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1. Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations.

Author

Pugh, Trevor J, Weeraratne, Shyamal Dilhan, Archer, Tenley C, Pomeranz Krummel, Daniel A, Auclair, Daniel, Bochicchio, James, Carneiro, Mauricio O, Carter, Scott L, Cibulskis, Kristian, Erlich, Rachel L, Greulich, Heidi, Lawrence, Michael S, Lennon, Niall J, McKenna, Aaron, Meldrim, James, Ramos, Alex H, Ross, Michael G, Russ, Carsten, Shefler, Erica, Sivachenko, Andrey, Sogoloff, Brian, Stojanov, Petar, Tamayo, Pablo, Mesirov, Jill P, Amani, Vladimir, Teider, Natalia, Sengupta, Soma, Francois, Jessica Pierre, Northcott, Paul A, Taylor, Michael D, Yu, Furong, Crabtree, Gerald R, Kautzman, Amanda G, Gabriel, Stacey B, Getz, Gad, Jäger, Natalie, Jones, David TW, Lichter, Peter, Pfister, Stefan M, Roberts, Thomas M, Meyerson, Matthew, Pomeroy, Scott L, and Cho, Yoon-Jae

Subjects
Humans, Medulloblastoma, Cerebellar Neoplasms, DNA Helicases, Histone-Lysine N-Methyltransferase, Intracellular Signaling Peptides and Proteins, DNA-Binding Proteins, Receptors, Cell Surface, Neoplasm Proteins, Proto-Oncogene Proteins, Nuclear Proteins, Transcription Factors, Repressor Proteins, Signal Transduction, Protein Structure, Tertiary, Mutation, Genome, Human, Models, Molecular, Child, Tumor Suppressor Protein p53, Wnt Proteins, beta Catenin, TCF Transcription Factors, Hedgehog Proteins, DEAD-box RNA Helicases, Promoter Regions, Genetic, LIM Domain Proteins, Exome, Patched Receptors, Patched-1 Receptor, Histone Methyltransferases, Brain Disorders, Pediatric Cancer, Cancer, Human Genome, Biotechnology, Pediatric, Brain Cancer, Rare Diseases, Genetics, Neurosciences, Genetic Testing, Aetiology, 2.1 Biological and endogenous factors, General Science & Technology
Abstract

Medulloblastomas are the most common malignant brain tumours in children. Identifying and understanding the genetic events that drive these tumours is critical for the development of more effective diagnostic, prognostic and therapeutic strategies. Recently, our group and others described distinct molecular subtypes of medulloblastoma on the basis of transcriptional and copy number profiles. Here we use whole-exome hybrid capture and deep sequencing to identify somatic mutations across the coding regions of 92 primary medulloblastoma/normal pairs. Overall, medulloblastomas have low mutation rates consistent with other paediatric tumours, with a median of 0.35 non-silent mutations per megabase. We identified twelve genes mutated at statistically significant frequencies, including previously known mutated genes in medulloblastoma such as CTNNB1, PTCH1, MLL2, SMARCA4 and TP53. Recurrent somatic mutations were newly identified in an RNA helicase gene, DDX3X, often concurrent with CTNNB1 mutations, and in the nuclear co-repressor (N-CoR) complex genes GPS2, BCOR and LDB1. We show that mutant DDX3X potentiates transactivation of a TCF promoter and enhances cell viability in combination with mutant, but not wild-type, β-catenin. Together, our study reveals the alteration of WNT, hedgehog, histone methyltransferase and now N-CoR pathways across medulloblastomas and within specific subtypes of this disease, and nominates the RNA helicase DDX3X as a component of pathogenic β-catenin signalling in medulloblastoma.

Published
2012

2. Data from Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer

Author

Hammerman, Peter S., primary, Sos, Martin L., primary, Ramos, Alex H., primary, Xu, Chunxiao, primary, Dutt, Amit, primary, Zhou, Wenjun, primary, Brace, Lear E., primary, Woods, Brittany A., primary, Lin, Wenchu, primary, Zhang, Jianming, primary, Deng, Xianming, primary, Lim, Sang Min, primary, Heynck, Stefanie, primary, Peifer, Martin, primary, Simard, Jeffrey R., primary, Lawrence, Michael S., primary, Onofrio, Robert C., primary, Salvesen, Helga B., primary, Seidel, Danila, primary, Zander, Thomas, primary, Heuckmann, Johannes M., primary, Soltermann, Alex, primary, Moch, Holger, primary, Koker, Mirjam, primary, Leenders, Frauke, primary, Gabler, Franziska, primary, Querings, Silvia, primary, Ansén, Sascha, primary, Brambilla, Elisabeth, primary, Brambilla, Christian, primary, Lorimier, Philippe, primary, Brustugun, Odd Terje, primary, Helland, Åslaug, primary, Petersen, Iver, primary, Clement, Joachim H., primary, Groen, Harry, primary, Timens, Wim, primary, Sietsma, Hannie, primary, Stoelben, Erich, primary, Wolf, Jürgen, primary, Beer, David G., primary, Tsao, Ming Sound, primary, Hanna, Megan, primary, Hatton, Charles, primary, Eck, Michael J., primary, Janne, Pasi A., primary, Johnson, Bruce E., primary, Winckler, Wendy, primary, Greulich, Heidi, primary, Bass, Adam J., primary, Cho, Jeonghee, primary, Rauh, Daniel, primary, Gray, Nathanael S., primary, Wong, Kwok-Kin, primary, Haura, Eric B., primary, Thomas, Roman K., primary, and Meyerson, Matthew, primary

Published
2023
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3. Interview with Dr. Meyerson from Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer

Author

Hammerman, Peter S., primary, Sos, Martin L., primary, Ramos, Alex H., primary, Xu, Chunxiao, primary, Dutt, Amit, primary, Zhou, Wenjun, primary, Brace, Lear E., primary, Woods, Brittany A., primary, Lin, Wenchu, primary, Zhang, Jianming, primary, Deng, Xianming, primary, Lim, Sang Min, primary, Heynck, Stefanie, primary, Peifer, Martin, primary, Simard, Jeffrey R., primary, Lawrence, Michael S., primary, Onofrio, Robert C., primary, Salvesen, Helga B., primary, Seidel, Danila, primary, Zander, Thomas, primary, Heuckmann, Johannes M., primary, Soltermann, Alex, primary, Moch, Holger, primary, Koker, Mirjam, primary, Leenders, Frauke, primary, Gabler, Franziska, primary, Querings, Silvia, primary, Ansén, Sascha, primary, Brambilla, Elisabeth, primary, Brambilla, Christian, primary, Lorimier, Philippe, primary, Brustugun, Odd Terje, primary, Helland, Åslaug, primary, Petersen, Iver, primary, Clement, Joachim H., primary, Groen, Harry, primary, Timens, Wim, primary, Sietsma, Hannie, primary, Stoelben, Erich, primary, Wolf, Jürgen, primary, Beer, David G., primary, Tsao, Ming Sound, primary, Hanna, Megan, primary, Hatton, Charles, primary, Eck, Michael J., primary, Janne, Pasi A., primary, Johnson, Bruce E., primary, Winckler, Wendy, primary, Greulich, Heidi, primary, Bass, Adam J., primary, Cho, Jeonghee, primary, Rauh, Daniel, primary, Gray, Nathanael S., primary, Wong, Kwok-Kin, primary, Haura, Eric B., primary, Thomas, Roman K., primary, and Meyerson, Matthew, primary

Published
2023
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4. Supplementary Figure Legends 1-7 from Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer

Author

Hammerman, Peter S., primary, Sos, Martin L., primary, Ramos, Alex H., primary, Xu, Chunxiao, primary, Dutt, Amit, primary, Zhou, Wenjun, primary, Brace, Lear E., primary, Woods, Brittany A., primary, Lin, Wenchu, primary, Zhang, Jianming, primary, Deng, Xianming, primary, Lim, Sang Min, primary, Heynck, Stefanie, primary, Peifer, Martin, primary, Simard, Jeffrey R., primary, Lawrence, Michael S., primary, Onofrio, Robert C., primary, Salvesen, Helga B., primary, Seidel, Danila, primary, Zander, Thomas, primary, Heuckmann, Johannes M., primary, Soltermann, Alex, primary, Moch, Holger, primary, Koker, Mirjam, primary, Leenders, Frauke, primary, Gabler, Franziska, primary, Querings, Silvia, primary, Ansén, Sascha, primary, Brambilla, Elisabeth, primary, Brambilla, Christian, primary, Lorimier, Philippe, primary, Brustugun, Odd Terje, primary, Helland, Åslaug, primary, Petersen, Iver, primary, Clement, Joachim H., primary, Groen, Harry, primary, Timens, Wim, primary, Sietsma, Hannie, primary, Stoelben, Erich, primary, Wolf, Jürgen, primary, Beer, David G., primary, Tsao, Ming Sound, primary, Hanna, Megan, primary, Hatton, Charles, primary, Eck, Michael J., primary, Janne, Pasi A., primary, Johnson, Bruce E., primary, Winckler, Wendy, primary, Greulich, Heidi, primary, Bass, Adam J., primary, Cho, Jeonghee, primary, Rauh, Daniel, primary, Gray, Nathanael S., primary, Wong, Kwok-Kin, primary, Haura, Eric B., primary, Thomas, Roman K., primary, and Meyerson, Matthew, primary

Published
2023
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5. Supplementary Figures 1-7 from Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer

