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16. Differences in clinical features and mortality in very old unvaccinated patients (≥ 80 years) hospitalized with COVID-19 during the first and successive waves from the multicenter SEMI-COVID-19 Registry (Spain)

Author

Ramos-Rincon, Jose-Manuel, Cobos-Palacios, Lidia, López-Sampalo, Almudena, Ricci, Michele, Rubio-Rivas, Manel, Nuñez-Rodriguez, Maria-Victoria, Miranda-Godoy, Rodrigo, García-Leoni, Maria-Eugenia, Fernández-Madera-Martínez, Rosa, García-García, Gema-María, Beato-Perez, Jose-Luis, Monge-Monge, Daniel, Asín-Samper, Uxua, Bustamante-Vega, Marta, Rábago-Lorite, Isabel, Freire-Castro, Santiago-Jesús, Miramontes-González, Jose-Pablo, Magallanes-Gamboa, Jeffrey-Oskar, Alcalá-Pedrajas, José-Nicolás, García-Gómez, Miriam, Cano-Llorente, Verónica, Carrasco-Sánchez, Francisco-Javier, Martinez-Carrilero, Jesús, Antón-Santos, Juan-Miguel, and Gómez-Huelgas, Ricardo

Published
2022
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18. Changes in the Objective Structured Clinical Examination (OSCE) of University Schools of Medicine during COVID-19. Experience with a computer-based case simulation OSCE (CCS-OSCE)

Author

López-Román, Antonio, Cardoner-Álvarez, Narcís, Lorenzo-Peñuelas, Antonio, Párraga-Ramírez, Manuel, Jiménez-Reina, Luis, Sanz-Álvarez, Emilio J., Naranjo-Hernández, Antonio, Valdivielso-Felices, Pedro, Ramos-Rincón, José Manuel, Adánez-Martínez, Gracia, García-Salom, Miguel, Lafuente-Sánchez, José Vicente, Martínez-Ibargüen, Agustín, Fernández-Agulló, Teresa, Castro-Salomó, Antoni, Sancho-Sánchez, María Consuelo, Hermida-Ameijeiras, Álvaro, Ambrosiani-Fernández, Jesús, García-Seoane, J.J., Ramos-Rincón, J.M., and Lara-Muñoz, J.P.

Published
2021
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19. Cambios en el examen clínico objetivo y estructurado (ECOE) de las facultades de Medicina durante la COVID-19. Experiencia de una ECOE de casos-clínicos computarizados simulados (ECOE-CCS) conjunta

Author

López-Román, Antonio, Cardoner-Álvarez, Narcís, Lorenzo-Peñuelas, Antonio, Párraga-Ramírez, Manuel, Jiménez-Reina, Luis, Sanz-Álvarez, Emilio J., Naranjo-Hernández, Antonio, Valdivielso-Felices, Pedro, Ramos-Rincón, José Manuel, Adánez-Martínez, Gracia, García-Salom, Miguel, Martínez-Ibargüen, Agustín, Lafuente-Sánchez, José Vicente, Fernández-Agulló, Teresa, Castro-Salomó, Antoni, Sancho-Sánchez, María Consuelo, Hermida-Ameijeiras, Álvaro, Ambrosiani-Fernández, Jesús, García-Seoane, J.J., Ramos-Rincón, J.M., and Lara-Muñoz, J.P.

Published
2021
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22. Cytokine profile levels and their relationship with parasitemia and cardiomyopathy in people with Chagas disease in Spain. A prospective observational study

Author

Ramos-Rincon, Jose-Manuel, primary, Torrús-Tendero, Diego, additional, García-Morante, Hilarion, additional, Gimeno-Gascón, Adelina, additional, Marco, Francisco, additional, Gil-Anguita, Concepción, additional, Wikman-Jorgensen, Philip, additional, Lucas-Dato, Ana, additional, Rodriguez-Diaz, Juan-Carlos, additional, Amador, Concepción, additional, and Llenas-García, Jara, additional

Published
2023
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25. Executive summary of imported infectious diseases after returning from foreign travel: Consensus document of the Spanish Society for Infectious Diseases and Clinical Microbiology (SEIMC)

