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3. Pulmonary rehabilitation in sarcoidosis: a systematic review and meta-analysis

Author

Caballeria Lamelas, Estrella, primary, Alsina Restoy, Xavier, additional, Torres Castro, Rodrigo, additional, Gimeno Santos, Elena, additional, Solis Navarro, Lilian, additional, Francesqui, Joel, additional, Hernández González, Fernanda, additional, Ramos Casals, Manel, additional, Blanco, Isabel, additional, and Sellarès, Jacobo, additional

Published
2023
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7. Registry of the Spanish Network for Systemic Sclerosis: Clinical Pattern According to Cutaneous Subsets and Immunological Status

Author

Simeón-Aznar, Carmen Pilar, Fonollosa-Plá, Vicent, Tolosa-Vilella, Carles, Espinosa-Garriga, Gerard, Ramos-Casals, Manel, Campillo-Grau, Mercedes, García-Hernández, Francisco José, Castillo-Palma, María Jesús, Sánchez-Román, Julio, Callejas-Rubio, José Luis, Ortego-Centeno, Norberto, Egurbide-Arberas, Maria Victoria, Trapiellla-Martínez, Luis, Gallego-Villalobos, María, Sáez-Comet, Luis, Velilla-Marco, José, Camps-García, María Teresa, de Ramón-Garrido, Enrique, Esteban Marcos, Eva María, Pallarés-Ferreres, Lucio, Hidalgo-Tenorio, Carmen, Sabio-Sánchez, José Mario, Gómez-de la Torre, Ricardo, Salvador-Cervello, Gonzalo, Rios-Blanco, Juan José, Gil-Aguado, Antonio, and Vilardell-Tarrés, Miquel

Published
2012
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8. Defining disease activity states and clinically meaningful improvement in primary Sjögrenʼs syndrome with EULAR primary Sjögrenʼs syndrome disease activity (ESSDAI) and patient-reported indexes (ESSPRI)

Author

Seror, Raphaèle, Bootsma, Hendrika, Saraux, Alain, Bowman, Simon J, Theander, Elke, Brun, Johan G, Baron, Gabriel, Le Guern, Véronique, Devauchelle-Pensec, Valérie, Ramos-Casals, Manel, Valim, Valeria, Dörner, Thomas, Tzioufas, Athanasios, Gottenberg, Jacques-Eric, Solans Laqué, Roser, Mandl, Thomas, Hachulla, Eric, Sivils, Kathy L, Ng, Wan-Fai, Fauchais, Anne-Laure, Bombardieri, Stefano, Priori, Roberta, Bartoloni, Elena, Goeb, Vincent, Praprotnik, Sonja, Sumida, Takayuki, Nishiyama, Sumusu, Caporali, Roberto, Kruize, Aike A, Vollenweider, Cristina, Ravaud, Philippe, Meiners, Petra, Brito-Zerón, Pilar, Vitali, Claudio, Mariette, Xavier, Gerli, Roberto, Kallenberg, Cees, Brun, Johan G, De Vita, Salvatore, Devauchelle, Valerie, Gottenberg, Jacques Eric, Demoulins, Frederic, Montecucco, Carlomaurizio, Tomsic, Matija, Casals, Manel Ramos, Scofield, Hal, Valesini, Guido, Devauchelle, Valerie, Saraux, Alain, Dubost, Jean-Jacques, Fauchais, Anne-Laure, Sibilia, Jean, Hayem, Gilles, Hatron, Pierre- Yves, Larroche, Claire, Guern, Veronique Le, Puéchal, Xavier, Morel, Jacques, Pedriger, Aleth, Rist, Stephanie, Sene, Damien, and Vittecoq, Olivier

Published
2016
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9. Validation of EULAR primary Sjögrenʼs syndrome disease activity (ESSDAI) and patient indexes (ESSPRI)

Author

Seror, Raphaèle, Theander, Elke, Brun, Johan G, Ramos-Casals, Manel, Valim, Valeria, Dörner, Thomas, Bootsma, Hendrika, Tzioufas, Athanasios, Solans-Laqué, Roser, Mandl, Thomas, Gottenberg, Jacques-Eric, Hachulla, Eric, Sivils, Kathy L, Ng, Wan-Fai, Fauchais, Anne-Laure, Bombardieri, Stefano, Valesini, Guido, Bartoloni, Elena, Saraux, Alain, Tomsic, Matija, Sumida, Takayuki, Nishiyama, Susumu, Caporali, Roberto, Kruize, Aike A, Vollenweider, Cristina, Ravaud, Philippe, Vitali, Claudio, Mariette, Xavier, Bowman, Simon J, Gerli, Roberto, Kallenberg, Cees, Meiners, Petra, De Vita, Salvatore, Devauchelle, Valerie, Demoulins, Frederic, Montecucco, Carlomaurizio, Praprotnik, Sonja, and Scofield, Hal

Published
2015
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11. EULAR Sjögrenʼs Syndrome Patient Reported Index (ESSPRI): development of a consensus patient index for primary Sjögrenʼs syndrome

Author

Seror, Raphaèle, Ravaud, Philippe, Mariette, Xavier, Bootsma, Hendrika, Theander, Elke, Hansen, Arne, Ramos-Casals, Manel, Dörner, Thomas, Bombardieri, Stefano, Hachulla, Eric, Brun, Johan G, Kruize, Aike A, Praprotnik, Sonja, Tomsic, Matija, Gottenberg, Jacques-Eric, Devauchelle, Valerie, Devita, Salvatore, Vollenweider, Cristina, Mandl, Thomas, Tzioufas, Athanasios, Carsons, Steven, Saraux, Alain, Sutcliffe, Nurhan, Vitali, Claudio, and Bowman, Simon J