Author

Hammerman, Peter S., primary, Sos, Martin L., primary, Ramos, Alex H., primary, Xu, Chunxiao, primary, Dutt, Amit, primary, Zhou, Wenjun, primary, Brace, Lear E., primary, Woods, Brittany A., primary, Lin, Wenchu, primary, Zhang, Jianming, primary, Deng, Xianming, primary, Lim, Sang Min, primary, Heynck, Stefanie, primary, Peifer, Martin, primary, Simard, Jeffrey R., primary, Lawrence, Michael S., primary, Onofrio, Robert C., primary, Salvesen, Helga B., primary, Seidel, Danila, primary, Zander, Thomas, primary, Heuckmann, Johannes M., primary, Soltermann, Alex, primary, Moch, Holger, primary, Koker, Mirjam, primary, Leenders, Frauke, primary, Gabler, Franziska, primary, Querings, Silvia, primary, Ansén, Sascha, primary, Brambilla, Elisabeth, primary, Brambilla, Christian, primary, Lorimier, Philippe, primary, Brustugun, Odd Terje, primary, Helland, Åslaug, primary, Petersen, Iver, primary, Clement, Joachim H., primary, Groen, Harry, primary, Timens, Wim, primary, Sietsma, Hannie, primary, Stoelben, Erich, primary, Wolf, Jürgen, primary, Beer, David G., primary, Tsao, Ming Sound, primary, Hanna, Megan, primary, Hatton, Charles, primary, Eck, Michael J., primary, Janne, Pasi A., primary, Johnson, Bruce E., primary, Winckler, Wendy, primary, Greulich, Heidi, primary, Bass, Adam J., primary, Cho, Jeonghee, primary, Rauh, Daniel, primary, Gray, Nathanael S., primary, Wong, Kwok-Kin, primary, Haura, Eric B., primary, Thomas, Roman K., primary, and Meyerson, Matthew, primary

Published
2023
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6. Supplementary Table 1 from Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer

Author

Hammerman, Peter S., primary, Sos, Martin L., primary, Ramos, Alex H., primary, Xu, Chunxiao, primary, Dutt, Amit, primary, Zhou, Wenjun, primary, Brace, Lear E., primary, Woods, Brittany A., primary, Lin, Wenchu, primary, Zhang, Jianming, primary, Deng, Xianming, primary, Lim, Sang Min, primary, Heynck, Stefanie, primary, Peifer, Martin, primary, Simard, Jeffrey R., primary, Lawrence, Michael S., primary, Onofrio, Robert C., primary, Salvesen, Helga B., primary, Seidel, Danila, primary, Zander, Thomas, primary, Heuckmann, Johannes M., primary, Soltermann, Alex, primary, Moch, Holger, primary, Koker, Mirjam, primary, Leenders, Frauke, primary, Gabler, Franziska, primary, Querings, Silvia, primary, Ansén, Sascha, primary, Brambilla, Elisabeth, primary, Brambilla, Christian, primary, Lorimier, Philippe, primary, Brustugun, Odd Terje, primary, Helland, Åslaug, primary, Petersen, Iver, primary, Clement, Joachim H., primary, Groen, Harry, primary, Timens, Wim, primary, Sietsma, Hannie, primary, Stoelben, Erich, primary, Wolf, Jürgen, primary, Beer, David G., primary, Tsao, Ming Sound, primary, Hanna, Megan, primary, Hatton, Charles, primary, Eck, Michael J., primary, Janne, Pasi A., primary, Johnson, Bruce E., primary, Winckler, Wendy, primary, Greulich, Heidi, primary, Bass, Adam J., primary, Cho, Jeonghee, primary, Rauh, Daniel, primary, Gray, Nathanael S., primary, Wong, Kwok-Kin, primary, Haura, Eric B., primary, Thomas, Roman K., primary, and Meyerson, Matthew, primary

Published
2023
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7. Supplementary Information from Focal Gains of VEGFA and Molecular Classification of Hepatocellular Carcinoma

Author

Chiang, Derek Y., primary, Villanueva, Augusto, primary, Hoshida, Yujin, primary, Peix, Judit, primary, Newell, Philippa, primary, Minguez, Beatriz, primary, LeBlanc, Amanda C., primary, Donovan, Diana J., primary, Thung, Swan N., primary, Solé, Manel, primary, Tovar, Victoria, primary, Alsinet, Clara, primary, Ramos, Alex H., primary, Barretina, Jordi, primary, Roayaie, Sasan, primary, Schwartz, Myron, primary, Waxman, Samuel, primary, Bruix, Jordi, primary, Mazzaferro, Vincenzo, primary, Ligon, Azra H., primary, Najfeld, Vesna, primary, Friedman, Scott L., primary, Sellers, William R., primary, Meyerson, Matthew, primary, and Llovet, Josep M., primary

Published
2023
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8. Supplementary Methods from Gastrointestinal Adenocarcinomas of the Esophagus, Stomach, and Colon Exhibit Distinct Patterns of Genome Instability and Oncogenesis

Author

Dulak, Austin M., primary, Schumacher, Steven E., primary, van Lieshout, Jasper, primary, Imamura, Yu, primary, Fox, Cameron, primary, Shim, Byoungyong, primary, Ramos, Alex H., primary, Saksena, Gordon, primary, Baca, Sylvan C., primary, Baselga, Jose, primary, Tabernero, Josep, primary, Barretina, Jordi, primary, Enzinger, Peter C., primary, Corso, Giovanni, primary, Roviello, Franco, primary, Lin, Lin, primary, Bandla, Santhoshi, primary, Luketich, James D., primary, Pennathur, Arjun, primary, Meyerson, Matthew, primary, Ogino, Shuji, primary, Shivdasani, Ramesh A., primary, Beer, David G., primary, Godfrey, Tony E., primary, Beroukhim, Rameen, primary, and Bass, Adam J., primary

Published
2023
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9. Data from Gastrointestinal Adenocarcinomas of the Esophagus, Stomach, and Colon Exhibit Distinct Patterns of Genome Instability and Oncogenesis

Author

Dulak, Austin M., primary, Schumacher, Steven E., primary, van Lieshout, Jasper, primary, Imamura, Yu, primary, Fox, Cameron, primary, Shim, Byoungyong, primary, Ramos, Alex H., primary, Saksena, Gordon, primary, Baca, Sylvan C., primary, Baselga, Jose, primary, Tabernero, Josep, primary, Barretina, Jordi, primary, Enzinger, Peter C., primary, Corso, Giovanni, primary, Roviello, Franco, primary, Lin, Lin, primary, Bandla, Santhoshi, primary, Luketich, James D., primary, Pennathur, Arjun, primary, Meyerson, Matthew, primary, Ogino, Shuji, primary, Shivdasani, Ramesh A., primary, Beer, David G., primary, Godfrey, Tony E., primary, Beroukhim, Rameen, primary, and Bass, Adam J., primary

Published
2023
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10. Supplementary Figure 14 from Gastrointestinal Adenocarcinomas of the Esophagus, Stomach, and Colon Exhibit Distinct Patterns of Genome Instability and Oncogenesis

Author

Dulak, Austin M., primary, Schumacher, Steven E., primary, van Lieshout, Jasper, primary, Imamura, Yu, primary, Fox, Cameron, primary, Shim, Byoungyong, primary, Ramos, Alex H., primary, Saksena, Gordon, primary, Baca, Sylvan C., primary, Baselga, Jose, primary, Tabernero, Josep, primary, Barretina, Jordi, primary, Enzinger, Peter C., primary, Corso, Giovanni, primary, Roviello, Franco, primary, Lin, Lin, primary, Bandla, Santhoshi, primary, Luketich, James D., primary, Pennathur, Arjun, primary, Meyerson, Matthew, primary, Ogino, Shuji, primary, Shivdasani, Ramesh A., primary, Beer, David G., primary, Godfrey, Tony E., primary, Beroukhim, Rameen, primary, and Bass, Adam J., primary

Published
2023
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11. Data from Focal Gains of VEGFA and Molecular Classification of Hepatocellular Carcinoma

Author

Chiang, Derek Y., primary, Villanueva, Augusto, primary, Hoshida, Yujin, primary, Peix, Judit, primary, Newell, Philippa, primary, Minguez, Beatriz, primary, LeBlanc, Amanda C., primary, Donovan, Diana J., primary, Thung, Swan N., primary, Solé, Manel, primary, Tovar, Victoria, primary, Alsinet, Clara, primary, Ramos, Alex H., primary, Barretina, Jordi, primary, Roayaie, Sasan, primary, Schwartz, Myron, primary, Waxman, Samuel, primary, Bruix, Jordi, primary, Mazzaferro, Vincenzo, primary, Ligon, Azra H., primary, Najfeld, Vesna, primary, Friedman, Scott L., primary, Sellers, William R., primary, Meyerson, Matthew, primary, and Llovet, Josep M., primary

Published
2023
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12. Supplementary Note 1 from Gastrointestinal Adenocarcinomas of the Esophagus, Stomach, and Colon Exhibit Distinct Patterns of Genome Instability and Oncogenesis

Author

Dulak, Austin M., primary, Schumacher, Steven E., primary, van Lieshout, Jasper, primary, Imamura, Yu, primary, Fox, Cameron, primary, Shim, Byoungyong, primary, Ramos, Alex H., primary, Saksena, Gordon, primary, Baca, Sylvan C., primary, Baselga, Jose, primary, Tabernero, Josep, primary, Barretina, Jordi, primary, Enzinger, Peter C., primary, Corso, Giovanni, primary, Roviello, Franco, primary, Lin, Lin, primary, Bandla, Santhoshi, primary, Luketich, James D., primary, Pennathur, Arjun, primary, Meyerson, Matthew, primary, Ogino, Shuji, primary, Shivdasani, Ramesh A., primary, Beer, David G., primary, Godfrey, Tony E., primary, Beroukhim, Rameen, primary, and Bass, Adam J., primary