Author

Pérez-Arellano, José Luis, Górgolas-Hernández-Mora, Miguel, Salvador, Fernando, Carranza-Rodríguez, Cristina, Ramírez-Olivencia, Germán, Martín-Echeverría, Esteban, Rodríguez-Guardado, Azucena, Norman, Francesca, Velasco-Tirado, Virginia, Zubero-Sulibarría, Zuriñe, Rojo-Marcos, Gerardo, Muñoz-Gutierrez, José, Ramos-Rincón, José Manuel, Sánchez-Seco-Fariñas, M. Paz, Velasco-Arribas, María, Belhassen-García, Moncef, Lago-Nuñez, Mar, Cañas García-Otero, Elías, and López-Vélez, Rogelio

Published
2018
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26. Incidence of Cerebral Palsy, Risk Factors, and Neuroimaging in Northeast Mexico

Author

Barron-Garza, Fabiola, primary, Coronado-Garza, Mario, additional, Gutierrez-Ramirez, Sixto, additional, Ramos-Rincon, Jose-Manuel, additional, Guzman-de la Garza, Francisco, additional, Lozano-Morantes, Alexia, additional, Flores-Rodriguez, Anahi, additional, Nieto-Sanjuanero, Adriana, additional, Alvarez-Villalobos, Neri, additional, Flores-Villarreal, Maribel, additional, and Covarrubias-Contreras, Luz, additional

Published
2023
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28. Transient Changes in the Plasma of Astrocytic and Neuronal Injury Biomarkers in COVID-19 Patients without Neurological Syndromes

Author

Lennol, Matthew P., primary, Ashton, Nicholas J., additional, Moreno-Pérez, Oscar, additional, García-Ayllón, María-Salud, additional, Ramos-Rincon, Jose-Manuel, additional, Andrés, Mariano, additional, León-Ramírez, José-Manuel, additional, Boix, Vicente, additional, Gil, Joan, additional, Blennow, Kaj, additional, Merino, Esperanza, additional, Zetterberg, Henrik, additional, and Sáez-Valero, Javier, additional

Published
2023
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30. Transfusion-transmitted arboviruses: Update and systematic review

Author

Giménez-Richarte, Ángel, primary, Ortiz de Salazar, María Isabel, additional, Giménez-Richarte, María-Paz, additional, Collado, Miriam, additional, Fernández, Pedro Luís, additional, Clavijo, Carlos, additional, Navarro, Laura, additional, Arbona, Cristina, additional, Marco, Pascual, additional, and Ramos-Rincon, Jose-Manuel, additional

Published
2022
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31. Severe Spontaneous Hematomas in Patients Hospitalized with COVID-19.

Author

Otero-Rodriguez, Silvia, Guillen, Cristina, Mataix, Maria, Gonzalez-de-la-Aleja, Pilar, Cruces-Fuentes, Elisabeth, Mantilla-Pinilla, Alix Juliette, Moreno-Perez, Oscar, Sanchez-Martinez, Rosario, Merino, Esperanza, and Ramos-Rincon, Jose-Manuel

Abstract

Objective. To describe the epidemiological, clinical, laboratory, and radiological characteristics, medical treatment, and outcomes of a case series of severe spontaneous hematoma in COVID-19. Material and Methods. This retrospective study included patients hospitalized for COVID-19 who were diagnosed with severe spontaneous bleeding complications by following a standardized treatment protocol that included computed tomography angiography (CTA) from 1 March 2020 to 28 February 2022. The main outcomes were embolization and all-cause mortality. Baseline variables were analyzed for their association with mortality using bivariable logistic regression, and results were expressed as odds ratios (OR) and 95% confidence intervals (CI). Results. In total, 2450 adults were hospitalized for COVID-19 in our center during the study period. 20 patients presented severe and spontaneous intramuscular bleeding (8.1 per 1000 COVID-19 admission vs. 0.47 per 1000 non-COVID-19 admissions, p < 0.001); their median age was 68.5 years (interquartile range (IQR) 63, 80), they had high comorbidity (median Charlson comorbidity index 4.5), and 95% were receiving high doses of heparin. The median interval from COVID-19 symptoms to bleeding was 17 days (IQR 13, 24), and 70% reported cough as a previous symptom. Hypovolemic shock, hypotension, and abdominal pain were the most frequent symptoms of the hematoma. All presented decreased hemoglobin, and 95% required transfusion. Intramuscular hematoma occurred most frequently in the rectus sheath, iliopsoas compartment, and femoral-iliac compartment. All patients underwent embolization; mortality was 45%. We did not identify risk factors associated with an increased risk of death. Conclusion. Although severe bleeding is an uncommon complication of COVID-19, its prevalence is higher than in inpatients without COVID-19, it usually needs embolization, and it is associated with high mortality. [ABSTRACT FROM AUTHOR]

Published
2023
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32. Nosocomial COVID-19: A Nationwide Spanish Study.

