of hypertension is responsible for premature deaths from cardiovascular disease (CVD), renal disease, and stroke, with a tremendous public health and financial burden. Hypertension detection, treatment, and control vary worldwide; it is still low, particularly in low- and middle-income countries (LMICs). High blood pressure (BP) and CVD risk have a strong, linear, and independent association. They contribute to alarming numbers of all-cause and CVD deaths. A major culprit for increased hypertension is sympathetic activity, and further complications of hypertension are heart failure, ischemic heart disease (IHD), stroke, and renal failure. Now, antihypertensive interventions have emerged as a global public health priority to reduce BP-related morbidity and mortality. Calcium channel blockers (CCB) are highly effective vasodilators. and the most common drugs used for managing hypertension and CVD. Cilnidipine, with both L- and N-type calcium channel blocking activity, is a promising 4th generation CCB. It causes vasodilation via L-type calcium channel blockade and inhibits the sympathetic nervous system (SNS) via N-type calcium channel blockade. Cilnidipine, which acts as a dual L/N-type CCB, is linked to a reduced occurrence of pedal edema compared to amlodipine, which solely blocks L-type calcium channels. The antihypertensive properties of cilnidipine are very substantial, with low BP variability and long-acting properties. It is beneficial for hypertensive patients to deal with morning hypertension and for patients with abnormal nocturnal BP due to exaggerated sympathetic nerve activation. Besides its BP-lowering effect, it also exhibits organ protection via sympathetic nerve inhibition and renin-angiotensin-aldosterone system inhibition; it controls heart rate and proteinuria. Reno-protective, neuroprotective, and cardioprotective effects of cilnidipine have been well-documented and demonstrated., (© Journal of the Association of Physicians of India 2024.)
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- 2024
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39. ABO-Incompatible Renal Transplant: A Single-Center Experience from India.
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Pawar N, Tiwari V, Gupta A, Divyaveer S, Rather I, Chadha S, Bhargava V, Malik M, Gupta A, Bhalla AK, Rana DS, and Gupta P
- Abstract
Introduction: In view of ever-increasing end-stage renal disease (ESRD) population but inadequate availability of suitable donors, ABO-incompatible (ABOi) transplantation can be an important void filler. However, at present, ABOi transplantation is limited to a few centers in India and there is a lack of adequate experience and expertise to guide this program to other centers in the country., Methods: Data of all the ABOi transplants performed from 2012 to 2021 in a tertiary care hospital was retrospectively analyzed. The anti-ABO antibody (IgG) titers (≤1:4) were considered safe before transplantation. Desensitization included rituximab, plasma exchange, or selective immunoadsorption column. Tacrolimus and mycophenolate mofetil were initiated at day -7. Induction agents included ATG, ATLG, basiliximab, or no induction. Postoperatively, anti-ABO titers were done daily for 2 weeks., Results: A total of 202 patients underwent transplantation; of these, 195 patients whose data were for available for 12 months were included in the study. Mean duration of follow-up was 28.9 ± 21.7 months. UTI was the most common source of infection, occurring in almost half (46.1%) of the patients. Antibody-mediated rejection (ABMR; 15%) was common in the first year. Patient survival was 86.6% (169/195) at 1 year. Sepsis was the most common of death in more than two-thirds of the population, including coronavirus disease 2019 (COVID-19)-associated mortality in nine patients (4.6%). Death-censored graft survival was 89.3% (174/195). AMR was the leading cause of graft loss in almost half of the patients., Conclusion: ABOi should be considered in ESRD patients for whom suitable ABO-compatible donor is not available. Higher rate of rejection and infection are still a major concern., Competing Interests: There are no conflicts of interest., (© 2024 Indian Journal of Nephrology | Published by Scientific Scholar.)
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- 2024
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40. Current Place of SGLT2i in the Management of Heart Failure: An Expert Opinion from India.