Published
2023
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13. Supplementary Legends for Figures 1-14, and Tables 1-6 from Gastrointestinal Adenocarcinomas of the Esophagus, Stomach, and Colon Exhibit Distinct Patterns of Genome Instability and Oncogenesis

Author

Dulak, Austin M., primary, Schumacher, Steven E., primary, van Lieshout, Jasper, primary, Imamura, Yu, primary, Fox, Cameron, primary, Shim, Byoungyong, primary, Ramos, Alex H., primary, Saksena, Gordon, primary, Baca, Sylvan C., primary, Baselga, Jose, primary, Tabernero, Josep, primary, Barretina, Jordi, primary, Enzinger, Peter C., primary, Corso, Giovanni, primary, Roviello, Franco, primary, Lin, Lin, primary, Bandla, Santhoshi, primary, Luketich, James D., primary, Pennathur, Arjun, primary, Meyerson, Matthew, primary, Ogino, Shuji, primary, Shivdasani, Ramesh A., primary, Beer, David G., primary, Godfrey, Tony E., primary, Beroukhim, Rameen, primary, and Bass, Adam J., primary

Published
2023
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14. Supplementary Note 3 from Gastrointestinal Adenocarcinomas of the Esophagus, Stomach, and Colon Exhibit Distinct Patterns of Genome Instability and Oncogenesis

Author

Dulak, Austin M., primary, Schumacher, Steven E., primary, van Lieshout, Jasper, primary, Imamura, Yu, primary, Fox, Cameron, primary, Shim, Byoungyong, primary, Ramos, Alex H., primary, Saksena, Gordon, primary, Baca, Sylvan C., primary, Baselga, Jose, primary, Tabernero, Josep, primary, Barretina, Jordi, primary, Enzinger, Peter C., primary, Corso, Giovanni, primary, Roviello, Franco, primary, Lin, Lin, primary, Bandla, Santhoshi, primary, Luketich, James D., primary, Pennathur, Arjun, primary, Meyerson, Matthew, primary, Ogino, Shuji, primary, Shivdasani, Ramesh A., primary, Beer, David G., primary, Godfrey, Tony E., primary, Beroukhim, Rameen, primary, and Bass, Adam J., primary

Published
2023
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15. Supplementary Figures 1-13 from Gastrointestinal Adenocarcinomas of the Esophagus, Stomach, and Colon Exhibit Distinct Patterns of Genome Instability and Oncogenesis

Author

Dulak, Austin M., primary, Schumacher, Steven E., primary, van Lieshout, Jasper, primary, Imamura, Yu, primary, Fox, Cameron, primary, Shim, Byoungyong, primary, Ramos, Alex H., primary, Saksena, Gordon, primary, Baca, Sylvan C., primary, Baselga, Jose, primary, Tabernero, Josep, primary, Barretina, Jordi, primary, Enzinger, Peter C., primary, Corso, Giovanni, primary, Roviello, Franco, primary, Lin, Lin, primary, Bandla, Santhoshi, primary, Luketich, James D., primary, Pennathur, Arjun, primary, Meyerson, Matthew, primary, Ogino, Shuji, primary, Shivdasani, Ramesh A., primary, Beer, David G., primary, Godfrey, Tony E., primary, Beroukhim, Rameen, primary, and Bass, Adam J., primary

Published
2023
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16. Supplementary Tables 1-6 from Gastrointestinal Adenocarcinomas of the Esophagus, Stomach, and Colon Exhibit Distinct Patterns of Genome Instability and Oncogenesis

Author

Dulak, Austin M., primary, Schumacher, Steven E., primary, van Lieshout, Jasper, primary, Imamura, Yu, primary, Fox, Cameron, primary, Shim, Byoungyong, primary, Ramos, Alex H., primary, Saksena, Gordon, primary, Baca, Sylvan C., primary, Baselga, Jose, primary, Tabernero, Josep, primary, Barretina, Jordi, primary, Enzinger, Peter C., primary, Corso, Giovanni, primary, Roviello, Franco, primary, Lin, Lin, primary, Bandla, Santhoshi, primary, Luketich, James D., primary, Pennathur, Arjun, primary, Meyerson, Matthew, primary, Ogino, Shuji, primary, Shivdasani, Ramesh A., primary, Beer, David G., primary, Godfrey, Tony E., primary, Beroukhim, Rameen, primary, and Bass, Adam J., primary

Published
2023
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17. Supplementary Note 2 from Gastrointestinal Adenocarcinomas of the Esophagus, Stomach, and Colon Exhibit Distinct Patterns of Genome Instability and Oncogenesis

Author

Dulak, Austin M., primary, Schumacher, Steven E., primary, van Lieshout, Jasper, primary, Imamura, Yu, primary, Fox, Cameron, primary, Shim, Byoungyong, primary, Ramos, Alex H., primary, Saksena, Gordon, primary, Baca, Sylvan C., primary, Baselga, Jose, primary, Tabernero, Josep, primary, Barretina, Jordi, primary, Enzinger, Peter C., primary, Corso, Giovanni, primary, Roviello, Franco, primary, Lin, Lin, primary, Bandla, Santhoshi, primary, Luketich, James D., primary, Pennathur, Arjun, primary, Meyerson, Matthew, primary, Ogino, Shuji, primary, Shivdasani, Ramesh A., primary, Beer, David G., primary, Godfrey, Tony E., primary, Beroukhim, Rameen, primary, and Bass, Adam J., primary

Published
2023
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18. The Mutational Landscape of Head and Neck Squamous Cell Carcinoma

Author

Stransky, Nicolas, Egloff, Ann Marie, Tward, Aaron D., Kostic, Aleksandar D., Cibulskis, Kristian, Sivachenko, Andrey, Kryukov, Gregory V., Lawrence, Michael S., Sougnez, Carrie, McKenna, Aaron, Shefler, Erica, Ramos, Alex H., Stojanov, Petar, Carter, Scott L., Voet, Douglas, Cortés, Maria L., Auclair, Daniel, Berger, Michael F., Saksena, Gordon, Guiducci, Candace, Onofrio, Robert C., Parkin, Melissa, Romkes, Marjorie, Weissfeld, Joel L., Seethala, Raja R., Wang, Lin, Rangel-Escareño, Claudia, Fernandez-Lopez, Juan Carlos, Hidalgo-Miranda, Alfredo, Melendez-Zajgla, Jorge, Winckler, Wendy, Ardlie, Kristin, Gabriel, Stacey B., Meyerson, Matthew, Lander, Eric S., Getz, Gad, Golub, Todd R., Garraway, Levi A., and Grandis, Jennifer R.

Published
2011
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19. Drug-Sensitive FGFR2 Mutations in Endometrial Carcinoma

Author

Dutt, Amit, Salvesen, Helga B., Chen, Tzu-Hsiu, Ramos, Alex H., Onofrio, Robert C., Hatton, Charlie, Nicoletti, Richard, Winckler, Wendy, Grewal, Rupinder, Hanna, Megan, Wyhs, Nicolas, Ziaugra, Liuda, Richter, Daniel J., Trovik, Jone, Engelsen, Ingeborg B., Stefansson, Ingunn M., Fennell, Tim, Cibulskis, Kristian, Zody, Michael C., Akslen, Lars A., Gabriel, Stacey, Wong, Kwok-Kin, Sellers, William R., Meyerson, Matthew, and Greulich, Heidi

Published
2008
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21. Sequence analysis of mutations and translocations across breast cancer subtypes

Author

Banerji, Shantanu, Cibulskis, Kristian, Rangel-Escareno, Claudia, Brown, Kristin K., Carter, Scott L., Frederick, Abbie M., Lawrence, Michael S., Sivachenko, Andrey Y., Sougnez, Carrie, Zou, Lihua, Cortes, Maria L., Fernandez-Lopez, Juan C., Peng, Shouyong, Ardlie, Kristin G., Auclair, Daniel, Bautista-Pina, Veronica, Duke, Fujiko, Francis, Joshua, Jung, Joonil, Maffuz-Aziz, Antonio, Onofrio, Robert C., Parkin, Melissa, Pho, Nam H., Quintanar-Jurado, Valeria, Ramos, Alex H., Rebollar-Vega, Rosa, Rodriguez-Cuevas, Sergio, Romero-Cordoba, Sandra L., Schumacher, Steven E., Stransky, Nicolas, Thompson, Kristin M., Uribe-Figueroa, Laura, Baselga, Jose, Beroukhim, Rameen, Polyak, Kornelia, Sgroi, Dennis C., Richardson, Andrea L., Jimenez-Sanchez, Gerardo, Lander, Eric S., Gabriel, Stacey B., Garraway, Levi A., Golub, Todd R., Melendez-Zajgla, Jorge, Toker, Alex, Getz, Gad, Hidalgo-Miranda, Alfredo, and Meyerson, Matthew

Subjects
Gene mutations -- Research, Exome sequencing -- Research, Translocation (Genetics) -- Research, Cancer -- Genetic aspects, Breast cancer -- Genetic aspects -- Analysis -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Shantanu Banerji [1, 2, 3, 15, 16]; Kristian Cibulskis [1, 16]; Claudia Rangel-Escareno [4, 16]; Kristin K. Brown [5, 16]; Scott L. Carter [1]; Abbie M. Frederick [1]; Michael [...]

