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1. Improved Pregnancy Outcome in Patients With Rheumatoid Arthritis Who Followed an Ideal Clinical Pathway

Author

Bortoluzzi, A, Andreoli, L, Carrara, G, Ramoni, V, Rumi, F, Padovan, M, Govoni, M, Tincani, A, Scire, C, Bortoluzzi A., Andreoli L., Carrara G., Ramoni V., Rumi F., Padovan M., Govoni M., Tincani A., Scire C. A., Bortoluzzi, A, Andreoli, L, Carrara, G, Ramoni, V, Rumi, F, Padovan, M, Govoni, M, Tincani, A, Scire, C, Bortoluzzi A., Andreoli L., Carrara G., Ramoni V., Rumi F., Padovan M., Govoni M., Tincani A., and Scire C. A.

Abstract

Objective: To assess the effect of optimal management of pregnancy on a composite outcome of miscarriage and complicated birth among women with rheumatoid arthritis (RA). Methods: Data were extracted from health care databases of the Lombardy Region, Italy (2004–2013) as a part of the Record-Linkage on Rheumatic Diseases Study. Analyses included women with RA identified through a copayment exemption code (International Classification of Diseases, Ninth Revision, Clinical Modification code 714.0) and controls from the general population, ages 18–50 years. Seven health care quality indicators (HCQI) were constructed and summarized in 3 pathway indicators: diagnostic, therapeutic, and prenatal follow-up. Complicated birth or miscarriage were used to identify the adverse pregnancy outcome (APO). The relationship between HCQI and APO was analyzed using logistic models, and the results were presented as odds ratios (ORs) and 95% confidence intervals (95% CIs). Results: Data from the study cohort included the first pregnancy observed in 443 patients with RA compared with 6,097 women belonging to the general population. In the RA population, patients who followed the 3 pathway indicators had a reduced risk of overall APO, with an OR of 0.60 (95% CI 0.39–0.94), and reduced risk of miscarriage/perinatal death, with an OR of 0.40 (95% CI 0.24–0.69), compared to those who did not follow the pathway indicators. Compared with the general population, patients with RA who met all HCQI during pregnancy displayed a risk of APO with an OR of 0.92 (95% CI 0.61–1.38) and miscarriage/perinatal death with an OR of 0.77 (95% CI 0.47–1.29). Conclusion: The adherence to an ideal clinical pathway of pregnancy management in women with RA restored the risk of APO to that expected for the general population.

Published
2021

3. POS0741 REPORT FROM THE APS STUDY GROUP OF THE ITALIAN SOCIETY FOR RHEUMATOLOGY (SIR-APS) ON aPL NEGATIVIZATION

Author

Foddai, S. G., primary, Sciascia, S., additional, Alessandri, C., additional, Alunno, A., additional, Andreoli, L., additional, Barinotti, A., additional, Calligaro, A., additional, Canti, V., additional, Carubbi, F., additional, Cecchi, I., additional, Chighizola, C., additional, Conti, F., additional, Emmi, G., additional, Fioravanti, A., additional, Fischetti, F., additional, Franceschini, F., additional, Gerosa, M., additional, Hoxha, A., additional, Larosa, M., additional, Lazzaroni, M. G., additional, Nalli, C., additional, Pazzola, G., additional, Radin, M., additional, Raffeiner, B., additional, Ramoni, V., additional, Roccatello, D., additional, Rubini, E., additional, Sebastiani, G., additional, Truglia, S., additional, Urban, M. L., additional, and Tincani, A., additional

Published
2022
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4. OP0125 THE MANAGEMENT OF PREGNANCY IN AUTOIMMUNE RHEUMATIC DISEASES: ANALYSIS OF 758 PREGNANCIES FROM THE PROSPECTIVE NATIONWIDE P-RHEUM.IT STUDY (THE ITALIAN REGISTRY OF PREGNANCY IN THE RHEUMATIC DISEASES)

Author

Andreoli, L., primary, Gerardi, M. C., additional, Crisafulli, F., additional, Zanetti, A., additional, Rozza, D., additional, Gerosa, M., additional, Lini, D., additional, Filippini, M., additional, Fredi, M., additional, Nalli, C., additional, Lazzaroni, M. G., additional, Taglietti, M., additional, Franceschini, F., additional, Caporali, R., additional, Trespidi, L., additional, Erra, R., additional, Mosca, M., additional, Tani, C., additional, Zucchi, D., additional, Melissa, P., additional, Ruffilli, F., additional, Maranini, B., additional, Rovere-Querini, P., additional, Canti, V., additional, De Lorenzo, R., additional, Cutro, M. S., additional, Picerno, V., additional, Montecucco, C., additional, Ramoni, V., additional, Anelli, M. G., additional, Abbruzzese, A., additional, Serale, F., additional, Romeo, N., additional, Chimenti, M. S., additional, Cuomo, G., additional, Larosa, M., additional, Pata, A. P., additional, Iuliano, A., additional, Crepaldi, G., additional, Brucato, A., additional, Landolfi, G., additional, Carrara, G., additional, Bortoluzzi, A., additional, Scirè, C. A., additional, and Tincani, A., additional

Published
2022
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5. Anti-SSA/Ro positivity and congenital heart block: obstetric and foetal outcome in a cohort of anti-SSA/Ro positive pregnant patients with and without autoimmune diseases

Author

Fredi, M, Argolini, Lm, Angeli, F, Trespidi, L, Ramoni, V, Zatti, S, Vojinovic, T, Donzelli, D, Gazzola, Fg, Xoxi, B, Andreoli, L, Lojacono, A, Ferrazzi, E, Montecucco, C, Chighizola, Cb, Meroni, Pl, Franceschini, F, Cimaz, R, Caporali, R, Tincani, A, and Gerosa, M

