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Introduction: Infection-related glomerulonephritis, IRGN in adults is increasing in prevalence in India. However, there are only a few prospective studies from south India on the long term prognosis of this disease. Materials and Methods: This is a prospective observational study on patients above 18 years of age, with biopsy proven IRGN, at a tertiary care centre in south India with a minimum follow up of 6 months. Results: A total of 100 patients were included in the study. Peak incidence was in the age group of 40-60 years (n=45, 45%) with a male preponderance (n=56,56%). The most common co-morbidities were diabetes mellitus (n=27, 27%) and alcohol intake (n=13,13%). The most common source of infection was skin and soft tissues (n=41, 41%). Streptococcus and Staphylococcus were the most common isolated organisms. One patient had IRGN following SARS C0V-2 virus infection. Twenty three (n=23, 23%) required dialysis initiation. The mean follow up was 31.4 weeks. 3 patients died within 1 month of illness. At the end of 6 months, out of the 97 surviving patients, 34 (n=34,35%) patients had chronic kidney disease, CKD (eGFR 40 years, associated diabetes mellitus,underlying CKD, dialysis requiring renal failure at presentation,presence of crescentric GN and moderate to severe Interstitial Fibrosis and Tubular Atrophy in renal biopsy were identified as risk factors for development of CKD by univariate analysis. Conclusion: Adult IRGN is as an important cause of CKD and end stage renal disease in Indian adults especially in diabetics and those above 40 years of age.

Background: Despite the increasing proportion of the elderly population, renal biopsies are restricted to few centers. We studied the elderly renal biopsy data from a tertiary care center in South India. Materials and Methods: A retrospective observational study was done in patients more than 60 years of age who underwent native kidney biopsy for various clinical indications from January 2014 to June 2022 and was compared with the renal pathology data of adults 18-60 years of age who underwent native kidney biopsy for various indications during the same study. Results: Hundred and five (n = 105) elderly biopsies were included in the study. The mean age was 65.7 years (interquartile range: 60-85 years). Forty-two (40%) were type 2 diabetics. Infection-related glomerulonephritis (IRGN) (20, 19.04%), acute tubular necrosis (ATN) (15, 14.28%), membranous nephropathy (11, 10.47%), and acute interstitial nephritis (10, 9.52%) were the common pathologies observed in the elderly. The most common indication for renal biopsy was rapidly progressive renal failure (RPRF) (n = 28, 26.6%) and IRGN was the most common cause of RPRF. 76.2% of diabetics had nondiabetic renal disease, the most common being IRGN (8, 25%). Crescentic glomerulonephritis (GN), ATN, and cast nephropathy were observed significantly more frequent in the elderly than in those 18-60 years of age. IRGN and pauci-immune vasculitis were the causes of crescentic GN in the elderly. Conclusion: Our study highlights the importance of IRGN as the most frequent pathology in the South Indian elderly population both in diabetics and nondiabetics. [ABSTRACT FROM AUTHOR]