Author

Ramos-Rincon, Jose-Manuel, Lopez-Sampalo, Almudena, Cobos-Palacios, Lidia, Ricci, Michele, Rubio-Rivas, Manel, Díaz-Simón, Raquel, Martín-Escalante, María-Dolores, Castañeda-Pérez, Sabela, Fernández-Madera-Martínez, Rosa, Beato-Perez, Jose-Luis, García-García, Gema-Maria, García-Andreu, María-del-Mar, Arnalich-Fernandez, Francisco, Molinos-Castro, Sonia, Vargas-Núñez, Juan-Antonio, Artero, Arturo, Freire-Castro, Santiago-Jesús, Fernández-Gómez, Jennifer, Cubo-Romano, Pilar, and Hernández-Milián, Almudena

Subjects
*COVID-19, *COVID-19 pandemic, *ADULT respiratory distress syndrome, *LOGISTIC regression analysis, *AGE groups
Abstract

Introduction: SARS-CoV-2 is a highly contagious virus, and despite professionals' best efforts, nosocomial COVID-19 (NC) infections have been reported. This work aimed to describe differences in symptoms and outcomes between patients with NC and community-acquired COVID-19 (CAC) and to identify risk factors for severe outcomes among NC patients. Methods: This is a nationwide, retrospective, multicenter, observational study that analyzed patients hospitalized with confirmed COVID-19 in 150 Spanish hospitals (SEMI-COVID-19 Registry) from March 1, 2020, to April 30, 2021. NC was defined as patients admitted for non-COVID-19 diseases with a positive SARS-CoV-2 test on the fifth day of hospitalization or later. The primary outcome was 30-day in-hospital mortality (IHM). The secondary outcome was other COVID-19-related complications. A multivariable logistic regression analysis was performed. Results: Of the 23,219 patients hospitalized with COVID-19, 1,104 (4.8%) were NC. Compared to CAC patients, NC patients were older (median 76 vs. 69 years; p < 0.001), had more comorbidities (median Charlson Comorbidity Index 5 vs. 3; p < 0.001), were less symptomatic (p < 0.001), and had normal chest X-rays more frequently (30.8% vs. 12.5%, p < 0.001). After adjusting for sex, age, dependence, COVID-19 wave, and comorbidities, NC was associated with lower risk of moderate/severe acute respiratory distress syndrome (ARDS) (adjusted odds ratio [aOR]: 0.72; 95% confidence interval [CI]: 0.59–0.87; p < 0.001) and higher risk of acute heart failure (aOR: 1.40; 1.12–1.72; p = 0.003), sepsis (aOR: 1.73; 1.33–2.54; p < 0.001), and readmission (aOR: 1.35; 1.03–1.83; p = 0.028). NC was associated with a higher case fatality rate (39.1% vs. 19.2%) in all age groups. IHM was significantly higher among NC patients (aOR: 2.07; 1.81–2.68; p < 0.001). Risk factors for increased IHM in NC patients were age, moderate/severe dependence, malignancy, dyspnea, moderate/severe ARDS, multiple organ dysfunction syndrome, and shock; odynophagia was associated with lower IHM. Conclusions: NC is associated with greater mortality and complications compared to CAC. Hospital strategies to prevent NC must be strengthened. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Pathological Findings Associated With SARS-CoV-2 on Postmortem Core Biopsies: Correlation With Clinical Presentation and Disease Course

Author

Ramos-Rincon, Jose-Manuel, primary, Herrera-García, Cristian, additional, Silva-Ortega, Sandra, additional, Portilla-Tamarit, Julia, additional, Alenda, Cristina, additional, Jaime-Sanchez, Francisco-Angel, additional, Arenas-Jiménez, Juan, additional, Fornés-Riera, Francisca-Eugenia, additional, Scholz, Alexander, additional, Escribano, Isabel, additional, Pedrero-Castillo, Víctor, additional, Muñoz-Miguelsanz, Carlos, additional, Orts-Llinares, Pedro, additional, Martí-Pastor, Ana, additional, Amo-Lozano, Antonio, additional, García-Sevila, Raquel, additional, Ribes-Mengual, Isabel, additional, Moreno-Perez, Oscar, additional, Concepcion-Aramendía, Luis, additional, Merino, Esperanza, additional, Sánchez-Martínez, Rosario, additional, and Aranda, Ignacio, additional

