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6 results on '"Ramya Priya Rallapeta"'

1. Clinical utility of reverse perfusion pattern with 99mTc myocardial stress perfusion scintigraphy

Author

Nimmagadda Ajit, Ranadheer Gupta Manthri, Vanajakshamma Velam, V S Krishna Mohan, Ramya Priya Rallapeta, and Tek Chand Kalawat

Subjects
99mtc methoxy isobutyl isonitrile, 99mtc myocardial perfusion scintigraphy, reverse distribution, reverse perfusion, Medicine
Abstract

Background: Reverse distribution is a pattern that is occasionally observed with 99mTc sestamibi myocardial stress perfusion scintigraphy. The actual cause for this kind of pattern to occur is still under evaluation with no specific aetiology identified. Methods: We retrospectively studied 1195 patients who underwent 99mTc sestamibi myocardial stress perfusion scintigraphy. There was no history of acute myocardial infraction 1 month before the scan; no prior percutaneous transluminal coronary angioplasty was performed in any of these patients. Twenty-seven patients (2.2%) were found to have reverse distribution pattern based on the criteria after ruling out artefacts. Results: Their mean age was 53.5 ± 10.4 years; there were 18 females. Their mean body mass index (BMI) was 27.6 ± 3.4 kg/m2. Six patients had a history of hypertension, 4 patients had a history of diabetes mellitus and 2 patients had both before the scan. Scan findings suggested low probability for coronary artery disease (CAD) in 24 patients and high probability for CAD in three patients. Left anterior descending artery (LAD) territory, posterior descending artery and left circumflex (LCX) artery territory were involved in 22, 8 and 1 patient respectively. The mean time of follow-up was 36.3 ± 4.3 months. None of the patients later had any recurrent episode of chest pain or worsening of symptoms or sentinel events such as death after the scan. Conclusions: Reverse distribution pattern is sometimes observed with 99mTc-MIBI stress MPI. Such a finding has minimal prognostic significance, especially in patients with low and intermediate probability for CAD on imaging.

Published
2023
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2. Metabolically quiescent paraganglioma in a patient with carcinoma cervix: An unusual presentation

Author

D S Hemalatha, Ramya Priya Rallapeta, Ranadheer Gupta Manthri, Tekchand C Kalawat, Narendra Hulikal, and Aruna Prayaga

Subjects
18f-fluorodeoxyglucose, positron-emission tomography computerised tomography non-18f-fluorodeoxyglucose-avid, paraganglioma, pheochromocytoma, retroperitoneal tumour, Medicine
Abstract

Paragangliomas (PGLs) are rare tumours arising from sympathetic and parasympathetic paraganglial neural crest cells. Functional PGLs usually present with manifestations of catecholamine excess such as hypertension, flushing and diaphoresis. Non-functional PGLs are diagnosed incidentally during imaging studies and pose a significant diagnostic challenge. Here, we report the case of 42-year-old female patient with carcinoma cervix who presented with a non-fluorodeoxyglucose-avid PGL. This case report highlights the importance of considering PGL in differential diagnosis and the management of retroperitoneal tumours.

Published
2020
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3. Comparison of automatic depth correction versus manual depth correction in the calculation of glomerular filtration rate in gates renal processing of diethylenetriaminepentaacetic acid renogram in prospective renal donors

Author

Ranadheer Mantri, Priyanka Kosana, Ramya Priya Rallapeta, Ravi Parthasaradhi, Sailaja Aka, Tekchand Kalawat, and Siva Kumar Vishnubotla

Subjects
depth correction, diethylenetriaminepentaacetic acid renogram, glomerular filtration rate calculation, Surgery, RD1-811
Abstract

