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345 results on '"Ramli, Norlisah"'

12. Missense Mutation of Brain Derived Neurotrophic Factor (BDNF) Alters Neurocognitive Performance in Patients with Mild Traumatic Brain Injury: A Longitudinal Study.

Author

Narayanan, Vairavan, Veeramuthu, Vigneswaran, Ahmad-Annuar, Azlina, Ramli, Norlisah, Waran, Vicknes, Chinna, Karuthan, Bondi, Mark William, Delano-Wood, Lisa, and Ganesan, Dharmendra

Subjects
Humans, Brain Concussion, Brain-Derived Neurotrophic Factor, Longitudinal Studies, Cognition, Neuropsychological Tests, Demography, Mutation, Missense, Polymorphism, Single Nucleotide, Alleles, Adult, Female, Male, Mutation, Missense, Polymorphism, Single Nucleotide, General Science & Technology
Abstract

The predictability of neurocognitive outcomes in patients with traumatic brain injury is not straightforward. The extent and nature of recovery in patients with mild traumatic brain injury (mTBI) are usually heterogeneous and not substantially explained by the commonly known demographic and injury-related prognostic factors despite having sustained similar injuries or injury severity. Hence, this study evaluated the effects and association of the Brain Derived Neurotrophic Factor (BDNF) missense mutations in relation to neurocognitive performance among patients with mTBI. 48 patients with mTBI were prospectively recruited and MRI scans of the brain were performed within an average 10.1 (SD 4.2) hours post trauma with assessment of their neuropsychological performance post full Glasgow Coma Scale (GCS) recovery. Neurocognitive assessments were repeated again at 6 months follow-up. The paired t-test, Cohen's d effect size and repeated measure ANOVA were performed to delineate statistically significant differences between the groups [wildtype G allele (Val homozygotes) vs. minor A allele (Met carriers)] and their neuropsychological performance across the time point (T1 = baseline/ admission vs. T2 = 6th month follow-up). Minor A allele carriers in this study generally performed more poorly on neuropsychological testing in comparison wildtype G allele group at both time points. Significant mean differences were observed among the wildtype group in the domains of memory (M = -11.44, SD = 10.0, p = .01, d = 1.22), executive function (M = -11.56, SD = 11.7, p = .02, d = 1.05) and overall performance (M = -6.89 SD = 5.3, p = .00, d = 1.39), while the minor A allele carriers showed significant mean differences in the domains of attention (M = -11.0, SD = 13.1, p = .00, d = .86) and overall cognitive performance (M = -5.25, SD = 8.1, p = .01, d = .66).The minor A allele carriers in comparison to the wildtype G allele group, showed considerably lower scores at admission and remained impaired in most domains across the timepoints, although delayed signs of recovery were noted to be significant in the domains attention and overall cognition. In conclusion, the current study has demonstrated the role of the BDNF rs6265 Val66Met polymorphism in influencing specific neurocognitive outcomes in patients with mTBI. Findings were more detrimentally profound among Met allele carriers.

Published
2016

15. Diffusion Tensor Imaging Parameters in Mild Traumatic Brain Injury and Its Correlation with Early Neuropsychological Impairment: A Longitudinal Study.

Author

Veeramuthu, Vigneswaran, Narayanan, Vairavan, Kuo, Tan, Delano-Wood, Lisa, Chinna, Karuthan, Bondi, Mark, Waran, Vicknes, Ganesan, Dharmendra, and Ramli, Norlisah

Subjects
DTI, ROI, TBSS, imaging biomarker, mTBI, neuropsychology, Adolescent, Adult, Biomarkers, Brain, Brain Injuries, Diffusion Tensor Imaging, Female, Glasgow Coma Scale, Humans, Image Processing, Computer-Assisted, Longitudinal Studies, Male, Mental Disorders, Middle Aged, Nervous System Diseases, Neuropsychological Tests, Prognosis, Prospective Studies, Recovery of Function, Treatment Outcome, White Matter, Young Adult
Abstract

We explored the prognostic value of diffusion tensor imaging (DTI) parameters of selected white matter (WM) tracts in predicting neuropsychological outcome, both at baseline and 6 months later, among well-characterized patients diagnosed with mild traumatic brain injury (mTBI). Sixty-one patients with mTBI (mean age=27.08; standard deviation [SD], 8.55) underwent scanning at an average of 10 h (SD, 4.26) post-trauma along with assessment of their neuropsychological performance at an average of 4.35 h (SD, 7.08) upon full Glasgow Coma Scale recovery. Results were then compared to 19 healthy control participants (mean age=29.05; SD, 5.84), both in the acute stage and 6 months post-trauma. DTI and neuropsychological measures between acute and chronic phases were compared, and significant differences emerged. Specifically, chronic-phase fractional anisotropy and radial diffusivity values showed significant group differences in the corona radiata, anterior limb of internal capsule, cingulum, superior longitudinal fasciculus, optic radiation, and genu of corpus callosum. Findings also demonstrated associations between DTI indices and neuropsychological outcome across two time points. Our results provide new evidence for the use of DTI as an imaging biomarker and indicator of WM damage occurring in the context of mTBI, and they underscore the dynamic nature of brain injury and possible biological basis of chronic neurocognitive alterations.