Subjects
Rheumatology, Immunology, Immunology and Allergy
Abstract

Neonatal lupus (NL) is an acquired disease caused by the transplacental passage of anti-SSA/Ro antibodies. The rate of congenital heart block (CHB), its most serious manifestation, ranges from 1 to 5%. The aim of this study was to retrospectively assess the prevalence of CHB in anti-SSA/Ro positive pregnant women with or without systemic autoimmune diseases from 2010 to 2020.Patients underwent monthly visit and a shared follow-up programme of weekly (16th-24th week) foetal heart rate assessment by obstetric ultrasound.322 pregnancies in 258 anti-SSA/Ro patients were included; 314 were followed from the beginning of pregnancy because of the known presence of anti-SSA/Ro autoantibodies and 1 case of CHB occurred in an anti-SSA/Ro+ asymptomatic subject (0.3%). In the same period, 8 additional patients were referred to our clinics after in utero CHB diagnosis and subsequent discovery of anti-SSA/Ro without a disease diagnosis. Globally, 9 cases of congenital CHB (2.8%) occurred: 7 complete, 1 II-III degree and 1 rst degree CHB. Anti-SSB/La positivity was associated with a higher risk of CHB (7.8% vs. 1.2%; p=0.0071). No differences in maternal or foetal outcomes were found in comparison with a large cohort of unselected pregnancies except for caesarian section. Hydroxychloroquine (HCQ) was used in 58.3% pregnancies, with a different prevalence according with maternal diagnosis.Our data suggest that anti-SSA/Ro positive patents with a de ned systemic autoimmune disease undergoing a strict follow-up since positive pregnancy test display a low risk of pregnancy complications, including but not limited to NL.

Published
2022

7. Clinical Delphi on aPLnegativization: report from the from the APS Study Group of the Italian Society for Rheumatology (SIR-APS)

Author

Sciascia, S, Foddai, Sg, Alessandri, C, Alunno, A, Andreli, L, Barinotti, A, Calligaro, A, Canti, V, Carubbi, F, Cecchi, I, Chighizola, Cb, Conti, F, Emmi, G, Fioravanti, A, Fischetti, F, Franceschini, F, Gerosa, M, Hoxha, A, Larosa, M, Lazzaroni, Mg, Nalli, C, Pazzola, G, Radin, M, Raffeiner, B, Ramoni, V, Rubini, E, Sebastiani, Gd, Truglia, S, Urban, Ml, Roccatello, D, and Tincani, A.

Published
2022

8. Undifferentiated connective tissue disease: State of the art on clinical practice guidelines

Author

Antunes, M, Scire, C, Talarico, R, Alexander, T, Avcin, T, Belocchi, C, Doria, A, Franceschini, F, Galetti, I, Govoni, M, Hachulla, E, Launay, D, Lepri, G, Macieira, C, Matucci-Cerinic, M, Montecucco, C, Moraes-Fontes, M, Mouthon, L, Paolino, S, Ramoni, V, Tani, C, Tas, S, Tincani, A, Van Vollenhoven, R, Zen, M, Fonseca, J, Bombardieri, S, Schneider, M, Smith, V, Cutolo, M, Mosca, M, Beretta, L, Antunes M., Scire C. A., Talarico R., Alexander T., Avcin T., Belocchi C., Doria A., Franceschini F., Galetti I., Govoni M., Hachulla E., Launay D., Lepri G., Macieira C., Matucci-Cerinic M., Montecucco C. M., Moraes-Fontes M. F., Mouthon L., Paolino S., Ramoni V., Tani C., Tas S. W., Tincani A., Van Vollenhoven R., Zen M., Fonseca J., Bombardieri S., Fonseca J. E., Schneider M., Smith V., Cutolo M., Mosca M., Beretta L., Antunes, M, Scire, C, Talarico, R, Alexander, T, Avcin, T, Belocchi, C, Doria, A, Franceschini, F, Galetti, I, Govoni, M, Hachulla, E, Launay, D, Lepri, G, Macieira, C, Matucci-Cerinic, M, Montecucco, C, Moraes-Fontes, M, Mouthon, L, Paolino, S, Ramoni, V, Tani, C, Tas, S, Tincani, A, Van Vollenhoven, R, Zen, M, Fonseca, J, Bombardieri, S, Schneider, M, Smith, V, Cutolo, M, Mosca, M, Beretta, L, Antunes M., Scire C. A., Talarico R., Alexander T., Avcin T., Belocchi C., Doria A., Franceschini F., Galetti I., Govoni M., Hachulla E., Launay D., Lepri G., Macieira C., Matucci-Cerinic M., Montecucco C. M., Moraes-Fontes M. F., Mouthon L., Paolino S., Ramoni V., Tani C., Tas S. W., Tincani A., Van Vollenhoven R., Zen M., Fonseca J., Bombardieri S., Fonseca J. E., Schneider M., Smith V., Cutolo M., Mosca M., and Beretta L.

Abstract

The term a € undifferentiated connective tissue disease' (UCTD) is generally used to describe clinical entities characterised by clinical and serological manifestations of systemic autoimmune diseases but not fulfilling the criteria for defined connective tissue diseases (CTDs). In this narrative review, we summarise the results of a systematic literature research, which was performed as part of the ERN ReCONNET project, aimed at evaluating existing clinical practice guidelines (CPGs) or recommendations. No specific CPG on UCTD were found, potential areas of intervention are absence of a consensus definition of UCTD, need for specific monitoring and therapeutic protocols, stratification of UCTD based on the risk of developing a defined CTD and preventive measure for the future development of a more severe condition. Patients feel uncertainty regarding the name of the disease and feel the need of a better education and understanding of these conditions and its possible changes over time.

