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2. BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors

Author

Sevdali, Eirini, primary, Block, Violeta, additional, Lataretu, Marie, additional, Li, Huiying, additional, Smulski, Cristian R., additional, Briem, Jana-Susann, additional, Heitz, Yannic, additional, Fischer, Beate, additional, Ramirez, Neftali-Jose, additional, Grimbacher, Bodo, additional, Jäck, Hans-Martin, additional, Voll, Reinhard E., additional, Hölzer, Martin, additional, Schneider, Pascal, additional, and Eibel, Hermann, additional

Published
2022
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3. BAFFR Activates PI3K/AKT Signaling in Human Naive But Not in Switched Memory B Cells Through Direct Interactions with B Cell Antigen Receptors

Author

Sevdali, Eirini, primary, Block, Violeta, additional, Lataretu, Marie, additional, Li, Huiying, additional, Smulski, Cristian R., additional, Briem, Jana-Susann, additional, Heitz, Yannic, additional, Fischer, Beate, additional, Ramirez, Neftali-Jose, additional, Grimbacher, Bodo, additional, Jäck, Hans-Martin, additional, Voll, Reinhard, additional, Hölzer, Martin, additional, Schneider, Pascal, additional, and Eibel, Hermann, additional

Published
2021
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6. Resident macrophages acquire innate immune memory in staphylococcal skin infection

Author

Feuerstein, Reinhild, Forde, Aaron James, Lohrmann, Florens, Kolter, Julia, Ramirez, Neftali Jose, Zimmermann, Jakob, Gomez De Agüero, Mercedes, and Henneke, Philipp

Subjects
integumentary system, 3. Good health
Abstract

Staphylococcus aureus (S. aureus) is a common colonizer of healthy skin and mucous membranes. At the same time, S. aureus is the most frequent cause of skin and soft tissue infections. Dermal macrophages (Mj) are critical for the coordinated defense against invading S. aureus, yet they have a limited life span with replacement by bone marrow derived monocytes. It is currently poorly understood whether localized S. aureus skin infections persistently alter the resident Mj subset composition and resistance to a subsequent infection. In a strictly dermal infection model we found that mice, which were previously infected with S. aureus, showed faster monocyte recruitment, increased bacterial killing and improved healing upon a secondary infection. However, skin infection decreased Mj half-life, thereby limiting the duration of memory. In summary, resident dermal Mj are programmed locally, independently of bone marrow-derived monocytes during staphylococcal skin infection leading to transiently increased resistance against a second infection.

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