Published
2022
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34. In-hospital mortality due to extrapulmonary tuberculosis according to clinical and ultrasound features in Chókwè District, Mozambique. Retrospective hospital-based cohort study (2016-2020)

Author

Nacarapa, Edy, primary, Munyangaju, Isabelle, additional, Osório, Dulce, additional, Zindoga, Pereira, additional, Mutaquiha, Claudia, additional, Jose, Benedita, additional, Macuacua, Artur, additional, Chongo, Bartolomeu, additional, de-Almeida, Marcelo, additional, Verdu, Maria-Elisa, additional, and Ramos-Rincon, Jose-Manuel, additional

Published
2022
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35. Frequency and characteristics of HTLV in migrants: results from the +Redivi collaborative network in Spain

Author

Norman, Francesca F, primary, Salvador, Fernando, additional, Gullón, Beatriz, additional, Díaz-Menéndez, Marta, additional, Pérez-Ayala, Ana, additional, Rodriguez-Guardado, Azucena, additional, García-Rodriguez, Magdalena, additional, Henriquez-Camacho, Cesar, additional, Goikoetxea, Josune, additional, Bosch-Nicolau, Pau, additional, de la Calle, Fernando, additional, Ramos-Rincon, Jose-Manuel, additional, Aznar, Maria-Luisa, additional, Peñaranda, María, additional, Calabuig, Eva, additional, Suarez-Garcia, Ines, additional, Pérez-Molina, Jose A, additional, and López-Vélez, Rogelio, additional

Published
2022
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37. Clinical Characteristics and Risk Factors for Mortality in Very Old Patients Hospitalized With COVID-19 in Spain

Author

Ramos-Rincon, Jose-Manuel, Buonaiuto, Verónica, Ricci, Michele, Martín-Carmona, Jesica, Paredes-Ruíz, Diana, Calderón-Moreno, María, Rubio-Rivas, Manel, Beato-Pérez, José-Luis, Arnalich-Fernández, Francisco, Monge-Monge, Daniel, Vargas-Núñez, Juan-Antonio, Acebes-Repiso, Gonzalo, Mendez-Bailon, Manuel, Perales-Fraile, Isabel, García-García, Gema-María, Guisado-Vasco, Pablo, Abdelhady-Kishta, Alaaeldeen, Pascual-Pérez, Maria-de-Los-Reyes, Rodríguez-Fernández-Viagas, Cristina, Montaño-Martínez, Adrián, López-Ruiz, Antonio, Gonzalez-Juarez, Maria-Jesus, Pérez-García, Cristina, Casas-Rojo, José-Manuel, Gómez-Huelgas, Ricardo, and SEMI-COVID-19 Network

Subjects
Male, Aging, medicine.medical_specialty, Age ≥ 80, Pneumonia, Viral, Renal function, 030204 cardiovascular system & hematology, Prognostic factors, Logistic regression, AcademicSubjects/MED00280, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Diabetes mellitus, Internal medicine, Humans, Medicine, Hospital Mortality, 030212 general & internal medicine, Mortality, Risk factor, Retrospective Studies, Aged, 80 and over, SARS-CoV-2, business.industry, COVID-19, Age = 80, Retrospective cohort study, =+80%22">Age >= 80, Prognosis, medicine.disease, Comorbidity, Hospitalization, Ageing, Spain, Cohort, AcademicSubjects/SCI00960, Female, Observational study, Geriatrics and Gerontology, business, Research Article
Abstract