Published
2019

9. Disease activity assessment of rheumatic diseases during pregnancy: a comprehensive review of indices used in clinical studies

Author

Andreoli, L, Gerardi, M, Fernandes, M, Bortoluzzi, A, Bellando-Randone, S, Brucato, A, Caporali, R, Chighizola, C, Chimenti, M, Conigliaro, P, Cutolo, M, Cutro, M, D'Angelo, S, Doria, A, Elefante, E, Fredi, M, Galeazzi, M, Gerosa, M, Govoni, M, Iuliano, A, Larosa, M, Lazzaroni, M, Matucci-Cerinic, M, Meroni, M, Meroni, P, Mosca, M, Patane, M, Pazzola, G, Pendolino, M, Perricone, R, Ramoni, V, Salvarani, C, Sebastiani, G, Selmi, C, Spinelli, F, Valesini, G, Scire, C, Tincani, A, Andreoli L., Gerardi M. C., Fernandes M., Bortoluzzi A., Bellando-Randone S., Brucato A., Caporali R., Chighizola C. B., Chimenti M. S., Conigliaro P., Cutolo M., Cutro M. S., D'Angelo S., Doria A., Elefante E., Fredi M., Galeazzi M., Gerosa M., Govoni M., Iuliano A., Larosa M., Lazzaroni M. G., Matucci-Cerinic M., Meroni M., Meroni P. L., Mosca M., Patane M., Pazzola G., Pendolino M., Perricone R., Ramoni V., Salvarani C., Sebastiani G. D., Selmi C., Spinelli F. R., Valesini G., Scire C. A., Tincani A., Andreoli, L, Gerardi, M, Fernandes, M, Bortoluzzi, A, Bellando-Randone, S, Brucato, A, Caporali, R, Chighizola, C, Chimenti, M, Conigliaro, P, Cutolo, M, Cutro, M, D'Angelo, S, Doria, A, Elefante, E, Fredi, M, Galeazzi, M, Gerosa, M, Govoni, M, Iuliano, A, Larosa, M, Lazzaroni, M, Matucci-Cerinic, M, Meroni, M, Meroni, P, Mosca, M, Patane, M, Pazzola, G, Pendolino, M, Perricone, R, Ramoni, V, Salvarani, C, Sebastiani, G, Selmi, C, Spinelli, F, Valesini, G, Scire, C, Tincani, A, Andreoli L., Gerardi M. C., Fernandes M., Bortoluzzi A., Bellando-Randone S., Brucato A., Caporali R., Chighizola C. B., Chimenti M. S., Conigliaro P., Cutolo M., Cutro M. S., D'Angelo S., Doria A., Elefante E., Fredi M., Galeazzi M., Gerosa M., Govoni M., Iuliano A., Larosa M., Lazzaroni M. G., Matucci-Cerinic M., Meroni M., Meroni P. L., Mosca M., Patane M., Pazzola G., Pendolino M., Perricone R., Ramoni V., Salvarani C., Sebastiani G. D., Selmi C., Spinelli F. R., Valesini G., Scire C. A., and Tincani A.

Abstract

Pregnancy requires a special management in women with inflammatory rheumatic diseases (RDs), with the aim of controlling maternal disease activity and avoiding fetal complications. Despite the heterogeneous course of RDs during pregnancy, their impact on pregnancy largely relates to the extent of active inflammation at the time of conception. Therefore, accurate evaluation of disease activity is crucial for the best management of pregnant patients. Nevertheless, there are limitations in using conventional measures of disease activity in pregnancy, as some items included in these instruments can be biased by symptoms or by physiological changes related to pregnancy and the pregnancy itself may influence laboratory parameters used to assess disease activity. This article aims to summarize the current literature about the available instruments to measure disease activity during pregnancy in RDs. Systemic lupus erythematosus is the only disease with instruments that have been modified to account for several adaptations which might interfere with the attribution of signs or symptoms to disease activity during pregnancy. No modified-pregnancy indices exist for women affected by other RDs, but standard indices have been applied to pregnant patients. The current body of knowledge shows that the physiologic changes that occur during pregnancy need to be either adapted from existing instruments or developed to improve the management of pregnant women with RDs. Standardized instruments to assess disease activity during pregnancy would be helpful not only for clinical practice but also for research purposes.

Published
2019

10. POS0751 COMORBIDITY AND LONG-TERM OUTCOME IN PATIENTS WITH CONGENITAL HEART BLOCK: PRELIMINARY DATA OF THE ITALIAN REGISTRY ON THE IMMUNE-MEDIATED CONGENITAL HEART BLOCK

Author

Fredi, M., primary, Rizzo, G., additional, Andreoli, L., additional, Bacco, B., additional, Bertero, T., additional, Bortoluzzi, A., additional, Ceccarelli, F., additional, Cimaz, R., additional, Conigliaro, P., additional, Corradi, F., additional, De Vita, S., additional, DI Poi, E., additional, Elefante, E., additional, Emmi, G., additional, Gerosa, M., additional, Govoni, M., additional, Hoxha, A., additional, Lojacono, A., additional, Marrani, E., additional, Marozio, L., additional, Mathieu, A., additional, Mosca, M., additional, Melissa, P., additional, Picchi, C., additional, Piga, M., additional, Priori, R., additional, Ramoni, V., additional, Ruffatti, A., additional, Simonini, G., additional, Tani, C., additional, Tonello, M., additional, Trespidi, L., additional, Urban, M. L., additional, Vezzoli, M., additional, Zatti, S., additional, Calza, S., additional, Brucato, A., additional, Franceschini, F., additional, and Tincani, A., additional