Published
2012
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22. Mutational heterogeneity in cancer and the search for new cancer-associated genes

Author

Lawrence, Michael S., Stojanov, Petar, Polak, Paz, Kryukov, Gregory V., Cibulskis, Kristian, Sivachenko, Andrey, Carter, Scott L., Stewart, Chip, Mermel, Craig H., Roberts, Steven A., Kiezun, Adam, Hammerman, Peter S., McKenna, Aaron, Drier, Yotam, Zou, Lihua, Ramos, Alex H., Pugh, Trevor J., Stransky, Nicolas, Helman, Elena, Kim, Jaegil, Sougnez, Carrie, Ambrogio, Lauren, Nickerson, Elizabeth, Shefler, Erica, Cortés, Maria L., Auclair, Daniel, Saksena, Gordon, Voet, Douglas, Noble, Michael, DiCara, Daniel, Lin, Pei, Lichtenstein, Lee, Heiman, David I., Fennell, Timothy, Imielinski, Marcin, Hernandez, Bryan, Hodis, Eran, Baca, Sylvan, Dulak, Austin M., Lohr, Jens, Landau, Dan-Avi, Wu, Catherine J., Melendez-Zajgla, Jorge, Hidalgo-Miranda, Alfredo, Koren, Amnon, McCarroll, Steven A., Mora, Jaume, Lee, Ryan S., Crompton, Brian, Onofrio, Robert, Parkin, Melissa, Winckler, Wendy, Ardlie, Kristin, Gabriel, Stacey B., Roberts, Charles W. M., Biegel, Jaclyn A., Stegmaier, Kimberly, Bass, Adam J., Garraway, Levi A., Meyerson, Matthew, Golub, Todd R., Gordenin, Dmitry A., Sunyaev, Shamil, Lander, Eric S., and Getz, Gad

Published
2013
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23. Comprehensive molecular characterization of human colon and rectal cancer

Author

Muzny, Donna M., Bainbridge, Matthew N., Chang, Kyle, Dinh, Huyen H., Drummond, Jennifer A., Fowler, Gerald, Kovar, Christie L., Lewis, Lora R., Morgan, Margaret B., Newsham, Irene F., Reid, Jeffrey G., Santibanez, Jireh, Shinbrot, Eve, Trevino, Lisa R., Wu, Yuan-Qing, Wang, Min, Gunaratne, Preethi, Donehower, Lawrence A., Creighton, Chad J., Wheeler, David A., Gibbs, Richard A., Lawrence, Michael S., Voet, Douglas, Jing, Rui, Cibulskis, Kristian, Sivachenko, Andrey, Stojanov, Petar, McKenna, Aaron, Lander, Eric S., Gabriel, Stacey, Getz, Gad, Ding, Li, Fulton, Robert S., Koboldt, Daniel C., Wylie, Todd, Walker, Jason, Dooling, David J., Fulton, Lucinda, Delehaunty, Kim D., Fronick, Catrina C., Demeter, Ryan, Mardis, Elaine R., Wilson, Richard K., Chu, Andy, Chun, Hye-Jung E., Mungall, Andrew J., Pleasance, Erin, Robertson, Gordon A., Stoll, Dominik, Balasundaram, Miruna, Birol, Inanc, Butterfield, Yaron S. N., Chuah, Eric, Coope, Robin J. N., Dhalla, Noreen, Guin, Ranabir, Hirst, Carrie, Hirst, Martin, Holt, Robert A., Lee, Darlene, Li, Haiyan I., Mayo, Michael, Moore, Richard A., Schein, Jacqueline E., Slobodan, Jared R., Tam, Angela, Thiessen, Nina, Varhol, Richard, Zeng, Thomas, Zhao, Yongjun, Jones, Steven J. M., Marra, Marco A., Bass, Adam J., Ramos, Alex H., Saksena, Gordon, Cherniack, Andrew D., Schumacher, Stephen E., Tabak, Barbara, Carter, Scott L., Pho, Nam H., Nguyen, Huy, Onofrio, Robert C., Crenshaw, Andrew, Ardlie, Kristin, Beroukhim, Rameen, Winckler, Wendy, Meyerson, Matthew, Protopopov, Alexei, Zhang, Juinhua, Hadjipanayis, Angela, Lee, Eunjung, Xi, Ruibin, Yang, Lixing, Ren, Xiaojia, Zhang, Hailei, Sathiamoorthy, Narayanan, Shukla, Sachet, Chen, Peng-Chieh, Haseley, Psalm, Xiao, Yonghong, Lee, Semin, Seidman, Jonathan, Chin, Lynda, Park, Peter J., Kucherlapati, Raju, Auman, Todd J., Hoadley, Katherine A., Du, Ying, Wilkerson, Matthew D., Shi, Yan, Liquori, Christina, Meng, Shaowu, Li, Ling, Turman, Yidi J., Topal, Michael D., Tan, Donghui, Waring, Scot, Buda, Elizabeth, Walsh, Jesse, Jones, Corbin D., Mieczkowski, Piotr A., Singh, Darshan, Wu, Junyuan, Gulabani, Anisha, Dolina, Peter, Bodenheimer, Tom, Hoyle, Alan P., Simons, Janae V., Soloway, Matthew, Mose, Lisle E., Jefferys, Stuart R., Balu, Saianand, O’Connor, Brian D., Prins, Jan F., Chiang, Derek Y., Hayes, Neil D., Perou, Charles M., Hinoue, Toshinori, Weisenberger, Daniel J., Maglinte, Dennis T., Pan, Fei, Berman, Benjamin P., Van Den Berg, David J., Shen, Hui, Triche, Timothy, Jr, Baylin, Stephen B., Laird, Peter W., Noble, Michael, Voet, Doug, Gehlenborg, Nils, DiCara, Daniel, Wu, Chang-Jiun, Yingchun Liu, Spring, Zhou, Lihua, Lin, Pei, Park, Richard W., Nazaire, Marc-Danie, Robinson, Jim, Thorvaldsdottir, Helga, Mesirov, Jill, Thorsson, Vesteinn, Reynolds, Sheila M., Bernard, Brady, Kreisberg, Richard, Lin, Jake, Iype, Lisa, Bressler, Ryan, Erkkilä, Timo, Gundapuneni, Madhumati, Liu, Yuexin, Norberg, Adam, Robinson, Tom, Yang, Da, Zhang, Wei, Shmulevich, Ilya, de Ronde, Jorma J., Schultz, Nikolaus, Cerami, Ethan, Ciriello, Giovanni, Goldberg, Arthur P., Gross, Benjamin, Jacobsen, Anders, Gao, Jianjiong, Kaczkowski, Bogumil, Sinha, Rileen, Aksoy, Arman B., Antipin, Yevgeniy, Reva, Boris, Shen, Ronglai, Taylor, Barry S., Chan, Timothy A., Ladanyi, Marc, Sander, Chris, Akbani, Rehan, Zhang, Nianxiang, Broom, Bradley M., Casasent, Tod, Unruh, Anna, Wakefield, Chris, Hamilton, Stanley R., Cason, Craig R., Baggerly, Keith A., Weinstein, John N., Haussler, David, Benz, Christopher C., Stuart, Joshua M., Benz, Stephen C., Sanborn, Zachary J., Vaske, Charles J., Zhu, Jingchun, Szeto, Christopher, Scott, Gary K., Yau, Christina, Ng, Sam, Goldstein, Ted, Ellrott, Kyle, Collisson, Eric, Cozen, Aaron E., Zerbino, Daniel, Wilks, Christopher, Craft, Brian, Spellman, Paul, Penny, Robert, Shelton, Troy, Hatfield, Martha, Morris, Scott, Yena, Peggy, Shelton, Candace, Sherman, Mark, Paulauskis, Joseph, Gastier-Foster, Julie M., Bowen, Jay, Ramirez, Nilsa C., Black, Aaron, Pyatt, Robert, Wise, Lisa, White, Peter, Bertagnolli, Monica, Brown, Jen, Chu, Gerald C., Czerwinski, Christine, Denstman, Fred, Dhir, Rajiv, Dörner, Arnulf, Fuchs, Charles S., Guillem, Jose G., Iacocca, Mary, Juhl, Hartmut, Kaufman, Andrew, Kohl, Bernard, III, Van Le, Xuan, Mariano, Maria C., Medina, Elizabeth N., Meyers, Michael, Nash, Garrett M., Paty, Phillip B., Petrelli, Nicholas, Rabeno, Brenda, Richards, William G., Solit, David, Swanson, Pat, Temple, Larissa, Tepper, Joel E., Thorp, Richard, Vakiani, Efsevia, Weiser, Martin R., Willis, Joseph E., Witkin, Gary, Zeng, Zhaoshi, Zinner, Michael J., Zornig, Carsten, Jensen, Mark A., Sfeir, Robert, Kahn, Ari B., Chu, Anna L., Kothiyal, Prachi, Wang, Zhining, Snyder, Eric E., Pontius, Joan, Pihl, Todd D., Ayala, Brenda, Backus, Mark, Walton, Jessica, Whitmore, Jon, Baboud, Julien, Berton, Dominique L., Nicholls, Matthew C., Srinivasan, Deepak, Raman, Rohini, Girshik, Stanley, Kigonya, Peter A., Alonso, Shelley, Sanbhadti, Rashmi N., Barletta, Sean P., Greene, John M., Pot, David A., Mills Shaw, Kenna R., Dillon, Laura A. L., Buetow, Ken, Davidsen, Tanja, Demchok, John A., Eley, Greg, Ferguson, Martin, Fielding, Peter, Schaefer, Carl, Sheth, Margi, Yang, Liming, Guyer, Mark S., Ozenberger, Bradley A., Palchik, Jacqueline D., Peterson, Jane, Sofia, Heidi J., and Thomson, Elizabeth

Published
2012
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24. Melanoma genome sequencing reveals frequent PREX2 mutations

Author

Berger, Michael F., Hodis, Eran, Heffernan, Timothy P., Deribe, Yonathan Lissanu, Lawrence, Michael S., Protopopov, Alexei, Ivanova, Elena, Watson, Ian R., Nickerson, Elizabeth, Ghosh, Papia, Zhang, Hailei, Zeid, Rhamy, Ren, Xiaojia, Cibulskis, Kristian, Sivachenko, Andrey Y., Wagle, Nikhil, Sucker, Antje, Sougnez, Carrie, Onofrio, Robert, Ambrogio, Lauren, Auclair, Daniel, Fennell, Timothy, Carter, Scott L., Drier, Yotam, Stojanov, Petar, Singer, Meredith A., Voet, Douglas, Jing, Rui, Saksena, Gordon, Barretina, Jordi, Ramos, Alex H., Pugh, Trevor J., Stransky, Nicolas, Parkin, Melissa, Winckler, Wendy, Mahan, Scott, Ardlie, Kristin, Baldwin, Jennifer, Wargo, Jennifer, Schadendorf, Dirk, Meyerson, Matthew, Gabriel, Stacey B., Golub, Todd R., Wagner, Stephan N., Lander, Eric S., Getz, Gad, Chin, Lynda, and Garraway, Levi A.