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Chopra HK, Nair T, Wander GS, Ponde CK, Ray S, Khullar D, Nanda NC, Narula J, Kasliwal RR, Rana DS, Kirpalani A, Sawhney JPS, Chandra P, Mehta Y, Kumar V, Tewari S, Pancholia AK, Kher V, Bansal S, Mittal S, Kerkar P, Sahoo PK, Hotchandani R, Prakash S, Chauhan N, Rastogi V, Jabir A, Shanmugasundaram S, Tiwaskar M, Sinha A, Gupta V, Mishra SS, Routray SN, Omar AK, Swami OC, Jaswal A, Alam S, Passey R, Rajput R, Paul J, Kapoor A, Prabhakar D, Chandra S, Malhotra P, Singh VP, Bansal M, Shah P, Jain S, Bhargava M, Vijayalakshmi IB, Varghaese K, Jain D, Goel A, Mehmood K, Gaur N, Tandon R, Moorthy A, George S, Katyal VK, Mantri RR, Mehrotra R, Bhalla D, Mittal V, Rao S, Jagia M, Singh H, Awasthi S, Sattur A, Mishra R, Pandey A, Chawla R, Jaggi S, Sehgal B, Sehgal A, Goel N, Gupta R, Kubba S, Chhabra A, Bagga S, and Shastry NR
- Subjects
- Humans, India, Sodium-Glucose Transporter 2 Inhibitors therapeutic use, Heart Failure drug therapy, Diabetes Mellitus, Type 2 drug therapy, Diabetes Mellitus, Type 2 complications
- Abstract
Heart failure (HF) is a global health concern that is prevalent in India as well. HF is reported at a younger age in Indian patients with comorbidity of type 2 diabetes (T2DM) in approximately 50% of patients. Sodium-glucose cotransporter-2 inhibitors (SGLT2i), originally approved for T2DM, are new guideline-recommended and approved treatment strategies for HF. Extensive evidence highlights that SGLT2i exhibits profound cardiovascular (CV) benefits beyond glycemic control. SGLT2i, in conjunction with other guideline-directed medical therapies (GMDT), has additive effects in improving heart function and reducing adverse HF outcomes. The benefits of SGLT2i are across a spectrum of patients, with and without diabetes, suggesting their potential place in broader HF populations irrespective of ejection fraction (EF). This consensus builds on the updated evidence of the efficacy and safety of SGLT2i in HF and recommends its place in therapy with a focus on Indian patients with HF., (© Journal of the Association of Physicians of India 2024.)
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- 2024
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41. Nitrogen and sulfur functionalized microporous carbon nanomaterial derived from waste coconut husk for the efficient detection and removal of ofloxacin.
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Sharma R, Thakur J, Jaryal VB, Rana DS, Thakur S, Gupta N, and Singh D
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- Cocos, Nitrogen chemistry, Sulfur, Carbon chemistry, Nanostructures
- Abstract
This study uses waste coconut husk to synthesize carbon quantum dots decorated graphene-like structure for sustainable detection and removal of ofloxacin. The XRD spectrum shows the carbon nanomaterial's layered structure with turbostratic carbon stacking on its surface. The FESEM and HRTEM studies claim the successful development of quantum dots decorated 2D layered structure of carbon nanomaterial. The functionalization of sulfur and nitrogen is well observed and studied through XPS, while Raman spectra have provided insight into the surface topology of the as-synthesized nanostructure. The BET surface area was found to be 1437.12 m
2 /g with a microporous structure (pore width 2.0 nm) which interestingly outcompete many reported carbon-based nanomaterials such as graphene oxide, reduced graphene oxide and quantum dots. The detection and removal processes are monitored through UV-visible spectroscopy and the obtained detection limit and adsorption capacity were 2.7 nM and 393.94 mg/L respectively. Additionally, 1 mg carbon nanomaterial has removed 49 % ofloxacin from water in just 1 h. In this way, this study has successfully managed the coconut husk waste after its utilization for environmental remediation purposes., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Ltd. All rights reserved.)- Published
- 2024
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42. Prevalence, risk, and outcomes of venous thromboembolic events in kidney transplant recipients: a nested case-control study.
