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4. Outcome of patients supported with the HeartMate 3 after extracorporeal life support: On behalf of the Durable Mechanical Circulatory Support After Extracorporeal Life Support Study Group

Author

Saeed, Diyar, Stark, Christoffer, Otto, Wolfgang, Loforte, Antonio, Zimpfer, Daniel, Bernhardt, Alexander M., Potapov, Evgenij, Morshius, Michiel, Schibilsky, David, Albert, Alexander, Raweh, Ayman, Riebandt, Julia, Pappalardo, Federico, Attisani, Matteo, Rinaldi, Mauro, Haneya, Assad, Huenges, Katharina, Ramjankhan, Faiz, Jorde, Ulrich P., Lewin, Daniel, Jawad, Khalil, Aubin, Hug, Ayala, Rafael, Reichenspurner, Hermann, Lichtenberg, Artur, Borger, Michael, and Gummert, Jan

Published
2024
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8. Case Report: Optimal utilization of marginal lung allografts by considering donor-recipient PGD risk compatibility and by mitigating allograft and recipient inflammatory risk.

Author

Braithwaite, Sue A., Jennekens, Jitte, Berg, Elize M., de Heer, Linda M., Ramjankhan, Faiz, de Jong, Michel, Charlier, Jean Luc, Dessing, Thomas C., Veltkamp, Marcel, Scheren, Amy S., Ruigrok, Dieuwertje, Schönwetter, Rob H. J., Buhre, Wolfgang F. F. A., and der Kaaij, Niels P. van

Published
2024
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9. Outcome after left ventricular assist device exchange.

Author

Niamat, Jaiel, Ramjankhan, Faiz, Kaaij, Niels Van Der, Gianoli, Monica, Laake, Linda W Van, and Mokhles, Mostafa M

Subjects
*LOGISTIC regression analysis, *RESPIRATORY insufficiency, *HEART transplantation, *HEART failure, *LUNG infections, *HEART assist devices
Abstract

OBJECTIVES Left ventricular assist device (LVAD) therapy has evolved from a short-term bridge-to-transplant strategy into a long-term and often chronic therapy due to long waiting times for heart transplantation and application as destination therapy. Consequently, patients are at risk of developing complications necessitating LVAD exchange. The aim of this study is to assess patient outcomes after LVAD exchange. METHODS Patients who underwent LVAD exchange between January 2010 and December 2022 were included. Logistic and cox regression analyses were used to identify potential risk factors for short and long-term adverse events, respectively. Survival after exchange was assessed using Kaplan–Meier estimates. RESULTS Sixty-one patients underwent a total of 80 LVAD exchanges. Most frequently observed short-term complications were pulmonary infections (16.3%) and right heart failure (16.3%). Exit-site infections (34.7%) and device malfunctions (25.3%) were the most often observed long-term complications. HeartWare ventricular assist device as index device was associated with a higher risk of right heart failure [hazard ratio 6.42, 95% confidence interval (CI) 1.80–22.90] and respiratory failure (hazard ratio 7.81, 95% CI 1.95–31.23) compared to HeartMate II and HeartMate 3. Survival was 83% (95% CI 75.5–95.3%) at 1 year and 67% (95% CI 53.9–84.7%) at 6 years after exchange. After 5 years, 25.0% was transplanted, 23.8% had undergone a re-exchange and 32.5% was alive without new intervention. CONCLUSIONS Although LVAD exchange can be performed with a relatively low mortality, other post-operative adverse events are common. Patients with the HeartWare ventricular assist device as index device may be at higher risk of developing right heart failure and respiratory failure after exchange. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Stroke Complications in Patients Requiring Durable Mechanical Circulatory Support Systems After Extracorporeal Life Support

Author

Saeed, Diyar, Loforte, Antonio, Morshuis, Michiel, Schibilsky, David, Zimpfer, Daniel, Riebandt, Julia, Pappalardo, Federico, Attisani, Matteo, Rinaldi, Mauro, Haneya, Assad, Ramjankhan, Faiz, Donker, Dirk W., Jorde, Ulrich P., Pacini, Davide, Otto, Wolfgang, Stein, Julia, Lewin, Daniel, Jawad, Khalil, Wieloch, Radi, Ayala, Rafael, Cremer, Jochen, Borger, Michael A., Lichtenberg, Artur, Gummert, Jan, and Potapov, Evgenij

Published
2023
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12. Soluble Suppression of Tumorigenicity-2 Predicts Mortality and Right Heart Failure in Patients With a Left Ventricular Assist Device

Author

Cardiologie, Onderzoek Precision medicine, CTC, Circulatory Health, Team Medisch, MCS-team, CDL Cluster 24/7 centraal laboratorium, Other research (not in main researchprogram), Regenerative Medicine and Stem Cells, Numan, Lieke, Aarts, Emmeke, Ramjankhan, Faiz, Oerlemans, Marish I.F., van der Meer, Manon G., de Jonge, Nicolaas, Oppelaar, Anne Marie, Kemperman, Hans, Asselbergs, Folkert W., Van Laake, Linda W., Cardiologie, Onderzoek Precision medicine, CTC, Circulatory Health, Team Medisch, MCS-team, CDL Cluster 24/7 centraal laboratorium, Other research (not in main researchprogram), Regenerative Medicine and Stem Cells, Numan, Lieke, Aarts, Emmeke, Ramjankhan, Faiz, Oerlemans, Marish I.F., van der Meer, Manon G., de Jonge, Nicolaas, Oppelaar, Anne Marie, Kemperman, Hans, Asselbergs, Folkert W., and Van Laake, Linda W.