Background Advanced age is a well-known risk factor for poor prognosis in COVID-19. However, few studies have specifically focused on very old inpatients with COVID-19. This study aims to describe the clinical characteristics of very old inpatients with COVID-19 and identify risk factors for in-hospital mortality at admission. Methods We conducted a nationwide, multicenter, retrospective, observational study in patients ≥ 80 years hospitalized with COVID-19 in 150 Spanish hospitals (SEMI-COVID-19) Registry (March 1–May 29, 2020). The primary outcome was in-hospital mortality. A uni- and multivariate logistic regression was performed to assess predictors of mortality at admission. Results A total of 2772 consecutive patients (49.4% men, median age 86.3 years) were analyzed. Rates of atherosclerotic cardiovascular disease, diabetes mellitus, dementia, and Barthel Index < 60 were 30.8%, 25.6%, 30.5%, and 21.0%, respectively. The overall case-fatality rate was 46.9% (n: 1301) and increased with age (80–84 years: 41.6%; 85–90 years: 47.3%; 90–94 years: 52.7%; ≥95 years: 54.2%). After analysis, male sex and moderate-to-severe dependence were independently associated with in-hospital mortality; comorbidities were not predictive. At admission, independent risk factors for death were: oxygen saturation < 90%; temperature ≥ 37.8°C; quick sequential organ failure assessment (qSOFA) score ≥ 2; and unilateral–bilateral infiltrates on chest x-rays. Some analytical findings were independent risk factors for death, including estimated glomerular filtration rate < 45 mL/min/1.73 m2; lactate dehydrogenase ≥ 500 U/L; C-reactive protein ≥ 80 mg/L; neutrophils ≥ 7.5 × 103/μL; lymphocytes < 0.8 × 103/μL; and monocytes < 0.5 × 103/μL. Conclusions This first large, multicenter cohort of very old inpatients with COVID-19 shows that age, male sex, and poor preadmission functional status—not comorbidities—are independently associated with in-hospital mortality. Severe COVID-19 at admission is related to poor prognosis.

Published
2020

38. Additional file 1 of Differences in clinical features and mortality in very old unvaccinated patients (≥ 80 years) hospitalized with COVID-19 during the first and successive waves from the multicenter SEMI-COVID-19 Registry (Spain)

Author

Ramos-Rincon, Jose-Manuel, Cobos-Palacios, Lidia, López-Sampalo, Almudena, Ricci, Michele, Rubio-Rivas, Manel, Nuñez-Rodriguez, Maria-Victoria, Miranda-Godoy, Rodrigo, García-Leoni, Maria-Eugenia, Fernández-Madera-Martínez, Rosa, García-García, Gema-María, Beato-Perez, Jose-Luis, Monge-Monge, Daniel, Asín-Samper, Uxua, Bustamante-Vega, Marta, Rábago-Lorite, Isabel, Freire-Castro, Santiago-Jesús, Miramontes-González, Jose-Pablo, Magallanes-Gamboa, Jeffrey-Oskar, Alcalá-Pedrajas, José-Nicolás, García-Gómez, Miriam, Cano-Llorente, Verónica, Carrasco-Sánchez, Francisco-Javier, Martinez-Carrilero, Jesús, Antón-Santos, Juan-Miguel, and Gómez-Huelgas, Ricardo

Abstract

Additional file 1. List of the SEMI-COVID-19 Network members.

Published
2022
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42. Development and evaluation of a machine learning-based in-hospital COvid-19 Disease Outcome Predictor (CODOP): a multicontinental retrospective study

Author

Klen, Riku, primary, Purohit, Disha, additional, Gomez-Huelgas, Ricardo, additional, Casas-Rojo, Jose Manuel, additional, Anton Santos, Juan Miguel, additional, Nunez-Cortes, Jesus Millan, additional, Lumbreras, Carlos, additional, Ramos-Rincon, Jose Manuel, additional, Young, Pablo, additional, Ramirez, Juan Ignacio, additional, Titto Omonte, Estela Edith, additional, Gross Artega, Rosmery, additional, Canales Beltran, Magdy Teresa, additional, Valdez, Pascual Ruben, additional, Pugliese, Florencia, additional, Castagna, Rosa, additional, Funke, Nico, additional, Leiding, Benjamin, additional, and Gomez-Varela, David, additional

Published
2021
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43. Chagas Disease-Related Mortality in Spain, 1997 to 2018

Author

Ramos-Rincon, Jose-Manuel, primary, Llenas-García, Jara, additional, Pinargote-Celorio, Hector, additional, Sánchez-García, Veronica, additional, Wikman-Jorgensen, Philip, additional, Navarro, Miriam, additional, Gil-Anguita, Concepción, additional, Ramos-Sesma, Violeta, additional, and Torrus-Tendero, Diego, additional

