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18 results on '"Rana, Hafsa"'

1. Herpes simplex virus spreads rapidly in human foreskin, partly driven by chemokine-induced redistribution of Nectin-1 on keratinocytes

Author

Rana, Hafsa, primary, Truong, Naomi R., additional, Johnson, Blake, additional, Baharlou, Heeva, additional, Herbert, Jason J., additional, Kandasamy, Sasikaran, additional, Goddard, Robert, additional, Cohen, Ralph C., additional, Wines, Michael, additional, Nasr, Najla, additional, Harman, Andrew N., additional, Bertram, Kirstie M., additional, Sandgren, Kerrie J., additional, and Cunningham, Anthony L., additional

Published
2024
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2. Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells

Author

Rhodes, Jake W., Botting, Rachel A., Bertram, Kirstie M., Vine, Erica E., Rana, Hafsa, Baharlou, Heeva, Vegh, Peter, O’Neil, Thomas R., Ashhurst, Anneliese S., Fletcher, James, Parnell, Grant P., Graham, J. Dinny, Nasr, Najla, Lim, Jake J. K., Barnouti, Laith, Haertsch, Peter, Gosselink, Martijn P., Di Re, Angelina, Reza, Faizur, Ctercteko, Grahame, Jenkins, Gregory J., Brooks, Andrew J., Patrick, Ellis, Byrne, Scott N., Hunter, Eric, Haniffa, Muzlifah A., Cunningham, Anthony L., and Harman, Andrew N.

Published
2021
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6. Microbial risk assessment and antimicrobial resistance

Author

Ahmed, Sarfraz, primary, Ibrahim, Muhammad, additional, Ahmad, Fiaz, additional, Rana, Hafsa Anwar, additional, Rao, Tazeen, additional, Anwar, Wajiha, additional, Younus, Muhammad, additional, Ahmad, Waqas, additional, Farooqi, Shahid Hussain, additional, Aftab, Asma, additional, Hussain, Munawar, additional, Khalid, Muhammad, additional, and Kamal, Ghulam Mustafa, additional

Published
2020
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7. Contributors

Author

Arooj, Taha, primary, Aftab, Asma, additional, Afzaal, Muhammad, additional, Ahmad, Ali, additional, Ahmad, Fiaz, additional, Ahmad, Waqas, additional, Ahmed, Sarfraz, additional, Ahmed, Iftikhar, additional, Ain, Noor Ul, additional, Akash, Muhammad Sajid Hamid, additional, Akram, Qaisar, additional, Ali, Rizwan, additional, Ali, Jafar, additional, Ali, Muhammad Ishtiaq, additional, Ali, Zeshan, additional, Ali Mirza, Safdar, additional, Ali Taseer, Muhammad Sulman, additional, Almas, Muniza, additional, Amin, Arshia, additional, Amin, Mehroze, additional, Andleeb, Saadia, additional, Anjum, Muzammil, additional, Anwar, Wajiha, additional, Arshad, Muhammad, additional, Ashfaq, Muhammad, additional, Ashraf, Hajra, additional, Ateeq, Basit, additional, Awan, Muhammad Umer Farooq, additional, Balabanova, B., additional, Bashour, Isam, additional, Batool, Tahira, additional, Begum, Sajida, additional, Bukhari, Syeda Aniqa, additional, Chaudhry, Zoma, additional, Chohan, Tahir Ali, additional, Das, Surojeet, additional, Dilshad, Erum, additional, El-Gemayel, Lara, additional, Farooqi, Shahid Hussain, additional, Fiayyaz, Fareeha, additional, Fiaz, Marium, additional, Habib, Sahrish, additional, Hashmi, Muhammad Zaffar, additional, Hassan, Jouman, additional, Hussain, Munawar, additional, Ibrahim, Muhammad, additional, Igrejas, Gilberto, additional, Imran, Ayesha, additional, Iqbal, Muhammad Javed, additional, Jabeen, Komal, additional, Javed, Deeba, additional, Kabeer, Ayesha, additional, Kamal, Ghulam Mustafa, additional, Kamran, Saira Hafeez, additional, Kassem, Issmat I., additional, Kathi, Srujana, additional, Khalid, Muhammad, additional, Khurshid, Mohsin, additional, Kumar, Sunil, additional, Liaqat, Iram, additional, Majid, Mahnoor, additional, Manzoor, Bushra, additional, Mazhar, Iqra, additional, Meer, Bisma, additional, Mehmood, Sajid, additional, Mumtaz, Arooj, additional, Naveed, Muhammad, additional, Niaz, Sania, additional, Pervaiz, Waqar, additional, Poeta, Patrícia, additional, Raja, Hafsa, additional, Ramzan, Ayesha, additional, Rana, Hafsa Anwar, additional, Rao, Tazeen, additional, Rashid, Umer, additional, Rehman, Kanwal, additional, Rehman, Muhammad Saif Ur, additional, Riaz, Luqman, additional, Sabir, Shakila, additional, Safeer, Rabia, additional, Saima, Saima, additional, Saleem ur Rehman, Hamza, additional, Sardar, Sumbal, additional, Shahab, Asfandyar, additional, Shifaqat, Sana, additional, Sikandar, Anila, additional, Silva, Adriana, additional, Silva, Vanessa, additional, Srivastava, Aashna, additional, Tahir, Ayesha, additional, Ullah, Habib, additional, Victor, Francis, additional, Wang, Qianqian, additional, Waseem, Hassan, additional, Yang, Qingxiang, additional, Yaqub, Bushra, additional, Younus, Muhammad, additional, Yuan, Wei, additional, Zafar, Rabeea, additional, and Zahra, Tehseen, additional