Published
2011
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13. Influence of epidemiology and ethnicity on systemic expression of primary Sjögren syndrome in 9974 patients

Author

Retamozo, Soledad, Acar-Denizli, Nihan, Fai Ng, W, Zeher, M, Rasmussen, A, Seror, Raphaèle, Li, X, Baldini, C, Gottenberg, Jacques-Eric, Danda, D, Quartuccio, Luca, Priori, R, Hernandez-Molina, G, Armagan, B, Kruize, Aike A, Kwok, S-K, Wahren-Herlenius, Marie, Praprotnik, Sonja, Sene, Damien, Bartoloni, Elena, Solans, R., Rischmueller, Maureen, Mandl, T, Suzuki, Y, Isenberg, David, Valim, V, Wiland, Piotr, Nordmark, Gunnel, Fraile, G, Bootsma, Hendrika, Nakamura, T, Giacomelli, R., Devauchelle-Pensec, Valérie, Hofauer, Benedikt, Bombardieri, Michele, Fernandes Moça Trevisani, Virginia, Hammenfors, D, S.G., Pasoto, Gheita, Tamer A, Atzeni, Fabiola, Morel, Jacques, Vollenveider, Cristina, Brito-Zerón, Pilar, Ramos-Casals, Manel, Rheumatology Unit, Cordoba (Institute University of Biomedical Sciences University of Cordoba (IUCBC), Hospital Clinic (IDIBAPS), INICSA, UNC, CONICED, Cordoba, Mimar Sinan Üniversitesi, Newcastle University [Newcastle], University of Debrecen [Hungary], Oklahoma Medical Research Foundation, Oklahoma Medical Research Foundation (OMRF), Université Paris Sud (Paris 11), Anhui Provincial Hosp, University of Pisa - Università di Pisa, Les Hôpitaux Universitaires de Strasbourg (HUS), Christian Medical College & Hospital, Rheumatology Clinic, Udine (DSMB), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], INCMNSS, Mexico, Hacettepe University = Hacettepe Üniversitesi, University Medical Center [Utrecht], Catholic University of Korea, Unit of Experimental Rheumatology, Stockhom (Department of Medicine), Department of Rheumatology, University Medical Centre, Service de médecine interne [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Università degli Studi di Perugia (UNIPG), Vall d'Hebron University Hospital [Barcelona], The University of Western Australia (UWA), Lund University, Malmö University Hospital, Kanazawa Medical University, Centre for Rheumatology - London, Federal University of Espírito Santo, Wroclaw Medical University, Uppsala Universitet [Uppsala], Hospital Universitario Ramón y Cajal [Madrid], Universidad de Alcalá - University of Alcalá (UAH), Department of Rheumatology and Clinical Immunology Groningen (Dep Rheum - GRONINGEN), University Medical Center Groningen [Groningen] (UMCG), Nagasaki University, University of L'Aquila [Italy] (UNIVAQ), CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Lymphocyte B et Auto-immunité (LBAI), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), Hals-Nasen-Ohrenklinik und Poliklinik, Munchen, Queen Mary University London, Université Fédérale de São Paulo (Unifesp), Haukeland University Hospital, University of Bergen (UiB), Hospital das Clinicas, University of Sao Paulo School of Medicine, Cairo University - Faculty of Medicine, Messina and Milan Univ, Milan, Service de Rhumatologie [CHU de Montpellier], CHU Montpellier, German Hosp, Buenos Aires, H. CIMA-Sanitas, Barcelona, and Michel, Geneviève

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

14. A north-south worldwide gradient in systemic activity of primary Sjögren syndrome: increased severe disease in patients from southern countries

Author

Retamozo, Soledad, Acar-Denizli, Nihan, Fai Ng, W, Zeher, M, Rasmussen, A, Seror, Raphaele, LI, Xiaogai, Baldini, C, Gottenberg, Jacques-Eric, Danda, D, Quartuccio, Luca, Priori, Roberta, Hernandez-Molina, G, Armagan, B, Kruize, Aike A, Kwok, S-K, Wahren-Herlenius, Marie, Praprotnik, Sonja, Sene, D, Bartoloni, Elena, Solans, R., Rischmueller, Maureen, Mandl, T, Suzuki, Y, Isenberg, David A, Valim, V, Wiland, Piotr, Nordmark, Gunnel, Fraile, G, Bootsma, Hendrika, Nakamura, T, Giacomelli, R., Devauchelle-Pensec, Valérie, Hofauer, Benedikt, Bombardieri, Michele, Trevisani, Virginia Fernandes Moça, Hammenfors, D, S.G., Pasoto, Gheita, Tamer A, Atzeni, Fabiola, Morel, J, Vollenveider, Cristina, Ramos-Casals, Manel, Rheumatology Unit, Cordoba (Institute University of Biomedical Sciences University of Cordoba (IUCBC), Hospital Clinic (IDIBAPS), INICSA, UNC, CONICED, Cordoba, Mimar Sinan Üniversitesi, Newcastle University [Newcastle], University of Debrecen [Hungary], Oklahoma Medical Research Foundation, Oklahoma Medical Research Foundation (OMRF), Center for Immunology of Viral Infections and Autoimmune Diseases, Le Kremlin Bicêtre, Anhui Provincial Hosp, University of Pisa - Università di Pisa, Immuno-Rhumatologie Moléculaire, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Christian Medical College & Hospital, Rheumatology Clinic, Udine (DSMB), UO Complessa Reumatologia, Rome, INCMNSS, Mexico, Hacettepe University = Hacettepe Üniversitesi, University Medical Center [Utrecht], Catholic University of Korea, Unit of Experimental Rheumatology, Stockhom (Department of Medicine), Department of Rheumatology, University Medical Centre, Université Paris Diderot - Paris 7 (UPD7), Università degli Studi di Perugia (UNIPG), Vall d'Hebron University Hospital [Barcelona], The University of Western Australia (UWA), Lund University, Malmö University Hospital, Kanazawa Medical University, Centre for Rheumatology - London, Federal University of Espírito Santo, Wroclaw Medical University, Uppsala Universitet [Uppsala], Hospital Universitario Ramón y Cajal [Madrid], Universidad de Alcalá - University of Alcalá (UAH), University of Groningen [Groningen], Nagasaki University, University of L'Aquila [Italy] (UNIVAQ), CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Lymphocyte B et Auto-immunité (LBAI), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), Hals-Nasen-Ohrenklinik und Poliklinik, Munchen, Queen Mary University London, Federal University of Sao Paulo (Unifesp), Haukeland University Hospital, University of Bergen (UIB), Hospital das Clinicas, University of Sao Paulo School of Medicine, Cairo University - Faculty of Medicine, Messina and Milan Univ, Milan, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), German Hosp, Buenos Aires, Laboratory of Autoimmune Diseases Josep Font Barcelona, CELLEX-IDIBAPS Department of Autoimmune Diseases, Barcelona, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Strasbourg (UNISTRA), University of Bergen (UiB), and Michel, Geneviève