Published
2024

13. FLAVOUR Study: FLow profiles And postoperative VasOplegia after continUous-flow left ventriculaR assist device implantation

Author

AIOS Anesthesiologie, Cardiologie, Onderzoek Precision medicine, CTC, Circulatory Health, Team Medisch, Regenerative Medicine and Stem Cells, Medische Staf Spoedeisende Hulp, Kersten, Bas J., Numan, Lieke, van der Schoot, Marnix M., de Jong, Michel, Ramjankhan, Faiz, Aarts, Emmeke, Oerlemans, Marish I.F.J., van Laake, Linda W., de Waal, Eric E.C., AIOS Anesthesiologie, Cardiologie, Onderzoek Precision medicine, CTC, Circulatory Health, Team Medisch, Regenerative Medicine and Stem Cells, Medische Staf Spoedeisende Hulp, Kersten, Bas J., Numan, Lieke, van der Schoot, Marnix M., de Jong, Michel, Ramjankhan, Faiz, Aarts, Emmeke, Oerlemans, Marish I.F.J., van Laake, Linda W., and de Waal, Eric E.C.

Published
2024

14. Outcome of patients supported with the HeartMate 3 after extracorporeal life support: On behalf of the Durable Mechanical Circulatory Support After Extracorporeal Life Support Study Group

Author

CTC, Circulatory Health, Saeed, Diyar, Stark, Christoffer, Otto, Wolfgang, Loforte, Antonio, Zimpfer, Daniel, Bernhardt, Alexander M., Potapov, Evgenij, Morshius, Michiel, Schibilsky, David, Albert, Alexander, Raweh, Ayman, Riebandt, Julia, Pappalardo, Federico, Attisani, Matteo, Rinaldi, Mauro, Haneya, Assad, Huenges, Katharina, Ramjankhan, Faiz, Jorde, Ulrich P., Lewin, Daniel, Jawad, Khalil, Aubin, Hug, Ayala, Rafael, Reichenspurner, Hermann, Lichtenberg, Artur, Borger, Michael, Gummert, Jan, CTC, Circulatory Health, Saeed, Diyar, Stark, Christoffer, Otto, Wolfgang, Loforte, Antonio, Zimpfer, Daniel, Bernhardt, Alexander M., Potapov, Evgenij, Morshius, Michiel, Schibilsky, David, Albert, Alexander, Raweh, Ayman, Riebandt, Julia, Pappalardo, Federico, Attisani, Matteo, Rinaldi, Mauro, Haneya, Assad, Huenges, Katharina, Ramjankhan, Faiz, Jorde, Ulrich P., Lewin, Daniel, Jawad, Khalil, Aubin, Hug, Ayala, Rafael, Reichenspurner, Hermann, Lichtenberg, Artur, Borger, Michael, and Gummert, Jan

Published
2024

15. ECPELLA as a bridge-to-decision in refractory cardiogenic shock:a single-centre experience

Author

Balder, Jan Willem, Szymanski, Mariusz K., van Laake, Linda W., van der Harst, Pim, Meuwese, Christiaan L., Ramjankhan, Faiz Z., van der Meer, Manon G., Hermens, Jeannine A.J.M., Voskuil, Michiel, de Waal, Eric E.C., Donker, Dirk W., Oerlemans, Marish I.F.J., Kraaijeveld, Adriaan O., Balder, Jan Willem, Szymanski, Mariusz K., van Laake, Linda W., van der Harst, Pim, Meuwese, Christiaan L., Ramjankhan, Faiz Z., van der Meer, Manon G., Hermens, Jeannine A.J.M., Voskuil, Michiel, de Waal, Eric E.C., Donker, Dirk W., Oerlemans, Marish I.F.J., and Kraaijeveld, Adriaan O.

Abstract

Background: In refractory cardiogenic shock, temporary mechanical support (tMCS) may be crucial for maintaining tissue perfusion and oxygen delivery. tMCS can serve as a bridge-to-decision to assess eligibility for left ventricular assist device (LVAD) implantation or heart transplantation, or as a bridge-to-recovery. ECPELLA is a novel tMCS configuration combining venoarterial extracorporeal membrane oxygenation with Impella. The present study presents the clinical parameters, outcomes, and complications of patients supported with ECPELLA. Methods: All patients supported with ECPELLA at University Medical Centre Utrecht between December 2020 and August 2023 were included. The primary outcome was 30-day mortality, and secondary outcomes were LVAD implantation/heart transplantation and safety outcomes. Results: Twenty patients with an average age of 51 years, and of whom 70% were males, were included. Causes of cardiogenic shock were acute heart failure (due to acute coronary syndrome, myocarditis, or after cardiac surgery) or chronic heart failure, respectively 70 and 30% of cases. The median duration of ECPELLA support was 164 h (interquartile range 98–210). In 50% of cases, a permanent LVAD was implanted. Cardiac recovery within 30 days was seen in 30% of cases and 30-day mortality rate was 20%. ECPELLA support was associated with major bleeding (40%), haemolysis (25%), vascular complications (30%), kidney failure requiring replacement therapy (50%), and Impella failure requiring extraction (15%). Conclusion: ECPELLA can be successfully used as a bridge to LVAD implantation or as a bridge-to-recovery in patients with refractory cardiogenic shock. Despite a significant number of complications, 30-day mortality was lower than observed in previous cohorts.

