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Perioperative fluid management remains a challenging aspect of paediatric liver transplantation (LT) because of the risk of postoperative complications and haemodynamic instability. Limited research has specifically investigated the impact of fluid management and transfusion on mortality and morbidity in pediatric LT patients. This systematic review summarizes the evidence regarding perioperative fluid management and its clinical outcomes in paediatric LT patients. All primary studies published in English evaluating perioperative fluid management in paediatric LT patients were eligible. PubMed, EBSCOHost, Embase, Proquest, and Google Scholar databases were searched from inception to December 19, 2023. Risks of bias were assessed using the Joanna-Briggs Institute checklist. The results were synthesized narratively. Five retrospective cohort studies of good-excellent quality were included in this review. Two studies evaluated intraoperative fluid administration, one study compared postoperative fluid balance (FB) with outcomes, and two studies compared massive versus non-massive transfusion. A higher mortality rate was associated with intravenous lactated ringer's (LR) than with normal saline, but not with massive transfusion (MT). Longer hospital stays were correlated with MT, >20% positive FB in the first 72 hours, and greater total intraoperative blood product administration. Higher intraoperative fluid administration was associated with a greater thrombotic risk. Additionally, intraoperative MT and lR infusion were associated with an increased risk of 30-day graft loss and graft dysfunction, respectively. Fluid management may impact the outcomes of paediatric LT recipients. These findings underscore the need for more studies to explore the best fluid management and evaluation strategies for children undergoing LT. [ABSTRACT FROM AUTHOR]

Background: Neonates with congenital diaphragmatic hernia (CDH) present with respiratory distress and circulatory insufficiency, requiring immediate intubation and mechanical ventilation. Studies in the literature present contradictory results regarding the optimal ventilation mode for neonates with congenital diaphragmatic hernia. We present a systematic review of the selected literature regarding high-frequency oscillatory ventilation (HFOV) compared to conventional mechanical ventilation (CMV) in congenital diaphragmatic hernia. Methodology: PubMed, SCOPUS, EBSCOhost, and ProQuest databases were used to identify literature regarding HFOV compared to CMV in a CDH. The methodological quality of the included studies was assessed using the Newcastle-Ottawa Scale (NOS) for cohort studies and the Joanna Briggs Institute critical appraisal tool for randomized clinical trials. The search was conducted between the 23rd of October 2020 to November 2020. Articles that were included were published within the last twenty years (2000-2020). The following search and Boolean terms were used for the search of relevant articles: "Congenital Diaphragmatic Hernia" AND "high frequency" AND neonate AND "conventional mechanical ventilation". Results: Four studies were identified and considered eligible for the study. One study was a randomized clinical trial, and the other three cohort studies. Patients in the high-frequency oscillatory (HFO) group presented with a higher length of ventilation and hospital stay. There was a lack of evidence regarding any significant difference in the mortality rate. Conclusion: We cannot make an evidence-based recommendation regarding the superiority of either CMV or HFOV as the optimal ventilation method in neonates with CDH. However, almost all studies observed a lengthened period of ventilation and time required before surgical repair in the HFOV group. [ABSTRACT FROM AUTHOR]

Background: Mortality predictors are often used for analyzing disease progression as a guide for disease management strategy. The sequential organ failure assessment (SOFA) score is a predictor tool used to analyze organ dysfunction in critically ill patients. This study aimed to validate the SOFA score in predicting 28-day mortality in critically ill Coronavirus disease 2019 (COVID-19) patients. Methods: Subjects included in this study were critically ill, confirmed COVID-19 cases admitted to the intensive care unit (ICU) between March and August 2020. Demographic data, clinical characteristics, and laboratory findings within the first 24 hours of ICU admission were obtained from medical records to compute the SOFA score. The 28-day outcome was recorded as alive or deceased. Validity was analyzed using the area under the curve (AUC), Hosmer-Lemeshow goodness of fit, and bivariate logistic regression. The optimal cut-off point was determined statistically. Result: From the total of 88 subjects in this study, the mortality rate was 39.8%. AUC was 0.971 (confidence interval [CI] 95% 0.943-0.999), and the goodness of fit test by using Hosmer-Lemeshow showed p=0.782. An optimal cut-off point of SOFA score was 6, with a sensitivity of 87% and specificity of 90%. Discussion: SOFA score demonstrated very strong discrimination and good calibration in predicting 28-day mortality on the critical case of COVID-19. Conclusion: The SOFA score is valid for predicting 28-day mortality in the critical case of COVID-19. [ABSTRACT FROM AUTHOR]