Published
2021
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44. Predictors of attrition among adults in a rural HIV clinic in southern Mozambique: 18-year retrospective study

Author

Nacarapa, Edy, primary, Verdu, M. Elisa, additional, Nacarapa, Joana, additional, Macuacua, Artur, additional, Chongo, Bartolomeu, additional, Osorio, Dulce, additional, Munyangaju, Isabelle, additional, Mugabe, Didier, additional, Paredes, Roger, additional, Chamarro, Ana, additional, Revollo, Boris, additional, Alexandre, Silvio S., additional, Simango, Mulassua, additional, Torrus, Diego, additional, and Ramos-Rincon, Jose-Manuel, additional

Published
2021
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46. Additional file 1 of Time trends in hospital discharges in patients aged 85 years and older in Spain: data from the Spanish National Discharge Database (2000–2015)

Author

Palacios-Fernandez, Sergio, Salcedo, Mario, Gonzalez-Alcaide, Gregorio, and Ramos-Rincon, Jose-Manuel

Abstract

Additional file 1: Supplementary Figure 1. Hospitalization annual trends in people > 85 years old in Spain per 100 global discharges by age group, from 2000 to 2015. Supplementary Figure 2. Annual trends in people > 85 years of the proportion of deaths per age group, from 2000 to 2015. Supplementary Figure 3. Annual trends in people > 85 years of mean length of stay per age group, from 2000 to 2015

Published
2021
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47. Remdesivir in Very Old Patients (≥80 Years) Hospitalized with COVID-19: Real World Data from the SEMI-COVID-19 Registry.

Author

Ramos-Rincon, Jose-Manuel, López-Carmona, María-Dolores, Cobos-Palacios, Lidia, López-Sampalo, Almudena, Rubio-Rivas, Manuel, Martín-Escalante, María-Dolores, de-Cossio-Tejido, Santiago, Taboada-Martínez, María-Luisa, Muiño-Miguez, Antonio, Areses-Manrique, Maria, Martinez-Cilleros, Carmen, Tuñón-de-Almeida, Carlota, Abella-Vázquez, Lucy, Martínez-Gonzalez, Angel-Luís, Díez-García, Luis-Felipe, Ripper, Carlos-Jorge, Asensi, Victor, Martinez-Pascual, Angeles, Guisado-Vasco, Pablo, and Lumbreras-Bermejo, Carlos

Subjects
*OLDER patients, *REMDESIVIR, *COVID-19, *MORTALITY, *DEATH rate
Abstract

(1) Background: Large cohort studies of patients with COVID-19 treated with remdesivir have reported improved clinical outcomes, but data on older patients are scarce. Objective: This work aims to assess the potential benefit of remdesivir in unvaccinated very old patients hospitalized with COVID-19; (2) Methods: This is a retrospective analysis of patients ≥ 80 years hospitalized in Spain between 15 July and 31 December 2020 (SEMI-COVID-19 Registry). Differences in 30-day all-cause mortality were adjusted using a multivariable regression analysis. (3) Results: Of the 4331 patients admitted, 1312 (30.3%) were ≥80 years. Very old patients treated with remdesivir (n: 140, 10.7%) had a lower mortality rate than those not treated with remdesivir (OR (95% CI): 0.45 (0.29–0.69)). After multivariable adjustment by age, sex, and variables associated with lower mortality (place of COVID-19 acquisition; degree of dependence; comorbidities; dementia; duration of symptoms; admission qSOFA; chest X-ray; D-dimer; and treatment with corticosteroids, tocilizumab, beta-lactams, macrolides, and high-flow nasal canula oxygen), the use of remdesivir remained associated with a lower 30-day all-cause mortality rate (adjusted OR (95% CI): 0.40 (0.22–0.61) (p < 0.001)). (4) Conclusions: Remdesivir may reduce mortality in very old patients hospitalized with COVID-19. [ABSTRACT FROM AUTHOR]

Published
2022
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49. Imported cysticercosis in Spain: A retrospective case series from the +REDIVI Collaborative Network