Published
2024

16. The European Registry for Patients with Mechanical Circulatory Support (EUROMACS): fourth Paediatric EUROMACS (Paedi-EUROMACS) report

Author

CTC, Circulatory Health, Rohde, Sofie, van Puyvelde, Joeri, Veen, Kevin M., Schweiger, Martin, Biermann, Daniel, Amodeo, Antonio, Martens, Thomas, Damman, Kevin, Gollmann-Tepeköylü, Can, Hulman, Michael, Iacovoni, Attilio, Krämer, Ulrike S., Loforte, Antonio, Pace Napoleone, Carlo, Nemec, Petr, Netuka, Ivan, Özbaran, Mustafa, Polo, Luz, Pya, Yuriy, Ramjankhan, Faiz, Sandica, Eugen, Sliwka, Joanna, Stiller, Brigitte, Kadner, Alexander, Franceschini, Alessio, Thiruchelvam, Timothy, Zimpfer, Daniel, Berger, Felix, Davies, Ben, Dashkevich, Alexey, Stark, Christoffer, Meyns, Bart, de By, Theo M.M.H., Miera, Oliver, CTC, Circulatory Health, Rohde, Sofie, van Puyvelde, Joeri, Veen, Kevin M., Schweiger, Martin, Biermann, Daniel, Amodeo, Antonio, Martens, Thomas, Damman, Kevin, Gollmann-Tepeköylü, Can, Hulman, Michael, Iacovoni, Attilio, Krämer, Ulrike S., Loforte, Antonio, Pace Napoleone, Carlo, Nemec, Petr, Netuka, Ivan, Özbaran, Mustafa, Polo, Luz, Pya, Yuriy, Ramjankhan, Faiz, Sandica, Eugen, Sliwka, Joanna, Stiller, Brigitte, Kadner, Alexander, Franceschini, Alessio, Thiruchelvam, Timothy, Zimpfer, Daniel, Berger, Felix, Davies, Ben, Dashkevich, Alexey, Stark, Christoffer, Meyns, Bart, de By, Theo M.M.H., and Miera, Oliver

Published
2024

17. Healthcare consumption of patients with left ventricular assist device: real-world data

Author

Arts Assistenten Cardiologie, Verpleegkundig Specialisten Cardiologie, Team Medisch, CTC, Circulatory Health, Gezonde Vaten, Regenerative Medicine and Stem Cells, Bosch, Lena, Zwetsloot, Peter-Paul M, Brons, Maaike, van Hout, Gerardus P J, van der Meer, Manon G, Szymanski, Mariusz K, Troost-Oppelaar, Anne-Marie, Ramjankhan, Faiz Z, van der Harst, Pim, Gianoli, Monica, Oerlemans, Marish I F J, van Laake, Linda W, Arts Assistenten Cardiologie, Verpleegkundig Specialisten Cardiologie, Team Medisch, CTC, Circulatory Health, Gezonde Vaten, Regenerative Medicine and Stem Cells, Bosch, Lena, Zwetsloot, Peter-Paul M, Brons, Maaike, van Hout, Gerardus P J, van der Meer, Manon G, Szymanski, Mariusz K, Troost-Oppelaar, Anne-Marie, Ramjankhan, Faiz Z, van der Harst, Pim, Gianoli, Monica, Oerlemans, Marish I F J, and van Laake, Linda W

Published
2024

18. ECPELLA as a bridge-to-decision in refractory cardiogenic shock: a single-centre experience

Author

Cardiologie, Team Medisch, Circulatory Health, Regenerative Medicine and Stem Cells, Gezonde Vaten, CTC, Medische Staf Intensive Care, Medische Staf Spoedeisende Hulp, Medische staf Anesthesiologie, Other research (not in main researchprogram), Balder, Jan Willem, Szymanski, Mariusz K., van Laake, Linda W., van der Harst, Pim, Meuwese, Christiaan L., Ramjankhan, Faiz Z., van der Meer, Manon G., Hermens, Jeannine A.J.M., Voskuil, Michiel, de Waal, Eric E.C., Donker, Dirk W., Oerlemans, Marish I.F.J., Kraaijeveld, Adriaan O., Cardiologie, Team Medisch, Circulatory Health, Regenerative Medicine and Stem Cells, Gezonde Vaten, CTC, Medische Staf Intensive Care, Medische Staf Spoedeisende Hulp, Medische staf Anesthesiologie, Other research (not in main researchprogram), Balder, Jan Willem, Szymanski, Mariusz K., van Laake, Linda W., van der Harst, Pim, Meuwese, Christiaan L., Ramjankhan, Faiz Z., van der Meer, Manon G., Hermens, Jeannine A.J.M., Voskuil, Michiel, de Waal, Eric E.C., Donker, Dirk W., Oerlemans, Marish I.F.J., and Kraaijeveld, Adriaan O.

Published
2024

19. Impairments identified by comprehensive geriatric assessment in potential candidates for left ventricular assist device and heart transplantation

Author

MS Geriatrie, Cardiologie, Team Medisch, Circulatory Health, Regenerative Medicine and Stem Cells, Unit Opleiding Geriatrie, CTC, Medische staf Anesthesiologie, Other research (not in main researchprogram), Dautzenberg, Lauren, van Laake, Linda W., Raijman, Renee C.M.A., Lefeber, Geert J., Knol, Wilma, Oerlemans, Marish I.F., Ramjankhan, Faiz Z., Braithwaite, Susan A., Nagtegaal, Mieke D.J., Emmelot-Vonk, Marielle H., Koek, Huiberdina L., MS Geriatrie, Cardiologie, Team Medisch, Circulatory Health, Regenerative Medicine and Stem Cells, Unit Opleiding Geriatrie, CTC, Medische staf Anesthesiologie, Other research (not in main researchprogram), Dautzenberg, Lauren, van Laake, Linda W., Raijman, Renee C.M.A., Lefeber, Geert J., Knol, Wilma, Oerlemans, Marish I.F., Ramjankhan, Faiz Z., Braithwaite, Susan A., Nagtegaal, Mieke D.J., Emmelot-Vonk, Marielle H., and Koek, Huiberdina L.