Aim: The aim of the study was to compare the glomerular filtration rate (GFR) obtained by gates method of renal processing using automated system generated method (ASGM) of depth correction with manual depth correction method (MDCM), in prospective renal donors using 99m-Tc diethylenetriaminepentaacetic acid (DTPA) scintigraphy. Materials and Methods: Prospective interventional study involving 20 voluntary renal donors of age 26–65 years were included. 99m-Tc DTPA renograms were acquired by dynamic acquisition for 30 min. Presyringe and postsyringe counts, prevoid and postvoid images, and both sides of lateral images (for manual depth correction) were acquired. GFR was calculated by Gates renal processing with the depth correction both by ASGM and MDCM methods. Results: The mean depth of right and left kidneys calculated by MDCM and ASGM were 7.2 ± 1.1 and 6.4 ± 1.1 and 7.0 ± 1.2 and 6 ± 1.2, respectively. The mean total GFR calculated by Gate's Method using MDCM and ASGM was 96.2 ± 15.4 and 82.0 ± 11.5. There was a statistically significant difference in the depth correction of both kidneys and improvement in total GFR values by MDCM methods compared to the ASGM method. Conclusion: There was a significant difference in depth and GFR values, calculated from MDCM compared to ASGM. Hence, the MDCM is better in calculating GFR for renal donors, especially when using low-energy high-resolution collimators, as full-width half-maximum varies considerably for every centimeter of the distance of the source from the collimator.

Published
2019
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4. Preparation of 177Lu-PSMA-617 in Hospital Radiopharmacy: Convenient Formulation of a Clinical Dose Using a Single-Vial Freeze-Dried PSMA-617 Kit Developed In-House

Author

Ajit Nimmagadda, Parthasarathy Ravi, Tapas Das, Mohini Guleria, Ramya Priya Rallapeta, Tekchand Kalawat, V S Krishnamohan, Jeyachitra Amirdhanayagam, Sailaja Patri, and Haladhar Dev Sarma

Subjects
Male, Metastatic lesions, Article Subject, 177Lu-PSMA-617, Drug Compounding, In Vitro Techniques, Lutetium, urologic and male genital diseases, Vial, General Biochemistry, Genetics and Molecular Biology, Heterocyclic Compounds, 1-Ring, Therapeutic index, Drug Stability, Positron Emission Tomography Computed Tomography, Animals, Humans, Medicine, Tissue Distribution, In patient, Rats, Wistar, Radioisotopes, Radiochemistry, General Immunology and Microbiology, business.industry, Prostatic Neoplasms, Dipeptides, General Medicine, Prostate carcinoma, Prostate-Specific Antigen, Rats, Prostatic Neoplasms, Castration-Resistant, Freeze Drying, Nuclear Pharmacy, Patient dose, Radiopharmaceuticals, Pharmacy Service, Hospital, business, Nuclear medicine, Research Article
Abstract

Objective. In the recent time, endoradionuclide therapy for metastatic castration-resistant prostate carcinoma employing 177Lu-PSMA-617 has yielded encouraging results and several clinical trials with the agent are currently ongoing. Routine preparation of 177Lu-PSMA-617 patient doses can be made simpler and convenient, if the ingredients essential for radiolabeling are made available in a ready-to-use lyophilized form. Methods. PSMA-617 freeze-dried kit was formulated and used for the preparation of 177Lu-PSMA-617 clinical dose with high radiochemical purity using low/medium specific activity 177Lu. Detailed radiochemical studies were performed to determine the maximum activity and volume of 177LuCl3, which can be added in the kit for the formulation of 177Lu-PSMA-617. Studies were also performed to determine the shelf life of the kit to ensure its long-term usage. Studies were performed in buffer as well as human serum medium to determine the stability of the 177Lu-PSMA-617 complex after storing in respective media up to 7 days postpreparation. About ten patient doses of 177Lu-PSMA-617 were administered, and posttherapy scans were acquired. Results. The formulated freeze-dried kit of PSMA-617 could be radiolabeled with an average percentage radiochemical purity > 98.53 ± 0.38 . The freeze-dried kit was found suitable for tolerating up to 0.5 mL of 177LuCl3 (in 0.01 N HCl) and specific activity of 555 MBq/μg (15 mCi/μg) for the preparation of the patient dose of 177Lu-PSMA-617. The 177Lu-PSMA-617 complex prepared using the freeze-dried kit of PSMA-617 was observed to maintain % radiochemical purity (RCP) of 96.74 ± 0.87 and 94.81 ± 2.66 , respectively, even after storing up to 7 days in buffer and human serum, respectively. 177Lu-PSMA-617 prepared using the in-house formulated freeze-dried kit of PSMA-617 exhibited accumulation in metastatic lesions picked up in a pretherapy PET scan. Reduction in number as well as size of lesions was observed in posttherapy scans acquired after two months of administering the first therapeutic dose of 177Lu-PSMA-617. Conclusions. The freeze-dried kit of PSMA-617 could be used for the preparation of 177Lu-PSMA-617 with high radiochemical purity (>98%) in a reproducible manner. 177Lu-PSMA-617 prepared using the developed kit was successfully evaluated in patients suffering from metastatic prostate cancer.