Published
2015

22. Expanding the DARS phenotype: Late-adult onset myelopathy and leukoencephalopathy

Author

Tan, Ai Huey, primary, Ng, Adeline Su Lyn, additional, Ramli, Norlisah Mohd, additional, Lim, Weng Khong, additional, Cheah, Peng Loon, additional, Teo, Jing Xian, additional, Kuan, Jyn Ling, additional, Tan, Yi Jayne, additional, Lim, Jia Lun, additional, Chew, Elaine Guo Yan, additional, Foo, Jia Nee, additional, Goh, Khean Jin, additional, Tan, Eng-King, additional, and Lim, Shen-Yang, additional

Published
2023
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26. Neuroimaging in dementia syndromes

Author

Rahmat, Kartini, primary, Haris Phuah, Affendi, additional, Ramli, Norlisah, additional, Muhammad Gowdh, Nadia Fareeda, additional, Chan, Wai Yee, additional, and Tan, Maw Pin, additional

Published
2022
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37. Preliminary study of longitudinal changes in the pituitary and brain of children on growth hormone therapy

Author

Low, Lee Shien, Wong, Jeannie Hsiu Ding, Tan, Li Kuo, Chan, Wai Yee, Jalaludin, Muhammad Yazid, Anuar Zaini, Azriyanti, and Ramli, Norlisah

Abstract

•IGHD children have smaller pituitary gland, hippocampus and amygdalas.•MRI provides an objective assessment of rhGH therapy response.•MRI assessment could optimize the diagnostic protocols for a short stature child.

Published
2023
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38. Spectrum of imaging findings of papillary breast disease

Author

Fadzli, Farhana, Rahmat, Kartini, Ramli, Marlina Tanty, Rozalli, Faizatul Izza, Hooi, Teoh Kean, Fadzli, Ahmad Nazran, Hoong, See Mee, Ramli, Norlisah Mohd, and Taib, Nur Aishah Mohd

Subjects
Adult, Aged, 80 and over, mammography, Biopsy, Observational Study, Breast Neoplasms, ultrasonography, Middle Aged, Diagnosis, Differential, papilloma, Breast Diseases, Young Adult, Cross-Sectional Studies, breast neoplasms, Nipple Discharge, Humans, Female, Breast, Research Article, Aged, Mammography, Retrospective Studies
Abstract

To evaluate the clinical and imaging findings of papillary breast neoplasm and review the pathologic correlation at a tertiary center. Retrospective study of patients diagnosed with benign and malignant papillary lesions between 2008 to 2018. 147 patients were identified with histology diagnosis of papillary lesions. The clinical, imaging, and pathological characteristics were reviewed. Patient cohort included 147 women diagnosed with papillary lesions (mean age at diagnosis 53.8 years) and were divided into 3 histology groups (benign, atypical, and malignant). Common clinical presentations were breast lump (n = 60) and nipple discharge (n = 29), 48 patients were asymptomatic. Only 37 were detected as a mass lesion on mammogram. The presence of mass lesion on mammogram was the most common feature in all 3 papillary lesion groups, and with the presence of asymmetric density, were the 2 mammographic features significantly associated (P

Published
2021

42. Automatic COVID-19 Detection Using Exemplar Hybrid Deep Features with X-ray Images

Author

Barua, Prabal Datta, primary, Muhammad Gowdh, Nadia Fareeda, additional, Rahmat, Kartini, additional, Ramli, Norlisah, additional, Ng, Wei Lin, additional, Chan, Wai Yee, additional, Kuluozturk, Mutlu, additional, Dogan, Sengul, additional, Baygin, Mehmet, additional, Yaman, Orhan, additional, Tuncer, Turker, additional, Wen, Tao, additional, Cheong, Kang Hao, additional, and Acharya, U. Rajendra, additional

Published
2021
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48. Outbreak of human infection with Sarcocystis nesbitti, Malaysia, 2012

Author

AbuBakar, Sazaly, Teoh, Boon-Teong, Sam, Sing-Sin, Chang, Li-Yen, Johari, Jefree, Hooi, Poh-Sim, Lakhbeer-Singh, Harvinder-Kaur, Italiano, Claire M., Omar, Sharifah F. Syed, Wong, Kum-Thong, Ramli, Norlisah, and Tan, Chong-Tin

Subjects
Parasitic diseases -- Diagnosis -- Health aspects, Infection -- Diagnosis -- Health aspects, RNA -- Health aspects, Health
Abstract

Sarcocystis spp. infections are emerging parasitic infections among travelers to potentially disease-endemic areas of Southeast Asia. More than 100 travelers acquired an acute, muscular, Sarcocystis spp. infection-like illness while traveling [...]

Published
2013

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