Published
2021
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12. Antiphospholipid syndrome: State of the art on clinical practice guidelines

Author

Limper, M, Scire, C, Talarico, R, Amoura, Z, Avcin, T, Basile, M, Burmester, G, Carli, L, Cervera, R, Costedoat-Chalumeau, N, Doria, A, Dorner, T, Fonseca, J, Galetti, I, Hachulla, E, Launay, D, Lourenco, F, Macieira, C, Meroni, P, Montecucco, C, Moraes-Fontes, M, Mouthon, L, Nalli, C, Ramoni, V, Tektonidou, M, Van Laar, J, Bombardieri, S, Schneider, M, Smith, V, Vieira, A, Cutolo, M, Mosca, M, Tincani, A, Limper M., Scire C. A., Talarico R., Amoura Z., Avcin T., Basile M., Burmester G., Carli L., Cervera R., Costedoat-Chalumeau N., Doria A., Dorner T., Fonseca J. E., Galetti I., Hachulla E., Launay D., Lourenco F., Macieira C., Meroni P., Montecucco C. M., Moraes-Fontes M. F., Mouthon L., Nalli C., Ramoni V., Tektonidou M., Van Laar J. M., Bombardieri S., Schneider M., Smith V., Vieira A., Cutolo M., Mosca M., Tincani A., Limper, M, Scire, C, Talarico, R, Amoura, Z, Avcin, T, Basile, M, Burmester, G, Carli, L, Cervera, R, Costedoat-Chalumeau, N, Doria, A, Dorner, T, Fonseca, J, Galetti, I, Hachulla, E, Launay, D, Lourenco, F, Macieira, C, Meroni, P, Montecucco, C, Moraes-Fontes, M, Mouthon, L, Nalli, C, Ramoni, V, Tektonidou, M, Van Laar, J, Bombardieri, S, Schneider, M, Smith, V, Vieira, A, Cutolo, M, Mosca, M, Tincani, A, Limper M., Scire C. A., Talarico R., Amoura Z., Avcin T., Basile M., Burmester G., Carli L., Cervera R., Costedoat-Chalumeau N., Doria A., Dorner T., Fonseca J. E., Galetti I., Hachulla E., Launay D., Lourenco F., Macieira C., Meroni P., Montecucco C. M., Moraes-Fontes M. F., Mouthon L., Nalli C., Ramoni V., Tektonidou M., Van Laar J. M., Bombardieri S., Schneider M., Smith V., Vieira A., Cutolo M., Mosca M., and Tincani A.

Abstract

Antiphospholipid syndrome (APS) is a rare disease characterised by venous and/or arterial thrombosis, pregnancy complications and the presence of specific autoantibodies called antiphospholipid antibodies. This review aims to identify existing clinical practice guidelines (CPG) as part of the ERN ReCONNET project, aimed at evaluating existing CPGs or recommendations in rare and complex diseases. Seventeen papers providing important data were identified; however, the literature search highlighted the scarceness of reliable clinical data to develop CPGs. With no formal clinical guidelines in place, diagnosis and treatment of APS is largely based on consensus and expert opinion. Patients' unmet need refers to the understanding of the disease and its clinical picture and implications, the need of education for patients, family members and healthcare providers, as well as to the development of monitoring pathways involving multiple healthcare providers.

Published
2018

15. SAT0207 ANTI-SSA/RO POSITIVITY AND CONGENITAL HEART BLOCK: OBSTETRIC AND FETAL OUTCOME IN A COHORT OF ANTI-SSA/RO POSITIVE PREGNANT WOMEN WITH AND WITHOUT AUTO-IMMUNE DISEASES FROM THREE ITALIAN TERTIARY REFERRAL CENTERS

Author

Gerosa, M., primary, Fredi, M., additional, Andreoli, L., additional, Chighizola, C., additional, Argolini, L. M., additional, Donzelli, D., additional, Vojinovic, T., additional, Ramoni, V., additional, Bellis, E., additional, Trespidi, L., additional, Gazzola, F., additional, Ferrazzi, E., additional, Zatti, S., additional, Benvenuti, F., additional, Meroni, P. L., additional, Franceschini, F., additional, Montecucco, C., additional, Cimaz, R., additional, Caporali, R., additional, and Tincani, A., additional

Published
2020
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18. Antiphospholipid syndrome: State of the art on clinical practice guidelines

Author

Limper, M. Scirè, C.A. Talarico, R. Amoura, Z. Avcin, T. Basile, M. Burmester, G. Carli, L. Cervera, R. Costedoat-Chalumeau, N. Doria, A. Dörner, T. Fonseca, J.E. Galetti, I. Hachulla, E. Launay, D. Lourenco, F. Macieira, C. Meroni, P. Montecucco, C.M. Moraes-Fontes, M.F. Mouthon, L. Nalli, C. Ramoni, V. Tektonidou, M. Van Laar, J.M. Bombardieri, S. Schneider, M. Smith, V. Vieira, A. Cutolo, M. Mosca, M. Tincani, A.