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Bhargava V, Meena P, Bhalla AK, Rana DS, Gupta A, Malik M, Gupta A, and Tiwari V
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- Adult, Humans, Case-Control Studies, Prevalence, Risk Factors, Retrospective Studies, Venous Thromboembolism epidemiology, Kidney Transplantation adverse effects, Venous Thrombosis etiology
- Abstract
Introduction: Thromboembolism is more common in kidney transplant recipients (KTRs) than in the general population. Studies evaluating arterial and venous thromboembolism (VTE) in KTRs are scarce and the magnitude and risk factors are mostly undefined., Methods: A nested control study was conducted from January 1, 2007, to December 31, 2019. Adult KTRs who were detected to have VTE events during this period were included. The primary outcome was to assess the prevalence of VTE in this population. Secondary outcomes were the assessment of the time to occurrence of the thromboembolic events after transplantation and assessing the risk factors and patient survival. For each subject studied, 4 controls were matched from the data set., Results: Amongst 2158 patients, 97 (4.5%) were found to have VTE. The median follow-up time was 3.9 years (6-156 months). A total of 101 VTE events were recorded. The most common site of VTE was the lower limb deep vein thrombosis in 79 patients (0.03%)).In multivariate Cox regression analysis, serum creatinine of more than 3 mg/dl [HR 1.30, 95% CI (1.03-1.38)] was independently associated with increased VTE risk. Patients who developed a VTE had higher mortality as compared to patients who did not develop VTE. No increased risk of graft failure was found in VTE patients., Conclusion: This study suggests that kidney transplantation surgery is a moderate risk factor for VTE, and VTE is associated with higher morbidity and mortality. However, prospective studies are needed to establish a definite role of VTE in outcomes in KTRs.
- Published
- 2023
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43. Comprehensive overview of 2022 human monkeypox outbreak and its pathology, prevention, and treatment: A strategy for disease control.
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Yashavarddhan MH, Bohra D, Rana R, Tuli HS, Ranjan V, Rana DS, and Ganguly NK
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- Animals, Humans, Disease Outbreaks prevention & control, Public Health, Africa, Mpox (monkeypox) epidemiology, Mpox (monkeypox) prevention & control, Oils, Volatile
- Abstract
The 2022 Monkeypox virus, an evolved DNA strain originating in Africa, exhibits heightened human-to-human transmissibility and potential animal transmission. Its host remains unidentified. While its initial slow transmission rate restrained global impact, 2022 saw a surge in cases, causing widespread concern in over 103 countries by September. This virus's distinctive human-to-human transmission marks a crucial shift, demanding a prompt revaluation of containment strategies. However, the host source for this shift requires urgent research attention. Regrettably, no universal preventive or curative methods have emerged for this evolved virus. Repurposed from smallpox vaccines, only some vaccinations offer a partial defense. Solely one therapeutic drug is available. The article's essence is to provide a comprehensive grasp of the virus's epidemiology, morphology, immune invasion mechanisms, and existing preventive and treatment measures. This knowledge equips researchers to devise strategies against its spread and potential public health implications., Competing Interests: Declaration of Competing Interest The authors declare no conflict of interest., (Copyright © 2023 Elsevier GmbH. All rights reserved.)
- Published
- 2023
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44. Role of Bisoprolol in Heart Failure Management: A Consensus Statement from India.