Published
2021

5. Utility of Short-Acting Intravenous Insulin Therapy in Preparation of F-18 Fluorodeoxyglucose Positron Emission Tomography Computed Tomography Scan in Cancer Patients Incidentally Detected with High Blood Glucose Levels on the Day of Test

Author

Ramya Priya, Rallapeta, Ranadheer Gupta, Manthri, Tekchand, Kalawat, Alok, Sachan, A Y, Lakshmi, and Narendra, Hulikal

Subjects
intravenous insulin, F-18 fluorodeoxyglucose positron emission tomography computed tomography, diabetes mellitus, Original Article, hyperglycemia, Cancer
Abstract

Background: In diabetic (DM) patients, hyperglycemia degrades image quality in F-18 FDG PET CT by altering bio-distribution of FDG in the body and augmenting soft tissue and muscular uptake. We intend to evaluate the use of short acting I.V insulin in minimising the rescheduling of patients detected with FBG>160 mg/dL on the day of scan. Aim and Objectives: To show the utility of short acting IV insulin therapy in preparation of cancer patients incidentally detected with high blood glucose levels for F-18 FDG PET CT scan, (>160mg/dL) and to compare the obtained image quality with patients detected with fasting blood glucose level (FBG) 160 mg/dL, Group II (n=349): DM patients with FBG

Published
2020

6. Papillary Carcinoma Thyroid Metastases Presenting as Thyrotoxicosis Post Thyroidectomy - A Case Report

Author

Kanala Sai Krishnaja, Mehabunnisa Shaik, Ramya Priya Rallapeta, Ranadheer Gupta Manthri, Tekchand Kalawat, and Suresh Vaikkakara

Subjects
medicine.medical_specialty, endocrine system, Papillary carcinoma thyroid, medicine.medical_treatment, papillary carcinoma thyroid, 030209 endocrinology & metabolism, Case Report, 03 medical and health sciences, 0302 clinical medicine, medicine, Radiology, Nuclear Medicine and imaging, 030212 general & internal medicine, thyrotoxicosis, Thyroid cancer, Total thyroidectomy, Lung, business.industry, Thyroidectomy, medicine.disease, medicine.anatomical_structure, Functioning metastases, Cervical lymph nodes, Scalp, Thyroglobulin, Radiology, business
Abstract

Thyrotoxicosis can occur in the setting of differentiated thyroid cancer due to functioning metastases. Here, we report a case of a 63 year old woman with papillary carcinoma thyroid who underwent total thyroidectomy and defaulted for further scheduled treatment with high dose radioactive iodine therapy. 2 years after total thyroidectomy, she presented with signs and symptoms of thyrotoxicosis and a scalp swelling on the right side of frontal region. Excision biopsy revealed metastatic deposits of papillary carcinoma thyroid. Even after withdrawal of thyroxine, her serum thyrotropin did not rise and thyroglobulin levels were high, raising the suspicion of high volume tumour burden. I-131 whole body scan was done and it revealed radio iodine avid cervical lymph nodes along with functioning lung and skeletal metastases.

Published
2019

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