Published
2012
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25. Initial genome sequencing and analysis of multiple myeloma

Author

Chapman, Michael A., Lawrence, Michael S., Keats, Jonathan J., Cibulskis, Kristian, Sougnez, Carrie, Schinzel, Anna C., Harview, Christina L., Brunet, Jean-Philippe, Ahmann, Gregory J., Adli, Mazhar, Anderson, Kenneth C., Ardlie, Kristin G., Auclair, Daniel, Baker, Angela, Bergsagel, Leif P., Bernstein, Bradley E., Drier, Yotam, Fonseca, Rafael, Gabriel, Stacey B., Hofmeister, Craig C., Jagannath, Sundar, Jakubowiak, Andrzej J., Krishnan, Amrita, Levy, Joan, Liefeld, Ted, Lonial, Sagar, Mahan, Scott, Mfuko, Bunmi, Monti, Stefano, Perkins, Louise M., Onofrio, Robb, Pugh, Trevor J., Rajkumar, Vincent S., Ramos, Alex H., Siegel, David S., Sivachenko, Andrey, Stewart, Keith A., Trudel, Suzanne, Vij, Ravi, Voet, Douglas, Winckler, Wendy, Zimmerman, Todd, Carpten, John, Trent, Jeff, Hahn, William C., Garraway, Levi A., Meyerson, Matthew, Lander, Eric S., Getz, Gad, and Golub, Todd R.

Published
2011
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26. The genomic complexity of primary human prostate cancer

Author

Berger, Michael F., Lawrence, Michael S., Demichelis, Francesca, Drier, Yotam, Cibulskis, Kristian, Sivachenko, Andrey Y., Sboner, Andrea, Esgueva, Raquel, Pflueger, Dorothee, Sougnez, Carrie, Onofrio, Robert, Carter, Scott L., Park, Kyung, Habegger, Lukas, Ambrogio, Lauren, Fennell, Timothy, Parkin, Melissa, Saksena, Gordon, Voet, Douglas, Ramos, Alex H., Pugh, Trevor J., Wilkinson, Jane, Fisher, Sheila, Winckler, Wendy, Mahan, Scott, Ardlie, Kristin, Baldwin, Jennifer, Simons, Jonathan W., Kitabayashi, Naoki, MacDonald, Theresa Y., Kantoff, Philip W., Chin, Lynda, Gabriel, Stacey B., Gerstein, Mark B., Golub, Todd R., Meyerson, Matthew, Tewari, Ashutosh, Lander, Eric S., Getz, Gad, Rubin, Mark A., and Garraway, Levi A.

Published
2011
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27. Characterizing the cancer genome in lung adenocarcinoma

Author

Weir, Barbara A., Woo, Michele S., Getz, Gad, Perner, Sven, Ding, Li, Beroukhim, Rameen, Lin, William M., Province, Michael A., Kraja, Aldi, Johnson, Laura A., Shah, Kinjal, Sato, Mitsuo, Thomas, Roman K., Barletta, Justine A., Borecki, Ingrid B., Broderick, Stephen, Chang, Andrew C., Chiang, Derek Y., Chirieac, Lucian R., Cho, Jeonghee, Fujii, Yoshitaka, Gazdar, Adi F., Giordano, Thomas, Greulich, Heidi, Hanna, Megan, Johnson, Bruce E., Kris, Mark G., Lash, Alex, Lin, Ling, Lindeman, Neal, Mardis, Elaine R., McPherson, John D., Minna, John D., Morgan, Margaret B., Nadel, Mark, Orringer, Mark B., Osborne, John R., Ozenberger, Brad, Ramos, Alex H., Robinson, James, Roth, Jack A., Rusch, Valerie, Sasaki, Hidefumi, Shepherd, Frances, Sougnez, Carrie, Spitz, Margaret R., Tsao, Ming-Sound, Twomey, David, Verhaak, Roel G. W., Weinstock, George M., Wheeler, David A., Winckler, Wendy, Yoshizawa, Akihiko, Yu, Soyoung, Zakowski, Maureen F., Zhang, Qunyuan, Beer, David G., Wistuba, Ignacio I., Watson, Mark A., Garraway, Levi A., Ladanyi, Marc, Travis, William D., Pao, William, Rubin, Mark A., Gabriel, Stacey B., Gibbs, Richard A., Varmus, Harold E., Wilson, Richard K., Lander, Eric S., and Meyerson, Matthew

Published
2007
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29. A glimpse into the somatic mutation landscape of melanoma through exome sequencing of 121 tumor-normal pairs

Author

Hodis, Eran, Watson, Ian, Theurillat, Jean-Philippe, Zou, Lihua, Place, Chelsea, Nickerson, Elizabeth, Auclair, Daniel, Cibulskis, Kristian, Sivachenko, Andrey, Kryukov, Gregory, Stransky, Nicolas, Ramos, Alex H., Voet, Douglas, Lawrence, Michael S., Stojanov, Petar, Saksena, Gordon, McKenna, Aaron, Carter, Scott L., Pugh, Trevor, Noble, Michael, Lin, Pei, Lichtenstein, Lee, Zupko, Robert, Sougnez, Carrie, Guiducci, Candace, Onofrio, Robert C., Ambrogio, Lauren, Fennell, Timothy, Chong, Kelly, Winckler, Wendy, Ardlie, Kristin, Lander, Eric S., Golub, Todd, Meyerson, Matthew, Gabriel, Stacey B., Getz, Gad, Wagner, Stefan, Schadendorf, Dirk, Hoon, Dave S. B., Chin, Lynda, and Garraway, Levi A.

Subjects
Medizin
Published
2012

30. Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion

Author

Lawrence, Michael S, Bass, Adam J, Ramos, Alex H, Hoshida, Yujin, Sivachenko, Andrey, Pugh, Trevor, Drier, Yotam, Saksena, Gordon, Kaelin, William G, Chiang, Derek Y, Solit, David B, Sougnez, Carrie, Brace, Lear E, Stransky, Nicolas, Voet, Douglas, DePinho, Ronald A, Shao, Wenlin, Warmuth, Markus, Boutin, Adam T, Cibulskis, Kristian, Hahn, William C, Signoretti, Sabina, Spardy, Nicole, Parkin, Melissa, Chin, Lynda, Mishina, Yuji, Jing, Rui, Barretina, Jordi, Ogino, Shuji, Vakiani, Evi, Jimenez, Jose, and Verhaak, Roel G

Abstract

Prior studies have identified recurrent oncogenic mutations in colorectal adenocarcinoma1 and have surveyed exons of protein-coding genes for mutations in 11 affected individuals2,3. Here we report whole-genome sequencing from nine individuals with colorectal cancer, including primary colorectal tumors and matched adjacent non-tumor tissues, at an average of 30.7× and 31.9× coverage, respectively. We identify an average of 75 somatic rearrangements per tumor, including complex networks of translocations between pairs of chromosomes. Eleven rearrangements encode predicted in-frame fusion proteins, including a fusion of VTI1A and TCF7L2 found in 3 out of 97 colorectal cancers. Although TCF7L2 encodes TCF4, which cooperates with β-catenin4 in colorectal carcinogenesis5,6, the fusion lacks the TCF4 β-catenin–binding domain. We found a colorectal carcinoma cell line harboring the fusion gene to be dependent on VTI1A-TCF7L2 for anchorage-independent growth using RNA interference-mediated knockdown. This study shows previously unidentified levels of genomic rearrangements in colorectal carcinoma that can lead to essential gene fusions and other oncogenic events.