Abstract

Antiphospholipid syndrome (APS) is a rare disease characterised by venous and/or arterial thrombosis, pregnancy complications and the presence of specific autoantibodies called antiphospholipid antibodies. This review aims to identify existing clinical practice guidelines (CPG) as part of the ERN ReCONNET project, aimed at evaluating existing CPGs or recommendations in rare and complex diseases. Seventeen papers providing important data were identified; however, the literature search highlighted the scarceness of reliable clinical data to develop CPGs. With no formal clinical guidelines in place, diagnosis and treatment of APS is largely based on consensus and expert opinion. Patients' unmet need refers to the understanding of the disease and its clinical picture and implications, the need of education for patients, family members and healthcare providers, as well as to the development of monitoring pathways involving multiple healthcare providers. © 2018 Author(s) (or their employer(s)).

Published
2018

21. FRI0373 Long-term follow-up of 320 children born to mothers with systemic autoimmune diseases: a multicentre italian survey from 24 rheumatology centres

Author

Lazzaroni, M.G., primary, Nalli, C., additional, Andreoli, L., additional, Carini, C., additional, Bartoloni-Bocci, E., additional, Gerli, R., additional, Chighizola, C.B., additional, Gerosa, M., additional, Meroni, P.L., additional, Sinigaglia, L., additional, Conigliaro, P., additional, Perricone, R., additional, Corrado, A., additional, Cantatore, F., additional, D’Angelo, S., additional, Favaro, M., additional, Larosa, M., additional, Doria, A., additional, Ruffatti, A., additional, Generali, E., additional, Selmi, C., additional, Meroni, M., additional, Cutolo, M., additional, Padovan, M., additional, Govoni, M., additional, Pazzola, G., additional, Salvarani, C., additional, Peccatori, S., additional, Paolazzi, G., additional, Prevete, I., additional, Sebastiani, G.D., additional, Minisola, G., additional, Brucato, A., additional, Ramoni, V., additional, Caporali, R., additional, Montecucco, C., additional, Tani, C., additional, Signorini, V., additional, Mosca, M., additional, Trevisani, M., additional, Malavolta, N., additional, Vadacca, M., additional, Afeltra, A., additional, Vivaldelli, E., additional, Maier, A., additional, Visalli, E., additional, Foti, R., additional, Zuliani, L., additional, Gabrielli, A., additional, Campochiaro, C., additional, Baldissera, E., additional, Sabbadini, M.G., additional, Romeo, N., additional, and Tincani, A., additional

Published
2018
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22. SAT0448 Report of 86 cases of congenital heart block: data from the italian registry (LU.NE REGISTRY)

Author

Fredi, M., primary, Andreoli, L., additional, Bertero, T., additional, Bortoluzzi, A., additional, Breda, S., additional, Cappa, V., additional, Ceccarelli, F., additional, Cimaz, R., additional, Franceschini, F., additional, Gerosa, M., additional, Govoni, M., additional, Hoxha, A., additional, Lojacono, A., additional, Marozio, L., additional, Mathieu, A., additional, Minniti, A., additional, Muscarà, M., additional, Padovan, M., additional, Piga, M., additional, Priori, R., additional, Ramoni, V., additional, Ruffatti, A., additional, Tonello, M., additional, Zatti, S., additional, Calza, S., additional, Brucato, A., additional, and Tincani, A., additional

Published
2018
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23. PS4:79 Long-term follow-up of 320 chilren born to mothers with systemic autoimmune diseases: a multicentre survey from 24 rheumatology centres in italy

Author

Lazzaroni, MG, primary, Nalli, C, additional, Andreoli, L, additional, Carini, C, additional, Dall’Ara, F, additional, Rodrigues, M, additional, Bartoloni Bocci, E, additional, Gerli, R, additional, Chighizola, CB, additional, Gerosa, M, additional, Meroni, PL, additional, Sinigaglia, L, additional, Conigliaro, P, additional, Perricone, R, additional, Corrado, A, additional, Cantatore, F, additional, D’Angelo, S, additional, Favaro, M, additional, Larosa, M, additional, Doria, A, additional, Ruffatti, A, additional, Generali, E, additional, Selmi, C, additional, Meroni, M, additional, Cutolo, M, additional, Padovan, M, additional, Govoni, M, additional, Pazzola, G, additional, Salvarani, C, additional, Peccatori, S, additional, Prevete, I, additional, Minisola, G, additional, Sebastiani, GD, additional, Brucato, A, additional, Ramoni, V, additional, Caporali, R, additional, Montecucco, C, additional, Tani, C, additional, Signorini, V, additional, Mosca, M, additional, Trevisani, M, additional, Malavolta, N, additional, Vadacca, M, additional, Afeltra, A, additional, Vivaldelli, E, additional, Maier, A, additional, Visalli, E, additional, Foti, R, additional, Zuliani, L, additional, Gabrielli, A, additional, Campochiaro, C, additional, Baldissera, E, additional, Sabbadini, MG, additional, Romeo, N, additional, and Tincani, A, additional

Published
2018
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24. Impress 2 (International multicentric prospective study on pregnancy in systemic sclerosis). Prospective, case-control study of pregnancy in systemic sclerosis

Author

Betelli, M., Ramoni, V., Meroni, M., Allanore, Y., Baresic, M., Beneventi, F., Caramaschi, P., Cutolo, M., Favaro, M., Govoni, M., Hachulla, E., Limonta, M., Matucci Cerinic, M., Riccieri, Valeria, Rosato, Edoardo, Salsano, Felice, Scolack, M., Smith, V., Taraborelli, M., Tincani, A., Valentini, G., Vonk, M., and Brucato, A.