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

17. Validation of EULAR primary Sjogren's syndrome disease activity (ESSDAI) and patient indexes (ESSPRI)

Author

Seror, Raphaèle, Theander, Elke, Brun, Johan G, Ramos-Casals, Manel, Valim, Valeria, Dörner, Thomas, Bootsma, Hendrika, Tzioufas, Athanasios, Solans-Laqué, Roser, Mandl, Thomas, Gottenberg, Jacques-Eric, Hachulla, Eric, Sivils, Kathy L, Ng, Wan-Fai, Fauchais, Anne-Laure, Bombardieri, Stefano, Valesini, Guido, Bartoloni, Elena, Saraux, Alain, Tomsic, Matija, Sumida, Takayuki, Nishiyama, Susumu, Caporali, Roberto, Kruize, Aike A, Vollenweider, Cristina, Ravaud, Philippe, Vitali, Claudio, Mariette, Xavier, Bowman, Simon J, EULAR Sjögren's Task Force, Service de rhumatologie, AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Department of Rheumatology, Lund University [Lund], Klinik für Dermatologie, Venerologie und Allergologie, Department of Pathophysiology, Medical School, University of Athens, Immuno-Rhumatologie Moléculaire, Université de Strasbourg ( UNISTRA ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université de Lille, Droit et Santé, University of Northumbria at Newcastle [United Kingdom], Service de Médecine interne A et polyclinique médicale [CHU Limoges], CHU Limoges, Department of Internal Medicine, Lupus Clinic, Sapienza University [Rome], Immunologie et Pathologie ( EA2216 ), Université de Brest ( UBO ) -IFR148, Centre d'Investigation Clinique ( CIC - Brest ), Université de Brest ( UBO ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Faculty of Chemistry and Chemical Technology, University of Ljubjana, University of Tsukuba, Equipe 5 : METHODS - Méthodes de l’évaluation thérapeutique des maladies chroniques ( CRESS - U1153 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité ( CRESS (U1153 / UMR_A 1125) ), Institut National de la Recherche Agronomique ( INRA ) -Université Sorbonne Paris Cité ( USPC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut National de la Recherche Agronomique ( INRA ) -Université Sorbonne Paris Cité ( USPC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Department of Internal Medicine and section of Rheumatology, Villamarina Hospital, Immunologie des Maladies Virales et Autoimmunes ( IMVA - U1184 ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Paris-Sud - Paris 11 ( UP11 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Immunologie et Pathologie (EA2216), Université de Brest (UBO)-IFR148, Centre d'Investigation Clinique (CIC - Brest), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), Equipe 5 : METHODS - Méthodes de l’évaluation thérapeutique des maladies chroniques (CRESS - U1153), Université Paris Descartes - Paris 5 (UPD5)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Immunologie des Maladies Virales et Autoimmunes (IMVA - U1184), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Sorbonne Paris Cité (USPC), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), University of Ljubljana, Université de Tsukuba = University of Tsukuba, Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Strasbourg (UNISTRA), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA), Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), and Translational Immunology Groningen (TRIGR)

Subjects
Male, [SDV]Life Sciences [q-bio], Sjögren's Syndrome, Severity of Illness Index, law.invention, RESPONSIVENESS, Randomized controlled trial, law, EUROPEAN LEAGUE, Immunology and Allergy, Prospective Studies, Disease Activity, Outcomes research, Non-U.S. Gov't, Prospective cohort study, Fatigue, primary Sjögren ’ s syndrome, Research Support, Non-U.S. Gov't, Middle Aged, 3. Good health, Europe, Sjogren's Syndrome, REPORTED INDEX, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Female, Adult, medicine.medical_specialty, Immunology, Pain, Research Support, CONTROLLED-TRIAL, Xerostomia, General Biochemistry, Genetics and Molecular Biology, [ SDV.MHEP.RSOA ] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Rheumatology, Internal medicine, Severity of illness, Xerophthalmia, medicine, Journal Article, Humans, Validation Studies, RITUXIMAB, Aged, [ SDV ] Life Sciences [q-bio], business.industry, Gold standard, Construct validity, Reproducibility of Results, HEALTH-STATUS INSTRUMENTS, medicine.disease, Physical therapy, Self Report, business, Rheumatism
Abstract