Published
2011
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31. A Landscape of Driver Mutations in Melanoma

Author

Massachusetts Institute of Technology. Department of Biology, Whitehead Institute for Biomedical Research, Lander, Eric S., Hodis, Eran, Watson, Ian R., Kryukov, Gregory V., Arold, Stefan T., Imielinski, Marcin, Theurillat, Jean-Philippe, Nickerson, Elizabeth, Auclair, Daniel, Li, Liren, Place, Chelsea, DiCara, Daniel, Ramos, Alex H., Lawrence, Michael S., Cibulskis, Kristian, Sivachenko, Andrey, Voet, Douglas, Saksena, Gordon, Stransky, Nicholas, Onofrio, Robert, Lander, Eric Steven, Massachusetts Institute of Technology. Department of Biology, Whitehead Institute for Biomedical Research, Lander, Eric S., Hodis, Eran, Watson, Ian R., Kryukov, Gregory V., Arold, Stefan T., Imielinski, Marcin, Theurillat, Jean-Philippe, Nickerson, Elizabeth, Auclair, Daniel, Li, Liren, Place, Chelsea, DiCara, Daniel, Ramos, Alex H., Lawrence, Michael S., Cibulskis, Kristian, Sivachenko, Andrey, Voet, Douglas, Saksena, Gordon, Stransky, Nicholas, Onofrio, Robert, and Lander, Eric Steven

Abstract

Despite recent insights into melanoma genetics, systematic surveys for driver mutations are challenged by an abundance of passenger mutations caused by carcinogenic UV light exposure. We developed a permutation-based framework to address this challenge, employing mutation data from intronic sequences to control for passenger mutational load on a per gene basis. Analysis of large-scale melanoma exome data by this approach discovered six novel melanoma genes (PPP6C, RAC1, SNX31, TACC1, STK19, and ARID2), three of which—RAC1, PPP6C, and STK19—harbored recurrent and potentially targetable mutations. Integration with chromosomal copy number data contextualized the landscape of driver mutations, providing oncogenic insights in BRAF- and NRAS-driven melanoma as well as those without known NRAS/BRAF mutations. The landscape also clarified a mutational basis for RB and p53 pathway deregulation in this malignancy. Finally, the spectrum of driver mutations provided unequivocal genomic evidence for a direct mutagenic role of UV light in melanoma pathogenesis., National Human Genome Research Institute (U.S.) (Large Scale Sequencing Program Grant U54 HG003067), Melanoma Research Alliance, National Cancer Institute (U.S.) (Support Grant CA-16672)

Published
2014

32. Focal Gains of Vascular Endothelial Growth Factor A and Molecular Classification of Hepatocellular Carcinoma

Author

Chiang, Derek Y., Villanueva, Augusto, Hoshida, Yujin, Peix, Judit, Newell, Philippa, Minguez, Beatriz, LeBlanc, Amanda C., Donovan, Diana J., Thung, Swan N., Sole, Manel, Tovar, Victoria, Alsinet, Clara, Ramos, Alex H., Barretina, Jordi, Roayaie, Sasan, Schwartz, Myron, Waxman, Samuel, Bruix, Jordi, Mazzaferro, Vincenzo, Ligon, Azra H., Najfeld, Vesna, Friedman, Scott L., Sellers, William R., Meyerson, Matthew, and Llovet, Josep M.

Subjects
Chromosome Aberrations, Vascular Endothelial Growth Factor A, Carcinoma, Hepatocellular, Lung Neoplasms, Gene Expression Profiling, Liver Neoplasms, Gene Dosage, Nucleic Acid Hybridization, Adenocarcinoma, Hepatitis C, Chronic, Prognosis, Article, Immunoenzyme Techniques, Survival Rate, Hepatitis B, Chronic, Tissue Array Analysis, Karyotyping, Biomarkers, Tumor, Humans, Chromosomes, Human, Pair 6, Chromosomes, Human, Pair 7, In Situ Hybridization, Fluorescence, Neoplasm Staging, Oligonucleotide Array Sequence Analysis, Signal Transduction
Abstract

Hepatocellular carcinomas represent the third leading cause of cancer-related deaths worldwide. The vast majority of cases arise in the context of chronic liver injury due to hepatitis B virus or hepatitis C virus infection. To identify genetic mechanisms of hepatocarcinogenesis, we characterized copy number alterations and gene expression profiles from the same set of tumors associated with hepatitis C virus. Most tumors harbored 1q gain, 8q gain, or 8p loss, with occasional alterations in 13 additional chromosome arms. In addition to amplifications at 11q13 in 6 of 103 tumors, 4 tumors harbored focal gains at 6p21 incorporating vascular endothelial growth factor A (VEGFA). Fluorescence in situ hybridization on an independent validation set of 210 tumors found 6p21 high-level gains in 14 tumors, as well as 2 tumors with 6p21 amplifications. Strikingly, this locus overlapped with copy gains in 4 of 371 lung adenocarcinomas. Overexpression of VEGFA via 6p21 gain in hepatocellular carcinomas suggested a novel, non-cell-autonomous mechanism of oncogene activation. Hierarchical clustering of gene expression among 91 of these tumors identified five classes, including "CTNNB1", "proliferation", "IFN-related", a novel class defined by polysomy of chromosome 7, and an unannotated class. These class labels were further supported by molecular data; mutations in CTNNB1 were enriched in the "CTNNB1" class, whereas insulin-like growth factor I receptor and RPS6 phosphorylation were enriched in the "proliferation" class. The enrichment of signaling pathway alterations in gene expression classes provides insights on hepatocellular carcinoma pathogenesis. Furthermore, the prevalence of VEGFA high-level gains in multiple tumor types suggests indications for clinical trials of antiangiogenic therapies.

Published
2008

34. NAMPT Is the Cellular Target of STF-31-Like Small-Molecule Probes

Author

Adams, Drew J., primary, Ito, Daisuke, additional, Rees, Matthew G., additional, Seashore-Ludlow, Brinton, additional, Puyang, Xiaoling, additional, Ramos, Alex H., additional, Cheah, Jaime H., additional, Clemons, Paul A., additional, Warmuth, Markus, additional, Zhu, Ping, additional, Shamji, Alykhan F., additional, and Schreiber, Stuart L., additional

Published
2014
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35. Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer

Author

Whitaker College of Health Sciences and Technology, Broad Institute of MIT and Harvard, Harvard University--MIT Division of Health Sciences and Technology, Meyerson, Matthew L., Dutt, Amit, Ramos, Alex H., Mermel, Craig H., Tanaka, Kumiko Elisa, Stransky, Nicolas, Greulich, Heidi, Sharifnia, Tanaz, Hammerman, Peter S., Cho, Jeonghee, Chande, Ajit, Gray, Nathanael S., Whitaker College of Health Sciences and Technology, Broad Institute of MIT and Harvard, Harvard University--MIT Division of Health Sciences and Technology, Meyerson, Matthew L., Dutt, Amit, Ramos, Alex H., Mermel, Craig H., Tanaka, Kumiko Elisa, Stransky, Nicolas, Greulich, Heidi, Sharifnia, Tanaz, Hammerman, Peter S., Cho, Jeonghee, Chande, Ajit, and Gray, Nathanael S.

Abstract

Background Squamous cell lung carcinomas account for approximately 25% of new lung carcinoma cases and 40,000 deaths per year in the United States. Although there are multiple genomically targeted therapies for lung adenocarcinoma, none has yet been reported in squamous cell lung carcinoma. Methodology/Principal Findings Using SNP array analysis, we found that a region of chromosome segment 8p11-12 containing three genes–WHSC1L1, LETM2, and FGFR1–is amplified in 3% of lung adenocarcinomas and 21% of squamous cell lung carcinomas. Furthermore, we demonstrated that a non-small cell lung carcinoma cell line harboring focal amplification of FGFR1 is dependent on FGFR1 activity for cell growth, as treatment of this cell line either with FGFR1-specific shRNAs or with FGFR small molecule enzymatic inhibitors leads to cell growth inhibition. Conclusions/Significance These studies show that FGFR1 amplification is common in squamous cell lung cancer, and that FGFR1 may represent a promising therapeutic target in non-small cell lung cancer., Novartis Pharmaceuticals Corporation, American Lung Association, Uniting Against Lung Cancer, Sara Thomas Monopoli Fund, Seaman Foundation, India. Dept. of Biotechnology, National Lung Cancer Partnership

Published
2011

36. Somatic mutation of CDKN1B in small intestine neuroendocrine tumors

Author

Francis, Joshua M, primary, Kiezun, Adam, additional, Ramos, Alex H, additional, Serra, Stefano, additional, Pedamallu, Chandra Sekhar, additional, Qian, Zhi Rong, additional, Banck, Michaela S, additional, Kanwar, Rahul, additional, Kulkarni, Amit A, additional, Karpathakis, Anna, additional, Manzo, Veronica, additional, Contractor, Tanupriya, additional, Philips, Juliet, additional, Nickerson, Elizabeth, additional, Pho, Nam, additional, Hooshmand, Susanne M, additional, Brais, Lauren K, additional, Lawrence, Michael S, additional, Pugh, Trevor, additional, McKenna, Aaron, additional, Sivachenko, Andrey, additional, Cibulskis, Kristian, additional, Carter, Scott L, additional, Ojesina, Akinyemi I, additional, Freeman, Samuel, additional, Jones, Robert T, additional, Voet, Douglas, additional, Saksena, Gordon, additional, Auclair, Daniel, additional, Onofrio, Robert, additional, Shefler, Erica, additional, Sougnez, Carrie, additional, Grimsby, Jonna, additional, Green, Lisa, additional, Lennon, Niall, additional, Meyer, Tim, additional, Caplin, Martyn, additional, Chung, Daniel C, additional, Beutler, Andreas S, additional, Ogino, Shuji, additional, Thirlwell, Christina, additional, Shivdasani, Ramesh, additional, Asa, Sylvia L, additional, Harris, Chris R, additional, Getz, Gad, additional, Kulke, Matthew, additional, and Meyerson, Matthew, additional

Published
2013
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37. Punctuated Evolution of Prostate Cancer Genomes

Author

Baca, Sylvan C., primary, Prandi, Davide, additional, Lawrence, Michael S., additional, Mosquera, Juan Miguel, additional, Romanel, Alessandro, additional, Drier, Yotam, additional, Park, Kyung, additional, Kitabayashi, Naoki, additional, MacDonald, Theresa Y., additional, Ghandi, Mahmoud, additional, Van Allen, Eliezer, additional, Kryukov, Gregory V., additional, Sboner, Andrea, additional, Theurillat, Jean-Philippe, additional, Soong, T. David, additional, Nickerson, Elizabeth, additional, Auclair, Daniel, additional, Tewari, Ashutosh, additional, Beltran, Himisha, additional, Onofrio, Robert C., additional, Boysen, Gunther, additional, Guiducci, Candace, additional, Barbieri, Christopher E., additional, Cibulskis, Kristian, additional, Sivachenko, Andrey, additional, Carter, Scott L., additional, Saksena, Gordon, additional, Voet, Douglas, additional, Ramos, Alex H., additional, Winckler, Wendy, additional, Cipicchio, Michelle, additional, Ardlie, Kristin, additional, Kantoff, Philip W., additional, Berger, Michael F., additional, Gabriel, Stacey B., additional, Golub, Todd R., additional, Meyerson, Matthew, additional, Lander, Eric S., additional, Elemento, Olivier, additional, Getz, Gad, additional, Demichelis, Francesca, additional, Rubin, Mark A., additional, and Garraway, Levi A., additional

Published
2013
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38. Abstract 4017: Dissecting the clonal hierarchy of cancer-driving genomic lesions.