Published
2020
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9. Plasmacytoid dendritic cells have divergent effects on HIV infection of initial target cells and induce a pro-retention phenotype

Author

Tong, Orion, Duette, Gabriel, O'Neil, Thomas Ray, Royle, Caroline M., Rana, Hafsa, Johnson, B., Brouwer, M.A.E., Cunningham, Anthony L., Nasr, Najla, Tong, Orion, Duette, Gabriel, O'Neil, Thomas Ray, Royle, Caroline M., Rana, Hafsa, Johnson, B., Brouwer, M.A.E., Cunningham, Anthony L., and Nasr, Najla

Abstract

Contains fulltext : 233590.pdf (Publisher’s version ) (Open Access)

Published
2021

10. Herpes Simplex Virus type 1 infects Langerhans cells and the novel epidermal dendritic cell, Epi-cDC2s, via different entry pathways

Author

Bertram, Kirstie M., primary, Truong, Naomi R., additional, Smith, Jacinta B., additional, Kim, Min, additional, Sandgren, Kerrie J., additional, Feng, Konrad L., additional, Herbert, Jason J., additional, Rana, Hafsa, additional, Danastas, Kevin, additional, Miranda-Saksena, Monica, additional, Rhodes, Jake W., additional, Patrick, Ellis, additional, Cohen, Ralph C., additional, Lim, Jake, additional, Merten, Steven L., additional, Harman, Andrew N., additional, and Cunningham, Anthony L., additional

Published
2021
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11. Plasmacytoid dendritic cells have divergent effects on HIV infection of initial target cells and induce a pro-retention phenotype

Author

Tong, Orion, primary, Duette, Gabriel, additional, O’Neil, Thomas R., additional, Royle, Caroline M., additional, Rana, Hafsa, additional, Johnson, Blake, additional, Popovic, Nicole, additional, Dervish, Suat, additional, Brouwer, Michelle A. E., additional, Baharlou, Heeva, additional, Patrick, Ellis, additional, Ctercteko, Grahame, additional, Palmer, Sarah, additional, Lee, Eunok, additional, Hunter, Eric, additional, Harman, Andrew N., additional, Cunningham, Anthony L., additional, and Nasr, Najla, additional

Published
2021
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12. Identification of HIV-Transmitting Sub-Epithelial Mononuclear Phagocytes in Human Anogenital and Colorectal Tissues

Author

Rhodes, Jake W, primary, Botting, Rachel A, additional, Bertram, Kirstie M, additional, Rana, Hafsa, additional, Baharlou, Heeva, additional, Longmuir-Vine, Erica E, additional, Vegh, Peter, additional, Fletcher, James, additional, O’Neil, Thomas R, additional, Parnell, Grant P, additional, Graham, J Dinny, additional, Nasr, Najla, additional, Lim, Jake J K, additional, Barnouti, Laith, additional, Haertsch, Peter, additional, Gosselink, Martijn P, additional, Di Re, Angelina, additional, Ctercteko, Grahame, additional, Jenkins, Gregory J, additional, Brooks, Andrew J, additional, Patrick, Ellis, additional, Byrne, Scott N, additional, Haniffa, Muzlifah A, additional, Cunningham, Anthony L, additional, and Harman, Andrew N, additional

Published
2020
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14. Identification of HIV transmitting CD11c+ human epidermal dendritic cells

Author

Bertram, Kirstie M., primary, Botting, Rachel A., additional, Baharlou, Heeva, additional, Rhodes, Jake W., additional, Rana, Hafsa, additional, Graham, J. Dinny, additional, Patrick, Ellis, additional, Fletcher, James, additional, Plasto, Toby M., additional, Truong, Naomi R., additional, Royle, Caroline, additional, Doyle, Chloe M., additional, Tong, Orion, additional, Nasr, Najla, additional, Barnouti, Laith, additional, Kohout, Mark P., additional, Brooks, Andrew J., additional, Wines, Michael P., additional, Haertsch, Peter, additional, Lim, Jake, additional, Gosselink, Martijn P., additional, Ctercteko, Grahame, additional, Estes, Jacob D., additional, Churchill, Melissa J., additional, Cameron, Paul U., additional, Hunter, Eric, additional, Haniffa, Muzlifah A., additional, Cunningham, Anthony L., additional, and Harman, Andrew N., additional