Objectives To validate the two recently developed disease activity indexes for assessment of primary Sjogren's syndrome (SS): the European League Against Rheumatism (EULAR) SS Patient Reported Index (ESSPRI) and the EULAR SS Disease Activity Index (ESSDAI).Methods A prospective international 6-month duration validation study was conducted in 15 countries. At each visit, physicians completed ESSDAI, SS disease activity index (SSDAI), Sjogren's Systemic Clinical Activity Index (SCAI) and physician global assessment (PhGA); and patients completed ESSPRI, Sicca Symptoms Inventory (SSI), Profile of Fatigue and Discomfort (PROFAD) and patient global assessment (PGA). Psychometric properties (construct validity, responsiveness and reliability) were evaluated and compared between scores.Results Of the 395 patients included, 145 (37%) and 251 (64%) had currently active or current or past systemic manifestations, respectively. EULAR scores had higher correlation with the gold standard than other scores (ESSDAI with PhGA: r= 0.59; ESSRPI with PGA: r= 0.70). Correlations between patient and systemic scores were very low (ranging from 0.07 to 0.29). All systemic scores had similar large responsiveness in improved patients. Responsiveness of patient scores was low but was significantly higher for ESSPRI compared with SSI and PROFAD. Reliability was very good for all scores.Conclusions ESSDAI and ESSPRI had good construct validity. All scores were reliable. Systemic scores had a large sensitivity to change in patients whose disease activity improves. Patient scores had a small sensitivity to change, however, significantly better for ESSPRI. Systemic and patient scores poorly correlated, suggesting that they are 2 complementary components that should be both evaluated, but separately.

Published
2014
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19. Development of the ClinESSDAI : a clinical score without biological domain. A tool for biological studies

Author

Seror, Raphaèle, Meiners, Petra, Baron, Gabriel, Bootsma, Hendrika, Bowman, Simon J, Vitali, Claudio, Gottenberg, Jacques-Eric, Theander, Elke, Tzioufas, Athanasios, De Vita, Salvatore, Ramos-Casals, Manel, Dörner, Thomas, Quartuccio, Luca, Ravaud, Philippe, Mariette, Xavier, and EULAR Sjögren Task Force

Subjects
Journal Article, Validation Studies
Abstract

OBJECTIVE: To develop and validate ClinESSDAI (Clinical European League Against Rheumatism Sjögren's Syndrome Disease Activity Index), ie, ESSDAI without the biological domain. PATIENTS AND METHODS: The 702 fictive vignettes derived from 96 real cases of primary Sjögren's syndrome of the ESSDAI development study were used. As for ESSDAI development, the physician assessment of disease activity (0-10 scale) was used as the 'gold standard' in a multivariate model for weighting domains, after removing the biological domain. The reliability, assessed by intraclass correlation coefficient (ICC) between ClinESSDAI and ESSDAI, explored if ClinESSDAI was equivalent to ESSDAI. Its psychometric (ie, measurement) properties were compared with that of ESSDAI in an independent cohort. Also, its use was evaluated on data of two clinical trials. RESULTS: In multivariate modelling, all 11 domains remained significantly associated with disease activity, with slight modifications of some domain weights. Reliability between clinESSDAI and ESSDAI was excellent (ICC=0.98 and 0.99). Psychometric properties of clinESSDAI, disease activity levels and minimal clinically important improvement thresholds and its ability to detect change over time in clinical trials were very close to that of ESSDAI. CONCLUSIONS: ClinESSDAI appears valid and very close to the original ESSDAI. This score provides an accurate evaluation of disease activity independent of B-cell biomarkers. It could be used in various circumstances: (i) in biological/clinical studies to avoid data collinearity, (ii) in clinical trials, as secondary endpoint, to detect change independent of biological effect of the drug, (iii) in clinical practice to assess disease activity for visits where immunological tests have not been done.

Published
2016

20. Development of the ClinESSDAI: a clinical score without biological domain. A tool for biological studies

Author

MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Seror, Raphaèle, Meiners, Petra, Baron, Gabriel, Bootsma, Hendrika, Bowman, Simon J, Vitali, Claudio, Gottenberg, Jacques-Eric, Theander, Elke, Tzioufas, Athanasios, De Vita, Salvatore, Ramos-Casals, Manel, Dörner, Thomas, Quartuccio, Luca, Ravaud, Philippe, Mariette, Xavier, EULAR Sjögren Task Force, MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Seror, Raphaèle, Meiners, Petra, Baron, Gabriel, Bootsma, Hendrika, Bowman, Simon J, Vitali, Claudio, Gottenberg, Jacques-Eric, Theander, Elke, Tzioufas, Athanasios, De Vita, Salvatore, Ramos-Casals, Manel, Dörner, Thomas, Quartuccio, Luca, Ravaud, Philippe, Mariette, Xavier, and EULAR Sjögren Task Force

Published
2016

21. Defining disease activity states and clinically meaningful improvement in primary Sjögren's syndrome with EULAR primary Sjögren's syndrome disease activity (ESSDAI) and patient-reported indexes (ESSPRI)