Published
2024

20. Transition From Temporary to Durable Circulatory Support Systems

Author

Saeed, Diyar, Potapov, Evgenij, Loforte, Antonio, Morshuis, Michiel, Schibilsky, David, Zimpfer, Daniel, Riebandt, Julia, Pappalardo, Federico, Attisani, Matteo, Rinaldi, Mauro, Haneya, Assad, Ramjankhan, Faiz, Donker, Dirk W., Jorde, Ulrich P., Stein, Julia, Tsyganenko, Dmytro, Jawad, Khalil, Wieloch, Radi, Ayala, Rafael, Cremer, Jochen, Borger, Michael A., Lichtenberg, Artur, and Gummert, Jan

Published
2020
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21. The European Registry for Patients with Mechanical Circulatory Support (EUROMACS): fourth Paediatric EUROMACS (Paedi-EUROMACS) report.

Author

Rohde, Sofie, Puyvelde, Joeri van, Veen, Kevin M, Schweiger, Martin, Biermann, Daniel, Amodeo, Antonio, Martens, Thomas, Damman, Kevin, Gollmann-Tepeköylü, Can, Hulman, Michael, Iacovoni, Attilio, Krämer, Ulrike S, Loforte, Antonio, Napoleone, Carlo Pace, Nemec, Petr, Netuka, Ivan, Özbaran, Mustafa, Polo, Luz, Pya, Yuriy, and Ramjankhan, Faiz

Subjects
ARTIFICIAL blood circulation, PULSATILE flow, STROKE, PROPORTIONAL hazards models, CONGENITAL heart disease
Abstract

OBJECTIVES The use of ventricular assist devices (VADs) in children is increasing. However, absolute numbers in individual centres and countries remain small. Collaborative efforts such as the Paedi-European Registry for Patients with Mechanical Circulatory Support (EUROMACS) are therefore essential for combining international experience with paediatric VADs. Our goal was to present the results from the fourth Paedi-EUROMACS report. METHODS All paediatric (<19 years) patients from the EUROMACS database supported by a VAD were included. Patients were stratified into a congenital heart disease (CHD) group and a group with a non-congenital aetiology. End points included mortality, a transplant and recovery. Cox proportional hazard models were used to explore associated factors for mortality, cerebrovascular accident and pump thrombosis. RESULTS A total of 590 primary implants were included. The congenital group was significantly younger (2.5 vs 8.0 years, respectively, P  < 0.001) and was more commonly supported by a pulsatile flow device (73.5% vs 59.9%, P  < 0.001). Mortality was significantly higher in the congenital group (30.8% vs 20.4%, P  = 0.009) than in the non-congenital group. However, in multivariable analyses, CHD was not significantly associated with mortality [hazard ratio (HR) 1.285; confidence interval (CI) 0.8111–2.036, P  = 0.740]. Pump thrombosis was the most frequently reported adverse event (377 events in 132 patients; 0.925 events per patient-year) and was significantly associated with body surface area (HR 0.524, CI 0.333–0.823, P  = 0.005), CHD (HR 1.641, CI 1.054–2.555, P  = 0.028) and pulsatile flow support (HR 2.345, CI 1.406–3.910, P  = 0.001) in multivariable analyses. CONCLUSIONS This fourth Paedi-EUROMACS report highlights the increasing use of paediatric VADs. The patient populations with congenital and non-congenital aetiologies exhibit distinct characteristics and clinical outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Soluble Suppression of Tumorigenicity‐2 Predicts Mortality and Right Heart Failure in Patients With a Left Ventricular Assist Device

Author

Numan, Lieke, primary, Aarts, Emmeke, additional, Ramjankhan, Faiz, additional, Oerlemans, Marish I. F., additional, van der Meer, Manon G., additional, de Jonge, Nicolaas, additional, Oppelaar, Anne‐Marie, additional, Kemperman, Hans, additional, Asselbergs, Folkert W., additional, and Van Laake, Linda W., additional

Published
2024
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23. Outcome of patients supported with the HeartMate 3 after extracorporeal life support

Author

Saeed, Diyar, primary, Stark, Christoffer, additional, Otto, Wolfgang, additional, Loforte, Antonio, additional, Zimpfer, Daniel, additional, Bernhardt, Alexander M., additional, Potapov, Evgenij, additional, Morshius, Michiel, additional, Schibilsky, David, additional, Albert, Alexander, additional, Raweh, Ayman, additional, Riebandt, Julia, additional, Pappalardo, Federico, additional, Attisani, Matteo, additional, Rinaldi, Mauro, additional, Haneya, Assad, additional, Huenges, Katharina, additional, Ramjankhan, Faiz, additional, Jorde, Ulrich P., additional, Lewin, Daniel, additional, Jawad, Khalil, additional, Aubin, Hug, additional, Ayala, Rafael, additional, Reichenspurner, Hermann, additional, Lichtenberg, Artur, additional, Borger, Michael, additional, and Gummert, Jan, additional

Published
2023
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24. Survival after HeartMate 3 left ventricular assist device implantation: real‐world data from Europe

Author

Numan, Lieke, primary, Schramm, Rene, additional, Oerlemans, Marish I.F.J., additional, van der Kaaij, Niels P., additional, Aarts, Emmeke, additional, Ramjankhan, Faiz Z., additional, Oppelaar, Anne‐Marie, additional, Morshuis, Michiel, additional, Guenther, Sabina P.W., additional, Zimpfer, Daniel, additional, Riebandt, Julia, additional, Wiedemann, Dominik, additional, Asselbergs, Folkert W., additional, and Van Laake, Linda W., additional

Published
2023
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26. Survival after HeartMate 3 left ventricular assist device implantation: real-world data from Europe