Subjects
case control, systemic sclerosis, pregnancy
Published
2016

25. AB1099 Counselling on family planning and contraception, and pregnancy outcome in women with rheumatic diseases: a national survey of 398 patient-reported questionnaires from 24 rheumatology centers

Author

Lazzaroni, MG, primary, Dall'Ara, F, additional, Andreoli, L, additional, Carini, C, additional, Rodrigues, M, additional, Reggia, R, additional, Bartoloni-Bocci, E, additional, Gerli, R, additional, Chighizola, CB, additional, Gerosa, M, additional, Meroni, PL, additional, Sinigaglia, L, additional, Conigliaro, P, additional, Perricone, R, additional, Corrado, A, additional, Cantatore, FP, additional, D'Angelo, S, additional, Olivieri, I, additional, Favaro, M, additional, Doria, A, additional, Ruffatti, A, additional, Generali, E, additional, Selmi, C, additional, Meroni, M, additional, Cutolo, M, additional, Padovan, M, additional, Govoni, M, additional, Pazzola, G, additional, Salvarani, C, additional, Peccatori, S, additional, Paolazzi, G, additional, Prevete, I, additional, Sebastiani, GD, additional, Minisola, G, additional, Brucato, A, additional, Ramoni, V, additional, Caporali, R, additional, Montecucco, C, additional, Tani, C, additional, Mosca, M, additional, Trevisani, M, additional, Malavolta, N, additional, Vadacca, M, additional, Afeltra, A, additional, Vivaldelli, E, additional, Maier, A, additional, Baldissera, E, additional, Visalli, E, additional, Foti, R, additional, Zuliani, L, additional, Gabrielli, A, additional, Romeo, N, additional, and Tincani, A, additional

Published
2017
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26. AB0467 Efficacy and safety of assisted reproductive technologies (ART) in rheumatic patients: a multicenter study

Author

Reggia, R, primary, Sebbar, H, additional, Andreoli, L, additional, Hoxha, A, additional, Larosa, M, additional, Ceccarelli, F, additional, Canti, V, additional, Ramoni, V, additional, Inversetti, A, additional, Ruffatti, A, additional, Doria, A, additional, Conti, F, additional, Valesini, G, additional, Querini, P Rovere, additional, Montecucco, C, additional, Lojacono, A, additional, Fallo, L, additional, and Tincani, A, additional

Published
2017
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28. THU0611 Long-term follow-up of 269 children born to mothers with systemic autoimmune diseases: a national survey from 24 rheumatology centers

Author

Nalli, C, primary, Andreoli, L, additional, Carini, C, additional, Rodrigues, M, additional, Dall'Ara, F, additional, Lazzaroni, MG, additional, Bartoloni-Bocci, E, additional, Chighizola, CB, additional, Campochiaro, C, additional, Conigliaro, P, additional, Corrado, A, additional, D'Angelo, S, additional, Favaro, M, additional, Generali, E, additional, Gerosa, M, additional, Larosa, M, additional, Meroni, M, additional, Padovan, M, additional, Pazzola, G, additional, Peccatori, S, additional, Prevete, I, additional, Ramoni, V, additional, Sebastiani, G, additional, Signorini, V, additional, Tani, C, additional, Trevisani, M, additional, Vadacca, M, additional, Vivaldelli, E, additional, Visalli, E, additional, Zuliani, L, additional, Afeltra, A, additional, Baldissera, E, additional, Brucato, A, additional, Cantatore, FP, additional, Caporali, R, additional, Cutolo, M, additional, Doria, A, additional, Foti, R, additional, Gabrielli, A, additional, Gerli, R, additional, Govoni, M, additional, Maier, A, additional, Malavolta, N, additional, Meroni, PL, additional, Minisola, G, additional, Montecucco, CM, additional, Mosca, M, additional, Olivieri, I, additional, Paolazzi, G, additional, Perricone, R, additional, Romeo, N, additional, Ruffatti, A, additional, Sabbadini, MG, additional, Salvarani, C, additional, Selmi, C, additional, Sinigaglia, L, additional, and Tincani, A, additional

Published
2017
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30. Brief report: Successful pregnancies but a higher risk of preterm births in systemic sclerosis: An Italian multicentric study

Author

Taraborelli M, Ramoni V, Brucato A, Airò P, Bajocchi G, Bellisai F, Biasi D, Blagojevic J, Canti V, Caporali R, Caramaschi P, Chiarolanza I, Codullo V, Cozzi F, Cutolo M, De Santis M, De Vita S, Di Poi E, Doria A, Faggioli P, Favaro M, Ferraccioli G, Ferri C, Foti R, Gerosa A, Gerosa M, Giacuzzo S, GianiL, Giuggioli D, Imazio M, Iudici M, Iuliano A, Leonardi R, Limonta M, Lojacono A, Lubatti C, Matucci Cerinic M, Mazzone A, Meroni M, Meroni PL, Mosca M, Motta M, Muscarà M, Nava S, Padovan M, Pagani G, Paolazzi G, Peccatori S, Ravagnani V, Riccieri V, Rosato E, Rovere Querini P, Salsano F, Santaniello A, Scorza R, Tani C, Valesini G, Vanoli M, Vigone B, Zeni S, Tincani A, on behalf ofthe IMPRESS Investigators, CUOMO, Giovanna, VALENTINI, Gabriele, Taraborelli, M, Ramoni, V, Brucato, A, Airò, P, Bajocchi, G, Bellisai, F, Biasi, D, Blagojevic, J, Canti, V, Caporali, R, Caramaschi, P, Chiarolanza, I, Codullo, V, Cozzi, F, Cuomo, Giovanna, Cutolo, M, De Santis, M, De Vita, S, Di Poi, E, Doria, A, Faggioli, P, Favaro, M, Ferraccioli, G, Ferri, C, Foti, R, Gerosa, A, Gerosa, M, Giacuzzo, S, Gianil, Giuggioli, D, Imazio, M, Iudici, M, Iuliano, A, Leonardi, R, Limonta, M, Lojacono, A, Lubatti, C, Matucci Cerinic, M, Mazzone, A, Meroni, M, Meroni, Pl, Mosca, M, Motta, M, Muscarà, M, Nava, S, Padovan, M, Pagani, G, Paolazzi, G, Peccatori, S, Ravagnani, V, Riccieri, V, Rosato, E, Rovere Querini, P, Salsano, F, Santaniello, A, Scorza, R, Tani, C, Valentini, Gabriele, Valesini, G, Vanoli, M, Vigone, B, Zeni, S, Tincani, A, and on behalf ofthe IMPRESS, Investigators

