1. N-Methylpurine DNA Glycosylase and OGG1 DNA Repair Activities: Opposite Associations With Lung Cancer Risk
- Author
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Gad Rennert, Edna Schechtman, Tamar Paz-Elizur, Ziv Sevilya, Mila Pinchev, Zvi Livneh, Hedy S. Rennert, Yael Leitner-Dagan, Dalia Elinger, Laurence S. Freedman, Ran Kramer, and Laila C. Roisman
- Subjects
Adult ,Male ,Oncology ,Cancer Research ,medicine.medical_specialty ,Lung Neoplasms ,DNA Repair ,DNA repair ,Biology ,Brief Communication ,Peripheral blood mononuclear cell ,DNA Glycosylases ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Risk Factors ,Internal medicine ,Biomarkers, Tumor ,Odds Ratio ,medicine ,Genetic predisposition ,Humans ,Lung cancer ,Aged ,030304 developmental biology ,0303 health sciences ,Odds ratio ,Middle Aged ,medicine.disease ,Confidence interval ,3. Good health ,Logistic Models ,chemistry ,DNA glycosylase ,Case-Control Studies ,030220 oncology & carcinogenesis ,Immunology ,Leukocytes, Mononuclear ,Female ,DNA - Abstract
Only a minority of smokers develop lung cancer, possibly due to genetic predisposition, including DNA repair deficiencies. To examine whether inter-individual variations in DNA repair activity of N-methylpurine DNA glycosylase (MPG) are associated with lung cancer, we conducted a blinded, population-based, case–control study with 100 lung cancer case patients and 100 matched control subjects and analyzed the data with conditional logistic regression. All statistical tests were two-sided. MPG enzyme activity in peripheral blood mononuclear cells from case patients was higher than in control subjects, results opposite that of 8-oxoguanine DNA glycosylase (OGG1) DNA repair enzyme activity. For lung cancer associated with one standard deviation increase in MPG activity, the adjusted odds ratio was 1.8 (95% confidence interval [CI] = 1.2 to 2.6; P = .006). A combined MPG and OGG1 activities score was more strongly associated with lung cancer risk than either activity alone, with an odds ratio of 2.3 (95% CI = 1.4 to 3.6; P < .001). These results form a basis for a future panel of risk biomarkers for lung cancer risk assessment and prevention.
- Published
- 2012
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