Author

Numan, Lieke, Schramm, Rene, Oerlemans, Marish I F J, van der Kaaij, Niels P, Aarts, Emmeke, Ramjankhan, Faiz Z, Oppelaar, Anne-Marie, Morshuis, Michiel, Guenther, Sabina P W, Zimpfer, Daniel, Riebandt, Julia, Wiedemann, Dominik, Asselbergs, Folkert W, Van Laake, Linda W, Numan, Lieke, Schramm, Rene, Oerlemans, Marish I F J, van der Kaaij, Niels P, Aarts, Emmeke, Ramjankhan, Faiz Z, Oppelaar, Anne-Marie, Morshuis, Michiel, Guenther, Sabina P W, Zimpfer, Daniel, Riebandt, Julia, Wiedemann, Dominik, Asselbergs, Folkert W, and Van Laake, Linda W

Published
2023

27. Incidence and risk factors of late right heart failure in chronic mechanical circulatory support

Author

Felix, Susanne E A, Numan, Lieke, Oerlemans, Marish I F, Aarts, E, Ramjankhan, Faiz Z, Gianoli, Monica, Asselbergs, Folkert W, De Jonge, Nicolaas, Van Laake, Linda W, Felix, Susanne E A, Numan, Lieke, Oerlemans, Marish I F, Aarts, E, Ramjankhan, Faiz Z, Gianoli, Monica, Asselbergs, Folkert W, De Jonge, Nicolaas, and Van Laake, Linda W

Abstract

Background: Late right heart failure (LRHF) is a common complication during long-term left ventricular assist device (LVAD) support. We aimed to identify risk factors for LRHF after LVAD implantation. Methods: Patients undergoing primary LVAD implantation between 2006 and 2019 and surviving the perioperative period were included for this study (n = 261). Univariate Cox proportional hazards analysis was used to assess the association of clinical covariates and LRHF, stratified for device type. Variables with p < 0.10 entered the multivariable model. In a subset of patients with complete echocardiography or right catheterization data, this multivariable model was extended. Postoperative cardiopulmonary exercise test data were compared in patients with and without LRHF. Results: Nineteen percentage of patients suffered from LRHF after a median of 12 months, of which 67% required hospitalization. A history of atrial fibrillation (AF) (HR: 2.06 [1.08–3.93], p = 0.029), a higher preoperative body mass index (BMI) (HR: 1.07 [1.01–1.13], p = 0.023), and intensive care unit (ICU) duration (HR: 1.03 [1.00–1.06], p = 0.025) were independent predictors of LHRF in the multivariable model. A significant relation between the severity of tricuspid regurgitation (TR) and LRHF (HR: 1.91 [1.13–3.21], p = 0.016) was found in patients with echocardiographic data. Patients with LRHF demonstrated a lower maximal workload and peak VO2 at 6 months postoperatively. Conclusion: A history of AF, BMI, and longer ICU stay may help identify patients at high risk for LRHF. Severity of TR was significantly related to LRHF in a subset of patients.

Published
2023

28. Identifying patients at risk: multi-centre comparison of HeartMate 3 and HeartWare left ventricular assist devices

Author

Numan, Lieke, Zimpfer, Daniel, Zadok, Osnat Itzhaki Ben, Aarts, Emmeke, Morshuis, Michiel, Guenther, Sabina P W, Riebandt, Julia, Wiedemann, Dominik, Ramjankhan, Faiz Z, Oppelaar, Anne-Marie, Ben-Gal, Tuvia, Ben-Avraham, Binyamin, Asselbergs, Folkert W, Schramm, Rene, Van Laake, Linda W, Numan, Lieke, Zimpfer, Daniel, Zadok, Osnat Itzhaki Ben, Aarts, Emmeke, Morshuis, Michiel, Guenther, Sabina P W, Riebandt, Julia, Wiedemann, Dominik, Ramjankhan, Faiz Z, Oppelaar, Anne-Marie, Ben-Gal, Tuvia, Ben-Avraham, Binyamin, Asselbergs, Folkert W, Schramm, Rene, and Van Laake, Linda W

Abstract

AIMS: Since the withdrawal of HeartWare (HVAD) from the global market, there is an ongoing discussion if and which patients require prophylactically exchange for a HeartMate 3 (HM3). Therefore, it is important to study outcome differences between HVAD and HM3 patients. Because centres differ in patient selection and standard of care, we performed a propensity score (PS)-based study including centres that implanted both devices and aimed to identify which HVAD patients are at highest risk.METHODS AND RESULTS: We performed an international multi-centre study (n = 1021) including centres that implanted HVAD and HM3. PS-matching was performed using clinical variables and the implanting centre. Survival and complications were compared. As a sensitivity analysis, PS-adjusted Cox regression was performed. Landmark analysis with conditional survival >2 years was conducted to evaluate long-term survival differences. To identify which HVAD patients may benefit from a HM3 upgrade, Cox regression using pre-operative variables and their interaction with device type was performed. Survival was significantly better for HM3 patients (P < 0.01) in 458 matched patients, with a median follow-up of 23 months. Within the matched cohort, HM3 patients had a median age of 58 years, and 83% were male, 80% of the HVAD patients were male, with a median age of 59 years. PS-adjusted Cox regression confirmed a significantly better survival for HM3 patients when compared with HVAD, with a HR of 1.46 (95% confidence interval 1.14-1.85, P < 0.01). Pump thrombosis (P < 0.01) and ischaemic stroke (P < 0.01) occurred less in HM3 patients. No difference was found for haemorrhagic stroke, right heart failure, driveline infection, and major bleeding. Landmark-analysis confirmed a significant difference in conditional survival >2 years after implantation (P = 0.03). None of the pre-operative variable interactions in the Cox regression were significant.CONCLUSIONS: HM3 pa