Author

MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Seror, Raphaèle, Bootsma, Hendrika, Saraux, Alain, Bowman, Simon J, Theander, Elke, Brun, Johan G, Baron, Gabriel, Le Guern, Véronique, Devauchelle-Pensec, Valérie, Ramos-Casals, Manel, Valim, Valeria, Dörner, Thomas, Tzioufas, Athanasios, Gottenberg, Jacques-Eric, Solans Laqué, Roser, Mandl, Thomas, Hachulla, Eric, Sivils, Kathy L, Ng, Wan-Fai, Fauchais, Anne-Laure, Bombardieri, Stefano, Priori, Roberta, Bartoloni, Elena, Goeb, Vincent, Praprotnik, Sonja, Sumida, Takayuki, Nishiyama, Sumusu, Caporali, Roberto, Kruize, Aike A, Vollenweider, Cristina, Ravaud, Philippe, Meiners, Petra, Brito-Zerón, Pilar, Vitali, Claudio, Mariette, Xavier, EULAR Sjögren's Task Force, MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Seror, Raphaèle, Bootsma, Hendrika, Saraux, Alain, Bowman, Simon J, Theander, Elke, Brun, Johan G, Baron, Gabriel, Le Guern, Véronique, Devauchelle-Pensec, Valérie, Ramos-Casals, Manel, Valim, Valeria, Dörner, Thomas, Tzioufas, Athanasios, Gottenberg, Jacques-Eric, Solans Laqué, Roser, Mandl, Thomas, Hachulla, Eric, Sivils, Kathy L, Ng, Wan-Fai, Fauchais, Anne-Laure, Bombardieri, Stefano, Priori, Roberta, Bartoloni, Elena, Goeb, Vincent, Praprotnik, Sonja, Sumida, Takayuki, Nishiyama, Sumusu, Caporali, Roberto, Kruize, Aike A, Vollenweider, Cristina, Ravaud, Philippe, Meiners, Petra, Brito-Zerón, Pilar, Vitali, Claudio, Mariette, Xavier, and EULAR Sjögren's Task Force

Published
2016

22. Development of the ClinESSDAI: a clinical score without biological domain. A tool for biological studies

Author

Seror, Raphaèle, primary, Meiners, Petra, additional, Baron, Gabriel, additional, Bootsma, Hendrika, additional, Bowman, Simon J, additional, Vitali, Claudio, additional, Gottenberg, Jacques-Eric, additional, Theander, Elke, additional, Tzioufas, Athanasios, additional, De Vita, Salvatore, additional, Ramos-Casals, Manel, additional, Dörner, Thomas, additional, Quartuccio, Luca, additional, Ravaud, Philippe, additional, and Mariette, Xavier, additional

Published
2016
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23. EULAR Sjögren's syndrome disease activity index (ESSDAI) : a user guide

Author

Seror, Raphaèle, Bowman, Simon J, Brito-Zeron, Pilar, Theander, Elke, Bootsma, Hendrika, Tzioufas, Athanasios, Gottenberg, Jacques-Eric, Ramos-Casals, Manel, Dörner, Thomas, Ravaud, Philippe, Vitali, Claudio, Mariette, Xavier, Asmussen, Karsten, Jacobsen, Soren, Bartoloni, Elena, Gerli, Roberto, Bijlsma, Johannes Wj, Kruize, Aike A, Bombardieri, Stefano, Bookman, Arthur, Kallenberg, Cees, Meiners, Petra, Brun, Johan G, Jonsson, Roland, Caporali, Roberto, Carsons, Steven, De Vita, Salvatore, Del Papa, Nicoletta, Devauchelle, Valerie, Saraux, Alain, Fauchais, Anne-Laure, Sibilia, Jean, Hachulla, Eric, Illei, Gabor, Isenberg, David, Jones, Adrian, Manoussakis, Menelaos, Mandl, Thomas, Jacobsson, Lennart, Demoulins, Frederic, Montecucco, Carlomaurizio, Ng, Wan-Fai, Nishiyama, Sumusu, Omdal, Roald, Parke, Ann, Praprotnik, Sonja, Tomsic, Matjia, Price, Elizabeth, Scofield, Hal, L Sivils, Kathy, Smolen, Josef, Laqué, Roser Solans, Steinfeld, Serge, Sutcliffe, Nurhan, Sumida, Takayuki, Valesini, Guido, Valim, Valeria, Vivino, Frederick B, Vollenweider, Cristina, Seror, Raphaèle, Bowman, Simon J, Brito-Zeron, Pilar, Theander, Elke, Bootsma, Hendrika, Tzioufas, Athanasios, Gottenberg, Jacques-Eric, Ramos-Casals, Manel, Dörner, Thomas, Ravaud, Philippe, Vitali, Claudio, Mariette, Xavier, Asmussen, Karsten, Jacobsen, Soren, Bartoloni, Elena, Gerli, Roberto, Bijlsma, Johannes Wj, Kruize, Aike A, Bombardieri, Stefano, Bookman, Arthur, Kallenberg, Cees, Meiners, Petra, Brun, Johan G, Jonsson, Roland, Caporali, Roberto, Carsons, Steven, De Vita, Salvatore, Del Papa, Nicoletta, Devauchelle, Valerie, Saraux, Alain, Fauchais, Anne-Laure, Sibilia, Jean, Hachulla, Eric, Illei, Gabor, Isenberg, David, Jones, Adrian, Manoussakis, Menelaos, Mandl, Thomas, Jacobsson, Lennart, Demoulins, Frederic, Montecucco, Carlomaurizio, Ng, Wan-Fai, Nishiyama, Sumusu, Omdal, Roald, Parke, Ann, Praprotnik, Sonja, Tomsic, Matjia, Price, Elizabeth, Scofield, Hal, L Sivils, Kathy, Smolen, Josef, Laqué, Roser Solans, Steinfeld, Serge, Sutcliffe, Nurhan, Sumida, Takayuki, Valesini, Guido, Valim, Valeria, Vivino, Frederick B, and Vollenweider, Cristina