Abstract

OBJECTIVE: To assess fetal and maternal outcomes in women with systemic sclerosis (SSc). METHODS: Prospectively collected data on 99 women with SSc from 25 Italian centers were analyzed retrospectively. Women with SSc were observed during 109 pregnancies (from 2000 to 2011), and outcomes were compared to those in the general obstetric population (total of 3,939 deliveries). The maternal age at conception was a mean ± SD 31.8 ± 5.3 years, and the median disease duration at conception was 60 months (range 2-193 months). RESULTS: SSc patients, compared to the general obstetric population, had a significantly increased frequency of preterm deliveries (25% versus 12%) and severe preterm deliveries (

Published
2012

32. SAT0196 Impress 2 (International Multicentric Prospective Study on Pregnancy in Systemic Sclerosis). Prospective, Case-Control Study of Pregnancy in Systemic Sclerosis

Author

Betelli, M., primary, Ramoni, V., additional, Meroni, M., additional, Allanore, Y., additional, Baresic, M., additional, Beneventi, F., additional, Caramaschi, P., additional, Cutolo, M., additional, Favaro, M., additional, Govoni, M., additional, Hachulla, E., additional, Limonta, M., additional, Matucci Cerinic, M., additional, Riccieri, V., additional, Rosato, E., additional, Salsano, F., additional, Scolack, M., additional, Smith, V., additional, Taraborelli, M., additional, Tincani, A., additional, Valentini, G., additional, Vonk, M., additional, and Brucato, A., additional

Published
2016
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34. Systemic vasculitis and pregnancy: A multicenter study on maternal and neonatal outcome of 65 prospectively followed pregnancies

Author

Fredi, M, Lazzaroni, M, Tani, C, Ramoni, V, Gerosa, M, Inverardi, F, Sfriso, P, Caramaschi, P, Andreoli, L, Sinico, R, Motta, M, Lojacono, A, Trespidi, L, Strigini, F, Brucato, A, Caporali, R, Doria, A, Guillevin, L, Meroni, P, Montecucco, C, Mosca, M, Tincani, A, Tincani, A., SINICO, RENATO ALBERTO, BRUCATO, ANTONIO LUCA, Fredi, M, Lazzaroni, M, Tani, C, Ramoni, V, Gerosa, M, Inverardi, F, Sfriso, P, Caramaschi, P, Andreoli, L, Sinico, R, Motta, M, Lojacono, A, Trespidi, L, Strigini, F, Brucato, A, Caporali, R, Doria, A, Guillevin, L, Meroni, P, Montecucco, C, Mosca, M, Tincani, A, Tincani, A., SINICO, RENATO ALBERTO, and BRUCATO, ANTONIO LUCA

Abstract

Objective: Systemic vasculitis (SV) are uncommon diseases that rarely affect women during their reproductive age; little data, mainly retrospective, is available on this topic. The aim of our study was to evaluate maternal/neonatal outcome and disease course before, during and after pregnancy. Methods: Sixty-five pregnancies in 50 women with SV were followed by a multispecialistic team in 8 institutions between 1995 and 2014. Clinical data on pregnancy, 1. year before and 1. year after delivery was retrospectively collected. The rate of pregnancy complications was compared to that of a General Obstetric Population (GOP) of 3939 women. Results: In 2 patients the diagnosis of SV was done during pregnancy; 59 out of the remaining 63 started when maternal disease was quiescent. We recorded 56 deliveries with 59 live births, 8 miscarriages and 1 fetal death. In SV, preterm, particularly early preterm (<. 34. weeks) deliveries and cesarean sections appeared significantly more frequent than in GOP (11.3% vs 5.0%, p=. 0.049 and 48.2% vs 31.0%, p=. 0.009).Vasculitis-related complications occurred in 23 pregnancies (35.4%), with 5 severe events (7.7%) including 3 cases of transient ischemic attack (TIA). Data about the post-partum period were available for 56 pregnancies: 12 flares (21.4%) occurred, with 1 severe event (1.8%). Conclusion: SV patients can have successful pregnancies (especially during a disease remission phase) despite an increased rate of preterm delivery. Severe flares were limited, but the occurrence of 3 TIA suggests that particular attention should be given to possible thrombotic complications in SV patients during pregnancy and puerperium.