Published
2023

29. Survival after HeartMate 3 left ventricular assist device implantation: real-world data from Europe

Author

Leerstoel Klugkist, Methodology and statistics for the behavioural and social sciences, Numan, Lieke, Schramm, Rene, Oerlemans, Marish I F J, van der Kaaij, Niels P, Aarts, Emmeke, Ramjankhan, Faiz Z, Oppelaar, Anne-Marie, Morshuis, Michiel, Guenther, Sabina P W, Zimpfer, Daniel, Riebandt, Julia, Wiedemann, Dominik, Asselbergs, Folkert W, Van Laake, Linda W, Leerstoel Klugkist, Methodology and statistics for the behavioural and social sciences, Numan, Lieke, Schramm, Rene, Oerlemans, Marish I F J, van der Kaaij, Niels P, Aarts, Emmeke, Ramjankhan, Faiz Z, Oppelaar, Anne-Marie, Morshuis, Michiel, Guenther, Sabina P W, Zimpfer, Daniel, Riebandt, Julia, Wiedemann, Dominik, Asselbergs, Folkert W, and Van Laake, Linda W

Published
2023

30. Incidence and risk factors of late right heart failure in chronic mechanical circulatory support

Author

Leerstoel Klugkist, Methodology and statistics for the behavioural and social sciences, Felix, Susanne E A, Numan, Lieke, Oerlemans, Marish I F, Aarts, E, Ramjankhan, Faiz Z, Gianoli, Monica, Asselbergs, Folkert W, De Jonge, Nicolaas, Van Laake, Linda W, Leerstoel Klugkist, Methodology and statistics for the behavioural and social sciences, Felix, Susanne E A, Numan, Lieke, Oerlemans, Marish I F, Aarts, E, Ramjankhan, Faiz Z, Gianoli, Monica, Asselbergs, Folkert W, De Jonge, Nicolaas, and Van Laake, Linda W

Published
2023

31. Identifying patients at risk: multi-centre comparison of HeartMate 3 and HeartWare left ventricular assist devices

Author

Leerstoel Klugkist, Methodology and statistics for the behavioural and social sciences, Numan, Lieke, Zimpfer, Daniel, Zadok, Osnat Itzhaki Ben, Aarts, Emmeke, Morshuis, Michiel, Guenther, Sabina P W, Riebandt, Julia, Wiedemann, Dominik, Ramjankhan, Faiz Z, Oppelaar, Anne-Marie, Ben-Gal, Tuvia, Ben-Avraham, Binyamin, Asselbergs, Folkert W, Schramm, Rene, Van Laake, Linda W, Leerstoel Klugkist, Methodology and statistics for the behavioural and social sciences, Numan, Lieke, Zimpfer, Daniel, Zadok, Osnat Itzhaki Ben, Aarts, Emmeke, Morshuis, Michiel, Guenther, Sabina P W, Riebandt, Julia, Wiedemann, Dominik, Ramjankhan, Faiz Z, Oppelaar, Anne-Marie, Ben-Gal, Tuvia, Ben-Avraham, Binyamin, Asselbergs, Folkert W, Schramm, Rene, and Van Laake, Linda W

Published
2023

32. Identifying patients at risk: multi-centre comparison of HeartMate 3 and HeartWare left ventricular assist devices

Author

Onderzoek Precision medicine, CTC, Circulatory Health, Team Medisch, Regenerative Medicine and Stem Cells, Numan, Lieke, Zimpfer, Daniel, Zadok, Osnat Itzhaki Ben, Aarts, Emmeke, Morshuis, Michiel, Guenther, Sabina P W, Riebandt, Julia, Wiedemann, Dominik, Ramjankhan, Faiz Z, Oppelaar, Anne-Marie, Ben-Gal, Tuvia, Ben-Avraham, Binyamin, Asselbergs, Folkert W, Schramm, Rene, Van Laake, Linda W, Onderzoek Precision medicine, CTC, Circulatory Health, Team Medisch, Regenerative Medicine and Stem Cells, Numan, Lieke, Zimpfer, Daniel, Zadok, Osnat Itzhaki Ben, Aarts, Emmeke, Morshuis, Michiel, Guenther, Sabina P W, Riebandt, Julia, Wiedemann, Dominik, Ramjankhan, Faiz Z, Oppelaar, Anne-Marie, Ben-Gal, Tuvia, Ben-Avraham, Binyamin, Asselbergs, Folkert W, Schramm, Rene, and Van Laake, Linda W

Published
2023

33. Survival after HeartMate 3 left ventricular assist device implantation: real-world data from Europe

Author

Onderzoek Precision medicine, Team Medisch, Circulatory Health, CTC, MCS-team, Regenerative Medicine and Stem Cells, Numan, Lieke, Schramm, Rene, Oerlemans, Marish I F J, van der Kaaij, Niels P, Aarts, Emmeke, Ramjankhan, Faiz Z, Oppelaar, Anne-Marie, Morshuis, Michiel, Guenther, Sabina P W, Zimpfer, Daniel, Riebandt, Julia, Wiedemann, Dominik, Asselbergs, Folkert W, Van Laake, Linda W, Onderzoek Precision medicine, Team Medisch, Circulatory Health, CTC, MCS-team, Regenerative Medicine and Stem Cells, Numan, Lieke, Schramm, Rene, Oerlemans, Marish I F J, van der Kaaij, Niels P, Aarts, Emmeke, Ramjankhan, Faiz Z, Oppelaar, Anne-Marie, Morshuis, Michiel, Guenther, Sabina P W, Zimpfer, Daniel, Riebandt, Julia, Wiedemann, Dominik, Asselbergs, Folkert W, and Van Laake, Linda W

Published
2023

34. Insights in the Prothrombotic Changes after Implantation of a Left Ventricular Assist Device in Patients with End-Stage Heart Failure: A Longitudinal Observational Study