Published
2015

24. EULAR Sjögren's syndrome disease activity index (ESSDAI): a user guide

Author

MS Reumatologie/Immunologie/Infectie, Regenerative Medicine and Stem Cells, Infection & Immunity, Seror, Raphaèle, Bowman, Simon J, Brito-Zeron, Pilar, Theander, Elke, Bootsma, Hendrika, Tzioufas, Athanasios, Gottenberg, Jacques-Eric, Ramos-Casals, Manel, Dörner, Thomas, Ravaud, Philippe, Vitali, Claudio, Mariette, Xavier, Asmussen, Karsten, Jacobsen, Soren, Bartoloni, Elena, Gerli, Roberto, Bijlsma, Johannes Wj, Kruize, Aike A, Bombardieri, Stefano, Bookman, Arthur, Kallenberg, Cees, Meiners, Petra, Brun, Johan G, Jonsson, Roland, Caporali, Roberto, Carsons, Steven, De Vita, Salvatore, Del Papa, Nicoletta, Devauchelle, Valerie, Saraux, Alain, Fauchais, Anne-Laure, Sibilia, Jean, Hachulla, Eric, Illei, Gabor, Isenberg, David, Jones, Adrian, Manoussakis, Menelaos, Mandl, Thomas, Jacobsson, Lennart, Demoulins, Frederic, Montecucco, Carlomaurizio, Ng, Wan-Fai, Nishiyama, Sumusu, Omdal, Roald, Parke, Ann, Praprotnik, Sonja, Tomsic, Matjia, Price, Elizabeth, Scofield, Hal, L Sivils, Kathy, Smolen, Josef, Laqué, Roser Solans, Steinfeld, Serge, Sutcliffe, Nurhan, Sumida, Takayuki, Valesini, Guido, Valim, Valeria, Vivino, Frederick B, Vollenweider, Cristina, MS Reumatologie/Immunologie/Infectie, Regenerative Medicine and Stem Cells, Infection & Immunity, Seror, Raphaèle, Bowman, Simon J, Brito-Zeron, Pilar, Theander, Elke, Bootsma, Hendrika, Tzioufas, Athanasios, Gottenberg, Jacques-Eric, Ramos-Casals, Manel, Dörner, Thomas, Ravaud, Philippe, Vitali, Claudio, Mariette, Xavier, Asmussen, Karsten, Jacobsen, Soren, Bartoloni, Elena, Gerli, Roberto, Bijlsma, Johannes Wj, Kruize, Aike A, Bombardieri, Stefano, Bookman, Arthur, Kallenberg, Cees, Meiners, Petra, Brun, Johan G, Jonsson, Roland, Caporali, Roberto, Carsons, Steven, De Vita, Salvatore, Del Papa, Nicoletta, Devauchelle, Valerie, Saraux, Alain, Fauchais, Anne-Laure, Sibilia, Jean, Hachulla, Eric, Illei, Gabor, Isenberg, David, Jones, Adrian, Manoussakis, Menelaos, Mandl, Thomas, Jacobsson, Lennart, Demoulins, Frederic, Montecucco, Carlomaurizio, Ng, Wan-Fai, Nishiyama, Sumusu, Omdal, Roald, Parke, Ann, Praprotnik, Sonja, Tomsic, Matjia, Price, Elizabeth, Scofield, Hal, L Sivils, Kathy, Smolen, Josef, Laqué, Roser Solans, Steinfeld, Serge, Sutcliffe, Nurhan, Sumida, Takayuki, Valesini, Guido, Valim, Valeria, Vivino, Frederick B, and Vollenweider, Cristina

Published
2015

25. Validation of EULAR primary Sjögren's syndrome disease activity (ESSDAI) and patient indexes (ESSPRI)

Author

MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Seror, Raphaèle, Theander, Elke, Brun, Johan G, Ramos-Casals, Manel, Valim, Valeria, Dörner, Thomas, Bootsma, Hendrika, Tzioufas, Athanasios, Solans-Laqué, Roser, Mandl, Thomas, Gottenberg, Jacques-Eric, Hachulla, Eric, Sivils, Kathy L, Ng, Wan-Fai, Fauchais, Anne-Laure, Bombardieri, Stefano, Valesini, Guido, Bartoloni, Elena, Saraux, Alain, Tomsic, Matija, Sumida, Takayuki, Nishiyama, Susumu, Caporali, Roberto, Kruize, Aike A, Vollenweider, Cristina, Ravaud, Philippe, Vitali, Claudio, Mariette, Xavier, Bowman, Simon J, EULAR Sjögren's Task Force, MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Seror, Raphaèle, Theander, Elke, Brun, Johan G, Ramos-Casals, Manel, Valim, Valeria, Dörner, Thomas, Bootsma, Hendrika, Tzioufas, Athanasios, Solans-Laqué, Roser, Mandl, Thomas, Gottenberg, Jacques-Eric, Hachulla, Eric, Sivils, Kathy L, Ng, Wan-Fai, Fauchais, Anne-Laure, Bombardieri, Stefano, Valesini, Guido, Bartoloni, Elena, Saraux, Alain, Tomsic, Matija, Sumida, Takayuki, Nishiyama, Susumu, Caporali, Roberto, Kruize, Aike A, Vollenweider, Cristina, Ravaud, Philippe, Vitali, Claudio, Mariette, Xavier, Bowman, Simon J, and EULAR Sjögren's Task Force