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Chopra HK, Nair T, Wander GS, Ponde CK, Ray S, Khullar D, Nanda NC, Kasliwal RR, Rana DS, Kirpalani A, Sawhney JPS, Chandra P, Mehta Y, Kumar V, Tewari S, Pancholia AK, Kher V, Bansal S, Mittal S, Kerkar P, Sahoo PK, Hotchandani R, Prakash S, Chauhan N, Rastogi V, Jabir A, Shanmugasundaram S, Tiwaskar M, Sinha A, Gupta V, Mishra SS, Routray SN, Omar AK, Swami OC, Jaswal A, Alam S, Passey R, Rajput R, Paul J, Kapoor A, Prabhakar D, Chandra S, Malhotra P, Singh VP, Bansal M, Shah P, Jain S, Bhargava M, Vijayalakshmi IB, Varghaese K, Jain D, Goel A, Gaur N, Tandon R, Moorthy A, George S, Katyal VK, Mantri RR, Mehrotra R, Bhalla D, Mittal V, Rao S, Jagia M, Singh H, Awasthi S, Sattur A, Mishra R, Pandey A, Chawla R, Jaggi S, Sehgal B, Sehgal A, Goel N, Gupta R, Kubba S, Chhabra A, Bagga S, and Shastry NR
- Subjects
- Humans, India, Consensus, Bisoprolol therapeutic use, Heart Failure drug therapy, Adrenergic beta-1 Receptor Antagonists therapeutic use
- Abstract
In India, heart failure (HF) is an important health concern affecting younger age groups than the western population. A limited number of Indian patients receive guideline-directed medical therapy (GDMT). Selective β-1 blockers (BB) are one of the GDMTs in HF and play an important role by decreasing the sympathetic overdrive. The BB reduces heart rate (HR) reverse the adverse cardiac (both ventricular and atrial), vascular, and renovascular remodeling seen in HF. Bisoprolol, a β-1 blocker, has several advantages and can be used across a wide spectrum of HF presentations and in patients with HF and comorbid conditions such as coronary artery disease (CAD), atrial fibrillation (AF), post-myocardial infarction (MI), uncontrolled diabetes, uncontrolled hypertension, and renal impairment. Despite its advantages, bisoprolol is not optimally utilized for managing HF in India. This consensus builds on updated evidence on the efficacy and safety of bisoprolol in HF and recommends its place in therapy with a focus on Indian patients with HF., (© Journal of the Association of Physicians of India 2023.)
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- 2023
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45. Practice of dialysis access interventional nephrology procedures in the Asia-Pacific region: Getting lay of the land.
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Jasuja S, Gallieni M, Jha V, Vachharajani T, Bhalla AK, Tan J, Tan CS, Basnet NB, Herath N, Hai An HP, Kim YS, Kim Y, SampathKumar K, Sahay M, Ramachandran R, Alexander S, Bhargava V, Balasubramaniam J, Voss D, Ogbac FE, Gunawan A, Goh BL, Lin CC, Khan J, Shiham I, Ayub H, Hein MA, Iqbal S, Srisawat N, Gao B, Sajiv C, Wilkinson C, Pichthida T, Rana DS, Sagar G, Bahl A, Tawakley S, and Gaur M
- Subjects
- Humans, Renal Dialysis, Cross-Sectional Studies, Catheterization methods, Asia epidemiology, Nephrology education
- Abstract
Aim: This cross-sectional survey aimed to determine the prevalence of Interventional Nephrology (IN) practice amongst nephrologists in the Asia-Pacific Region (APR), specifically related to dialysis access (DA)., Methods: The Association of VA and intervenTionAl Renal physicians (AVATAR) Foundation from India conducted a multinational online survey amongst nephrologists from the Asia-Pacific to determine the practice of IN in the planning, creation, and management of dialysis access. The treatment modalities, manpower and equipment availability, monthly cost of treatment, specifics of dialysis access interventions, and challenges in the training and practice of IN by nephrologists were included in the survey., Results: Twenty-one countries from the APR participated in the survey. Nephrologists from 18 (85.7%) countries reported performing at least one of the basic dialysis access-related IN procedures, primarily the placement of non-tunnelled central catheters (n-TCC; 71.5%). Only 10 countries (47.6%) reported having an average of <4% of nephrologists performing any of the advanced IN access procedures, the most common being the placement of a peritoneal dialysis (PD) catheter (20%). Lack of formal training (57.14%), time (42.8%), incentive (38%), institutional support (38%), medico-legal protection (28.6%), and prohibitive cost (23.8%) were the main challenges to practice IN. The primary obstacles to implementing the IN training were a lack of funding and skilled personnel., Conclusion: The practice of dialysis access-related IN in APR is inadequate, mostly due to a lack of training, backup support, and economic constraints, whereas training in access-related IN is constrained by a lack of a skilled workforce and finances., (© 2023 Asian Pacific Society of Nephrology.)