Author

Onderzoek CTC, Afdeling van Creveldkliniek - Zorg, Poli Van Creveldkliniek Medisch, Circulatory Health, CDL Chemie en POC, CDL Nanomedicine, CTC, CDL Research analisten, CDL Cluster 24/7 centraal laboratorium, Other research (not in main researchprogram), Cardiovasculaire Immunologie, Team Medisch, Pathologie Pathologen staf, Child Health, CDL Cluster Onderzoek en Onderwijs, Regenerative Medicine and Stem Cells, Infection & Immunity, Liesdek, Omayra C.D., Urbanus, Rolf T., De Maat, Steven, De Heer, Linda M., Ramjankhan, Faiz Z., Sebastian, Silvie A.E., Huisman, Albert, De Jonge, Nicolaas, Vink, Aryan, Fischer, Kathelijn, Maas, Coen, Suyker, Willem J.L., Schutgens, Roger E.G., Onderzoek CTC, Afdeling van Creveldkliniek - Zorg, Poli Van Creveldkliniek Medisch, Circulatory Health, CDL Chemie en POC, CDL Nanomedicine, CTC, CDL Research analisten, CDL Cluster 24/7 centraal laboratorium, Other research (not in main researchprogram), Cardiovasculaire Immunologie, Team Medisch, Pathologie Pathologen staf, Child Health, CDL Cluster Onderzoek en Onderwijs, Regenerative Medicine and Stem Cells, Infection & Immunity, Liesdek, Omayra C.D., Urbanus, Rolf T., De Maat, Steven, De Heer, Linda M., Ramjankhan, Faiz Z., Sebastian, Silvie A.E., Huisman, Albert, De Jonge, Nicolaas, Vink, Aryan, Fischer, Kathelijn, Maas, Coen, Suyker, Willem J.L., and Schutgens, Roger E.G.

Published
2023

35. Acquired blood platelet disorder in patients with end-stage heart failure after implantation of a continuous centrifugal-flow left ventricular assist device: A prospective cohort study

Author

Onderzoek CTC, Poli Van Creveldkliniek Medisch, Child Health, Circulatory Health, Infection & Immunity, CTC, CDL Patiëntenzorg KC, CDL Research analisten, MS Neonatologie, Regenerative Medicine and Stem Cells, Liesdek, Omayra C.D., Schutgens, Roger E.G., de Heer, Linda M., Ramjankhan, Faiz Z., Sebastian, Silvie A.E., Rohof, Joline J., Suyker, Willem J.L., Urbanus, Rolf T., Onderzoek CTC, Poli Van Creveldkliniek Medisch, Child Health, Circulatory Health, Infection & Immunity, CTC, CDL Patiëntenzorg KC, CDL Research analisten, MS Neonatologie, Regenerative Medicine and Stem Cells, Liesdek, Omayra C.D., Schutgens, Roger E.G., de Heer, Linda M., Ramjankhan, Faiz Z., Sebastian, Silvie A.E., Rohof, Joline J., Suyker, Willem J.L., and Urbanus, Rolf T.

Published
2023

36. Incidence and risk factors of late right heart failure in chronic mechanical circulatory support

Author

Aios en Stafsecr. Cardiologie, Onderzoek Precision medicine, Team Medisch, Circulatory Health, CTC, Regenerative Medicine and Stem Cells, Felix, Susanne E A, Numan, Lieke, Oerlemans, Marish I F, Aarts, E, Ramjankhan, Faiz Z, Gianoli, Monica, Asselbergs, Folkert W, de Jonge, Nicolaas, van Laake, Linda W, Aios en Stafsecr. Cardiologie, Onderzoek Precision medicine, Team Medisch, Circulatory Health, CTC, Regenerative Medicine and Stem Cells, Felix, Susanne E A, Numan, Lieke, Oerlemans, Marish I F, Aarts, E, Ramjankhan, Faiz Z, Gianoli, Monica, Asselbergs, Folkert W, de Jonge, Nicolaas, and van Laake, Linda W

Published
2023

37. Clinical outcome of transcatheter aortic valve replacement with TriGUARD 3™ cerebral embolic protection device

Author

Onderzoek CTC, Circulatory Health, Team Medisch, CTC, Daal, Sayonara M, Jimenez-Rodriguez, Gian M J, Voskuil, Michiel, Kraaijeveld, Adriaan O, Dessing, Thomas C, Ramjankhan, Faiz Z, Mokhles, Mostafa M, Stella, Pieter R, Onderzoek CTC, Circulatory Health, Team Medisch, CTC, Daal, Sayonara M, Jimenez-Rodriguez, Gian M J, Voskuil, Michiel, Kraaijeveld, Adriaan O, Dessing, Thomas C, Ramjankhan, Faiz Z, Mokhles, Mostafa M, and Stella, Pieter R

Published
2023

39. Identifying patients at risk: multi‐centre comparison of HeartMate 3 and HeartWare left ventricular assist devices

Author

Numan, Lieke, primary, Zimpfer, Daniel, additional, Zadok, Osnat Itzhaki Ben, additional, Aarts, Emmeke, additional, Morshuis, Michiel, additional, Guenther, Sabina P.W., additional, Riebandt, Julia, additional, Wiedemann, Dominik, additional, Ramjankhan, Faiz Z., additional, Oppelaar, Anne‐Marie, additional, Ben‐Gal, Tuvia, additional, Ben‐Avraham, Binyamin, additional, Asselbergs, Folkert W., additional, Schramm, Rene, additional, and Van Laake, Linda W., additional

Published
2023
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41. Platelet activation with the Aeson Bioprosthetic Total Artificial Heart: insight from aspirin treatment and outcomes