Published
2015

26. EULAR Sjögren's syndrome disease activity index (ESSDAI):a user guide

Author

Seror, Raphaèle, Bowman, Simon J, Brito-Zeron, Pilar, Theander, Elke, Bootsma, Hendrika, Tzioufas, Athanasios, Gottenberg, Jacques-Eric, Ramos-Casals, Manel, Dörner, Thomas, Ravaud, Philippe, Vitali, Claudio, Mariette, Xavier, Asmussen, Karsten, Jacobsen, Soren, Bartoloni, Elena, Gerli, Roberto, Bijlsma, Johannes Wj, Kruize, Aike A, Bombardieri, Stefano, Bookman, Arthur, Kallenberg, Cees, Meiners, Petra, Brun, Johan G, Jonsson, Roland, Caporali, Roberto, Carsons, Steven, De Vita, Salvatore, Del Papa, Nicoletta, Devauchelle, Valerie, Saraux, Alain, Fauchais, Anne-Laure, Sibilia, Jean, Hachulla, Eric, Illei, Gabor, Isenberg, David, Jones, Adrian, Manoussakis, Menelaos, Mandl, Thomas, Jacobsson, Lennart, Demoulins, Frederic, Montecucco, Carlomaurizio, Ng, Wan-Fai, Nishiyama, Sumusu, Omdal, Roald, Parke, Ann, Praprotnik, Sonja, Tomsic, Matjia, Price, Elizabeth, Scofield, Hal, L Sivils, Kathy, Smolen, Josef, Laqué, Roser Solans, Steinfeld, Serge, Sutcliffe, Nurhan, Sumida, Takayuki, Valesini, Guido, Valim, Valeria, Vivino, Frederick B, Vollenweider, Cristina, Seror, Raphaèle, Bowman, Simon J, Brito-Zeron, Pilar, Theander, Elke, Bootsma, Hendrika, Tzioufas, Athanasios, Gottenberg, Jacques-Eric, Ramos-Casals, Manel, Dörner, Thomas, Ravaud, Philippe, Vitali, Claudio, Mariette, Xavier, Asmussen, Karsten, Jacobsen, Soren, Bartoloni, Elena, Gerli, Roberto, Bijlsma, Johannes Wj, Kruize, Aike A, Bombardieri, Stefano, Bookman, Arthur, Kallenberg, Cees, Meiners, Petra, Brun, Johan G, Jonsson, Roland, Caporali, Roberto, Carsons, Steven, De Vita, Salvatore, Del Papa, Nicoletta, Devauchelle, Valerie, Saraux, Alain, Fauchais, Anne-Laure, Sibilia, Jean, Hachulla, Eric, Illei, Gabor, Isenberg, David, Jones, Adrian, Manoussakis, Menelaos, Mandl, Thomas, Jacobsson, Lennart, Demoulins, Frederic, Montecucco, Carlomaurizio, Ng, Wan-Fai, Nishiyama, Sumusu, Omdal, Roald, Parke, Ann, Praprotnik, Sonja, Tomsic, Matjia, Price, Elizabeth, Scofield, Hal, L Sivils, Kathy, Smolen, Josef, Laqué, Roser Solans, Steinfeld, Serge, Sutcliffe, Nurhan, Sumida, Takayuki, Valesini, Guido, Valim, Valeria, Vivino, Frederick B, and Vollenweider, Cristina

Abstract

The EULAR Sjögren's syndrome (SS) disease activity index (ESSDAI) is a systemic disease activity index that was designed to measure disease activity in patients with primary SS. With the growing use of the ESSDAI, some domains appear to be more challenging to rate than others. The ESSDAI is now in use as a gold standard to measure disease activity in clinical studies, and as an outcome measure, even a primary outcome measure, in current randomised clinical trials. Therefore, ensuring an accurate and reproducible rating of each domain, by providing a more detailed definition of each domain, has emerged as an urgent need. The purpose of the present article is to provide a user guide for the ESSDAI. This guide provides definitions and precisions on the rating of each domain. It also includes some minor improvement of the score to integrate advance in knowledge of disease manifestations. This user guide may help clinicians to use the ESSDAI, and increase the reliability of rating and consequently of the ability to detect true changes over time. This better appraisal of ESSDAI items, along with the recent definition of disease activity levels and minimal clinically important change, will improve the assessment of patients with primary SS and facilitate the demonstration of effectiveness of treatment for patients with primary SS.

Published
2015

27. Defining disease activity states and clinically meaningful improvement in primary Sjögren's syndrome with EULAR primary Sjögren's syndrome disease activity (ESSDAI) and patient-reported indexes (ESSPRI)

Author

Seror, Raphaèle, primary, Bootsma, Hendrika, additional, Saraux, Alain, additional, Bowman, Simon J, additional, Theander, Elke, additional, Brun, Johan G, additional, Baron, Gabriel, additional, Le Guern, Véronique, additional, Devauchelle-Pensec, Valérie, additional, Ramos-Casals, Manel, additional, Valim, Valeria, additional, Dörner, Thomas, additional, Tzioufas, Athanasios, additional, Gottenberg, Jacques-Eric, additional, Solans Laqué, Roser, additional, Mandl, Thomas, additional, Hachulla, Eric, additional, Sivils, Kathy L, additional, Ng, Wan-Fai, additional, Fauchais, Anne-Laure, additional, Bombardieri, Stefano, additional, Priori, Roberta, additional, Bartoloni, Elena, additional, Goeb, Vincent, additional, Praprotnik, Sonja, additional, Sumida, Takayuki, additional, Nishiyama, Sumusu, additional, Caporali, Roberto, additional, Kruize, Aike A, additional, Vollenweider, Cristina, additional, Ravaud, Philippe, additional, Meiners, Petra, additional, Brito-Zerón, Pilar, additional, Vitali, Claudio, additional, and Mariette, Xavier, additional

Published
2014
Full Text
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28. Transgenic Expression of Soluble Human CD5 Enhances Experimentally-Induced Autoimmune and Anti-Tumoral Immune Responses