- Published
- 2023
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46. Donor-Derived Cell-Free DNA as a Non-Invasive Biomarker for Graft Rejection in Kidney Transplant Recipients: A Prospective Study among the Indian Population.
- Author
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Kumar N, Tandon A, Rana R, Rana DS, Bhalla AK, Gupta A, Sachdeva MP, Huirem RS, Chauhan K, Yashavarddhan MH, Basnal A, Gupta R, Mallick PK, and Ganguly NK
- Abstract
Monitoring graft health and detecting graft rejection is crucial for the success of post-transplantation outcomes. In Western countries, the use of donor-derived cell-free DNA (dd-cfDNA) has gained widespread recognition as a diagnostic tool for kidney transplant recipients. However, the role of dd-cfDNA among the Indian population remains unexplored. The recipients were categorized into two groups: the post-transplant recipient (PTR) group ( n = 16) and the random recipient (RR) group ( n = 87). Blood samples were collected daily from the PTR group over a 7-day period, whereas the RR group's samples were obtained at varying intervals. In this study, we used a targeted approach to identify dd-cfDNA, which eliminated the need for genotyping, and is based on the minor allele frequency of SNP assays. In the PTR group, elevated dd-cfDNA% levels were observed immediately after transplantation, but returned to normal levels within five days. Within the RR group, heightened serum creatinine levels were directly proportional to increased dd-cfDNA%. Sixteen recipients were advised to undergo biopsy due to elevated serum creatinine and other pathological markers. Among these sixteen recipients, six experienced antibody-mediated rejection (ABMR), two exhibited graft dysfunctions, two had active graft injury, and six (37.5%) recipients showed no rejection (NR). In cases of biopsy-proven ABMR and NR, recipients displayed a mean ± SD dd-cfDNA% of 2.80 ± 1.77 and 0.30 ± 0.35, respectively. This study found that the selected SNP assays exhibit a high proficiency in identifying donor DNA. This study also supports the use of dd-cfDNA as a routine diagnostic test for kidney transplant recipients, along with biopsies and serum creatinine, to attain better graft monitoring.
- Published
- 2023
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47. Heparin-Induced Thrombocytopenia in Hemodialysis Patients- The First Study from India.
- Author
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Sivaprakasam Y, Chadha S, Kotwal J, Gupta A, Tiwari V, Bhargava V, Mallik M, Gupta A, Bhalla AK, and Rana DS
- Abstract
Heparin-induced thrombocytopenia (HIT), a rare complication of heparin therapy, presents with thrombocytopenia. It leads to paradoxical thromboembolism and has high mortality if untreated. It is less recognized, especially in hemodialysis (HD) patients who are frequently exposed to heparin during dialysis because patients with renal failure may have many other causes of thrombocytopenia. We describe the clinical presentation, diagnosis, and treatment of five cases of confirmed HIT in hemodialysis (HD) patients at our center. The initial suspicion was made based on a high 4T score and positive gel card test followed by confirmation using the functional assay with heparin-induced platelet aggregation. These patients were treated according to the recent American Society of Hematology guidelines 2018 for HIT., Competing Interests: There are no conflicts of interest., (Copyright: © 2023 Indian Journal of Nephrology.)
- Published
- 2023
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48. Nocardiosis in Renal Transplantation: Case Series from India.
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Bhandari G, Tiwari V, Gupta A, Bhargava V, Malik M, Gupta A, Bhalla AK, and Rana DS
- Abstract
Nocardiosis is a rare opportunistic infection seen in kidney transplant patients and is caused by aerobic actinomycete. Disease manifestations can vary from a localized infection to multisystem organ failure. In this retrospective case series, we present 16 cases of Nocardiosis. The median age of the patients was 44 years. The median time from transplant to nocardiosis was 21 months. Acute rejection episodes and CMV infection within 6 months of nocardiosis were found in 12.5% and 25%, respectively. The most common organ involvement was the lungs (75%), followed by the brain (12.5%). Only one patient showed cutaneous involvement (6.25%). Mean creatinine at presentation was 0.7 mg/dL (mean eGFR: 92 ± 27 mL/min/1.73 m
2 ). Trimethoprim/sulfamethoxazole resistance was found in 25% of patients. Five patients (31.25%) succumbed to the infection. Nocardiosis has a very low incidence but a high rate of mortality., Competing Interests: There are no conflicts of interest., (Copyright: © 2023 Indian Journal of Nephrology.)- Published
- 2023
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49. Development of metal free carbon catalyst derived from Parthenium hysterophorus for the electrochemical detection of dopamine.
