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Introduction: Sickle cell anemia due to recent scientific evidence suggests that individuals with disease are considered a risk group and SARS-CoV-2 and spreads rapidly in this group of patients with diseases due to lack of inherited immunity, has a high lethality rate among young people and children and patients with associated comorbidities such as Diabetes Mellitus. Objective: to analyze the profile of patients with sickle cell anemia and their immunological motivations for worsening in positive cases of COVID-19 from a systematic review. Results: Initially, 217 articles were identified, of which 213 were removed because they were not related to the theme of the review, or because they were duplicated or did not have the abstract. The 04 selected articles were classified into two thematic axes to be performed the analysis. Discussion:  This systematic review study is the first with sickle cell anemia and COVID-19 in the adolescent population with a limited resource configuration that shows the inherent need in the management of both diseases. However, in this systematic review, the four included studies showed a favorable evolution of the infectious process by COVID-19, and deaths occurred in adolescent patients who concomitantly had multiple comorbidities, for example, DM. Conclusion: It was found in this systematic review study that COVID-19 infection may accentuate the presence of vasculopathy in patients with sickle cell anemia and may increase pain to varying degrees.

Health in Brazil through technological innovations, whether under conditions of equipment availability has been using new techniques of care and care in primary care in diseases communicable with tuberculosis. The aim of this study was to evaluate the national and international scientific production on the knowledge about the process of monitoring tuberculosis patients in Brazilian primary care by software applied by a health professional. The methodology used in this study was the systematic review with a critical analysis in the elaboration for a software and was developed in six stages. As a result, 03 articles were obtained for the construction of this systematic review and the critical analysis in the follow-up of tuberculosis patients in primary care in Brazil. Among the models used, it was noticed that the cascading model, linear or classic and prototyping were the most used for software for care support and educational software.

Viral diseases continue to emerge and annually bring challenges to the Brazilian public health system, such as COVID-19 with easy respiratory infection. This study aims to analyze the importance of new technologies in the treatment of COVID-19 and, thus, promote the information of technological data in the Brazilian territory. Therefore, methodological techniques were used in systematic reviews in the selection of included studies to be used in the construction of this short and critical systematic review. And 08 articles were included for inclusion in this critical analysis.

Goals: To verify whether the use of Vitamin D as parallel therapy to hospital and drug treatment can be effective in the process of infectious reduction in hospitalized children. Data source: This study is a systematic review and meta-analysis of randomized controlled trials, published between 2011 and the first quarter of 2019, in the Cochrane Library, Medline, US National Library of Medicine and the National Institute of Health (PubMed), Literature databases. Latin American and Caribbean Health Sciences (Lilacs), Scopus and Web of Science. The studies were scored by the Down and Black scale associated with the quality assessment method according to the Cochrane criteria (RCT). Summary of the data: Of the 1475 studies, 09 were included. There is a direct relationship between Vitamin D level and mortality rate in hospitalized children with infections. Conclusion: This study highlighted that the vitamin D deficiency in children under serum analysis during hospitalization triggers severe immunological changes.

Viruses will continue to emerge and bring challenges to the global public health system with emerging viruses through respiratory contagion that cause pandemics. This study aims to propose a way to use constant monitoring during the period of treatment of the patient with COVID-19 and, thus, reduce the negative indicators of death in the Brazilian territory. Methodological techniques were used in meta-analysis and systematic reviews in the selection of included studies when used in the construction of this systematic review. 05 articles were selected for inclusion in this critical analysis.