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Reliability and SRD are important prerequisites for the correct interpreta- tion of spirometric data, which indicate to the clinician whether or not a genuine and real change has occurred. [...]the aim of this study has been to check the reliability of spirometric tests during the menstrual cycle phases and to investi- gate if spirometric variables are modified across the menstrual cycle. On the basis of the percentage of smallest real difference observed in the present study, the size of the relative change (SRD%) should exceed 6.5 % for FEV1, FVC and PEF and 8.3 % for MVV, to indicate a real change for a single individual. [...]these measurements could be used to detect real changes for a single individual following an intervention program, re- gardless of the menstrual cycle phase.