Author

Smadja, David M., primary, Peronino, Christophe, additional, Jilet, Léa, additional, Ivak, Peter, additional, Pya, Yuri, additional, Philippe, Aurélien, additional, Latremouille, Christian, additional, Gustafsson, Finn, additional, Ramjankhan, Faiz Z., additional, Roussel, Jean Christian, additional, Vincentelli, André, additional, Flecher, Erwan, additional, Gaussem, Pascale, additional, Jansen, Piet, additional, and Netuka, Ivan, additional

Published
2023
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45. Insights in the Prothrombotic Changes After Implantation of a Left Ventricular Assist Device in Patients With End-Stage Heart Failure: A Longitudinal Observational Study

Author

Liesdek, Omayra C.D., primary, Urbanus, Rolf T., additional, de Maat, Steven, additional, de Heer, Linda M., additional, Ramjankhan, Faiz Z., additional, Sebastian, Silvie A.E., additional, Huisman, Albert, additional, de Jonge, Nicolaas, additional, Vink, Aryan, additional, Fischer, Kathelijn, additional, Maas, Coen, additional, Suyker, Willem J.L., additional, and Schutgens, Roger E.G., additional

Published
2022
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47. Propensity score-based analysis of long-term outcome of patients on HeartWare and HeartMate 3 left ventricular assist device support

Author

Numan, Lieke, Ramjankhan, Faiz Z, Oberski, Daniel L, Oerlemans, Martinus I F J, Aarts, Emmeke, Gianoli, Monica, Van Der Heijden, Joris J, De Jonge, Nicolaas, Van Der Kaaij, Niels P, Meuwese, Christiaan L, Mokhles, Mostafa M, Oppelaar, Anne-Marie, De Waal, Eric E C, Asselbergs, Folkert W, Van Laake, Linda W, Leerstoel Klugkist, Methodology and statistics for the behavioural and social sciences, Leerstoel Klugkist, Methodology and statistics for the behavioural and social sciences, and Cardiology

Subjects
lcsh:Diseases of the circulatory (Cardiovascular) system, medicine.medical_specialty, LVAD, Centrifugal continuous flow pump, medicine.medical_treatment, Left ventricular assist device, law.invention, Brain Ischemia, Randomized controlled trial, law, Mechanical circulatory support, Internal medicine, Original Research Articles, medicine, Humans, Original Research Article, Propensity Score, Retrospective Studies, Proportional hazards model, business.industry, Hazard ratio, medicine.disease, Confidence interval, MCS, Stroke, lcsh:RC666-701, Ventricular assist device, Heart failure, Propensity score matching, Cardiology, Heart-Assist Devices, business, Cardiology and Cardiovascular Medicine, Destination therapy
Abstract

Aims Left ventricular assist device therapy has become the cornerstone in the treatment of end‐stage heart failure and is increasingly used as destination therapy next to bridge to transplant or recovery. HeartMate 3 (HM3) and HeartWare (HVAD) are centrifugal continuous flow devices implanted intrapericardially and most commonly used worldwide. No randomized controlled trials have been performed yet. Analysis based on large registries may be considered as the best alternative but has the disadvantage of different standard of care between centres and missing data. Bias is introduced, because the decision which device to use was not random, even more so because many centres use only one type of left ventricular assist device. Therefore, we performed a propensity score (PS)‐based analysis of long‐term clinical outcome of patients that received HM3 or HVAD in a single centre. Methods and results Between December 2010 and December 2019, 100 patients received HVAD and 81 patients HM3 as primary implantation at the University Medical Centre Utrecht. We performed PS matching with an extensive set of covariates, resulting in 112 matched patients with a median follow‐up of 28 months. After PS matching, survival was not significantly different (P = 0.21) but was better for HM3. The cumulative incidences for haemorrhagic stroke (P = 0.01) and pump thrombosis (P = 0.02) were significantly higher for HVAD patients. The cumulative incidences for major bleeding, ischaemic stroke, right heart failure, and driveline infection were not different between the groups. We found no interaction between the surgeon who performed the implantation and survival (P = 0.59, P = 0.78, and P = 0.89). Sensitivity analysis was performed, by PS matching without patients on preoperative temporary support resulting in 74 matched patients. This also resulted in a non‐significant difference in survival (P = 0.07). The PS‐adjusted Cox regression showed a worse but non‐significant (P = 0.10) survival for HVAD patients with hazard ratio 1.71 (95% confidence interval 0.91–3.24). Conclusions Survival was not significantly different between both groups after PS matching, but was better for HM3, with a significantly lower incidence of haemorrhagic stroke and pump thrombosis for HM3. These results need to be interpreted carefully, because matching may have introduced greater imbalance on unmeasured covariates. A multicentre approach of carefully selected centres is recommended to enlarge the number of matched patients.

Published
2021
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50. The European Registry for Patients with Mechanical Circulatory Support (EUROMACS): third Paediatric (Paedi-EUROMACS) report

Author

de By, Theo M M H, primary, Schweiger, Martin, additional, Hussain, Hina, additional, Amodeo, Antonio, additional, Martens, Thomas, additional, Bogers, Ad J J C, additional, Damman, Kevin, additional, Gollmnan-Tepeköylü, Can, additional, Hulman, Michael, additional, Iacovoni, Attilio, additional, Krämer, Ulrike, additional, Loforte, Antonio, additional, Napoleone, Carlo Pace, additional, Němec, Petr, additional, Netuka, Ivan, additional, Özbaran, Mustafa, additional, Polo, Luz, additional, Pya, Yuri, additional, Ramjankhan, Faiz, additional, Sandica, Eugen, additional, Sliwka, Joanna, additional, Stiller, Brigitte, additional, Kadner, Alexander, additional, Franceschini, Alessio, additional, Thiruchelvam, Timothy, additional, Zimpfer, Daniel, additional, Meyns, Bart, additional, Berger, Felix, additional, and Miera, Oliver, additional

Published
2022
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