Author

Prandi, Davide, primary, Baca, Sylvan C., additional, Lawrence, Michael S., additional, Mosquera, Juan Miguel, additional, Romanel, Alessandro, additional, Drier, Yotam, additional, Park, Kyung, additional, Kitabayashi, Naoki, additional, MacDonald, Theresa Y., additional, Van Allen, Eliezer, additional, Kryukov, Gregory V., additional, Theurillat, Jean-Philippe, additional, Soong, T. David, additional, Nickerson, Elizabeth, additional, Auclair, Daniel, additional, Tewari, Ashutosh, additional, Beltran, Himisha, additional, Onofrio, Robert C., additional, Boysen, Gunther, additional, Guiducci, Candace, additional, Barbieri, Christopher E., additional, Cibulskis, Kristian, additional, Sivachenko, Andrey, additional, Carter, Scott L., additional, Saksena, Gordon, additional, Voet, Douglas, additional, Ramos, Alex H., additional, Winckler, Wendy, additional, Cipicchio, Michelle, additional, Ardlie, Kristin, additional, Kantoff, Philip W., additional, Berger, Michael F., additional, Gabriel, Stacey B., additional, Golub, Todd R., additional, Meyerson, Matthew, additional, Lander, Eric S., additional, Elemento, Olivier, additional, Getz, Gad, additional, Demichelis, Francesca, additional, Rubin, Mark A., additional, and Garraway, Levi A., additional

Published
2013
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39. Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity

Author

Dulak, Austin M, primary, Stojanov, Petar, additional, Peng, Shouyong, additional, Lawrence, Michael S, additional, Fox, Cameron, additional, Stewart, Chip, additional, Bandla, Santhoshi, additional, Imamura, Yu, additional, Schumacher, Steven E, additional, Shefler, Erica, additional, McKenna, Aaron, additional, Carter, Scott L, additional, Cibulskis, Kristian, additional, Sivachenko, Andrey, additional, Saksena, Gordon, additional, Voet, Douglas, additional, Ramos, Alex H, additional, Auclair, Daniel, additional, Thompson, Kristin, additional, Sougnez, Carrie, additional, Onofrio, Robert C, additional, Guiducci, Candace, additional, Beroukhim, Rameen, additional, Zhou, Zhongren, additional, Lin, Lin, additional, Lin, Jules, additional, Reddy, Rishindra, additional, Chang, Andrew, additional, Landrenau, Rodney, additional, Pennathur, Arjun, additional, Ogino, Shuji, additional, Luketich, James D, additional, Golub, Todd R, additional, Gabriel, Stacey B, additional, Lander, Eric S, additional, Beer, David G, additional, Godfrey, Tony E, additional, Getz, Gad, additional, and Bass, Adam J, additional

Published
2013
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40. The genetic landscape of high-risk neuroblastoma

Author

Pugh, Trevor J, primary, Morozova, Olena, additional, Attiyeh, Edward F, additional, Asgharzadeh, Shahab, additional, Wei, Jun S, additional, Auclair, Daniel, additional, Carter, Scott L, additional, Cibulskis, Kristian, additional, Hanna, Megan, additional, Kiezun, Adam, additional, Kim, Jaegil, additional, Lawrence, Michael S, additional, Lichenstein, Lee, additional, McKenna, Aaron, additional, Pedamallu, Chandra Sekhar, additional, Ramos, Alex H, additional, Shefler, Erica, additional, Sivachenko, Andrey, additional, Sougnez, Carrie, additional, Stewart, Chip, additional, Ally, Adrian, additional, Birol, Inanc, additional, Chiu, Readman, additional, Corbett, Richard D, additional, Hirst, Martin, additional, Jackman, Shaun D, additional, Kamoh, Baljit, additional, Khodabakshi, Alireza Hadj, additional, Krzywinski, Martin, additional, Lo, Allan, additional, Moore, Richard A, additional, Mungall, Karen L, additional, Qian, Jenny, additional, Tam, Angela, additional, Thiessen, Nina, additional, Zhao, Yongjun, additional, Cole, Kristina A, additional, Diamond, Maura, additional, Diskin, Sharon J, additional, Mosse, Yael P, additional, Wood, Andrew C, additional, Ji, Lingyun, additional, Sposto, Richard, additional, Badgett, Thomas, additional, London, Wendy B, additional, Moyer, Yvonne, additional, Gastier-Foster, Julie M, additional, Smith, Malcolm A, additional, Auvil, Jaime M Guidry, additional, Gerhard, Daniela S, additional, Hogarty, Michael D, additional, Jones, Steven J M, additional, Lander, Eric S, additional, Gabriel, Stacey B, additional, Getz, Gad, additional, Seeger, Robert C, additional, Khan, Javed, additional, Marra, Marco A, additional, Meyerson, Matthew, additional, and Maris, John M, additional

Published
2013
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41. Abstract PL07-01: Molecular profiling of breast cancer in Mexico: Identification of novel therapeutic targets through whole genome sequencing analysis.

Author

Banerji, Shantanu, primary, Cibulskis, Kristian, additional, Rangel-Escareño, Claudia, additional, Brown, Kristin K., additional, Carter, Scott L., additional, Frederick, Abbie M., additional, Lawrence, Michael S., additional, Sivachenko, Andrey Y., additional, Sougnez, Carrie, additional, Zou, Lihua, additional, Cortes, Maria L., additional, Fernandez-Lopez, Juan C., additional, Peng, Shouyong, additional, Ardlie, Kristin G., additional, Auclair, Daniel, additional, Bautista-Piña, Veronica, additional, Duke, Fujiko, additional, Francis, Joshua, additional, Jung, Joonil, additional, Maffuz-Aziz, Antonio, additional, Onofrio, Robert C., additional, Parkin, Melissa, additional, Pho, Nam H., additional, Quintanar-Jurado, Valeria, additional, Ramos, Alex H., additional, Rebollar-Vega, Rosa, additional, Rodríguez-Cuevas, Sergio A., additional, Romero-Cordoba, Sandra L., additional, Schumacher, Steven E., additional, Stransky, Nicolas, additional, Thompson, Kristin M., additional, Uribe-Figueroa, Laura, additional, Baselga, Jose, additional, Beroukhim, Rameen, additional, Polyak, Kornelia, additional, Sgroi, Dennis C., additional, Richardson, Andrea L., additional, Jimenez-Sánchez, Gerardo, additional, Lander, Eric S., additional, Gabriel, Stacey B., additional, Garraway, Levi A., additional, Golub, Todd R., additional, Meléndez-Zajgla, Jorge, additional, Toker, Alex, additional, Getz, Gad, additional, Meyerson, Matthew, additional, and Hidalgo-Miranda, Alfredo, additional

Published
2012
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42. Gastrointestinal Adenocarcinomas of the Esophagus, Stomach, and Colon Exhibit Distinct Patterns of Genome Instability and Oncogenesis

Author

Dulak, Austin M., primary, Schumacher, Steven E., additional, van Lieshout, Jasper, additional, Imamura, Yu, additional, Fox, Cameron, additional, Shim, Byoungyong, additional, Ramos, Alex H., additional, Saksena, Gordon, additional, Baca, Sylvan C., additional, Baselga, Jose, additional, Tabernero, Josep, additional, Barretina, Jordi, additional, Enzinger, Peter C., additional, Corso, Giovanni, additional, Roviello, Franco, additional, Lin, Lin, additional, Bandla, Santhoshi, additional, Luketich, James D., additional, Pennathur, Arjun, additional, Meyerson, Matthew, additional, Ogino, Shuji, additional, Shivdasani, Ramesh A., additional, Beer, David G., additional, Godfrey, Tony E., additional, Beroukhim, Rameen, additional, and Bass, Adam J., additional

Published
2012
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43. A Landscape of Driver Mutations in Melanoma

Author

Hodis, Eran, primary, Watson, Ian R., additional, Kryukov, Gregory V., additional, Arold, Stefan T., additional, Imielinski, Marcin, additional, Theurillat, Jean-Philippe, additional, Nickerson, Elizabeth, additional, Auclair, Daniel, additional, Li, Liren, additional, Place, Chelsea, additional, DiCara, Daniel, additional, Ramos, Alex H., additional, Lawrence, Michael S., additional, Cibulskis, Kristian, additional, Sivachenko, Andrey, additional, Voet, Douglas, additional, Saksena, Gordon, additional, Stransky, Nicolas, additional, Onofrio, Robert C., additional, Winckler, Wendy, additional, Ardlie, Kristin, additional, Wagle, Nikhil, additional, Wargo, Jennifer, additional, Chong, Kelly, additional, Morton, Donald L., additional, Stemke-Hale, Katherine, additional, Chen, Guo, additional, Noble, Michael, additional, Meyerson, Matthew, additional, Ladbury, John E., additional, Davies, Michael A., additional, Gershenwald, Jeffrey E., additional, Wagner, Stephan N., additional, Hoon, Dave S.B., additional, Schadendorf, Dirk, additional, Lander, Eric S., additional, Gabriel, Stacey B., additional, Getz, Gad, additional, Garraway, Levi A., additional, and Chin, Lynda, additional