Sevoflurane has been shown to increase the incidence of emergence delirium in children; however, the mechanism remains unclear. Sevoflurane increases cytoplasmic calcium concentration which in turn may play a role in emergence delirium. This study aimed to investigate the level of intracellular calcium in rats experiencing hyperexcitatory behavior after exposure to sevoflurane, as well as the role of magnesium in preventing this phenomenon. After ethical approval, 2-5-week-old Sprague-Dawley rats (n = 34) were insufflated with sevoflurane in a modified anesthesia chamber. One group received magnesium sulphate intraperitoneally. After termination of sevoflurane exposure, the occurrence of hyperexcitation was observed. Brain tissue samples from the rats were studied for intracellular calcium levels under a two-channel laser scanning confocal microscope and were quantitatively calculated using ratiometric calculation. The presence of inflammation or oxidative stress reaction was assessed using nuclear factor κB and malondialdehyde. The incidence of hyperexcitatory behavior post sevoflurane exposure was 9 in 16 rats in the observation group and none in the magnesium group. Tests for inflammation and oxidative stress were within normal limits in both groups. The rats showing hyperexcitation had a higher level of cytosol calcium concentration compared to the other groups. To conclude, the calcium concentration of neocortical neurons in Sprague-Dawley rats with hyperexcitatory behavior is increased after exposure to sevoflurane. Administration of magnesium sulphate can prevent the occurrence of hyperexcitation in experimental animals., (Copyright © 2024 Copyright: © 2024 Medical Gas Research.)

Objective: Emergence delirium (ED) is a condition that can occur when a child recovers from anaesthesia uncomfortably. ED can potentially injure children and indirectly discomforts parents. Various interventions were carried out to reduce ED, but there is no specific standard that has been established to prevent ED. Dexmedetomidine and midazolam are said to be effective in reducing ED. This study aims to determine the effectiveness of intranasal dexmedetomidine premedication compared to intranasal midazolam to prevent ED in children undergoing eye surgery., Methods: This study was a double-blinded randomised clinical trial. Paediatric patients aged 1-12 years with physical status ASA 1 and 2 who underwent eye surgery under general anaesthesia using sevoflurane inhalation were included in the study. There were 64 children obtained by consecutive sampling who underwent eye surgery in our institution between February and May 2019. The subjects were then randomised into the dexmedetomidine group and the midazolam group. Effectiveness was assessed from ED events, recovery time and post-premedication desaturation events. Data analysis was performed using Chi-square test and Mann-Whitney test., Results: ED incidence in the dexmedetomidine group was 11.18% compared to 28.12% in the midazolam group (P ¼ .109). The recovery time was found to be at a median of 6 minutes for both groups, and no desaturation was found in either group., Conclusion: There is statistically no significant difference between the effectiveness of intranasal dexmedetomidine and midazolam premedication 30 minutes before induction to prevent ED occurrence in children undergoing eye surgery.

Background and Aims: Emergence agitation (EA) is a common transient behavioral disturbance after inhalational anesthesia and may cause harm to the patient. This study evaluated the efficacy of 0.5 mg/kg of propofol administered at the end of anesthesia to reduce the incidence of EA in children undergoing general inhalational anesthesia., Material and Methods: This double-blind randomized clinical trial was done in children aged 1-5 years undergoing general anesthesia with sevoflurane. One hundred and eight subjects were included using consecutive sampling method and randomized into two equal groups. Propofol in the dose of 0.5 mg/kg was administered at the end of anesthesia to children in the propofol group, while those in the control group did not receive any intervention at the end of anesthesia. Incidence of EA, transfer time, postoperative hypotension, desaturation, and nausea-vomiting were observed. Aono and Pediatric Anesthesia Emergence Delirium scale were used to assess EA., Results: Incidence of EA was 25.9% in the propofol group compared to 51.9% in the control group (RR = 0.500; 95% CI 0.298-0.840; P = 0.006). Mean transfer time in propofol group was longer (9.5 ± 3.9 min) than control group (7.8 ± 3.6 min) (mean difference 1.71 min; 95% CI 0.28-3.14; P = 0.020). Hypotension was found in one patient (1.9%) in propofol group, while in control group there was none. Nausea-vomiting was found in five patients (9.3%) in propofol group and eight patients (14.8%) in control. There was no desaturation in both the groups., Conclusion: Administration of 0.5 mg/kg of propofol at the end of anesthesia effectively reduces the incidence of EA in children undergoing general inhalational anesthesia with sevoflurane., Competing Interests: There are no conflicts of interest., (Copyright: © 2020 Journal of Anaesthesiology Clinical Pharmacology.)