Author

Herrador, Zaida, Perez-Molina, Jose A., Henriquez Camacho, Cesar Augusto, Rodriguez-Guardado, Azucena, Bosch-Nicolau, Pau, Calabuig, Eva, Dominguez-Castellano, Angel, Asuncion Perez-Jacoiste, Maria, Ladron de Guevara, M. Concepcion, Mena, Ana, Manuel Ruiz-Giardin, Jose, Torrus, Diego, Wikman-Jorgensen, Philip, Benito, Agustin, Lopez-Velez, Rogelio, Aguilera, Paloma, Martinez Serrano, Maria, Garcia Rodriguez, Magdalena, Diaz Menendez, Marta, Meije, Yolanda, Martinez-Montauti, Joaquim, Sanz, Xavier, Pacheco Tenza, Isabel, Gonzalez Cuello, Inmaculada, Martinez Lopez, Belen, Llenas-Garcia, Jara, Masia, Mar, Padilla, Sergio, Romero, Monica, Ramos Rincon, Jose Manuel, Suarez, Ines, Perez-Ayala, Ana, Maria Herrero, Juan, Lizasoain, Manuel, Rojo, Pablo, Matarranz, Mariano, Zarco, Carlos, Fernandez Suarez, Jonathan, Boga Ribeiro, Jose Antonio, Goikoetxea Aguirre, Josune, Zubero Sulibarria, Miren Zurine, Sanmartin Lopez, Juan Victor, Velasco Arribas, Maria, Penaranda Vera, Maria, Molina, Israel, Sanchez Montalva, Adrian, Salvador, Fernando, Monge-Maillo, Begona, Norman, Francesca, Chamorro Tojeiro, Sandra, Trevino-Maruri, Begoria, Serre Delcor, Nuria, Soriano-Arandes, Antonio, Pou Ciruelo, Diana, Bocanegra, Cristina, REDIVI Study Grp, Instituto de Salud Carlos III, European Regional Development Fund, Instituto de Salud Carlos III - ISCIII, and European Regional Development Fund (ERDF/FEDER)

Subjects
Adult, Male, medicine.medical_specialty, Pediatrics, 030231 tropical medicine, Neurocysticercosis, Disease, Albendazole, Serology, 03 medical and health sciences, Epilepsy, 0302 clinical medicine, parasitic diseases, Taenia solium, medicine, Travel medicine, Humans, 030212 general & internal medicine, Retrospective Studies, business.industry, Cysticercosis, Public Health, Environmental and Occupational Health, Neglected Diseases, medicine.disease, Europe, medicine.drug_formulation_ingredient, Neglected diseases, Infectious Diseases, Spain, business, Imported infectious diseases, Travel Medicine, medicine.drug
Abstract

Background: Neurocysticercosis (NCC) is the most common parasitic neurological disease worldwide and a major cause of epilepsy. Spain is the country reporting the highest number of NCC imported cases in Europe. Methodology: Retrospective case series of NCC patients registered in the +REDIVI Network from October 1, 2009 to July 2018. A specific questionnaire, including clinical and diagnostic characteristics, was created and sent to the collaborator centers. Results: 46 cases were included in the analysis. 55% were male, mean age of 40 years. 95.6% were migrants. The median duration since migration from an endemic area was 10 years. Predominant nationalities were Ecuadorians (50%) and Bolivians (30.4%). Frequent locations were parenchymal (87%), subarachnoid (26.1%) and intraventricular cysts (10.9%). Serological analysis was performed in 91.3%, being 54.8% positive. Most prevalent clinical manifestations were persistent headache (60.9%), epilepsy (43.5%) and visual changes (13%). Patients were mainly treated with albendazole (76.1%), corticosteroids (67.4%), and anticonvulsionants (52.2%). 82.5% had a favorable clinical outcome. Conclusions: Most NCC cases were long-standing migrants. Few clinical differences were observed depending on the cysticerci location. The treatment was often not according to current recommendations, and no uniform criteria were followed when it came to the therapeutic regimen. NCC case management in Spain (including clinician awareness and laboratory capacity improvements) needs to be strengthened., We would thanks Maria Jesus Perteguer from the National Center of Microbiology for the information and update on NCC lab techniques currently performed in Spain. The corresponding author's affiliation centre belongs to the ISCIII-Sub. Gral. Redes-Network Biomedical Research on Tropical Diseases (RICET in Spanish) grant RD16CIII/0003/0001, RD16/0027/0020, RD16CIII/0003/0001 and the European Regional Development Fund. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Published
2020

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