Published
2015

35. Brief Report: Successful pregnancies but a higher riskof preterm births in patients with systemic sclerosis: An Italian multicenterstudy

Author

Taraborelli, M, Ramoni, V, Brucato, A, Airò, P, Bajocchi, G, Bellisai, F, Biasi, D, Blagojevic, J, Canti, V, Caporali, R, Caramaschi, P, Chiarolanza, I, Codullo, V, Cozzi, Franco, Cuomo, G, Cutolo, M, De Santis, M, De Vita, S, Di Poi, E, Doria, Andrea, Faggioli, P, Favaro, M, Ferraccioli, G, Ferri, C, Foti, R, Gerosa, A, Gerosa, M, Giacuzzo, S, Giani, L, Giuggioli, D, Imazio, M, Iudici, M, Iuliano, A, Leonardi, R, Limonta, M, Lojacono, A, Lubatti, C, Matucci Cerinic, M, Mazzone, A, Meroni, M, Meroni, Pl, Mosca, M, Motta, M, Muscarà, M, Nava, S, Padovan, M, Pagani, G, Paolazzi, G, Peccatori, S, Ravagnani, V, Riccieri, V, Rosato, E, Rovere Querini, P, Salsano, F, Santaniello, A, Scorza, R, Tani, C, Valentini, G, Valesini, G, Vanoli, M, Vigone, B, Zeni, S, and Tincani, A.

Published
2012

44. Systemic Vasculitis and Pregnancy: A Multicenter Study on Maternal and Neonatal Outcome of 66 Prospectively Followed Pregnancies

Author

Lazzaroni, M, Fredi, M, Andreoli, L, Brucato, A, Caporali, R, Caramaschi, P, Doria, A, Gerosa, M, Guillevin, L, Inverardi, F, Lojacono, A, Meroni, P, Montecucco, C, Mosca, M, Motta, M, Ramoni, V, Sfriso, P, Sinico, R, Strigini, F, Tani, C, Tincani, A, BRUCATO, ANTONIO LUCA, SINICO, RENATO ALBERTO, Tincani, A., Lazzaroni, M, Fredi, M, Andreoli, L, Brucato, A, Caporali, R, Caramaschi, P, Doria, A, Gerosa, M, Guillevin, L, Inverardi, F, Lojacono, A, Meroni, P, Montecucco, C, Mosca, M, Motta, M, Ramoni, V, Sfriso, P, Sinico, R, Strigini, F, Tani, C, Tincani, A, BRUCATO, ANTONIO LUCA, SINICO, RENATO ALBERTO, and Tincani, A.

Published
2014

45. Treatment strategies and pregnancy outcomes in antiphospholipid syndrome patients with thrombosis and triple antiphospholipid positivity. A European multicentre retrospective study.

Author

Ruffatti, A, Salvan, E, Del Ross, T, Gerosa, M, Andreoli, L, Maina, A, Alijotas-Reig, J, De Carolis, Sara, Mekinian, A, Bertero, Mt, Canti, V, Brucato, A, Bremme, K, Ramoni, V, Mosca, M, Di Poi, E, Caramaschi, P, Galeazzi, M, Tincani, A, Trespidi, L., De Carolis S (ORCID:0000-0002-5160-7609), Ruffatti, A, Salvan, E, Del Ross, T, Gerosa, M, Andreoli, L, Maina, A, Alijotas-Reig, J, De Carolis, Sara, Mekinian, A, Bertero, Mt, Canti, V, Brucato, A, Bremme, K, Ramoni, V, Mosca, M, Di Poi, E, Caramaschi, P, Galeazzi, M, Tincani, A, Trespidi, L., and De Carolis S (ORCID:0000-0002-5160-7609)

Abstract

Previous thrombosis, diagnosis of systemic lupus erythematosus (SLE) and triple antiphospholipid (aPL) antibody positivity have recently been found to be independent factors associated to pregnancy failure during conventional therapy in women with antiphospholipid syndrome (APS). This study aimed to assess the effect of various treatment strategies on pregnancy outcomes in women with APS and the risk factors for pregnancy failure. One hundred ninety-six pregnancies of 156 patients diagnosed with APS were analysed: 118 (60.2%) of these had previous thrombosis, 81 (41.3%) were diagnosed with SLE, and 107 (54.6%) had triple aPL positivity. One hundred seventy-five (89.3%) were treated with conventional therapies (low-dose aspirin [LDA] or prophylactic doses of heparin + LDA or therapeutic doses of heparin + LDA), while 21 (10.7%) were prescribed other treatments in addition to conventional therapy. The pregnancies were classified into seven risk profiles depending on the patients' risk factors - thrombosis, SLE, and triple aPL positivity - and their single, double or triple combinations. It was possible to find significant difference in outcomes correlated to treatments only in the thrombosis plus triple aPL positivity subset, and logistic regression analysis showed that additional treatments were the only independent factor associated to a favourable pregnancy outcome (odds ratio=9.7, 95% confidence interval=1.1-88.9, p-value<0.05). On the basis of this retrospective study, we found that APS pregnant patients with thrombosis and triple aPL positivity treated with additional therapy had a significant higher live-birth rate with respect to those receiving conventional therapy alone.

Published
2014

50. OP0230 Systemic Vasculitis and Pregnancy: A Multicenter Study on Maternal and Neonatal Outcome of 66 Prospectively Followed Pregnancies

Author

Lazzaroni, M.G., primary, Fredi, M., additional, Andreoli, L., additional, Brucato, A., additional, Caporali, R., additional, Caramaschi, P., additional, Doria, A., additional, Gerosa, M., additional, Guillevin, L., additional, Inverardi, F., additional, Lojacono, A., additional, Meroni, P.L., additional, Montecucco, C., additional, Mosca, M., additional, Motta, M., additional, Ramoni, V., additional, Sfriso, P., additional, Sinico, R.A., additional, Strigini, F., additional, Tani, C., additional, and Tincani, A., additional

Published
2014
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