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Rana DS, Sharma R, Gupta N, Sharma V, Thakur S, and Singh D
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- Humans, Reproducibility of Results, Electrochemical Techniques methods, Metals, Plant Extracts, Carbon, Dopamine chemistry
- Abstract
Parthenium hysterophorus, one of the seven most hazardous weeds is widely known for its allergic, respiratory and skin-related disorders. It is also known to affect biodiversity and ecology. For eradication of the weed, its effective utilization for the successful synthesis of carbon-based nanomaterial is a potent management strategy. In this study, reduced graphene oxide (rGO) was synthesized from weed leaf extract through a hydrothermal-assisted carbonization method. The crystallinity and geometry of the as-synthesized nanostructure are confirmed from the X-ray diffraction study, while the chemical architecture of the nanomaterial is ascertained through X-ray photoelectron spectroscopy. The stacking of flat graphene-like layers with a size range of ∼200-300 nm is visualized through high-resolution transmission electron microscopy images. Further, the as-synthesized carbon nanomaterial is advanced as an effective and highly sensitive electrochemical biosensor for dopamine, a vital neurotransmitter of the human brain. Nanomaterial oxidizes dopamine at a much lower potential (0.13 V) than other metal-based nanocomposites. Moreover, the obtained sensitivity (13.75 and 3.31 μA μM
-1 cm-2 ), detection limit (0.6 and 0.8 μM), the limit of quantification (2.2 and 2.7 μM) and reproducibility calculated through cyclic voltammetry/differential pulse voltammetry respectively outcompete many metal-based nanocomposites that were previously used for the sensing of dopamine. This study boosts the research on the metal-free carbon-based nanomaterial derived from waste plant biomass., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Inc. All rights reserved.)- Published
- 2023
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50. NOTTO Guidelines for Vaccine Induced Thrombotic Thrombocytopenia in Organ Donation and Transplantation.
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Kute V, Asthana S, Gupta S, Agarwal SK, Swarnalatha G, Sahay M, Pal S, Sudhindran S, Sharma A, Seth S, Gokhale AGK, Hote MD, Chaudhury AR, Soin AS, Rela M, Malhotra R, Bansal VK, Rana DS, and Ramesh V
- Abstract
From the context of organ donation, COVID-19 vaccine-induced thrombotic thrombocytopenia (VITT) is important as there is an ethical dilemma in utilizing versus discarding organs from potential donors succumbing to VITT. This consensus statement is an attempt by the National Organ and Tissue Transplant Organization (NOTTO) apex technical committees India to formulate the guidelines for deceased organ donation and transplantation in relation to VITT to help in appropriate decision making. VITT is a rare entity, but a meticulous approach should be taken by the Organ Procurement Organization's (OPO) team in screening such cases. All such cases must be strictly notified to the national authorities like NOTTO, as a resource for data collection and ensuring compliance withprotocols in the management of adverse events following immunization. Organs from any patient who developed thrombotic events up to 4 weeks after adenoviral vector-based vaccination should be linked to VITT and investigated appropriately. The viability of the organs must be thoroughly checked by the OPO, and the final decision in relation to organ use should be decided by the expert committee of the OPO team consisting of a virologist, a hematologist, and atreating team. Considering the organ shortage, in case of suspected/confirmed VITT, both clinicians and patients should consider the risk-benefit equationbased on available experience, and an appropriate written informed consent of potential recipients and family members should be obtained before transplantation of organs from suspected or proven VITT donors., Competing Interests: There are no conflicts of interest., (Copyright: © 2023 Indian Journal of Nephrology.)
- Published
- 2023
- Full Text
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