Published
2019
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15. Phenotypic and functional consequences of different isolation protocols on skin mononuclear phagocytes

Author

Botting, Rachel A, primary, Bertram, Kirstie M, additional, Baharlou, Heeva, additional, Sandgren, Kerrie J, additional, Fletcher, James, additional, Rhodes, Jake W, additional, Rana, Hafsa, additional, Plasto, Toby M, additional, Wang, Xin Maggie, additional, Lim, Jake J K, additional, Barnouti, Laith, additional, Kohout, Mark P, additional, Papadopoulos, Tim, additional, Merten, Steve, additional, Olbourne, Norman, additional, Cunningham, Anthony L, additional, Haniffa, Muzlifah, additional, and Harman, Andrew N, additional

Published
2017
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17. Identification of HIV transmitting CD11c+ human epidermal dendritic cells.

Author

Bertram, Kirstie M., Botting, Rachel A., Baharlou, Heeva, Rhodes, Jake W., Rana, Hafsa, Graham, J. Dinny, Patrick, Ellis, Fletcher, James, Plasto, Toby M., Truong, Naomi R., Royle, Caroline, Doyle, Chloe M., Tong, Orion, Nasr, Najla, Barnouti, Laith, Kohout, Mark P., Brooks, Andrew J., Wines, Michael P., Haertsch, Peter, and Lim, Jake

Abstract

Langerhans cells (LC) are thought to be the only mononuclear phagocyte population in the epidermis where they detect pathogens. Here, we show that CD11c+ dendritic cells (DCs) are also present. These cells are transcriptionally similar to dermal cDC2 but are more efficient antigen-presenting cells. Compared to LCs, epidermal CD11c+ DCs are enriched in anogenital tissues where they preferentially interact with HIV, express the higher levels of HIV entry receptor CCR5, support the higher levels of HIV uptake and replication and are more efficient at transmitting the virus to CD4 T cells. Importantly, these findings are observed using both a lab-adapted and transmitted/founder strain of HIV. We also describe a CD33low cell population, which is transcriptionally similar to LCs but does not appear to function as antigen-presenting cells or acts as HIV target cells. Our findings reveal that epidermal DCs in anogenital tissues potentially play a key role in sexual transmission of HIV. Composition and function of immune populations at barrier surfaces is crucial for response to infection. Here, the authors identify a population of dendritic cells in human epidermis, abundant in anogenital epithelia and distinct from Langerhans cells by surface phenotype and by high capacity for HIV infection and transmission. [ABSTRACT FROM AUTHOR]

Published
2019
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18. Identification of HIV transmitting CD11c + human epidermal dendritic cells.

Author

Bertram KM, Botting RA, Baharlou H, Rhodes JW, Rana H, Graham JD, Patrick E, Fletcher J, Plasto TM, Truong NR, Royle C, Doyle CM, Tong O, Nasr N, Barnouti L, Kohout MP, Brooks AJ, Wines MP, Haertsch P, Lim J, Gosselink MP, Ctercteko G, Estes JD, Churchill MJ, Cameron PU, Hunter E, Haniffa MA, Cunningham AL, and Harman AN

Subjects
Antigen Presentation immunology, CD11c Antigen metabolism, Cells, Cultured, Dendritic Cells immunology, Dendritic Cells metabolism, Epidermal Cells immunology, Epidermal Cells metabolism, Epidermis immunology, Female, HIV Infections immunology, HIV Infections virology, HIV-1 pathogenicity, Healthy Volunteers, Humans, Male, Primary Cell Culture, Receptors, CCR5 metabolism, Sialic Acid Binding Ig-like Lectin 3 metabolism, T-Lymphocytes immunology, Virus Internalization, Dendritic Cells virology, Epidermal Cells virology, HIV Infections transmission, HIV-1 immunology
Abstract

Langerhans cells (LC) are thought to be the only mononuclear phagocyte population in the epidermis where they detect pathogens. Here, we show that CD11c + dendritic cells (DCs) are also present. These cells are transcriptionally similar to dermal cDC2 but are more efficient antigen-presenting cells. Compared to LCs, epidermal CD11c + DCs are enriched in anogenital tissues where they preferentially interact with HIV, express the higher levels of HIV entry receptor CCR5, support the higher levels of HIV uptake and replication and are more efficient at transmitting the virus to CD4 T cells. Importantly, these findings are observed using both a lab-adapted and transmitted/founder strain of HIV. We also describe a CD33 low cell population, which is transcriptionally similar to LCs but does not appear to function as antigen-presenting cells or acts as HIV target cells. Our findings reveal that epidermal DCs in anogenital tissues potentially play a key role in sexual transmission of HIV.

Published
2019
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