Published
2012
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44. Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

Author

Barbieri, Christopher E, primary, Baca, Sylvan C, additional, Lawrence, Michael S, additional, Demichelis, Francesca, additional, Blattner, Mirjam, additional, Theurillat, Jean-Philippe, additional, White, Thomas A, additional, Stojanov, Petar, additional, Van Allen, Eliezer, additional, Stransky, Nicolas, additional, Nickerson, Elizabeth, additional, Chae, Sung-Suk, additional, Boysen, Gunther, additional, Auclair, Daniel, additional, Onofrio, Robert C, additional, Park, Kyung, additional, Kitabayashi, Naoki, additional, MacDonald, Theresa Y, additional, Sheikh, Karen, additional, Vuong, Terry, additional, Guiducci, Candace, additional, Cibulskis, Kristian, additional, Sivachenko, Andrey, additional, Carter, Scott L, additional, Saksena, Gordon, additional, Voet, Douglas, additional, Hussain, Wasay M, additional, Ramos, Alex H, additional, Winckler, Wendy, additional, Redman, Michelle C, additional, Ardlie, Kristin, additional, Tewari, Ashutosh K, additional, Mosquera, Juan Miguel, additional, Rupp, Niels, additional, Wild, Peter J, additional, Moch, Holger, additional, Morrissey, Colm, additional, Nelson, Peter S, additional, Kantoff, Philip W, additional, Gabriel, Stacey B, additional, Golub, Todd R, additional, Meyerson, Matthew, additional, Lander, Eric S, additional, Getz, Gad, additional, Rubin, Mark A, additional, and Garraway, Levi A, additional

Published
2012
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45. Abstract 4868: Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations within a wide spectrum of genetic heterogeneity

Author

Pugh, Trevor J., primary, Cho, Yoon-Jae, additional, Archer, Tenley, additional, Weeraratne, Dilhan, additional, Jones, David T. W., additional, Jaeger, Natalie, additional, Auclair, Daniel, additional, Cibulskis, Kristian, additional, Lawrence, Michael S., additional, Ramos, Alex H., additional, Shefler, Erica, additional, Sivachenko, Andrey, additional, Tamayo, Pablo, additional, Mesirov, Jill P., additional, Gabriel, Stacey B., additional, Getz, Gad, additional, Pfister, Stefan M., additional, Lichter, Peter, additional, Meyerson, Matthew, additional, and Pomeroy, Scott L., additional

Published
2012
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46. 1314 RECURRENT MUTATIONS IN SPOP DEFINE A DISTINCT MOLECULAR CLASS OF PROSTATE CANCER

Author

Barbieri, Christopher, primary, Baca, Sylvan, additional, Demichelis, Francesca, additional, Lawrence, Michael, additional, Blattner, Mija, additional, Theurillat, Jean-Philippe, additional, Boysen, Gunther, additional, Stojanov, Petar, additional, Van Allen, Eli, additional, Stransky, Nico, additional, Nickerson, Elizabeth, additional, Park, Kyung, additional, Kitabayashi, Naoki, additional, MacDonald, Theresa, additional, Vuong, Terry, additional, Auclair, Daniel, additional, Onofrio, Robert, additional, Guiducci, Candace, additional, Cibulskis, Kristian, additional, Sivachenko, Andrey, additional, Carter, Scott, additional, Ambrogio, Lauren, additional, Parkin, Melissa, additional, White, Thomas, additional, Saksena, Gordon, additional, Voet, Douglas, additional, Ramos, Alex H., additional, Winckler, Wendy, additional, Hussain, Wasay, additional, Wilkinson, Jane, additional, Ardlie, Kristin, additional, Banerjee, Samprit, additional, Baldwin, Jennifer, additional, Mosquera, Juan Miguel, additional, Gabriel, Stacey B., additional, Kantoff, Philip W., additional, Golub, Todd R., additional, Meyerson, Matthew, additional, Lander, Eric S., additional, Getz, Gad, additional, Nelson, Peter, additional, Garraway, Levi A., additional, Tewari, Ashutosh, additional, and Rubin, Mark A., additional

Published
2012
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47. Abstract 5056: A glimpse into the somatic mutation landscape of melanoma through exome sequencing of 121 tumor-normal pairs

Author

Hodis, Eran, primary, Watson, Ian, additional, Theurillat, Jean-Philippe, additional, Zou, Lihua, additional, Place, Chelsea, additional, Nickerson, Elizabeth, additional, Auclair, Daniel, additional, Cibulskis, Kristian, additional, Sivachenko, Andrey, additional, Kryukov, Gregory, additional, Stransky, Nicolas, additional, Ramos, Alex H., additional, Voet, Douglas, additional, Lawrence, Michael S., additional, Stojanov, Petar, additional, Saksena, Gordon, additional, McKenna, Aaron, additional, Carter, Scott L., additional, Pugh, Trevor, additional, Noble, Michael, additional, Lin, Pei, additional, Lichtenstein, Lee, additional, Zupko, Robert, additional, Sougnez, Carrie, additional, Guiducci, Candace, additional, Onofrio, Robert C., additional, Ambrogio, Lauren, additional, Fennell, Timothy, additional, Chong, Kelly, additional, Winckler, Wendy, additional, Ardlie, Kristin, additional, Lander, Eric S., additional, Golub, Todd, additional, Meyerson, Matthew, additional, Gabriel, Stacey B., additional, Getz, Gad, additional, Wagner, Stefan, additional, Schadendorf, Dirk, additional, Hoon, Dave S. B., additional, Chin, Lynda, additional, and Garraway, Levi A., additional

Published
2012
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48. Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion

Author

Bass, Adam J, primary, Lawrence, Michael S, additional, Brace, Lear E, additional, Ramos, Alex H, additional, Drier, Yotam, additional, Cibulskis, Kristian, additional, Sougnez, Carrie, additional, Voet, Douglas, additional, Saksena, Gordon, additional, Sivachenko, Andrey, additional, Jing, Rui, additional, Parkin, Melissa, additional, Pugh, Trevor, additional, Verhaak, Roel G, additional, Stransky, Nicolas, additional, Boutin, Adam T, additional, Barretina, Jordi, additional, Solit, David B, additional, Vakiani, Evi, additional, Shao, Wenlin, additional, Mishina, Yuji, additional, Warmuth, Markus, additional, Jimenez, Jose, additional, Chiang, Derek Y, additional, Signoretti, Sabina, additional, Kaelin, William G, additional, Spardy, Nicole, additional, Hahn, William C, additional, Hoshida, Yujin, additional, Ogino, Shuji, additional, DePinho, Ronald A, additional, Chin, Lynda, additional, Garraway, Levi A, additional, Fuchs, Charles S, additional, Baselga, Jose, additional, Tabernero, Josep, additional, Gabriel, Stacey, additional, Lander, Eric S, additional, Getz, Gad, additional, and Meyerson, Matthew, additional

Published
2011
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49. Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer

Author

Dutt, Amit, primary, Ramos, Alex H., additional, Hammerman, Peter S., additional, Mermel, Craig, additional, Cho, Jeonghee, additional, Sharifnia, Tanaz, additional, Chande, Ajit, additional, Tanaka, Kumiko Elisa, additional, Stransky, Nicolas, additional, Greulich, Heidi, additional, Gray, Nathanael S., additional, and Meyerson, Matthew, additional

Published
2011
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50. Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer

Author

Hammerman, Peter S., primary, Sos, Martin L., additional, Ramos, Alex H., additional, Xu, Chunxiao, additional, Dutt, Amit, additional, Zhou, Wenjun, additional, Brace, Lear E., additional, Woods, Brittany A., additional, Lin, Wenchu, additional, Zhang, Jianming, additional, Deng, Xianming, additional, Lim, Sang Min, additional, Heynck, Stefanie, additional, Peifer, Martin, additional, Simard, Jeffrey R., additional, Lawrence, Michael S., additional, Onofrio, Robert C., additional, Salvesen, Helga B., additional, Seidel, Danila, additional, Zander, Thomas, additional, Heuckmann, Johannes M., additional, Soltermann, Alex, additional, Moch, Holger, additional, Koker, Mirjam, additional, Leenders, Frauke, additional, Gabler, Franziska, additional, Querings, Silvia, additional, Ansén, Sascha, additional, Brambilla, Elisabeth, additional, Brambilla, Christian, additional, Lorimier, Philippe, additional, Brustugun, Odd Terje, additional, Helland, Åslaug, additional, Petersen, Iver, additional, Clement, Joachim H., additional, Groen, Harry, additional, Timens, Wim, additional, Sietsma, Hannie, additional, Stoelben, Erich, additional, Wolf, Jürgen, additional, Beer, David G., additional, Tsao, Ming Sound, additional, Hanna, Megan, additional, Hatton, Charles, additional, Eck, Michael J., additional, Janne, Pasi A., additional, Johnson, Bruce E., additional, Winckler, Wendy, additional, Greulich, Heidi, additional, Bass, Adam J., additional, Cho, Jeonghee, additional, Rauh, Daniel, additional, Gray, Nathanael S., additional, Wong, Kwok-Kin, additional, Haura, Eric B., additional, Thomas, Roman K., additional, and Meyerson, Matthew, additional

Published
2011
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