Author

Fenutría, Rafael, primary, Martinez, Vanesa G., additional, Simões, Inês, additional, Postigo, Jorge, additional, Gil, Victor, additional, Martínez-Florensa, Mario, additional, Sintes, Jordi, additional, Naves, Rodrigo, additional, Cashman, Kevin S., additional, Alberola-Ila, José, additional, Ramos-Casals, Manel, additional, Soldevila, Gloria, additional, Raman, Chander, additional, Merino, Jesús, additional, Merino, Ramón, additional, Engel, Pablo, additional, and Lozano, Francisco, additional

Published
2014
Full Text
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32. Economic Evaluation of Lupus Nephritis in an International Inception Cohort: Comparing the Hospitalization, Medication, Dialysis, and Procedure Costs of Those with and without Nephritis

Author

Barber, Megan, Hanly, John G., O Keeffe, Aidan, Su, Li, Urowitz, Murray, St Pierre, Yvan, Romero-Diaz, Juanita, Gordon, C., Bae, Sang-Cheol, Bernatsky, Sasha, Wallace, Daniel J., Merrill, Joan T., Isenberg, David A., Rahman, Anisur, Ginzler, Ellen M., Fortin, Paul R., Gladman, Dafna D., Sanchez-Guerrero, Jorge, Petri, Michelle, Bruce, Ian N., Dooley, Mary Anne, Ramsey-Goldman, Rosalind, Aranow, Cynthia, Alarcon, Graciela S., Chatham, W. Winn, Steinsson, Kristjan, Nived, Ola, Sturfelt, Gunnar K., Manzi, Susan, Khamashta, Munther, Vollenhoven, Ronald F., Zoma, Asad, Ramos-Casals, Manel, Guillermo Ruiz-Irastorza, Lim, S. Sam, Stoll, Thomas, Inanc, Murat, Kalunian, Kenneth C., Kamen, Diane L., Maddison, Peter, Peschken, Christine A., Jacobsen, Soren, Askanase, Anca, Buyon, Jill P., Theriault, Chris, Thompson, Kara, Farewell, Vernon, and Clarke, Ann E.

33. EULAR Sjögren's syndrome disease activity index (ESSDAI): a user guide.

Author

Seror R, Bowman SJ, Brito-Zeron P, Theander E, Bootsma H, Tzioufas A, Gottenberg JE, Ramos-Casals M, Dörner T, Ravaud P, Vitali C, Mariette X, Asmussen K, Jacobsen S, Bartoloni E, Gerli R, Bijlsma JW, Kruize AA, Bombardieri S, Bookman A, Kallenberg C, Meiners P, Brun JG, Jonsson R, Caporali R, Carsons S, De Vita S, Del Papa N, Devauchelle V, Saraux A, Fauchais AL, Sibilia J, Hachulla E, Illei G, Isenberg D, Jones A, Manoussakis M, Mandl T, Jacobsson L, Demoulins F, Montecucco C, Ng WF, Nishiyama S, Omdal R, Parke A, Praprotnik S, Tomsic M, Price E, Scofield H, L Sivils K, Smolen J, Laqué RS, Steinfeld S, Sutcliffe N, Sumida T, Valesini G, Valim V, Vivino FB, and Vollenweider C

Abstract

The EULAR Sjögren's syndrome (SS) disease activity index (ESSDAI) is a systemic disease activity index that was designed to measure disease activity in patients with primary SS. With the growing use of the ESSDAI, some domains appear to be more challenging to rate than others. The ESSDAI is now in use as a gold standard to measure disease activity in clinical studies, and as an outcome measure, even a primary outcome measure, in current randomised clinical trials. Therefore, ensuring an accurate and reproducible rating of each domain, by providing a more detailed definition of each domain, has emerged as an urgent need. The purpose of the present article is to provide a user guide for the ESSDAI. This guide provides definitions and precisions on the rating of each domain. It also includes some minor improvement of the score to integrate advance in knowledge of disease manifestations. This user guide may help clinicians to use the ESSDAI, and increase the reliability of rating and consequently of the ability to detect true changes over time. This better appraisal of ESSDAI items, along with the recent definition of disease activity levels and minimal clinically important change, will improve the assessment of patients with primary SS and facilitate the demonstration of effectiveness of treatment for patients with primary SS.

Published
2015
Full Text
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34. [Biologic therapy in idiopathic inflammatory myopathy].

Author

Selva-O'Callaghan A, Ramos Casals M, and Grau Junyent JM

Subjects
Antibodies, Monoclonal therapeutic use, Antibodies, Monoclonal, Humanized therapeutic use, Antigens, CD20, Clinical Trials as Topic methods, Clinical Trials as Topic standards, Double-Blind Method, Evidence-Based Medicine, Humans, Internal Medicine, Molecular Targeted Therapy, Multicenter Studies as Topic, Randomized Controlled Trials as Topic methods, Societies, Medical, Spain, Treatment Outcome, Tumor Necrosis Factor-alpha antagonists & inhibitors, Biological Therapy, Myositis therapy
Abstract

The aim of this article is to study the evidence-based knowledge related to the use of biological therapies in patients diagnosed with idiopathic inflammatory myopathy (dermatomyositis, polymyositis and inclusion body myositis). In this review the leading published studies related to the use of biological therapy in patients with myositis are analysed; mainly those with high methodological standards, that means randomized and controlled studies. Methodological drawbacks due to the rarity and heterogeneity of these complex diseases are also addressed. Up to now is not possible to ascertain the biologics as a recommended therapy in patients with myositis, at least based in the current evidence-based knowledge, although it can not be neglected as a therapeutic option in some clinical situations, taking into account the scarce of effective treatments in those patients, especially in refractory myositis. Future studies probably will help to better define the role of biological therapies in patients with idiopathic inflammatory myopathy., (Copyright © 2013 Elsevier España, S.L.U. All rights reserved.)

Published
2014
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